EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
12927047Beta class II tubulin predominates in normal and tumor breast tissues.Breast Cancer Res2003Dozier JH-
12037579Occurrence of nuclear beta(II)-tubulin in cultured cells.Cell Tissue Res2002 MayWalss-Bass C-
20872967Up-regulation of hnRNP A1, Ezrin, tubulin β-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer.World J Gastroenterol2010 Oct 7He ZY-
15548702Nuclear betaII-tubulin associates with the activated notch receptor to modulate notch signaling.Cancer Res2004 Nov 15Yeh TS-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr9137242405Intronnovel0.46
BLCAchr91372436793'UTRnovel0.54
BLCAchr91372413435'UTRnovel0.08
BLCAchr9137242500Missense_MutationnovelQ94H0.27
BLCAchr9137243294Missense_Mutationrs747212339R359Q0.24
BLCAchr9137243352Missense_MutationNAF378L0.34
BRCAchr9137242578SilentnovelV120V0.04
BRCAchr9137243534Missense_MutationnovelE439G0.1
BRCAchr9137243463Missense_MutationNAM415I0.23
BRCAchr9137243500Missense_MutationNAA428T0.3
BRCAchr9137243013Missense_MutationnovelF265L0.14
BRCAchr91372436063'UTRnovel0.14
CESCchr9137242491Splice_Regionnovel0.46
CESCchr9137242500Missense_MutationnovelQ94H0.41
CESCchr9137243079Silentrs772348490P287P0.38
CESCchr9137243293Missense_MutationNAR359W0.46
CESCchr9137242428Intronnovel0.27
COADchr9137242589Missense_MutationNAA124V0.27
COADchr9137242050Intronnovel0.35
COADchr91372413385'UTRnovel0.29
COADchr91372436433'UTRnovel0.28
COADchr9137241382Nonsense_MutationnovelQ8*0.14
COADchr91372413535'UTRnovel0.52
COADchr9137243074Missense_MutationNAV286M0.3
COADchr9137242657Missense_MutationnovelM147V0.21
COADchr9137242602SilentnovelD128D0.53
COADchr9137243445Silentrs770443576T409T0.23
GBMchr9137243296Missense_MutationnovelG360R0.2
GBMchr9137243248Missense_MutationnovelW344G0.16
HNSCchr9137242548Silentrs148569376A110A0.3
HNSCchr9137243521Missense_MutationnovelE435K0.52
HNSCchr9137243079Silentrs772348490P287P0.54
KIRCchr9137242956Silentrs151064868L246L0.15
KIRCchr91372436363'UTRnovel0.32
KIRCchr9137242908SilentNAS230S0.17
KIRPchr9137242580Frame_Shift_InsnovelE123Gfs*30.32
KIRPchr9137242937Missense_MutationNAL240P0.51
LGGchr9137242989Missense_MutationNAM257I0.12
LGGchr9137241810SilentNAV49V0.1
LGGchr9137242809Silentrs765513816D197D0.14
LGGchr91372436223'UTRnovel0.38
LIHCchr9137242336Intronnovel0.36
LIHCchr9137243216Missense_MutationNAV333A0.31
LUADchr9137241995Missense_MutationnovelI84N0.37
LUADchr91372413525'UTRnovel0.2
LUADchr9137242030Intronnovel0.19
LUADchr9137243023Missense_MutationnovelG269S0.21
LUADchr9137243419Missense_MutationNAE401Q0.37
LUADchr9137243502SilentNAA428A0.51
LUSCchr91372413455'UTRrs5560361770.83
LUSCchr9137242812SilentnovelE198E0.24
LUSCchr9137243390Frame_Shift_DelnovelR391Pfs*250.28
LUSCchr9137243391SilentnovelR391R0.29
LUSCchr91372413465'UTRnovel0.44
LUSCchr9137243079SilentnovelP287P0.36
LUSCchr9137242421Intronnovel0.14
LUSCchr9137242747Missense_MutationnovelD177H0.27
LUSCchr9137243494Missense_MutationnovelQ426E0.05
LUSCchr9137243177Missense_MutationNAR320H0.43
LUSCchr9137242619Missense_MutationnovelQ134L0.07
LUSCchr9137241777SilentnovelG38G0.48
MESOchr9137243299SilentnovelL361L0.25
OVchr9137243440Missense_MutationNAF408I0.32
OVchr91372413255'UTRrs7680005350.35
READchr9137241387SilentnovelA9A0.14
READchr9137243436Missense_MutationNAM406I0.27
SARCchr9137243104Missense_MutationnovelA296T0.1
SKCMchr9137242021Missense_MutationNAG93S0.32
SKCMchr9137243349SilentnovelL377L0.9
SKCMchr9137243526SilentnovelF436F0.34
SKCMchr91372435603'UTRrs7625979200.26
SKCMchr9137243137Missense_Mutationrs762659681H307Y0.25
STADchr9137243095Missense_MutationNAM293V0.18
STADchr91372436893'UTRnovel0.09
STADchr9137242638Frame_Shift_InsnovelT143Dfs*260.44
STADchr9137242988Missense_MutationNAM257T0.16
STADchr9137243497Missense_MutationNAD427N0.24
STADchr9137241815Missense_MutationNAY51C0.35
THCAchr91372413435'UTRnovel0.1
THCAchr9137242589Missense_MutationNAA124G0.36
THCAchr91372412805'UTRnovel0.33
UCECchr91372435843'UTRnovel0.29
UCECchr9137242368Intronnovel0.29
UCECchr9137241918Missense_MutationnovelK58N0.18
UCECchr9137241939SilentnovelL65L0.22
UCECchr91372435923'UTRnovel0.14
UCECchr9137241964Missense_MutationnovelD74N0.25
UCECchr9137243063Missense_MutationnovelR282Q0.32
UCECchr9137243543Missense_MutationnovelE442G0.25
UCECchr9137243334Silentrs760204112T372T0.38
UCECchr9137243414Missense_MutationNAT399M0.15
UCECchr91372436643'UTRrs7807633060.46
UCECchr9137243116Missense_MutationnovelM300L0.35
UCECchr9137241988Missense_MutationNAG82W0.26
UCECchr9137242017SilentnovelV91V0.17
UCECchr9137243123Missense_MutationnovelA302V0.47
UCECchr9137243092Nonsense_MutationnovelQ292*0.42
UCECchr9137243080Missense_MutationnovelE288K0.37
UCECchr9137242771Missense_MutationNAA185T0.3
UCECchr9137243177Missense_MutationNAR320H0.37
UCECchr9137243390Missense_MutationnovelR391H0.4
UCECchr9137243161Missense_MutationnovelA315T0.32

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCADEL0.19720.070727
ESCAAMP0.27720.24147
LAMLDEL0.01050.24147
LGGAMP0.07210.21332
LIHCDEL0.24860.12467
OVDEL0.49742.9521e-06
SARCDEL0.22180.00032085
STADAMP0.21320.0047873
THCADEL0.04010.24038
THYMDEL0.01630.022012
UCSDEL0.58930.089783

Survival Analysis
CancerP-value Q-value
THYM0.035

Kaplan-Meier Survival Analysis

STAD0.0086

Kaplan-Meier Survival Analysis

ACC0.0001

Kaplan-Meier Survival Analysis

UCS0.0076

Kaplan-Meier Survival Analysis

SKCM0.0001

Kaplan-Meier Survival Analysis

TGCT0.047

Kaplan-Meier Survival Analysis

CESC0.0035

Kaplan-Meier Survival Analysis

LAML0.011

Kaplan-Meier Survival Analysis

UCEC0.00011

Kaplan-Meier Survival Analysis

GBM0.032

Kaplan-Meier Survival Analysis

LIHC0.0083

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

THCA0.014

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000188229 (Gene tree)
Gene ID
10383
Gene Symbol
TUBB4B
Alias
Beta2|TUBB2C
Full Name
tubulin beta 4B class IVb
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
2,495 bases
Position
chr9:137,241,213-137,243,707
Accession
20771
RBP type
non-canonical RBP
Summary
(Tubulin Beta 4B Class IVb) is a Protein Coding gene. Diseases associated with TUBB4B include Leber Congenital Amaurosis With Early-Onset Deafness and Tubulin, Beta. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. Gene Ontology (GO) annotations related to this gene include GTP binding and unfolded protein binding. An important paralog of this gene is TUBB4A.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
23672475Differentially expressed proteins in the skin mucus of Atlantic cod (Gadus morhua) upon natural infection with Vibrio anguillarum.BMC Vet Res2013 May 14Rajan Bdoi: 10.1186/1746-6148-9-103.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000340384TUBB4B-2011637-ENSP00000341289445 (aa)-P68371
ENST00000604929TUBB4B-2022035--- (aa)--
Gene Model
Click here to download ENSG00000188229's gene model file
Pathways
Pathway IDPathway NameSource
hsa04145PhagosomeKEGG
hsa04540Gap junctionKEGG
hsa05130Pathogenic Escherichia coli infectionKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000188229's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000188229TUBB4B9994.344WBGene00006538tbb-49695.785Caenorhabditis_elegans
ENSG00000188229TUBB4B10098.876ENSDARG00000002344tubb4b10098.876Danio_rerio
ENSG00000188229TUBB4B100100.000ENSMUSG00000036752Tubb4b100100.000Mus_musculus
ENSG00000188229TUBB4B9975.737YFL037WTUB29377.049Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000086G2/M transition of mitotic cell cycle-TASProcess
GO:0000226microtubule cytoskeleton organization21873635.IBAProcess
GO:0000278mitotic cell cycle21873635.IBAProcess
GO:0003725double-stranded RNA binding21266579.IDAFunction
GO:0003924GTPase activity-IEAFunction
GO:0005200structural constituent of cytoskeleton21873635.IBAFunction
GO:0005525GTP binding21873635.IBAFunction
GO:0005576extracellular region-TASComponent
GO:0005634nucleus21630459.HDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0005856cytoskeleton16130169.TASComponent
GO:0005874microtubule21873635.IBAComponent
GO:0005874microtubule21525035.IDAComponent
GO:0007017microtubule-based process21873635.IBAProcess
GO:0010389regulation of G2/M transition of mitotic cell cycle-TASProcess
GO:0035578azurophil granule lumen-TASComponent
GO:0042267natural killer cell mediated cytotoxicity11120798.NASProcess
GO:0042288MHC class I protein binding11120798.TASFunction
GO:0043312neutrophil degranulation-TASProcess
GO:0051082unfolded protein binding11120798.NASFunction
GO:0070062extracellular exosome11487543.20458337.23533145.HDAComponent
GO:0097711ciliary basal body-plasma membrane docking-TASProcess
GO:1903561extracellular vesicle24769233.HDAComponent
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