EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
15998374Concordant loss of fragile gene expression early in breast cancer development.Pathol Int2005 AugGuler G-
12048684[Effects of ectogenous FHIT gene on reversing malignant phenotype of human lung adenocarcinoma cells A549].Zhonghua Yi Xue Yi Chuan Xue Za Zhi2002 JunWang Y-
12452072[Loss of fragile histidine triad expression and metastasis in breast cancer].Ai Zheng2002 JunZhao P-
16217683Loss of Fhit expression is associated with poorer survival in gastric cancer but is not an independent prognostic marker.J Cancer Res Clin Oncol2006 JanBragantini E-
17393360FHIT oncosuppressor gene expression profile in human anal cancers.Int J Biol Markers2007 Jan-MarZucchini C-
24998847FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction.Oncogene2015 May 7Wu DWdoi: 10.1038/onc.2014.184
24909176c-Myc suppresses microRNA-29b to promote tumor aggressiveness and poor outcomes in non-small cell lung cancer by targeting FHIT.Oncogene2015 Apr 16Wu DWdoi: 10.1038/onc.2014.152
19621594[Mutation and abnormal expression of FHIT gene in hypopharyngeal carcinoma].Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi2009 MarWu H-
12890991Effect of FHIT gene replacement on growth, cell cycle and apoptosis in pancreatic cancer cells.Pancreatology2003Gopalakrishnan VK-
15246872Ubc9-induced inhibition of diadenosine triphosphate hydrolase activity of the putative tumor suppressor protein Fhit.Arch Biochem Biophys2004 Aug 15Golebiowski F-
20690795Restoration of fragile histidine triad (FHIT) expression inhibits cell growth and induces apoptosis in cutaneous T-cell lymphoma cell line.Cancer Invest2010 DecSong Xdoi: 10.3109/07357900902849608
15835917Phosphorylation of the human Fhit tumor suppressor on tyrosine 114 in Escherichia coli and unexpected steady state kinetics of the phosphorylated forms.Biochemistry2005 Apr 26Garrison PN-
16699861Promoter methylation profile in gallbladder cancer.J Gastroenterol2006 MarRoa JC-
22932087Expression of Ki-67, galectin-3, fragile histidine triad, and parafibromin in malignant and benign parathyroid tumors.Chin Med J (Engl)2012 AugWang O-
18162546Replication stress induces tumor-like microdeletions in FHIT/FRA3B.Proc Natl Acad Sci U S A2008 Jan 8Durkin SG-
12419158Loss of fragile histidine triad expression in colorectal carcinoma.Zhonghua Bing Li Xue Za Zhi2002 AprZhao P-
23947369Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.Cell Commun Signal2013 Aug 15Zuo Hdoi: 10.1186/1478-811X-11-59.
11902576FRA3B and other common fragile sites: the weakest links.Nat Rev Cancer2001 DecHuebner Kdoi: 10.1038/35106058.
25098403Selective monitoring of the enzymatic activity of the tumor suppressor Fhit.Angew Chem Int Ed Engl2014 Sep 15Hacker SMdoi: 10.1002/anie.201405259
16115913The fragile histidine triad gene: a molecular link between cigarette smoking and cervical cancer.Clin Cancer Res2005 Aug 15Holschneider CH-
17137614Abnormal fragile histidine triad (Fhit) expression in invasive cervical adenocarcinoma: association with tumor aggressiveness.Hum Pathol2007 FebYoon SO-
21685375Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.Blood2011 Aug 18Roy Ddoi: 10.1182/blood-2010-12-323659
15044096Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX.Biochem Biophys Res Commun2004 Apr 16Ishii H-
15902282Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome.Leukemia2005 AugIwai M-
12627509Down-regulation of fragile histidine triad expression in prostate carcinoma.Cancer2003 Mar 15Fouts RL-
19004824Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.J Biol Chem2009 Jan 9Pichiorri Fdoi: 10.1074/jbc.M806638200
16864578Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor.J Biol Chem2006 Sep 22Semba S-
12353263Reciprocal translocations in breast tumor cell lines: cloning of a t(3;20) that targets the FHIT gene.Genes Chromosomes Cancer2002 NovPopovici C-
12057912Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma.Am J Pathol2002 JunWistuba II-
18077326The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.Proc Natl Acad Sci U S A2007 Dec 18Weiske J-
24185125FHIT, EGFR, and MSH2: possible etiopathologic, prognostic, and predictive role in non-small cell lung carcinoma in Egyptian patients.Appl Immunohistochem Mol Morphol2014 AprYounes SFdoi: 10.1097/PAI.0b013e3182988fa5.
28093273Identification of Fhit as a post-transcriptional effector of Thymidine Kinase 1 expression.Biochim Biophys Acta Gene Regul Mech2017 MarKiss DLdoi: 10.1016/j.bbagrm.2017.01.005
27773744Fhit and Wwox loss-associated genome instability: A genome caretaker one-two punch.Adv Biol Regul2017 JanSchrock MSdoi: 10.1016/j.jbior.2016.09.008
28404875Fhit, a tumor suppressor protein, induces autophagy via 14-3-3τ in non-small cell lung cancer cells.Oncotarget2017 May 9Lee TGdoi: 10.18632/oncotarget.16652.
29516675Do FHIT gene alterations play a role in human solid tumors?Asia Pac J Clin Oncol2018 OctSilveira Zavalhia Ldoi: 10.1111/ajco.12868
23969757Promoter methylation status of the FHIT gene and Fhit expression: association with HER2/neu status in breast cancer patients.Oncol Rep2013 NovJeong YJdoi: 10.3892/or.2013.2668
28639889The association between RARβ and FHIT promoter methylation and the carcinogenesis of patients with cervical carcinoma: A meta-analysis.Tumour Biol2017 JunShu Rdoi: 10.1177/1010428317709126.
12231533Two-hit inactivation of FHIT by loss of heterozygosity and hypermethylation in breast cancer.Clin Cancer Res2002 SepYang Q-
19130459Fragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2gamma expression levels correlate with basal phenotype in breast cancer.Cancer2009 Feb 15Guler Gdoi: 10.1002/cncr.24103.
24729090Abnormal FHIT protein expression may be correlated with poor prognosis in gastric cancer: a meta-analysis.Tumour Biol2014 JulWang HLdoi: 10.1007/s13277-014-1936-7
17694439Microsatellite analysis of induced sputum DNA in patients with lung cancer in heavy smokers and in healthy subjects.Exp Lung Res2007 AugCastagnaro A-
15080505Expression of the fragile histidine triad gene in normal rat tissues and human kidney cancer cell lines.Res Commun Mol Pathol Pharmacol2002Lee SH-
17328863Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells.Biochem Biophys Res Commun2007 Apr 20Deng WG-
17029211[Methylation status of FHIT gene in plasma and expression of FHIT gene in cancer tissue of cervical cancer patients].Zhonghua Yi Xue Yi Chuan Xue Za Zhi2006 OctRen CC-
15073846The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma.Cancer2004 Apr 15Guler G-
17609851Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population.J Hum Genet2007Jung HY-
15569992Inactivation of the FHIT gene favors bladder cancer development.Clin Cancer Res2004 Nov 15Vecchione A-
19267103Mutation analysis of the FHIT gene in bronchoscopic specimens from patients with suspected lung cancer.Tumori2008 Nov-DecCecener G-
23131390A clinical-biological risk stratification model for resected gastric cancer: prognostic impact of Her2, Fhit, and APC expression status.Ann Oncol2013 MarBria Edoi: 10.1093/annonc/mds506
15929169Relationship between abnormality of FHIT gene and EBV infection in gastric cancer.World J Gastroenterol2005 Jun 7Xiao YP-
23797051Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer.J Histochem Cytochem2013 SepAl-Temaimi RAdoi: 10.1369/0022155413497367
24223161Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.PLoS One2013 Nov 6Gaudio Edoi: 10.1371/journal.pone.0078610
19286306Aberration of the enzymatic activity of Fhit tumor suppressor protein enhances cancer cell death upon photodynamic therapy similarly to that driven by wild-type Fhit.Cancer Lett2009 Jul 18Ferens Bdoi: 10.1016/j.canlet.2009.02.014
23780737Genetic instability of the tumor suppressor gene FHIT in normal human cells.Genes Chromosomes Cancer2013 SepPalumbo Edoi: 10.1002/gcc.22079
18426086Aberrant FHIT transcripts in human colorectal cancers.Res Commun Mol Pathol Pharmacol2005Lee SH-
14566838Loss of FHIT protein expression is a marker of adverse evolution in good prognosis localized breast cancer.Int J Cancer2003 Dec 10Ginestier C-
27236032Expression and clinical significance of miRNAs that may be associated with the FHIT gene in breast cancer.Gene2016 Sep 30Sevinc EDdoi: 10.1016/j.gene.2016.05.033
24667261[The relationship between FHIT gene promoter methylation and lung cancer risk: a meta-analysis].Zhongguo Fei Ai Za Zhi2014 MarSun Ydoi: 10.3779/j.issn.1009-3419.2014.03.09.
16231322FHIT protein enhances paclitaxel-induced apoptosis in lung cancer cells.Int J Cancer2006 Apr 1Kim CH-
20083853Fragile histidine triad (FHIT) gene is overexpressed in colorectal cancer.J Physiol Pharmacol2009 OctWierzbicki PM-
12362975Abnormal FHIT gene transcript and c-myc and c-erbB2 amplification in breast cancer.Acta Biochim Pol2002Kowara R-
21557333FHIT gene and flanking region on chromosome 3p are subjected to extensive allelic loss in Egyptian breast cancer patients.Mol Carcinog2011 AugIsmail HMdoi: 10.1002/mc.20797
21404710[Expressions of FHIT and PTEN and their significance in prostate cancer].Zhonghua Nan Ke Xue2011 FebXiao Q-
16513840Loss of fragile histidine triad gene expression in advanced lung cancer is consequent to allelic loss at 3p14 locus and promoter methylation.Mol Cancer Res2006 FebWali A-
26796853The clinicopathological significance of FHIT hypermethylation in non-small cell lung cancer, a meta-analysis and literature review.Sci Rep2016 Jan 22Yan Wdoi: 10.1038/srep19303.
25040980Combined effects methylation of FHIT, RASSF1A and RARβ genes on non-small cell lung cancer in the Chinese population.Asian Pac J Cancer Prev2014Li W-
146602805'-CpG island methylation of the FHIT gene is associated with reduced protein expression and higher clinical stage in cervical carcinomas.Ultrastruct Pathol2003 Nov-DecWu Q-
23709347Detection of FHIT and p16 mRNA deletion in biopsy specimens obtained by bronchoscopy for the diagnosis of lung cancer.Int J Biol Markers2013 Sep 27Chen Pdoi: 10.5301/JBM.5000021.
16963412[Methylation status of the 5' CpG islands in FHIT gene in the plasma and tissues of cervical cancer patients].Yi Chuan2006 SepRen CC-
12169206MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis.J Cell Mol Med2002 Apr-JunDemopoulos K-
11891319Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines.Proc Natl Acad Sci U S A2002 Mar 19Roz L-
25422218Folate deficiency and FHIT hypermethylation and HPV 16 infection promote cervical cancerization.Asian Pac J Cancer Prev2014Bai LX-
25735361Analysis of FHIT gene methylation in egyptian breast cancer women: association with clinicopathological features.Asian Pac J Cancer Prev2015Zaki SM-
18338496Importance of novel sequence alterations in the FHIT gene on formation of breast cancer.Tumori2007 Nov-DecCecener G-
25460508DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study.Oncotarget2015 Jan 20Lin HY-
18319262Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.J Biol Chem2008 May 16Trapasso Fdoi: 10.1074/jbc.M709062200
18690840FHIT and p53 status and response to platinum-based treatment in advanced non-small cell lung cancer.Curr Cancer Drug Targets2008 AugCortinovis DL-
25401976FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis.Oncotarget2015 Feb 20Waters CE-
18953408Strong signature of natural selection within an FHIT intron implicated in prostate cancer risk.PLoS One2008Ding Ydoi: 10.1371/journal.pone.0003533
15674328Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer.Oncogene2005 Feb 24Iliopoulos D-
14719099Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer.Int J Oncol2004 FebParadiso A-
17562266[Loss of exons of FHIT gene and FHIT protein expression in Yunnan tin miners with lung cancer].Ai Zheng2007 JunRuan YH-
11788890Reduced Fhit protein expression and loss of heterozygosity at FHIT gene in tumours from smoking and asbestos-exposed lung cancer patients.Int J Oncol2002 FebPylkkanen L-
15219888Understanding the mechanisms of FHIT inactivation in cervical cancer for biomarker development.J Soc Gynecol Investig2004 JulLea JS-
15935551Frequent FHIT gene loss of heterozygosity in human papillomavirus-infected non-smoking female lung cancer in Taiwan.Cancer Lett2006 Apr 8Wang J-
21095196Mutational and promoter hypermethylation status of FHIT gene in breast cancer patients of Kashmir.Mutat Res2011 Feb 10Syeed Ndoi: 10.1016/j.mrfmmm.2010.11.001
15080495Aberrant splicing of FHIT transcripts in human gastric cancer cell lines.Res Commun Mol Pathol Pharmacol2002Lee SH-
25340791FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs.PLoS Genet2014 Oct 23Suh SSdoi: 10.1371/journal.pgen.1004652
12697969Microsatellite instability is often observed in esophageal carcinoma patients with allelic loss in the FHIT/FRA3B locus.Oncology2003Mimori K-
19418484TRAIL-induced apoptosis of FHIT-negative lung cancer cells is inhibited by FHIT re-expression.J Cell Physiol2009 AugMirandola Pdoi: 10.1002/jcp.21801.
15949315[Ectogenous fragile histidine triad gene inhibits the malignant phenotype of human lung cancer cell line A549 in vitro and in vivo].Zhonghua Jie He He Hu Xi Za Zhi2005 MayZhang LQ-
19452299Fragile histidine triad (FHIT) gene and its association with p53 protein expression in the progression of gall bladder cancer.Cancer Invest2009 AugPriya TPdoi: 10.1080/07357900802711304.
19730990Novel missense mutation in FHIT gene: interpreting the effect in HPV-mediated cervical cancer in Indian women.Mol Cell Biochem2010 FebNeyaz MKdoi: 10.1007/s11010-009-0240-0.
17548701Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans.Cancer Epidemiol Biomarkers Prev2007 JunLevin AM-
20060354Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland.Oral Oncol2010 MarDincer Ndoi: 10.1016/j.oraloncology.2009.12.003
20814237Association of 5'-CpG island hypermethylation of the FHIT gene with lung cancer in southern-central Chinese population.Cancer Biol Ther2010 Nov 15Li Wdoi: 10.4161/cbt.10.10.13231
28414756Reduction in the copy number and expression level of the recurrent human papillomavirus integration gene fragile histidine triad (FHIT) predicts the transition of cervical lesions.PLoS One2017 Apr 17Wang Ldoi: 10.1371/journal.pone.0175520
27716889Establishment of two data mining models of lung cancer screening based on three gene promoter methylations combined with telomere damage.Int J Biol Markers2017 Mar 2Wang Wdoi: 10.5301/jbm.5000232.
27572663FHIT promoter methylation status, low protein and high mRNA levels in patients with non-small cell lung cancer.Int J Oncol2016 SepCzarnecka KHdoi: 10.3892/ijo.2016.3610
29282095Impact of FHIT loss on the translation of cancer-associated mRNAs.Mol Cancer2017 Dec 28Kiss DLdoi: 10.1186/s12943-017-0749-x.
29752880The Clinical Relevance of Fragile Histidine Triad Protein (FHIT) in Patients with Bladder Cancer.Med Sci Monit2018 May 12Liu XPdoi: 10.12659/MSM.906721.
30773529Evaluation of Relationship between Occurrence of Liver Cancer and Methylation of Fragile Histidine Triad (FHIT) and P16 Genes.Med Sci Monit2019 Feb 18Bai Ydoi: 10.12659/MSM.912315.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr360014132Missense_Mutationrs766467575R42W0.45DcpS_C
BLCAchr360014107Missense_Mutationrs748948023L50P0.08DcpS_C
BLCAchr359752241SilentnovelR143R0.09
BLCAchr359752258Missense_MutationnovelE138K0.2
BLCAchr360014111Missense_MutationnovelD49N0.28DcpS_C
BRCAchr360536899Missense_MutationNAS22P0.31DcpS_C
BRCAchr360014065Missense_MutationNAR64T0.38DcpS_C
COADchr360536955Missense_MutationNAF3Y0.63
COADchr3597521253'UTRnovel0.32
COADchr359922405Missense_Mutationrs139666727V97I0.24DcpS_C
COADchr360536859Splice_Siters768812859X35_splice0.41
ESCAchr360014134Missense_MutationnovelL41P0.67DcpS_C
ESCAchr360011402Splice_SitenovelX84_splice0.28
HNSCchr360536933Missense_Mutationrs149317894I10M0.28
HNSCchr3597522213'UTRnovel0.12
LIHCchr3597521243'UTRnovel0.53
LUADchr359752259SilentnovelA137A0.09
LUADchr359922351Missense_MutationnovelE115K0.1
LUSCchr360536866Missense_MutationnovelP33S0.33DcpS_C
LUSCchr360536912SilentNAL17L0.39
LUSCchr359922363Missense_MutationnovelD111H0.14
LUSCchr360014111Missense_MutationNAD49Y0.4DcpS_C
OVchr3597522053'UTRnovel0.32
OVchr360014060Missense_Mutationrs769130211G66R0.49DcpS_C
PAADchr360014051Missense_MutationnovelV69L0.17DcpS_C
PRADchr360014143Missense_MutationNAV38A0.06DcpS_C
READchr3597520933'UTRnovel0.46
READchr360011391Missense_Mutationrs747139143E87K0.17DcpS_C
SARCchr3597521953'UTRnovel0.35
SKCMchr360536879SilentNAR28R0.32
SKCMchr359752270Missense_MutationNAE134K0.22
SKCMchr360536879SilentNAR28R0.53
SKCMchr359922392Missense_MutationnovelP101L0.38DcpS_C
SKCMchr3597522053'UTRrs7737698540.39
SKCMchr360014059Missense_MutationNAG66E0.36DcpS_C
SKCMchr360011396Missense_MutationnovelG85D0.13DcpS_C
SKCMchr360014101Missense_MutationNAP52L0.13DcpS_C
SKCMchr359752256Missense_MutationNAE138D0.25
SKCMchr360536958Missense_Mutationrs755023954S2L0.25
SKCMchr3597521913'UTRnovel0.28
SKCMchr359922403SilentNAV97V0.53
STADchr360536870SilentnovelV31V0.09
STADchr360014139Silentrs751316368C39C0.16
UCECchr360014111Missense_MutationNAD49Y0.28DcpS_C
UCECchr360014132Missense_Mutationrs766467575R42W0.63DcpS_C
UCECchr3612006265'UTRnovel0.27
UCECchr360014061Silentrs372632734V65V0.21
UCECchr3612006255'UTRnovel0.25
UCECchr3597521363'UTRnovel0.22
UCECchr360014074Missense_Mutationrs148747004T61M0.38DcpS_C
UCECchr359922371Missense_MutationnovelH108R0.32
UCECchr360011383SilentnovelG89G0.21
UCECchr359752254Missense_Mutationrs371000765A139V0.21
UCECchr360536893Missense_Mutationrs372120945A24T0.18DcpS_C
UCECchr3597520593'UTRnovel0.14
UCECchr3597521203'UTRnovel0.24

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.24759.7528e-15
CESCDEL0.43391.8623e-09
CHOLDEL0.750.016387
COADDEL0.22394.0204e-33
LUADDEL0.32950.0021265
PAADDEL0.19020.030662
SARCDEL0.19460.0034746
SKCMDEL0.14440.13887
TGCTAMP0.16670.23596
THYMDEL0.08940.037527
UCECDEL0.13366.3915e-08
UCSDEL0.55364.5515e-05
UVMDEL0.53750.09134

Survival Analysis
CancerP-value Q-value
THYM0.037

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

ACC0.00015

Kaplan-Meier Survival Analysis

HNSC0.013

Kaplan-Meier Survival Analysis

SKCM0.03

Kaplan-Meier Survival Analysis

PRAD0.041

Kaplan-Meier Survival Analysis

LUSC0.03

Kaplan-Meier Survival Analysis

BRCA0.0048

Kaplan-Meier Survival Analysis

KIRP0.0025

Kaplan-Meier Survival Analysis

PCPG0.021

Kaplan-Meier Survival Analysis

BLCA0.026

Kaplan-Meier Survival Analysis

UCEC0.047

Kaplan-Meier Survival Analysis

LUAD0.018

Kaplan-Meier Survival Analysis

UVM0.0085

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000189283 (Gene tree)
Gene ID
2272
Gene Symbol
FHIT
Alias
FRA3B|AP3Aase
Full Name
fragile histidine triad
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
1,503,873 bases
Position
chr3:59,747,587-61,251,459
Accession
3701
RBP type
canonical RBP
Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000417480DcpS_CPF11969.82.1e-0611
ENSP00000417557DcpS_CPF11969.82.1e-0611
ENSP00000418582DcpS_CPF11969.82.1e-0611
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000492590FHIT-2081081XM_017005883ENSP00000418582147 (aa)XP_016861372P49789
ENST00000465330FHIT-202253--- (aa)--
ENST00000341848FHIT-201174-ENSP0000034208758 (aa)-A0A0A0MRB0
ENST00000488467FHIT-206601-ENSP0000041859678 (aa)-E9PBZ0
ENST00000468189FHIT-2041634XM_017005880ENSP00000417480147 (aa)XP_016861369P49789
ENST00000490952FHIT-2071720--- (aa)--
ENST00000466788FHIT-2033063NR_135491-- (aa)--
ENST00000476844FHIT-2051033-ENSP00000417557147 (aa)-P49789
Gene Model
Click here to download ENSG00000189283's gene model file
Pathways
Pathway IDPathway NameSource
hsa00230Purine metabolismKEGG
hsa05222Small cell lung cancerKEGG
hsa05223Non-small cell lung cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000189283Respiratory Function Tests1.63726832069856E-1017903307
ENSG00000189283Sleep1.86055357988859E-517903308
ENSG00000189283Sleep5.49352541059896E-617903308
ENSG00000189283Sleep1.11283815250505E-517903308
ENSG00000189283Body Mass Index2.53236272869172E-617903300
ENSG00000189283Body Mass Index3.74443613919476E-717903300
ENSG00000189283Body Weight8.70052763863913E-917903300
ENSG00000189283Body Weight7.2515516712443E-717903300
ENSG00000189283Body Weights and Measures6.64599416816817E-817903300
ENSG00000189283Body Mass Index2.20928492346421E-617903300
ENSG00000189283Body Weight6.67395575574214E-617903300
ENSG00000189283Cholesterol, LDL1.93077421409446E-917903299
ENSG00000189283Cholesterol, LDL2.28551705880493E-517903299
ENSG00000189283Cholesterol, LDL3.47305821472081E-517903299
ENSG00000189283Cholesterol, LDL3.45052861150386E-617903299
ENSG00000189283Cholesterol, LDL1.90735841276712E-617903299
ENSG00000189283Cholesterol, LDL6.63729425331994E-617903299
ENSG00000189283Cholesterol, LDL6.98976279678298E-617903299
ENSG00000189283Fibrinogen7.58738768995536E-817903294
ENSG00000189283Glomerular Filtration Rate1.15512639121322E-717903292
ENSG00000189283Creatinine1.33321366701441E-517903292
ENSG00000189283Blood Pressure8.34543393439189E-817903302
ENSG00000189283Electrocardiography8.18219302516354E-517903302
ENSG00000189283Mental Competency5.29972326537287E-517903295
ENSG00000189283Schizophrenia9.8E-5-
ENSG00000189283Myocardial Infarction3.9439308E-004-
ENSG00000189283Prostatic Neoplasms3.9520000E-00518264096
ENSG00000189283Heart Failure7.3567272E-004-
ENSG00000189283Heart Failure6.8380688E-004-
ENSG00000189283Stroke6.7366618E-00419369658
ENSG00000189283Alcoholism2.13E-05-
ENSG00000189283Alcoholism3.67E-05-
ENSG00000189283Alcoholism3.4E-05-
ENSG00000189283Creatinine4.889e-005-
ENSG00000189283Altruism4.496e-005-
ENSG00000189283Muscle, Skeletal7.8870000E-005-
ENSG00000189283Obesity5.7700000E-005-
ENSG00000189283Waist Circumference3.9210000E-005-
ENSG00000189283Coronary Artery Disease9.0450000E-005-
ENSG00000189283Blood Pressure4.1710000E-005-
ENSG00000189283Blood Pressure3.9260000E-005-
ENSG00000189283Hypertrophy, Left Ventricular9.7590000E-005-
ENSG00000189283Cholesterol, LDL6.6920000E-006-
ENSG00000189283Cholesterol5.4900000E-005-
ENSG00000189283Lipoprotein(a)6.3820000E-005-
ENSG00000189283Lipids2.4980000E-005-
ENSG00000189283Cholesterol5.6140000E-005-
ENSG00000189283Albumins4.5080000E-005-
ENSG00000189283Erythrocyte Count9.9610000E-005-
ENSG00000189283Erythrocyte Count4.4260000E-005-
ENSG00000189283Fetal Hemoglobin1.8700000E-00620018918
ENSG00000189283Platelet Function Tests4.4700000E-006-
ENSG00000189283Platelet Function Tests2.8590814E-006-
ENSG00000189283Platelet Function Tests7.2828860E-006-
ENSG00000189283Platelet Function Tests8.0528946E-006-
ENSG00000189283Platelet Function Tests8.5686678E-006-
ENSG00000189283Platelet Function Tests1.6533146E-006-
ENSG00000189283Platelet Function Tests9.2349175E-006-
ENSG00000189283Platelet Function Tests1.7673226E-006-
ENSG00000189283Platelet Function Tests1.6156600E-005-
ENSG00000189283Platelet Function Tests8.8780901E-006-
ENSG00000189283Platelet Function Tests3.5598600E-005-
ENSG00000189283Coronary Artery Disease8.5110000E-005-
ENSG00000189283Coronary Artery Disease8.5110000E-005-
ENSG00000189283Child Development Disorders, Pervasive7.6034000E-006-
ENSG00000189283Child Development Disorders, Pervasive1.2020000E-005-
ENSG00000189283Child Development Disorders, Pervasive7.3102000E-006-
ENSG00000189283Child Development Disorders, Pervasive3.7676000E-006-
ENSG00000189283Child Development Disorders, Pervasive2.5886000E-006-
ENSG00000189283Child Development Disorders, Pervasive1.7947000E-005-
ENSG00000189283Child Development Disorders, Pervasive4.3000000E-005-
ENSG00000189283Interleukin-105.7630000E-005-
ENSG00000189283Hydrocortisone4.4730000E-007-
ENSG00000189283Dehydroepiandrosterone7.5250000E-007-
ENSG00000189283Testosterone1.9640000E-005-
ENSG00000189283Testosterone4.4030000E-005-
ENSG00000189283Folic Acid5.9440000E-005-
ENSG00000189283Lutein1.4360000E-005-
ENSG00000189283Lutein2.4420000E-005-
ENSG00000189283Lip1E-727560520
ENSG00000189283Orofacial Cleft 17E-622419666
ENSG00000189283Schizophrenia5E-826198764
ENSG00000189283Attention Deficit Disorder with Hyperactivity8E-618821565
ENSG00000189283Autosomal dominant compelling helio ophthalmic outburst syndrome2E-3627182965
ENSG00000189283Asperger Syndrome4E-621182207
ENSG00000189283Body Mass Index3E-625673413
ENSG00000189283Pancreatitis8E-627114598
ENSG00000189283Precursor Cell Lymphoblastic Leukemia-Lymphoma8E-627114598
ENSG00000189283Bronchopulmonary Dysplasia3E-623897914
ENSG00000189283Drug Resistance2E-622952603
ENSG00000189283Myopia, Degenerative3E-623049088
ENSG00000189283Antidepressive Agents2E-622760553
ENSG00000189283Dental Caries5E-623470693
ENSG00000189283Body Mass Index3E-725673413
ENSG00000189283Body Mass Index1E-1025673413
ENSG00000189283Aorta8E-621223598
ENSG00000189283Blood Pressure8E-724954895
ENSG00000189283Breast2E-622747683
ENSG00000189283Breast Neoplasms2E-622747683
ENSG00000189283Cognition6E-625644384
ENSG00000189283Body Mass Index2E-1025673413
ENSG00000189283Anticonvulsants7E-722379998
ENSG00000189283Methadone6E-628115739
ENSG00000189283Opioid-Related Disorders6E-628115739
ENSG00000189283Depressive Disorder4E-620125088
ENSG00000189283Depressive Disorder7E-1028049566
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000189283rs1554600361172101?Intracranial aneurysm295312793.8619583EFO_0003870
ENSG00000189283rs1353545360302116CAutism spectrum disorder or schizophrenia28540026[1.04-1.08]1.06EFO_0000692|EFO_0003756
ENSG00000189283rs6782531361009928GBlood pressure24954895[0.58-1.36] mmHg decrease0.97EFO_0006335
ENSG00000189283rs80171647360522607?Response to amphetamines22952603GO_0042493
ENSG00000189283rs11707813361195644CLip morphology27560520[0.23-0.56] unit increase0.3952EFO_0007845
ENSG00000189283rs9849262360951377TAsparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time)27114598[0.81-1.99]1.4EFO_1001507|EFO_0000220
ENSG00000189283rs1353545360302116CSchizophrenia26198764[NR]1.06EFO_0000692
ENSG00000189283rs931317359943125?Myopia (pathological)23049088[NR]EFO_0004207
ENSG00000189283rs9311745360016099CPit-and-Fissure caries23470693[NR] unit increase2.9914EFO_0006338
ENSG00000189283rs11919041360777523TBreast size22747683[0.049-0.115] cup size decrease0.082EFO_0004884
ENSG00000189283rs4502542359935294TResponse to citalopram treatment22760553GO_0036276
ENSG00000189283rs9877396361141532Bronchopulmonary dysplasia23897914[NR]2Orphanet_70589
ENSG00000189283rs6791644360785375?Attention deficit hyperactivity disorder18821565EFO_0003888
ENSG00000189283rs2365389361250788TBody mass index28892062[0.015-0.027] kg/m2 decrease0.021EFO_0004340
ENSG00000189283rs13074132360335351TSchizophrenia28991256[1.03-1.07]1.052EFO_0000692
ENSG00000189283rs1353545360302116CSchizophrenia28991256[1.04-1.08]1.057EFO_0000692
ENSG00000189283rs138741635360942161AMajor coronary event in cardiovascular disease (time to event) (darapladib treatment interaction)28753643EFO_0008395|EFO_0005672|EFO_0001645|EFO_0006919
ENSG00000189283rs9833533360582520?Lung function (maximal voluntary ventilation)29095316unit increase6.68EFO_0008431|EFO_0003892
ENSG00000189283rs56334439360118301?Myringotomy28928442[0.098-0.222] unit increase0.1601EFO_0007904
ENSG00000189283rs49413359771758?Colonoscopy-negative controls vs population controls29228715[NR]1.405EFO_0008460
ENSG00000189283rs2736752360831661TEducational attainment (MTAG)30038396[0.006-0.0122] unit increase0.0091EFO_0004784
ENSG00000189283rs113436108360018183GCTACK levels27989323[0.31-0.74] SD units increase0.5249EFO_0008082
ENSG00000189283rs138741635360942161AMajor coronary event in placebo-treated cardiovascular disease (time to event)28753643[1.59-2.56]2.02EFO_0005672|EFO_0001645|EFO_0006919|EFO_0008344
ENSG00000189283rs114685959360851944AMethadone dose in opioid dependence28115739[0.43-1.09] unit increase0.7616EFO_0005611|EFO_0007907
ENSG00000189283rs10510837360304113?Asperger disorder21182207EFO_0003757
ENSG00000189283rs1825630359917075?Aortic root size21223598[0.053-0.136] cm increase0.0946EFO_0005037
ENSG00000189283rs10510829360137795?Adverse response to lamotrigine and phenytoin22379998GO_0036277
ENSG00000189283rs212016359995799?Orofacial clefts22419666[1.89-1.27]1.54Orphanet_139039
ENSG00000189283rs2365389361250788CBody mass index in physically active individuals28448500[0.021-0.037] kg/m2 increase0.0288EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788?Body mass index (joint analysis main effects and physical activity interaction)28448500EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788?Body mass index (joint analysis main effects and physical activity interaction)28448500EFO_0008002|EFO_0004340
ENSG00000189283rs9825823361096480?Depressive symptom measurement or major depressive disorder28049566Z score increase6.2EFO_0003761|EFO_0007006
ENSG00000189283rs2365389361250788TBMI (adjusted for smoking behaviour)28443625[0.022-0.042] kg/m2 decrease0.0319EFO_0004318|EFO_0004340
ENSG00000189283rs2365389361250788TBMI (adjusted for smoking behaviour)28443625[0.02-0.033] kg/m2 decrease0.0266EFO_0004318|EFO_0004340
ENSG00000189283rs2365389361250788TBMI (adjusted for smoking behaviour)28443625[0.014-0.031] kg/m2 decrease0.0225EFO_0004318|EFO_0004340
ENSG00000189283rs2365389361250788TBody mass index (joint analysis main effects and smoking interaction)28443625EFO_0004318|EFO_0004340
ENSG00000189283rs2365389361250788TBody mass index (joint analysis main effects and smoking interaction)28443625EFO_0004318|EFO_0004340
ENSG00000189283rs2365389361250788TBody mass index (joint analysis main effects and smoking interaction)28443625EFO_0004318|EFO_0004340
ENSG00000189283rs2365389361250788TBMI in smokers28443625[0.026-0.064] kg/m2 decrease0.0453EFO_0004318|EFO_0004340
ENSG00000189283rs2365389361250788TBMI in smokers28443625[0.026-0.054] kg/m2 decrease0.0396EFO_0004318|EFO_0004340
ENSG00000189283rs2365389361250788TBMI in non-smokers28443625[0.025-0.047] kg/m2 decrease0.0359EFO_0004340
ENSG00000189283rs2365389361250788TBMI in non-smokers28443625[0.018-0.033] kg/m2 decrease0.0252EFO_0004340
ENSG00000189283rs2365389361250788CBody mass index28448500[0.021-0.036] kg/m2 increase0.0283EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788CBody mass index28448500[0.024-0.046] kg/m2 increase0.0349EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788CBody mass index28448500[0.021-0.036] kg/m2 increase0.0284EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788CBody mass index28448500[0.013-0.032] kg/m2 increase0.0225EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788CBody mass index28448500[0.024-0.045] kg/m2 increase0.0346EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788CBody mass index28448500[0.014-0.032] kg/m2 increase0.023EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788CBody mass index in physically active individuals28448500[0.015-0.036] kg/m2 increase0.0256EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788CBody mass index in physically active individuals28448500[0.021-0.037] kg/m2 increase0.0291EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788CBody mass index in physically active individuals28448500[0.02-0.044] kg/m2 increase0.0323EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788CBody mass index in physically active individuals28448500[0.016-0.036] kg/m2 increase0.0258EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788?Body mass index (joint analysis main effects and physical activity interaction)28448500EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788?Body mass index (joint analysis main effects and physical activity interaction)28448500EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788?Body mass index (joint analysis main effects and physical activity interaction)28448500EFO_0008002|EFO_0004340
ENSG00000189283rs2365389361250788?Body mass index (joint analysis main effects and physical activity interaction)28448500EFO_0008002|EFO_0004340
ENSG00000189283rs633798359876145?Photic sneeze reflex27182965[1.123-1.172]1.147EFO_0007887
ENSG00000189283rs13100563360076299?Cognitive function25644384[0.022-0.056] unit decrease0.0393EFO_0004337
ENSG00000189283rs2365389361250788TBody mass index26426971unit decrease0.019783955EFO_0004340
ENSG00000189283rs2365389361250788CBody mass index30108127[NR] unit increase0.02EFO_0004340
ENSG00000189283rs2365389361250788CBody mass index26961502[0.021-0.037] unit increase0.029EFO_0004340
ENSG00000189283rs11922368360882566CBlood protein levels30072576[0.11-0.21] unit decrease0.158EFO_0007937
ENSG00000189283rs2736752360831661TEducational attainment (years of education)30038396[0.0062-0.0128] unit increase0.0095EFO_0004784
ENSG00000189283rs11920657359962844?Adolescent idiopathic scoliosis30019117EFO_0005423
ENSG00000189283rs1966136361167905ABroad depression or schizophrenia30626913EFO_0003761|EFO_0000692
ENSG00000189283rs2736750360831247AEducational attainment (years of education)30038396[0.0064-0.013] unit increase0.0097EFO_0004784
ENSG00000189283rs12493585360180162?DNA methylation variation (age effect)30348214GO_0006306
ENSG00000189283rs141954845361207237ADepression30718901[1.014-1.022]1.018EFO_0003761
ENSG00000189283rs3915074361219238?Fat-free mass30593698[0.092-0.196] unit decrease0.14369EFO_0004995
ENSG00000189283rs1353545360302116CSchizophrenia30285260[1.04-1.08]1.062EFO_0000692
ENSG00000189283rs1353545360302116CSchizophrenia30285260[1.04-1.09]1.064EFO_0000692
ENSG00000189283rs3772458359953647TSmoking initiation (ever regular vs never regular) (MTAG)30643251[0.0044-0.0087] unit decrease0.00651948EFO_0006527
ENSG00000189283rs412104360452950GSmoking initiation (ever regular vs never regular) (MTAG)30643251[0.0054-0.0097] unit increase0.00755044EFO_0006527
ENSG00000189283rs2366964359944946CMetastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event)30738427[11.81-143.66]41.19EFO_0007675|EFO_1001480|EFO_0008336
ENSG00000189283rs7640107359980430TSmoking initiation (ever regular vs never regular)30643251[0.0091-0.0192] unit decrease0.014186049EFO_0006527
ENSG00000189283rs2734390360473558GSmoking initiation (ever regular vs never regular)30643251[0.0096-0.0199] unit increase0.014770906EFO_0006527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000189283's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000189283FHIT10077.586ENSAPOG00000017471FHIT7779.091Acanthochromis_polyacanthus
ENSG00000189283FHIT9980.519ENSAOCG00000015080FHIT9580.556Amphiprion_ocellaris
ENSG00000189283FHIT9979.221ENSAPEG00000024091fhit9779.861Amphiprion_percula
ENSG00000189283FHIT9981.818ENSATEG00000000759fhit8479.861Anabas_testudineus
ENSG00000189283FHIT10097.436ENSANAG00000027270FHIT10095.973Aotus_nancymaae
ENSG00000189283FHIT9980.519ENSACLG00000026924fhit9779.167Astatotilapia_calliptera
ENSG00000189283FHIT10091.026ENSBTAG00000014418FHIT10089.262Bos_taurus
ENSG00000189283FHIT10096.154ENSCJAG00000019708FHIT10093.960Callithrix_jacchus
ENSG00000189283FHIT10096.154ENSTSYG00000034306-10093.960Carlito_syrichta
ENSG00000189283FHIT10093.590ENSCPOG00000014924FHIT9990.604Cavia_porcellus
ENSG00000189283FHIT10098.718ENSCCAG00000034976FHIT10095.302Cebus_capucinus
ENSG00000189283FHIT10097.436ENSCATG00000036063FHIT10094.631Cercocebus_atys
ENSG00000189283FHIT10096.154ENSCHOG00000004155FHIT10089.655Choloepus_hoffmanni
ENSG00000189283FHIT9761.842ENSCING00000013269-9457.639Ciona_intestinalis
ENSG00000189283FHIT10097.436ENSCANG00000031611FHIT10093.960Colobus_angolensis_palliatus
ENSG00000189283FHIT10094.872ENSCGRG00001000886Fhit9991.275Cricetulus_griseus_chok1gshd
ENSG00000189283FHIT9980.519ENSCSEG00000007690fhit9777.027Cynoglossus_semilaevis
ENSG00000189283FHIT9981.818ENSCSEG00000003468-9777.703Cynoglossus_semilaevis
ENSG00000189283FHIT9980.519ENSDARG00000078195fhit9876.871Danio_rerio
ENSG00000189283FHIT10094.872ENSDORG00000007571Fhit9993.960Dipodomys_ordii
ENSG00000189283FHIT9963.946ENSEBUG00000003924fhit8463.946Eptatretus_burgeri
ENSG00000189283FHIT9981.818ENSELUG00000008502fhit9577.778Esox_lucius
ENSG00000189283FHIT10094.872ENSFCAG00000033312FHIT10091.275Felis_catus
ENSG00000189283FHIT10087.931ENSFALG00000013210FHIT9981.633Ficedula_albicollis
ENSG00000189283FHIT9784.211ENSGALG00000007172FHIT9880.000Gallus_gallus
ENSG00000189283FHIT10098.276ENSGGOG00000042949FHIT10097.279Gorilla_gorilla
ENSG00000189283FHIT10091.026ENSHGLG00000004547FHIT9989.933Heterocephalus_glaber_female
ENSG00000189283FHIT9980.519ENSHCOG00000000541fhit9579.167Hippocampus_comes
ENSG00000189283FHIT10077.586ENSIPUG00000023729fhit9875.510Ictalurus_punctatus
ENSG00000189283FHIT10094.872ENSSTOG00000029715FHIT9993.960Ictidomys_tridecemlineatus
ENSG00000189283FHIT9983.117ENSLBEG00000028526fhit9581.250Labrus_bergylta
ENSG00000189283FHIT10097.436ENSMFAG00000040773FHIT10094.631Macaca_fascicularis
ENSG00000189283FHIT10097.436ENSMMUG00000012832FHIT10094.631Macaca_mulatta
ENSG00000189283FHIT10097.436ENSMNEG00000040755FHIT10094.631Macaca_nemestrina
ENSG00000189283FHIT10096.154ENSMLEG00000032123FHIT10093.289Mandrillus_leucophaeus
ENSG00000189283FHIT9980.519ENSMZEG00005005808fhit9779.167Maylandia_zebra
ENSG00000189283FHIT10094.872ENSMAUG00000008107Fhit10094.355Mesocricetus_auratus
ENSG00000189283FHIT10093.590ENSMICG00000043473-8691.892Microcebus_murinus
ENSG00000189283FHIT10093.590ENSMOCG00000002096Fhit9990.604Microtus_ochrogaster
ENSG00000189283FHIT10093.590MGP_CAROLIEiJ_G0018948Fhit10091.129Mus_caroli
ENSG00000189283FHIT10093.590ENSMUSG00000060579Fhit10095.000Mus_musculus
ENSG00000189283FHIT10094.872MGP_PahariEiJ_G0029963Fhit10094.309Mus_pahari
ENSG00000189283FHIT10093.590MGP_SPRETEiJ_G0019825Fhit10091.935Mus_spretus
ENSG00000189283FHIT10094.872ENSMLUG00000028904-10089.933Myotis_lucifugus
ENSG00000189283FHIT10093.590ENSNGAG00000011060Fhit9991.946Nannospalax_galili
ENSG00000189283FHIT10093.103ENSNLEG00000033239FHIT9992.617Nomascus_leucogenys
ENSG00000189283FHIT10087.179ENSMEUG00000000830FHIT10085.345Notamacropus_eugenii
ENSG00000189283FHIT9793.421ENSOPRG00000006562FHIT9891.228Ochotona_princeps
ENSG00000189283FHIT10089.655ENSODEG00000005813-9987.586Octodon_degus
ENSG00000189283FHIT10089.744ENSODEG00000019420-10089.262Octodon_degus
ENSG00000189283FHIT9981.818ENSONIG00000003104fhit9779.861Oreochromis_niloticus
ENSG00000189283FHIT10092.308ENSOGAG00000027462-10091.275Otolemur_garnettii
ENSG00000189283FHIT10094.872ENSPPRG00000023211FHIT10091.275Panthera_pardus
ENSG00000189283FHIT10094.872ENSPTIG00000006722FHIT10091.275Panthera_tigris_altaica
ENSG00000189283FHIT10098.718ENSPTRG00000015065FHIT10098.639Pan_troglodytes
ENSG00000189283FHIT10097.436ENSPANG00000018461FHIT10094.631Papio_anubis
ENSG00000189283FHIT9977.922ENSPKIG00000023792fhit9575.694Paramormyrops_kingsleyae
ENSG00000189283FHIT10086.207ENSPSIG00000007319FHIT10082.456Pelodiscus_sinensis
ENSG00000189283FHIT9981.818ENSPMGG00000017632fhit9578.322Periophthalmus_magnuspinnatus
ENSG00000189283FHIT10094.872ENSPEMG00000014589Fhit9991.275Peromyscus_maniculatus_bairdii
ENSG00000189283FHIT10097.436ENSPPYG00000013753FHIT10097.279Pongo_abelii
ENSG00000189283FHIT10093.590ENSPCOG00000010600-10093.243Propithecus_coquereli
ENSG00000189283FHIT10092.308ENSPVAG00000016009FHIT10089.933Pteropus_vampyrus
ENSG00000189283FHIT10079.310ENSPNAG00000002483fhit9878.231Pygocentrus_nattereri
ENSG00000189283FHIT10098.718ENSRBIG00000024516FHIT10094.631Rhinopithecus_bieti
ENSG00000189283FHIT10098.718ENSRROG00000002797FHIT10094.631Rhinopithecus_roxellana
ENSG00000189283FHIT10097.436ENSSBOG00000028228FHIT10095.973Saimiri_boliviensis_boliviensis
ENSG00000189283FHIT9981.818ENSSFOG00015018887fhit9679.861Scleropages_formosus
ENSG00000189283FHIT10074.359ENSSMAG00000003151fhit9973.154Scophthalmus_maximus
ENSG00000189283FHIT9979.221ENSSDUG00000007190fhit9776.351Seriola_dumerili
ENSG00000189283FHIT9980.519ENSSLDG00000020653fhit9777.027Seriola_lalandi_dorsalis
ENSG00000189283FHIT10093.590ENSSARG00000008738FHIT10091.275Sorex_araneus
ENSG00000189283FHIT10088.462ENSSPUG00000000360-10083.221Sphenodon_punctatus
ENSG00000189283FHIT9980.519ENSSPAG00000012817fhit9780.556Stegastes_partitus
ENSG00000189283FHIT10079.487ENSTRUG00000024097FHIT9677.241Takifugu_rubripes
ENSG00000189283FHIT10089.744ENSTTRG00000013200FHIT10088.591Tursiops_truncatus
ENSG00000189283FHIT10096.154ENSVPAG00000010664FHIT10093.289Vicugna_pacos
ENSG00000189283FHIT10075.641ENSXETG00000022969fhit10075.000Xenopus_tropicalis
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000166nucleotide binding-IEAFunction
GO:0001650fibrillar center-IDAComponent
GO:0003824catalytic activity8598045.TASFunction
GO:0005515protein binding18077326.IPIFunction
GO:0005737cytoplasm15007172.IDAComponent
GO:0005739mitochondrion-IEAComponent
GO:0005829cytosol15313915.IDAComponent
GO:0005886plasma membrane-IDAComponent
GO:0006163purine nucleotide metabolic process9323207.IDAProcess
GO:0009117nucleotide metabolic process8794732.TASProcess
GO:0016787hydrolase activity8794732.IDAFunction
GO:0031625ubiquitin protein ligase binding15313915.IPIFunction
GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process15313915.IMPProcess
GO:0042802identical protein binding9261067.9576908.16189514.18077326.25416956.27107012.IPIFunction
GO:0047710bis(5'-adenosyl)-triphosphatase activity8794732.9323207.IDAFunction
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator15313915.IMPProcess
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