EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29045831	USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination.	Cell Rep	2017 Oct 17	Novellasdemunt L	doi: 10.1016/j.celrep.2017.09.072.
18418047	A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model.	Cell Cycle	2008 May 1	Becker K	-
29574466	Clinical Significance of Ubiquitin Specific Protease 7 (USP7) in Predicting Prognosis of Hepatocellular Carcinoma and its Functional Mechanisms.	Med Sci Monit	2018 Mar 25	Wang X	-
30542736	Ubiquitinspecific protease 7 promotes osteosarcoma cell metastasis by inducing epithelialmesenchymal transition.	Oncol Rep	2019 Jan	Zeng Q	doi: 10.3892/or.2018.6835
22901115	No association between the USP7 gene polymorphisms and colorectal cancer in the Chinese Han population.	Asian Pac J Cancer Prev	2012	Li X	-
26768359	Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells.	Biochem Biophys Res Commun	2016 Jan 29	Lee G	doi: 10.1016/j.bbrc.2016.01.021
24823443	HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator.	FEBS J	2014 Jul	Bhattacharya S	doi: 10.1111/febs.12843
20930542	Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets.	Cancer Biol Ther	2010 Oct 15	Shi D	-
22750444	STAT3 repressed USP7 expression is crucial for colon cancer development.	FEBS Lett	2012 Sep 21	Yang Z	doi: 10.1016/j.febslet.2012.06.025
25695151	FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7.	Mol Med Rep	2015 Jul	Hu HJ	doi: 10.3892/mmr.2015.3362
20855462	Single-nucleotide polymorphisms in p53 pathway and aggressiveness of prostate cancer in a Caucasian population.	Clin Cancer Res	2010 Nov 1	Sun T	doi: 10.1158/1078-0432.CCR-10-1261
18716620	The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.	Nature	2008 Oct 9	Song MS	doi: 10.1038/nature07290
27302477	Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer.	Tohoku J Exp Med	2016 Jul	Zhang L	doi: 10.1620/tjem.239.165.
28406480	WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway.	Cell Death Dis	2017 Apr 13	Sun Y	doi: 10.1038/cddis.2017.162.
28288134	DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.	Oncogene	2017 Aug 17	Hern??ndez-P??rez S	doi: 10.1038/onc.2017.21
28325877	Dual-utility NLS drives RNF169-dependent DNA damage responses.	Proc Natl Acad Sci U S A	2017 Apr 4	An L	doi: 10.1073/pnas.1616602114

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr16	8895692	Missense_Mutation	novel	E957K	0.32
BLCA	chr16	8905188	Splice_Region	novel	L524L	0.08
BLCA	chr16	8923247	Silent	novel	F117F	0.14
BLCA	chr16	8902461	Nonsense_Mutation	NA	R621*	0.49
BLCA	chr16	8920358	Splice_Site	NA	X204_splice	0.39
BLCA	chr16	8905254	Missense_Mutation	novel	D502E	0.11
BLCA	chr16	8903325	Missense_Mutation	NA	F594L	0.2
BLCA	chr16	8894809	Missense_Mutation	novel	D1029G	0.11
BLCA	chr16	8902184	Missense_Mutation	novel	I649V	0.34
BLCA	chr16	8915287	Missense_Mutation	novel	D349N	0.07
BLCA	chr16	8915326	Missense_Mutation	NA	E336K	0.6
BLCA	chr16	8905289	Missense_Mutation	novel	E491K	0.57
BLCA	chr16	8920411	Missense_Mutation	novel	D187N	0.29
BLCA	chr16	8915299	Missense_Mutation	novel	E345Q	0.1
BLCA	chr16	8915522	Missense_Mutation	novel	L304V	0.08
BLCA	chr16	8897033	Missense_Mutation	rs368894909	V929M	0.11
BRCA	chr16	8899750	Missense_Mutation	NA	P773S	0.05
BRCA	chr16	8920414	Missense_Mutation	novel	D186N	0.12
BRCA	chr16	8895059	Missense_Mutation	NA	G1004E	0.42
BRCA	chr16	8895129	Missense_Mutation	NA	D981H	0.26
BRCA	chr16	8923224	Missense_Mutation	novel	S125F	0.09
BRCA	chr16	8897030	Missense_Mutation	novel	E930Q	0.08
BRCA	chr16	8920372	Missense_Mutation	novel	P200A	0.16
BRCA	chr16	8903355	Silent	rs374321309	Y584Y	0.31
BRCA	chr16	8894614	Silent	novel	G1046G	0.09
BRCA	chr16	8908389	Missense_Mutation	NA	R408K	0.15
BRCA	chr16	8915519	Missense_Mutation	NA	D305N	0.14
BRCA	chr16	8894592	Missense_Mutation	novel	D1054H	0.06
CESC	chr16	8923243	Missense_Mutation	novel	L119V	0.28
CESC	chr16	8904491	Missense_Mutation	novel	I550V	0.3
CESC	chr16	8899655	Frame_Shift_Ins	novel	N805*	0.12
CESC	chr16	8915337	Missense_Mutation	novel	I332T	0.49
CESC	chr16	8908438	Missense_Mutation	NA	G392S	0.15
CESC	chr16	8899714	Missense_Mutation	NA	E785K	0.38
CESC	chr16	8930356	Missense_Mutation	NA	V41L	0.33
COAD	chr16	8930383	Missense_Mutation	novel	D32H	0.08
COAD	chr16	8895091	Silent	rs757705172	A993A	0.41
COAD	chr16	8903355	Silent	rs374321309	Y584Y	0.21
COAD	chr16	8904542	Missense_Mutation	rs374207468	D533N	0.3
COAD	chr16	8895649	Missense_Mutation	novel	R971Q	0.36
COAD	chr16	8923294	Missense_Mutation	novel	M102L	0.22
COAD	chr16	8899620	Missense_Mutation	novel	R816I	0.24
COAD	chr16	8910765	Missense_Mutation	NA	A381T	0.29
COAD	chr16	8895060	Missense_Mutation	novel	G1004R	0.06
COAD	chr16	8916502	Splice_Region	NA	V302V	0.31
COAD	chr16	8902182	Silent	rs113373249	I649I	0.08
COAD	chr16	8894038	Missense_Mutation	novel	R1090H	0.23
COAD	chr16	8920359	Missense_Mutation	NA	A204V	0.36
COAD	chr16	8898628	Missense_Mutation	NA	G848V	0.34
COAD	chr16	8899720	Missense_Mutation	NA	A783T	0.31
COAD	chr16	8904506	Nonsense_Mutation	novel	Q545*	0.41
COAD	chr16	8895150	Nonsense_Mutation	NA	E974*	0.18
COAD	chr16	8923320	Missense_Mutation	NA	R93Q	0.45
COAD	chr16	8904545	Missense_Mutation	novel	T532A	0.14
COAD	chr16	8895714	Silent	novel	I949I	0.13
COAD	chr16	8902461	Nonsense_Mutation	NA	R621*	0.17
COAD	chr16	8906578	Nonsense_Mutation	NA	E426*	0.13
COAD	chr16	8895096	Missense_Mutation	novel	V992M	0.34
COAD	chr16	8919069	Silent	novel	L228L	0.34
COAD	chr16	8923321	Nonsense_Mutation	NA	R93*	0.31
COAD	chr16	8910767	Missense_Mutation	NA	D380G	0.26
COAD	chr16	8906535	Frame_Shift_Ins	novel	*T440Nfs4**	0.17
ESCA	chr16	8903349	Missense_Mutation	novel	E586D	0.34
ESCA	chr16	8906535	Frame_Shift_Ins	novel	*T440Nfs4**	0.31
ESCA	chr16	8895669	Frame_Shift_Ins	novel	*A965Cfs23**	0.18
GBM	chr16	8898546	Missense_Mutation	novel	K875N	0.21
GBM	chr16	8900620	Missense_Mutation	novel	P740L	0.17
GBM	chr16	8905238	Nonsense_Mutation	novel	R508*	0.22
GBM	chr16	8905313	Missense_Mutation	novel	D483N	0.13
GBM	chr16	8923305	Frame_Shift_Ins	novel	*K98Rfs27**	0.08
GBM	chr16	8921228	Missense_Mutation	novel	S151C	0.19
GBM	chr16	8904550	Missense_Mutation	rs763719614	A530V	0.4
HNSC	chr16	8915460	Missense_Mutation	novel	F324L	0.26
HNSC	chr16	8895727	Missense_Mutation	novel	V945A	0.26
HNSC	chr16	8905319	Missense_Mutation	NA	D481H	0.23
HNSC	chr16	8904494	Missense_Mutation	novel	R549G	0.08
HNSC	chr16	8895734	Missense_Mutation	NA	E943Q	0.4
HNSC	chr16	8904475	Missense_Mutation	novel	R555Q	0.17
HNSC	chr16	8897033	Missense_Mutation	novel	V929L	0.05
KIRC	chr16	8902170	Silent	rs761788371	D653D	0.06
KIRC	chr16	8917129	Missense_Mutation	NA	D250N	0.25
KIRC	chr16	8893885	3'UTR	novel		0.2
LGG	chr16	8920387	Missense_Mutation	novel	V195L	0.4
LGG	chr16	8895109	Silent	novel	E987E	0.04
LGG	chr16	8894843	Nonsense_Mutation	novel	R1018*	0.43
LGG	chr16	8904513	Missense_Mutation	novel	E542D	0.53
LGG	chr16	8910768	Missense_Mutation	novel	D380N	0.54
LGG	chr16	8917043	Frame_Shift_Ins	novel	*L279Vfs12**	0.29
LGG	chr16	8906567	Silent	NA	E429E	0.53
LGG	chr16	8897030	Missense_Mutation	novel	E930K	0.05
LIHC	chr16	8906542	Nonsense_Mutation	NA	Q438*	0.54
LIHC	chr16	8895645	Missense_Mutation	novel	I972M	0.27
LIHC	chr16	8963274	Missense_Mutation	rs750093857	Q4H	0.22
LIHC	chr16	8894850	Missense_Mutation	NA	E1015D	0.37
LIHC	chr16	8898592	Missense_Mutation	novel	T860I	0.48
LUAD	chr16	8893975	3'UTR	novel		0.1
LUAD	chr16	8915314	Missense_Mutation	NA	R340W	0.3
LUAD	chr16	8894832	Missense_Mutation	NA	M1021I	0.33
LUAD	chr16	8910799	Silent	novel	A369A	0.17
LUAD	chr16	8903356	Missense_Mutation	novel	Y584C	0.14
LUAD	chr16	8910761	Missense_Mutation	novel	G382V	0.22
LUAD	chr16	8902127	Nonsense_Mutation	NA	E668*	0.1
LUAD	chr16	8923216	Missense_Mutation	novel	T128A	0.13
LUAD	chr16	8915456	Missense_Mutation	NA	G326C	0.29
LUAD	chr16	8899684	Missense_Mutation	NA	D795N	0.11
LUAD	chr16	8905237	Missense_Mutation	NA	R508L	0.13
LUAD	chr16	8919117	Missense_Mutation	NA	G212C	0.24
LUAD	chr16	8895115	Silent	NA	E985E	0.1
LUAD	chr16	8899165	Missense_Mutation	NA	R829S	0.27
LUAD	chr16	8905250	Missense_Mutation	NA	D504Y	0.08
LUAD	chr16	8899633	Missense_Mutation	NA	T812S	0.33
LUAD	chr16	8905319	Missense_Mutation	NA	D481H	0.16
LUSC	chr16	8901193	Missense_Mutation	NA	R697W	0.13
LUSC	chr16	8903304	Silent	novel	S601S	0.14
LUSC	chr16	8919093	Nonsense_Mutation	novel	G220*	0.45
LUSC	chr16	8899651	Missense_Mutation	NA	D806Y	0.29
LUSC	chr16	8899628	Silent	rs148541392	L813L	0.11
LUSC	chr16	8904466	Missense_Mutation	novel	R558L	0.47
LUSC	chr16	8915455	Missense_Mutation	novel	G326V	0.16
LUSC	chr16	8895068	Missense_Mutation	NA	G1001E	0.32
LUSC	chr16	8917056	Missense_Mutation	novel	V274A	0.23
LUSC	chr16	8919051	Missense_Mutation	NA	F234V	0.06
LUSC	chr16	8904461	Missense_Mutation	novel	E560K	0.29
LUSC	chr16	8902391	Missense_Mutation	NA	G644A	0.47
LUSC	chr16	8897081	Missense_Mutation	novel	D913N	0.19
LUSC	chr16	8898423	Silent	NA	I885I	0.18
MESO	chr16	8904466	Missense_Mutation	novel	R558Q	0.25
OV	chr16	8897017	Missense_Mutation	NA	K934I	0.51
OV	chr16	8897084	Missense_Mutation	novel	P912A	0.05
OV	chr16	8898374	Nonsense_Mutation	novel	Q902*	0.03
OV	chr16	8894588	Missense_Mutation	NA	E1055G	0.54
OV	chr16	8895082	Silent	rs754178330	H996H	0.57
OV	chr16	8895734	Missense_Mutation	NA	E943Q	0.3
OV	chr16	8902449	Missense_Mutation	novel	M625L	0.13
OV	chr16	8921221	Missense_Mutation	NA	R153P	0.35
OV	chr16	8920401	Missense_Mutation	NA	T190I	0.3
OV	chr16	8905259	Missense_Mutation	NA	H501Y	0.66
PAAD	chr16	8899721	Silent	rs372148483	T782T	0.22
PAAD	chr16	8902082	Missense_Mutation	NA	H683Y	0.05
PRAD	chr16	8895682	Missense_Mutation	novel	E960A	0.11
PRAD	chr16	8895069	Missense_Mutation	novel	G1001R	0.39
READ	chr16	8893912	3'UTR	novel		0.24
READ	chr16	8900548	Missense_Mutation	novel	D764G	0.17
READ	chr16	8894007	Missense_Mutation	NA	I1100M	0.11
READ	chr16	8923287	Missense_Mutation	NA	R104H	0.29
READ	chr16	8898564	Silent	NA	K869K	0.23
READ	chr16	8898357	Splice_Region	novel		0.35
READ	chr16	8906516	Silent	NA	A446A	0.39
READ	chr16	8921195	Nonsense_Mutation	NA	E162*	0.43
SARC	chr16	8910769	Silent	rs35018235	Y379Y	0.78
SARC	chr16	8894801	Missense_Mutation	novel	E1032K	0.14
SKCM	chr16	8902146	Silent	NA	F661F	0.22
SKCM	chr16	8902117	Missense_Mutation	NA	A671V	0.27
SKCM	chr16	8902421	Missense_Mutation	NA	R634Q	0.52
SKCM	chr16	8902082	Missense_Mutation	NA	H683Y	0.61
SKCM	chr16	8917137	Missense_Mutation	novel	T247I	0.5
SKCM	chr16	8902421	Missense_Mutation	NA	R634Q	0.44
SKCM	chr16	8894078	Silent	NA	L1077L	0.22
SKCM	chr16	8917122	Missense_Mutation	rs752857703	S252L	0.32
SKCM	chr16	8906524	Missense_Mutation	novel	D444Y	0.4
SKCM	chr16	8906525	Silent	novel	K443K	0.4
SKCM	chr16	8899688	Silent	rs749014851	R793R	0.55
SKCM	chr16	8919121	Silent	rs753887425	H210H	0.42
SKCM	chr16	8919122	Missense_Mutation	novel	H210L	0.42
SKCM	chr16	8906529	Missense_Mutation	novel	P442L	0.26
SKCM	chr16	8902178	Missense_Mutation	NA	L651F	0.07
SKCM	chr16	8902082	Missense_Mutation	NA	H683Y	0.39
SKCM	chr16	8906430	Missense_Mutation	NA	G475A	0.45
SKCM	chr16	8900620	Missense_Mutation	novel	P740L	0.16
SKCM	chr16	8906442	Missense_Mutation	NA	P471L	0.18
SKCM	chr16	8901153	Missense_Mutation	novel	S710F	0.14
SKCM	chr16	8904530	Missense_Mutation	novel	P537S	0.42
SKCM	chr16	8915519	Missense_Mutation	NA	D305N	0.39
SKCM	chr16	8920396	Missense_Mutation	NA	E192K	0.21
SKCM	chr16	8894823	Silent	NA	I1024I	0.25
SKCM	chr16	8923347	Missense_Mutation	novel	S84L	0.35
SKCM	chr16	8895085	Silent	NA	F995F	0.38
SKCM	chr16	8902422	Nonsense_Mutation	NA	R634*	0.17
SKCM	chr16	8893994	3'UTR	rs747295641		0.28
SKCM	chr16	8893952	3'UTR	rs555194723		0.43
SKCM	chr16	8915336	Silent	NA	I332I	0.29
SKCM	chr16	8902461	Nonsense_Mutation	NA	R621*	0.33
SKCM	chr16	8900558	Missense_Mutation	NA	M761L	0.1
STAD	chr16	8915257	Missense_Mutation	NA	N359Y	0.15
STAD	chr16	8902396	Silent	rs140316737	A642A	0.26
STAD	chr16	8894095	Missense_Mutation	NA	S1071F	0.15
STAD	chr16	8915270	Missense_Mutation	NA	I354M	0.19
STAD	chr16	8923247	Missense_Mutation	NA	F117L	0.15
STAD	chr16	8906535	Frame_Shift_Ins	novel	*T440Nfs4**	0.35
STAD	chr16	8923310	Silent	rs773674539	P96P	0.51
STAD	chr16	8894069	Missense_Mutation	NA	D1080N	0.23
STAD	chr16	8895112	Silent	NA	N986N	0.35
STAD	chr16	8905251	Silent	rs776078669	D503D	0.37
STAD	chr16	8894588	Missense_Mutation	NA	E1055A	0.43
STAD	chr16	8906551	Nonsense_Mutation	NA	E435*	0.3
STAD	chr16	8902120	Missense_Mutation	novel	A670D	0.42
STAD	chr16	8910780	Missense_Mutation	novel	D376N	0.46
STAD	chr16	8895091	Silent	rs757705172	A993A	0.09
STAD	chr16	8906535	Frame_Shift_Del	novel	*T440Kfs30**	0.26
STAD	chr16	8894004	Silent	NA	H1101H	0.09
STAD	chr16	8899649	In_Frame_Del	novel	D806del	0.12
STAD	chr16	8901172	Missense_Mutation	NA	H704Y	0.09
STAD	chr16	8900994	Missense_Mutation	novel	Y735C	0.35
STAD	chr16	8894783	Splice_Site	NA	X1037_splice	0.27
STAD	chr16	8920409	Silent	NA	D187D	0.27
STAD	chr16	8904476	Missense_Mutation	NA	R555W	0.08
STAD	chr16	8902391	Missense_Mutation	novel	G644D	0.28
STAD	chr16	8900588	Missense_Mutation	NA	V751M	0.3
UCEC	chr16	8900619	Silent	rs747684595	P740P	0.39
UCEC	chr16	8900619	Silent	rs747684595	P740P	0.21
UCEC	chr16	8893707	3'UTR	rs543567847		0.35
UCEC	chr16	8894069	Missense_Mutation	NA	D1080N	0.41
UCEC	chr16	8899705	Nonsense_Mutation	NA	R788*	0.22
UCEC	chr16	8901031	Missense_Mutation	novel	R723G	0.12
UCEC	chr16	8919083	Missense_Mutation	novel	C223Y	0.12
UCEC	chr16	8921221	Missense_Mutation	novel	R153H	0.34
UCEC	chr16	8915473	Missense_Mutation	novel	I320T	0.05
UCEC	chr16	8902395	Missense_Mutation	rs761125187	D643N	0.05
UCEC	chr16	8904462	Missense_Mutation	novel	Q559H	0.4
UCEC	chr16	8903304	Silent	rs146507622	S601S	0.37
UCEC	chr16	8930312	Silent	rs188450052	A55A	0.49
UCEC	chr16	8930313	Missense_Mutation	rs560277695	A55V	0.4
UCEC	chr16	8895070	Silent	rs200702953	F1000F	0.29
UCEC	chr16	8903354	Missense_Mutation	novel	D585N	0.07
UCEC	chr16	8899631	Silent	rs765786478	T812T	0.25
UCEC	chr16	8921232	Silent	rs781494085	S149S	0.36
UCEC	chr16	8893912	3'UTR	novel		0.11
UCEC	chr16	8902395	Missense_Mutation	rs761125187	D643N	0.44
UCEC	chr16	8919035	Missense_Mutation	NA	R239Q	0.19
UCEC	chr16	8923320	Missense_Mutation	NA	R93Q	0.47
UCEC	chr16	8923320	Missense_Mutation	NA	R93Q	0.47
UCEC	chr16	8936688	Intron	novel		0.5
UCEC	chr16	8923401	Missense_Mutation	novel	R66H	0.17
UCEC	chr16	8917093	Frame_Shift_Del	novel	*R262Sfs4**	0.24
UCEC	chr16	8904512	Nonsense_Mutation	novel	R543*	0.41
UCEC	chr16	8915313	Missense_Mutation	novel	R340Q	0.29
UCEC	chr16	8923258	Frame_Shift_Del	novel	*S114Afs2**	0.55
UCEC	chr16	8901013	Missense_Mutation	novel	D729Y	0.36
UCEC	chr16	8920430	Missense_Mutation	novel	E180D	0.43
UCEC	chr16	8895658	Missense_Mutation	novel	R968Q	0.42
UCEC	chr16	8894102	Missense_Mutation	NA	N1069D	0.33
UCEC	chr16	8903304	Silent	rs146507622	S601S	0.21
UCEC	chr16	8915459	Missense_Mutation	rs765536244	R325C	0.37
UCEC	chr16	8923272	Missense_Mutation	novel	R109K	0.24
UCEC	chr16	8903321	Missense_Mutation	novel	V596I	0.46
UCEC	chr16	8894063	Missense_Mutation	novel	F1082L	0.51
UCEC	chr16	8921224	Missense_Mutation	novel	R152P	0.3
UCEC	chr16	8894594	Missense_Mutation	novel	E1053G	0.44
UCEC	chr16	8893784	3'UTR	novel		0.32
UCEC	chr16	8895123	Missense_Mutation	novel	D983Y	0.31
UCEC	chr16	8910769	Silent	rs35018235	Y379Y	0.46
UCEC	chr16	8898401	Missense_Mutation	novel	S893R	0.2
UCEC	chr16	8910790	Missense_Mutation	novel	Q372H	0.35
UCEC	chr16	8923346	Silent	rs376640584	S84S	0.26
UCEC	chr16	8930397	Missense_Mutation	rs370070575	A27V	0.23
UCEC	chr16	8895657	Silent	NA	R968R	0.27
UCEC	chr16	8899687	Missense_Mutation	NA	V794I	0.38
UCEC	chr16	8923331	Silent	rs767149020	P89P	0.1
UCEC	chr16	8901194	Silent	rs376595760	T696T	0.11
UCEC	chr16	8902396	Silent	rs140316737	A642A	0.04
UCEC	chr16	8902438	Silent	novel	R628R	0.38
UCEC	chr16	8902461	Silent	rs374224337	R621R	0.24
UCEC	chr16	8901013	Missense_Mutation	novel	D729Y	0.05
UCEC	chr16	8894038	Missense_Mutation	novel	R1090H	0.12
UCEC	chr16	8921232	Silent	rs781494085	S149S	0.3
UCEC	chr16	8920359	Missense_Mutation	NA	A204V	0.19
UCEC	chr16	8923313	Silent	rs759100414	L95L	0.43
UCEC	chr16	8923400	Silent	novel	R66R	0.48
UCS	chr16	8905238	In_Frame_Del	novel	D504_R508delinsG	0.56
UCS	chr16	8893928	3'UTR	novel		0.39
UCS	chr16	8895705	Silent	novel	V952V	0.23

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.1618	6.162e-06
CHOL	DEL	0.1111	0.23475

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0042	Kaplan-Meier Survival Analysis
KIRC	0.0015	Kaplan-Meier Survival Analysis
SARC	0.043	Kaplan-Meier Survival Analysis
COAD	0.044	Kaplan-Meier Survival Analysis
READ	0.00049	Kaplan-Meier Survival Analysis
UCEC	0.00061	Kaplan-Meier Survival Analysis
LGG	0.031	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000187555 (Gene tree)
Gene ID: 7874
Gene Symbol: USP7
Alias: HAUSP
Full Name: ubiquitin specific peptidase 7
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 72,421 bases
Position: chr16:8,892,094-8,964,514
Accession: 12630
RBP type: non-canonical RBP
Summary: The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17927229	Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7.	J Proteome Res	2007 Nov	Kessler BM	-
26074452	Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma.	Aquat Toxicol	2015 Aug	Tse AC	doi: 10.1016/j.aquatox.2015.06.002

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000566224	USP7-214	503	-	-	- (aa)	-	-
ENST00000567113	USP7-216	448	-	-	- (aa)	-	-
ENST00000565455	USP7-210	3554	-	ENSP00000456258	47 (aa)	-	H3BRI4
ENST00000563043	USP7-206	332	-	ENSP00000459594	68 (aa)	-	I3L2D8
ENST00000569448	USP7-220	698	-	-	- (aa)	-	-
ENST00000569230	USP7-219	569	-	ENSP00000457237	117 (aa)	-	H3BTM1
ENST00000542333	USP7-203	1966	-	ENSP00000439272	509 (aa)	-	F5H2X1
ENST00000566004	USP7-212	559	-	ENSP00000456150	130 (aa)	-	H3BRA2
ENST00000570256	USP7-221	591	-	-	- (aa)	-	-
ENST00000564117	USP7-209	479	-	ENSP00000457815	109 (aa)	-	H3BUV0
ENST00000565883	USP7-211	453	-	-	- (aa)	-	-
ENST00000562051	USP7-204	567	-	-	- (aa)	-	-
ENST00000567329	USP7-217	567	-	-	- (aa)	-	-
ENST00000344836	USP7-201	5412	XM_017023652	ENSP00000343535	1102 (aa)	XP_016879141	Q93009
ENST00000563085	USP7-207	3194	-	ENSP00000454795	909 (aa)	-	H3BND8
ENST00000566131	USP7-213	569	-	-	- (aa)	-	-
ENST00000566273	USP7-215	577	-	ENSP00000455719	159 (aa)	-	H3BQD1
ENST00000567692	USP7-218	313	-	ENSP00000458027	17 (aa)	-	H3BVA7
ENST00000381886	USP7-202	3587	XM_017023653	ENSP00000371310	1086 (aa)	XP_016879142	Q93009
ENST00000562615	USP7-205	304	-	-	- (aa)	-	-
ENST00000563961	USP7-208	4533	-	ENSP00000454362	91 (aa)	-	H3BMF6

Gene Model

Click here to download ENSG00000187555's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04068	FoxO signaling pathway	KEGG
hsa05169	Epstein-Barr virus infection	KEGG
hsa05203	Viral carcinogenesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000187555	Heart Failure	9.6622427E-004	-
ENSG00000187555	Hypertrophy, Left Ventricular	1.5140000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000187555	rs183725	16	8954178	C	Platelet count	27863252	[0.017-0.035] unit increase	0.02599643	EFO_0004309
ENSG00000187555	rs7190551	16	8938158	A	Platelet distribution width	27863252	[0.024-0.043] unit increase	0.0334153	EFO_0007984
ENSG00000187555	rs11551183	16	8894835	G	Macrophage Migration Inhibitory Factor levels	27989323	[0.22-0.53] SD units decrease	0.3715	EFO_0008221
ENSG00000187555	rs141361914	16	8941610	?	Eosinophil counts	30595370			EFO_0004842
ENSG00000187555	rs2304467	16	8894920	G	Chronotype	30696823		1.0239831	EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000187555's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000187555	USP7	92	66.173	FBgn0030366	Usp7	95	48.584	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002039	p53 binding	20096447.	IDA	Function
GO:0004197	cysteine-type endopeptidase activity	21873635.	IBA	Function
GO:0004197	cysteine-type endopeptidase activity	21745816.	IMP	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	21873635.	IBA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	16964248.21745816.26280536.	IDA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	11923872.	IMP	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	-	TAS	Function
GO:0005515	protein binding	11279055.11923872.15916963.16402859.16474402.16713569.16845383.17268548.17936559.18566590.18716620.18729074.20601937.20697359.21170034.21745816.21988832.22056774.22466611.22466612.22653443.22810586.22863774.24823443.25172512.25266658.25544563.26496610.26678539.27123980.	IPI	Function
GO:0005634	nucleus	16791210.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11279055.12093161.16964248.18410486.20096447.26678539.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	IEA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	11279055.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006283	transcription-coupled nucleotide-excision repair	22466612.	IMP	Process
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006511	ubiquitin-dependent protein catabolic process	-	IEA	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0008022	protein C-terminus binding	12093161.	IPI	Function
GO:0008134	transcription factor binding	21873635.	IBA	Function
GO:0008134	transcription factor binding	16964248.	IPI	Function
GO:0010216	maintenance of DNA methylation	21745816.	IMP	Process
GO:0016032	viral process	-	IEA	Process
GO:0016567	protein ubiquitination	-	TAS	Process
GO:0016579	protein deubiquitination	21873635.	IBA	Process
GO:0016579	protein deubiquitination	16964248.21745816.25172512.	IDA	Process
GO:0016579	protein deubiquitination	11923872.18410486.26678539.27123980.	IMP	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0016604	nuclear body	16791210.	HDA	Component
GO:0016605	PML body	-	IEA	Component
GO:0031625	ubiquitin protein ligase binding	11279055.18410486.18566590.	IPI	Function
GO:0031647	regulation of protein stability	21873635.	IBA	Process
GO:0031647	regulation of protein stability	27123980.	IDA	Process
GO:0032088	negative regulation of NF-kappaB transcription factor activity	11279055.	IDA	Process
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	26678539.	IMP	Process
GO:0032991	protein-containing complex	26678539.	IDA	Component
GO:0035520	monoubiquitinated protein deubiquitination	26280536.	IDA	Process
GO:0035616	histone H2B conserved C-terminal lysine deubiquitination	-	ISS	Process
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	21745816.	IDA	Function
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	26678539.	IMP	Function
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	-	TAS	Function
GO:0042752	regulation of circadian rhythm	27123980.	IDA	Process
GO:0050821	protein stabilization	25172512.	IDA	Process
GO:0050821	protein stabilization	18410486.	IMP	Process
GO:0051090	regulation of DNA-binding transcription factor activity	21873635.	IBA	Process
GO:0051090	regulation of DNA-binding transcription factor activity	16964248.	IDA	Process
GO:0071108	protein K48-linked deubiquitination	-	IEA	Process
GO:0101005	ubiquitinyl hydrolase activity	18410486.	IMP	Function
GO:1901537	positive regulation of DNA demethylation	25944111.	IDA	Process
GO:1904353	regulation of telomere capping	25172512.	TAS	Process
GO:1990380	Lys48-specific deubiquitinase activity	25944111.	IDA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.