EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27708074The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity.Science2016 Sep 30Torres CMdoi: 10.1126/science.aaf1644.
12149419H1(0) histone and differentiation of dendritic cells. A molecular target for tumor-derived factors.J Leukoc Biol2002 AugGabrilovich DI-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2237805741Missense_MutationNAS66L0.43
BLCAchr2237805558Missense_MutationnovelS5F0.45
BLCAchr2237805989Missense_MutationNAK149Q0.57
BRCAchr22378065603'UTRnovel0.3
CESCchr2237805764Missense_MutationNAR74C0.44
CESCchr22378073313'UTRnovel0.08
CESCchr22378073313'UTRnovel0.47
CHOLchr22378072643'UTRnovel0.43
COADchr22378068023'UTRnovel0.42
COADchr22378073323'UTRnovel0.41
COADchr22378061923'UTRnovel0.24
COADchr22378071073'UTRnovel0.48
COADchr2237805685SilentNAR47R0.1
COADchr22378073323'UTRnovel0.24
COADchr22378073323'UTRnovel0.35
COADchr22378064073'UTRnovel0.09
COADchr22378062573'UTRnovel0.21
COADchr22378063443'UTRnovel0.31
COADchr22378073323'UTRnovel0.45
COADchr22378071093'UTRnovel0.36
ESCAchr22378051515'UTRnovel0.33
GBMchr2237805614Missense_MutationnovelD24Y0.27
HNSCchr2237806081SilentnovelV179V0.31
KIRCchr2237805967SilentNAT141T0.19
KIRCchr2237805640Silentrs151035348I32I0.17
KIRPchr22378054655'UTRnovel0.53
LIHCchr22378063193'UTRrs1882189910.52
LIHCchr2237805676Frame_Shift_InsnovelS45Ffs*180.09
LIHCchr22378064273'UTRnovel0.05
LIHCchr22378067423'UTRnovel0.7
LUADchr22378054905'UTRnovel0.3
LUADchr2237805551Missense_MutationNAE3Q0.17
LUADchr2237805984Missense_MutationnovelK147R0.14
LUSCchr22378061493'UTRrs3698270280.26
LUSCchr22378061813'UTRnovel0.15
LUSCchr2237805945Missense_MutationnovelP134L0.12
OVchr2237805886Frame_Shift_DelnovelK115Rfs*30.21
OVchr2237805639Missense_MutationnovelI32S0.11
OVchr2237805913SilentnovelA123A0.5
OVchr2237805914Missense_MutationnovelS124A0.5
PCPGchr2237805884Missense_MutationnovelI114V0.26
PRADchr2237806043Missense_MutationNAP167S0.08
READchr22378073323'UTRnovel0.32
SKCMchr2237805581Missense_MutationNAP13S0.22
SKCMchr2237805938Missense_MutationNAK132E0.71
STADchr2237806063SilentnovelP173P0.39
STADchr2237805670Silentrs758978049R42R0.27
STADchr2237805801Missense_MutationNAG86E0.4
STADchr2237806016Frame_Shift_DelNAK159Nfs*210.2
UCECchr22378063653'UTRnovel0.42
UCECchr22378061443'UTRNA0.18
UCECchr2237805751SilentNAK69K0.27
UCECchr2237805764Missense_MutationNAR74C0.32
UCECchr22378073323'UTRnovel0.4
UCECchr2237805850Missense_MutationnovelK102N0.58
UCECchr2237805707Missense_MutationnovelK55Q0.51
UCECchr22378065243'UTRnovel0.4
UCECchr22378070253'UTRnovel0.39
UCECchr2237805918Missense_MutationnovelK125T0.33
UCECchr22378073893'UTRnovel0.39
UCECchr22378068023'UTRnovel0.45
UCECchr2237805925Missense_MutationnovelK127N0.22
UCECchr22378067143'UTRnovel0.56
UCECchr22378073323'UTRnovel0.48
UCECchr22378070083'UTRnovel0.25
UCECchr22378068023'UTRnovel0.43
UCECchr22378073323'UTRnovel0.56
UCECchr2237805632Missense_MutationnovelD30Y0.47
UCECchr22378071923'UTRnovel0.42
UCECchr2237805774Missense_MutationNAT77I0.53
UCECchr2237806056Missense_MutationnovelS171F0.44
UCECchr22378073323'UTRnovel0.94
UCECchr2237805682In_Frame_DelNAR47del0.33
UCECchr22378073323'UTRnovel0.22
UCECchr22378067983'UTRnovel0.34
UCECchr22378072903'UTRnovel0.3
UCECchr22378064503'UTRnovel0.38
UCECchr22378073323'UTRnovel0.5
UCECchr22378073323'UTRnovel0.34
UCECchr22378073323'UTRnovel0.6
UCECchr22378063203'UTRnovel0.32

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
PCPGDEL0.3210.044123
THCADEL0.15630.046486
THYMDEL0.07320.063154

Survival Analysis
CancerP-value Q-value
KIRC0.025

Kaplan-Meier Survival Analysis

MESO0.0093

Kaplan-Meier Survival Analysis

ACC0.00015

Kaplan-Meier Survival Analysis

UCS0.024

Kaplan-Meier Survival Analysis

SKCM0.012

Kaplan-Meier Survival Analysis

PRAD0.023

Kaplan-Meier Survival Analysis

BRCA0.033

Kaplan-Meier Survival Analysis

ESCA0.0094

Kaplan-Meier Survival Analysis

KIRP0.00086

Kaplan-Meier Survival Analysis

PAAD0.0095

Kaplan-Meier Survival Analysis

GBM0.0049

Kaplan-Meier Survival Analysis

LGG0.0043

Kaplan-Meier Survival Analysis

THCA0.039

Kaplan-Meier Survival Analysis

LUAD0.031

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000189060 (Gene tree)
Gene ID
3005
Gene Symbol
H1F0
Alias
H10|H1FV
Full Name
H1 histone family member 0
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
2,344 bases
Position
chr22:37,805,093-37,807,436
Accession
4714
RBP type
non-canonical RBP
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
31015254The Pluripotency Regulator PRDM14 Requires Hematopoietic Regulator CBFA2T3 to Initiate Leukemia in Mice.Mol Cancer Res2019 JulTracey LJdoi: 10.1158/1541-7786.MCR-18-1327
30136864Gordon H. Dixon's trace in my personal career and the quantic jump experienced in regulatory information.Syst Biol Reprod Med2018 DecMezquita-Pla Jdoi: 10.1080/19396368.2018.1503752
6540147The transcriptional regulation of Xenopus 5s RNA genes in chromatin: the roles of active stable transcription complexes and histone H1.Cell1984 JulSchlissel MS-
2995030Events in glucocorticoid hormone action. A correlation of histone H1 variant pattern changes, hormone binding to cell nuclei, and induction of mouse mammary tumor virus RNA.Eur J Biochem1985 Oct 1Wurtz T-
9585517Histone H1 binding does not inhibit transcription of nucleosomal Xenopus laevis somatic 5S rRNA templates.Biochemistry1998 May 19Howe L-
9492295Phosphatidylinositol 4,5-bisphosphate reverses the inhibition of RNA transcription caused by histone H1.Eur J Biochem1998 Jan 15Yu H-
8636143A single high affinity binding site for histone H1 in a nucleosome containing the Xenopus borealis 5 S ribosomal RNA gene.J Biol Chem1996 Mar 22Nightingale KP-
7708492Influence of histone H1 on the in vitro replication of DNA and chromatin.Nucleic Acids Res1995 Mar 11Halmer L-
10998317Nucleolin as the earliest target molecule of autoantibodies produced in MRL/lpr lupus-prone mice.Clin Immunol2000 OctHirata D-
18258916Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes.Science2008 Feb 8Krishnakumar Rdoi: 10.1126/science.1149250.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000340857H1F0-2012344-ENSP00000344504194 (aa)-P07305
Gene Model
Click here to download ENSG00000189060's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000189060's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000189060H1F010094.845ENSMUSG00000096210H1f07396.454Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II19158276.IGIProcess
GO:0000786nucleosome-IEAComponent
GO:0000790nuclear chromatin21873635.IBAComponent
GO:0000790nuclear chromatin19882353.IDAComponent
GO:0003680AT DNA binding-IEAFunction
GO:0003690double-stranded DNA binding21873635.IBAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding21873635.IBAFunction
GO:0005515protein binding9499053.26503038.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus21383955.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005719nuclear euchromatin21873635.IBAComponent
GO:0005719nuclear euchromatin15911621.IDAComponent
GO:0005794Golgi apparatus-IDAComponent
GO:0006309apoptotic DNA fragmentation-TASProcess
GO:0006334nucleosome assembly-IEAProcess
GO:0006342chromatin silencing19158276.IGIProcess
GO:0006355regulation of transcription, DNA-templated21873635.IBAProcess
GO:0015629actin cytoskeleton-IDAComponent
GO:0016584nucleosome positioning21873635.IBAProcess
GO:0016604nuclear body21873635.IBAComponent
GO:0016604nuclear body-IDAComponent
GO:0017053transcriptional repressor complex19158276.IDAComponent
GO:0030261chromosome condensation21873635.IBAProcess
GO:0031490chromatin DNA binding15911621.IDAFunction
GO:0031492nucleosomal DNA binding21873635.IBAFunction
GO:0031936negative regulation of chromatin silencing21873635.IBAProcess
GO:0045910negative regulation of DNA recombination21873635.IBAProcess
GO:2000679positive regulation of transcription regulatory region DNA binding19158276.IMPProcess
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