EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18223680The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression.Oncogene2008 Jun 12Bonnomet Adoi: 10.1038/sj.onc.1211035
17047063E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion.Cancer Res2006 Oct 15Strumane K-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr101190326253'UTRnovel0.2
ACCchr101190317733'UTRnovel0.31
BRCAchr101190333083'UTRnovel0.23
BRCAchr101190327013'UTRnovel0.05
CESCchr101190329673'UTRrs5430504640.32
CESCchr101190308663'UTRnovel0.28
CHOLchr101190321793'UTRnovel0.24
COADchr101190325563'UTRnovel0.41
COADchr101190309963'UTRnovel0.17
COADchr101190310793'UTRnovel0.4
COADchr10119030477Missense_MutationnovelL226F0.24zf-nanos
COADchr101190326123'UTRnovel0.17
COADchr101190333053'UTRnovel0.17
COADchr101190333863'UTRrs5510093840.2
COADchr101190322713'UTRnovel0.18
COADchr101190309103'UTRnovel0.06
COADchr101190332273'UTRnovel0.42
COADchr101190310743'UTRnovel0.21
COADchr101190315473'UTRnovel0.31
ESCAchr101190328623'UTRnovel0.75
ESCAchr101190326613'UTRnovel0.09
KIRCchr101190307883'UTRnovel0.26
KIRPchr101190314253'UTRnovel0.51
KIRPchr101190325543'UTRnovel0.23
KIRPchr101190317073'UTRnovel0.25
LIHCchr101190323083'UTRnovel0.15
LIHCchr101190314573'UTRnovel0.14
LIHCchr101190322433'UTRnovel0.42
LIHCchr101190313753'UTRnovel0.4
LIHCchr101190315643'UTRnovel0.49
LUADchr10119030579In_Frame_InsnovelH260delinsRY0.14zf-nanos
LUADchr10119030428Silentrs143230641P209P0.27
LUADchr10119030542Nonsense_MutationnovelY247*0.29zf-nanos
LUSCchr10119030587In_Frame_DelnovelY264_K269del0.11zf-nanos
READchr101190312363'UTRnovel0.18
READchr101190324643'UTRnovel0.19
READchr101190333563'UTRnovel0.13
SARCchr101190328663'UTRnovel0.24
UCECchr101190333743'UTRnovel0.08
UCECchr101190319283'UTRnovel0.1
UCECchr101190336053'UTRnovel0.57
UCECchr101190328293'UTRnovel0.05
UCECchr101190310483'UTRnovel0.24
UCECchr101190309063'UTRnovel0.43
UCECchr101190320483'UTRnovel0.23
UCECchr101190331003'UTRnovel0.47
UCECchr101190309863'UTRnovel0.34
UCECchr101190318293'UTRnovel0.16
UCECchr101190309543'UTRnovel0.48
UCECchr101190315673'UTRnovel0.36
UCECchr101190334553'UTRnovel0.27
UCECchr101190310053'UTRnovel0.44
UCECchr101190321093'UTRnovel0.48
UCECchr101190324773'UTRnovel0.52
UCECchr101190330683'UTRnovel0.36
UCECchr101190326963'UTRnovel0.39
UCECchr101190317523'UTRnovel0.61
UCECchr101190324713'UTRrs5374912660.19
UCECchr101190320713'UTRnovel0.21
UCECchr101190332403'UTRnovel0.24
UCECchr101190335533'UTRnovel0.25
UCECchr101190320483'UTRnovel0.45
UCECchr101190317433'UTRnovel0.58
UCECchr101190311763'UTRnovel0.17
UCECchr101190322003'UTRnovel0.48
UCECchr101190334233'UTRnovel0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.10.19593
CHOLDEL0.27780.048655
COADDEL0.15529.4741e-07
HNSCDEL0.16090.22646
LGGDEL0.26124.3789e-20
LIHCDEL0.24865.7505e-06
LUADDEL0.17640.0059643
LUSCDEL0.36330.038823
MESODEL0.28740.00015289
OVDEL0.30575.3759e-12
PAADDEL0.11410.169
PRADAMP0.01220.016187
READDEL0.20.014135
SKCMDEL0.55860.00079981
THYMDEL0.03250.10563
UCSDEL0.28570.1218

Survival Analysis
CancerP-value Q-value
MESO0.018

Kaplan-Meier Survival Analysis

UCS0.028

Kaplan-Meier Survival Analysis

SKCM0.0027

Kaplan-Meier Survival Analysis

BRCA0.00031

Kaplan-Meier Survival Analysis

COAD0.042

Kaplan-Meier Survival Analysis

PAAD0.0068

Kaplan-Meier Survival Analysis

BLCA0.0052

Kaplan-Meier Survival Analysis

READ0.0021

Kaplan-Meier Survival Analysis

LAML0.0028

Kaplan-Meier Survival Analysis

UCEC0.015

Kaplan-Meier Survival Analysis

GBM0.02

Kaplan-Meier Survival Analysis

LIHC0.031

Kaplan-Meier Survival Analysis

LGG0.00015

Kaplan-Meier Survival Analysis

THCA0.042

Kaplan-Meier Survival Analysis

LUAD0.00059

Kaplan-Meier Survival Analysis

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000188613 (Gene tree)
Gene ID
340719
Gene Symbol
NANOS1
Alias
NOS1|ZC2HC12A
Full Name
nanos C2HC-type zinc finger 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
4,627 bases
Position
chr10:119,029,716-119,034,342
Accession
23044
RBP type
canonical RBP
Summary
This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000345924zf-nanosPF05741.131.1e-2511
ENSP00000393275zf-nanosPF05741.131.2e-2411

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
10518502nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans.Development1999 NovSubramaniam K-
12834871nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development.Mech Dev2003 JunHaraguchi S-
24265795Protein interactions in Xenopus germ plasm RNP particles.PLoS One2013 Nov 12Nijjar Sdoi: 10.1371/journal.pone.0080077
26609159A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.J Neurosci2015 Nov 25Amadei Gdoi: 10.1523/JNEUROSCI.2172-15.2015.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000340087NANOS1-2011108-ENSP0000034592484 (aa)-Q5T9H5
ENST00000425699NANOS1-2024017-ENSP00000393275292 (aa)-Q8WY41
Gene Model
Click here to download ENSG00000188613's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000188613rs18680865010119029751?Alcoholic chronic pancreatitis28754779[1.15-1.40]1.2647022EFO_1002013
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000188613's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000188613NANOS17568.254ENSAPOG00000004421-5044.118Acanthochromis_polyacanthus
ENSG00000188613NANOS110091.765ENSAMEG00000020160-9692.135Ailuropoda_melanoleuca
ENSG00000188613NANOS19979.518ENSACAG00000027867-7595.082Anolis_carolinensis
ENSG00000188613NANOS19654.321ENSACAG00000011358-7360.345Anolis_carolinensis
ENSG00000188613NANOS110096.471ENSBTAG00000052883NANOS110078.498Bos_taurus
ENSG00000188613NANOS110097.647ENSCJAG00000044351NANOS110092.568Callithrix_jacchus
ENSG00000188613NANOS17398.361ENSCAFG00000025549-8792.857Canis_familiaris
ENSG00000188613NANOS110096.471ENSCHIG00000004298NANOS110087.119Capra_hircus
ENSG00000188613NANOS110091.765ENSCPOG00000038609NANOS110073.810Cavia_porcellus
ENSG00000188613NANOS110098.810ENSCCAG00000009164NANOS110094.178Cebus_capucinus
ENSG00000188613NANOS110098.810ENSCATG00000000994NANOS110095.222Cercocebus_atys
ENSG00000188613NANOS110091.765ENSCLAG00000005574NANOS110071.168Chinchilla_lanigera
ENSG00000188613NANOS110082.143ENSCPBG00000002172NANOS15496.970Chrysemys_picta_bellii
ENSG00000188613NANOS16852.632ENSCANG00000034930NANOS35143.182Colobus_angolensis_palliatus
ENSG00000188613NANOS110090.476ENSCGRG00001007664Nanos110072.696Cricetulus_griseus_chok1gshd
ENSG00000188613NANOS17568.254ENSDARG00000109337nanos15542.958Danio_rerio
ENSG00000188613NANOS110091.765ENSDNOG00000048482NANOS19977.397Dasypus_novemcinctus
ENSG00000188613NANOS110092.941ENSDORG00000029226Nanos110091.860Dipodomys_ordii
ENSG00000188613NANOS16877.193ENSEBUG00000002646-5475.862Eptatretus_burgeri
ENSG00000188613NANOS110095.294ENSEASG00005014466NANOS110078.498Equus_asinus_asinus
ENSG00000188613NANOS110095.294ENSECAG00000003656NANOS110076.109Equus_caballus
ENSG00000188613NANOS19288.321ENSFCAG00000040429-8988.321Felis_catus
ENSG00000188613NANOS17498.387ENSFALG00000002196NANOS19251.439Ficedula_albicollis
ENSG00000188613NANOS16349.057ENSFALG00000006160NANOS36748.214Ficedula_albicollis
ENSG00000188613NANOS17761.538ENSGMOG00000020465nanos16762.903Gadus_morhua
ENSG00000188613NANOS17370.492ENSGMOG00000015980-5570.968Gadus_morhua
ENSG00000188613NANOS16852.632ENSGMOG00000016541nanos36050.820Gadus_morhua
ENSG00000188613NANOS110078.571ENSGALG00000027980NANOS19349.123Gallus_gallus
ENSG00000188613NANOS17373.770ENSGACG00000004930-5674.194Gasterosteus_aculeatus
ENSG00000188613NANOS17568.254ENSGACG00000016692-6769.355Gasterosteus_aculeatus
ENSG00000188613NANOS110091.765ENSHGLG00000010622NANOS19177.941Heterocephalus_glaber_female
ENSG00000188613NANOS17767.692ENSIPUG00000020252nanos15141.304Ictalurus_punctatus
ENSG00000188613NANOS17568.254ENSLBEG00000016559-5143.939Labrus_bergylta
ENSG00000188613NANOS19975.904ENSLACG00000015195NANOS16253.020Latimeria_chalumnae
ENSG00000188613NANOS19956.471ENSLACG00000005166nanos15242.424Latimeria_chalumnae
ENSG00000188613NANOS19959.036ENSLOCG00000018172nanos15043.939Lepisosteus_oculatus
ENSG00000188613NANOS18079.104ENSLOCG00000018243NANOS18537.849Lepisosteus_oculatus
ENSG00000188613NANOS1100100.000ENSMMUG00000048654NANOS1100100.000Macaca_mulatta
ENSG00000188613NANOS1100100.000ENSMNEG00000022527NANOS110095.904Macaca_nemestrina
ENSG00000188613NANOS110091.667ENSMAUG00000021200Nanos110075.510Mesocricetus_auratus
ENSG00000188613NANOS110091.667ENSMOCG00000007708Nanos110074.658Microtus_ochrogaster
ENSG00000188613NANOS110078.571ENSMODG00000009319NANOS18958.423Monodelphis_domestica
ENSG00000188613NANOS110091.667MGP_CAROLIEiJ_G0023120Nanos110076.014Mus_caroli
ENSG00000188613NANOS110091.667ENSMUSG00000072437Nanos110075.254Mus_musculus
ENSG00000188613NANOS110091.667MGP_PahariEiJ_G0014608Nanos110077.211Mus_pahari
ENSG00000188613NANOS110091.667MGP_SPRETEiJ_G0024041Nanos110075.168Mus_spretus
ENSG00000188613NANOS110092.857ENSMLUG00000026243-10092.857Myotis_lucifugus
ENSG00000188613NANOS110088.095ENSNGAG00000023539Nanos17595.522Nannospalax_galili
ENSG00000188613NANOS110092.941ENSODEG00000017556NANOS110076.014Octodon_degus
ENSG00000188613NANOS110094.186ENSOGAG00000033947NANOS110084.512Otolemur_garnettii
ENSG00000188613NANOS110096.471ENSOARG00000000575-8693.458Ovis_aries
ENSG00000188613NANOS110095.294ENSPPRG00000021230NANOS110087.797Panthera_pardus
ENSG00000188613NANOS1100100.000ENSPTRG00000013314NANOS110098.630Pan_troglodytes
ENSG00000188613NANOS110098.810ENSPANG00000000318NANOS110095.563Papio_anubis
ENSG00000188613NANOS19980.723ENSPSIG00000000407-10080.723Pelodiscus_sinensis
ENSG00000188613NANOS110092.857ENSPEMG00000019116Nanos110075.085Peromyscus_maniculatus_bairdii
ENSG00000188613NANOS17571.642ENSPMAG00000010329-9661.728Petromyzon_marinus
ENSG00000188613NANOS110078.571ENSPCIG00000028425NANOS19159.364Phascolarctos_cinereus
ENSG00000188613NANOS17566.667ENSPFOG00000020533-6767.742Poecilia_formosa
ENSG00000188613NANOS16955.172ENSPLAG00000007786NANOS25053.226Poecilia_latipinna
ENSG00000188613NANOS16955.172ENSPREG00000020465nanos25353.226Poecilia_reticulata
ENSG00000188613NANOS110094.186ENSPCAG00000006942NANOS19775.940Procavia_capensis
ENSG00000188613NANOS110092.941ENSPCOG00000009467NANOS110090.816Propithecus_coquereli
ENSG00000188613NANOS110092.941ENSPVAG00000003146NANOS110085.085Pteropus_vampyrus
ENSG00000188613NANOS110091.667ENSRNOG00000025060Nanos110075.768Rattus_norvegicus
ENSG00000188613NANOS110079.762ENSSPUG00000002169NANOS19843.377Sphenodon_punctatus
ENSG00000188613NANOS110061.905ENSSPAG00000014569NANOS18834.800Stegastes_partitus
ENSG00000188613NANOS110089.286ENSSSCG00000040025NANOS110087.075Sus_scrofa
ENSG00000188613NANOS17568.254ENSTRUG00000021804-5043.939Takifugu_rubripes
ENSG00000188613NANOS16850.877ENSTRUG00000017633nanos25049.153Takifugu_rubripes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001558regulation of cell growth-IEAProcess
GO:0001894tissue homeostasis-IEAProcess
GO:0003723RNA binding-IEAFunction
GO:0005515protein binding17047063.19168546.21800163.24736845.IPIFunction
GO:0005737cytoplasm12690449.17047063.IDAComponent
GO:0008270zinc ion binding-IEAFunction
GO:0010608posttranscriptional regulation of gene expression25100735.IDAProcess
GO:0010631epithelial cell migration17047063.IDAProcess
GO:0016477cell migration18223680.IDAProcess
GO:0017148negative regulation of translation24736845.IDAProcess
GO:0030371translation repressor activity-ISSFunction
GO:0048471perinuclear region of cytoplasm17047063.19168546.IDAComponent
GO:0098749cerebellar neuron development-IEAProcess
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay24736845.IDAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us