EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20103599Human mutations that confer paclitaxel resistance.Mol Cancer Ther2010 FebYin Sdoi: 10.1158/1535-7163.MCT-09-0674
21327297Targeting S100P inhibits colon cancer growth and metastasis by Lentivirus-mediated RNA interference and proteomic analysis.Mol Med2011Jiang Ldoi: 10.2119/molmed.2011.00008
12826311New insights in beta-tubulin sequence analysis in non-small cell lung cancer.Lung Cancer2003 Julde Castro J-
12209587Mutational analysis of the class I beta-tubulin gene in human breast cancer.Int J Cancer2002 Sep 1Hasegawa S-
23818224Tubulin-interactive stilbene derivatives as anticancer agents.Cell Mol Biol Lett2013 SepMikstacka Rdoi: 10.2478/s11658-013-0094-z
21881916Anti-neoplastic agent thymoquinone induces degradation of α and β tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts.Invest New Drugs2012 OctAlhosin Mdoi: 10.1007/s10637-011-9734-1

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr630722989Missense_MutationNAP80S0.12
BLCAchr630723889Missense_MutationnovelR276H0.09
BLCAchr630722555Missense_MutationnovelD26N0.22
BLCAchr630724022SilentnovelR320R0.23
BRCAchr630722969Frame_Shift_DelnovelD74Afs*540.05
BRCAchr630723417Missense_MutationNAV119M0.48
BRCAchr630723707SilentNAL215L0.5
BRCAchr630724389Missense_MutationNAE443Q0.45
BRCAchr630724193SilentnovelL377L0.28
CESCchr6307244573'UTRNA0.11
CESCchr6307204595'UTRnovel0.14
CESCchr630723892Missense_MutationnovelG277E0.07
CESCchr630723431In_Frame_InsnovelE125_S126insVAE0.05
CESCchr630720508Translation_Start_SitenovelM1?0.15
CESCchr630723518SilentNAI152I0.3
CESCchr630724049SilentNAQ329Q0.33
CESCchr630723914SilentnovelL284L0.31
CESCchr630723642Missense_MutationNAE194Q0.49
CHOLchr630723710SilentnovelK216K0.1
COADchr630724350Missense_Mutationrs772090260A430T0.28
COADchr630723578SilentNAS172S0.17
COADchr630723483Frame_Shift_DelnovelG142Afs*230.35
COADchr630724370Silentrs3873307F436F0.31
COADchr630724077Missense_MutationnovelS339G0.27
COADchr630724013Missense_MutationnovelF317L0.1
COADchr6307204405'UTRnovel0.33
COADchr630723389Silentrs139202417G109G0.22
DLBCchr630724254Missense_MutationnovelY398H0.21
GBMchr630722560SilentNAE27E0.08
GBMchr630722549Missense_MutationnovelI24L0.1
GBMchr630723742Missense_MutationnovelH227L0.12
HNSCchr6307244393'UTRrs7742538960.57
HNSCchr630722558Missense_MutationnovelE27K0.33
HNSCchr6307204865'UTRrs7521259420.18
HNSCchr630723654Missense_MutationnovelE198Q0.05
HNSCchr6307204485'UTRnovel0.45
KIRCchr630723704SilentNAT214T0.3
KIRCchr630724349SilentNAT429T0.29
KIRCchr630720516Missense_MutationNAI4L0.24
KIRCchr630723759Frame_Shift_DelnovelM233Cfs*140.3
KIRCchr630723436Missense_MutationnovelE125G0.17
KIRPchr630723949Missense_MutationnovelA296G0.33
LGGchr630722640Missense_MutationnovelA54V0.61
LGGchr630723440Silentrs147158826S126S0.37
LIHCchr6307244743'UTRnovel0.25
LIHCchr630723364Frame_Shift_DelnovelK103Pfs*260.27
LUADchr6307204195'UTRnovel0.2
LUADchr630723924Missense_MutationNAE288K0.2
LUADchr630724138Missense_MutationNAR359P0.44
LUSCchr6307204475'UTRnovel0.15
LUSCchr630723563Silentrs756485442F167F0.25
LUSCchr630723359SilentnovelN99N0.13
LUSCchr630724148SilentnovelK362K0.42
OVchr6307245533'UTRrs5588088890.23
OVchr630724256SilentnovelY398Y0.18
OVchr6307245803'UTRnovel0.46
OVchr630722596Missense_MutationnovelD39E0.73
OVchr630723482Silentrs773923877G140G0.13
SARCchr630724265SilentnovelE401E0.11
SKCMchr630722539Splice_RegionnovelF20F0.74
SKCMchr630723975Missense_MutationnovelP305S0.25
SKCMchr630723496Missense_MutationnovelS145F0.51
SKCMchr630723788SilentNAF242F0.31
SKCMchr630722989Missense_MutationNAP80S0.3
SKCMchr630724097SilentnovelI345I0.34
STADchr630723884SilentNAT274T0.41
STADchr630724370Silentrs3873307F436F0.11
STADchr6307204405'UTRnovel0.41
STADchr6307204975'UTRnovel0.33
TGCTchr6307244273'UTRnovel0.24
TGCTchr630723775Missense_MutationnovelT238N0.13
THYMchr6307244183'UTRrs5463648910.18
UCECchr630723389Silentrs139202417G109G0.44
UCECchr630723017Missense_MutationnovelN89S0.21
UCECchr630724053Missense_MutationnovelL331I0.19
UCECchr6307204895'UTRnovel0.38
UCECchr630723813Missense_MutationnovelR251C0.08
UCECchr630723596Silentrs755066806T178T0.24
UCECchr630723406Missense_MutationnovelS115Y0.49
UCECchr6307204395'UTRnovel0.32
UCECchr6307204255'UTRnovel0.46
UCECchr630724317Missense_MutationnovelV419I0.37
UCECchr630723560SilentNAT166T0.26
UCECchr630723531Nonsense_MutationnovelE157*0.05
UCECchr6307204405'UTRnovel0.32
UCECchr630723626Silentrs140428951S188S0.35
UCECchr630723944SilentnovelF294F0.35
UCECchr630724108Missense_MutationnovelV349D0.35
UCECchr6307204405'UTRnovel0.54

Copy Number Variations (CNVs)
CancerTypeFreq Q-value

Survival Analysis
CancerP-value Q-value
THYM0.0091

Kaplan-Meier Survival Analysis

KIRC0.0016

Kaplan-Meier Survival Analysis

SARC0.00012

Kaplan-Meier Survival Analysis

ACC0.00018

Kaplan-Meier Survival Analysis

HNSC0.038

Kaplan-Meier Survival Analysis

SKCM0.0017

Kaplan-Meier Survival Analysis

ESCA0.029

Kaplan-Meier Survival Analysis

KIRP0.00021

Kaplan-Meier Survival Analysis

COAD0.013

Kaplan-Meier Survival Analysis

PAAD0.032

Kaplan-Meier Survival Analysis

READ0.019

Kaplan-Meier Survival Analysis

KICH0.013

Kaplan-Meier Survival Analysis

UCEC0.011

Kaplan-Meier Survival Analysis

LIHC0.0014

Kaplan-Meier Survival Analysis

DLBC0.021

Kaplan-Meier Survival Analysis

LGG0.007

Kaplan-Meier Survival Analysis

UVM0.0086

Kaplan-Meier Survival Analysis

OV0.012

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000196230 (Gene tree)
Gene ID
203068
Gene Symbol
TUBB
Alias
OK/SW-cl.56|MGC16435|M40|Tubb5
Full Name
tubulin beta class I
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
5,226 bases
Position
chr6:30,720,201-30,725,426
Accession
20778
RBP type
non-canonical RBP
Summary
This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
24810581Validation of potential reference genes for qPCR in maize across abiotic stresses, hormone treatments, and tissue types.PLoS One2014 May 8Lin Ydoi: 10.1371/journal.pone.0095445
25368985Identification of potential serum proteomic biomarkers for clear cell renal cell carcinoma.PLoS One2014 Nov 4Yang Jdoi: 10.1371/journal.pone.0111364
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000396389TUBB-2082903-ENSP00000379672426 (aa)-Q5JP53
ENST00000327892TUBB-2052670-ENSP00000339001444 (aa)-P07437
ENST00000396384TUBB-2072823-ENSP00000379668372 (aa)-Q5ST81
ENST00000330914TUBB-2062632-ENSP00000365578372 (aa)-Q5ST81
Gene Model
Click here to download ENSG00000196230's gene model file
Pathways
Pathway IDPathway NameSource
hsa04145PhagosomeKEGG
hsa04540Gap junctionKEGG
hsa05130Pathogenic Escherichia coli infectionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000196230Multiple Sclerosis3E-619010793
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196230's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000196230TUBB100100.000ENSMUSG00000001525Tubb5100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000086G2/M transition of mitotic cell cycle-TASProcess
GO:0000226microtubule cytoskeleton organization21873635.IBAProcess
GO:0000278mitotic cell cycle21873635.IBAProcess
GO:0003924GTPase activity-IEAFunction
GO:0005198structural molecule activity12090300.TASFunction
GO:0005200structural constituent of cytoskeleton21873635.IBAFunction
GO:0005515protein binding18457437.20195357.21044950.24275654.24375412.24947832.25609649.IPIFunction
GO:0005525GTP binding21873635.IBAFunction
GO:0005576extracellular region-TASComponent
GO:0005634nucleus21630459.HDAComponent
GO:0005641nuclear envelope lumen19567321.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm23178297.IDAComponent
GO:0005856cytoskeleton16130169.TASComponent
GO:0005874microtubule21873635.IBAComponent
GO:0005874microtubule21525035.IDAComponent
GO:0005874microtubule12090300.TASComponent
GO:0007017microtubule-based process21873635.IBAProcess
GO:0007017microtubule-based process12090300.TASProcess
GO:0009987cellular process19567321.IDAProcess
GO:0010389regulation of G2/M transition of mitotic cell cycle-TASProcess
GO:0019904protein domain specific binding-IEAFunction
GO:0030705cytoskeleton-dependent intracellular transport12090300.TASProcess
GO:0031625ubiquitin protein ligase binding21753002.IPIFunction
GO:0032794GTPase activating protein binding-IEAFunction
GO:0035578azurophil granule lumen-TASComponent
GO:0036464cytoplasmic ribonucleoprotein granule15121898.IDAComponent
GO:0042267natural killer cell mediated cytotoxicity11120798.NASProcess
GO:0042288MHC class I protein binding11120798.IDAFunction
GO:0043312neutrophil degranulation-TASProcess
GO:0044297cell body19567321.IDAComponent
GO:0044877protein-containing complex binding-IEAFunction
GO:0045121membrane raft-IEAComponent
GO:0050807regulation of synapse organization-IEAProcess
GO:0051225spindle assembly-IEAProcess
GO:0051301cell division12090300.TASProcess
GO:0070062extracellular exosome12519789.21362503.23533145.HDAComponent
GO:0097711ciliary basal body-plasma membrane docking-TASProcess
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