EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26212606	TRAIL-Induced Caspase Activation Is a Prerequisite for Activation of the Endoplasmic Reticulum Stress-Induced Signal Transduction Pathways.	J Cell Biochem	2016 May	Lee DH	doi: 10.1002/jcb.25289
24395279	Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients.	Int J Cancer	2014 Jun 1	Fleischer T	doi: 10.1002/ijc.28606
29653744	Low expression of B-Cell-Associated protein 31 is associated with unfavorable prognosis in human colorectal cancer.	Pathol Res Pract	2018 May	Ma C	doi: 10.1016/j.prp.2018.03.023

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chrX	153700756	3'UTR	novel		0.06
BLCA	chrX	153702932	Splice_Region	novel		0.3
BLCA	chrX	153715576	Missense_Mutation	novel	L103V	0.65
BRCA	chrX	153702077	Missense_Mutation	NA	A211V	0.4
BRCA	chrX	153704083	Missense_Mutation	rs782366321	R118H	0.46
BRCA	chrX	153720902	Missense_Mutation	NA	L55F	0.23
BRCA	chrX	153720873	Splice_Region	rs782139553	I64I	0.34
BRCA	chrX	153704065	Missense_Mutation	novel	S124L	0.08
BRCA	chrX	153702059	Missense_Mutation	novel	E217V	0.27
CESC	chrX	153702060	Missense_Mutation	novel	E217K	0.2
CESC	chrX	153702039	Missense_Mutation	rs782016039	D224N	0.12
CESC	chrX	153715652	Silent	NA	T77T	0.4
CESC	chrX	153723557	Intron	novel		0.4
CESC	chrX	153723682	Intron	novel		0.33
CESC	chrX	153715663	Missense_Mutation	NA	D74N	0.69
COAD	chrX	153723535	Intron	NA		0.36
COAD	chrX	153715652	Silent	NA	T77T	0.2
COAD	chrX	153720986	Intron	novel		0.2
COAD	chrX	153704064	Silent	rs782427826	S124S	0.34
COAD	chrX	153723536	Intron	NA		0.18
ESCA	chrX	153702036	Missense_Mutation	novel	R225C	0.34
HNSC	chrX	153715626	Missense_Mutation	novel	P86L	0.38
HNSC	chrX	153702957	Silent	rs141341467	D193D	0.29
HNSC	chrX	153702075	Missense_Mutation	novel	M212L	0.24
HNSC	chrX	153723167	Silent	novel	F26F	0.25
KIRP	chrX	153723203	Silent	rs782120731	A14A	0.44
LGG	chrX	153700887	3'UTR	novel		0.43
LIHC	chrX	153700963	Missense_Mutation	novel	G239S	0.34
LUAD	chrX	153715616	Missense_Mutation	NA	M89I	0.3
LUAD	chrX	153702031	Missense_Mutation	NA	L226F	0.23
LUAD	chrX	153703004	Frame_Shift_Del	novel	*E178Rfs7**	0.23
LUAD	chrX	153715679	Silent	rs781786906	R68R	0.14
LUSC	chrX	153715562	Silent	novel	G107G	0.86
LUSC	chrX	153703055	Missense_Mutation	novel	A161P	0.27
LUSC	chrX	153700876	3'UTR	novel		0.22
LUSC	chrX	153715624	Missense_Mutation	novel	G87W	0.75
LUSC	chrX	153715625	Silent	rs782421344	P86P	0.92
LUSC	chrX	153703998	Silent	novel	A146A	0.16
OV	chrX	153704026	Missense_Mutation	novel	K137T	0.07
OV	chrX	153704045	Missense_Mutation	novel	A131T	0.06
OV	chrX	153715678	Missense_Mutation	NA	E69K	0.27
READ	chrX	153715647	Missense_Mutation	novel	K79T	0.24
SARC	chrX	153715549	Silent	novel	L112L	0.31
SKCM	chrX	153715591	Missense_Mutation	NA	R98C	0.81
SKCM	chrX	153715592	Silent	novel	F97F	0.85
SKCM	chrX	153715652	Silent	NA	T77T	0.72
SKCM	chrX	153715678	Missense_Mutation	NA	E69K	0.33
SKCM	chrX	153715591	Missense_Mutation	NA	R98C	0.38
STAD	chrX	153723268	5'UTR	novel		0.32
STAD	chrX	153700810	3'UTR	novel		0.5
THCA	chrX	153720902	Missense_Mutation	NA	L55F	0.08
UCEC	chrX	153704061	Silent	NA	Q125Q	0.43
UCEC	chrX	153700971	Missense_Mutation	NA	A236E	0.31
UCEC	chrX	153723199	Missense_Mutation	NA	V16F	0.34
UCEC	chrX	153702979	Missense_Mutation	novel	A186V	0.14
UCEC	chrX	153704095	Splice_Site	novel	X114_splice	0.46
UCEC	chrX	153702058	Silent	novel	E217E	0.47
UCEC	chrX	153715563	Missense_Mutation	novel	G107D	0.41
UCEC	chrX	153723591	Intron	rs781974660		0.2
UCEC	chrX	153723651	Intron	novel		0.18
UCEC	chrX	153723699	Intron	novel		0.2
UCEC	chrX	153723756	Intron	novel		0.3
UCEC	chrX	153702107	Missense_Mutation	rs782083125	K201R	0.35
UCEC	chrX	153723274	5'UTR	novel		0.39
UCEC	chrX	153700946	Missense_Mutation	novel	K244N	0.61
UCEC	chrX	153700730	3'UTR	NA		0.38
UCEC	chrX	153702980	Missense_Mutation	novel	A186P	0.77
UCEC	chrX	153715653	Missense_Mutation	rs782018233	T77M	0.27
UCEC	chrX	153720891	Silent	rs782229978	I58I	0.19
UCEC	chrX	153702072	Missense_Mutation	rs372317882	R213W	0.34
UCEC	chrX	153704005	Missense_Mutation	novel	S144T	0.37
UCEC	chrX	153704031	Silent	novel	A135A	0.32
UCEC	chrX	153715572	Missense_Mutation	novel	Y104C	0.4
UCEC	chrX	153720963	Missense_Mutation	novel	K34N	0.32
UCEC	chrX	153703059	Splice_Site	novel	X160_splice	0.2
UCEC	chrX	153700743	3'UTR	novel		0.17
UCEC	chrX	153720912	Missense_Mutation	novel	F51L	0.28
UCEC	chrX	153723645	Intron	rs781848286		0.27
UCEC	chrX	153704013	Missense_Mutation	novel	E141D	0.29
UCEC	chrX	153723530	Intron	novel		0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1898	3.2002e-05
DLBC	AMP	0.1458	0.24013
ESCA	AMP	0.2717	0.18371
HNSC	AMP	0.2088	0.0095371
KIRC	AMP	0.0436	0.12739
LIHC	AMP	0.1486	0.011319
LUSC	AMP	0.1737	0.08275
OV	AMP	0.3092	2.176e-06
PAAD	AMP	0.0815	0.041079
READ	AMP	0.1515	0.14805
STAD	AMP	0.1134	0.0021069
TGCT	DEL	0.0667	0.08422
THCA	DEL	0.002	0.21991
UCS	DEL	0.2857	0.063955

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.021	Kaplan-Meier Survival Analysis
STAD	0.045	Kaplan-Meier Survival Analysis
HNSC	0.00045	Kaplan-Meier Survival Analysis
ESCA	0.00011	Kaplan-Meier Survival Analysis
READ	0.0075	Kaplan-Meier Survival Analysis
LAML	0.0002	Kaplan-Meier Survival Analysis
GBM	0.0036	Kaplan-Meier Survival Analysis
LIHC	0.0041	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.05	Kaplan-Meier Survival Analysis
UVM	0.032	Kaplan-Meier Survival Analysis
OV	0.044	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000185825 (Gene tree)
Gene ID: 10134
Gene Symbol: BCAP31
Alias: DXS1357E|BAP31|6C6-Ag|CDM
Full Name: B cell receptor associated protein 31
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 24,255 bases
Position: chrX:153,700,492-153,724,746
Accession: 16695
RBP type: non-canonical RBP
Summary: This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000416815	BCAP31-202	688	-	ENSP00000394270	182 (aa)	-	C9JSP1
ENST00000647529	BCAP31-213	1433	-	ENSP00000494052	246 (aa)	-	P51572
ENST00000645006	BCAP31-209	893	-	-	- (aa)	-	-
ENST00000468947	BCAP31-208	409	-	-	- (aa)	-	-
ENST00000458587	BCAP31-207	1824	-	ENSP00000392330	313 (aa)	-	P51572
ENST00000646514	BCAP31-212	1217	-	-	- (aa)	-	-
ENST00000645377	BCAP31-210	1175	-	ENSP00000494936	211 (aa)	-	A0A2R8Y5M6
ENST00000645802	BCAP31-211	573	-	-	- (aa)	-	-
ENST00000442093	BCAP31-206	793	-	ENSP00000400345	188 (aa)	-	C9J0M4
ENST00000430088	BCAP31-205	570	-	ENSP00000402342	138 (aa)	-	C9JM14
ENST00000423827	BCAP31-203	669	-	ENSP00000389740	178 (aa)	-	C9JMD7
ENST00000429550	BCAP31-204	684	-	ENSP00000409888	187 (aa)	-	C9JQ75
ENST00000345046	BCAP31-201	1643	-	ENSP00000343458	246 (aa)	-	P51572

Gene Model

Click here to download ENSG00000185825's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa05165	Human papillomavirus infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000185825's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	-	TAS	Process
GO:0005515	protein binding	9334338.15024066.18555783.21183955.25854864.	IPI	Function
GO:0005739	mitochondrion	-	IEA	Component
GO:0005783	endoplasmic reticulum	18555783.19401338.21183955.24454821.	IDA	Component
GO:0005784	Sec61 translocon complex	18555783.	IPI	Component
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005811	lipid droplet	14741744.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005887	integral component of plasma membrane	21873635.	IBA	Component
GO:0005887	integral component of plasma membrane	8706661.	IDA	Component
GO:0006886	intracellular protein transport	-	IEA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0007204	positive regulation of cytosolic calcium ion concentration	21183955.	IMP	Process
GO:0007283	spermatogenesis	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0030136	clathrin-coated vesicle	-	IEA	Component
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	21183955.	IMP	Process
GO:0032580	Golgi cisterna membrane	-	IEA	Component
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	-	IEA	Component
GO:0035584	calcium-mediated signaling using intracellular calcium source	21183955.	IMP	Process
GO:0042288	MHC class I protein binding	-	IEA	Function
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	21183955.	IMP	Process
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0051561	positive regulation of mitochondrial calcium ion concentration	21183955.	IMP	Process
GO:0070973	protein localization to endoplasmic reticulum exit site	21873635.	IBA	Process
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane	-	TAS	Component
GO:0097038	perinuclear endoplasmic reticulum	25854864.	IDA	Component
GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process	18555783.	IGI	Process
GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	18555783.	IDA	Process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	21183955.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.