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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27220399HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells.Mol Med Rep2016 JulWang Zdoi: 10.3892/mmr.2016.5340
23723299HMGB1 in cancer: good, bad, or both?Clin Cancer Res2013 Aug 1Kang Rdoi: 10.1158/1078-0432.CCR-13-0495
25986235Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer.J Exp Clin Cancer Res2015 May 20Zhang Zdoi: 10.1186/s13046-015-0166-1.
23467607Overexpression of high mobility group protein B1 correlates with the proliferation and metastasis of lung adenocarcinoma cells.Mol Med Rep2013 MaySun KKdoi: 10.3892/mmr.2013.1362
26952810Macrophage migration inhibitory factor promotes breast cancer metastasis via activation of HMGB1/TLR4/NF kappa B axis.Cancer Lett2016 Jun 1Lv Wdoi: 10.1016/j.canlet.2016.02.005
24146279HMGB1 combining with tumor-associated macrophages enhanced lymphangiogenesis in human epithelial ovarian cancer.Tumour Biol2014 MarZhang Wdoi: 10.1007/s13277-013-1288-8
26922571Cytoplasmic expression of high mobility group B1 (HMGB1) is associated with tumor-infiltrating lymphocytes (TILs) in breast cancer.Pathol Int2016 AprLee HJdoi: 10.1111/pin.12393
19445369[Immunological aspects of anticancer chemotherapy].Bull Acad Natl Med2008 OctZitvogel L-
24681824The role of high mobility group box 1 (HMGB1) in colorectal cancer.Med Sci Monit2014 Mar 31S??ren Ddoi: 10.12659/MSM.890531.
23318458The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics.Oncogene2014 Jan 30Kang Rdoi: 10.1038/onc.2012.631
26617792MiR-142-3p functions as a potential tumor suppressor directly targeting HMGB1 in non-small-cell lung carcinoma.Int J Clin Exp Pathol2015 Sep 1Xiao P-
22747650High expression of high mobility group box 1 (hmgb1) predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy.J Transl Med2012 Jul 2Liu Fdoi: 10.1186/1479-5876-10-135.
25639284HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients.Oral Dis2015 MaySupic Gdoi: 10.1111/odi.12318
24213571High mobility group box 1 promotes tumor cell migration through epigenetic silencing of semaphorin 3A.Oncogene2014 Oct 30Nehil Mdoi: 10.1038/onc.2013.459
22105604Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1).Mol Med2012 Mar 30Yang Hdoi: 10.2119/molmed.2011.00389.
21181308HMGB1 promotes lymphangiogenesis of human lymphatic endothelial cells in vitro.Med Oncol2012 MarQiu Ydoi: 10.1007/s12032-010-9778-7
15201494Effects of HMGB-1 overexpression on cell-cycle progression in MCF-7 cells.J Korean Med Sci2004 JunYoon S-
20622903HMGB1 release and redox regulates autophagy and apoptosis in cancer cells.Oncogene2010 Sep 23Tang Ddoi: 10.1038/onc.2010.261
21120500Elevated plasma level of HMGB1 is associated with disease activity and combined alterations with IFN-α and TNF-α in systemic lupus erythematosus.Rheumatol Int2012 FebMa CYdoi: 10.1007/s00296-010-1636-6
26106610HMGB1-Induced Cross Talk between PTEN and miRs 221/222 in Thyroid Cancer.Biomed Res Int2015Mardente Sdoi: 10.1155/2015/512027
21642542Knockdown of HMGB1 in tumor cells attenuates their ability to induce regulatory T cells and uncovers naturally acquired CD8 T cell-dependent antitumor immunity.J Immunol2011 Jul 1Liu Zdoi: 10.4049/jimmunol.1003378
24481712Knockdown of HMGB1 inhibits growth and invasion of gastric cancer cells through the NF-??B pathway in vitro and in vivo.Int J Oncol2014 AprZhang Jdoi: 10.3892/ijo.2014.2285
23836405Invasion potential of H22 hepatocarcinoma cells is increased by HMGB1-induced tumor NF-??B signaling via initiation of HSP70.Oncol Rep2013 SepGong Wdoi: 10.3892/or.2013.2595
23042506Expression and clinical significance of HMGB1 in human liver cancer: Knockdown inhibits tumor growth and metastasis in vitro and in vivo.Oncol Rep2013 JanDong YDdoi: 10.3892/or.2012.2070
22842346Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.Nat Immunol2012 SepChiba Sdoi: 10.1038/ni.2376
24078503Cytosolic HMGB1 expression in human renal clear cell cancer indicates higher pathological T classifications and tumor grades.Urol J2013 Sep 26Takeuchi T-
22265157HMGB1 is overexpressed in tumor cells and promotes activity of regulatory T cells in patients with head and neck cancer.Oral Oncol2012 MayWild CAdoi: 10.1016/j.oraloncology.2011.12.009
27769864HMGB1 induces human non-small cell lung cancer cell motility by activating integrin αvβ3/FAK through TLR4/NF-??B signaling pathway.Biochem Biophys Res Commun2016 Nov 25Zhu Jdoi: 10.1016/j.bbrc.2016.10.052
28216372Hepatitis B virus X protein stimulates high mobility group box 1 secretion and enhances hepatocellular carcinoma metastasis.Cancer Lett2017 May 28Chen Sdoi: 10.1016/j.canlet.2017.02.011
28574630High-mobility group box-1 contributes tumor angiogenesis under interleukin-8 mediation during gastric cancer progression.Cancer Sci2017 AugChung HWdoi: 10.1111/cas.13288
27262996Pivotal role of high-mobility group box 1 (HMGB1) signaling pathways in glioma development and progression.J Mol Med (Berl)2016 AugAngelopoulou Edoi: 10.1007/s00109-016-1435-y
29848691Clinical Implication of the Relationship Between High Mobility Group Box-1 and Tumor Differentiation in Hepatocellular Carcinoma.Anticancer Res2018 JunAndo Kdoi: 10.21873/anticanres.12609.
29679570HMGB1-containing nucleosome mediates chemotherapy-induced metastasis of human lung cancer.Biochem Biophys Res Commun2018 Jun 7Wang Kdoi: 10.1016/j.bbrc.2018.04.150
29562957miR-449a Suppresses Tumor Growth, Migration, and Invasion in Non-Small Cell Lung Cancer by Targeting a HMGB1-Mediated NF-??B Signaling Pathway.Oncol Res2019 Feb 5Wu Ddoi: 10.3727/096504018X15213089759999
30375073HMGB1 knock-down promoting tumor cells viability and arrest pro-apoptotic proteins via Stat3/NF??B in HepG2 cells.Biofactors2018 NovAlduais Sdoi: 10.1002/biof.1456
20846416Co-expression of nuclear and cytoplasmic HMGB1 is inversely associated with infiltration of CD45RO+ T cells and prognosis in patients with stage IIIB colon cancer.BMC Cancer2010 Sep 16Peng RQdoi: 10.1186/1471-2407-10-496.
19571604Suppression of dendritic cells by HMGB1 is associated with lymph node metastasis of human colon cancer.Pathobiology2009Kusume Adoi: 10.1159/000218331
26720492mir-129-5p Attenuates Irradiation-Induced Autophagy and Decreases Radioresistance of Breast Cancer Cells by Targeting HMGB1.Med Sci Monit2015 Dec 31Luo J-
19148477Short hairpin RNA (shRNA) constructs targeting high mobility group box-1 (HMGB1) expression leads to inhibition of prostate cancer cell survival and apoptosis.Int J Oncol2009 FebGnanasekar M-
25277185High mobility group Box-1 inhibits cancer cell motility and metastasis by suppressing activation of transcription factor CREB and nWASP expression.Oncotarget2014 Sep 15Zuo Z-
27049097Changes of HMGB1 expression on angiogenesis of ovarian cancer and its mechanism.J Biol Regul Homeost Agents2016 Jan-MarZhou LY-
27829233MiR-142 inhibits the development of cervical cancer by targeting HMGB1.Oncotarget2017 Jan 17Jiang Ddoi: 10.18632/oncotarget.13136.
29355524Long non-coding RNA UCA1 promotes lung cancer cell proliferation and migration via microRNA-193a/HMGB1 axis.Biochem Biophys Res Commun2018 Feb 5Wu Hdoi: 10.1016/j.bbrc.2018.01.097
27391431HMGB1 overexpression as a prognostic factor for survival in cancer: a meta-analysis and systematic review.Oncotarget2016 Aug 2Wu Tdoi: 10.18632/oncotarget.10413.
29104475Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects.Int J Med Sci2017 Sep 19Hu Wdoi: 10.7150/ijms.20933
29845254High mobility group box 1 promotes the epithelial-to-mesenchymal transition in prostate cancer PC3 cells via the RAGE/NF-??B signaling pathway.Int J Oncol2018 AugZhang Jdoi: 10.3892/ijo.2018.4420
30257412MiR-1284 enhances sensitivity of cervical cancer cells to cisplatin via downregulating HMGB1.Biomed Pharmacother2018 NovChen Jdoi: 10.1016/j.biopha.2018.08.059
22750245High mobility group box-1 is phosphorylated by protein kinase C zeta and secreted in colon cancer cells.Biochem Biophys Res Commun2012 Jul 27Lee Hdoi: 10.1016/j.bbrc.2012.06.116
26305032Clinical impact of high mobility group box 1 protein in epithelial ovarian cancer.Arch Gynecol Obstet2016 MarPaek Jdoi: 10.1007/s00404-015-3864-1
24965109High Mobility Group Box1 (HMGB1) released from cancer cells induces the expression of pro-inflammatory cytokines in peritoneal fibroblasts.Pathol Int2014 JunAbe Adoi: 10.1111/pin.12167.
20430742Serum levels of HMGB1, survivin, and VEGF in patients with advanced non-small cell lung cancer during chemotherapy.Folia Histochem Cytobiol2009Naumnik Wdoi: 10.2478/v10042-009-0025-z.
22237993Increased expression of HMGB1 is associated with poor prognosis in human bladder cancer.J Surg Oncol2012 Jul 1Yang GLdoi: 10.1002/jso.23040
19476625Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer.J Transl Med2009 May 28Chung HWdoi: 10.1186/1479-5876-7-38.
19639200The expression of high-mobility group protein box 1 correlates with the progression of non-small cell lung cancer.Oncol Rep2009 SepShen X-
24705787Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology.PLoS One2014 Apr 4Moser Bdoi: 10.1371/journal.pone.0094118
25872129The chemokine receptors CXCR4/CXCR7 and their primary heterodimeric ligands CXCL12 and CXCL12/high mobility group box 1 in pancreatic cancer growth and development: finding flow.Pancreas2015 MayShakir Mdoi: 10.1097/MPA.0000000000000298.
23866030Double-positive expression of high-mobility group box 1 and vascular endothelial growth factor C indicates a poorer prognosis in gastric cancer patients.World J Surg Oncol2013 Jul 18He Wdoi: 10.1186/1477-7819-11-161.
26896489The repair capacity of lung cancer cell lines A549 and H1299 depends on HMGB1 expression level and the p53 status.J Biochem2016 JulYusein-Myashkova Sdoi: 10.1093/jb/mvw012
21953494Effect of HMGB1 silencing on cell proliferation, invasion and apoptosis of MGC-803 gastric cancer cells.Cell Biochem Funct2012 JanSong Bdoi: 10.1002/cbf.1811
20812762Analysis of nuclear high mobility group box 1 (HMGB1)-binding proteins in colon cancer cells: clustering with proteins involved in secretion and extranuclear function.J Proteome Res2010 Sep 3Lee Hdoi: 10.1021/pr100386r.
22108005Autophagy-mediated HMGB1 release antagonizes apoptosis of gastric cancer cells induced by vincristine via transcriptional regulation of Mcl-1.Autophagy2012 JanZhan Zdoi: 10.4161/auto.8.1.18319
20193282[Effects of high mobility group box-1 silencing upon the invasion and proliferation in human lung cancer cell L9981 by RNA inhibition].Zhonghua Yi Xue Za Zhi2009 Dec 1Zhang P-
26001393High-mobility group box 1 protein activating nuclear factor-??B to upregulate vascular endothelial growth factor C is involved in lymphangiogenesis and lymphatic node metastasis in colon cancer.J Int Med Res2015 AugLi Ydoi: 10.1177/0300060515581671
24710933miR-200c inhibits metastasis of breast cancer cells by targeting HMGB1.J Huazhong Univ Sci Technolog Med Sci2014 AprChang BPdoi: 10.1007/s11596-014-1259-3
25572734Clinical significance of hmgb1 expression in human gastric cancer.Int J Immunopathol Pharmacol2014 Oct-DecZhang J-
25776482Expression of MicroRNA-325-3p and its potential functions by targeting HMGB1 in non-small cell lung cancer.Biomed Pharmacother2015 MarYao Sdoi: 10.1016/j.biopha.2015.01.013
26719575The Role of HMGB1 in Radioresistance of Bladder Cancer.Mol Cancer Ther2016 MarShrivastava Sdoi: 10.1158/1535-7163.MCT-15-0581
20123075High-mobility group box 1 and cancer.Biochim Biophys Acta2010 Jan-FebTang Ddoi: 10.1016/j.bbagrm.2009.11.014.
25622595Immunohistochemical detection of high-mobility group box 1 correlates with resistance of preoperative chemoradiotherapy for lower rectal cancer: a retrospective study.World J Surg Oncol2015 Jan 27Hongo Kdoi: 10.1186/1477-7819-13-7.
17504981Masquerader: high mobility group box-1 and cancer.Clin Cancer Res2007 May 15Ellerman JE-
22983919Circulating immunogenic cell death biomarkers HMGB1 and RAGE in breast cancer patients during neoadjuvant chemotherapy.Tumour Biol2013 FebStoetzer OJdoi: 10.1007/s13277-012-0513-1
26261503Expression of HMGB1/RAGE protein in renal carcinoma and its clinical significance.Int J Clin Exp Pathol2015 Jun 1Qie GQ-
27383136HMGB1 Enhances Drug Resistance and Promotes In Vivo Tumor Growth of Lung Cancer Cells.DNA Cell Biol2016 OctZheng H-
20185963HMGB1 attenuates anti-metastatic defense of the lymph nodes in colorectal cancer.Pathobiology2010Moriwaka Ydoi: 10.1159/000272950
15666359Receptor for advanced glycation end products (RAGE) and its ligand, amphoterin are overexpressed and associated with prostate cancer development.Prostate2005 Jun 15Ishiguro H-
26948869The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration.Nat Commun2016 Mar 7Gdynia Gdoi: 10.1038/ncomms10764.
16951227DNA repair pathway profiling and microsatellite instability in colorectal cancer.Clin Cancer Res2006 Sep 1Yu J-
23175347[HMGB1--its role in tumor progression and anticancer therapy].Postepy Hig Med Dosw (Online)2012 Nov 22Smolarczyk Rdoi: 10.5604/17322693.1021108.
25652880Autophagy-mediated HMGB1 release promotes gastric cancer cell survival via RAGE activation of extracellular signal-regulated kinases 1/2.Oncol Rep2015 AprZhang QYdoi: 10.3892/or.2015.3782
23023232HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells.Oncol Rep2012 DecMardente Sdoi: 10.3892/or.2012.2058
14534709Amphoterin induction in prostatic stromal cells by androgen deprivation is associated with metastatic prostate cancer.Oncol Rep2003 Nov-DecKuniyasu H-
26884867HMGB1 silence could promote MCF-7 cell apoptosis and inhibit invasion and metastasis.Int J Clin Exp Pathol2015 Dec 1Ni P-
25684181Nuclear DAMP complex-mediated RAGE-dependent macrophage cell death.Biochem Biophys Res Commun2015 Mar 13Chen Rdoi: 10.1016/j.bbrc.2015.01.159
27116470Prognostic Significance of Tag SNP rs1045411 in HMGB1 of the Aggressive Gastric Cancer in a Chinese Population.PLoS One2016 Apr 26Bao Gdoi: 10.1371/journal.pone.0154378
25501936Downregulation of high mobility group box 1 modulates telomere homeostasis and increases the radiosensitivity of human breast cancer cells.Int J Oncol2015 MarKe Sdoi: 10.3892/ijo.2014.2793
26916160Dichotomous Life of DNA Binding High Mobility Group Box1 Protein in Human Health and Disease.Curr Protein Pept Sci2016Lohani N-
24998555Expression of high mobility group box - B1 (HMGB-1) and matrix metalloproteinase-9 (MMP-9) in non-small cell lung cancer (NSCLC).Asian Pac J Cancer Prev2014Wang JL-
28000879High-mobility group box 1 is overexpressed in cervical carcinoma and promotes cell invasion and migration invitro.Oncol Rep2017 FebPang Xdoi: 10.3892/or.2016.5317
26979829Mesenchymal-epithelial signalling in tumour microenvironment: role of high-mobility group Box 1.Cell Tissue Res2016 AugSharma Sdoi: 10.1007/s00441-016-2389-7
28347236High mobility group box 1/toll-like receptor 4/myeloid differentiation factor 88 signaling promotes progression of gastric cancer.Tumour Biol2017 MarYue Ydoi: 10.1177/1010428317694312.
27959427Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells.Mol Med Rep2017 JanXia Jdoi: 10.3892/mmr.2016.6003
28376901Down-regulation of LncRNA TUG1 enhances radiosensitivity in bladder cancer via suppressing HMGB1 expression.Radiat Oncol2017 Apr 4Jiang Hdoi: 10.1186/s13014-017-0802-3.
28427045MiR-142-3p Overexpression Increases Chemo-Sensitivity of NSCLC by Inhibiting HMGB1-Mediated Autophagy.Cell Physiol Biochem2017Chen Ydoi: 10.1159/000467896
27241711Genetic predisposition of six well-defined polymorphisms in HMGB1/RAGE pathway to breast cancer in a large Han Chinese population.J Cell Mol Med2016 OctYue Ldoi: 10.1111/jcmm.12888
27987020Bio-HMGB1 from breast cancer contributes to M-MDSC differentiation from bone marrow progenitor cells and facilitates conversion of monocytes into MDSC-like cells.Cancer Immunol Immunother2017 MarSu Zdoi: 10.1007/s00262-016-1942-2
27457217Prognostic value of HMGB1 in early breast cancer patients under neoadjuvant chemotherapy.Cancer Med2016 SepExner Rdoi: 10.1002/cam4.827
28802057High-mobility group box 1 released by autophagic cancer-associated fibroblasts maintains the stemness of luminal breast cancer cells.J Pathol2017 NovZhao XLdoi: 10.1002/path.4958
26840258The effect of HMGB1 on the clinicopathological and prognostic features of non-small cell lung cancer.Oncotarget2016 Apr 12Feng Adoi: 10.18632/oncotarget.7050.
27834305Postoperative changes in high mobility group box 1 levels after colorectal cancer surgery.J Int Med Res2017 DecSatoh Mdoi: 10.1177/0300060516665455
29725248HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer.Int J Med Sci2018 Mar 12Huang BFdoi: 10.7150/ijms.23462
29730397High-mobility group box 1 protein (HMGB1) gene polymorphisms and cancer susceptibility: A comprehensive meta-analysis.Clin Chim Acta2018 AugKumari Tdoi: 10.1016/j.cca.2018.04.042
29850505High Mobility Group Box Protein 1 Serves as a Potential Prognostic Marker of Lung Cancer and Promotes Its Invasion and Metastasis by Matrix Metalloproteinase-2 in a Nuclear Factor-??B-Dependent Manner.Biomed Res Int2018 Apr 19Wu Xdoi: 10.1155/2018/3453706
29753015LncRNA ZEB2-AS1 promotes pancreatic cancer cell growth and invasion through regulating the miR-204/HMGB1 axis.Int J Biol Macromol2018 SepGao Hdoi: 10.1016/j.ijbiomac.2018.05.044
28885675Up-regulated HMGB1 in the pleural effusion of non-small cell lung cancer (NSCLC) patients reduces the chemosensitivity of NSCLC cells.Tumori2018 OctMa Ydoi: 10.5301/tj.5000656
30066846Translationally controlled tumor protein affects colorectal cancer metastasis through the high mobility group box 1-dependent pathway.Int J Oncol2018 OctHuang Mdoi: 10.3892/ijo.2018.4502
29947767High linear energy transfer carbon-ion irradiation increases the release of the immune mediator high mobility group box 1 from human cancer cells.J Radiat Res2018 Sep 1Onishi Mdoi: 10.1093/jrr/rry049.
30653121Increased HMGB1 expression correlates with higher expression of c-IAP2 and pERK in colorectal cancer.Medicine (Baltimore)2019 JanZhang Wdoi: 10.1097/MD.0000000000014069.
30373858NAC1/HMGB1 Signaling Pathway Is Associated with Epithelial-mesenchymal Transition, Invasion, and Metastasis of Lung Cancer Cell Line.Ann Clin Lab Sci2018 SepLiu Y-
29270668Cytosolic high-mobility group box protein 1 (HMGB1) and/or PD-1+TILs in the tumor microenvironment may be contributing prognostic biomarkers for patients with locally advanced rectal cancer who have undergone neoadjuvant chemoradiotherapy.Cancer Immunol Immunother2018 AprHuang CYdoi: 10.1007/s00262-017-2109-5
30569171Radiosensitization of esophageal carcinoma cells by knockdown of HMGB1 expression.Oncol Rep2019 MarZhang Xdoi: 10.3892/or.2018.6923

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1330462423Intronnovel0.17
BLCAchr13304612513'UTRnovel0.62
BLCAchr1330461380Nonsense_MutationnovelE209*0.52
BLCAchr1330462677Missense_MutationnovelP111L0.1
BLCAchr1330463337Missense_MutationNAE56Q0.46
BRCAchr13304611993'UTRnovel0.22
BRCAchr13304611593'UTRnovel0.19
BRCAchr13304608543'UTRnovel0.31
BRCAchr1330463561Missense_MutationNAE40D0.24
CESCchr13304611993'UTRnovel0.2
CESCchr1330463266SilentNAI79I0.15
CESCchr13304610933'UTRnovel0.32
CESCchr13304600423'UTRrs5669332340.29
CESCchr13304612733'UTRnovel0.39
CESCchr1330463577Missense_MutationNAS35L0.39
CESCchr13304603993'UTRnovel0.57
CESCchr13304611323'UTRNA0.19
COADchr1330462566Missense_MutationNAA148G0.41
COADchr1330461381Missense_MutationNAE208D0.1
COADchr1330461686IntronNA0.35
COADchr1330462631SilentNAA126A0.33
COADchr1330462562Silentrs753022161A149A0.46
COADchr13304612733'UTRnovel0.26
COADchr13304612193'UTRnovel0.37
COADchr13304612193'UTRnovel0.36
COADchr1330461617Intronnovel0.14
COADchr1330461617Intronnovel0.27
COADchr1330463550Missense_MutationNAK44T0.44
DLBCchr1330463734Intronnovel0.57
ESCAchr13304610453'UTRnovel0.2
ESCAchr1330461378Missense_Mutationrs377691338E209D0.17
ESCAchr1330461629Intronnovel0.33
GBMchr13304611553'UTRnovel0.29
KIRPchr13304613113'UTRnovel0.33
LAMLchr1330462585Nonsense_MutationnovelQ142*0.06
LIHCchr1330461385Missense_MutationnovelD207V0.51
LIHCchr1330462689Missense_MutationnovelS107C0.4
LUADchr1330462451Intronnovel0.31
LUADchr1330463635Missense_MutationnovelY16N0.07
LUADchr1330463556Frame_Shift_DelnovelN37Ifs*340.04
LUSCchr1330461625Intronnovel0.31
LUSCchr1330462697SilentNAL104L0.42
OVchr1330463206Splice_SiteNAX99_splice0.31
OVchr1330463629Frame_Shift_DelnovelG11Ffs*580.22
PCPGchr1330463712Intronnovel0.5
PRADchr1330461649Intronnovel0.29
PRADchr13304612193'UTRnovel0.55
PRADchr1330461569Intronnovel0.42
READchr1330461575Intronnovel0.04
READchr1330462631SilentNAA126A0.41
READchr1330463730Intronnovel0.39
READchr1330462456Intronnovel0.12
SARCchr1330461414Missense_MutationNAE197D0.31
SARCchr13304610123'UTRnovel0.15
SKCMchr13304612873'UTRnovel0.36
SKCMchr1330462543Missense_MutationNAE156K0.06
STADchr1330462656Missense_MutationnovelP118L0.18
STADchr1330462563Missense_Mutationrs758734227A149V0.5
STADchr1330463696Splice_Regionrs7748952180.49
THCAchr1330463553Frame_Shift_DelnovelK43Rfs*330.1
UCECchr13304605743'UTRnovel0.3
UCECchr1330461517Missense_MutationNAR163Q0.35
UCECchr1330461622Intronnovel0.16
UCECchr1330462409Intronnovel0.38
UCECchr13304612183'UTRnovel0.43
UCECchr13304612193'UTRnovel0.31
UCECchr13304612493'UTRnovel0.26
UCECchr13304611593'UTRnovel0.17
UCECchr13304658645'Flanknovel0.47
UCECchr1330462676SilentNAP111P0.42
UCECchr13304611593'UTRnovel0.18
UCECchr1330463762Intronnovel0.14
UCECchr1330463698Splice_Regionnovel0.08
UCECchr13304612883'UTRnovel0.11
UCECchr1330463624Frame_Shift_DelnovelF19Lfs*570.34
UCECchr13304600433'UTRnovel0.37
UCECchr1330463250Missense_MutationNAT85A0.12
UCECchr13304608643'UTRnovel0.26
UCECchr13304600513'UTRnovel0.41
UCECchr13304605223'UTRnovel0.12
UCECchr13304608643'UTRnovel0.45
UCECchr1330461518Nonsense_MutationnovelR163*0.27
UCECchr1330462632Missense_MutationnovelA126V0.3
UCECchr13304600113'UTRnovel0.45
UCECchr13304606643'UTRnovel0.35
UCECchr1330463656Missense_MutationnovelP9S0.42
UCECchr13304658075'Flanknovel0.42
UCECchr13304658935'Flanknovel0.43
UCECchr1330463335Missense_MutationnovelE56D0.33
UCECchr1330461569Intronnovel0.51
UCECchr13304609233'UTRnovel0.59
UCECchr13304601483'UTRnovel0.4
UCECchr13304609003'UTRnovel0.33
UCECchr1330462508Intronnovel0.44
UCECchr1330461686IntronNA0.31
UCECchr13304611373'UTRnovel0.18
UCECchr13304607213'UTRnovel0.27
UCECchr1330462562Silentrs753022161A149A0.29
UCECchr13304602173'UTRnovel0.54
UCECchr13304608853'UTRnovel0.5
UCECchr13304658835'Flanknovel0.09
UCECchr1330462400Intronnovel0.24
UCECchr13304605473'UTRnovel0.19
UCECchr1330462385Intronnovel0.24
UCECchr1330463658Missense_MutationnovelK8R0.13
UCECchr13304598883'UTRnovel0.23
UCECchr13304611323'UTRNA0.07
UCECchr1330463326SilentNAK59K0.16
UCECchr13304601263'UTRnovel0.26
UCECchr1330463648SilentnovelG11G0.35
UCECchr1330461650Intronrs7566388880.32
UCECchr1330462616SilentnovelE131E0.28
UCECchr13304604203'UTRnovel0.18
UCECchr13304612403'UTRnovel0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRCDEL0.12120.031318
MESODEL0.42530.0010209
STADAMP0.31070.01734
THCADEL0.03010.011063

Survival Analysis
CancerP-value Q-value
THYM0.008

Kaplan-Meier Survival Analysis

STAD0.02

Kaplan-Meier Survival Analysis

SARC0.031

Kaplan-Meier Survival Analysis

ACC0.0014

Kaplan-Meier Survival Analysis

UCS0.035

Kaplan-Meier Survival Analysis

SKCM0.013

Kaplan-Meier Survival Analysis

PRAD0.02

Kaplan-Meier Survival Analysis

ESCA0.0076

Kaplan-Meier Survival Analysis

COAD0.03

Kaplan-Meier Survival Analysis

PAAD0.033

Kaplan-Meier Survival Analysis

BLCA0.04

Kaplan-Meier Survival Analysis

KICH0.031

Kaplan-Meier Survival Analysis

LIHC0.031

Kaplan-Meier Survival Analysis

DLBC0.019

Kaplan-Meier Survival Analysis

LGG0.023

Kaplan-Meier Survival Analysis

THCA0.0091

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000189403 (Gene tree)
Gene ID
3146
Gene Symbol
HMGB1
Alias
HMG3|SBP-1|DKFZp686A04236|HMG1
Full Name
high mobility group box 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
160,894 bases
Position
chr13:30,456,704-30,617,597
Accession
4983
RBP type
non-canonical RBP
Summary
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
17649620Differential expression of wheat genes during cold acclimation.Tsitol Genet2007 May-JunChristov NK-
31293389Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model.Front Cell Neurosci2019 Jun 25Wowro SJdoi: 10.3389/fncel.2019.00273
26656705HMGB1 Promotes Hepatitis C Virus Replication by Interaction with Stem-Loop 4 in the Viral 5' Untranslated Region.J Virol2015 Dec 9Yu Rdoi: 10.1128/JVI.02795-15.
30038033hnRNPs Interacting with mRNA Localization Motifs Define Axonal RNA Regulons.Mol Cell Proteomics2018 NovLee SJdoi: 10.1074/mcp.RA118.000603
24005720HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA.Nat Commun2013Dormoy-Raclet Vdoi: 10.1038/ncomms3388.
29484406Pre-B cell leukemia transcription factor 3 induces inflammatory responses in human umbilical vein endothelial cells and murine sepsis via acting a competing endogenous RNA for high mobility group box 1 protein.Mol Med Rep2018 AprZhang Ydoi: 10.3892/mmr.2018.8609
29616096A comprehensive analysis of the predicted targets of miR-642b-3p associated with the long non-coding RNA HOXA11-AS in NSCLC cells.Oncol Lett2018 MayZhang Ydoi: 10.3892/ol.2018.8105
7935371The RNA polymerase I transactivator upstream binding factor requires its dimerization domain and high-mobility-group (HMG) box 1 to bend, wrap, and positively supercoil enhancer DNA.Mol Cell Biol1994 OctPutnam CD-
23407880IFN-γ induces lipogenesis in mouse mesangial cells via the JAK2/STAT1 pathway.Am J Physiol Cell Physiol2013 Apr 15Hao Jdoi: 10.1152/ajpcell.00352.2012
18845125Interactions of recombinant HMGB proteins with branched RNA substrates.Biochem Biophys Res Commun2008 Dec 5Bell AJ Jrdoi: 10.1016/j.bbrc.2008.09.131
20703492HMGB1: the missing link between diabetes mellitus and heart failure.Basic Res Cardiol2010 NovVolz HCdoi: 10.1007/s00395-010-0114-3
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000341423HMGB1-2035485-ENSP00000345347215 (aa)-P09429
ENST00000405805HMGB1-2064199XM_024449340ENSP00000384678215 (aa)XP_024305108P09429
ENST00000339872HMGB1-2022319XM_024449341ENSP00000343040215 (aa)XP_024305109P09429
ENST00000326004HMGB1-201821XM_024449343ENSP00000369904158 (aa)XP_024305111Q5T7C4
ENST00000399494HMGB1-2051282XM_024449342ENSP00000382417215 (aa)XP_024305110P09429
ENST00000468384HMGB1-207503--- (aa)--
ENST00000490788HMGB1-208425--- (aa)--
ENST00000399489HMGB1-2041727-ENSP00000382412158 (aa)-Q5T7C4
Gene Model
Click here to download ENSG00000189403's gene model file
Pathways
Pathway IDPathway NameSource
hsa03410Base excision repairKEGG
hsa04140Autophagy - animalKEGG
hsa04217NecroptosisKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000189403Triglycerides9.785e-005-
ENSG00000189403Triglycerides9.785e-005-
ENSG00000189403Triglycerides9.785e-005-
ENSG00000189403Cholesterol, HDL8.6720000E-005-
ENSG00000189403Lipids3.1590000E-005-
ENSG00000189403Hippocampus7E-621116278
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000189403rs73302091330488053CMean corpuscular hemoglobin27863252[0.016-0.03] unit increase0.02281384EFO_0004527
ENSG00000189403rs95087591330497658AMean corpuscular volume27863252[0.072-0.138] unit increase0.1049438EFO_0004526
ENSG00000189403rs95795861330499729CMean corpuscular volume27863252[0.017-0.032] unit increase0.02451618EFO_0004526
ENSG00000189403rs116182021330539242?Hippocampal volume21116278[NR] unit decrease3.00E-04EFO_0005035
ENSG00000189403rs343445161330586162ACarotid plaque burden28282560[0.082-0.212] unit increase0.14705782EFO_0006501
ENSG00000189403rs13604851330457747?Balding type 130595370EFO_0007825
ENSG00000189403rs95781781330495833AMale-pattern baldness30573740[0.013-0.025] unit decrease0.019137EFO_0007825
ENSG00000189403rs22498251330463766?Body mass index30595370EFO_0004340
ENSG00000189403rs95795831330496075?Mean corpuscular hemoglobin30595370EFO_0004527
ENSG00000189403rs95795831330496075?Red blood cell count30595370EFO_0004305
ENSG00000189403rs10603481330462700?DNA methylation variation (age effect)30348214GO_0006306
ENSG00000189403rs128618241330505047?Eosinophil counts30595370EFO_0004842
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000189403's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000189403HMGB110099.367ENSMUSG00000066551Hmgb1100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II19158276.IGIProcess
GO:0000122negative regulation of transcription by RNA polymerase II19158276.IMPProcess
GO:0000400four-way junction DNA binding-ISSFunction
GO:0000405bubble DNA binding-ISSFunction
GO:0000790nuclear chromatin21873635.IBAComponent
GO:0000793condensed chromosome12925773.IDAComponent
GO:0001530lipopolysaccharide binding21660935.IDAFunction
GO:0001773myeloid dendritic cell activation-ISSProcess
GO:0001786phosphatidylserine binding18768881.IDAFunction
GO:0002218activation of innate immune response21873635.IBAProcess
GO:0002218activation of innate immune response24971542.IDAProcess
GO:0002224toll-like receptor signaling pathway-TASProcess
GO:0002407dendritic cell chemotaxis-ISSProcess
GO:0002437inflammatory response to antigenic stimulus19841752.IEPProcess
GO:0002643regulation of tolerance induction18631454.IDAProcess
GO:0002840regulation of T cell mediated immune response to tumor cell-ISSProcess
GO:0003684damaged DNA binding17803946.IDAFunction
GO:0003684damaged DNA binding-ISSFunction
GO:0003690double-stranded DNA binding-ISSFunction
GO:0003697single-stranded DNA binding-ISSFunction
GO:0003713transcription coactivator activity19223331.IDAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005125cytokine activity-ISSFunction
GO:0005178integrin binding20826760.IDAFunction
GO:0005515protein binding8006019.9472015.11748232.15014079.19505873.20819940.23063560.23303669.24474694.25416956.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005615extracellular space19841752.IDAComponent
GO:0005615extracellular space-ISSComponent
GO:0005634nucleus8339930.19223331.IDAComponent
GO:0005634nucleus-ISSComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005768endosome-IEAComponent
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IEAComponent
GO:0006265DNA topological change-ISSProcess
GO:0006309apoptotic DNA fragmentation-TASProcess
GO:0006310DNA recombination21873635.IBAProcess
GO:0006310DNA recombination-ISSProcess
GO:0006338chromatin remodeling21873635.IBAProcess
GO:0006342chromatin silencing19158276.IGIProcess
GO:0006357regulation of transcription by RNA polymerase II21873635.IBAProcess
GO:0006357regulation of transcription by RNA polymerase II11748232.IDAProcess
GO:0006914autophagy-IEAProcess
GO:0006954inflammatory response23146691.IDAProcess
GO:0007204positive regulation of cytosolic calcium ion concentration22370717.IDAProcess
GO:0008134transcription factor binding21873635.IBAFunction
GO:0008134transcription factor binding19223331.IPIFunction
GO:0008301DNA binding, bending21873635.IBAFunction
GO:0008301DNA binding, bending19223331.IMPFunction
GO:0008301DNA binding, bending-ISSFunction
GO:0009986cell surface19841752.IDAComponent
GO:0010469regulation of signaling receptor activity21873635.IBAProcess
GO:0010506regulation of autophagy20819940.IMPProcess
GO:0010508positive regulation of autophagy21873635.IBAProcess
GO:0016829lyase activity17803946.IDAFunction
GO:0017053transcriptional repressor complex19158276.IDAComponent
GO:0017055negative regulation of RNA polymerase II transcriptional preinitiation complex assembly8006019.IDAProcess
GO:0019958C-X-C chemokine binding22370717.IDAFunction
GO:0031175neuron projection development-ISSProcess
GO:0032072regulation of restriction endodeoxyribonuclease activity17803946.IDAProcess
GO:0032392DNA geometric change-ISSProcess
GO:0032425positive regulation of mismatch repair15014079.IDAProcess
GO:0032502developmental process21873635.IBAProcess
GO:0032689negative regulation of interferon-gamma production22473704.IDAProcess
GO:0032733positive regulation of interleukin-10 production22473704.IDAProcess
GO:0032735positive regulation of interleukin-12 production15944249.IMPProcess
GO:0032755positive regulation of interleukin-6 production21873635.IBAProcess
GO:0032760positive regulation of tumor necrosis factor production21873635.IBAProcess
GO:0033151V(D)J recombination9166431.IDAProcess
GO:0034165positive regulation of toll-like receptor 9 signaling pathway-ISSProcess
GO:0034774secretory granule lumen-TASComponent
GO:0035711T-helper 1 cell activation22473704.IDAProcess
GO:0035868alphav-beta3 integrin-HMGB1 complex20826760.IDAComponent
GO:0042056chemoattractant activity-ISSFunction
GO:0042104positive regulation of activated T cell proliferation15944249.IMPProcess
GO:0043065positive regulation of apoptotic process19800306.IDAProcess
GO:0043277apoptotic cell clearance18768881.IDAProcess
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process19800306.IDAProcess
GO:0043312neutrophil degranulation-TASProcess
GO:0043371negative regulation of CD4-positive, alpha-beta T cell differentiation22473704.IDAProcess
GO:0043388positive regulation of DNA binding11748232.19223331.IDAProcess
GO:0043410positive regulation of MAPK cascade12765338.IDAProcess
GO:0043536positive regulation of blood vessel endothelial cell migration28276476.IMPProcess
GO:0043537negative regulation of blood vessel endothelial cell migration23148224.IDAProcess
GO:0044212transcription regulatory region DNA binding19158276.IDAFunction
GO:0045063T-helper 1 cell differentiation15944249.IMPProcess
GO:0045087innate immune response-TASProcess
GO:0045089positive regulation of innate immune response21873635.IBAProcess
GO:0045944positive regulation of transcription by RNA polymerase II21873635.IBAProcess
GO:0045944positive regulation of transcription by RNA polymerase II19223331.IDAProcess
GO:0046330positive regulation of JNK cascade12765338.IDAProcess
GO:0050716positive regulation of interleukin-1 secretion21873635.IBAProcess
GO:0050716positive regulation of interleukin-1 secretion12765338.IDAProcess
GO:0050718positive regulation of interleukin-1 beta secretion21873635.IBAProcess
GO:0050786RAGE receptor binding-ISSFunction
GO:0050918positive chemotaxis-IEAProcess
GO:0051103DNA ligation involved in DNA repair-ISSProcess
GO:0051106positive regulation of DNA ligation-ISSProcess
GO:0060326cell chemotaxis21873635.IBAProcess
GO:0070182DNA polymerase binding17803946.IDAFunction
GO:0070374positive regulation of ERK1 and ERK2 cascade21873635.IBAProcess
GO:0070374positive regulation of ERK1 and ERK2 cascade22370717.IDAProcess
GO:0070491repressing transcription factor binding19223331.IPIFunction
GO:0071222cellular response to lipopolysaccharide-ISSProcess
GO:0090026positive regulation of monocyte chemotaxis22370717.IDAProcess
GO:0097100supercoiled DNA binding-ISSFunction
GO:0097350neutrophil clearance18768881.IDAProcess
GO:1901224positive regulation of NIK/NF-kappaB signaling21873635.IBAProcess
GO:1902741positive regulation of interferon-alpha secretion21873635.IBAProcess
GO:1904813ficolin-1-rich granule lumen-TASComponent
GO:1905564positive regulation of vascular endothelial cell proliferation28276476.IMPProcess
GO:1990774tumor necrosis factor secretion12765338.IDAProcess
GO:2000426negative regulation of apoptotic cell clearance20826760.IDAProcess
GO:2000778positive regulation of interleukin-6 secretion12765338.IDAProcess
GO:2001200positive regulation of dendritic cell differentiation15944249.IMPProcess
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