EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15069545	Comparative analysis of thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in gastric and colorectal cancers.	Oncol Rep	2004 May	Hotta T	-
21111509	Thymidylate synthase and dihydropyrimidine dehydrogenase expression levels are associated with response to S-1 plus carboplatin in advanced non-small cell lung cancer.	Lung Cancer	2011 Jul	Takeda M	doi: 10.1016/j.lungcan.2010.10.022
16132996	Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow-up.	Int J Colorectal Dis	2006 Apr	Lassmann S	-
18004243	Dihydropyrimidine dehydrogenase activity correlates with fluorouracil sensitivity in breast cancer.	Exp Oncol	2007 Sep	Yu Z	-
27127154	Increase in Gene Expression of TYMP, DPYD and HIF1A Are Associated with Response to Preoperative Chemoradiotherapy Including S-1 or UFT for Rectal Cancer.	Anticancer Res	2016 May	Sadahiro S	-
19295264	[Clinical significance of intratumoral TS levels and DPD activity in breast cancer].	Gan To Kagaku Ryoho	2009 Mar	Miyashita M	-
19104657	Strong association of a common dihydropyrimidine dehydrogenase gene polymorphism with fluoropyrimidine-related toxicity in cancer patients.	PLoS One	2008	Gross E	doi: 10.1371/journal.pone.0004003
17699798	Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors.	Cancer Res	2007 Aug 15	Krugluger W	-
22143355	Role of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA in intrahepatic cholangiocarcinoma.	Surg Today	2012 Jan	Morine Y	doi: 10.1007/s00595-011-0054-z
19020767	Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.	Int J Mol Med	2008 Dec	Fukui Y	-
14519634	Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil.	Clin Cancer Res	2003 Sep 15	Kornmann M	-
20837458	Low thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase mRNA expression correlate with prolonged survival in resected non-small-cell lung cancer.	Clin Lung Cancer	2010 Sep 1	Grimminger PP	doi: 10.3816/CLC.2010.n.041.
22641663	Expression of dihydropyrimidine dehydrogenase, orotate phosphoribosyl transferase and thymidylate synthase in patients with primary colorectal cancer, and associations with site of first metastasis.	Anticancer Res	2012 Jun	Akagi Y	-
17417073	Thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) polymorphisms in the Korean population for prediction of 5-fluorouracil-associated toxicity.	Ther Drug Monit	2007 Apr	Cho HJ	-
22006578	TS and DPD mRNA levels on formalin-fixed paraffin-embedded specimens as predictors for distant recurrence of rectal cancer treated with preoperative chemoradiotherapy.	J Surg Oncol	2012 May	Tanaka K	doi: 10.1002/jso.22123
27461651	DPYD2A/5A/9A and UGT1A16/*28 polymorphisms in Chinese colorectal cancer patients.	J Cancer Res Ther	2016 Apr-Jun	Li GY	doi: 10.4103/0973-1482.148685.
25112781	Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer.	Gastric Cancer	2015 Jul	Sasako M	doi: 10.1007/s10120-014-0413-8
14654904	DPD activity and immunohistochemical DPD expression in human breast cancer.	Oncol Rep	2004 Jan	Horiguchi J	-
16786143	The relationship between survival and the expression of dihydropyrimidine dehydrogenase in patients with colorectal cancer.	Oncol Rep	2006 Jul	Hotta T	-
25873402	MicroRNA-494 sensitizes colon cancer cells to fluorouracil through regulation of DPYD.	IUBMB Life	2015 Mar	Chai J	doi: 10.1002/iub.1361
20809970	Promoter methylation and large intragenic rearrangements of DPYD are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients.	BMC Cancer	2010 Sep 1	Savva-Bordalo J	doi: 10.1186/1471-2407-10-470.
26372896	Changes in expression levels of ERCC1, DPYD, and VEGFA mRNA after first-line chemotherapy of metastatic colorectal cancer: results of a multicenter study.	Oncotarget	2015 Oct 20	Baba H	doi: 10.18632/oncotarget.5227.
17612628	Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression.	Biochem Cell Biol	2007 Jun	Zhang X	-
16361556	Methylation of the DPYD promoter: an alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients.	Clin Cancer Res	2005 Dec 15	Ezzeldin HH	-
20819423	Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients.	J Int Med Res	2010 May-Jun	Kristensen MH	-
14562021	Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.	Br J Cancer	2003 Oct 20	Ichikawa W	-
20714877	Relationship between the expression of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase and survival in epithelial ovarian cancer.	J Huazhong Univ Sci Technolog Med Sci	2010 Aug	Wang C	doi: 10.1007/s11596-010-0456-y
26281864	Correlation between DPYD gene variation and KRAS wild type status in colorectal cancer.	J Clin Pathol	2016 Mar	Kleist B	doi: 10.1136/jclinpath-2015-202903
15999119	Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyl transferase in prostate cancer.	Prostate Cancer Prostatic Dis	2005	Miyoshi Y	-
22490566	Polymorphisms of dihydropyrimidine dehydrogenase gene and clinical outcomes of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population.	Chin Med J (Engl)	2012 Mar	Zhang XP	-
21612699	[Expression of dihydropyrimidine dehydrogenase negatively correlated with the prognosis of pancreatic ductal adenocarcinoma].	Zhonghua Wai Ke Za Zhi	2011 Apr 1	Fang Y	-
11992400	Thymidine kinase in epithelial ovarian cancer: relationship with the other pyrimidine pathway enzymes.	Int J Cancer	2002 May 20	Fujiwaki R	-
18619742	The dihydrouracil/uracil ratio in plasma, clinical and genetic analysis for screening of dihydropyrimidine dehydrogenase deficiency in colorectal cancer patients treated with 5-fluorouracil.	Pathol Biol (Paris)	2009 Sep	Ben Fredj R	doi: 10.1016/j.patbio.2008.05.001
17203168	Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer.	Oncol Rep	2007 Feb	Salgado J	-
25066213	Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.	Mol Nutr Food Res	2014 Oct	Kelemen LE	doi: 10.1002/mnfr.201400068
16820886	Deficient expression of the DPD gene is caused by epigenetic modification in biliary tract cancer cells, and induces high sensitivity to 5-FU treatment.	Int J Oncol	2006 Aug	Sato K	-
17582310	[Pro or con the phenotyping/genotyping of patients treated by 5-Fluorouracil to prevent adverse drug reactions?].	Therapie	2007 Mar-Apr	Coriat R	-
12576451	Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.	Clin Cancer Res	2003 Feb	Ichikawa W	-
22593457	Expression levels of thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase in patients with colorectal cancer.	Anticancer Res	2012 May	Goto T	-
23401991	[Review of methods for determination of dihydropyrimidine dehydrogenase and possible application in screening previous chemotheraphy with 5-fluorouracil].	Przegl Lek	2012	Ostapowicz A	-
18347391	[Significance of pyrimidine nucleoside phosphorylase and dihydropyrimidine dehydrogenase levels to predict postoperative recurrence in primary breast cancer].	Gan To Kagaku Ryoho	2008 Mar	Tamesa M	-
19724871	Microdissection is essential for gene expression analysis of irradiated rectal cancer tissues.	Oncol Rep	2009 Oct	Inoue Y	-
11895907	Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype.	Clin Cancer Res	2002 Mar	Johnson MR	-
20647710	[Correlation between clinicopathological factors and enzymatic activity of orotate phosphoribosyl transferase (OPRT), dihydropyrimidine dehydrogenase (DPD) in esophageal cancer].	Gan To Kagaku Ryoho	2010 Jul	Takemura M	-
12851836	Clinical implications of dihydropyrimidine dehydrogenase (DPD) activity in 5-FU-based chemotherapy: mutations in the DPD gene, and DPD inhibitory fluoropyrimidines.	Int J Clin Oncol	2003 Jun	Omura K	-
15993511	The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5-fluorouracil in human lung cancer cells.	Lung Cancer	2005 Sep	Oguri T	-
28255193	The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis.	Dis Markers	2017	Zhang C	doi: 10.1155/2017/9202676
19473056	Influence of dihydropyrimidine dehydrogenase gene (DPYD) coding sequence variants on the development of fluoropyrimidine-related toxicity in patients with high-grade toxicity and patients with excellent tolerance of fluoropyrimidine-based chemotherapy.	Neoplasma	2009	Kleibl Z	-
27741011	Molecular Markers for the Prediction of Minor Response to Neoadjuvant Chemoradiation in Esophageal Cancer: Results of the Prospective Cologne Esophageal Response Prediction (CERP) Study.	Ann Surg	2016 Nov	Bollschweiler E	-
27181275	Evaluation of clinical implementation of prospective DPYD genotyping in 5-fluorouracil- or capecitabine-treated patients.	Pharmacogenomics	2016 May	Lunenburg CA	doi: 10.2217/pgs-2016-0013
28476815	Combined Analyses of hENT1, TS, and DPD Predict Outcomes of Borderline-resectable Pancreatic Cancer.	Anticancer Res	2017 May	Yabushita Y	-
27268079	Epidermal growth factor signals regulate dihydropyrimidine dehydrogenase expression in EGFR-mutated non-small-cell lung cancer.	BMC Cancer	2016 Jun 6	Tominaga T	doi: 10.1186/s12885-016-2392-0.
29065426	Dihydropyrimidine dehydrogenase pharmacogenetics for predicting fluoropyrimidine-related toxicity in the randomised, phase III adjuvant TOSCA trial in high-risk colon cancer patients.	Br J Cancer	2017 Oct 24	Ruzzo A	doi: 10.1038/bjc.2017.289
28929491	Capecitabine-based treatment of a patient with a novel DPYD genotype and complete dihydropyrimidine dehydrogenase deficiency.	Int J Cancer	2018 Jan 15	Henricks LM	doi: 10.1002/ijc.31065
29372689	DPYD genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from Slovakia.	Gen Physiol Biophys	2017 Dec	Matakova T	doi: 10.4149/gpb_2017046.
28024938	Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing.	Biochim Biophys Acta Mol Basis Dis	2017 Mar	van Kuilenburg AB	doi: 10.1016/j.bbadis.2016.12.010
30114658	Pharmacogenetic analyses of 2183 patients with advanced colorectal cancer; potential role for common dihydropyrimidine dehydrogenase variants in toxicity to chemotherapy.	Eur J Cancer	2018 Oct	Madi A	doi: 10.1016/j.ejca.2018.07.009

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr1	97920941	5'UTR	novel		0.26
ACC	chr1	97098622	Missense_Mutation	novel	S878N	0.48
ACC	chr1	97306235	Frame_Shift_Del	NA	*F707Lfs4**	0.86	Dus
BLCA	chr1	97515738	Missense_Mutation	novel	F576L	0.05
BLCA	chr1	97193209	Missense_Mutation	rs200687447	E828K	0.17
BLCA	chr1	97595120	Silent	novel	Q299Q	0.12
BLCA	chr1	97721592	Missense_Mutation	NA	D134V	0.17
BLCA	chr1	97450201	Missense_Mutation	novel	P588L	0.08
BLCA	chr1	97306220	Silent	novel	P712P	0.19
BLCA	chr1	97078949	3'UTR	novel		0.23
BLCA	chr1	97883312	Missense_Mutation	novel	K34N	0.38
BLCA	chr1	97593379	Missense_Mutation	rs201018345	A323T	0.08
BLCA	chr1	97450133	Missense_Mutation	NA	E611K	0.19
BLCA	chr1	97382450	Silent	novel	A639A	0.5
BLCA	chr1	97721626	Missense_Mutation	NA	G123C	0.39
BLCA	chr1	97595098	Missense_Mutation	novel	K307E	0.11
BLCA	chr1	97595135	Missense_Mutation	novel	F294L	0.24
BLCA	chr1	97515904	Missense_Mutation	NA	L521Q	0.14
BLCA	chr1	97573950	Silent	NA	E383E	0.38
BLCA	chr1	97573937	Missense_Mutation	novel	L388V	0.21
BLCA	chr1	97740410	Silent	novel	I101I	0.37
BLCA	chr1	97373623	Nonsense_Mutation	NA	E666*	0.31	Dus
BLCA	chr1	97549698	Silent	novel	P462P	0.21
BRCA	chr1	97883318	Silent	novel	S32S	0.09
BRCA	chr1	97593356	Silent	NA	S330S	0.33
BRCA	chr1	97720802	Intron	novel		0.15
BRCA	chr1	97595046	Splice_Site	novel	X314_splice	0.19
BRCA	chr1	97305342	Nonsense_Mutation	NA	S739*	0.3
BRCA	chr1	97079057	Silent	rs757509506	V999V	0.1
BRCA	chr1	97305353	Silent	novel	T735T	0.06
BRCA	chr1	97515870	Silent	novel	D532D	0.07
CESC	chr1	97515897	Silent	novel	L523L	0.19
CESC	chr1	97679107	Missense_Mutation	novel	F280V	0.32
CESC	chr1	97720873	Intron	novel		0.43
CESC	chr1	97079020	Nonsense_Mutation	rs761584058	E1012*	0.29
CESC	chr1	97082389	Missense_Mutation	rs763862486	E950K	0.32
CESC	chr1	97082414	Frame_Shift_Del	novel	*E942Sfs6**	0.11
CESC	chr1	97679118	Missense_Mutation	novel	Y276C	0.44
CESC	chr1	97193111	Silent	NA	Q860Q	0.12
CESC	chr1	97573952	Missense_Mutation	novel	E383K	0.4
CESC	chr1	97450142	Missense_Mutation	novel	L608V	0.61
CESC	chr1	97720815	Intron	novel		0.22
CESC	chr1	97699506	Silent	novel	S175S	0.5
CESC	chr1	97720855	Intron	novel		0.28
COAD	chr1	97234900	Silent	NA	S798S	0.15
COAD	chr1	97306235	Frame_Shift_Del	NA	*F707Lfs4**	0.27	Dus
COAD	chr1	97679126	Missense_Mutation	NA	E273D	0.12
COAD	chr1	97573950	Silent	NA	E383E	0.31
COAD	chr1	97098520	Missense_Mutation	novel	F912C	0.07
COAD	chr1	97193231	Missense_Mutation	novel	Q820H	0.28
COAD	chr1	97699457	Missense_Mutation	novel	L192F	0.3
COAD	chr1	97082458	Missense_Mutation	novel	K927E	0.25
COAD	chr1	97593379	Missense_Mutation	rs201018345	A323T	0.06
COAD	chr1	97593336	Missense_Mutation	NA	V337A	0.29
COAD	chr1	97515899	Frame_Shift_Del	novel	*L523Sfs13**	0.32
COAD	chr1	97573918	Missense_Mutation	novel	R394Q	0.24
COAD	chr1	97306235	Frame_Shift_Del	NA	*F707Lfs4**	0.34	Dus
COAD	chr1	97079145	Missense_Mutation	NA	A970D	0.23
COAD	chr1	97306282	Missense_Mutation	rs538703919	R692W	0.29	Dus
COAD	chr1	97721543	Silent	novel	I150I	0.14
COAD	chr1	97079055	Missense_Mutation	novel	D1000G	0.46
COAD	chr1	97306195	Missense_Mutation	rs145548112	A721T	0.39	Dus
COAD	chr1	97721603	Silent	NA	C130C	0.2
COAD	chr1	97082473	Splice_Region	NA		0.19
COAD	chr1	97079031	Missense_Mutation	NA	T1008K	0.1
COAD	chr1	97720701	Intron	novel		0.3
COAD	chr1	97699431	Missense_Mutation	NA	I200M	0.11
COAD	chr1	97720896	Intron	NA		0.3
COAD	chr1	97721569	Missense_Mutation	rs763623595	L142V	0.34
COAD	chr1	97305373	Missense_Mutation	NA	A729T	0.34	Dus
COAD	chr1	97720780	Intron	novel		0.07
COAD	chr1	97193169	Missense_Mutation	NA	K841I	0.26
COAD	chr1	97450071	Missense_Mutation	NA	D631E	0.26
COAD	chr1	97549703	Missense_Mutation	NA	L461I	0.25
COAD	chr1	97883365	Missense_Mutation	NA	A17T	0.36
COAD	chr1	97078965	3'UTR	novel		0.32
COAD	chr1	97828158	Missense_Mutation	NA	K63N	0.11
COAD	chr1	97515906	Missense_Mutation	novel	E520D	0.38
COAD	chr1	97549637	Missense_Mutation	rs141439344	V483I	0.22
COAD	chr1	97573760	Missense_Mutation	NA	V447L	0.32
COAD	chr1	97079073	Missense_Mutation	NA	S994N	0.13
COAD	chr1	97679174	Silent	rs754745863	C257C	0.37
DLBC	chr1	97721613	Missense_Mutation	novel	G127E	0.33
DLBC	chr1	97720687	Intron	novel		0.25
DLBC	chr1	97082448	Missense_Mutation	rs568169006	Q930R	0.4
ESCA	chr1	97193067	Splice_Site	novel	X874_splice	0.11
ESCA	chr1	97595123	Silent	rs61758443	T298T	0.14
ESCA	chr1	97306291	Missense_Mutation	novel	E689K	0.21	Dus
GBM	chr1	97382451	Missense_Mutation	novel	A639V	0.3
GBM	chr1	97920985	5'UTR	novel		0.85
GBM	chr1	97382422	Missense_Mutation	NA	D649Y	0.33	Dus
HNSC	chr1	97305285	Missense_Mutation	novel	K758R	0.58
HNSC	chr1	97515855	Missense_Mutation	novel	M537I	0.09
HNSC	chr1	97691764	Missense_Mutation	rs750687600	D239N	0.24
HNSC	chr1	97306222	Missense_Mutation	novel	P712A	0.18	Dus
HNSC	chr1	97193243	Silent	novel	C816C	0.34
HNSC	chr1	97450170	Silent	NA	P598P	0.35
HNSC	chr1	97573789	Missense_Mutation	novel	A437V	0.14
HNSC	chr1	97595156	Missense_Mutation	novel	E287D	0.11
HNSC	chr1	97740468	Missense_Mutation	novel	C82F	0.18
HNSC	chr1	97699398	Silent	NA	Y211Y	0.65
HNSC	chr1	97098492	Silent	novel	I921I	0.24
HNSC	chr1	97573766	Missense_Mutation	novel	P445S	0.24
HNSC	chr1	97234926	Missense_Mutation	novel	I790F	0.58
HNSC	chr1	97306260	Missense_Mutation	novel	R699M	0.21	Dus
HNSC	chr1	97549673	Missense_Mutation	novel	T471S	0.32
HNSC	chr1	97740426	Missense_Mutation	rs771573678	D96V	0.21
HNSC	chr1	97593289	Missense_Mutation	rs143154602	R353C	0.25
HNSC	chr1	97305318	Missense_Mutation	novel	D747V	0.26
HNSC	chr1	97306270	Missense_Mutation	novel	R696G	0.26	Dus
HNSC	chr1	97691744	Silent	novel	I245I	0.11
HNSC	chr1	97573778	Missense_Mutation	novel	V441I	0.28
KIRC	chr1	97098564	Silent	NA	L897L	0.24
KIRC	chr1	97883312	Missense_Mutation	NA	K34N	0.25
KIRP	chr1	97720861	Intron	rs187184975		0.39
KIRP	chr1	97593253	Nonsense_Mutation	NA	K365*	0.37
LGG	chr1	97078884	3'UTR	novel		0.22
LGG	chr1	97699510	Missense_Mutation	novel	P174H	0.22
LGG	chr1	97720893	Intron	novel		0.11
LGG	chr1	97721658	Missense_Mutation	novel	A112D	0.3
LGG	chr1	97082393	Missense_Mutation	novel	I948M	0.05
LIHC	chr1	97699540	Missense_Mutation	novel	K164T	0.26
LIHC	chr1	97699442	Missense_Mutation	NA	P197S	0.31
LIHC	chr1	97720690	Intron	novel		0.27
LIHC	chr1	97549637	Missense_Mutation	rs141439344	V483I	0.29
LIHC	chr1	97078874	3'UTR	novel		0.2
LIHC	chr1	97515766	Missense_Mutation	NA	G567V	0.25
LIHC	chr1	97549711	Missense_Mutation	NA	R458K	0.22
LIHC	chr1	97098497	Missense_Mutation	NA	T920A	0.25
LUAD	chr1	97549715	Missense_Mutation	NA	N457Y	0.19
LUAD	chr1	97595075	Silent	NA	A314A	0.16
LUAD	chr1	97515892	Missense_Mutation	NA	Y525C	0.35
LUAD	chr1	97373623	Nonsense_Mutation	NA	E666*	0.24	Dus
LUAD	chr1	97721552	Missense_Mutation	NA	E147D	0.22
LUAD	chr1	97515785	Nonsense_Mutation	NA	R561*	0.09
LUAD	chr1	97193091	Missense_Mutation	NA	R867L	0.21
LUAD	chr1	97079097	Missense_Mutation	novel	C986S	0.13
LUAD	chr1	97234869	Missense_Mutation	novel	G809C	0.14
LUAD	chr1	97593330	Missense_Mutation	novel	G339V	0.2
LUAD	chr1	97373634	Missense_Mutation	NA	A662V	0.32	Dus
LUAD	chr1	97699371	Silent	novel	Q220Q	0.16
LUAD	chr1	97098632	Missense_Mutation	rs201035051	K875Q	0.38
LUAD	chr1	97515851	Missense_Mutation	rs142619737	G539R	0.18
LUAD	chr1	97193098	Missense_Mutation	rs773815814	V865F	0.22
LUAD	chr1	97549601	Missense_Mutation	NA	D495N	0.18
LUAD	chr1	97593378	Missense_Mutation	NA	A323D	0.2
LUAD	chr1	97593324	Missense_Mutation	NA	G341E	0.19
LUAD	chr1	97549643	Missense_Mutation	novel	D481Y	0.22
LUAD	chr1	97691739	Missense_Mutation	novel	L247R	0.42
LUAD	chr1	97306285	Missense_Mutation	rs202212118	V691L	0.14	Dus
LUAD	chr1	97515851	Missense_Mutation	rs142619737	G539R	0.22
LUAD	chr1	97549609	Missense_Mutation	rs72549304	S492L	0.18
LUAD	chr1	97234944	Missense_Mutation	NA	A784S	0.52
LUSC	chr1	97573865	Missense_Mutation	novel	E412Q	0.32
LUSC	chr1	97082452	Missense_Mutation	novel	L929V	0.18
LUSC	chr1	97082430	Missense_Mutation	novel	G936V	0.33
LUSC	chr1	97593249	Missense_Mutation	rs752985272	G366V	0.14
LUSC	chr1	97593250	Missense_Mutation	NA	G366S	0.14
LUSC	chr1	97699401	Frame_Shift_Del	novel	*Y211Tfs16**	0.06
LUSC	chr1	97082342	Silent	NA	D965D	0.31
LUSC	chr1	97549711	Missense_Mutation	NA	R458K	0.26
LUSC	chr1	97593223	Missense_Mutation	NA	E375K	0.43
LUSC	chr1	97082430	Missense_Mutation	novel	G936A	0.19
LUSC	chr1	97699451	Missense_Mutation	novel	G194C	0.39
LUSC	chr1	97193124	Missense_Mutation	rs752228747	T856I	0.4
LUSC	chr1	97720848	Intron	novel		0.25
LUSC	chr1	97549724	Missense_Mutation	novel	I454V	0.13
LUSC	chr1	97549701	Silent	novel	L461L	0.58
LUSC	chr1	97306244	Missense_Mutation	NA	I704M	0.32	Dus
LUSC	chr1	97573759	Splice_Site	NA	X447_splice	0.28
LUSC	chr1	97593379	Missense_Mutation	NA	A323P	0.23
LUSC	chr1	97699505	Silent	NA	L176L	0.23
LUSC	chr1	97828145	Missense_Mutation	NA	G68C	0.39
LUSC	chr1	97595146	Missense_Mutation	novel	D291H	0.3
OV	chr1	97691724	Missense_Mutation	NA	G252V	0.24
OV	chr1	97373573	Silent	novel	L682L	0.13
OV	chr1	97573919	Silent	rs140602333	R394R	0.18
OV	chr1	97515773	Nonsense_Mutation	novel	E565*	0.06
OV	chr1	97828115	Nonsense_Mutation	rs776692894	R78*	0.2
OV	chr1	97450190	Missense_Mutation	rs59086055	R592W	0.19
OV	chr1	97699545	Splice_Region	NA	V162V	0.46
OV	chr1	97549558	Splice_Site	NA	X508_splice	0.27
OV	chr1	97595110	Missense_Mutation	novel	F303L	0.18
OV	chr1	97549698	Silent	NA	P462P	0.2
OV	chr1	97549651	Nonsense_Mutation	novel	*A478delinsDSGNSIGDAKS**	0.24
PAAD	chr1	97691770	Missense_Mutation	rs267598789	P237S	0.18
PAAD	chr1	97740401	Missense_Mutation	rs749699298	I104M	0.18
PAAD	chr1	97098619	Missense_Mutation	novel	F879S	0.13
PAAD	chr1	97306195	Missense_Mutation	rs145548112	A721T	0.21	Dus
PAAD	chr1	97920941	5'UTR	novel		0.5
PRAD	chr1	97098572	Missense_Mutation	NA	I895V	0.34
PRAD	chr1	97234877	Missense_Mutation	novel	L806P	0.27
READ	chr1	97883352	Missense_Mutation	rs80081766	R21Q	0.33
READ	chr1	97193091	Missense_Mutation	NA	R867L	0.36
READ	chr1	97515923	Missense_Mutation	rs148994843	V515I	0.42
READ	chr1	97079006	Silent	rs545959800	G1016G	0.39
READ	chr1	97699456	Missense_Mutation	NA	L192P	0.22
READ	chr1	97079025	Missense_Mutation	NA	P1010H	0.16
READ	chr1	97098588	Silent	NA	I889I	0.17
READ	chr1	97079128	Nonsense_Mutation	novel	E976*	0.38
READ	chr1	97305344	Silent	novel	V738V	0.29
READ	chr1	97515805	Missense_Mutation	novel	A554V	0.42
READ	chr1	97720876	Intron	novel		0.4
SARC	chr1	97691725	Missense_Mutation	novel	G252S	0.53
SARC	chr1	97828139	Nonsense_Mutation	rs141597515	R70*	0.27
SARC	chr1	97082439	Missense_Mutation	novel	G933E	0.35
SARC	chr1	97699511	Missense_Mutation	NA	P174S	0.33
SARC	chr1	97082472	Splice_Site	novel	X923_splice	0.19
SARC	chr1	97699420	Missense_Mutation	NA	S204F	0.44
SKCM	chr1	97082431	Missense_Mutation	novel	G936S	0.59
SKCM	chr1	97699379	Missense_Mutation	NA	E218K	0.35
SKCM	chr1	97593357	Missense_Mutation	rs777560627	S330L	0.3
SKCM	chr1	97699420	Missense_Mutation	NA	S204F	0.29
SKCM	chr1	97450179	Silent	novel	T595T	0.16
SKCM	chr1	97450180	Missense_Mutation	novel	T595I	0.17
SKCM	chr1	97078909	3'UTR	novel		0.13
SKCM	chr1	97450147	Missense_Mutation	NA	S606F	0.33
SKCM	chr1	97721648	Missense_Mutation	NA	M115I	0.3
SKCM	chr1	97515725	Splice_Site	NA	X580_splice	0.56
SKCM	chr1	97082392	Missense_Mutation	NA	D949N	0.36
SKCM	chr1	97699420	Missense_Mutation	NA	S204F	0.31
SKCM	chr1	97573952	Missense_Mutation	novel	E383K	0.67
SKCM	chr1	97078972	3'UTR	novel		0.41
SKCM	chr1	97721640	Missense_Mutation	novel	S118F	0.35
SKCM	chr1	97082351	Silent	rs368617815	T962T	0.39
SKCM	chr1	97078951	3'UTR	novel		0.25
SKCM	chr1	97234910	Missense_Mutation	NA	G795E	0.18
SKCM	chr1	97082443	Missense_Mutation	NA	L932F	0.15
SKCM	chr1	97573928	Silent	novel	L391L	0.17
SKCM	chr1	97573968	Missense_Mutation	NA	M377I	0.55
SKCM	chr1	97691784	Missense_Mutation	NA	P232L	0.24
SKCM	chr1	97595146	Missense_Mutation	NA	D291N	0.43
SKCM	chr1	97082392	Missense_Mutation	NA	D949N	0.54
SKCM	chr1	97234901	Missense_Mutation	novel	S798F	0.23
SKCM	chr1	97699420	Missense_Mutation	NA	S204F	0.47
SKCM	chr1	97593263	Silent	rs372369973	I361I	0.2
SKCM	chr1	97883281	Missense_Mutation	NA	P45S	0.43
SKCM	chr1	97699420	Missense_Mutation	NA	S204F	0.15
SKCM	chr1	97573856	Missense_Mutation	NA	E415K	0.38
SKCM	chr1	97699527	Silent	NA	I168I	0.35
SKCM	chr1	97305282	Missense_Mutation	rs267598786	R759Q	0.31
SKCM	chr1	97373592	Missense_Mutation	rs575853463	G676E	0.34	Dus
SKCM	chr1	97573929	Silent	NA	F390F	0.36
SKCM	chr1	97078965	3'UTR	novel		0.28
SKCM	chr1	97082428	Missense_Mutation	rs776236081	E937K	0.18
SKCM	chr1	97193140	Missense_Mutation	NA	G851R	0.32
SKCM	chr1	97573913	Missense_Mutation	NA	V396I	0.22
SKCM	chr1	97593266	Silent	NA	F360F	0.25
SKCM	chr1	97720896	Intron	NA		0.17
SKCM	chr1	97098608	Silent	NA	L883L	0.36
SKCM	chr1	97515931	Missense_Mutation	NA	G512E	0.33
SKCM	chr1	97883281	Missense_Mutation	NA	P45S	0.45
SKCM	chr1	97082344	Missense_Mutation	NA	D965N	0.2
SKCM	chr1	97234929	Missense_Mutation	rs267598785	P789S	0.41
SKCM	chr1	97373615	Missense_Mutation	NA	N668K	0.15	Dus
SKCM	chr1	97078939	3'UTR	novel		0.66
SKCM	chr1	97193106	Missense_Mutation	novel	G862E	0.64
SKCM	chr1	97193140	Missense_Mutation	NA	G851R	0.48
SKCM	chr1	97699466	Missense_Mutation	NA	K189Q	0.45
SKCM	chr1	97079013	Missense_Mutation	novel	K1014M	0.53
SKCM	chr1	97573955	Missense_Mutation	novel	E382K	0.3
SKCM	chr1	97699379	Missense_Mutation	NA	E218K	0.49
SKCM	chr1	97098588	Silent	NA	I889I	0.28
SKCM	chr1	97699412	Missense_Mutation	rs749269410	A207T	0.23
SKCM	chr1	97515747	Silent	NA	T573T	0.5
SKCM	chr1	97082439	Missense_Mutation	novel	G933E	0.5
SKCM	chr1	97082396	Missense_Mutation	novel	M947I	0.29
SKCM	chr1	97515833	Missense_Mutation	NA	P545S	0.17
SKCM	chr1	97721648	Missense_Mutation	NA	M115I	0.22
SKCM	chr1	97595154	Missense_Mutation	NA	P288L	0.44
SKCM	chr1	97573814	Silent	novel	L429L	0.46
SKCM	chr1	97721634	Missense_Mutation	rs771534236	N120S	0.42
SKCM	chr1	97306297	Missense_Mutation	NA	D687N	0.64	Dus
SKCM	chr1	97079034	Missense_Mutation	NA	R1007K	0.09
SKCM	chr1	97515793	Missense_Mutation	novel	S558L	0.14
SKCM	chr1	97699370	Missense_Mutation	NA	E221K	0.13
SKCM	chr1	97079020	Missense_Mutation	NA	E1012K	0.29
SKCM	chr1	97740427	Missense_Mutation	NA	D96N	0.48
SKCM	chr1	97193209	Missense_Mutation	rs200687447	E828K	0.47
SKCM	chr1	97699420	Missense_Mutation	NA	S204F	0.14
SKCM	chr1	97450102	Nonsense_Mutation	novel	W621*	0.39
SKCM	chr1	97740427	Missense_Mutation	NA	D96N	0.36
SKCM	chr1	97305282	Missense_Mutation	rs267598786	R759Q	0.39
SKCM	chr1	97573842	Nonsense_Mutation	NA	W419*	0.48
SKCM	chr1	97679178	Missense_Mutation	NA	I256N	0.25
SKCM	chr1	97883356	Missense_Mutation	NA	P20S	0.21
SKCM	chr1	97515784	Missense_Mutation	rs201615754	R561Q	0.73
SKCM	chr1	97699422	Silent	NA	A203A	0.29
SKCM	chr1	97699527	Silent	NA	I168I	0.37
SKCM	chr1	97234927	Silent	NA	P789P	0.34
SKCM	chr1	97573856	Missense_Mutation	NA	E415K	0.34
SKCM	chr1	97193074	Missense_Mutation	NA	D873N	0.43
SKCM	chr1	97193111	Silent	NA	Q860Q	0.4
SKCM	chr1	97699409	Nonsense_Mutation	NA	R208*	0.52
SKCM	chr1	97699361	Missense_Mutation	NA	G224S	0.11
SKCM	chr1	97306243	Missense_Mutation	NA	P705S	0.2	Dus
SKCM	chr1	97193210	Silent	rs759147254	I827I	0.56
SKCM	chr1	97078912	3'UTR	novel		0.31
SKCM	chr1	97098547	Missense_Mutation	NA	A903V	0.47
SKCM	chr1	97699469	Missense_Mutation	NA	A188P	0.18
SKCM	chr1	97193209	Missense_Mutation	rs200687447	E828K	0.17
SKCM	chr1	97515832	Missense_Mutation	NA	P545L	0.49
SKCM	chr1	97549687	Missense_Mutation	novel	P466L	0.34
SKCM	chr1	97573840	Missense_Mutation	NA	N420I	0.1
SKCM	chr1	97573784	Missense_Mutation	NA	G439S	0.16
SKCM	chr1	97193105	Silent	NA	G862G	0.32
SKCM	chr1	97082372	Silent	NA	N955N	0.18
SKCM	chr1	97699500	Silent	NA	P177P	0.11
SKCM	chr1	97721645	Silent	NA	I116I	0.49
SKCM	chr1	97305282	Missense_Mutation	rs267598786	R759Q	0.5
SKCM	chr1	97721590	Missense_Mutation	NA	L135F	0.76
SKCM	chr1	97699379	Missense_Mutation	NA	E218K	0.83
SKCM	chr1	97515734	Missense_Mutation	NA	L578F	0.37
SKCM	chr1	97593379	Missense_Mutation	rs201018345	A323T	0.33
SKCM	chr1	97593331	Missense_Mutation	novel	G339R	0.46
SKCM	chr1	97373593	Missense_Mutation	NA	G676R	0.33	Dus
SKCM	chr1	97193224	Missense_Mutation	rs752388408	D823N	0.07
SKCM	chr1	97373573	Silent	NA	L682L	0.15
SKCM	chr1	97740417	Missense_Mutation	NA	S99L	0.28
SKCM	chr1	97699420	Missense_Mutation	NA	S204F	0.32
SKCM	chr1	97450194	Silent	NA	I590I	0.36
SKCM	chr1	97691777	Silent	novel	F234F	0.49
SKCM	chr1	97883355	Missense_Mutation	NA	P20L	0.15
SKCM	chr1	97079020	Missense_Mutation	NA	E1012K	0.16
SKCM	chr1	97699493	Missense_Mutation	NA	E180K	0.17
SKCM	chr1	97740427	Missense_Mutation	NA	D96N	0.35
SKCM	chr1	97305267	Missense_Mutation	novel	G764E	0.11
SKCM	chr1	97373628	Missense_Mutation	rs749982106	A664V	0.21	Dus
SKCM	chr1	97078909	3'UTR	novel		0.67
SKCM	chr1	97234929	Missense_Mutation	rs267598785	P789S	0.26
SKCM	chr1	97079012	Silent	NA	K1014K	0.8
SKCM	chr1	97234982	Missense_Mutation	novel	R771K	0.3
SKCM	chr1	97515833	Missense_Mutation	NA	P545S	0.65
SKCM	chr1	97573780	Missense_Mutation	novel	S440L	0.67
SKCM	chr1	97595130	Missense_Mutation	rs672601284	G296D	0.32
SKCM	chr1	97595131	Missense_Mutation	novel	G296S	0.32
SKCM	chr1	97234934	Missense_Mutation	novel	G787E	0.56
SKCM	chr1	97305282	Missense_Mutation	rs267598786	R759Q	0.28
SKCM	chr1	97721595	Missense_Mutation	NA	S133F	0.27
SKCM	chr1	97306294	Missense_Mutation	NA	P688S	0.18	Dus
STAD	chr1	97306235	Frame_Shift_Del	NA	*F707Lfs4**	0.16	Dus
STAD	chr1	97082449	Nonsense_Mutation	novel	Q930*	0.16
STAD	chr1	97699484	Missense_Mutation	NA	S183P	0.28
STAD	chr1	97593288	Missense_Mutation	rs778601245	R353H	0.43
STAD	chr1	97593273	Missense_Mutation	rs573299212	R358H	0.18
STAD	chr1	97193184	Missense_Mutation	novel	A836V	0.11
STAD	chr1	97450119	Silent	novel	E615E	0.21
STAD	chr1	97450208	Missense_Mutation	novel	V586I	0.32
STAD	chr1	97699486	Frame_Shift_Ins	rs754785410	*M182Nfs3**	0.2
STAD	chr1	97593263	Silent	rs372369973	I361I	0.17
STAD	chr1	97306235	Frame_Shift_Del	NA	*F707Lfs4**	0.39	Dus
STAD	chr1	97306235	Frame_Shift_Del	NA	*F707Lfs4**	0.38	Dus
STAD	chr1	97515738	Missense_Mutation	NA	F576L	0.16
STAD	chr1	97082466	Missense_Mutation	NA	V924A	0.28
STAD	chr1	97373614	Missense_Mutation	NA	L669V	0.26	Dus
STAD	chr1	97306235	Frame_Shift_Del	NA	*F707Lfs4**	0.42	Dus
STAD	chr1	97373568	Missense_Mutation	NA	C684Y	0.11	Dus
STAD	chr1	97450120	Missense_Mutation	NA	E615A	0.11
STAD	chr1	97306235	Frame_Shift_Del	NA	*F707Lfs4**	0.15	Dus
STAD	chr1	97306235	Frame_Shift_Del	NA	*F707Lfs4**	0.26	Dus
STAD	chr1	97720923	Intron	novel		0.39
STAD	chr1	97305266	Silent	novel	G764G	0.34
STAD	chr1	97593262	Missense_Mutation	rs752020412	V362I	0.14
STAD	chr1	97515943	Splice_Site	NA	X509_splice	0.16
STAD	chr1	97098541	Missense_Mutation	NA	S905L	0.08
STAD	chr1	97450207	Missense_Mutation	NA	V586G	0.1
STAD	chr1	97306235	Frame_Shift_Del	NA	*F707Lfs4**	0.32	Dus
STAD	chr1	97593225	Missense_Mutation	NA	P374H	0.29
STAD	chr1	97305265	Missense_Mutation	novel	V765M	0.38
STAD	chr1	97691743	Nonsense_Mutation	novel	E246*	0.3
STAD	chr1	97573953	Missense_Mutation	NA	E382D	0.37
TGCT	chr1	97373576	Silent	novel	G681G	0.16
THCA	chr1	97699534	Frame_Shift_Ins	novel	*M166Tfs11**	0.07
THCA	chr1	97721582	Frame_Shift_Del	novel	*G138Vfs29**	0.09
THCA	chr1	97306181	Silent	NA	K725K	0.05
THCA	chr1	97573853	Missense_Mutation	novel	T416A	0.11
THCA	chr1	97234928	In_Frame_Ins	novel	P789delinsHAA	0.07
THCA	chr1	97234930	Missense_Mutation	novel	F788L	0.04
UCEC	chr1	97306235	Frame_Shift_Del	NA	*F707Lfs4**	0.26	Dus
UCEC	chr1	97098560	Nonsense_Mutation	NA	E899*	0.3
UCEC	chr1	97382402	Missense_Mutation	NA	K655N	0.26	Dus
UCEC	chr1	97078775	3'UTR	novel		0.09
UCEC	chr1	97098625	Missense_Mutation	NA	P877Q	0.11
UCEC	chr1	97883286	Missense_Mutation	NA	R43I	0.27
UCEC	chr1	97098497	Missense_Mutation	NA	T920A	0.4
UCEC	chr1	97306248	Missense_Mutation	novel	Q703L	0.09	Dus
UCEC	chr1	97515785	Nonsense_Mutation	NA	R561*	0.3
UCEC	chr1	97740477	Missense_Mutation	novel	C79Y	0.36
UCEC	chr1	97828133	Missense_Mutation	novel	A72T	0.36
UCEC	chr1	97883319	Missense_Mutation	rs748974194	S32L	0.29
UCEC	chr1	97721541	Missense_Mutation	NA	N151T	0.4
UCEC	chr1	97573870	Missense_Mutation	rs199646142	R410Q	0.22
UCEC	chr1	97078975	3'UTR	novel		0.39
UCEC	chr1	97079062	Missense_Mutation	rs745982505	I998V	0.38
UCEC	chr1	97082337	Missense_Mutation	novel	G967D	0.35
UCEC	chr1	97193093	Silent	rs672601274	P866P	0.2
UCEC	chr1	97573871	Missense_Mutation	rs528430685	R410W	0.36
UCEC	chr1	97679132	Silent	novel	L271L	0.32
UCEC	chr1	97082379	Missense_Mutation	NA	C953Y	0.47
UCEC	chr1	97720907	Intron	NA		0.45
UCEC	chr1	97740430	Missense_Mutation	NA	L95I	0.15
UCEC	chr1	97382390	Splice_Region	novel		0.45
UCEC	chr1	97720927	Intron	rs749542456		0.56
UCEC	chr1	97078767	3'UTR	novel		0.49
UCEC	chr1	97305321	Missense_Mutation	NA	S746Y	0.42
UCEC	chr1	97573871	Missense_Mutation	rs528430685	R410W	0.45
UCEC	chr1	97699450	Missense_Mutation	rs751841116	G194D	0.37
UCEC	chr1	97305282	Missense_Mutation	rs267598786	R759Q	0.4
UCEC	chr1	97373576	Silent	novel	G681G	0.24
UCEC	chr1	97920962	5'UTR	novel		0.36
UCEC	chr1	97078986	Missense_Mutation	rs758640823	P1023L	0.32
UCEC	chr1	97450156	Missense_Mutation	rs371258350	G603E	0.45
UCEC	chr1	97306206	Missense_Mutation	NA	I717S	0.26	Dus
UCEC	chr1	97573901	Missense_Mutation	NA	G400C	0.17
UCEC	chr1	97306282	Missense_Mutation	rs538703919	R692W	0.47	Dus
UCEC	chr1	97679101	Nonsense_Mutation	NA	G282*	0.38
UCEC	chr1	97082400	Missense_Mutation	rs753950237	A946V	0.07
UCEC	chr1	97305365	Silent	rs139543981	G731G	0.15
UCEC	chr1	97549557	Splice_Region	novel		0.2
UCEC	chr1	97593262	Missense_Mutation	rs752020412	V362I	0.31
UCEC	chr1	97549674	Missense_Mutation	novel	Q470H	0.21
UCEC	chr1	97573806	Silent	rs770549765	A431A	0.15
UCEC	chr1	97593274	Missense_Mutation	rs779557503	R358C	0.14
UCEC	chr1	97699409	Nonsense_Mutation	NA	R208*	0.19
UCEC	chr1	97549609	Missense_Mutation	rs72549304	S492L	0.41
UCEC	chr1	97549595	Missense_Mutation	novel	K497Q	0.32
UCEC	chr1	97920897	Missense_Mutation	NA	S9L	0.35
UCEC	chr1	97573806	Silent	rs770549765	A431A	0.31
UCEC	chr1	97079116	Missense_Mutation	novel	P980S	0.35
UCEC	chr1	97098633	Splice_Site	novel	X875_splice	0.34
UCEC	chr1	97720681	Intron	novel		0.5
UCEC	chr1	97720832	Intron	novel		0.42
UCEC	chr1	97593289	Missense_Mutation	rs143154602	R353C	0.25
UCEC	chr1	97699408	Missense_Mutation	rs376073289	R208Q	0.29
UCEC	chr1	97306289	Silent	novel	E689E	0.51
UCEC	chr1	97098529	Missense_Mutation	novel	R909I	0.42
UCEC	chr1	97305282	Missense_Mutation	rs267598786	R759Q	0.3
UCEC	chr1	97078884	3'UTR	novel		0.21
UCEC	chr1	97721566	Missense_Mutation	novel	Y143N	0.1
UCEC	chr1	97382462	Splice_Site	novel	X636_splice	0.38
UCEC	chr1	97720886	Intron	novel		0.23
UCEC	chr1	97306269	Missense_Mutation	rs778298325	R696H	0.35	Dus
UCEC	chr1	97679174	Silent	rs754745863	C257C	0.45
UCEC	chr1	97306235	Frame_Shift_Del	NA	*F707Lfs4**	0.12	Dus
UCEC	chr1	97079141	Missense_Mutation	NA	I971M	0.46
UCEC	chr1	97082344	Missense_Mutation	novel	D965Y	0.33
UCEC	chr1	97515784	Missense_Mutation	rs201615754	R561Q	0.43
UCEC	chr1	97549638	Silent	rs376470184	V482V	0.55
UCEC	chr1	97549739	Nonsense_Mutation	novel	E449*	0.23
UCEC	chr1	97691758	Missense_Mutation	novel	V241M	0.24
UCEC	chr1	97699399	Missense_Mutation	rs72549307	Y211C	0.3
UCEC	chr1	97828153	Missense_Mutation	rs371587702	T65M	0.33
UCEC	chr1	97593343	Missense_Mutation	rs72549306	V335M	0.51
UCEC	chr1	97573948	Missense_Mutation	novel	K384T	0.31
UCEC	chr1	97593227	Silent	novel	V373V	0.41
UCEC	chr1	97593357	Missense_Mutation	rs777560627	S330L	0.26
UCEC	chr1	97515736	Missense_Mutation	novel	S577Y	0.52
UCEC	chr1	97699409	Nonsense_Mutation	NA	R208*	0.39
UCEC	chr1	97720927	Intron	NA		0.36
UCEC	chr1	97078685	3'UTR	novel		0.2
UCEC	chr1	97305365	Silent	rs139543981	G731G	0.29
UCEC	chr1	97593255	Missense_Mutation	novel	R364I	0.28
UCEC	chr1	97450223	Missense_Mutation	novel	D581Y	0.16
UCEC	chr1	97549559	Splice_Site	novel	X508_splice	0.37
UCEC	chr1	97593262	Missense_Mutation	rs752020412	V362I	0.18
UCEC	chr1	97079104	Missense_Mutation	rs760235888	D984N	0.27
UCEC	chr1	97883368	Missense_Mutation	NA	L16M	0.35
UCEC	chr1	97450112	Missense_Mutation	novel	A618T	0.38
UCEC	chr1	97193115	Missense_Mutation	novel	H859R	0.52
UCEC	chr1	97720725	Intron	novel		0.47
UCEC	chr1	97515878	Missense_Mutation	novel	L530M	0.42
UCEC	chr1	97193165	Frame_Shift_Ins	novel	*S842Rfs4**	0.09
UCEC	chr1	97691797	Frame_Shift_Del	novel	*T228Lfs13**	0.09
UCEC	chr1	97305352	Missense_Mutation	novel	N736H	0.24
UCEC	chr1	97515785	Nonsense_Mutation	NA	R561*	0.22
UCEC	chr1	97515923	Missense_Mutation	rs148994843	V515I	0.19
UCEC	chr1	97305293	Silent	novel	G755G	0.49
UCEC	chr1	97593382	Missense_Mutation	novel	C322R	0.47
UCEC	chr1	97450077	Missense_Mutation	NA	K629N	0.37
UCEC	chr1	97921044	5'Flank	novel		0.4
UCEC	chr1	97306204	Missense_Mutation	novel	V718M	0.43	Dus
UCEC	chr1	97515781	Missense_Mutation	novel	R562K	0.5
UCEC	chr1	97721597	Silent	novel	T132T	0.18
UCEC	chr1	97828130	Missense_Mutation	novel	L73F	0.15
UCS	chr1	97549586	Missense_Mutation	novel	S500P	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2759	5.7821e-10
CESC	DEL	0.0881	0.01281
COAD	DEL	0.2395	0.00038973
DLBC	DEL	0.0833	0.0017831
MESO	DEL	0.4253	5.9874e-12
PRAD	DEL	0.0955	0.0061054
SKCM	DEL	0.2125	9.7877e-07
STAD	DEL	0.1837	0.0040659
TGCT	AMP	0.1733	0.088103

Survival Analysis

Cancer	P-value	Q-value
MESO	0.00018	Kaplan-Meier Survival Analysis
ACC	0.0022	Kaplan-Meier Survival Analysis
SKCM	0.00013	Kaplan-Meier Survival Analysis
LUSC	0.019	Kaplan-Meier Survival Analysis
BRCA	0.026	Kaplan-Meier Survival Analysis
PAAD	0.00058	Kaplan-Meier Survival Analysis
LAML	0.032	Kaplan-Meier Survival Analysis
KICH	0.045	Kaplan-Meier Survival Analysis
GBM	0.022	Kaplan-Meier Survival Analysis
LUAD	0.032	Kaplan-Meier Survival Analysis
UVM	0.011	Kaplan-Meier Survival Analysis
OV	0.045	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000188641 (Gene tree)
Gene ID: 1806
Gene Symbol: DPYD
Alias: DPD
Full Name: dihydropyrimidine dehydrogenase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 917,258 bases
Position: chr1:97,077,743-97,995,000
Accession: 3012
RBP type: canonical RBP
Summary: The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000359211	Dus	PF01207.17	1.1e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000306031	DPYD-201	1779	-	ENSP00000307107	173 (aa)	-	Q12882
ENST00000646851	DPYD-205	799	-	-	- (aa)	-	-
ENST00000474241	DPYD-204	1036	-	-	- (aa)	-	-
ENST00000370192	DPYD-202	4412	XM_005270562	ENSP00000359211	1025 (aa)	XP_005270619	Q12882
ENST00000460019	DPYD-203	551	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000188641's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00240	Pyrimidine metabolism	KEGG
hsa00410	beta-Alanine metabolism	KEGG
hsa00770	Pantothenate and CoA biosynthesis	KEGG
hsa00983	Drug metabolism - other enzymes	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000188641	Body Mass Index	3.82174696255354E-5	17903300
ENSG00000188641	Body Mass Index	9.34491536301856E-5	17903300
ENSG00000188641	Body Mass Index	3.90550385800621E-5	17903300
ENSG00000188641	Body Weight	7.75007406653866E-5	17903300
ENSG00000188641	Body Mass Index	4.07827249701877E-5	17903300
ENSG00000188641	Body Mass Index	1.49787933724885E-5	17903300
ENSG00000188641	Body Mass Index	5.60146183386526E-5	17903300
ENSG00000188641	Triglycerides	5.77060579256276E-5	17903299
ENSG00000188641	Lipids	2.82665825673754E-5	17903299
ENSG00000188641	Platelet Aggregation	2.88852579640401E-5	17903294
ENSG00000188641	Platelet Aggregation	2.76089868100783E-5	17903294
ENSG00000188641	Platelet Aggregation	1.6432518722821E-5	17903294
ENSG00000188641	Platelet Aggregation	2.76296082390217E-5	17903294
ENSG00000188641	Social Behavior	5.382e-005	-
ENSG00000188641	Personality	9.78e-005	-
ENSG00000188641	Personality	9.78e-005	-
ENSG00000188641	Hypertrophy, Left Ventricular	4.0790000E-005	-
ENSG00000188641	Hypertrophy, Left Ventricular	3.5040000E-005	-
ENSG00000188641	Platelet Function Tests	3.3800000E-006	-
ENSG00000188641	Platelet Function Tests	6.2500000E-006	-
ENSG00000188641	Platelet Function Tests	6.2500000E-006	-
ENSG00000188641	Platelet Function Tests	6.2500000E-006	-
ENSG00000188641	Platelet Function Tests	6.2500000E-006	-
ENSG00000188641	Platelet Function Tests	1.2672500E-005	-
ENSG00000188641	Platelet Function Tests	3.3097800E-005	-
ENSG00000188641	Platelet Function Tests	3.7177700E-005	-
ENSG00000188641	Platelet Function Tests	3.0147777E-006	-
ENSG00000188641	Platelet Count	9E-6	21507922
ENSG00000188641	Menarche	2E-9	25231870
ENSG00000188641	Schizophrenia	1E-7	26198764

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000188641	rs4394694	1	97905893	A	Coronary artery disease	29212778	[0.018-0.05] unit increase	0.034	EFO_0000378
ENSG00000188641	rs61789073	1	97938540	T	Autism spectrum disorder or schizophrenia	28540026	[1.08-1.17]	1.12	EFO_0000692\|EFO_0003756
ENSG00000188641	rs4378243	1	97930325	T	Educational attainment (years of education)	27225129	NR unit increase	0.017930204	EFO_0004784
ENSG00000188641	rs11165924	1	97909892	A	Menarche (age at onset)	25231870	[0.018-0.042] unit increase	0.03	EFO_0004703
ENSG00000188641	rs76869799	1	97368969	G	Schizophrenia	26198764	[NR]	1.1764705	EFO_0000692
ENSG00000188641	rs36025579	1	97337068	G	Schizophrenia	28991256	[1.03-1.07]	1.0515248	EFO_0000692
ENSG00000188641	rs6685658	1	97524780	C	Heart rate response to beta blockers (atenolol monotherapy)	29478026	[3.22-7.92] bpm decrease	5.57	EFO_0007766\|EFO_0004326
ENSG00000188641	rs78164635	1	97823025	T	Intelligence (MTAG)	29326435	[0.022-0.044] unit decrease	0.032896135	EFO_0004337
ENSG00000188641	rs78164635	1	97823025	T	Cognitive performance	30038396	[0.023-0.045] unit decrease	0.034	EFO_0008354
ENSG00000188641	rs76586805	1	97864883	T	Self-reported math ability	30038396	[0.018-0.031] unit increase	0.0245	EFO_0004875
ENSG00000188641	rs10875121	1	97951890	C	Educational attainment (MTAG)	30038396	[0.012-0.019] unit increase	0.0158	EFO_0004784
ENSG00000188641	rs6663751	1	97412887	A	Self-reported math ability (MTAG)	30038396	[0.0093-0.0195] unit increase	0.0144	EFO_0004875
ENSG00000188641	rs76586805	1	97864883	T	Self-reported math ability (MTAG)	30038396	[0.019-0.031] unit increase	0.025	EFO_0004875
ENSG00000188641	rs12047563	1	97388977	A	Highest math class taken (MTAG)	30038396	[0.0084-0.0162] unit increase	0.0123	EFO_0004875
ENSG00000188641	rs17378539	1	97743554	T	Highest math class taken (MTAG)	30038396	[0.0082-0.0168] unit increase	0.0125	EFO_0004875
ENSG00000188641	rs76586805	1	97864883	T	Highest math class taken (MTAG)	30038396	[0.019-0.03] unit increase	0.0248	EFO_0004875
ENSG00000188641	rs10747488	1	97833919	A	Feeling nervous	29500382	z score increase	5.6	EFO_0009597
ENSG00000188641	rs6703588	1	97969988	A	Feeling nervous	29500382	z score decrease	5.49	EFO_0009597
ENSG00000188641	rs11165846	1	97354111	?	Platelet count	21507922			EFO_0004309
ENSG00000188641	rs187785463	1	97686569	G	Borderline personality disorder	28632202	[1.72-2.33]	2.0263424	HP_0012076
ENSG00000188641	rs693680	1	97261527	?	DNA methylation variation (age effect)	30348214			GO_0006306
ENSG00000188641	rs11165867	1	97412512	?	Schizophrenia	29483656	[1.05-1.10]	1.0718113	EFO_0000692
ENSG00000188641	rs187951956	1	97947157	A	Educational attainment (years of education)	30038396	[0.02-0.043] unit decrease	0.0315	EFO_0004784
ENSG00000188641	rs10875121	1	97951890	C	Educational attainment (years of education)	30038396	[0.014-0.021] unit increase	0.0174	EFO_0004784
ENSG00000188641	rs4506495	1	97938678	T	Educational attainment (years of education)	30038396	[0.014-0.021] unit increase	0.0174	EFO_0004784
ENSG00000188641	rs6664489	1	97953131	G	Heel bone mineral density	30598549	[0.01-0.019] unit decrease	0.0145766	EFO_0009270
ENSG00000188641	rs75641275	1	97861577	A	Sleep duration	30531941	[0.028-0.056] SD units increase	0.042	EFO_0005271
ENSG00000188641	rs10875121	1	97951890	?	Educational attainment (years of education)	30595370			EFO_0004784
ENSG00000188641	rs75641275	1	97861577	?	Body mass index	30595370			EFO_0004340
ENSG00000188641	rs11165924	1	97909892	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000188641	rs12047910	1	97134483	?	Morning person	30595370			EFO_0008328
ENSG00000188641	rs28552810	1	97299349	A	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0051-0.0103] unit decrease	0.00771947	EFO_0006527
ENSG00000188641	rs4271249	1	97933063	T	General risk tolerance (MTAG)	30643258	[0.0043-0.0091] unit increase	0.0067	EFO_0008579
ENSG00000188641	rs36025579	1

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.