EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27058786	Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.	Mol Cell	2016 Apr 7	Tan JL	doi: 10.1016/j.molcel.2016.03.013.
26608417	Role of tumor-associated macrophages in the Hexim1 and TGFβ/SMAD pathway, and their influence on progression of prostatic adenocarcinoma.	Pathol Res Pract	2016 Feb	Ok Atlgan A	doi: 10.1016/j.prp.2015.10.011
22948151	Identification of HEXIM1 as a positive regulator of p53.	J Biol Chem	2012 Oct 19	Lew QJ	doi: 10.1074/jbc.M112.374157
20453883	HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland.	Oncogene	2010 Jun 24	Ogba N	doi: 10.1038/onc.2010.110
22095517	Hexim-1 modulates androgen receptor and the TGF-β signaling during the progression of prostate cancer.	Prostate	2012 Jun 15	Mascareno EJ	doi: 10.1002/pros.21510

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr17	45149267	Missense_Mutation	novel	E26V	0.35
BLCA	chr17	45149413	Missense_Mutation	novel	Q75E	0.14
BLCA	chr17	45149993	Missense_Mutation	NA	S268L	0.37	HEXIM
BLCA	chr17	45149991	Silent	rs780372202	F267F	0.59
BLCA	chr17	45150372	3'UTR	novel		0.46
BLCA	chr17	45150100	Missense_Mutation	NA	E304K	0.1
BLCA	chr17	45149820	Missense_Mutation	novel	M210I	0.31	HEXIM
BLCA	chr17	45149893	Missense_Mutation	NA	D235Y	0.17	HEXIM
BLCA	chr17	45149499	Missense_Mutation	rs753721065	F103L	0.24
BLCA	chr17	45150006	Missense_Mutation	novel	E272D	0.19	HEXIM
BLCA	chr17	45149499	Silent	NA	F103F	0.38
BLCA	chr17	45150242	Missense_Mutation	rs756384069	R351Q	0.2
BLCA	chr17	45149744	Missense_Mutation	novel	R185Q	0.48	HEXIM
BRCA	chr17	45148504	5'UTR	novel		1
BRCA	chr17	45149667	Silent	NA	K159K	0.24
BRCA	chr17	45149077	5'UTR	novel		0.6
BRCA	chr17	45149899	Frame_Shift_Del	NA	*S237Mfs45**	0.41	HEXIM
CESC	chr17	45151812	3'UTR	novel		0.1
CESC	chr17	45149466	Missense_Mutation	NA	Q92H	0.48
CESC	chr17	45149174	5'UTR	novel		0.07
CESC	chr17	45149445	Silent	NA	L85L	0.4
CESC	chr17	45149466	Missense_Mutation	NA	Q92H	0.43
CESC	chr17	45149314	Missense_Mutation	NA	E42Q	0.41
CESC	chr17	45151223	3'UTR	novel		0.5
CESC	chr17	45152050	3'UTR	novel		0.25
CESC	chr17	45151652	3'UTR	novel		0.41
CHOL	chr17	45150627	3'UTR	novel		0.46
CHOL	chr17	45151387	3'UTR	novel		0.3
COAD	chr17	45151307	3'UTR	novel		0.32
COAD	chr17	45151015	3'UTR	novel		0.39
COAD	chr17	45150385	3'UTR	novel		0.28
COAD	chr17	45150771	3'UTR	novel		0.3
COAD	chr17	45150046	Missense_Mutation	novel	E286K	0.52	HEXIM
COAD	chr17	45151567	3'UTR	novel		0.27
COAD	chr17	45150849	3'UTR	novel		0.23
COAD	chr17	45151709	3'UTR	novel		0.2
COAD	chr17	45150156	In_Frame_Del	NA	R323_E324del	0.45
COAD	chr17	45151307	3'UTR	novel		0.44
COAD	chr17	45149785	Missense_Mutation	novel	P199S	0.5	HEXIM
COAD	chr17	45151307	3'UTR	novel		0.27
COAD	chr17	45151307	3'UTR	novel		0.32
COAD	chr17	45151967	3'UTR	novel		0.06
COAD	chr17	45151863	3'UTR	novel		0.29
COAD	chr17	45151000	3'UTR	novel		0.09
COAD	chr17	45151307	3'UTR	novel		0.56
COAD	chr17	45150344	3'UTR	novel		0.36
COAD	chr17	45150616	3'UTR	novel		0.38
COAD	chr17	45150716	3'UTR	novel		0.38
COAD	chr17	45151307	3'UTR	novel		0.21
ESCA	chr17	45150575	3'UTR	novel		0.1
ESCA	chr17	45150011	In_Frame_Ins	novel	H275_S283dup	0.26	HEXIM
ESCA	chr17	45151438	3'UTR	novel		0.35
ESCA	chr17	45150019	Missense_Mutation	novel	E277K	0.07	HEXIM
GBM	chr17	45149286	Frame_Shift_Del	novel	*P34Qfs52**	0.41
HNSC	chr17	45149095	5'UTR	novel		0.41
HNSC	chr17	45150279	3'UTR	novel		0.11
HNSC	chr17	45149373	Frame_Shift_Del	novel	*E62Gfs23**	0.17
HNSC	chr17	45149512	Missense_Mutation	novel	E108Q	0.44
HNSC	chr17	45149881	Missense_Mutation	NA	A231T	0.29	HEXIM
HNSC	chr17	45150067	Nonsense_Mutation	novel	E293*	0.38	HEXIM
KICH	chr17	45151307	3'UTR	novel		0.19
KIRC	chr17	45149316	Silent	NA	E42E	0.2
KIRC	chr17	45151996	3'UTR	novel		0.11
KIRC	chr17	45149161	5'UTR	novel		0.33
KIRP	chr17	45151563	3'UTR	novel		0.08
KIRP	chr17	45150586	3'UTR	novel		0.21
KIRP	chr17	45151310	3'UTR	novel		0.07
LAML	chr17	45149937	Frame_Shift_Ins	novel	*S252Qfs111**	0.1	HEXIM
LGG	chr17	45149930	Missense_Mutation	novel	E247G	0.13	HEXIM
LIHC	chr17	45150790	3'UTR	novel		0.39
LIHC	chr17	45151307	3'UTR	novel		0.24
LIHC	chr17	45149335	Missense_Mutation	novel	S49T	0.3
LIHC	chr17	45150361	3'UTR	novel		0.14
LIHC	chr17	45150333	3'UTR	novel		0.43
LIHC	chr17	45151200	3'UTR	novel		0.28
LIHC	chr17	45150313	3'UTR	novel		0.18
LUAD	chr17	45149314	Missense_Mutation	NA	E42Q	0.15
LUAD	chr17	45149602	Missense_Mutation	rs573692319	E138K	0.11
LUAD	chr17	45150166	Nonsense_Mutation	novel	E326*	0.08
LUAD	chr17	45150151	Missense_Mutation	novel	R321C	0.24
LUAD	chr17	45149710	Missense_Mutation	novel	E174K	0.09	HEXIM
LUAD	chr17	45149979	Silent	novel	L263L	0.12
LUAD	chr17	45150096	Silent	rs200141058	E302E	0.32
LUAD	chr17	45149314	Missense_Mutation	novel	E42K	0.09
LUSC	chr17	45149950	Missense_Mutation	novel	G254R	0.33	HEXIM
LUSC	chr17	45150043	Nonsense_Mutation	novel	Q285*	0.19	HEXIM
OV	chr17	45149239	Missense_Mutation	NA	N17Y	0.13
OV	chr17	45150158	In_Frame_Ins	novel	E328_L329dup	0.31
PAAD	chr17	45149203	Missense_Mutation	rs755261268	F5L	0.32
PAAD	chr17	45149900	Missense_Mutation	novel	S237I	0.15	HEXIM
PAAD	chr17	45150282	3'UTR	novel		0.2
READ	chr17	45150336	3'UTR	novel		0.07
READ	chr17	45151730	3'UTR	novel		0.12
SARC	chr17	45150497	3'UTR	novel		0.33
SKCM	chr17	45149326	Silent	NA	R46R	0.1
SKCM	chr17	45149224	Missense_Mutation	novel	Q12K	0.02
SKCM	chr17	45149823	Silent	novel	D211D	0.12
SKCM	chr17	45149421	Silent	NA	Q77Q	0.5
STAD	chr17	45150046	Missense_Mutation	NA	E286Q	0.21	HEXIM
STAD	chr17	45149632	Silent	novel	L148L	0.44
STAD	chr17	45150427	3'UTR	novel		0.27
STAD	chr17	45149131	5'UTR	novel		0.21
STAD	chr17	45150169	Silent	novel	L327L	0.18
STAD	chr17	45149095	5'UTR	novel		0.53
STAD	chr17	45149095	5'UTR	novel		0.36
STAD	chr17	45149095	5'UTR	novel		0.36
STAD	chr17	45149095	5'UTR	novel		0.42
STAD	chr17	45149893	Missense_Mutation	NA	D235N	0.33	HEXIM
STAD	chr17	45150030	Silent	rs761857124	Q280Q	0.4
STAD	chr17	45149766	Missense_Mutation	novel	E192D	0.23	HEXIM
STAD	chr17	45149693	Missense_Mutation	NA	Y168C	0.24	HEXIM
UCEC	chr17	45151923	3'UTR	novel		0.13
UCEC	chr17	45151367	3'UTR	novel		0.1
UCEC	chr17	45151612	3'UTR	novel		0.33
UCEC	chr17	45151307	3'UTR	novel		0.56
UCEC	chr17	45149970	Silent	novel	S260S	0.25
UCEC	chr17	45150839	3'UTR	novel		0.48
UCEC	chr17	45149820	Missense_Mutation	novel	M210I	0.26	HEXIM
UCEC	chr17	45150130	Missense_Mutation	novel	R314W	0.39
UCEC	chr17	45148683	5'UTR	novel		0.2
UCEC	chr17	45150982	3'UTR	novel		0.38
UCEC	chr17	45151547	3'UTR	novel		0.3
UCEC	chr17	45151119	3'UTR	novel		0.2
UCEC	chr17	45149084	5'UTR	novel		0.6
UCEC	chr17	45150071	Missense_Mutation	NA	L294P	0.44	HEXIM
UCEC	chr17	45151307	3'UTR	novel		0.46
UCEC	chr17	45151119	3'UTR	novel		0.32
UCEC	chr17	45151535	3'UTR	novel		0.19
UCEC	chr17	45150885	3'UTR	novel		0.13
UCEC	chr17	45151119	3'UTR	novel		0.33
UCEC	chr17	45151156	3'UTR	novel		0.27
UCEC	chr17	45151797	3'UTR	novel		0.29
UCEC	chr17	45151201	3'UTR	novel		0.27
UCEC	chr17	45152102	3'Flank	novel		0.44
UCEC	chr17	45150852	3'UTR	novel		0.15
UCEC	chr17	45149635	Missense_Mutation	novel	G149R	0.42
UCEC	chr17	45149605	Nonsense_Mutation	novel	E139*	0.64
UCEC	chr17	45151769	3'UTR	novel		0.38
UCEC	chr17	45149145	5'UTR	novel		0.33
UCEC	chr17	45150368	3'UTR	novel		0.22
UCEC	chr17	45149796	Silent	novel	P202P	0.41
UCEC	chr17	45150440	3'UTR	novel		0.27
UCEC	chr17	45149166	5'UTR	novel		0.46
UCEC	chr17	45150280	3'UTR	novel		0.48
UCEC	chr17	45151466	3'UTR	novel		0.4
UCEC	chr17	45149415	Missense_Mutation	rs756233346	Q75H	0.48
UCEC	chr17	45152056	3'UTR	novel		0.38
UCEC	chr17	45150869	3'UTR	novel		0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2954	4.8302e-10
DLBC	DEL	0.0208	0.18166
THCA	DEL	0.002	0.221
UCEC	DEL	0.1837	5.8317e-06
UCS	DEL	0.3571	0.19877
UVM	DEL	0.0375	0.22482

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0095	Kaplan-Meier Survival Analysis
ACC	0.041	Kaplan-Meier Survival Analysis
PAAD	0.05	Kaplan-Meier Survival Analysis
BLCA	0.021	Kaplan-Meier Survival Analysis
LAML	0.00017	Kaplan-Meier Survival Analysis
UCEC	0.047	Kaplan-Meier Survival Analysis
LIHC	0.047	Kaplan-Meier Survival Analysis
THCA	0.0056	Kaplan-Meier Survival Analysis
LUAD	0.043	Kaplan-Meier Survival Analysis
UVM	0.0004	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000186834 (Gene tree)
Gene ID: 10614
Gene Symbol: HEXIM1
Alias: CLP-1|HIS1|MAQ1|EDG1
Full Name: HEXIM P-TEFb complex subunit 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 4,785 bases
Position: chr17:45,147,317-45,152,101
Accession: 24953
RBP type: canonical RBP
Summary: Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000328773	HEXIM	PF15313.6	5.1e-60	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15965233	Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.	J Biol Chem	2005 Aug 5	Li Q	-
15169877	A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb.	Mol Cell Biol	2004 Jun	Yik JH	-
19244621	U30 of 7SK RNA forms a specific photo-cross-link with Hexim1 in the context of both a minimal RNA-binding site and a fully reconstituted 7SK/Hexim1/P-TEFb ribonucleoprotein complex.	J Mol Biol	2009 Mar 6	Belanger F	-
17395637	HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells.	Nucleic Acids Res	2007	Li Q	-
15994294	Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer.	J Biol Chem	2005 Aug 26	Dulac C	-
15201869	Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.	EMBO J	2004 Jul 7	Michels AA	-
22609015	HEXIM1-binding elements on mRNAs identified through transcriptomic SELEX and computational screening.	Biochimie	2012 Sep	Fujimoto Y	doi: 10.1016/j.biochi.2012.05.003
24917669	Genetic analysis of the structure and function of 7SK small nuclear ribonucleoprotein (snRNP) in cells.	J Biol Chem	2014 Jul 25	Fujinaga K	-
12832472	MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.	Mol Cell Biol	2003 Jul	Michels AA	-
27852926	Solution structure of the 5'-terminal hairpin of the 7SK small nuclear RNA.	RNA	2016 Dec	Bourbigot S	-
16382153	Regulation of polymerase II transcription by 7SK snRNA: two distinct RNA elements direct P-TEFb and HEXIM1 binding.	Mol Cell Biol	2006 Jan	Egloff S	-
19246988	7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor.	RNA Biol	2009 Apr-Jun	Diribarne G	-
17709395	The transcription-dependent dissociation of P-TEFb-HEXIM1-7SK RNA relies upon formation of hnRNP-7SK RNA complexes.	Mol Cell Biol	2007 Oct	Barrandon C	-
24985467	A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription.	Retrovirology	2014 Jul 1	Kuzmina A	doi: 10.1186/1742-4690-11-51.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000332499	HEXIM1-201	3600	-	ENSP00000328773	359 (aa)	-	O94992

Gene Model

Click here to download ENSG00000186834's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000186834's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000186834	HEXIM1	55	54.229	ENSG00000168517	HEXIM2	65	52.239

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000186834	HEXIM1	51	56.477	ENSAPOG00000005717	hexim1	58	58.852	Acanthochromis_polyacanthus
ENSG00000186834	HEXIM1	55	54.271	ENSAMEG00000018404	HEXIM2	60	52.736	Ailuropoda_melanoleuca
ENSG00000186834	HEXIM1	100	89.972	ENSAMEG00000019935	HEXIM1	100	89.972	Ailuropoda_melanoleuca
ENSG00000186834	HEXIM1	55	58.491	ENSACIG00000008752	hexim1	58	60.096	Amphilophus_citrinellus
ENSG00000186834	HEXIM1	51	55.959	ENSAOCG00000010682	hexim1	58	58.373	Amphiprion_ocellaris
ENSG00000186834	HEXIM1	51	55.959	ENSAPEG00000002466	hexim1	58	58.373	Amphiprion_percula
ENSG00000186834	HEXIM1	52	79.787	ENSAPLG00000007934	HEXIM1	100	79.787	Anas_platyrhynchos
ENSG00000186834	HEXIM1	67	75.102	ENSACAG00000016321	HEXIM1	77	75.102	Anolis_carolinensis
ENSG00000186834	HEXIM1	100	97.772	ENSANAG00000012950	HEXIM1	100	97.772	Aotus_nancymaae
ENSG00000186834	HEXIM1	51	50.811	ENSANAG00000034525	HEXIM2	65	51.000	Aotus_nancymaae
ENSG00000186834	HEXIM1	55	58.491	ENSACLG00000000640	hexim1	58	60.096	Astatotilapia_calliptera
ENSG00000186834	HEXIM1	55	53.465	ENSBTAG00000024974	HEXIM2	65	51.980	Bos_taurus
ENSG00000186834	HEXIM1	100	80.501	ENSBTAG00000006056	HEXIM1	100	80.501	Bos_taurus
ENSG00000186834	HEXIM1	100	96.379	ENSCJAG00000041689	HEXIM1	100	96.379	Callithrix_jacchus
ENSG00000186834	HEXIM1	51	51.075	ENSCJAG00000046816	-	89	44.141	Callithrix_jacchus
ENSG00000186834	HEXIM1	51	51.075	ENSCJAG00000047668	-	82	44.141	Callithrix_jacchus
ENSG00000186834	HEXIM1	55	51.244	ENSCJAG00000047902	-	65	49.254	Callithrix_jacchus
ENSG00000186834	HEXIM1	51	51.075	ENSCJAG00000048269	-	82	44.141	Callithrix_jacchus
ENSG00000186834	HEXIM1	99	89.831	ENSCAFG00000024148	HEXIM1	94	89.831	Canis_familiaris
ENSG00000186834	HEXIM1	55	54.680	ENSCAFG00000013831	HEXIM2	66	53.171	Canis_familiaris
ENSG00000186834	HEXIM1	55	54.680	ENSCAFG00020009518	HEXIM2	65	53.171	Canis_lupus_dingo
ENSG00000186834	HEXIM1	100	90.529	ENSCAFG00020009524	HEXIM1	100	90.529	Canis_lupus_dingo
ENSG00000186834	HEXIM1	100	81.058	ENSCHIG00000003683	HEXIM1	100	81.058	Capra_hircus
ENSG00000186834	HEXIM1	55	52.764	ENSCHIG00000006446	HEXIM2	65	51.256	Capra_hircus
ENSG00000186834	HEXIM1	55	48.756	ENSTSYG00000031348	HEXIM2	68	47.264	Carlito_syrichta
ENSG00000186834	HEXIM1	74	88.426	ENSTSYG00000031366	HEXIM1	100	87.124	Carlito_syrichta
ENSG00000186834	HEXIM1	60	83.945	ENSCPOG00000007132	-	96	83.945	Cavia_porcellus
ENSG00000186834	HEXIM1	51	51.075	ENSCCAG00000036207	HEXIM2	65	50.746	Cebus_capucinus
ENSG00000186834	HEXIM1	100	96.657	ENSCCAG00000019243	HEXIM1	100	96.657	Cebus_capucinus
ENSG00000186834	HEXIM1	100	97.772	ENSCATG00000014762	HEXIM1	100	97.772	Cercocebus_atys
ENSG00000186834	HEXIM1	55	54.229	ENSCATG00000034723	HEXIM2	66	52.239	Cercocebus_atys
ENSG00000186834	HEXIM1	100	97.772	ENSCSAG00000019019	HEXIM1	100	97.772	Chlorocebus_sabaeus
ENSG00000186834	HEXIM1	55	54.229	ENSCSAG00000003672	HEXIM2	65	52.239	Chlorocebus_sabaeus
ENSG00000186834	HEXIM1	66	83.750	ENSCPBG00000008858	HEXIM1	99	81.781	Chrysemys_picta_bellii
ENSG00000186834	HEXIM1	55	54.229	ENSCANG00000031165	HEXIM2	66	52.239	Colobus_angolensis_palliatus
ENSG00000186834	HEXIM1	100	97.772	ENSCANG00000019421	HEXIM1	100	97.772	Colobus_angolensis_palliatus
ENSG00000186834	HEXIM1	100	85.515	ENSCGRG00001002270	Hexim1	100	85.515	Cricetulus_griseus_chok1gshd
ENSG00000186834	HEXIM1	55	55.172	ENSCGRG00001014831	Hexim2	60	53.659	Cricetulus_griseus_chok1gshd
ENSG00000186834	HEXIM1	55	55.172	ENSCGRG00000008734	Hexim2	60	53.659	Cricetulus_griseus_crigri
ENSG00000186834	HEXIM1	100	85.515	ENSCGRG00000019550	Hexim1	100	85.515	Cricetulus_griseus_crigri
ENSG00000186834	HEXIM1	55	56.744	ENSCVAG00000012890	hexim1	59	58.140	Cyprinodon_variegatus
ENSG00000186834	HEXIM1	100	83.008	ENSDNOG00000042085	HEXIM1	100	83.008	Dasypus_novemcinctus
ENSG00000186834	HEXIM1	55	54.726	ENSDNOG00000008936	HEXIM2	64	53.234	Dasypus_novemcinctus
ENSG00000186834	HEXIM1	100	88.301	ENSDORG00000014730	Hexim1	100	88.301	Dipodomys_ordii
ENSG00000186834	HEXIM1	51	50.820	ENSDORG00000014731	Hexim2	65	52.970	Dipodomys_ordii
ENSG00000186834	HEXIM1	55	52.525	ENSETEG00000018494	HEXIM2	70	50.500	Echinops_telfairi
ENSG00000186834	HEXIM1	55	47.761	ENSEBUG00000011914	hexim1	63	47.264	Eptatretus_burgeri
ENSG00000186834	HEXIM1	100	90.833	ENSEASG00005010424	HEXIM1	100	90.833	Equus_asinus_asinus
ENSG00000186834	HEXIM1	51	50.273	ENSEASG00005010425	HEXIM2	65	51.232	Equus_asinus_asinus
ENSG00000186834	HEXIM1	51	49.727	ENSECAG00000018388	HEXIM2	67	50.246	Equus_caballus
ENSG00000186834	HEXIM1	100	90.808	ENSECAG00000000859	HEXIM1	100	90.808	Equus_caballus
ENSG00000186834	HEXIM1	60	97.222	ENSEEUG00000011611	HEXIM1	100	97.222	Erinaceus_europaeus
ENSG00000186834	HEXIM1	55	53.266	ENSEEUG00000005259	HEXIM2	67	52.764	Erinaceus_europaeus
ENSG00000186834	HEXIM1	59	51.887	ENSFCAG00000026386	HEXIM2	70	50.467	Felis_catus
ENSG00000186834	HEXIM1	100	90.251	ENSFCAG00000005475	HEXIM1	100	90.251	Felis_catus
ENSG00000186834	HEXIM1	51	80.214	ENSFALG00000009364	HEXIM1	78	77.273	Ficedula_albicollis
ENSG00000186834	HEXIM1	51	56.923	ENSFHEG00000011351	hexim1	68	58.411	Fundulus_heteroclitus
ENSG00000186834	HEXIM1	53	58.621	ENSGMOG00000017844	hexim1	83	61.644	Gadus_morhua
ENSG00000186834	HEXIM1	61	76.818	ENSGALG00000041926	HEXIM1	92	66.065	Gallus_gallus
ENSG00000186834	HEXIM1	55	54.667	ENSGAFG00000002769	hexim1	58	57.944	Gambusia_affinis
ENSG00000186834	HEXIM1	62	87.225	ENSGAGG00000015869	HEXIM1	93	86.842	Gopherus_agassizii
ENSG00000186834	HEXIM1	55	54.229	ENSGGOG00000007926	HEXIM2	65	52.239	Gorilla_gorilla
ENSG00000186834	HEXIM1	100	99.721	ENSGGOG00000014370	HEXIM1	100	99.721	Gorilla_gorilla
ENSG00000186834	HEXIM1	55	58.491	ENSHBUG00000000196	hexim1	58	60.096	Haplochromis_burtoni
ENSG00000186834	HEXIM1	59	87.264	ENSHGLG00000008489	HEXIM1	93	87.264	Heterocephalus_glaber_female
ENSG00000186834	HEXIM1	50	57.360	ENSIPUG00000004319	hexim1	62	61.215	Ictalurus_punctatus
ENSG00000186834	HEXIM1	100	89.694	ENSSTOG00000019464	HEXIM1	100	89.694	Ictidomys_tridecemlineatus
ENSG00000186834	HEXIM1	56	55.941	ENSSTOG00000009448	HEXIM2	67	55.446	Ictidomys_tridecemlineatus
ENSG00000186834	HEXIM1	51	49.727	ENSJJAG00000018759	Hexim2	60	50.746	Jaculus_jaculus
ENSG00000186834	HEXIM1	100	86.464	ENSJJAG00000006094	Hexim1	100	87.017	Jaculus_jaculus
ENSG00000186834	HEXIM1	55	58.852	ENSKMAG00000011029	hexim1	61	60.287	Kryptolebias_marmoratus
ENSG00000186834	HEXIM1	54	56.931	ENSLACG00000003660	-	90	56.716	Latimeria_chalumnae
ENSG00000186834	HEXIM1	52	67.010	ENSLACG00000003325	hexim1	100	66.197	Latimeria_chalumnae
ENSG00000186834	HEXIM1	54	54.128	ENSLOCG00000017511	hexim1	93	48.571	Lepisosteus_oculatus
ENSG00000186834	HEXIM1	56	52.709	ENSLAFG00000014694	HEXIM2	68	51.471	Loxodonta_africana
ENSG00000186834	HEXIM1	100	87.222	ENSLAFG00000022721	HEXIM1	100	87.222	Loxodonta_africana
ENSG00000186834	HEXIM1	55	54.229	ENSMFAG00000032794	HEXIM2	65	52.239	Macaca_fascicularis
ENSG00000186834	HEXIM1	100	98.050	ENSMFAG00000030480	HEXIM1	100	98.050	Macaca_fascicularis
ENSG00000186834	HEXIM1	100	98.050	ENSMMUG00000042910	HEXIM1	100	98.050	Macaca_mulatta
ENSG00000186834	HEXIM1	55	54.229	ENSMMUG00000000713	HEXIM2	65	52.239	Macaca_mulatta
ENSG00000186834	HEXIM1	100	98.050	ENSMNEG00000000901	HEXIM1	100	98.050	Macaca_nemestrina
ENSG00000186834	HEXIM1	55	54.229	ENSMNEG00000032116	HEXIM2	65	52.239	Macaca_nemestrina
ENSG00000186834	HEXIM1	55	54.229	ENSMLEG00000038451	HEXIM2	65	52.239	Mandrillus_leucophaeus
ENSG00000186834	HEXIM1	100	98.050	ENSMLEG00000024845	HEXIM1	100	98.050	Mandrillus_leucophaeus
ENSG00000186834	HEXIM1	55	58.491	ENSMZEG00005022967	hexim1	58	60.096	Maylandia_zebra
ENSG00000186834	HEXIM1	68	93.061	ENSMAUG00000018509	Hexim1	99	93.061	Mesocricetus_auratus
ENSG00000186834	HEXIM1	55	56.281	ENSMAUG00000021720	Hexim2	60	54.726	Mesocricetus_auratus
ENSG00000186834	HEXIM1	55	57.214	ENSMICG00000041666	HEXIM2	66	55.224	Microcebus_murinus
ENSG00000186834	HEXIM1	68	93.469	ENSMOCG00000004118	Hexim1	99	93.469	Microtus_ochrogaster
ENSG00000186834	HEXIM1	55	54.680	ENSMOCG00000007400	Hexim2	60	52.683	Microtus_ochrogaster
ENSG00000186834	HEXIM1	54	51.531	ENSMODG00000024024	HEXIM2	77	51.131	Monodelphis_domestica
ENSG00000186834	HEXIM1	96	71.143	ENSMODG00000011185	HEXIM1	99	69.755	Monodelphis_domestica
ENSG00000186834	HEXIM1	55	56.667	ENSMALG00000009105	hexim1	57	58.095	Monopterus_albus
ENSG00000186834	HEXIM1	100	85.794	MGP_CAROLIEiJ_G0017273	Hexim1	100	85.794	Mus_caroli
ENSG00000186834	HEXIM1	55	55.392	MGP_CAROLIEiJ_G0017274	Hexim2	61	53.202	Mus_caroli
ENSG00000186834	HEXIM1	100	85.794	ENSMUSG00000048878	Hexim1	100	85.794	Mus_musculus
ENSG00000186834	HEXIM1	55	54.902	ENSMUSG00000043372	Hexim2	60	53.171	Mus_musculus
ENSG00000186834	HEXIM1	100	85.794	MGP_PahariEiJ_G0018403	Hexim1	100	85.794	Mus_pahari
ENSG00000186834	HEXIM1	55	56.373	MGP_PahariEiJ_G0018404	Hexim2	60	54.187	Mus_pahari
ENSG00000186834	HEXIM1	55	54.902	MGP_SPRETEiJ_G0018117	Hexim2	60	53.171	Mus_spretus
ENSG00000186834	HEXIM1	100	85.515	MGP_SPRETEiJ_G0018116	Hexim1	100	85.515	Mus_spretus
ENSG00000186834	HEXIM1	100	90.808	ENSMPUG00000019044	HEXIM1	100	90.808	Mustela_putorius_furo
ENSG00000186834	HEXIM1	55	54.726	ENSMPUG00000008646	HEXIM2	59	53.202	Mustela_putorius_furo
ENSG00000186834	HEXIM1	56	51.724	ENSMLUG00000005556	HEXIM2	93	43.686	Myotis_lucifugus
ENSG00000186834	HEXIM1	100	86.667	ENSMLUG00000005554	HEXIM1	100	86.667	Myotis_lucifugus
ENSG00000186834	HEXIM1	100	83.611	ENSNGAG00000004671	Hexim1	100	82.920	Nannospalax_galili
ENSG00000186834	HEXIM1	55	53.695	ENSNGAG00000008154	Hexim2	59	52.217	Nannospalax_galili
ENSG00000186834	HEXIM1	55	58.491	ENSNBRG00000020486	hexim1	58	60.096	Neolamprologus_brichardi
ENSG00000186834	HEXIM1	55	53.234	ENSNLEG00000031095	HEXIM2	65	51.741	Nomascus_leucogenys
ENSG00000186834	HEXIM1	100	99.443	ENSNLEG00000029192	HEXIM1	100	99.443	Nomascus_leucogenys
ENSG00000186834	HEXIM1	55	55.779	ENSOPRG00000012395	HEXIM2	66	53.000	Ochotona_princeps
ENSG00000186834	HEXIM1	60	84.862	ENSODEG00000018098	HEXIM1	96	84.862	Octodon_degus
ENSG00000186834	HEXIM1	54	59.135	ENSONIG00000020929	hexim1	57	59.135	Oreochromis_niloticus
ENSG00000186834	HEXIM1	55	53.769	ENSOCUG00000006750	HEXIM2	60	53.234	Oryctolagus_cuniculus
ENSG00000186834	HEXIM1	100	82.173	ENSOCUG00000006748	HEXIM1	100	79.722	Oryctolagus_cuniculus
ENSG00000186834	HEXIM1	57	56.422	ENSORLG00000023814	hexim1	61	56.364	Oryzias_latipes
ENSG00000186834	HEXIM1	57	56.422	ENSORLG00020010120	hexim1	61	56.364	Oryzias_latipes_hni
ENSG00000186834	HEXIM1	54	57.971	ENSORLG00015002827	hexim1	65	58.454	Oryzias_latipes_hsok
ENSG00000186834	HEXIM1	57	55.708	ENSOMEG00000021356	hexim1	62	56.109	Oryzias_melastigma
ENSG00000186834	HEXIM1	55	56.281	ENSOGAG00000009303	HEXIM2	66	55.000	Otolemur_garnettii
ENSG00000186834	HEXIM1	100	89.694	ENSOGAG00000009304	HEXIM1	100	89.694	Otolemur_garnettii
ENSG00000186834	HEXIM1	55	50.980	ENSOARG00000009856	HEXIM2	75	46.753	Ovis_aries
ENSG00000186834	HEXIM1	55	54.229	ENSPPAG00000009894	HEXIM2	65	52.239	Pan_paniscus
ENSG00000186834	HEXIM1	100	100.000	ENSPPAG00000013758	HEXIM1	100	100.000	Pan_paniscus
ENSG00000186834	HEXIM1	100	90.251	ENSPPRG00000021693	HEXIM1	100	90.251	Panthera_pardus
ENSG00000186834	HEXIM1	59	51.887	ENSPPRG00000001652	HEXIM2	70	50.467	Panthera_pardus
ENSG00000186834	HEXIM1	59	51.887	ENSPTIG00000019231	HEXIM2	70	50.467	Panthera_tigris_altaica
ENSG00000186834	HEXIM1	100	90.251	ENSPTIG00000001145	HEXIM1	100	90.251	Panthera_tigris_altaica
ENSG00000186834	HEXIM1	100	100.000	ENSPTRG00000049378	HEXIM1	100	100.000	Pan_troglodytes
ENSG00000186834	HEXIM1	55	54.229	ENSPTRG00000009299	HEXIM2	65	52.239	Pan_troglodytes
ENSG00000186834	HEXIM1	100	98.050	ENSPANG00000017530	HEXIM1	100	98.050	Papio_anubis
ENSG00000186834	HEXIM1	55	54.229	ENSPANG00000021251	HEXIM2	65	52.239	Papio_anubis
ENSG00000186834	HEXIM1	52	55.072	ENSPKIG00000021934	hexim1	77	49.667	Paramormyrops_kingsleyae
ENSG00000186834	HEXIM1	51	56.345	ENSPKIG00000002959	hexim1	60	57.870	Paramormyrops_kingsleyae
ENSG00000186834	HEXIM1	57	84.541	ENSPSIG00000009902	HEXIM1	100	79.372	Pelodiscus_sinensis
ENSG00000186834	HEXIM1	55	55.779	ENSPEMG00000001356	Hexim2	60	53.731	Peromyscus_maniculatus_bairdii
ENSG00000186834	HEXIM1	65	95.299	ENSPEMG00000001808	Hexim1	70	95.319	Peromyscus_maniculatus_bairdii
ENSG00000186834	HEXIM1	55	53.030	ENSPMAG00000003486	hexim1	94	53.171	Petromyzon_marinus
ENSG00000186834	HEXIM1	100	70.300	ENSPCIG00000015058	HEXIM1	100	70.924	Phascolarctos_cinereus
ENSG00000186834	HEXIM1	54	49.495	ENSPCIG00000015059	HEXIM2	67	50.226	Phascolarctos_cinereus
ENSG00000186834	HEXIM1	55	54.229	ENSPPYG00000008310	HEXIM2	65	52.239	Pongo_abelii
ENSG00000186834	HEXIM1	57	41.262	ENSPCAG00000015843	HEXIM2	70	40.777	Procavia_capensis
ENSG00000186834	HEXIM1	100	76.454	ENSPCAG00000015764	HEXIM1	100	75.549	Procavia_capensis
ENSG00000186834	HEXIM1	69	49.020	ENSPCOG00000008648	HEXIM2	82	47.451	Propithecus_coquereli
ENSG00000186834	HEXIM1	55	54.271	ENSPVAG00000013115	HEXIM2	71	53.000	Pteropus_vampyrus
ENSG00000186834	HEXIM1	55	58.019	ENSPNYG00000012838	hexim1	58	59.615	Pundamilia_nyererei
ENSG00000186834	HEXIM1	51	56.796	ENSPNAG00000005803	hexim1	64	60.000	Pygocentrus_nattereri
ENSG00000186834	HEXIM1	100	85.515	ENSRNOG00000003203	Hexim1	100	85.515	Rattus_norvegicus
ENSG00000186834	HEXIM1	55	54.412	ENSRNOG00000021287	Hexim2	60	52.195	Rattus_norvegicus
ENSG00000186834	HEXIM1	100	98.329	ENSRBIG00000027049	-	100	98.329	Rhinopithecus_bieti
ENSG00000186834	HEXIM1	55	54.229	ENSRBIG00000041800	HEXIM2	65	52.239	Rhinopithecus_bieti
ENSG00000186834	HEXIM1	100	98.050	ENSRROG00000013037	HEXIM1	100	98.050	Rhinopithecus_roxellana
ENSG00000186834	HEXIM1	55	54.229	ENSRROG00000042011	HEXIM2	65	52.239	Rhinopithecus_roxellana
ENSG00000186834	HEXIM1	100	96.936	ENSSBOG00000016824	HEXIM1	100	96.936	Saimiri_boliviensis_boliviensis
ENSG00000186834	HEXIM1	51	51.075	ENSSBOG00000021727	HEXIM2	65	50.746	Saimiri_boliviensis_boliviensis
ENSG00000186834	HEXIM1	100	71.545	ENSSHAG00000010963	HEXIM1	100	70.924	Sarcophilus_harrisii
ENSG00000186834	HEXIM1	51	54.301	ENSSHAG00000011037	HEXIM2	66	54.950	Sarcophilus_harrisii
ENSG00000186834	HEXIM1	52	53.052	ENSSLDG00000000246	hexim1	72	50.000	Seriola_lalandi_dorsalis
ENSG00000186834	HEXIM1	99	62.670	ENSSPUG00000010560	-	100	63.488	Sphenodon_punctatus
ENSG00000186834	HEXIM1	51	56.995	ENSSPAG00000003586	hexim1	58	59.330	Stegastes_partitus
ENSG00000186834	HEXIM1	51	52.128	ENSSSCG00000017335	HEXIM2	79	52.217	Sus_scrofa
ENSG00000186834	HEXIM1	55	53.456	ENSTRUG00000019644	hexim1	61	53.947	Takifugu_rubripes
ENSG00000186834	HEXIM1	52	58.854	ENSTNIG00000000815	hexim1	72	59.596	Tetraodon_nigroviridis
ENSG00000186834	HEXIM1	55	53.202	ENSTTRG00000006285	HEXIM2	66	51.724	Tursiops_truncatus
ENSG00000186834	HEXIM1	55	54.271	ENSUAMG00000024042	HEXIM2	65	52.736	Ursus_americanus
ENSG00000186834	HEXIM1	67	97.107	ENSUAMG00000024043	HEXIM1	98	97.107	Ursus_americanus
ENSG00000186834	HEXIM1	67	97.107	ENSUMAG00000014477	HEXIM1	98	97.107	Ursus_maritimus
ENSG00000186834	HEXIM1	55	50.505	ENSUMAG00000014481	HEXIM2	63	49.000	Ursus_maritimus
ENSG00000186834	HEXIM1	55	53.695	ENSVVUG00000018357	HEXIM2	64	52.195	Vulpes_vulpes
ENSG00000186834	HEXIM1	100	90.251	ENSVVUG00000018324	HEXIM1	100	90.251	Vulpes_vulpes
ENSG00000186834	HEXIM1	55	62.981	ENSXETG00000027237	hexim1	71	61.429	Xenopus_tropicalis
ENSG00000186834	HEXIM1	55	53.778	ENSXCOG00000017406	hexim1	58	57.009	Xiphophorus_couchianus
ENSG00000186834	HEXIM1	55	53.778	ENSXMAG00000008423	hexim1	58	57.477	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	14580347.	IDA	Process
GO:0002218	activation of innate immune response	28712728.	IDA	Process
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	21873635.	IBA	Function
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	14580347.	IDA	Function
GO:0005515	protein binding	12832472.14580347.15713661.15941832.17724342.18281698.18483487.19387490.19883659.20562857.21044950.21533037.23455922.24360279.25470060.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	12581153.28712728.	IDA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	12581153.	IDA	Component
GO:0007507	heart development	-	IEA	Process
GO:0017069	snRNA binding	14580347.	IDA	Function
GO:0045087	innate immune response	-	IEA	Process
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	21873635.	IBA	Process
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	14580347.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	14580347.	IDA	Process
GO:0097322	7SK snRNA binding	21873635.	IBA	Function
GO:0097322	7SK snRNA binding	12832472.19883659.	IDA	Function
GO:1901798	positive regulation of signal transduction by p53 class mediator	22948151.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.