EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20103599	Human mutations that confer paclitaxel resistance.	Mol Cancer Ther	2010 Feb	Yin S	doi: 10.1158/1535-7163.MCT-09-0674
21327297	Targeting S100P inhibits colon cancer growth and metastasis by Lentivirus-mediated RNA interference and proteomic analysis.	Mol Med	2011	Jiang L	doi: 10.2119/molmed.2011.00008
12826311	New insights in beta-tubulin sequence analysis in non-small cell lung cancer.	Lung Cancer	2003 Jul	de Castro J	-
12209587	Mutational analysis of the class I beta-tubulin gene in human breast cancer.	Int J Cancer	2002 Sep 1	Hasegawa S	-
23818224	Tubulin-interactive stilbene derivatives as anticancer agents.	Cell Mol Biol Lett	2013 Sep	Mikstacka R	doi: 10.2478/s11658-013-0094-z
21881916	Anti-neoplastic agent thymoquinone induces degradation of α and β tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts.	Invest New Drugs	2012 Oct	Alhosin M	doi: 10.1007/s10637-011-9734-1

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	30722989	Missense_Mutation	NA	P80S	0.12
BLCA	chr6	30723889	Missense_Mutation	novel	R276H	0.09
BLCA	chr6	30722555	Missense_Mutation	novel	D26N	0.22
BLCA	chr6	30724022	Silent	novel	R320R	0.23
BRCA	chr6	30722969	Frame_Shift_Del	novel	*D74Afs54**	0.05
BRCA	chr6	30723417	Missense_Mutation	NA	V119M	0.48
BRCA	chr6	30723707	Silent	NA	L215L	0.5
BRCA	chr6	30724389	Missense_Mutation	NA	E443Q	0.45
BRCA	chr6	30724193	Silent	novel	L377L	0.28
CESC	chr6	30724457	3'UTR	NA		0.11
CESC	chr6	30720459	5'UTR	novel		0.14
CESC	chr6	30723892	Missense_Mutation	novel	G277E	0.07
CESC	chr6	30723431	In_Frame_Ins	novel	E125_S126insVAE	0.05
CESC	chr6	30720508	Translation_Start_Site	novel	M1?	0.15
CESC	chr6	30723518	Silent	NA	I152I	0.3
CESC	chr6	30724049	Silent	NA	Q329Q	0.33
CESC	chr6	30723914	Silent	novel	L284L	0.31
CESC	chr6	30723642	Missense_Mutation	NA	E194Q	0.49
CHOL	chr6	30723710	Silent	novel	K216K	0.1
COAD	chr6	30724350	Missense_Mutation	rs772090260	A430T	0.28
COAD	chr6	30723578	Silent	NA	S172S	0.17
COAD	chr6	30723483	Frame_Shift_Del	novel	*G142Afs23**	0.35
COAD	chr6	30724370	Silent	rs3873307	F436F	0.31
COAD	chr6	30724077	Missense_Mutation	novel	S339G	0.27
COAD	chr6	30724013	Missense_Mutation	novel	F317L	0.1
COAD	chr6	30720440	5'UTR	novel		0.33
COAD	chr6	30723389	Silent	rs139202417	G109G	0.22
DLBC	chr6	30724254	Missense_Mutation	novel	Y398H	0.21
GBM	chr6	30722560	Silent	NA	E27E	0.08
GBM	chr6	30722549	Missense_Mutation	novel	I24L	0.1
GBM	chr6	30723742	Missense_Mutation	novel	H227L	0.12
HNSC	chr6	30724439	3'UTR	rs774253896		0.57
HNSC	chr6	30722558	Missense_Mutation	novel	E27K	0.33
HNSC	chr6	30720486	5'UTR	rs752125942		0.18
HNSC	chr6	30723654	Missense_Mutation	novel	E198Q	0.05
HNSC	chr6	30720448	5'UTR	novel		0.45
KIRC	chr6	30723704	Silent	NA	T214T	0.3
KIRC	chr6	30724349	Silent	NA	T429T	0.29
KIRC	chr6	30720516	Missense_Mutation	NA	I4L	0.24
KIRC	chr6	30723759	Frame_Shift_Del	novel	*M233Cfs14**	0.3
KIRC	chr6	30723436	Missense_Mutation	novel	E125G	0.17
KIRP	chr6	30723949	Missense_Mutation	novel	A296G	0.33
LGG	chr6	30722640	Missense_Mutation	novel	A54V	0.61
LGG	chr6	30723440	Silent	rs147158826	S126S	0.37
LIHC	chr6	30724474	3'UTR	novel		0.25
LIHC	chr6	30723364	Frame_Shift_Del	novel	*K103Pfs26**	0.27
LUAD	chr6	30720419	5'UTR	novel		0.2
LUAD	chr6	30723924	Missense_Mutation	NA	E288K	0.2
LUAD	chr6	30724138	Missense_Mutation	NA	R359P	0.44
LUSC	chr6	30720447	5'UTR	novel		0.15
LUSC	chr6	30723563	Silent	rs756485442	F167F	0.25
LUSC	chr6	30723359	Silent	novel	N99N	0.13
LUSC	chr6	30724148	Silent	novel	K362K	0.42
OV	chr6	30724553	3'UTR	rs558808889		0.23
OV	chr6	30724256	Silent	novel	Y398Y	0.18
OV	chr6	30724580	3'UTR	novel		0.46
OV	chr6	30722596	Missense_Mutation	novel	D39E	0.73
OV	chr6	30723482	Silent	rs773923877	G140G	0.13
SARC	chr6	30724265	Silent	novel	E401E	0.11
SKCM	chr6	30722539	Splice_Region	novel	F20F	0.74
SKCM	chr6	30723975	Missense_Mutation	novel	P305S	0.25
SKCM	chr6	30723496	Missense_Mutation	novel	S145F	0.51
SKCM	chr6	30723788	Silent	NA	F242F	0.31
SKCM	chr6	30722989	Missense_Mutation	NA	P80S	0.3
SKCM	chr6	30724097	Silent	novel	I345I	0.34
STAD	chr6	30723884	Silent	NA	T274T	0.41
STAD	chr6	30724370	Silent	rs3873307	F436F	0.11
STAD	chr6	30720440	5'UTR	novel		0.41
STAD	chr6	30720497	5'UTR	novel		0.33
TGCT	chr6	30724427	3'UTR	novel		0.24
TGCT	chr6	30723775	Missense_Mutation	novel	T238N	0.13
THYM	chr6	30724418	3'UTR	rs546364891		0.18
UCEC	chr6	30723389	Silent	rs139202417	G109G	0.44
UCEC	chr6	30723017	Missense_Mutation	novel	N89S	0.21
UCEC	chr6	30724053	Missense_Mutation	novel	L331I	0.19
UCEC	chr6	30720489	5'UTR	novel		0.38
UCEC	chr6	30723813	Missense_Mutation	novel	R251C	0.08
UCEC	chr6	30723596	Silent	rs755066806	T178T	0.24
UCEC	chr6	30723406	Missense_Mutation	novel	S115Y	0.49
UCEC	chr6	30720439	5'UTR	novel		0.32
UCEC	chr6	30720425	5'UTR	novel		0.46
UCEC	chr6	30724317	Missense_Mutation	novel	V419I	0.37
UCEC	chr6	30723560	Silent	NA	T166T	0.26
UCEC	chr6	30723531	Nonsense_Mutation	novel	E157*	0.05
UCEC	chr6	30720440	5'UTR	novel		0.32
UCEC	chr6	30723626	Silent	rs140428951	S188S	0.35
UCEC	chr6	30723944	Silent	novel	F294F	0.35
UCEC	chr6	30724108	Missense_Mutation	novel	V349D	0.35
UCEC	chr6	30720440	5'UTR	novel		0.54

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0091	Kaplan-Meier Survival Analysis
KIRC	0.0016	Kaplan-Meier Survival Analysis
SARC	0.00012	Kaplan-Meier Survival Analysis
ACC	0.00018	Kaplan-Meier Survival Analysis
HNSC	0.038	Kaplan-Meier Survival Analysis
SKCM	0.0017	Kaplan-Meier Survival Analysis
ESCA	0.029	Kaplan-Meier Survival Analysis
KIRP	0.00021	Kaplan-Meier Survival Analysis
COAD	0.013	Kaplan-Meier Survival Analysis
PAAD	0.032	Kaplan-Meier Survival Analysis
READ	0.019	Kaplan-Meier Survival Analysis
KICH	0.013	Kaplan-Meier Survival Analysis
UCEC	0.011	Kaplan-Meier Survival Analysis
LIHC	0.0014	Kaplan-Meier Survival Analysis
DLBC	0.021	Kaplan-Meier Survival Analysis
LGG	0.007	Kaplan-Meier Survival Analysis
UVM	0.0086	Kaplan-Meier Survival Analysis
OV	0.012	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000196230 (Gene tree)
Gene ID: 203068
Gene Symbol: TUBB
Alias: OK/SW-cl.56|MGC16435|M40|Tubb5
Full Name: tubulin beta class I
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 5,226 bases
Position: chr6:30,720,201-30,725,426
Accession: 20778
RBP type: non-canonical RBP
Summary: This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24810581	Validation of potential reference genes for qPCR in maize across abiotic stresses, hormone treatments, and tissue types.	PLoS One	2014 May 8	Lin Y	doi: 10.1371/journal.pone.0095445
25368985	Identification of potential serum proteomic biomarkers for clear cell renal cell carcinoma.	PLoS One	2014 Nov 4	Yang J	doi: 10.1371/journal.pone.0111364

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000396389	TUBB-208	2903	-	ENSP00000379672	426 (aa)	-	Q5JP53
ENST00000327892	TUBB-205	2670	-	ENSP00000339001	444 (aa)	-	P07437
ENST00000396384	TUBB-207	2823	-	ENSP00000379668	372 (aa)	-	Q5ST81
ENST00000330914	TUBB-206	2632	-	ENSP00000365578	372 (aa)	-	Q5ST81

Gene Model

Click here to download ENSG00000196230's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04145	Phagosome	KEGG
hsa04540	Gap junction	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000196230	Multiple Sclerosis	3E-6	19010793

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196230's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000196230	TUBB	100	100.000	ENSMUSG00000001525	Tubb5	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0000226	microtubule cytoskeleton organization	21873635.	IBA	Process
GO:0000278	mitotic cell cycle	21873635.	IBA	Process
GO:0003924	GTPase activity	-	IEA	Function
GO:0005198	structural molecule activity	12090300.	TAS	Function
GO:0005200	structural constituent of cytoskeleton	21873635.	IBA	Function
GO:0005515	protein binding	18457437.20195357.21044950.24275654.24375412.24947832.25609649.	IPI	Function
GO:0005525	GTP binding	21873635.	IBA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005641	nuclear envelope lumen	19567321.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	23178297.	IDA	Component
GO:0005856	cytoskeleton	16130169.	TAS	Component
GO:0005874	microtubule	21873635.	IBA	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0005874	microtubule	12090300.	TAS	Component
GO:0007017	microtubule-based process	21873635.	IBA	Process
GO:0007017	microtubule-based process	12090300.	TAS	Process
GO:0009987	cellular process	19567321.	IDA	Process
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0030705	cytoskeleton-dependent intracellular transport	12090300.	TAS	Process
GO:0031625	ubiquitin protein ligase binding	21753002.	IPI	Function
GO:0032794	GTPase activating protein binding	-	IEA	Function
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0036464	cytoplasmic ribonucleoprotein granule	15121898.	IDA	Component
GO:0042267	natural killer cell mediated cytotoxicity	11120798.	NAS	Process
GO:0042288	MHC class I protein binding	11120798.	IDA	Function
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0044297	cell body	19567321.	IDA	Component
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0045121	membrane raft	-	IEA	Component
GO:0050807	regulation of synapse organization	-	IEA	Process
GO:0051225	spindle assembly	-	IEA	Process
GO:0051301	cell division	12090300.	TAS	Process
GO:0070062	extracellular exosome	12519789.21362503.23533145.	HDA	Component
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.