EuRBPDB

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Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18223680	The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression.	Oncogene	2008 Jun 12	Bonnomet A	doi: 10.1038/sj.onc.1211035
17047063	E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion.	Cancer Res	2006 Oct 15	Strumane K	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr10	119032625	3'UTR	novel		0.2
ACC	chr10	119031773	3'UTR	novel		0.31
BRCA	chr10	119033308	3'UTR	novel		0.23
BRCA	chr10	119032701	3'UTR	novel		0.05
CESC	chr10	119032967	3'UTR	rs543050464		0.32
CESC	chr10	119030866	3'UTR	novel		0.28
CHOL	chr10	119032179	3'UTR	novel		0.24
COAD	chr10	119032556	3'UTR	novel		0.41
COAD	chr10	119030996	3'UTR	novel		0.17
COAD	chr10	119031079	3'UTR	novel		0.4
COAD	chr10	119030477	Missense_Mutation	novel	L226F	0.24	zf-nanos
COAD	chr10	119032612	3'UTR	novel		0.17
COAD	chr10	119033305	3'UTR	novel		0.17
COAD	chr10	119033386	3'UTR	rs551009384		0.2
COAD	chr10	119032271	3'UTR	novel		0.18
COAD	chr10	119030910	3'UTR	novel		0.06
COAD	chr10	119033227	3'UTR	novel		0.42
COAD	chr10	119031074	3'UTR	novel		0.21
COAD	chr10	119031547	3'UTR	novel		0.31
ESCA	chr10	119032862	3'UTR	novel		0.75
ESCA	chr10	119032661	3'UTR	novel		0.09
KIRC	chr10	119030788	3'UTR	novel		0.26
KIRP	chr10	119031425	3'UTR	novel		0.51
KIRP	chr10	119032554	3'UTR	novel		0.23
KIRP	chr10	119031707	3'UTR	novel		0.25
LIHC	chr10	119032308	3'UTR	novel		0.15
LIHC	chr10	119031457	3'UTR	novel		0.14
LIHC	chr10	119032243	3'UTR	novel		0.42
LIHC	chr10	119031375	3'UTR	novel		0.4
LIHC	chr10	119031564	3'UTR	novel		0.49
LUAD	chr10	119030579	In_Frame_Ins	novel	H260delinsRY	0.14	zf-nanos
LUAD	chr10	119030428	Silent	rs143230641	P209P	0.27
LUAD	chr10	119030542	Nonsense_Mutation	novel	Y247*	0.29	zf-nanos
LUSC	chr10	119030587	In_Frame_Del	novel	Y264_K269del	0.11	zf-nanos
READ	chr10	119031236	3'UTR	novel		0.18
READ	chr10	119032464	3'UTR	novel		0.19
READ	chr10	119033356	3'UTR	novel		0.13
SARC	chr10	119032866	3'UTR	novel		0.24
UCEC	chr10	119033374	3'UTR	novel		0.08
UCEC	chr10	119031928	3'UTR	novel		0.1
UCEC	chr10	119033605	3'UTR	novel		0.57
UCEC	chr10	119032829	3'UTR	novel		0.05
UCEC	chr10	119031048	3'UTR	novel		0.24
UCEC	chr10	119030906	3'UTR	novel		0.43
UCEC	chr10	119032048	3'UTR	novel		0.23
UCEC	chr10	119033100	3'UTR	novel		0.47
UCEC	chr10	119030986	3'UTR	novel		0.34
UCEC	chr10	119031829	3'UTR	novel		0.16
UCEC	chr10	119030954	3'UTR	novel		0.48
UCEC	chr10	119031567	3'UTR	novel		0.36
UCEC	chr10	119033455	3'UTR	novel		0.27
UCEC	chr10	119031005	3'UTR	novel		0.44
UCEC	chr10	119032109	3'UTR	novel		0.48
UCEC	chr10	119032477	3'UTR	novel		0.52
UCEC	chr10	119033068	3'UTR	novel		0.36
UCEC	chr10	119032696	3'UTR	novel		0.39
UCEC	chr10	119031752	3'UTR	novel		0.61
UCEC	chr10	119032471	3'UTR	rs537491266		0.19
UCEC	chr10	119032071	3'UTR	novel		0.21
UCEC	chr10	119033240	3'UTR	novel		0.24
UCEC	chr10	119033553	3'UTR	novel		0.25
UCEC	chr10	119032048	3'UTR	novel		0.45
UCEC	chr10	119031743	3'UTR	novel		0.58
UCEC	chr10	119031176	3'UTR	novel		0.17
UCEC	chr10	119032200	3'UTR	novel		0.48
UCEC	chr10	119033423	3'UTR	novel		0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
CHOL	DEL	0.2778	0.048655
COAD	DEL	0.1552	9.4741e-07
HNSC	DEL	0.1609	0.22646
LGG	DEL	0.2612	4.3789e-20
LIHC	DEL	0.2486	5.7505e-06
LUAD	DEL	0.1764	0.0059643
LUSC	DEL	0.3633	0.038823
MESO	DEL	0.2874	0.00015289
OV	DEL	0.3057	5.3759e-12
PAAD	DEL	0.1141	0.169
PRAD	AMP	0.0122	0.016187
READ	DEL	0.2	0.014135
SKCM	DEL	0.5586	0.00079981
THYM	DEL	0.0325	0.10563
UCS	DEL	0.2857	0.1218

Survival Analysis

Cancer	P-value	Q-value
MESO	0.018	Kaplan-Meier Survival Analysis
UCS	0.028	Kaplan-Meier Survival Analysis
SKCM	0.0027	Kaplan-Meier Survival Analysis
BRCA	0.00031	Kaplan-Meier Survival Analysis
COAD	0.042	Kaplan-Meier Survival Analysis
PAAD	0.0068	Kaplan-Meier Survival Analysis
BLCA	0.0052	Kaplan-Meier Survival Analysis
READ	0.0021	Kaplan-Meier Survival Analysis
LAML	0.0028	Kaplan-Meier Survival Analysis
UCEC	0.015	Kaplan-Meier Survival Analysis
GBM	0.02	Kaplan-Meier Survival Analysis
LIHC	0.031	Kaplan-Meier Survival Analysis
LGG	0.00015	Kaplan-Meier Survival Analysis
THCA	0.042	Kaplan-Meier Survival Analysis
LUAD	0.00059	Kaplan-Meier Survival Analysis

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000188613 (Gene tree)
Gene ID: 340719
Gene Symbol: NANOS1
Alias: NOS1|ZC2HC12A
Full Name: nanos C2HC-type zinc finger 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 4,627 bases
Position: chr10:119,029,716-119,034,342
Accession: 23044
RBP type: canonical RBP
Summary: This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000345924	zf-nanos	PF05741.13	1.1e-25	1	1
ENSP00000393275	zf-nanos	PF05741.13	1.2e-24	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10518502	nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans.	Development	1999 Nov	Subramaniam K	-
12834871	nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development.	Mech Dev	2003 Jun	Haraguchi S	-
24265795	Protein interactions in Xenopus germ plasm RNP particles.	PLoS One	2013 Nov 12	Nijjar S	doi: 10.1371/journal.pone.0080077
26609159	A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.	J Neurosci	2015 Nov 25	Amadei G	doi: 10.1523/JNEUROSCI.2172-15.2015.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000340087	NANOS1-201	1108	-	ENSP00000345924	84 (aa)	-	Q5T9H5
ENST00000425699	NANOS1-202	4017	-	ENSP00000393275	292 (aa)	-	Q8WY41

Gene Model

Click here to download ENSG00000188613's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000188613	rs186808650	10	119029751	?	Alcoholic chronic pancreatitis	28754779	[1.15-1.40]	1.2647022	EFO_1002013

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000188613's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000188613	NANOS1	75	68.254	ENSAPOG00000004421	-	50	44.118	Acanthochromis_polyacanthus
ENSG00000188613	NANOS1	100	91.765	ENSAMEG00000020160	-	96	92.135	Ailuropoda_melanoleuca
ENSG00000188613	NANOS1	99	79.518	ENSACAG00000027867	-	75	95.082	Anolis_carolinensis
ENSG00000188613	NANOS1	96	54.321	ENSACAG00000011358	-	73	60.345	Anolis_carolinensis
ENSG00000188613	NANOS1	100	96.471	ENSBTAG00000052883	NANOS1	100	78.498	Bos_taurus
ENSG00000188613	NANOS1	100	97.647	ENSCJAG00000044351	NANOS1	100	92.568	Callithrix_jacchus
ENSG00000188613	NANOS1	73	98.361	ENSCAFG00000025549	-	87	92.857	Canis_familiaris
ENSG00000188613	NANOS1	100	96.471	ENSCHIG00000004298	NANOS1	100	87.119	Capra_hircus
ENSG00000188613	NANOS1	100	91.765	ENSCPOG00000038609	NANOS1	100	73.810	Cavia_porcellus
ENSG00000188613	NANOS1	100	98.810	ENSCCAG00000009164	NANOS1	100	94.178	Cebus_capucinus
ENSG00000188613	NANOS1	100	98.810	ENSCATG00000000994	NANOS1	100	95.222	Cercocebus_atys
ENSG00000188613	NANOS1	100	91.765	ENSCLAG00000005574	NANOS1	100	71.168	Chinchilla_lanigera
ENSG00000188613	NANOS1	100	82.143	ENSCPBG00000002172	NANOS1	54	96.970	Chrysemys_picta_bellii
ENSG00000188613	NANOS1	68	52.632	ENSCANG00000034930	NANOS3	51	43.182	Colobus_angolensis_palliatus
ENSG00000188613	NANOS1	100	90.476	ENSCGRG00001007664	Nanos1	100	72.696	Cricetulus_griseus_chok1gshd
ENSG00000188613	NANOS1	75	68.254	ENSDARG00000109337	nanos1	55	42.958	Danio_rerio
ENSG00000188613	NANOS1	100	91.765	ENSDNOG00000048482	NANOS1	99	77.397	Dasypus_novemcinctus
ENSG00000188613	NANOS1	100	92.941	ENSDORG00000029226	Nanos1	100	91.860	Dipodomys_ordii
ENSG00000188613	NANOS1	68	77.193	ENSEBUG00000002646	-	54	75.862	Eptatretus_burgeri
ENSG00000188613	NANOS1	100	95.294	ENSEASG00005014466	NANOS1	100	78.498	Equus_asinus_asinus
ENSG00000188613	NANOS1	100	95.294	ENSECAG00000003656	NANOS1	100	76.109	Equus_caballus
ENSG00000188613	NANOS1	92	88.321	ENSFCAG00000040429	-	89	88.321	Felis_catus
ENSG00000188613	NANOS1	74	98.387	ENSFALG00000002196	NANOS1	92	51.439	Ficedula_albicollis
ENSG00000188613	NANOS1	63	49.057	ENSFALG00000006160	NANOS3	67	48.214	Ficedula_albicollis
ENSG00000188613	NANOS1	77	61.538	ENSGMOG00000020465	nanos1	67	62.903	Gadus_morhua
ENSG00000188613	NANOS1	73	70.492	ENSGMOG00000015980	-	55	70.968	Gadus_morhua
ENSG00000188613	NANOS1	68	52.632	ENSGMOG00000016541	nanos3	60	50.820	Gadus_morhua
ENSG00000188613	NANOS1	100	78.571	ENSGALG00000027980	NANOS1	93	49.123	Gallus_gallus
ENSG00000188613	NANOS1	73	73.770	ENSGACG00000004930	-	56	74.194	Gasterosteus_aculeatus
ENSG00000188613	NANOS1	75	68.254	ENSGACG00000016692	-	67	69.355	Gasterosteus_aculeatus
ENSG00000188613	NANOS1	100	91.765	ENSHGLG00000010622	NANOS1	91	77.941	Heterocephalus_glaber_female
ENSG00000188613	NANOS1	77	67.692	ENSIPUG00000020252	nanos1	51	41.304	Ictalurus_punctatus
ENSG00000188613	NANOS1	75	68.254	ENSLBEG00000016559	-	51	43.939	Labrus_bergylta
ENSG00000188613	NANOS1	99	75.904	ENSLACG00000015195	NANOS1	62	53.020	Latimeria_chalumnae
ENSG00000188613	NANOS1	99	56.471	ENSLACG00000005166	nanos1	52	42.424	Latimeria_chalumnae
ENSG00000188613	NANOS1	99	59.036	ENSLOCG00000018172	nanos1	50	43.939	Lepisosteus_oculatus
ENSG00000188613	NANOS1	80	79.104	ENSLOCG00000018243	NANOS1	85	37.849	Lepisosteus_oculatus
ENSG00000188613	NANOS1	100	100.000	ENSMMUG00000048654	NANOS1	100	100.000	Macaca_mulatta
ENSG00000188613	NANOS1	100	100.000	ENSMNEG00000022527	NANOS1	100	95.904	Macaca_nemestrina
ENSG00000188613	NANOS1	100	91.667	ENSMAUG00000021200	Nanos1	100	75.510	Mesocricetus_auratus
ENSG00000188613	NANOS1	100	91.667	ENSMOCG00000007708	Nanos1	100	74.658	Microtus_ochrogaster
ENSG00000188613	NANOS1	100	78.571	ENSMODG00000009319	NANOS1	89	58.423	Monodelphis_domestica
ENSG00000188613	NANOS1	100	91.667	MGP_CAROLIEiJ_G0023120	Nanos1	100	76.014	Mus_caroli
ENSG00000188613	NANOS1	100	91.667	ENSMUSG00000072437	Nanos1	100	75.254	Mus_musculus
ENSG00000188613	NANOS1	100	91.667	MGP_PahariEiJ_G0014608	Nanos1	100	77.211	Mus_pahari
ENSG00000188613	NANOS1	100	91.667	MGP_SPRETEiJ_G0024041	Nanos1	100	75.168	Mus_spretus
ENSG00000188613	NANOS1	100	92.857	ENSMLUG00000026243	-	100	92.857	Myotis_lucifugus
ENSG00000188613	NANOS1	100	88.095	ENSNGAG00000023539	Nanos1	75	95.522	Nannospalax_galili
ENSG00000188613	NANOS1	100	92.941	ENSODEG00000017556	NANOS1	100	76.014	Octodon_degus
ENSG00000188613	NANOS1	100	94.186	ENSOGAG00000033947	NANOS1	100	84.512	Otolemur_garnettii
ENSG00000188613	NANOS1	100	96.471	ENSOARG00000000575	-	86	93.458	Ovis_aries
ENSG00000188613	NANOS1	100	95.294	ENSPPRG00000021230	NANOS1	100	87.797	Panthera_pardus
ENSG00000188613	NANOS1	100	100.000	ENSPTRG00000013314	NANOS1	100	98.630	Pan_troglodytes
ENSG00000188613	NANOS1	100	98.810	ENSPANG00000000318	NANOS1	100	95.563	Papio_anubis
ENSG00000188613	NANOS1	99	80.723	ENSPSIG00000000407	-	100	80.723	Pelodiscus_sinensis
ENSG00000188613	NANOS1	100	92.857	ENSPEMG00000019116	Nanos1	100	75.085	Peromyscus_maniculatus_bairdii
ENSG00000188613	NANOS1	75	71.642	ENSPMAG00000010329	-	96	61.728	Petromyzon_marinus
ENSG00000188613	NANOS1	100	78.571	ENSPCIG00000028425	NANOS1	91	59.364	Phascolarctos_cinereus
ENSG00000188613	NANOS1	75	66.667	ENSPFOG00000020533	-	67	67.742	Poecilia_formosa
ENSG00000188613	NANOS1	69	55.172	ENSPLAG00000007786	NANOS2	50	53.226	Poecilia_latipinna
ENSG00000188613	NANOS1	69	55.172	ENSPREG00000020465	nanos2	53	53.226	Poecilia_reticulata
ENSG00000188613	NANOS1	100	94.186	ENSPCAG00000006942	NANOS1	97	75.940	Procavia_capensis
ENSG00000188613	NANOS1	100	92.941	ENSPCOG00000009467	NANOS1	100	90.816	Propithecus_coquereli
ENSG00000188613	NANOS1	100	92.941	ENSPVAG00000003146	NANOS1	100	85.085	Pteropus_vampyrus
ENSG00000188613	NANOS1	100	91.667	ENSRNOG00000025060	Nanos1	100	75.768	Rattus_norvegicus
ENSG00000188613	NANOS1	100	79.762	ENSSPUG00000002169	NANOS1	98	43.377	Sphenodon_punctatus
ENSG00000188613	NANOS1	100	61.905	ENSSPAG00000014569	NANOS1	88	34.800	Stegastes_partitus
ENSG00000188613	NANOS1	100	89.286	ENSSSCG00000040025	NANOS1	100	87.075	Sus_scrofa
ENSG00000188613	NANOS1	75	68.254	ENSTRUG00000021804	-	50	43.939	Takifugu_rubripes
ENSG00000188613	NANOS1	68	50.877	ENSTRUG00000017633	nanos2	50	49.153	Takifugu_rubripes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001558	regulation of cell growth	-	IEA	Process
GO:0001894	tissue homeostasis	-	IEA	Process
GO:0003723	RNA binding	-	IEA	Function
GO:0005515	protein binding	17047063.19168546.21800163.24736845.	IPI	Function
GO:0005737	cytoplasm	12690449.17047063.	IDA	Component
GO:0008270	zinc ion binding	-	IEA	Function
GO:0010608	posttranscriptional regulation of gene expression	25100735.	IDA	Process
GO:0010631	epithelial cell migration	17047063.	IDA	Process
GO:0016477	cell migration	18223680.	IDA	Process
GO:0017148	negative regulation of translation	24736845.	IDA	Process
GO:0030371	translation repressor activity	-	ISS	Function
GO:0048471	perinuclear region of cytoplasm	17047063.19168546.	IDA	Component
GO:0098749	cerebellar neuron development	-	IEA	Process
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	24736845.	IDA	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.