EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29895858	A homozygous FANCM frameshift pathogenic variant causes male infertility.	Genet Med	2019 Jan	Yin H	doi: 10.1038/s41436-018-0015-7
28033443	Association Between Loss-of-Function Mutations Within the FANCM Gene and Early-Onset Familial Breast Cancer.	JAMA Oncol	2017 Sep 1	Neidhardt G	doi: 10.1001/jamaoncol.2016.5592.
25288723	Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer.	Proc Natl Acad Sci U S A	2014 Oct 21	Kiiski JI	doi: 10.1073/pnas.1407909111
28702895	FANCM mutation c.5791C>T is a risk factor for triple-negative breast cancer in the Finnish population.	Breast Cancer Res Treat	2017 Nov	Kiiski JI	doi: 10.1007/s10549-017-4388-0
26130695	FANCM c.5791C>T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor.	Hum Mol Genet	2015 Sep 15	Peterlongo P	doi: 10.1093/hmg/ddv251
20160754	FANCM: fork pause, rewind and play.	EMBO J	2010 Feb 17	Collis SJ	doi: 10.1038/emboj.2009.415.
19737859	Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition.	Carcinogenesis	2009 Nov	Garcia MJ	doi: 10.1093/carcin/bgp218
26067930	Absence of the FANCM c.5101C>T mutation in BRCA1/2-negative triple-negative breast cancer patients from Pakistan.	Breast Cancer Res Treat	2015 Jul	Rashid MU	doi: 10.1007/s10549-015-3457-5
27542569	FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome.	Int J Cancer	2016 Dec 15	Kiiski JI	doi: 10.1002/ijc.30394
29287190	A possible role of FANCM mutations in male breast cancer susceptibility: Results from a multicenter study in Italy.	Breast	2018 Apr	Silvestri V	doi: 10.1016/j.breast.2017.12.013
28837157	Biallelic truncating FANCM mutations cause early-onset cancer but not Fanconi anemia.	Genet Med	2018 Apr	Bogliolo M	doi: 10.1038/gim.2017.124
28837162	Individuals with FANCM biallelic mutations do not develop Fanconi anemia, but show risk for breast cancer, chemotherapy toxicity and may display chromosome fragility.	Genet Med	2018 Apr	Catucci I	doi: 10.1038/gim.2017.123
29388117	Correlation of FANCM expression with clinical factors in luminal B breast cancer.	Breast Cancer	2018 Jul	Wang Y	doi: 10.1007/s12282-018-0841-0
29351780	FANCM and RECQL genetic variants and breast cancer susceptibility: relevance to South Poland and West Ukraine.	BMC Med Genet	2018 Jan 19	Nguyen-Dumont T	doi: 10.1186/s12881-018-0524-x.
30075111	Bi-allelic Recessive Loss-of-Function Variants in FANCM Cause Non-obstructive Azoospermia.	Am J Hum Genet	2018 Aug 2	Kasak L	doi: 10.1016/j.ajhg.2018.07.005.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr14	45176458	Missense_Mutation	rs146490925	G1235V	0.33
ACC	chr14	45175397	Silent	novel	D881D	0.33
ACC	chr14	45170606	Missense_Mutation	novel	L674I	0.31
BLCA	chr14	45185281	Missense_Mutation	novel	S1527L	0.31
BLCA	chr14	45154710	Frame_Shift_Del	novel	*N401Mfs10**	0.45
BLCA	chr14	45198838	Missense_Mutation	NA	E1971K	0.86
BLCA	chr14	45188960	Silent	NA	A1646A	0.19
BLCA	chr14	45136128	Nonsense_Mutation	novel	Q33*	0.53
BLCA	chr14	45189230	Silent	NA	L1736L	0.08
BLCA	chr14	45136293	Missense_Mutation	novel	N88Y	0.14
BLCA	chr14	45136294	Missense_Mutation	novel	N88I	0.14
BLCA	chr14	45176246	Missense_Mutation	novel	K1164N	0.41
BLCA	chr14	45189198	Missense_Mutation	NA	P1726A	0.25
BLCA	chr14	45189066	Missense_Mutation	novel	D1682H	0.05
BLCA	chr14	45175513	Missense_Mutation	novel	P920R	0.07
BLCA	chr14	45173204	Silent	rs566935444	H770H	0.19
BLCA	chr14	45136066	Nonsense_Mutation	NA	W12*	0.34
BLCA	chr14	45173095	Missense_Mutation	NA	S734C	0.31
BLCA	chr14	45176181	Missense_Mutation	novel	E1143K	0.13
BLCA	chr14	45154762	Missense_Mutation	rs141729590	E417Q	0.2
BLCA	chr14	45136269	Missense_Mutation	novel	G80R	0.21
BLCA	chr14	45136059	Missense_Mutation	rs757266508	Q10E	0.08
BLCA	chr14	45154011	Missense_Mutation	rs765686151	S381L	0.53
BLCA	chr14	45175826	Silent	NA	P1024P	0.51
BLCA	chr14	45176324	Silent	NA	L1190L	0.42
BLCA	chr14	45136268	Silent	NA	A79A	0.25
BLCA	chr14	45175559	Silent	novel	S935S	0.29
BLCA	chr14	45167121	Missense_Mutation	rs112784867	R654W	0.23
BRCA	chr14	45137191	Missense_Mutation	NA	L211I	0.32	ResIII
BRCA	chr14	45183890	Silent	novel	Q1501Q	0.14
BRCA	chr14	45175529	Silent	NA	T925T	0.62
BRCA	chr14	45136064	Silent	novel	T11T	0.54
BRCA	chr14	45196471	Silent	NA	F1880F	0.19
BRCA	chr14	45175171	Frame_Shift_Ins	novel	D807*	0.41
BRCA	chr14	45196254	Missense_Mutation	rs745769239	S1808Y	0.18
CESC	chr14	45175245	Nonsense_Mutation	novel	E831*	0.32
CESC	chr14	45167056	Missense_Mutation	novel	G632E	0.26
CESC	chr14	45176877	Nonsense_Mutation	novel	E1375*	0.08
CESC	chr14	45167165	Splice_Site	novel	X668_splice	0.42
CESC	chr14	45154777	Missense_Mutation	rs150574630	R422C	0.53
CESC	chr14	45136337	Frame_Shift_Ins	novel	*L103Pfs82**	0.07
CESC	chr14	45173061	Missense_Mutation	novel	E723K	0.21
CESC	chr14	45173204	Silent	rs566935444	H770H	0.26
CESC	chr14	45196352	Missense_Mutation	novel	H1841Y	0.16
CESC	chr14	45176166	Missense_Mutation	novel	E1138K	0.25
CESC	chr14	45176529	Missense_Mutation	novel	L1259V	0.3
CESC	chr14	45173074	Missense_Mutation	novel	G727E	0.18
COAD	chr14	45188890	Missense_Mutation	NA	V1623G	0.29
COAD	chr14	45175352	Frame_Shift_Ins	novel	*E869Rfs3**	0.21
COAD	chr14	45175316	Missense_Mutation	NA	K854N	0.5
COAD	chr14	45198892	Missense_Mutation	NA	N1989H	0.43
COAD	chr14	45151468	Frame_Shift_Del	novel	*K331Nfs4**	0.13
COAD	chr14	45155385	Missense_Mutation	novel	K441T	0.11
COAD	chr14	45175784	Missense_Mutation	novel	E1010D	0.29
COAD	chr14	45176619	Missense_Mutation	NA	F1289V	0.17
COAD	chr14	45136127	Silent	novel	P32P	0.09
COAD	chr14	45176134	Missense_Mutation	NA	S1127C	0.14
COAD	chr14	45154784	Missense_Mutation	rs139726733	R424H	0.33
COAD	chr14	45200014	3'UTR	rs762727997		0.06
COAD	chr14	45154040	Missense_Mutation	novel	D391N	0.23
COAD	chr14	45136159	Missense_Mutation	rs767799451	P43L	0.19
COAD	chr14	45137202	Silent	novel	D214D	0.04
COAD	chr14	45176795	Missense_Mutation	novel	L1347F	0.06
COAD	chr14	45167133	Nonsense_Mutation	rs368728266	R658*	0.26
COAD	chr14	45159218	Missense_Mutation	NA	T507S	0.7
COAD	chr14	45196410	Missense_Mutation	rs776506025	R1860H	0.3
COAD	chr14	45189108	Missense_Mutation	novel	K1696E	0.04
COAD	chr14	45198839	Missense_Mutation	NA	E1971G	0.42
COAD	chr14	45136266	Missense_Mutation	NA	A79T	0.21
COAD	chr14	45136388	Silent	NA	F119F	0.15
COAD	chr14	45187810	Missense_Mutation	novel	S1568P	0.07
COAD	chr14	45189004	Missense_Mutation	NA	K1661T	0.15
COAD	chr14	45196509	Missense_Mutation	NA	R1893I	0.1
COAD	chr14	45155416	Missense_Mutation	rs771239660	K451N	0.26
COAD	chr14	45176856	Missense_Mutation	NA	V1368L	0.29
COAD	chr14	45176186	Silent	rs374047969	F1144F	0.28
COAD	chr14	45136017	5'UTR	novel		0.13
COAD	chr14	45176581	Missense_Mutation	rs753876341	S1276L	0.25
COAD	chr14	45176190	Missense_Mutation	rs142077813	D1146N	0.36
COAD	chr14	45167101	Missense_Mutation	NA	Y647C	0.55
COAD	chr14	45154706	Missense_Mutation	rs530233908	R398Q	0.35
COAD	chr14	45189124	Missense_Mutation	rs758177952	Q1701R	0.21
DLBC	chr14	45155447	Nonsense_Mutation	novel	K462*	0.32
ESCA	chr14	45198925	Missense_Mutation	novel	M2000L	0.64
ESCA	chr14	45175188	Missense_Mutation	novel	H812D	0.1
ESCA	chr14	45175085	Silent	novel	Y777Y	0.26
ESCA	chr14	45200075	3'UTR	novel		0.15
ESCA	chr14	45154016	Missense_Mutation	rs766761905	Y383H	0.44
ESCA	chr14	45137235	Silent	novel	Y225Y	0.76
ESCA	chr14	45198759	Missense_Mutation	novel	L1944F	0.24
ESCA	chr14	45173061	Missense_Mutation	novel	E723K	0.27
ESCA	chr14	45154759	Silent	novel	L416L	0.28
ESCA	chr14	45159197	Nonsense_Mutation	novel	Q500*	0.23
ESCA	chr14	45176752	Frame_Shift_Del	rs746983128	*V1336Lfs2**	0.36
ESCA	chr14	45200108	3'UTR	novel		0.31
ESCA	chr14	45176370	Nonsense_Mutation	NA	Q1206*	0.31
GBM	chr14	45173096	Silent	NA	S734S	0.28
GBM	chr14	45164500	Missense_Mutation	novel	G575S	0.33
GBM	chr14	45185217	Missense_Mutation	novel	H1506Y	0.14
GBM	chr14	45164495	Missense_Mutation	rs550238354	R573Q	0.31
GBM	chr14	45136048	Missense_Mutation	NA	R6K	0.37
GBM	chr14	45136028	5'UTR	novel		0.11
GBM	chr14	45166995	Missense_Mutation	novel	I612F	0.2
GBM	chr14	45187807	Missense_Mutation	NA	K1567E	0.19
GBM	chr14	45151509	Missense_Mutation	rs754308697	N344I	0.98
GBM	chr14	45136323	Missense_Mutation	novel	I98L	0.09
HNSC	chr14	45164546	Missense_Mutation	novel	S590F	0.33
HNSC	chr14	45136306	Missense_Mutation	novel	R92P	0.21
HNSC	chr14	45189232	Frame_Shift_Ins	novel	*L1738Sfs11**	0.18
HNSC	chr14	45175249	Missense_Mutation	novel	S832C	0.23
HNSC	chr14	45196471	Silent	NA	F1880F	0.19
HNSC	chr14	45189075	Missense_Mutation	novel	E1685Q	0.06
HNSC	chr14	45200022	3'UTR	novel		0.12
HNSC	chr14	45189187	Missense_Mutation	novel	P1722L	0.21
HNSC	chr14	45199945	Silent	rs756119280	Y2028Y	0.29
HNSC	chr14	45198857	Missense_Mutation	novel	L1977S	0.06
HNSC	chr14	45175516	Missense_Mutation	novel	C921F	0.11
HNSC	chr14	45175585	Missense_Mutation	novel	S944C	0.37
HNSC	chr14	45136015	5'UTR	rs376019854		0.53
HNSC	chr14	45170644	Silent	novel	K686K	0.17
HNSC	chr14	45159150	Missense_Mutation	novel	S484L	0.8
KIRC	chr14	45175181	Missense_Mutation	NA	F809L	0.06
KIRC	chr14	45175380	Missense_Mutation	NA	D876H	0.07
KIRC	chr14	45164393	Frame_Shift_Ins	novel	*V541Gfs9**	0.05
KIRC	chr14	45170607	Missense_Mutation	NA	L674P	0.32
KIRP	chr14	45181673	Missense_Mutation	NA	A1452T	0.27
KIRP	chr14	45185247	Missense_Mutation	novel	A1516T	0.41
KIRP	chr14	45175949	Missense_Mutation	NA	C1065W	0.26
KIRP	chr14	45198679	Frame_Shift_Del	novel	*Y1918Mfs5**	0.23
KIRP	chr14	45159279	Missense_Mutation	novel	E527G	0.23
KIRP	chr14	45173136	Missense_Mutation	NA	Q748E	0.61
KIRP	chr14	45135954	5'UTR	novel		0.47
LAML	chr14	45164380	Missense_Mutation	rs757592514	G535S	0.36
LAML	chr14	45196206	Missense_Mutation	novel	G1792V	0.03
LAML	chr14	45137130	Silent	novel	T190T	0.1
LGG	chr14	45175950	Missense_Mutation	novel	L1066V	0.11
LGG	chr14	45153997	Silent	NA	Q376Q	0.3
LGG	chr14	45136149	Missense_Mutation	novel	A40T	0.33
LGG	chr14	45136328	Silent	novel	S99S	0.07
LGG	chr14	45164375	Missense_Mutation	novel	R533H	0.34
LGG	chr14	45176264	Silent	rs749416896	T1170T	0.47
LGG	chr14	45176229	Missense_Mutation	NA	L1159V	0.08
LIHC	chr14	45175853	Silent	novel	K1033K	0.32
LIHC	chr14	45164507	Missense_Mutation	novel	T577I	0.05
LIHC	chr14	45181688	Frame_Shift_Del	novel	*R1457Dfs4**	0.21
LIHC	chr14	45196260	Missense_Mutation	NA	R1810I	0.46
LIHC	chr14	45189277	Missense_Mutation	novel	N1752S	0.36
LIHC	chr14	45148911	Missense_Mutation	novel	L278F	0.86
LIHC	chr14	45189064	Missense_Mutation	NA	N1681I	0.42
LIHC	chr14	45175513	Missense_Mutation	rs776256629	P920L	0.3
LIHC	chr14	45175807	Missense_Mutation	novel	E1018V	0.26
LIHC	chr14	45154713	Silent	NA	K400K	0.34
LIHC	chr14	45181678	Frame_Shift_Ins	novel	*R1456Afs13**	0.29
LIHC	chr14	45166951	Missense_Mutation	novel	I597S	0.04
LIHC	chr14	45188868	Missense_Mutation	novel	G1616S	0.34
LIHC	chr14	45189174	Missense_Mutation	rs371629950	V1718M	0.44
LUAD	chr14	45200075	3'UTR	novel		0.09
LUAD	chr14	45136330	Missense_Mutation	NA	R100L	0.15
LUAD	chr14	45155396	Missense_Mutation	NA	Y445D	0.25
LUAD	chr14	45176499	Missense_Mutation	NA	T1249A	0.19
LUAD	chr14	45189036	Missense_Mutation	NA	D1672N	0.28
LUAD	chr14	45176446	Missense_Mutation	NA	T1231I	0.13
LUAD	chr14	45176964	Missense_Mutation	NA	H1404Y	0.13
LUAD	chr14	45136059	Nonsense_Mutation	NA	Q10*	0.32
LUAD	chr14	45176299	Missense_Mutation	NA	L1182H	0.29
LUAD	chr14	45176817	Missense_Mutation	novel	K1355E	0.05
LUAD	chr14	45136330	Missense_Mutation	NA	R100L	0.28
LUAD	chr14	45175372	Missense_Mutation	novel	G873D	0.2
LUAD	chr14	45140694	Silent	novel	P248P	0.21
LUAD	chr14	45181692	Missense_Mutation	novel	F1458C	0.38
LUAD	chr14	45135974	5'UTR	novel		0.2
LUAD	chr14	45188893	Missense_Mutation	NA	C1624F	0.3
LUAD	chr14	45175713	Silent	novel	L987L	0.13
LUAD	chr14	45185304	Missense_Mutation	novel	E1535Q	0.17
LUAD	chr14	45170670	Frame_Shift_Del	novel	*D696Tfs8**	0.16
LUAD	chr14	45199927	Missense_Mutation	NA	I2022M	0.06
LUAD	chr14	45159122	Missense_Mutation	novel	D475Y	0.21
LUAD	chr14	45164383	Missense_Mutation	novel	G536C	0.16
LUAD	chr14	45159161	Missense_Mutation	NA	S488C	0.59
LUAD	chr14	45176373	Nonsense_Mutation	NA	R1207*	0.23
LUAD	chr14	45151434	Missense_Mutation	novel	N319I	0.21
LUAD	chr14	45187791	Missense_Mutation	novel	M1561I	0.1
LUAD	chr14	45183801	Missense_Mutation	NA	E1472Q	0.17
LUAD	chr14	45176535	Nonsense_Mutation	novel	G1261*	0.14
LUAD	chr14	45189129	Missense_Mutation	rs367653310	H1703Y	0.12
LUAD	chr14	45176507	Silent	rs748733630	D1251D	0.33
LUAD	chr14	45136337	Silent	novel	A102A	0.1
LUAD	chr14	45135974	5'UTR	novel		0.13
LUAD	chr14	45164555	Missense_Mutation	NA	R593P	0.48
LUAD	chr14	45175359	Nonsense_Mutation	NA	E869*	0.1
LUAD	chr14	45176282	Silent	NA	F1176F	0.41
LUAD	chr14	45175129	Nonsense_Mutation	NA	S792*	0.19
LUAD	chr14	45173054	Splice_Site	novel	X721_splice	0.84
LUAD	chr14	45175458	Missense_Mutation	novel	D902H	0.16
LUAD	chr14	45176223	Missense_Mutation	rs374461604	E1157K	0.19
LUAD	chr14	45137137	Missense_Mutation	NA	V193F	0.04	ResIII
LUAD	chr14	45164370	Missense_Mutation	NA	Q531H	0.25
LUAD	chr14	45173131	Missense_Mutation	rs773541028	T746I	0.23
LUAD	chr14	45159251	Missense_Mutation	novel	K518E	0.21
LUAD	chr14	45164566	Splice_Site	novel	X596_splice	0.23
LUAD	chr14	45135954	5'UTR	novel		0.21
LUAD	chr14	45176365	Missense_Mutation	NA	R1204L	0.17
LUSC	chr14	45188850	Missense_Mutation	NA	E1610K	0.23
LUSC	chr14	45175674	Missense_Mutation	novel	D974H	0.51
LUSC	chr14	45151519	Silent	rs140998495	P347P	0.37
LUSC	chr14	45176055	Missense_Mutation	NA	Q1101E	0.4
LUSC	chr14	45198781	Missense_Mutation	NA	E1952K	0.27
LUSC	chr14	45176609	Silent	NA	H1285H	0.18
LUSC	chr14	45153929	Missense_Mutation	novel	Q354K	0.61
LUSC	chr14	45136398	Missense_Mutation	NA	V123L	0.27	ResIII
LUSC	chr14	45188886	Nonsense_Mutation	NA	E1622*	0.4
LUSC	chr14	45154696	Splice_Site	NA	X395_splice	0.61
LUSC	chr14	45159192	Missense_Mutation	novel	Q498L	0.24
LUSC	chr14	45136083	Nonsense_Mutation	novel	R18*	0.43
LUSC	chr14	45185298	Nonsense_Mutation	novel	E1533*	0.24
LUSC	chr14	45173052	Splice_Region	novel		0.07
LUSC	chr14	45198927	Missense_Mutation	NA	M2000I	0.55
LUSC	chr14	45181512	Missense_Mutation	novel	L1435F	0.35
LUSC	chr14	45200006	Nonstop_Mutation	novel	2049Qext20	0.39
LUSC	chr14	45137149	Missense_Mutation	novel	D197H	0.08	ResIII
LUSC	chr14	45176733	Frame_Shift_Del	novel	*F1328Cfs6**	0.39
LUSC	chr14	45196496	Missense_Mutation	novel	S1889R	0.07
LUSC	chr14	45154762	Missense_Mutation	rs141729590	E417Q	0.23
LUSC	chr14	45164485	Missense_Mutation	novel	L570V	0.26
LUSC	chr14	45137179	Nonsense_Mutation	novel	E207*	0.12	ResIII
OV	chr14	45167204	Intron	novel		0.18
OV	chr14	45167206	Intron	novel		0.19
OV	chr14	45189285	Missense_Mutation	novel	E1755K	0.29
OV	chr14	45175373	Silent	NA	G873G	0.29
OV	chr14	45189019	Missense_Mutation	NA	R1666I	0.06
OV	chr14	45176532	Missense_Mutation	NA	Y1260H	0.55
OV	chr14	45176311	Missense_Mutation	NA	N1186T	0.37
OV	chr14	45153933	Missense_Mutation	novel	G355A	0.12
OV	chr14	45189019	Missense_Mutation	NA	R1666I	0.7
OV	chr14	45176334	Missense_Mutation	novel	I1194V	0.16
OV	chr14	45164533	Frame_Shift_Del	NA	*V586Lfs80**	0.98
OV	chr14	45188900	Missense_Mutation	novel	D1626E	0.04
OV	chr14	45175347	Missense_Mutation	rs776830147	Q865E	0.32
PAAD	chr14	45189126	Missense_Mutation	NA	D1702Y	0.19
PAAD	chr14	45136200	Silent	novel	L57L	0.05
PAAD	chr14	45167013	Missense_Mutation	novel	V618L	0.16
PAAD	chr14	45176049	Missense_Mutation	rs767815301	R1099C	0.18
PAAD	chr14	45189358	Missense_Mutation	novel	Q1779P	0.03
PAAD	chr14	45198750	Silent	rs766031579	T1941T	0.18
PCPG	chr14	45181500	Silent	novel	K1431K	0.22
PRAD	chr14	45164399	Missense_Mutation	novel	V541A	0.07
PRAD	chr14	45176189	Silent	rs760913813	D1145D	0.32
PRAD	chr14	45170616	Missense_Mutation	novel	D677V	0.11
PRAD	chr14	45170722	Silent	NA	S712S	0.35
READ	chr14	45167134	Missense_Mutation	rs763495035	R658Q	0.16
READ	chr14	45198719	Missense_Mutation	rs773595869	R1931Q	0.3
READ	chr14	45189250	Missense_Mutation	NA	S1743C	0.26
READ	chr14	45198737	Missense_Mutation	novel	C1937F	0.31
READ	chr14	45148879	Nonsense_Mutation	NA	E268*	0.19
READ	chr14	45175135	Missense_Mutation	NA	F794C	0.06
READ	chr14	45164482	Missense_Mutation	NA	R569C	0.5
READ	chr14	45170692	Missense_Mutation	novel	E702D	0.41
READ	chr14	45175926	Missense_Mutation	novel	N1058H	0.4
READ	chr14	45175309	Missense_Mutation	NA	S852Y	0.36
READ	chr14	45175643	Missense_Mutation	novel	F963L	0.1
READ	chr14	45176034	Missense_Mutation	NA	L1094V	0.39
SARC	chr14	45164519	Missense_Mutation	novel	R581P	0.24
SKCM	chr14	45136290	Missense_Mutation	NA	T87A	0.22
SKCM	chr14	45176406	Missense_Mutation	novel	E1218K	0.27
SKCM	chr14	45164374	Missense_Mutation	rs146151355	R533C	0.43
SKCM	chr14	45176370	Nonsense_Mutation	NA	Q1206*	0.31
SKCM	chr14	45164513	Missense_Mutation	rs754516367	R579H	0.08
SKCM	chr14	45140701	Missense_Mutation	NA	D251Y	0.35
SKCM	chr14	45151415	Missense_Mutation	rs372710600	R313C	0.6
SKCM	chr14	45175371	Missense_Mutation	rs538729337	G873S	0.31
SKCM	chr14	45175372	Missense_Mutation	novel	G873A	0.3
SKCM	chr14	45176331	Nonsense_Mutation	NA	Q1193*	0.13
SKCM	chr14	45164482	Missense_Mutation	NA	R569C	0.25
SKCM	chr14	45167152	Missense_Mutation	NA	S664F	0.2
SKCM	chr14	45148866	Silent	NA	L263L	0.09
SKCM	chr14	45175615	Missense_Mutation	NA	S954F	0.26
SKCM	chr14	45176428	Missense_Mutation	NA	R1225K	0.44
SKCM	chr14	45167199	Intron	novel		0.3
SKCM	chr14	45148992	Silent	NA	I305I	0.29
SKCM	chr14	45175368	Missense_Mutation	NA	H872Y	0.25
SKCM	chr14	45176369	Missense_Mutation	NA	D1205E	0.53
SKCM	chr14	45176575	Missense_Mutation	novel	Y1274C	0.16
SKCM	chr14	45170611	Silent	NA	K675K	0.24
SKCM	chr14	45200038	3'UTR	novel		0.63
SKCM	chr14	45155405	Missense_Mutation	NA	P448S	0.25
SKCM	chr14	45183844	Missense_Mutation	novel	V1486A	0.36
SKCM	chr14	45185336	Silent	novel	F1545F	0.34
SKCM	chr14	45196425	Missense_Mutation	NA	R1865K	0.58
SKCM	chr14	45175405	Missense_Mutation	NA	S884F	0.32
SKCM	chr14	45164374	Missense_Mutation	rs146151355	R533C	0.51
SKCM	chr14	45154815	Silent	novel	I434I	0.21
SKCM	chr14	45176310	In_Frame_Ins	novel	N1186delinsTIVRY	0.07
SKCM	chr14	45167198	Intron	novel		0.31
SKCM	chr14	45176877	Missense_Mutation	novel	E1375K	0.33
SKCM	chr14	45196339	Silent	rs778201887	S1836S	0.46
STAD	chr14	45175297	Missense_Mutation	novel	T848I	0.18
STAD	chr14	45176024	Missense_Mutation	novel	Q1090H	0.21
STAD	chr14	45176040	Missense_Mutation	NA	P1096S	0.08
STAD	chr14	45187806	Missense_Mutation	NA	M1566I	0.23
STAD	chr14	45176680	Missense_Mutation	novel	H1309L	0.27
STAD	chr14	45136161	Missense_Mutation	NA	A44T	0.16
STAD	chr14	45176698	Frame_Shift_Ins	novel	*N1317Kfs2**	0.23
STAD	chr14	45173084	Frame_Shift_Ins	NA	*E735Lfs26**	0.28
STAD	chr14	45137148	Silent	NA	N196N	0.27
STAD	chr14	45148930	Missense_Mutation	NA	K285Q	0.38
STAD	chr14	45176216	Silent	NA	S1154S	0.35
STAD	chr14	45176752	Frame_Shift_Del	rs746983128	*V1336Lfs2**	0.35
STAD	chr14	45196208	Missense_Mutation	novel	A1793T	0.36
STAD	chr14	45199924	Silent	novel	E2021E	0.04
STAD	chr14	45196262	In_Frame_Ins	novel	L1811delinsPQKI	0.05
STAD	chr14	45176190	Missense_Mutation	rs142077813	D1146N	0.06
STAD	chr14	45188937	Missense_Mutation	NA	K1639E	0.07
STAD	chr14	45173161	Missense_Mutation	rs142763060	R756H	0.22
STAD	chr14	45175939	Frame_Shift_Del	rs778191984	*S1064Vfs31**	0.39
STAD	chr14	45176116	Missense_Mutation	novel	S1121N	0.29
STAD	chr14	45181686	Missense_Mutation	rs749332566	R1456H	0.12
STAD	chr14	45176868	Silent	novel	R1372R	0.36
STAD	chr14	45181468	Missense_Mutation	NA	E1421K	0.28
STAD	chr14	45189310	Missense_Mutation	novel	F1763C	0.05
STAD	chr14	45196527	Missense_Mutation	novel	E1899G	0.22
STAD	chr14	45173122	Missense_Mutation	NA	P743H	0.33
STAD	chr14	45159186	Missense_Mutation	NA	L496R	0.26
STAD	chr14	45196456	Silent	novel	V1875V	0.14
STAD	chr14	45200061	3'UTR	novel		0.29
STAD	chr14	45175337	Frame_Shift_Del	novel	*D864Ifs12**	0.32
STAD	chr14	45167061	Missense_Mutation	NA	N634D	0.2
STAD	chr14	45176525	Silent	NA	D1257D	0.14
STAD	chr14	45198843	Silent	NA	A1972A	0.2
STAD	chr14	45198751	Missense_Mutation	rs759078220	A1942T	0.17
STAD	chr14	45176752	Frame_Shift_Del	rs746983128	*V1336Lfs2**	0.45
TGCT	chr14	45148837	Missense_Mutation	novel	A254S	0.14
TGCT	chr14	45196272	Missense_Mutation	novel	E1814V	0.2
THCA	chr14	45200075	3'UTR	novel		0.14
THCA	chr14	45187790	Missense_Mutation	NA	M1561T	0.65
UCEC	chr14	45136411	Missense_Mutation	rs765266610	N127S	0.49	ResIII
UCEC	chr14	45167032	Missense_Mutation	NA	R624I	0.31
UCEC	chr14	45175289	Silent	NA	I845I	0.29
UCEC	chr14	45175643	Silent	rs544323144	F963F	0.29
UCEC	chr14	45175895	Missense_Mutation	NA	Q1047H	0.33
UCEC	chr14	45188973	Nonsense_Mutation	NA	E1651*	0.29
UCEC	chr14	45198792	Missense_Mutation	NA	K1955N	0.26
UCEC	chr14	45200189	3'UTR	novel		0.67
UCEC	chr14	45136488	Missense_Mutation	novel	A153T	0.17	ResIII
UCEC	chr14	45154735	Missense_Mutation	novel	D408Y	0.19
UCEC	chr14	45164474	Missense_Mutation	novel	S566N	0.28
UCEC	chr14	45173205	Missense_Mutation	rs760204880	E771K	0.38
UCEC	chr14	45176039	Silent	novel	V1095V	0.37
UCEC	chr14	45189227	Silent	rs138090463	S1735S	0.32
UCEC	chr14	45175843	Missense_Mutation	NA	R1030Q	0.88
UCEC	chr14	45176614	Missense_Mutation	NA	K1287T	0.39
UCEC	chr14	45151404	Missense_Mutation	rs143006771	E309G	0.18
UCEC	chr14	45175957	Missense_Mutation	novel	D1068G	0.55
UCEC	chr14	45183811	Missense_Mutation	novel	P1475L	0.09
UCEC	chr14	45137132	Missense_Mutation	NA	P191H	0.34	ResIII
UCEC	chr14	45175337	Frame_Shift_Del	novel	*D864Ifs12**	0.46
UCEC	chr14	45196333	Missense_Mutation	NA	I1834M	0.47
UCEC	chr14	45151519	Silent	rs140998495	P347P	0.32
UCEC	chr14	45175870	Missense_Mutation	novel	S1039L	0.34
UCEC	chr14	45151459	Silent	novel	P327P	0.35
UCEC	chr14	45175679	Silent	novel	Q975Q	0.08
UCEC	chr14	45176399	Missense_Mutation	novel	K1215N	0.26
UCEC	chr14	45198707	Missense_Mutation	novel	G1927D	0.38
UCEC	chr14	45136285	Missense_Mutation	NA	Y85C	0.24
UCEC	chr14	45176742	Frame_Shift_Ins	novel	*L1330Sfs15**	0.08
UCEC	chr14	45196450	Nonsense_Mutation	novel	*S1874Afs2**	0.03
UCEC	chr14	45189013	Nonsense_Mutation	novel	*L1664Ffs4**	0.08
UCEC	chr14	45136236	Missense_Mutation	NA	C69R	0.2
UCEC	chr14	45173093	Silent	NA	L733L	0.08
UCEC	chr14	45175881	Frame_Shift_Ins	novel	*V1043Dfs3**	0.29
UCEC	chr14	45181647	Frame_Shift_Ins	novel	*N1443Kfs21**	0.08
UCEC	chr14	45167040	Nonsense_Mutation	rs374626826	R627*	0.21
UCEC	chr14	45173161	Missense_Mutation	rs142763060	R756H	0.22
UCEC	chr14	45176251	Missense_Mutation	NA	A1166V	0.42
UCEC	chr14	45198750	Silent	rs766031579	T1941T	0.38
UCEC	chr14	45176752	Frame_Shift_Del	rs746983128	*V1336Lfs2**	0.4
UCEC	chr14	45136043	Silent	novel	R4R	0.44
UCEC	chr14	45153940	Silent	rs780333012	I357I	0.33
UCEC	chr14	45136194	Missense_Mutation	novel	D55Y	0.36
UCEC	chr14	45175550	Missense_Mutation	novel	K932N	0.3
UCEC	chr14	45175998	Missense_Mutation	novel	D1082Y	0.45
UCEC	chr14	45176388	Nonsense_Mutation	novel	E1212*	0.34
UCEC	chr14	45196254	Missense_Mutation	novel	S1808F	0.31
UCEC	chr14	45136412	Missense_Mutation	novel	N127K	0.08	ResIII
UCEC	chr14	45176842	Missense_Mutation	novel	S1363C	0.38
UCEC	chr14	45175353	Frame_Shift_Del	novel	*E869Kfs7**	0.45
UCEC	chr14	45175336	Frame_Shift_Ins	novel	*D864Rfs4**	0.36
UCEC	chr14	45189088	Missense_Mutation	rs759068569	A1689V	0.38
UCEC	chr14	45176078	Missense_Mutation	novel	Q1108H	0.44
UCEC	chr14	45175729	Missense_Mutation	novel	R992K	0.19
UCEC	chr14	45175902	Nonsense_Mutation	novel	E1050*	0.37
UCEC	chr14	45183834	Missense_Mutation	novel	D1483Y	0.11
UCEC	chr14	45199989	Missense_Mutation	novel	R2043I	0.3
UCEC	chr14	45176423	Silent	rs765751064	C1223C	0.19
UCEC	chr14	45181689	Missense_Mutation	novel	R1457I	0.17
UCEC	chr14	45187811	Missense_Mutation	novel	S1568Y	0.35
UCEC	chr14	45175581	Missense_Mutation	novel	D943Y	0.16
UCEC	chr14	45189075	Nonsense_Mutation	novel	E1685*	0.32
UCEC	chr14	45176752	Frame_Shift_Del	rs746983128	*V1336Lfs2**	0.51
UCEC	chr14	45176752	Frame_Shift_Del	rs746983128	*V1336Lfs2**	0.53
UCEC	chr14	45140641	Nonsense_Mutation	novel	E231*	0.41	ResIII
UCEC	chr14	45154004	Missense_Mutation	novel	M379L	0.22
UCEC	chr14	45198724	Missense_Mutation	novel	L1933I	0.42
UCEC	chr14	45196330	Silent	novel	V1833V	0.28
UCEC	chr14	45175291	Missense_Mutation	novel	K846R	0.5
UCEC	chr14	45176191	Missense_Mutation	novel	D1146V	0.38
UCEC	chr14	45189082	Missense_Mutation	novel	N1687S	0.17
UCEC	chr14	45196399	Silent	rs771670832	I1856I	0.22
UCEC	chr14	45159249	Missense_Mutation	rs149473953	T517M	0.2
UCEC	chr14	45173205	Missense_Mutation	rs760204880	E771K	0.23
UCEC	chr14	45196450	Nonsense_Mutation	novel	*S1874Afs2**	0.07
UCEC	chr14	45196452	Missense_Mutation	novel	S1874N	0.03
UCEC	chr14	45173059	Missense_Mutation	novel	Q722R	0.43
UCEC	chr14	45136048	Missense_Mutation	novel	R6I	0.29
UCEC	chr14	45175332	Nonsense_Mutation	novel	E860*	0.41
UCEC	chr14	45176186	Silent	rs374047969	F1144F	0.38
UCEC	chr14	45176869	Missense_Mutation	novel	R1372I	0.44
UCEC	chr14	45140699	Missense_Mutation	novel	S250I	0.54
UCEC	chr14	45173210	Missense_Mutation	novel	E772D	0.39
UCEC	chr14	45148839	Splice_Region	novel	A254A	0.33
UCEC	chr14	45164374	Missense_Mutation	rs146151355	R533C	0.42
UCEC	chr14	45173104	Missense_Mutation	novel	R737I	0.31
UCEC	chr14	45189355	Missense_Mutation	NA	P1778L	0.32
UCEC	chr14	45199872	Missense_Mutation	NA	S2004L	0.36
UCEC	chr14	45196274	Nonsense_Mutation	novel	G1815*	0.28
UCEC	chr14	45189336	Frame_Shift_Del	NA	C1772*	0.43
UCEC	chr14	45167133	Nonsense_Mutation	rs368728266	R658*	0.35
UCEC	chr14	45175365	Missense_Mutation	NA	N871D	0.2
UCEC	chr14	45175644	Missense_Mutation	rs200017450	E964K	0.26
UCEC	chr14	45175848	Missense_Mutation	NA	D1032Y	0.34
UCEC	chr14	45176341	Missense_Mutation	rs751441742	R1196H	0.17
UCEC	chr14	45196410	Missense_Mutation	rs776506025	R1860H	0.26
UCEC	chr14	45198668	Missense_Mutation	NA	R1914K	0.15
UCEC	chr14	45198738	Silent	NA	C1937C	0.24
UCEC	chr14	45159120	Missense_Mutation	rs532369576	R474H	0.3
UCEC	chr14	45176181	Nonsense_Mutation	novel	E1143*	0.37
UCEC	chr14	45199998	Missense_Mutation	novel	S2046F	0.37
UCEC	chr14	45176770	Missense_Mutation	novel	T1339I	0.2
UCEC	chr14	45176264	Silent	rs749416896	T1170T	0.26
UCEC	chr14	45176774	Silent	novel	P1340P	0.14
UCEC	chr14	45175345	Missense_Mutation	novel	D864G	0.15
UCEC	chr14	45176674	Missense_Mutation	rs61730251	Y1307C	0.33
UCEC	chr14	45176742	Frame_Shift_Ins	novel	*L1330Sfs15**	0.07
UCEC	chr14	45176266	Missense_Mutation	novel	P1171H	0.29
UCEC	chr14	45183891	Missense_Mutation	rs779176062	S1502G	0.23
UCEC	chr14	45196516	Silent	rs746870942	C1895C	0.23
UCEC	chr14	45199887	Missense_Mutation	NA	S2009Y	0.22
UCEC	chr14	45196325	Nonsense_Mutation	NA	E1832*	0.43
UCEC	chr14	45175912	Nonsense_Mutation	NA	S1053*	0.64
UCEC	chr14	45187817	Missense_Mutation	rs201803784	R1570H	0.08
UCEC	chr14	45175615	Missense_Mutation	NA	S954F	0.22
UCEC	chr14	45155390	Missense_Mutation	novel	F443I	0.44
UCEC	chr14	45176375	Missense_Mutation	novel	R1207S	0.08
UCEC	chr14	45175808	Missense_Mutation	rs139432120	E1018D	0.38
UCEC	chr14	45151519	Silent	rs140998495	P347P	0.23
UCEC	chr14	45164507	Missense_Mutation	novel	T577N	0.22
UCEC	chr14	45173095	Missense_Mutation	novel	S734F	0.22
UCEC	chr14	45175751	Silent	rs141430587	P999P	0.35
UCEC	chr14	45176518	Missense_Mutation	novel	P1255H	0.42
UCEC	chr14	45176774	Silent	novel	P1340P	0.17
UCEC	chr14	45198822	Silent	novel	V1965V	0.37
UCEC	chr14	45167090	Silent	novel	T643T	0.46
UCEC	chr14	45159280	Missense_Mutation	NA	E527D	0.24
UCEC	chr14	45136308	Missense_Mutation	novel	D93N	0.48
UCEC	chr14	45151459	Silent	novel	P327P	0.34
UCEC	chr14	45155426	Nonsense_Mutation	novel	E455*	0.47
UCEC	chr14	45164394	Silent	novel	T539T	0.48
UCEC	chr14	45137242	Splice_Site	novel	X227_splice	0.26
UCEC	chr14	45175826	Silent	NA	P1024P	0.4
UCEC	chr14	45185333	Frame_Shift_Ins	novel	*L1546Ffs3**	0.28
UCEC	chr14	45198776	Missense_Mutation	rs559661870	L1950S	0.38
UCS	chr14	45166959	Missense_Mutation	novel	Q600K	0.25
UCS	chr14	45154007	Silent	novel	R380R	0.82
UCS	chr14	45155426	Missense_Mutation	novel	E455K	0.49
UCS	chr14	45164374	Missense_Mutation	rs146151355	R533C	0.4
UCS	chr14	45173198	Missense_Mutation	novel	M768I	0.1
UCS	chr14	45196433	Missense_Mutation	novel	Q1868E	0.1
UVM	chr14	45198808	Missense_Mutation	novel	V1961F	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1556	0.19769
CHOL	DEL	0.3611	0.00040262
KIRP	DEL	0.1667	0.085174
PAAD	DEL	0.0598	0.11332

Survival Analysis

Cancer	P-value	Q-value
THYM	0.016	Kaplan-Meier Survival Analysis
KIRC	0.0072	Kaplan-Meier Survival Analysis
SARC	0.014	Kaplan-Meier Survival Analysis
ACC	0.00016	Kaplan-Meier Survival Analysis
SKCM	0.041	Kaplan-Meier Survival Analysis
PRAD	0.012	Kaplan-Meier Survival Analysis
LUSC	0.044	Kaplan-Meier Survival Analysis
ESCA	0.041	Kaplan-Meier Survival Analysis
PCPG	0.01	Kaplan-Meier Survival Analysis
KICH	0.026	Kaplan-Meier Survival Analysis
LIHC	0.038	Kaplan-Meier Survival Analysis
LGG	0.027	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000187790 (Gene tree)
Gene ID: 57697
Gene Symbol: FANCM
Alias: FAAP250|KIAA1596
Full Name: FA complementation group M
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 64,958 bases
Position: chr14:45,135,933-45,200,890
Accession: 23168
RBP type: canonical RBP
Summary: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000450596	ResIII	PF04851.15	2.4e-18	1	1
ENSP00000267430	ResIII	PF04851.15	9.4e-17	1	1
ENSP00000442493	ResIII	PF04851.15	9.2e-13	1	1
ENSP00000450596	DEAD	PF00270.29	1.4e-17	1	1
ENSP00000267430	DEAD	PF00270.29	7.8e-17	1	1
ENSP00000442493	DEAD	PF00270.29	2.9e-14	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000556250	FANCM-209	5577	XM_011537037	ENSP00000452033	1564 (aa)	XP_011535339	H0YJS3
ENST00000553551	FANCM-203	603	-	-	- (aa)	-	-
ENST00000542564	FANCM-202	6167	XM_011537035	ENSP00000442493	2022 (aa)	XP_011535337	Q8IYD8
ENST00000267430	FANCM-201	7111	XM_011537034	ENSP00000267430	2048 (aa)	XP_011535336	Q8IYD8
ENST00000554809	FANCM-205	3112	-	ENSP00000450632	1016 (aa)	-	H0YJ14
ENST00000557110	FANCM-210	638	-	ENSP00000451846	135 (aa)	-	H0YJN7
ENST00000554030	FANCM-204	917	-	-	- (aa)	-	-
ENST00000555013	FANCM-206	573	-	-	- (aa)	-	-
ENST00000555484	FANCM-207	448	-	ENSP00000450797	106 (aa)	-	H0YJ45
ENST00000556036	FANCM-208	2354	-	ENSP00000450596	669 (aa)	-	Q8IYD8

Gene Model

Click here to download ENSG00000187790's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03460	Fanconi anemia pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000187790	Platelet Function Tests	1.9154700E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000187790's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000187790	FANCM	55	55.035	ENSAPOG00000014274	-	96	55.035	Acanthochromis_polyacanthus
ENSG00000187790	FANCM	99	90.462	ENSAMEG00000002114	FANCM	99	79.825	Ailuropoda_melanoleuca
ENSG00000187790	FANCM	97	64.977	ENSACIG00000005444	-	96	64.688	Amphilophus_citrinellus
ENSG00000187790	FANCM	96	58.873	ENSATEG00000012412	-	77	54.734	Anabas_testudineus
ENSG00000187790	FANCM	99	95.359	ENSANAG00000025075	FANCM	99	91.752	Aotus_nancymaae
ENSG00000187790	FANCM	97	58.520	ENSACLG00000016008	-	70	54.566	Astatotilapia_calliptera
ENSG00000187790	FANCM	97	58.832	ENSAMXG00000020275	-	89	54.142	Astyanax_mexicanus
ENSG00000187790	FANCM	99	89.021	ENSBTAG00000002612	FANCM	95	89.888	Bos_taurus
ENSG00000187790	FANCM	99	95.060	ENSCJAG00000015945	FANCM	99	90.386	Callithrix_jacchus
ENSG00000187790	FANCM	99	89.671	ENSCAFG00000014062	FANCM	99	79.309	Canis_familiaris
ENSG00000187790	FANCM	100	89.088	ENSCAFG00020022069	-	100	89.088	Canis_lupus_dingo
ENSG00000187790	FANCM	99	88.427	ENSCHIG00000015176	FANCM	99	75.948	Capra_hircus
ENSG00000187790	FANCM	88	93.581	ENSTSYG00000036497	-	88	93.581	Carlito_syrichta
ENSG00000187790	FANCM	100	84.604	ENSCPOG00000001446	FANCM	99	71.373	Cavia_porcellus
ENSG00000187790	FANCM	99	95.509	ENSCCAG00000026593	FANCM	99	83.650	Cebus_capucinus
ENSG00000187790	FANCM	99	97.156	ENSCATG00000031379	FANCM	99	94.632	Cercocebus_atys
ENSG00000187790	FANCM	99	97.754	ENSCSAG00000015308	FANCM	99	94.924	Chlorocebus_sabaeus
ENSG00000187790	FANCM	89	92.553	ENSCHOG00000000190	FANCM	81	85.799	Choloepus_hoffmanni
ENSG00000187790	FANCM	99	72.100	ENSCPBG00000015089	FANCM	100	50.327	Chrysemys_picta_bellii
ENSG00000187790	FANCM	99	97.754	ENSCANG00000029498	FANCM	99	94.046	Colobus_angolensis_palliatus
ENSG00000187790	FANCM	99	84.871	ENSCGRG00001023573	Fancm	99	65.938	Cricetulus_griseus_chok1gshd
ENSG00000187790	FANCM	97	58.403	ENSCSEG00000002313	-	73	52.626	Cynoglossus_semilaevis
ENSG00000187790	FANCM	86	65.972	ENSCVAG00000015579	-	68	60.494	Cyprinodon_variegatus
ENSG00000187790	FANCM	99	88.244	ENSDNOG00000007697	FANCM	99	76.246	Dasypus_novemcinctus
ENSG00000187790	FANCM	98	83.891	ENSDORG00000010095	Fancm	99	67.591	Dipodomys_ordii
ENSG00000187790	FANCM	82	85.500	ENSETEG00000003360	FANCM	81	84.091	Echinops_telfairi
ENSG00000187790	FANCM	99	86.140	ENSEASG00005007781	FANCM	99	85.606	Equus_asinus_asinus
ENSG00000187790	FANCM	99	86.438	ENSECAG00000018694	FANCM	87	76.591	Equus_caballus
ENSG00000187790	FANCM	88	78.571	ENSEEUG00000005607	-	90	75.510	Erinaceus_europaeus
ENSG00000187790	FANCM	91	64.204	ENSELUG00000015761	-	72	59.921	Esox_lucius
ENSG00000187790	FANCM	100	89.583	ENSFCAG00000022146	-	99	89.717	Felis_catus
ENSG00000187790	FANCM	89	67.608	ENSFALG00000001703	FANCM	78	64.335	Ficedula_albicollis
ENSG00000187790	FANCM	99	87.145	ENSFDAG00000009043	FANCM	99	72.736	Fukomys_damarensis
ENSG00000187790	FANCM	82	72.868	ENSFHEG00000006371	-	90	71.111	Fundulus_heteroclitus
ENSG00000187790	FANCM	96	62.346	ENSGMOG00000002019	-	75	56.159	Gadus_morhua
ENSG00000187790	FANCM	87	72.483	ENSGALG00000031182	FANCM	91	54.329	Gallus_gallus
ENSG00000187790	FANCM	96	60.823	ENSGACG00000009448	-	81	48.148	Gasterosteus_aculeatus
ENSG00000187790	FANCM	52	62.117	ENSGAGG00000007068	-	93	63.989	Gopherus_agassizii
ENSG00000187790	FANCM	100	98.730	ENSGGOG00000008546	FANCM	100	98.730	Gorilla_gorilla
ENSG00000187790	FANCM	97	58.380	ENSHBUG00000007085	-	84	54.452	Haplochromis_burtoni
ENSG00000187790	FANCM	90	97.895	ENSHGLG00000013787	FANCM	99	74.951	Heterocephalus_glaber_female
ENSG00000187790	FANCM	90	97.895	ENSHGLG00100006377	FANCM	99	74.903	Heterocephalus_glaber_male
ENSG00000187790	FANCM	97	61.256	ENSHCOG00000013769	-	97	60.811	Hippocampus_comes
ENSG00000187790	FANCM	98	57.969	ENSIPUG00000014629	fancm	88	56.742	Ictalurus_punctatus
ENSG00000187790	FANCM	52	56.174	ENSKMAG00000009391	-	99	56.174	Kryptolebias_marmoratus
ENSG00000187790	FANCM	97	58.956	ENSLBEG00000004982	-	69	55.569	Labrus_bergylta
ENSG00000187790	FANCM	99	69.507	ENSLACG00000007739	FANCM	99	46.516	Latimeria_chalumnae
ENSG00000187790	FANCM	99	64.758	ENSLOCG00000011318	FANCM	91	58.480	Lepisosteus_oculatus
ENSG00000187790	FANCM	99	87.073	ENSLAFG00000001136	FANCM	100	77.024	Loxodonta_africana
ENSG00000187790	FANCM	99	97.305	ENSMFAG00000000383	FANCM	99	94.632	Macaca_fascicularis
ENSG00000187790	FANCM	99	97.305	ENSMMUG00000016513	FANCM	99	94.583	Macaca_mulatta
ENSG00000187790	FANCM	99	97.305	ENSMNEG00000038659	FANCM	99	94.680	Macaca_nemestrina
ENSG00000187790	FANCM	97	93.939	ENSMLEG00000035743	FANCM	99	93.750	Mandrillus_leucophaeus
ENSG00000187790	FANCM	97	58.832	ENSMAMG00000007087	-	77	55.774	Mastacembelus_armatus
ENSG00000187790	FANCM	97	58.520	ENSMZEG00005004644	-	70	54.566	Maylandia_zebra
ENSG00000187790	FANCM	99	77.610	ENSMAUG00000015450	Fancm	99	62.938	Mesocricetus_auratus
ENSG00000187790	FANCM	99	91.467	ENSMICG00000005811	FANCM	99	82.708	Microcebus_murinus
ENSG00000187790	FANCM	99	81.392	ENSMOCG00000008775	Fancm	99	62.458	Microtus_ochrogaster
ENSG00000187790	FANCM	87	63.481	ENSMMOG00000010215	-	68	59.178	Mola_mola
ENSG00000187790	FANCM	98	75.187	ENSMODG00000007334	FANCM	98	55.469	Monodelphis_domestica
ENSG00000187790	FANCM	52	55.610	ENSMALG00000013187	-	94	55.610	Monopterus_albus
ENSG00000187790	FANCM	99	82.934	MGP_CAROLIEiJ_G0017791	Fancm	99	64.286	Mus_caroli
ENSG00000187790	FANCM	99	82.335	ENSMUSG00000055884	Fancm	98	82.335	Mus_musculus
ENSG00000187790	FANCM	99	78.838	MGP_PahariEiJ_G0029547	Fancm	99	63.387	Mus_pahari
ENSG00000187790	FANCM	99	82.335	MGP_SPRETEiJ_G0018636	Fancm	99	64.303	Mus_spretus
ENSG00000187790	FANCM	99	90.611	ENSMPUG00000004849	FANCM	99	78.184	Mustela_putorius_furo
ENSG00000187790	FANCM	99	86.607	ENSMLUG00000006671	FANCM	100	77.279	Myotis_lucifugus
ENSG00000187790	FANCM	99	82.934	ENSNGAG00000017199	Fancm	99	69.238	Nannospalax_galili
ENSG00000187790	FANCM	99	98.653	ENSNLEG00000004432	FANCM	99	96.096	Nomascus_leucogenys
ENSG00000187790	FANCM	90	72.632	ENSMEUG00000004977	-	67	73.729	Notamacropus_eugenii
ENSG00000187790	FANCM	97	64.427	ENSONIG00000003531	-	95	51.691	Oreochromis_niloticus
ENSG00000187790	FANCM	90	78.947	ENSOANG00000013997	FANCM	99	53.166	Ornithorhynchus_anatinus
ENSG00000187790	FANCM	99	90.719	ENSOCUG00000007539	FANCM	99	77.257	Oryctolagus_cuniculus
ENSG00000187790	FANCM	97	58.873	ENSORLG00020013516	-	73	54.798	Oryzias_latipes_hni
ENSG00000187790	FANCM	97	58.815	ENSORLG00015012100	-	73	54.630	Oryzias_latipes_hsok
ENSG00000187790	FANCM	97	60.545	ENSOMEG00000010717	-	75	56.280	Oryzias_melastigma
ENSG00000187790	FANCM	98	90.137	ENSOGAG00000003015	FANCM	100	77.178	Otolemur_garnettii
ENSG00000187790	FANCM	99	88.576	ENSOARG00000009429	FANCM	99	76.142	Ovis_aries
ENSG00000187790	FANCM	100	98.926	ENSPPAG00000028944	FANCM	100	98.926	Pan_paniscus
ENSG00000187790	FANCM	100	88.988	ENSPPRG00000011952	-	99	89.121	Panthera_pardus
ENSG00000187790	FANCM	100	88.839	ENSPTIG00000018621	-	99	88.972	Panthera_tigris_altaica
ENSG00000187790	FANCM	100	98.863	ENSPTRG00000006307	FANCM	100	98.863	Pan_troglodytes
ENSG00000187790	FANCM	99	97.605	ENSPANG00000023200	FANCM	99	94.632	Papio_anubis
ENSG00000187790	FANCM	52	59.398	ENSPKIG00000000861	-	92	59.148	Paramormyrops_kingsleyae
ENSG00000187790	FANCM	99	83.735	ENSPEMG00000005619	Fancm	99	64.210	Peromyscus_maniculatus_bairdii
ENSG00000187790	FANCM	100	74.891	ENSPCIG00000005354	-	99	75.036	Phascolarctos_cinereus
ENSG00000187790	FANCM	97	62.481	ENSPFOG00000002008	-	77	63.333	Poecilia_formosa
ENSG00000187790	FANCM	97	59.944	ENSPLAG00000014164	-	76	56.083	Poecilia_latipinna
ENSG00000187790	FANCM	97	59.212	ENSPMEG00000010746	-	76	55.954	Poecilia_mexicana
ENSG00000187790	FANCM	97	59.379	ENSPREG00000019849	-	83	55.504	Poecilia_reticulata
ENSG00000187790	FANCM	99	98.204	ENSPPYG00000005781	FANCM	99	97.387	Pongo_abelii
ENSG00000187790	FANCM	90	85.263	ENSPCAG00000011363	-	64	84.127	Procavia_capensis
ENSG00000187790	FANCM	90	92.632	ENSPCOG00000014388	FANCM	99	81.647	Propithecus_coquereli
ENSG00000187790	FANCM	88	90.043	ENSPVAG00000015802	FANCM	71	90.043	Pteropus_vampyrus
ENSG00000187790	FANCM	97	54.597	ENSPNAG00000013558	-	80	50.408	Pygocentrus_nattereri
ENSG00000187790	FANCM	99	81.764	ENSRNOG00000056721	Fancm	100	71.914	Rattus_norvegicus
ENSG00000187790	FANCM	99	95.970	ENSRBIG00000011451	FANCM	99	93.857	Rhinopithecus_bieti
ENSG00000187790	FANCM	99	97.305	ENSRROG00000028917	FANCM	99	94.632	Rhinopithecus_roxellana
ENSG00000187790	FANCM	85	31.220	YIR002C	-	60	31.270	Saccharomyces_cerevisiae
ENSG00000187790	FANCM	99	95.060	ENSSBOG00000030882	FANCM	99	90.874	Saimiri_boliviensis_boliviensis
ENSG00000187790	FANCM	99	73.977	ENSSHAG00000000507	FANCM	100	54.531	Sarcophilus_harrisii
ENSG00000187790	FANCM	96	58.449	ENSSMAG00000019903	-	99	55.990	Scophthalmus_maximus
ENSG00000187790	FANCM	96	62.481	ENSSDUG00000016682	-	95	62.519	Seriola_dumerili
ENSG00000187790	FANCM	96	59.212	ENSSLDG00000003408	-	77	48.749	Seriola_lalandi_dorsalis
ENSG00000187790	FANCM	89	84.783	ENSSARG00000002618	FANCM	82	84.950	Sorex_araneus
ENSG00000187790	FANCM	99	87.592	ENSSSCG00000005000	FANCM	99	77.762	Sus_scrofa
ENSG00000187790	FANCM	89	70.957	ENSTGUG00000013226	-	100	68.501	Taeniopygia_guttata
ENSG00000187790	FANCM	96	62.597	ENSTRUG00000009756	-	95	62.328	Takifugu_rubripes
ENSG00000187790	FANCM	98	63.459	ENSTNIG00000017277	-	100	39.401	Tetraodon_nigroviridis
ENSG00000187790	FANCM	99	89.072	ENSTTRG00000006669	FANCM	99	79.737	Tursiops_truncatus
ENSG00000187790	FANCM	99	89.104	ENSUMAG00000007704	-	97	89.104	Ursus_maritimus
ENSG00000187790	FANCM	90	96.842	ENSVPAG00000005763	FANCM	73	90.571	Vicugna_pacos
ENSG00000187790	FANCM	99	89.222	ENSVVUG00000000357	FANCM	99	79.346	Vulpes_vulpes
ENSG00000187790	FANCM	70	68.590	ENSXETG00000003046	fancm	100	68.710	Xenopus_tropicalis
ENSG00000187790	FANCM	98	59.384	ENSXMAG00000007702	-	76	55.000	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000712	resolution of meiotic recombination intermediates	20347428.	IMP	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003682	chromatin binding	20347429.	IDA	Function
GO:0004518	nuclease activity	-	IEA	Function
GO:0005515	protein binding	17289582.20347429.25416956.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0031297	replication fork processing	20347428.	IMP	Process
GO:0032508	DNA duplex unwinding	-	IEA	Process
GO:0036297	interstrand cross-link repair	-	TAS	Process
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	-	IEA	Function
GO:0043240	Fanconi anaemia nuclear complex	20347428.20347429.	IDA	Component
GO:0071821	FANCM-MHF complex	20347428.	IDA	Component
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process
GO:1902527	positive regulation of protein monoubiquitination	29231814.	IMP	Process

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