EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28592131	Phosphorylated 4E-BP1 is associated with tumor progression and adverse prognosis in colorectal cancer.	Neoplasma	2017	Chen Y	doi: 10.4149/neo_2017_518.
18708753	Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival.	Cancer Biol Ther	2008 Sep	Barnhart BC	-
17601486	Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells.	Arch Biochem Biophys	2007 Sep 1	Peffley DM	-
24837366	The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner.	Oncogene	2015 Mar 26	Im YK	doi: 10.1038/onc.2014.110
24466059	eRF3b, a biomarker for hepatocellular carcinoma, influences cell cycle and phosphoralation status of 4E-BP1.	PLoS One	2014 Jan 23	Li M	doi: 10.1371/journal.pone.0086371
26829052	Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis.	Oncogene	2016 Sep 8	Musa J	doi: 10.1038/onc.2015.515
26942880	4EGI-1 induces apoptosis and enhances radiotherapy sensitivity in nasopharyngeal carcinoma cells via DR5 induction on 4E-BP1 dephosphorylation.	Oncotarget	2016 Apr 19	Wang W	doi: 10.18632/oncotarget.7824.
28242042	Eukaryotic translation initiation factor 4E (eIF-4E) expressions are associated with poor prognosis in colorectal adenocarcinoma.	Pathol Res Pract	2017 May	Chen YT	doi: 10.1016/j.prp.2017.02.004
21750861	The effect of p-4E-BP1 and p-eIF4E on cell proliferation in a breast cancer model.	Int J Oncol	2011 Nov	Pons B	doi: 10.3892/ijo.2011.1118
25618298	Significance of 4E-binding protein 1 as a therapeutic target for invasive urothelial carcinoma of the bladder.	Urol Oncol	2015 Apr	Nishikawa M	doi: 10.1016/j.urolonc.2014.12.006
26646586	MicroRNAs 125a and 125b inhibit ovarian cancer cells through post-transcriptional inactivation of EIF4EBP1.	Oncotarget	2016 Feb 23	Lee M	doi: 10.18632/oncotarget.6474.
26204490	eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer.	Oncotarget	2015 Sep 15	Chao MW	-
24131622	The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials.	Breast Cancer Res	2013	Karlsson E	-
25114899	Sensitization of cancer cells through reduction of total Akt and downregulation of salinomycin-induced pAkt, pGSk3β, pTSC2, and p4EBP1 by cotreatment with MK-2206.	Biomed Res Int	2014	Choi AR	doi: 10.1155/2014/295760
25659153	Tanshinone IIA inhibits HIF-1α and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway.	PLoS One	2015 Feb 6	Li G	doi: 10.1371/journal.pone.0117440
23640516	Aerosol delivery of eukaryotic translation initiation factor 4E-binding protein 1 effectively suppresses lung tumorigenesis in K-rasLA1 mice.	Cancer Gene Ther	2013 Jun	Chang SH	doi: 10.1038/cgt.2013.24
16648488	Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells.	Mol Cell Biol	2006 May	Connolly E	-
22110663	S6K1 and 4E-BP1 are independent regulated and control cellular growth in bladder cancer.	PLoS One	2011	Nawroth R	doi: 10.1371/journal.pone.0027509
26097581	Prognostic significance of phosphorylated 4E-binding protein 1 in non-small cell lung cancer.	Int J Clin Exp Pathol	2015 Apr 1	Lee HW	-
19367274	Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity.	Br J Cancer	2009 May 5	Coleman LJ	doi: 10.1038/sj.bjc.6605044
23340172	Phosphorylation of 4E-BP1 predicts sensitivity to everolimus in gastric cancer cells.	Cancer Lett	2013 May 1	Nishi T	doi: 10.1016/j.canlet.2013.01.004
16652388	Expression of mTOR signaling pathway markers in prostate cancer progression.	Prostate	2006 Aug 1	Kremer CL	-
21922152	Association between LRRK2 and 4E-BP1 protein levels in normal and malignant cells.	Oncol Rep	2012 Jan	Pons B	doi: 10.3892/or.2011.1462
26577921	Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors.	Sci Signal	2015 Nov 17	Hsieh AC	doi: 10.1126/scisignal.aad5111.
25661069	Overexpression of phosphorylated 4E-binding protein 1 and its clinicopathological significances in gastric cancer.	Pathol Res Pract	2015 Apr	Lee HW	doi: 10.1016/j.prp.2014.12.015
28339030	Increased phosphorylation of 4Ebinding protein 1 predicts poor prognosis for patients with colorectal cancer.	Mol Med Rep	2017 May	Miao Y	doi: 10.3892/mmr.2017.6352
28427795	Reappraisal to the study of 4E-BP1 as an mTOR substrate - A normative critique.	Eur J Cell Biol	2017 Jun	Batool A	doi: 10.1016/j.ejcb.2017.03.013

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr8	38057192	Missense_Mutation	NA	S86N	0.28	eIF_4EBP
BLCA	chr8	38059984	3'UTR	rs770459886		0.12
GBM	chr8	38057082	Splice_Region	novel	G49G	0.29
GBM	chr8	38057084	Missense_Mutation	novel	T50I	0.06	eIF_4EBP
HNSC	chr8	38057260	Missense_Mutation	novel	G109C	0.19	eIF_4EBP
HNSC	chr8	38057136	Silent	NA	V67V	0.21
LUSC	chr8	38057091	Silent	NA	I52I	0.51
LUSC	chr8	38057112	Silent	novel	L59L	0.08
OV	chr8	38057226	Missense_Mutation	NA	H97Q	0.35	eIF_4EBP
SKCM	chr8	38057102	Missense_Mutation	rs767454211	R56Q	0.4	eIF_4EBP
STAD	chr8	38060021	3'UTR	novel		0.27
STAD	chr8	38060031	3'UTR	novel		0.09
STAD	chr8	38057255	Missense_Mutation	rs751889248	A107V	0.22	eIF_4EBP
UCEC	chr8	38057158	Missense_Mutation	novel	L75M	0.39	eIF_4EBP
UCEC	chr8	38059998	3'UTR	novel		0.39
UCEC	chr8	38059960	3'UTR	novel		0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	DEL	0.2554	0.060925
PAAD	AMP	0.087	0.021017
PRAD	AMP	0.1118	0.00020824
READ	DEL	0.2788	0.20625
SARC	AMP	0.2296	0.16281

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0043	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00017	Kaplan-Meier Survival Analysis
UCS	0.025	Kaplan-Meier Survival Analysis
SKCM	0.034	Kaplan-Meier Survival Analysis
LUSC	0.012	Kaplan-Meier Survival Analysis
KIRP	0.0014	Kaplan-Meier Survival Analysis
PAAD	0.00051	Kaplan-Meier Survival Analysis
BLCA	0.0048	Kaplan-Meier Survival Analysis
READ	0.046	Kaplan-Meier Survival Analysis
LAML	0.0038	Kaplan-Meier Survival Analysis
KICH	0.038	Kaplan-Meier Survival Analysis
UCEC	0.008	Kaplan-Meier Survival Analysis
LIHC	0.00046	Kaplan-Meier Survival Analysis
DLBC	0.01	Kaplan-Meier Survival Analysis
LUAD	0.012	Kaplan-Meier Survival Analysis
OV	0.019	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000187840 (Gene tree)
Gene ID: 1978
Gene Symbol: EIF4EBP1
Alias: PHAS-I|4E-BP1
Full Name: eukaryotic translation initiation factor 4E binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 30,025 bases
Position: chr8:38,030,341-38,060,365
Accession: 3288
RBP type: canonical RBP
Summary: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000340691	eIF_4EBP	PF05456.11	2.2e-43	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15860463	Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice.	J Gerontol A Biol Sci Med Sci	2005 Mar	Sharp ZD	-
17255101	p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells.	J Biol Chem	2007 Apr 20	Ishida H	-
30209975	Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.	Autophagy	2019 Jan	Yau WW	doi: 10.1080/15548627.2018.1511263
11723111	Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.	J Biol Chem	2002 Feb 1	Scheper GC	-
16049009	hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase.	J Biol Chem	2005 Sep 23	Byfield MP	-
19112551	Attenuation of skeletal muscle atrophy in cancer cachexia by D-myo-inositol 1,2,6-triphosphate.	Cancer Chemother Pharmacol	2009 Aug	Russell ST	doi: 10.1007/s00280-008-0899-z
17510057	PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.	J Biol Chem	2007 Jul 6	Wang L	-
20876744	Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer.	Mol Cancer Ther	2010 Oct	Luyimbazi D	doi: 10.1158/1535-7163.MCT-09-0980
24135021	Role of IkB kinase-β in the growth-promoting effects of angiotensin II in vitro and in vivo.	Arterioscler Thromb Vasc Biol	2013 Dec	Doyon P	doi: 10.1161/ATVBAHA.113.302487
1382053	The 10 S BC-1 ribonucleoprotein particle contains identifier sequence-binding proteins that interact with an array of GCAAG/CTTGC motifs between split promoter sequences for RNA polymerase III.	J Biol Chem	1992 Sep 15	Kobayashi S	-
16339025	Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.	J Neurosci	2005 Dec 7	Jaworski J	-
16179492	Prolonged submaximal exercise induces isoform-specific Na+-K+-ATPase mRNA and protein responses in human skeletal muscle.	Am J Physiol Regul Integr Comp Physiol	2006 Feb	Murphy KT	-
18842593	Rheb and mTOR regulate neuronal polarity through Rap1B.	J Biol Chem	2008 Nov 28	Li YH	doi: 10.1074/jbc.M802431200
22647292	Mechanisms of protein degradation in mantle muscle and proposed gill remodeling in starved Sepia officinalis.	Am J Physiol Regul Integr Comp Physiol	2012 Aug 15	Lamarre SG	doi: 10.1152/ajpregu.00077.2012
21366462	Expression and phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 in B-cell lymphomas and reactive lymphoid tissues.	Arch Pathol Lab Med	2011 Mar	Kodali D	doi: 10.1043/2009-0759-OA.1.
20304964	The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin.	Am J Pathol	2010 May	Block K	doi: 10.2353/ajpath.2010.090606
28539821	Stabilization of 4E-BP1 by PI3K kinase and its involvement in CHK2 phosphorylation in the cellular response to radiation.	Int J Med Sci	2017 Apr 9	Yu ZJ	doi: 10.7150/ijms.18329
30488423	Protective effect of microRNA-224 on acute lower extremity ischemia through activation of the mTOR signaling pathway via CHOP in mice.	J Cell Physiol	2019 Jun	Chen YX	doi: 10.1002/jcp.27550
30819820	CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.	Genes Dev	2019 Apr 1	Choi SH	doi: 10.1101/gad.322339.118

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000520657	EIF4EBP1-202	695	-	-	- (aa)	-	-
ENST00000338825	EIF4EBP1-201	1020	-	ENSP00000340691	118 (aa)	-	Q13541

Gene Model

Click here to download ENSG00000187840's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa01521	EGFR tyrosine kinase inhibitor resistance	KEGG
hsa03013	RNA transport	KEGG
hsa04012	ErbB signaling pathway	KEGG
hsa04066	HIF-1 signaling pathway	KEGG
hsa04150	mTOR signaling pathway	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04152	AMPK signaling pathway	KEGG
hsa04211	Longevity regulating pathway	KEGG
hsa04218	Cellular senescence	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05165	Human papillomavirus infection	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG
hsa05221	Acute myeloid leukemia	KEGG
hsa05231	Choline metabolism in cancer	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000187840	rs28807105	8	38035999	G	Menopause (age at onset)	29773799	[0.1-0.22] year increase	0.16	EFO_0004704

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000187840's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000187840	EIF4EBP1	97	57.983	ENSAPOG00000008772	-	98	57.983	Acanthochromis_polyacanthus
ENSG00000187840	EIF4EBP1	100	56.452	ENSAPOG00000019728	eif4ebp1	100	56.452	Acanthochromis_polyacanthus
ENSG00000187840	EIF4EBP1	100	93.220	ENSAMEG00000011071	EIF4EBP1	98	93.220	Ailuropoda_melanoleuca
ENSG00000187840	EIF4EBP1	97	54.701	ENSACIG00000010565	-	98	54.701	Amphilophus_citrinellus
ENSG00000187840	EIF4EBP1	100	53.968	ENSACIG00000008686	eif4ebp1	100	55.906	Amphilophus_citrinellus
ENSG00000187840	EIF4EBP1	97	61.739	ENSAOCG00000001279	eif4ebp1	97	61.739	Amphiprion_ocellaris
ENSG00000187840	EIF4EBP1	97	57.143	ENSAOCG00000023739	-	98	57.143	Amphiprion_ocellaris
ENSG00000187840	EIF4EBP1	97	61.739	ENSAPEG00000002059	eif4ebp1	97	61.739	Amphiprion_percula
ENSG00000187840	EIF4EBP1	97	57.143	ENSAPEG00000024358	-	98	57.143	Amphiprion_percula
ENSG00000187840	EIF4EBP1	100	53.226	ENSATEG00000021479	eif4ebp1	100	53.226	Anabas_testudineus
ENSG00000187840	EIF4EBP1	97	57.627	ENSATEG00000010916	-	98	57.627	Anabas_testudineus
ENSG00000187840	EIF4EBP1	62	65.753	ENSAPLG00000015855	EIF4EBP1	100	65.753	Anas_platyrhynchos
ENSG00000187840	EIF4EBP1	100	63.559	ENSACAG00000028558	EIF4EBP1	100	63.559	Anolis_carolinensis
ENSG00000187840	EIF4EBP1	100	67.227	ENSANAG00000037550	-	100	67.227	Aotus_nancymaae
ENSG00000187840	EIF4EBP1	100	97.458	ENSANAG00000028425	-	100	97.458	Aotus_nancymaae
ENSG00000187840	EIF4EBP1	97	53.846	ENSACLG00000025025	-	98	53.846	Astatotilapia_calliptera
ENSG00000187840	EIF4EBP1	97	53.846	ENSACLG00000016553	-	98	53.846	Astatotilapia_calliptera
ENSG00000187840	EIF4EBP1	100	56.911	ENSACLG00000023638	eif4ebp1	100	56.911	Astatotilapia_calliptera
ENSG00000187840	EIF4EBP1	96	61.739	ENSAMXG00000033622	eif4ebp1	97	61.739	Astyanax_mexicanus
ENSG00000187840	EIF4EBP1	100	92.373	ENSBTAG00000027654	EIF4EBP1	100	92.373	Bos_taurus
ENSG00000187840	EIF4EBP1	100	95.763	ENSCJAG00000002671	EIF4EBP1	100	95.763	Callithrix_jacchus
ENSG00000187840	EIF4EBP1	100	94.915	ENSCAFG00000006154	EIF4EBP1	100	94.915	Canis_familiaris
ENSG00000187840	EIF4EBP1	100	94.915	ENSCAFG00020001769	EIF4EBP1	100	94.915	Canis_lupus_dingo
ENSG00000187840	EIF4EBP1	100	93.220	ENSCHIG00000019087	EIF4EBP1	100	93.220	Capra_hircus
ENSG00000187840	EIF4EBP1	59	94.286	ENSTSYG00000029045	EIF4EBP1	80	94.286	Carlito_syrichta
ENSG00000187840	EIF4EBP1	58	86.957	ENSCAPG00000011075	EIF4EBP1	100	86.957	Cavia_aperea
ENSG00000187840	EIF4EBP1	100	92.373	ENSCPOG00000039903	EIF4EBP1	100	92.373	Cavia_porcellus
ENSG00000187840	EIF4EBP1	100	96.610	ENSCCAG00000036139	EIF4EBP1	100	96.610	Cebus_capucinus
ENSG00000187840	EIF4EBP1	100	97.458	ENSCATG00000044432	EIF4EBP1	100	97.458	Cercocebus_atys
ENSG00000187840	EIF4EBP1	100	93.220	ENSCLAG00000005481	EIF4EBP1	100	93.220	Chinchilla_lanigera
ENSG00000187840	EIF4EBP1	100	96.610	ENSCSAG00000018808	-	100	96.610	Chlorocebus_sabaeus
ENSG00000187840	EIF4EBP1	100	96.610	ENSCSAG00000015504	-	100	96.610	Chlorocebus_sabaeus
ENSG00000187840	EIF4EBP1	96	67.826	ENSCPBG00000005778	EIF4EBP1	97	67.826	Chrysemys_picta_bellii
ENSG00000187840	EIF4EBP1	96	83.186	ENSCANG00000021244	EIF4EBP1	100	96.809	Colobus_angolensis_palliatus
ENSG00000187840	EIF4EBP1	100	91.525	ENSCGRG00001012311	Eif4ebp1	100	91.525	Cricetulus_griseus_chok1gshd
ENSG00000187840	EIF4EBP1	100	91.525	ENSCGRG00000008497	Eif4ebp1	100	91.525	Cricetulus_griseus_crigri
ENSG00000187840	EIF4EBP1	93	56.140	ENSCSEG00000013360	-	96	56.140	Cynoglossus_semilaevis
ENSG00000187840	EIF4EBP1	100	54.400	ENSCSEG00000005182	eif4ebp1	100	54.400	Cynoglossus_semilaevis
ENSG00000187840	EIF4EBP1	100	48.305	ENSCSEG00000014602	-	100	48.305	Cynoglossus_semilaevis
ENSG00000187840	EIF4EBP1	97	55.200	ENSCVAG00000012901	eif4ebp1	99	55.200	Cyprinodon_variegatus
ENSG00000187840	EIF4EBP1	97	56.780	ENSCVAG00000010306	-	98	56.780	Cyprinodon_variegatus
ENSG00000187840	EIF4EBP1	100	58.537	ENSDARG00000043608	eif4ebp1	100	58.537	Danio_rerio
ENSG00000187840	EIF4EBP1	93	90.000	ENSDNOG00000043024	EIF4EBP1	94	90.000	Dasypus_novemcinctus
ENSG00000187840	EIF4EBP1	100	93.220	ENSDORG00000024200	Eif4ebp1	100	93.220	Dipodomys_ordii
ENSG00000187840	EIF4EBP1	92	84.404	ENSETEG00000004669	EIF4EBP1	100	84.404	Echinops_telfairi
ENSG00000187840	EIF4EBP1	100	95.763	ENSEASG00005016688	EIF4EBP1	100	95.763	Equus_asinus_asinus
ENSG00000187840	EIF4EBP1	59	94.286	ENSECAG00000015719	EIF4EBP1	58	85.000	Equus_caballus
ENSG00000187840	EIF4EBP1	92	56.140	ENSELUG00000013938	4EBP2	93	56.140	Esox_lucius
ENSG00000187840	EIF4EBP1	100	91.525	ENSFCAG00000010425	EIF4EBP1	100	91.525	Felis_catus
ENSG00000187840	EIF4EBP1	62	64.384	ENSFALG00000006751	EIF4EBP1	100	64.384	Ficedula_albicollis
ENSG00000187840	EIF4EBP1	72	89.412	ENSFDAG00000008763	EIF4EBP1	100	89.412	Fukomys_damarensis
ENSG00000187840	EIF4EBP1	82	59.794	ENSFHEG00000016580	EIF4EBP1	77	59.794	Fundulus_heteroclitus
ENSG00000187840	EIF4EBP1	91	50.000	ENSFHEG00000011737	eif4ebp1	93	50.000	Fundulus_heteroclitus
ENSG00000187840	EIF4EBP1	92	57.143	ENSGMOG00000016807	eif4ebp1	93	57.143	Gadus_morhua
ENSG00000187840	EIF4EBP1	96	58.261	ENSGMOG00000012219	EIF4EBP1	97	58.261	Gadus_morhua
ENSG00000187840	EIF4EBP1	100	64.706	ENSGALG00000003205	EIF4EBP1	100	64.706	Gallus_gallus
ENSG00000187840	EIF4EBP1	97	56.303	ENSGAFG00000018368	EIF4EBP1	98	56.303	Gambusia_affinis
ENSG00000187840	EIF4EBP1	100	50.781	ENSGAFG00000005725	eif4ebp1	100	50.781	Gambusia_affinis
ENSG00000187840	EIF4EBP1	100	65.254	ENSGAGG00000024040	-	100	65.254	Gopherus_agassizii
ENSG00000187840	EIF4EBP1	84	55.556	ENSGAGG00000025596	-	94	55.556	Gopherus_agassizii
ENSG00000187840	EIF4EBP1	100	56.911	ENSHBUG00000023513	eif4ebp1	100	56.911	Haplochromis_burtoni
ENSG00000187840	EIF4EBP1	97	53.846	ENSHBUG00000006107	-	98	53.846	Haplochromis_burtoni
ENSG00000187840	EIF4EBP1	100	94.915	ENSHGLG00000002957	EIF4EBP1	100	94.915	Heterocephalus_glaber_female
ENSG00000187840	EIF4EBP1	58	91.304	ENSHGLG00100010994	EIF4EBP1	100	91.304	Heterocephalus_glaber_male
ENSG00000187840	EIF4EBP1	95	55.652	ENSHCOG00000010913	-	97	55.652	Hippocampus_comes
ENSG00000187840	EIF4EBP1	91	53.982	ENSHCOG00000004999	eif4ebp1	92	53.982	Hippocampus_comes
ENSG00000187840	EIF4EBP1	92	64.865	ENSIPUG00000004953	eif4ebp1	94	64.865	Ictalurus_punctatus
ENSG00000187840	EIF4EBP1	100	75.630	ENSSTOG00000022960	-	97	78.992	Ictidomys_tridecemlineatus
ENSG00000187840	EIF4EBP1	100	96.610	ENSSTOG00000006816	-	100	96.610	Ictidomys_tridecemlineatus
ENSG00000187840	EIF4EBP1	100	90.756	ENSJJAG00000011773	Eif4ebp1	100	90.756	Jaculus_jaculus
ENSG00000187840	EIF4EBP1	97	56.780	ENSKMAG00000017930	-	98	56.780	Kryptolebias_marmoratus
ENSG00000187840	EIF4EBP1	100	54.098	ENSKMAG00000013857	eif4ebp1	100	54.098	Kryptolebias_marmoratus
ENSG00000187840	EIF4EBP1	100	56.557	ENSLBEG00000011576	eif4ebp1	100	56.557	Labrus_bergylta
ENSG00000187840	EIF4EBP1	97	54.622	ENSLBEG00000004127	EIF4EBP1	98	54.622	Labrus_bergylta
ENSG00000187840	EIF4EBP1	100	67.797	ENSLACG00000007967	EIF4EBP1	100	67.797	Latimeria_chalumnae
ENSG00000187840	EIF4EBP1	97	62.712	ENSLOCG00000016072	-	98	62.712	Lepisosteus_oculatus
ENSG00000187840	EIF4EBP1	100	88.983	ENSLAFG00000026054	EIF4EBP1	100	88.983	Loxodonta_africana
ENSG00000187840	EIF4EBP1	100	97.458	ENSMFAG00000000356	EIF4EBP1	100	97.458	Macaca_fascicularis
ENSG00000187840	EIF4EBP1	100	97.458	ENSMMUG00000038480	EIF4EBP1	100	97.458	Macaca_mulatta
ENSG00000187840	EIF4EBP1	100	97.458	ENSMNEG00000032437	EIF4EBP1	100	97.458	Macaca_nemestrina
ENSG00000187840	EIF4EBP1	62	95.890	ENSMLEG00000002855	EIF4EBP1	100	95.890	Mandrillus_leucophaeus
ENSG00000187840	EIF4EBP1	97	59.649	ENSMAMG00000016712	EIF4EBP1	98	59.649	Mastacembelus_armatus
ENSG00000187840	EIF4EBP1	81	58.333	ENSMAMG00000006358	eif4ebp1	75	58.333	Mastacembelus_armatus
ENSG00000187840	EIF4EBP1	100	56.098	ENSMZEG00005016890	eif4ebp1	100	56.098	Maylandia_zebra
ENSG00000187840	EIF4EBP1	97	53.846	ENSMZEG00005017513	-	98	53.846	Maylandia_zebra
ENSG00000187840	EIF4EBP1	59	65.714	ENSMGAG00000002216	EIF4EBP1	100	65.714	Meleagris_gallopavo
ENSG00000187840	EIF4EBP1	100	91.525	ENSMAUG00000013038	Eif4ebp1	100	91.525	Mesocricetus_auratus
ENSG00000187840	EIF4EBP1	100	94.915	ENSMICG00000014636	EIF4EBP1	100	94.915	Microcebus_murinus
ENSG00000187840	EIF4EBP1	100	90.678	ENSMOCG00000001602	Eif4ebp1	100	90.678	Microtus_ochrogaster
ENSG00000187840	EIF4EBP1	97	54.918	ENSMMOG00000017511	-	98	54.918	Mola_mola
ENSG00000187840	EIF4EBP1	100	51.220	ENSMMOG00000021217	-	100	51.220	Mola_mola
ENSG00000187840	EIF4EBP1	100	82.203	ENSMODG00000010768	EIF4EBP1	100	82.203	Monodelphis_domestica
ENSG00000187840	EIF4EBP1	92	55.652	ENSMALG00000012228	eif4ebp1	94	55.652	Monopterus_albus
ENSG00000187840	EIF4EBP1	97	55.556	ENSMALG00000012932	EIF4EBP1	98	55.556	Monopterus_albus
ENSG00000187840	EIF4EBP1	100	89.831	MGP_CAROLIEiJ_G0030948	Eif4ebp1	100	89.831	Mus_caroli
ENSG00000187840	EIF4EBP1	100	90.678	ENSMUSG00000031490	Eif4ebp1	100	90.678	Mus_musculus
ENSG00000187840	EIF4EBP1	100	89.916	MGP_PahariEiJ_G0021418	Eif4ebp1	100	89.916	Mus_pahari
ENSG00000187840	EIF4EBP1	100	90.678	MGP_SPRETEiJ_G0032067	Eif4ebp1	100	90.678	Mus_spretus
ENSG00000187840	EIF4EBP1	100	93.220	ENSMPUG00000009919	EIF4EBP1	100	93.220	Mustela_putorius_furo
ENSG00000187840	EIF4EBP1	100	94.068	ENSMLUG00000007526	EIF4EBP1	100	94.068	Myotis_lucifugus
ENSG00000187840	EIF4EBP1	97	52.991	ENSNBRG00000009600	-	98	52.991	Neolamprologus_brichardi
ENSG00000187840	EIF4EBP1	100	57.500	ENSNBRG00000009633	eif4ebp1	100	57.500	Neolamprologus_brichardi
ENSG00000187840	EIF4EBP1	100	82.203	ENSMEUG00000015904	EIF4EBP1	100	82.203	Notamacropus_eugenii
ENSG00000187840	EIF4EBP1	100	90.678	ENSOPRG00000000317	EIF4EBP1	100	90.678	Ochotona_princeps
ENSG00000187840	EIF4EBP1	100	91.525	ENSODEG00000005774	EIF4EBP1	100	91.525	Octodon_degus
ENSG00000187840	EIF4EBP1	97	53.846	ENSONIG00000013351	-	98	53.846	Oreochromis_niloticus
ENSG00000187840	EIF4EBP1	59	77.143	ENSOANG00000007344	-	100	77.143	Ornithorhynchus_anatinus
ENSG00000187840	EIF4EBP1	98	91.379	ENSOCUG00000017792	EIF4EBP1	98	91.379	Oryctolagus_cuniculus
ENSG00000187840	EIF4EBP1	100	53.226	ENSORLG00000028190	eif4ebp1	100	53.226	Oryzias_latipes
ENSG00000187840	EIF4EBP1	71	66.667	ENSORLG00000006498	-	61	66.667	Oryzias_latipes
ENSG00000187840	EIF4EBP1	97	55.556	ENSORLG00020016341	-	98	55.556	Oryzias_latipes_hni
ENSG00000187840	EIF4EBP1	100	53.226	ENSORLG00020010439	eif4ebp1	100	53.226	Oryzias_latipes_hni
ENSG00000187840	EIF4EBP1	71	63.095	ENSORLG00015023253	-	54	63.095	Oryzias_latipes_hsok
ENSG00000187840	EIF4EBP1	97	55.556	ENSORLG00015004636	-	98	55.556	Oryzias_latipes_hsok
ENSG00000187840	EIF4EBP1	97	58.261	ENSOMEG00000001869	-	98	58.261	Oryzias_melastigma
ENSG00000187840	EIF4EBP1	100	51.200	ENSOMEG00000021742	eif4ebp1	100	51.200	Oryzias_melastigma
ENSG00000187840	EIF4EBP1	100	92.373	ENSOGAG00000032329	EIF4EBP1	100	92.373	Otolemur_garnettii
ENSG00000187840	EIF4EBP1	100	93.220	ENSOARG00000001124	EIF4EBP1	98	93.220	Ovis_aries
ENSG00000187840	EIF4EBP1	100	94.068	ENSPPAG00000036659	EIF4EBP1	100	94.068	Pan_paniscus
ENSG00000187840	EIF4EBP1	100	91.525	ENSPPRG00000008612	EIF4EBP1	100	91.525	Panthera_pardus
ENSG00000187840	EIF4EBP1	81	91.579	ENSPTIG00000016464	EIF4EBP1	81	91.579	Panthera_tigris_altaica
ENSG00000187840	EIF4EBP1	100	97.458	ENSPANG00000024757	EIF4EBP1	100	97.458	Papio_anubis
ENSG00000187840	EIF4EBP1	100	60.317	ENSPKIG00000002110	eif4ebp1	100	60.317	Paramormyrops_kingsleyae
ENSG00000187840	EIF4EBP1	100	59.322	ENSPMGG00000012705	eif4ebp1	100	59.322	Periophthalmus_magnuspinnatus
ENSG00000187840	EIF4EBP1	100	91.525	ENSPEMG00000009917	Eif4ebp1	100	91.525	Peromyscus_maniculatus_bairdii
ENSG00000187840	EIF4EBP1	91	52.991	ENSPFOG00000006081	eif4ebp1	66	52.991	Poecilia_formosa
ENSG00000187840	EIF4EBP1	97	57.983	ENSPFOG00000008954	-	98	57.983	Poecilia_formosa
ENSG00000187840	EIF4EBP1	97	57.983	ENSPLAG00000016860	EIF4EBP1	98	57.983	Poecilia_latipinna
ENSG00000187840	EIF4EBP1	100	51.562	ENSPLAG00000004199	eif4ebp1	100	51.562	Poecilia_latipinna
ENSG00000187840	EIF4EBP1	100	50.781	ENSPMEG00000018617	eif4ebp1	100	50.781	Poecilia_mexicana
ENSG00000187840	EIF4EBP1	97	56.303	ENSPMEG00000023893	-	98	56.303	Poecilia_mexicana
ENSG00000187840	EIF4EBP1	100	50.407	ENSPREG00000006324	eif4ebp1	100	50.407	Poecilia_reticulata
ENSG00000187840	EIF4EBP1	98	57.851	ENSPREG00000021678	EIF4EBP1	97	57.851	Poecilia_reticulata
ENSG00000187840	EIF4EBP1	100	100.000	ENSPPYG00000018518	EIF4EBP1	100	100.000	Pongo_abelii
ENSG00000187840	EIF4EBP1	100	87.288	ENSPCAG00000009025	EIF4EBP1	100	87.288	Procavia_capensis
ENSG00000187840	EIF4EBP1	100	95.763	ENSPCOG00000006624	-	100	95.763	Propithecus_coquereli
ENSG00000187840	EIF4EBP1	100	96.610	ENSPCOG00000021010	-	100	96.610	Propithecus_coquereli
ENSG00000187840	EIF4EBP1	100	93.220	ENSPVAG00000006013	EIF4EBP1	100	93.220	Pteropus_vampyrus
ENSG00000187840	EIF4EBP1	95	55.652	ENSPNYG00000015057	-	97	55.652	Pundamilia_nyererei
ENSG00000187840	EIF4EBP1	100	56.911	ENSPNYG00000011640	eif4ebp1	100	56.911	Pundamilia_nyererei
ENSG00000187840	EIF4EBP1	99	59.167	ENSPNAG00000015895	eif4ebp1	97	59.483	Pygocentrus_nattereri
ENSG00000187840	EIF4EBP1	100	92.373	ENSRNOG00000012582	Eif4ebp1	100	92.373	Rattus_norvegicus
ENSG00000187840	EIF4EBP1	99	96.581	ENSRBIG00000021714	-	100	96.581	Rhinopithecus_bieti
ENSG00000187840	EIF4EBP1	100	96.610	ENSRBIG00000029887	-	100	96.610	Rhinopithecus_bieti
ENSG00000187840	EIF4EBP1	100	97.458	ENSRROG00000045656	EIF4EBP1	100	97.458	Rhinopithecus_roxellana
ENSG00000187840	EIF4EBP1	59	95.714	ENSSBOG00000000833	EIF4EBP1	85	95.714	Saimiri_boliviensis_boliviensis
ENSG00000187840	EIF4EBP1	58	72.059	ENSSHAG00000017097	-	89	72.059	Sarcophilus_harrisii
ENSG00000187840	EIF4EBP1	100	60.976	ENSSFOG00015019276	EIF4EBP1	100	60.976	Scleropages_formosus
ENSG00000187840	EIF4EBP1	97	60.000	ENSSFOG00015003469	-	98	60.000	Scleropages_formosus
ENSG00000187840	EIF4EBP1	97	59.483	ENSSMAG00000015759	-	98	59.483	Scophthalmus_maximus
ENSG00000187840	EIF4EBP1	100	53.488	ENSSDUG00000020734	eif4ebp1	100	53.488	Seriola_dumerili
ENSG00000187840	EIF4EBP1	97	58.475	ENSSDUG00000017281	-	98	58.475	Seriola_dumerili
ENSG00000187840	EIF4EBP1	100	53.488	ENSSLDG00000018599	eif4ebp1	100	53.488	Seriola_lalandi_dorsalis
ENSG00000187840	EIF4EBP1	100	58.197	ENSSLDG00000016596	-	100	58.197	Seriola_lalandi_dorsalis
ENSG00000187840	EIF4EBP1	100	56.667	ENSSPAG00000001256	eif4ebp1	69	56.667	Stegastes_partitus
ENSG00000187840	EIF4EBP1	97	58.475	ENSSPAG00000015519	-	98	58.475	Stegastes_partitus
ENSG00000187840	EIF4EBP1	100	90.000	ENSSSCG00000022301	EIF4EBP1	100	90.000	Sus_scrofa
ENSG00000187840	EIF4EBP1	100	62.185	ENSTGUG00000004721	EIF4EBP1	100	62.185	Taeniopygia_guttata
ENSG00000187840	EIF4EBP1	100	51.220	ENSTRUG00000020480	-	100	51.220	Takifugu_rubripes
ENSG00000187840	EIF4EBP1	93	50.909	ENSTRUG00000024442	-	95	50.909	Takifugu_rubripes
ENSG00000187840	EIF4EBP1	100	53.600	ENSTNIG00000013238	-	98	53.600	Tetraodon_nigroviridis
ENSG00000187840	EIF4EBP1	92	91.667	ENSTBEG00000005815	EIF4EBP1	100	91.667	Tupaia_belangeri
ENSG00000187840	EIF4EBP1	100	90.678	ENSTTRG00000004474	EIF4EBP1	100	90.678	Tursiops_truncatus
ENSG00000187840	EIF4EBP1	100	94.068	ENSUAMG00000023500	EIF4EBP1	100	94.068	Ursus_americanus
ENSG00000187840	EIF4EBP1	59	90.000	ENSUMAG00000009121	EIF4EBP1	64	90.000	Ursus_maritimus
ENSG00000187840	EIF4EBP1	100	94.915	ENSVVUG00000020168	EIF4EBP1	100	94.915	Vulpes_vulpes
ENSG00000187840	EIF4EBP1	97	57.983	ENSXCOG00000017375	-	98	57.983	Xiphophorus_couchianus
ENSG00000187840	EIF4EBP1	100	50.394	ENSXCOG00000005316	eif4ebp1	100	50.394	Xiphophorus_couchianus
ENSG00000187840	EIF4EBP1	97	57.983	ENSXMAG00000017888	-	98	57.983	Xiphophorus_maculatus
ENSG00000187840	EIF4EBP1	100	50.781	ENSXMAG00000025049	eif4ebp1	100	50.781	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000082	G1/S transition of mitotic cell cycle	14673156.	IMP	Process
GO:0002192	IRES-dependent translational initiation of linear mRNA	-	IEA	Process
GO:0002931	response to ischemia	-	IEA	Process
GO:0005515	protein binding	7651417.10772338.12150925.12150926.15153109.16189514.16271312.16504179.17368478.18337751.18955708.19834456.20224576.20671708.20880835.21191102.22678294.24211447.25416956.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	23814182.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0008190	eukaryotic initiation factor 4E binding	21873635.	IBA	Function
GO:0008190	eukaryotic initiation factor 4E binding	23814182.	IDA	Function
GO:0008286	insulin receptor signaling pathway	-	IEA	Process
GO:0030324	lung development	-	IEA	Process
GO:0030371	translation repressor activity	22578813.	IDA	Function
GO:0031333	negative regulation of protein complex assembly	-	IEA	Process
GO:0031929	TOR signaling	12150926.22578813.	IDA	Process
GO:0032991	protein-containing complex	-	IEA	Component
GO:0045471	response to ethanol	-	IEA	Process
GO:0045931	positive regulation of mitotic cell cycle	14673156.	IMP	Process
GO:0045947	negative regulation of translational initiation	21873635.	IBA	Process
GO:0045947	negative regulation of translational initiation	22578813.	IDA	Process
GO:0051721	protein phosphatase 2A binding	-	IEA	Function
GO:0071456	cellular response to hypoxia	-	IEA	Process
GO:0071549	cellular response to dexamethasone stimulus	-	IEA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099524	postsynaptic cytosol	-	IEA	Component
GO:1990928	response to amino acid starvation	-	IEA	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.