EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr9	92223381	Missense_Mutation	rs560795216	Y1173C	0.43
BLCA	chr9	92268283	Missense_Mutation	rs201564889	R441Q	0.3
BLCA	chr9	92288206	Missense_Mutation	novel	D66H	0.35	tRNA-synt_1g
BLCA	chr9	92256693	Missense_Mutation	novel	E708D	0.34
BLCA	chr9	92271609	Nonsense_Mutation	novel	S346*	0.34
BLCA	chr9	92222557	Silent	novel	R1223R	0.47
BLCA	chr9	92288214	Missense_Mutation	novel	T63K	0.53	tRNA-synt_1g
BLCA	chr9	92210715	3'UTR	novel		0.39
BRCA	chr9	92271047	Missense_Mutation	NA	L381F	0.33
BRCA	chr9	92263004	Silent	NA	F584F	0.34
BRCA	chr9	92222565	Missense_Mutation	novel	R1221G	0.12
BRCA	chr9	92265548	Silent	NA	V479V	0.2
BRCA	chr9	92269885	Missense_Mutation	novel	W435L	0.08
BRCA	chr9	92223370	Nonsense_Mutation	NA	Q1177*	0.38
BRCA	chr9	92250719	Missense_Mutation	rs367830465	R808H	0.3
BRCA	chr9	92229112	Silent	rs766580083	L1100L	0.12
BRCA	chr9	92268171	Splice_Region	rs748497606		0.43
BRCA	chr9	92250733	Silent	novel	Y803Y	0.1
BRCA	chr9	92240857	Missense_Mutation	NA	Q1094H	0.18
BRCA	chr9	92280779	Missense_Mutation	NA	V238I	0.29	tRNA-synt_1g
BRCA	chr9	92244999	Missense_Mutation	NA	T955R	0.18
BRCA	chr9	92260220	Frame_Shift_Ins	NA	*M601Nfs21**	0.11
BRCA	chr9	92250813	Missense_Mutation	novel	T777A	0.27
CESC	chr9	92240627	Intron	novel		0.22
CESC	chr9	92240838	Intron	NA		0.36
CHOL	chr9	92243223	Missense_Mutation	novel	R998L	0.5
COAD	chr9	92289298	Splice_Region	NA		0.27
COAD	chr9	92280802	Missense_Mutation	novel	L230R	0.23	tRNA-synt_1g
COAD	chr9	92293637	5'UTR	novel		0.14
COAD	chr9	92280883	Missense_Mutation	novel	D203A	0.4	tRNA-synt_1g
COAD	chr9	92260221	Frame_Shift_Del	novel	M601*	0.3
COAD	chr9	92223375	Missense_Mutation	NA	N1175S	0.2
COAD	chr9	92265098	Missense_Mutation	rs371250371	R511C	0.42
COAD	chr9	92269905	Silent	novel	R428R	0.05
COAD	chr9	92277882	Frame_Shift_Ins	NA	*L292Pfs3**	0.4	tRNA-synt_1g
COAD	chr9	92268275	Frame_Shift_Ins	novel	*R444Tfs11**	0.16
COAD	chr9	92293694	5'UTR	novel		0.16
COAD	chr9	92210870	Silent	rs777464643	P1242P	0.34
COAD	chr9	92278238	Missense_Mutation	novel	A265V	0.21	tRNA-synt_1g
COAD	chr9	92249906	Silent	novel	D856D	0.11
COAD	chr9	92287827	Nonsense_Mutation	NA	C120*	0.18	tRNA-synt_1g
COAD	chr9	92268274	Missense_Mutation	rs200389880	R444Q	0.24
DLBC	chr9	92258980	Silent	NA	S630S	0.23
ESCA	chr9	92247501	Silent	novel	G889G	0.17
ESCA	chr9	92293523	5'UTR	novel		0.3
ESCA	chr9	92280769	Missense_Mutation	novel	E241V	0.14	tRNA-synt_1g
ESCA	chr9	92247409	Missense_Mutation	novel	S920N	0.19
ESCA	chr9	92260221	Frame_Shift_Del	novel	M601*	0.33
GBM	chr9	92244963	Missense_Mutation	novel	A967V	0.4
GBM	chr9	92244964	Missense_Mutation	novel	A967S	0.41
GBM	chr9	92223465	Missense_Mutation	novel	L1145P	0.05
GBM	chr9	92288233	Missense_Mutation	novel	G57R	0.13	tRNA-synt_1g
GBM	chr9	92210815	Missense_Mutation	novel	D1261Y	0.17
GBM	chr9	92274432	Silent	rs370595725	F328F	0.45
GBM	chr9	92287862	Missense_Mutation	novel	A109T	0.69	tRNA-synt_1g
GBM	chr9	92262971	Splice_Region	novel	A595A	0.12
GBM	chr9	92269917	Silent	novel	D424D	0.1
GBM	chr9	92229022	Missense_Mutation	rs139893778	A1130T	0.61
GBM	chr9	92242158	Frame_Shift_Ins	novel	*T1058Nfs7**	0.48
GBM	chr9	92288207	Silent	novel	K65K	0.08
HNSC	chr9	92247387	Missense_Mutation	novel	F927L	0.32
HNSC	chr9	92280851	Nonsense_Mutation	novel	E214*	0.1	tRNA-synt_1g
HNSC	chr9	92264937	Silent	novel	T564T	0.19
HNSC	chr9	92242264	Missense_Mutation	novel	N1023Y	0.16
HNSC	chr9	92251878	Missense_Mutation	novel	N746S	0.18
HNSC	chr9	92242154	Missense_Mutation	novel	Q1059H	0.17
HNSC	chr9	92210752	3'UTR	novel		0.22
HNSC	chr9	92287791	Splice_Region	novel	K132K	0.15
HNSC	chr9	92265107	Missense_Mutation	novel	I508L	0.2
HNSC	chr9	92288140	Missense_Mutation	novel	H88N	0.47	tRNA-synt_1g
HNSC	chr9	92268204	Silent	novel	I467I	0.16
KIRC	chr9	92249917	Missense_Mutation	NA	I853F	0.17
KIRC	chr9	92249919	Missense_Mutation	NA	V852A	0.17
KIRC	chr9	92253402	Frame_Shift_Ins	novel	*L730Pfs11**	0.05
KIRC	chr9	92265033	Silent	NA	S532S	0.33
KIRC	chr9	92258982	Missense_Mutation	NA	S630T	0.22
KIRP	chr9	92265069	Silent	novel	I520I	0.39
LGG	chr9	92271547	Nonsense_Mutation	novel	G367*	0.07
LIHC	chr9	92258960	Missense_Mutation	novel	N637S	0.42
LIHC	chr9	92240946	Silent	novel	L1065L	0.31
LIHC	chr9	92244981	Frame_Shift_Del	novel	A959*	0.24
LUAD	chr9	92240856	Missense_Mutation	rs765025476	G1095S	0.33
LUAD	chr9	92210870	Silent	rs777464643	P1242P	0.51
LUAD	chr9	92242166	Missense_Mutation	novel	Q1055H	0.16
LUAD	chr9	92222602	Missense_Mutation	NA	Q1208H	0.24
LUAD	chr9	92223479	Silent	NA	N1140N	0.07
LUAD	chr9	92253450	Missense_Mutation	NA	Y714F	0.09
LUAD	chr9	92256789	Silent	NA	I676I	0.37
LUAD	chr9	92244963	Missense_Mutation	novel	A967V	0.17
LUAD	chr9	92293469	5'UTR	novel		0.25
LUAD	chr9	92210810	Silent	novel	F1262F	0.35
LUAD	chr9	92249940	Missense_Mutation	novel	Y845C	0.17
LUSC	chr9	92258860	Silent	novel	L670L	0.39
LUSC	chr9	92280881	Missense_Mutation	novel	P204S	0.15	tRNA-synt_1g
LUSC	chr9	92288224	Missense_Mutation	novel	L60I	0.7	tRNA-synt_1g
LUSC	chr9	92278255	Missense_Mutation	novel	M259I	0.62	tRNA-synt_1g
LUSC	chr9	92288250	Missense_Mutation	NA	T51I	0.35	tRNA-synt_1g
LUSC	chr9	92240890	Silent	novel	V1083V	0.45
LUSC	chr9	92229028	Missense_Mutation	NA	E1128Q	0.06
OV	chr9	92250757	Missense_Mutation	NA	D795E	0.42
OV	chr9	92247447	Silent	novel	G907G	0.3
OV	chr9	92247448	Missense_Mutation	novel	G907V	0.3
OV	chr9	92269913	Missense_Mutation	novel	L426V	0.08
OV	chr9	92229020	Silent	novel	A1130A	0.13
OV	chr9	92210622	3'UTR	novel		0.4
OV	chr9	92222643	Silent	novel	L1195L	0.08
OV	chr9	92271619	Missense_Mutation	rs200991915	R343W	0.42
OV	chr9	92229093	Missense_Mutation	novel	D1106G	0.13
PAAD	chr9	92256737	Missense_Mutation	novel	R694W	0.16
PAAD	chr9	92269963	Missense_Mutation	novel	Y409C	0.17
PAAD	chr9	92280871	Missense_Mutation	novel	F207C	0.04	tRNA-synt_1g
PRAD	chr9	92280844	Missense_Mutation	NA	E216G	0.32	tRNA-synt_1g
PRAD	chr9	92256728	Missense_Mutation	novel	L697M	0.44
READ	chr9	92293661	5'UTR	novel		0.39
READ	chr9	92242320	Missense_Mutation	novel	V1004G	0.05
READ	chr9	92265034	Missense_Mutation	novel	S532N	0.16
SARC	chr9	92250794	Missense_Mutation	novel	N783S	0.46
SKCM	chr9	92285830	Silent	NA	F163F	0.57
SKCM	chr9	92258907	Missense_Mutation	novel	P655S	0.32
SKCM	chr9	92256708	Silent	rs549039229	L703L	0.8
SKCM	chr9	92280860	Missense_Mutation	NA	P211S	0.29	tRNA-synt_1g
SKCM	chr9	92286538	Splice_Region	novel	V159V	0.89
SKCM	chr9	92258979	Missense_Mutation	novel	P631S	0.11
SKCM	chr9	92258980	Silent	NA	S630S	0.11
SKCM	chr9	92280829	Missense_Mutation	NA	V221A	0.96	tRNA-synt_1g
SKCM	chr9	92271594	Missense_Mutation	novel	P351L	0.42
SKCM	chr9	92240917	Silent	NA	S1074S	0.3
SKCM	chr9	92271646	Missense_Mutation	rs754788006	R334W	0.64
SKCM	chr9	92258889	Missense_Mutation	rs553833363	R661C	0.45
SKCM	chr9	92244980	Silent	NA	F961F	0.97
SKCM	chr9	92264972	Missense_Mutation	NA	P553S	0.89
SKCM	chr9	92258980	Silent	NA	S630S	0.29
SKCM	chr9	92264972	Missense_Mutation	NA	P553S	0.27
SKCM	chr9	92210773	3'UTR	rs765177636		0.14
SKCM	chr9	92222601	Missense_Mutation	NA	G1209S	0.43
SKCM	chr9	92242226	Silent	NA	T1035T	0.39
SKCM	chr9	92293486	5'UTR	novel		0.14
SKCM	chr9	92260191	Missense_Mutation	NA	P611S	0.16
SKCM	chr9	92240875	Silent	NA	C1088C	0.92
SKCM	chr9	92271594	Missense_Mutation	novel	P351L	0.84
SKCM	chr9	92229120	Missense_Mutation	novel	V1097E	0.52
SKCM	chr9	92229121	Missense_Mutation	novel	V1097I	0.49
STAD	chr9	92278208	Missense_Mutation	NA	I275T	0.19	tRNA-synt_1g
STAD	chr9	92247458	Missense_Mutation	NA	R904C	0.41
STAD	chr9	92242154	Missense_Mutation	novel	Q1059H	0.13
STAD	chr9	92271034	Nonsense_Mutation	rs140292751	R386*	0.25
STAD	chr9	92247511	Missense_Mutation	novel	N886T	0.4
STAD	chr9	92263010	Silent	NA	P582P	0.23
STAD	chr9	92210756	3'UTR	novel		0.09
STAD	chr9	92277872	Nonsense_Mutation	NA	Y295*	0.11	tRNA-synt_1g
STAD	chr9	92250206	Missense_Mutation	rs370194547	R838Q	0.15
STAD	chr9	92289364	Missense_Mutation	novel	L19W	0.25	tRNA-synt_1g
STAD	chr9	92268249	Silent	rs144681367	A452A	0.33
STAD	chr9	92222592	Missense_Mutation	NA	Y1212H	0.27
STAD	chr9	92268275	Nonsense_Mutation	rs745932544	R444*	0.31
STAD	chr9	92287807	Missense_Mutation	NA	Y127F	0.22	tRNA-synt_1g
STAD	chr9	92280772	Missense_Mutation	NA	P240L	0.16	tRNA-synt_1g
STAD	chr9	92245052	Silent	novel	G937G	0.19
STAD	chr9	92293447	5'UTR	novel		0.43
THCA	chr9	92268296	Missense_Mutation	NA	P437A	0.1
THYM	chr9	92287490	Intron	novel		0.29
UCEC	chr9	92243224	Missense_Mutation	rs746626200	R998C	0.25
UCEC	chr9	92293463	5'UTR	novel		0.29
UCEC	chr9	92240867	Missense_Mutation	NA	G1091D	0.23
UCEC	chr9	92247539	Nonsense_Mutation	rs770289543	R877*	0.39
UCEC	chr9	92250792	Missense_Mutation	NA	L784I	0.38
UCEC	chr9	92274483	Silent	NA	N311N	0.28
UCEC	chr9	92280841	Missense_Mutation	rs755986342	T217I	0.21	tRNA-synt_1g
UCEC	chr9	92245026	Missense_Mutation	rs375942375	R946H	0.49
UCEC	chr9	92271608	Silent	novel	S346S	0.08
UCEC	chr9	92271645	Missense_Mutation	rs150135423	R334Q	0.37
UCEC	chr9	92280801	Silent	novel	L230L	0.07
UCEC	chr9	92253376	Missense_Mutation	rs747311061	R739C	0.46
UCEC	chr9	92271646	Missense_Mutation	rs754788006	R334W	0.2
UCEC	chr9	92256730	Missense_Mutation	novel	I696T	0.39
UCEC	chr9	92280866	Missense_Mutation	novel	T209A	0.31	tRNA-synt_1g
UCEC	chr9	92287889	Missense_Mutation	novel	L100M	0.41	tRNA-synt_1g
UCEC	chr9	92249905	Missense_Mutation	novel	P857T	0.31
UCEC	chr9	92265098	Missense_Mutation	rs371250371	R511C	0.43
UCEC	chr9	92268253	Missense_Mutation	novel	D451G	0.54
UCEC	chr9	92289388	Missense_Mutation	novel	F11C	0.36
UCEC	chr9	92288175	Missense_Mutation	NA	G76E	0.24	tRNA-synt_1g
UCEC	chr9	92292580	Intron	novel		0.21
UCEC	chr9	92260183	Silent	NA	S613S	0.33
UCEC	chr9	92268189	Silent	NA	S472S	0.16
UCEC	chr9	92271567	Missense_Mutation	rs201999653	T360M	0.24
UCEC	chr9	92260163	Missense_Mutation	NA	A620V	0.23
UCEC	chr9	92260221	Frame_Shift_Del	novel	M601*	0.33
UCEC	chr9	92222667	Missense_Mutation	novel	L1187V	0.41
UCEC	chr9	92242242	Missense_Mutation	novel	T1030I	0.07
UCEC	chr9	92210666	3'UTR	novel		0.44
UCEC	chr9	92247379	Missense_Mutation	novel	T930I	0.28
UCEC	chr9	92271567	Missense_Mutation	rs201999653	T360M	0.43
UCEC	chr9	92274506	Missense_Mutation	rs765281263	A304T	0.51	tRNA-synt_1g
UCEC	chr9	92247468	Silent	novel	V900V	0.59
UCEC	chr9	92258991	Missense_Mutation	novel	L627M	0.42
UCEC	chr9	92288172	Missense_Mutation	novel	F77Y	0.09	tRNA-synt_1g
UCEC	chr9	92242242	Missense_Mutation	novel	T1030I	0.48
UCEC	chr9	92265038	Frame_Shift_Del	novel	*S530Rfs13**	0.48
UCEC	chr9	92271530	Splice_Region	novel		0.21
UCEC	chr9	92268274	Missense_Mutation	rs200389880	R444Q	0.35
UCEC	chr9	92288220	Missense_Mutation	rs776904169	A61V	0.31	tRNA-synt_1g
UCEC	chr9	92293529	5'UTR	NA		0.4
UCEC	chr9	92258891	Missense_Mutation	rs767768701	Y660C	0.37
UCEC	chr9	92247427	Missense_Mutation	rs77245714	T914M	0.29
UCEC	chr9	92285743	Silent	rs534075085	F192F	0.29
UCEC	chr9	92293601	5'UTR	novel		0.73
UCEC	chr9	92271654	Missense_Mutation	novel	E331V	0.14
UCEC	chr9	92247497	Missense_Mutation	rs753678164	R891W	0.35
UCEC	chr9	92210785	3'UTR	rs374104056		0.31
UCEC	chr9	92258997	Missense_Mutation	novel	L625V	0.39
UCEC	chr9	92260217	Missense_Mutation	novel	S602T	0.07
UCEC	chr9	92285743	Silent	rs534075085	F192F	0.36
UCEC	chr9	92247539	Nonsense_Mutation	rs770289543	R877*	0.57
UCEC	chr9	92287891	Missense_Mutation	NA	T99I	0.21	tRNA-synt_1g
UCEC	chr9	92260211	Missense_Mutation	rs780409825	R604Q	0.42
UCEC	chr9	92244997	Missense_Mutation	novel	G956C	0.08
UCEC	chr9	92274440	Missense_Mutation	novel	P326T	0.23	tRNA-synt_1g
UCEC	chr9	92274484	Missense_Mutation	novel	N311S	0.08	tRNA-synt_1g
UCEC	chr9	92210869	Frame_Shift_Del	novel	V1243*	0.22
UCEC	chr9	92242212	Missense_Mutation	novel	P1040L	0.38
UCEC	chr9	92280835	Missense_Mutation	novel	S219Y	0.37	tRNA-synt_1g
UCEC	chr9	92293503	5'UTR	novel		0.42
UCEC	chr9	92288212	Missense_Mutation	NA	I64V	0.19	tRNA-synt_1g
UCEC	chr9	92250823	Silent	novel	T773T	0.13
UCEC	chr9	92293479	5'UTR	novel		0.16
UCEC	chr9	92260156	Silent	NA	A622A	0.11
UCEC	chr9	92263016	Silent	novel	G580G	0.12
UCEC	chr9	92242242	Missense_Mutation	novel	T1030I	0.47
UCEC	chr9	92242175	Silent	novel	V1052V	0.4
UCEC	chr9	92250732	Missense_Mutation	novel	L804I	0.47
UCEC	chr9	92280787	Missense_Mutation	novel	A235D	0.44	tRNA-synt_1g

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3627	0.11788
CHOL	DEL	0.4722	0.067545
LAML	DEL	0.0209	0.24147
LIHC	DEL	0.2676	0.12467
PCPG	DEL	0.0556	0.13351
THCA	DEL	0.0401	0.24038
THYM	DEL	0.0163	0.022012
UCEC	DEL	0.2301	0.027215
UCS	DEL	0.5893	0.089783

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0021	Kaplan-Meier Survival Analysis
SARC	0.009	Kaplan-Meier Survival Analysis
MESO	0.018	Kaplan-Meier Survival Analysis
ACC	0.0006	Kaplan-Meier Survival Analysis
HNSC	0.0036	Kaplan-Meier Survival Analysis
BRCA	0.0047	Kaplan-Meier Survival Analysis
PCPG	0.037	Kaplan-Meier Survival Analysis
BLCA	0.0035	Kaplan-Meier Survival Analysis
CESC	0.023	Kaplan-Meier Survival Analysis
READ	0.022	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
UVM	0.004	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000196305 (Gene tree)
Gene ID: 3376
Gene Symbol: IARS
Alias: ILRS|IARS1
Full Name: isoleucyl-tRNA synthetase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 83,550 bases
Position: chr9:92,210,207-92,293,756
Accession: 5330
RBP type: canonical RBP
Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000406448	tRNA-synt_1g	PF09334.11	2e-14	1	1
ENSP00000364794	tRNA-synt_1g	PF09334.11	2.1e-14	1	1
ENSP00000378922	tRNA-synt_1g	PF09334.11	9.3e-07	1	1
ENSP00000415020	Anticodon_1	PF08264.13	2.4e-22	1	1
ENSP00000406448	Anticodon_1	PF08264.13	2.6e-22	1	1
ENSP00000364794	Anticodon_1	PF08264.13	2.7e-22	1	1
ENSP00000364794	tRNA-synt_1	PF00133.22	3.2e-252	1	1
ENSP00000406448	tRNA-synt_1	PF00133.22	3.2e-252	1	1
ENSP00000415020	tRNA-synt_1	PF00133.22	4.7e-208	1	1
ENSP00000378922	tRNA-synt_1	PF00133.22	4.8e-124	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12486008	An inserted region of leucyl-tRNA synthetase plays a critical role in group I intron splicing.	EMBO J	2002 Dec 16	Rho SB	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000498025	IARS-212	707	-	-	- (aa)	-	-
ENST00000447699	IARS-206	4186	-	ENSP00000415020	1152 (aa)	-	J3KR24
ENST00000474340	IARS-210	1748	-	-	- (aa)	-	-
ENST00000375627	IARS-201	697	-	ENSP00000364778	174 (aa)	-	Q5TCC6
ENST00000430417	IARS-204	414	-	ENSP00000387603	72 (aa)	-	Q5TCC9
ENST00000395554	IARS-203	1103	-	ENSP00000378922	330 (aa)	-	Q5TCD1
ENST00000472894	IARS-208	651	-	-	- (aa)	-	-
ENST00000490438	IARS-211	887	-	-	- (aa)	-	-
ENST00000443024	IARS-205	4341	-	ENSP00000406448	1242 (aa)	-	A0A0A0MSX9
ENST00000375643	IARS-202	4656	-	ENSP00000364794	1262 (aa)	-	P41252
ENST00000627121	IARS-213	4587	-	ENSP00000486469	174 (aa)	-	Q5TCC6
ENST00000473915	IARS-209	610	-	-	- (aa)	-	-
ENST00000467876	IARS-207	298	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000196305's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000196305	C-Reactive Protein	5.827e-005	19060910
ENSG00000196305	Respiratory Function Tests	4.4330000E-005	-
ENSG00000196305	Respiratory Function Tests	3.4980000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196305's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000196305	IARS	100	79.394	ENSAPOG00000002559	iars	98	77.028	Acanthochromis_polyacanthus
ENSG00000196305	IARS	100	93.030	ENSAMEG00000013415	IARS	99	90.808	Ailuropoda_melanoleuca
ENSG00000196305	IARS	98	75.704	ENSACIG00000018381	iars	99	73.975	Amphilophus_citrinellus
ENSG00000196305	IARS	100	75.749	ENSAOCG00000006976	iars	99	77.426	Amphiprion_ocellaris
ENSG00000196305	IARS	100	79.697	ENSAPEG00000005602	iars	99	77.269	Amphiprion_percula
ENSG00000196305	IARS	100	79.697	ENSATEG00000024989	iars	99	76.638	Anabas_testudineus
ENSG00000196305	IARS	100	84.242	ENSAPLG00000005750	IARS	99	81.646	Anas_platyrhynchos
ENSG00000196305	IARS	100	85.152	ENSACAG00000009212	IARS	99	81.028	Anolis_carolinensis
ENSG00000196305	IARS	100	97.273	ENSANAG00000035740	IARS	100	96.197	Aotus_nancymaae
ENSG00000196305	IARS	100	80.000	ENSACLG00000017656	iars	99	75.846	Astatotilapia_calliptera
ENSG00000196305	IARS	100	80.909	ENSAMXG00000036265	iars	99	75.908	Astyanax_mexicanus
ENSG00000196305	IARS	100	91.515	ENSBTAG00000000974	IARS	100	91.125	Bos_taurus
ENSG00000196305	IARS	99	62.918	WBGene00002152	iars-1	99	56.083	Caenorhabditis_elegans
ENSG00000196305	IARS	100	96.970	ENSCJAG00000020465	IARS	99	95.447	Callithrix_jacchus
ENSG00000196305	IARS	100	93.333	ENSCAFG00000002340	IARS	100	90.412	Canis_familiaris
ENSG00000196305	IARS	100	93.333	ENSCAFG00020009677	IARS	100	90.412	Canis_lupus_dingo
ENSG00000196305	IARS	100	91.521	ENSCHIG00000023719	IARS	100	91.521	Capra_hircus
ENSG00000196305	IARS	100	93.636	ENSTSYG00000001294	IARS	99	92.784	Carlito_syrichta
ENSG00000196305	IARS	97	85.747	ENSCAPG00000008012	IARS	92	85.747	Cavia_aperea
ENSG00000196305	IARS	100	92.121	ENSCPOG00000000819	IARS	99	89.215	Cavia_porcellus
ENSG00000196305	IARS	100	97.576	ENSCCAG00000022901	IARS	99	95.470	Cebus_capucinus
ENSG00000196305	IARS	100	98.182	ENSCATG00000044530	IARS	100	93.135	Cercocebus_atys
ENSG00000196305	IARS	88	100.000	ENSCLAG00000003319	IARS	97	100.000	Chinchilla_lanigera
ENSG00000196305	IARS	100	97.879	ENSCSAG00000007241	IARS	100	97.702	Chlorocebus_sabaeus
ENSG00000196305	IARS	88	92.105	ENSCHOG00000007264	IARS	87	92.105	Choloepus_hoffmanni
ENSG00000196305	IARS	100	83.939	ENSCPBG00000001174	IARS	99	82.463	Chrysemys_picta_bellii
ENSG00000196305	IARS	100	71.818	ENSCING00000002466	-	100	69.200	Ciona_intestinalis
ENSG00000196305	IARS	99	80.729	ENSCSAVG00000008078	-	94	80.729	Ciona_savignyi
ENSG00000196305	IARS	100	91.515	ENSCGRG00001023981	Iars	99	90.960	Cricetulus_griseus_chok1gshd
ENSG00000196305	IARS	100	91.515	ENSCGRG00000007869	Iars	99	90.960	Cricetulus_griseus_crigri
ENSG00000196305	IARS	100	79.394	ENSCSEG00000010191	iars	97	75.848	Cynoglossus_semilaevis
ENSG00000196305	IARS	100	80.000	ENSCVAG00000023077	-	95	78.421	Cyprinodon_variegatus
ENSG00000196305	IARS	100	76.970	ENSDARG00000007955	iars	99	74.115	Danio_rerio
ENSG00000196305	IARS	100	89.072	ENSDNOG00000019773	IARS	100	89.345	Dasypus_novemcinctus
ENSG00000196305	IARS	100	92.424	ENSDORG00000004383	Iars	99	91.594	Dipodomys_ordii
ENSG00000196305	IARS	99	66.667	FBgn0027086	IleRS	99	54.509	Drosophila_melanogaster
ENSG00000196305	IARS	74	89.937	ENSETEG00000004138	-	74	89.937	Echinops_telfairi
ENSG00000196305	IARS	100	66.061	ENSEBUG00000016686	iars	100	61.126	Eptatretus_burgeri
ENSG00000196305	IARS	100	94.545	ENSEASG00005009580	IARS	98	93.014	Equus_asinus_asinus
ENSG00000196305	IARS	100	94.545	ENSECAG00000023253	IARS	93	93.214	Equus_caballus
ENSG00000196305	IARS	85	94.224	ENSEEUG00000012427	IARS	85	94.224	Erinaceus_europaeus
ENSG00000196305	IARS	100	70.909	ENSELUG00000015636	iars	99	70.955	Esox_lucius
ENSG00000196305	IARS	100	93.636	ENSFCAG00000000817	IARS	100	91.680	Felis_catus
ENSG00000196305	IARS	100	83.333	ENSFALG00000010261	IARS	93	80.960	Ficedula_albicollis
ENSG00000196305	IARS	100	92.424	ENSFDAG00000010686	IARS	99	91.277	Fukomys_damarensis
ENSG00000196305	IARS	100	80.909	ENSFHEG00000015399	iars	99	76.401	Fundulus_heteroclitus
ENSG00000196305	IARS	100	78.182	ENSGMOG00000003632	iars	99	73.954	Gadus_morhua
ENSG00000196305	IARS	100	84.545	ENSGALG00000004813	IARS	99	82.149	Gallus_gallus
ENSG00000196305	IARS	100	80.909	ENSGAFG00000012832	iars	99	77.190	Gambusia_affinis
ENSG00000196305	IARS	100	79.697	ENSGACG00000007055	iars	99	79.290	Gasterosteus_aculeatus
ENSG00000196305	IARS	100	85.152	ENSGAGG00000017539	IARS	99	82.472	Gopherus_agassizii
ENSG00000196305	IARS	100	99.697	ENSGGOG00000010212	IARS	100	99.208	Gorilla_gorilla
ENSG00000196305	IARS	100	80.000	ENSHBUG00000010503	iars	97	76.717	Haplochromis_burtoni
ENSG00000196305	IARS	100	93.030	ENSHGLG00000011793	IARS	99	91.197	Heterocephalus_glaber_female
ENSG00000196305	IARS	84	77.098	ENSHGLG00100010624	-	97	76.824	Heterocephalus_glaber_male
ENSG00000196305	IARS	100	90.741	ENSHGLG00100019375	-	99	90.801	Heterocephalus_glaber_male
ENSG00000196305	IARS	100	79.394	ENSHCOG00000017482	iars	99	75.237	Hippocampus_comes
ENSG00000196305	IARS	100	79.394	ENSIPUG00000012333	iars	99	75.750	Ictalurus_punctatus
ENSG00000196305	IARS	100	93.636	ENSSTOG00000015173	IARS	100	93.582	Ictidomys_tridecemlineatus
ENSG00000196305	IARS	100	91.818	ENSJJAG00000012564	Iars	99	91.277	Jaculus_jaculus
ENSG00000196305	IARS	100	78.182	ENSKMAG00000011154	iars	99	75.770	Kryptolebias_marmoratus
ENSG00000196305	IARS	100	80.606	ENSLBEG00000016283	iars	99	76.480	Labrus_bergylta
ENSG00000196305	IARS	100	82.727	ENSLACG00000018913	IARS	100	80.095	Latimeria_chalumnae
ENSG00000196305	IARS	100	81.515	ENSLOCG00000013871	iars	99	77.804	Lepisosteus_oculatus
ENSG00000196305	IARS	100	91.818	ENSLAFG00000012996	IARS	99	91.515	Loxodonta_africana
ENSG00000196305	IARS	100	98.182	ENSMFAG00000033748	IARS	100	93.225	Macaca_fascicularis
ENSG00000196305	IARS	100	97.743	ENSMMUG00000004628	IARS	100	97.743	Macaca_mulatta
ENSG00000196305	IARS	100	97.879	ENSMNEG00000018792	IARS	100	97.781	Macaca_nemestrina
ENSG00000196305	IARS	100	93.582	ENSMLEG00000035022	IARS	100	93.582	Mandrillus_leucophaeus
ENSG00000196305	IARS	100	79.697	ENSMAMG00000014297	iars	98	76.551	Mastacembelus_armatus
ENSG00000196305	IARS	100	80.000	ENSMZEG00005013533	iars	99	75.846	Maylandia_zebra
ENSG00000196305	IARS	100	84.242	ENSMGAG00000004555	IARS	99	81.883	Meleagris_gallopavo
ENSG00000196305	IARS	100	91.515	ENSMAUG00000018695	Iars	99	90.801	Mesocricetus_auratus
ENSG00000196305	IARS	100	94.122	ENSMICG00000014286	IARS	99	94.132	Microcebus_murinus
ENSG00000196305	IARS	100	91.224	ENSMOCG00000022610	Iars	99	91.277	Microtus_ochrogaster
ENSG00000196305	IARS	99	75.988	ENSMMOG00000010432	iars	99	73.861	Mola_mola
ENSG00000196305	IARS	100	89.091	ENSMODG00000020876	IARS	99	84.298	Monodelphis_domestica
ENSG00000196305	IARS	100	80.606	ENSMALG00000008778	iars	99	76.480	Monopterus_albus
ENSG00000196305	IARS	100	91.818	MGP_CAROLIEiJ_G0018510	Iars	100	92.391	Mus_caroli
ENSG00000196305	IARS	100	92.121	ENSMUSG00000037851	Iars	100	92.391	Mus_musculus
ENSG00000196305	IARS	100	91.212	MGP_PahariEiJ_G0019576	Iars	100	92.391	Mus_pahari
ENSG00000196305	IARS	100	91.515	MGP_SPRETEiJ_G0019390	Iars	100	92.391	Mus_spretus
ENSG00000196305	IARS	100	94.242	ENSMPUG00000004835	IARS	100	87.738	Mustela_putorius_furo
ENSG00000196305	IARS	100	91.818	ENSMLUG00000015180	IARS	99	91.046	Myotis_lucifugus
ENSG00000196305	IARS	56	72.500	ENSNGAG00000001639	-	100	81.522	Nannospalax_galili
ENSG00000196305	IARS	100	91.818	ENSNGAG00000007880	-	97	90.818	Nannospalax_galili
ENSG00000196305	IARS	100	80.000	ENSNBRG00000022044	iars	99	76.480	Neolamprologus_brichardi
ENSG00000196305	IARS	100	98.390	ENSNLEG00000016253	IARS	99	98.414	Nomascus_leucogenys
ENSG00000196305	IARS	99	75.870	ENSMEUG00000011662	IARS	99	75.949	Notamacropus_eugenii
ENSG00000196305	IARS	85	90.541	ENSOPRG00000009618	-	76	100.000	Ochotona_princeps
ENSG00000196305	IARS	95	68.254	ENSODEG00000008400	-	98	72.086	Octodon_degus
ENSG00000196305	IARS	100	92.424	ENSODEG00000004404	-	99	88.827	Octodon_degus
ENSG00000196305	IARS	100	80.000	ENSONIG00000014366	iars	99	76.401	Oreochromis_niloticus
ENSG00000196305	IARS	94	82.841	ENSOANG00000000112	-	100	82.841	Ornithorhynchus_anatinus
ENSG00000196305	IARS	60	72.093	ENSOANG00000020510	-	79	90.909	Ornithorhynchus_anatinus
ENSG00000196305	IARS	100	93.559	ENSOCUG00000016888	IARS	100	93.423	Oryctolagus_cuniculus
ENSG00000196305	IARS	100	79.697	ENSORLG00000004747	iars	99	75.612	Oryzias_latipes
ENSG00000196305	IARS	100	71.212	ENSORLG00020018714	iars	99	69.528	Oryzias_latipes_hni
ENSG00000196305	IARS	100	79.394	ENSORLG00015014606	iars	99	75.533	Oryzias_latipes_hsok
ENSG00000196305	IARS	100	80.303	ENSOMEG00000020072	iars	99	75.691	Oryzias_melastigma
ENSG00000196305	IARS	100	94.545	ENSOGAG00000015426	IARS	99	92.948	Otolemur_garnettii
ENSG00000196305	IARS	100	91.515	ENSOARG00000008328	IARS	100	91.449	Ovis_aries
ENSG00000196305	IARS	100	99.762	ENSPPAG00000027754	IARS	100	99.762	Pan_paniscus
ENSG00000196305	IARS	100	93.333	ENSPPRG00000008953	IARS	100	91.601	Panthera_pardus
ENSG00000196305	IARS	100	90.972	ENSPTIG00000015464	IARS	100	90.972	Panthera_tigris_altaica
ENSG00000196305	IARS	100	99.697	ENSPTRG00000021108	IARS	100	99.648	Pan_troglodytes
ENSG00000196305	IARS	100	98.182	ENSPANG00000024723	IARS	100	93.315	Papio_anubis
ENSG00000196305	IARS	100	80.000	ENSPKIG00000025011	iars	99	75.257	Paramormyrops_kingsleyae
ENSG00000196305	IARS	100	83.333	ENSPSIG00000011011	IARS	99	81.186	Pelodiscus_sinensis
ENSG00000196305	IARS	97	72.539	ENSPMGG00000005379	iars	100	72.539	Periophthalmus_magnuspinnatus
ENSG00000196305	IARS	100	91.818	ENSPEMG00000012867	Iars	99	91.277	Peromyscus_maniculatus_bairdii
ENSG00000196305	IARS	60	80.402	ENSPMAG00000000527	-	100	80.402	Petromyzon_marinus
ENSG00000196305	IARS	100	88.182	ENSPCIG00000023807	IARS	92	82.688	Phascolarctos_cinereus
ENSG00000196305	IARS	100	80.909	ENSPFOG00000011883	iars	99	76.401	Poecilia_formosa
ENSG00000196305	IARS	100	81.212	ENSPLAG00000012010	iars	99	76.401	Poecilia_latipinna
ENSG00000196305	IARS	100	80.909	ENSPMEG00000018215	iars	99	76.401	Poecilia_mexicana
ENSG00000196305	IARS	100	80.303	ENSPREG00000006938	iars	99	76.243	Poecilia_reticulata
ENSG00000196305	IARS	100	95.246	ENSPPYG00000019374	IARS	100	95.246	Pongo_abelii
ENSG00000196305	IARS	99	84.770	ENSPCAG00000013215	IARS	99	84.615	Procavia_capensis
ENSG00000196305	IARS	100	94.847	ENSPCOG00000017998	IARS	99	94.845	Propithecus_coquereli
ENSG00000196305	IARS	100	87.273	ENSPVAG00000010269	IARS	93	91.116	Pteropus_vampyrus
ENSG00000196305	IARS	100	80.000	ENSPNYG00000019391	iars	99	76.638	Pundamilia_nyererei
ENSG00000196305	IARS	100	73.333	ENSPNAG00000008441	iars	99	74.152	Pygocentrus_nattereri
ENSG00000196305	IARS	100	91.818	ENSRNOG00000014616	Iars	99	90.801	Rattus_norvegicus
ENSG00000196305	IARS	100	91.818	ENSRNOG00000052977	LOC103690033	100	91.018	Rattus_norvegicus
ENSG00000196305	IARS	100	97.576	ENSRBIG00000038873	IARS	99	94.955	Rhinopithecus_bieti
ENSG00000196305	IARS	100	97.879	ENSRROG00000028942	IARS	100	97.861	Rhinopithecus_roxellana
ENSG00000196305	IARS	97	59.317	YBL076C	ILS1	98	54.210	Saccharomyces_cerevisiae
ENSG00000196305	IARS	100	92.478	ENSSBOG00000001596	IARS	100	96.125	Saimiri_boliviensis_boliviensis
ENSG00000196305	IARS	99	81.234	ENSSHAG00000000237	IARS	99	82.257	Sarcophilus_harrisii
ENSG00000196305	IARS	100	80.606	ENSSFOG00015001874	iars	99	73.539	Scleropages_formosus
ENSG00000196305	IARS	100	80.909	ENSSMAG00000013630	iars	99	75.848	Scophthalmus_maximus
ENSG00000196305	IARS	100	80.303	ENSSDUG00000016007	iars	99	77.014	Seriola_dumerili
ENSG00000196305	IARS	100	79.697	ENSSLDG00000003987	iars	99	76.322	Seriola_lalandi_dorsalis
ENSG00000196305	IARS	100	89.614	ENSSARG00000010543	IARS	99	89.453	Sorex_araneus
ENSG00000196305	IARS	99	80.899	ENSSPUG00000002467	IARS	98	80.899	Sphenodon_punctatus
ENSG00000196305	IARS	100	80.303	ENSSPAG00000020176	iars	99	76.559	Stegastes_partitus
ENSG00000196305	IARS	100	93.333	ENSSSCG00000008068	IARS	99	93.452	Sus_scrofa
ENSG00000196305	IARS	100	80.896	ENSTGUG00000004410	IARS	99	79.748	Taeniopygia_guttata
ENSG00000196305	IARS	100	79.697	ENSTRUG00000007056	iars	99	76.619	Takifugu_rubripes
ENSG00000196305	IARS	100	80.606	ENSTNIG00000014814	iars	99	76.540	Tetraodon_nigroviridis
ENSG00000196305	IARS	80	93.182	ENSTBEG00000014010	IARS	75	94.000	Tupaia_belangeri
ENSG00000196305	IARS	100	92.424	ENSTTRG00000008240	IARS	99	88.510	Tursiops_truncatus
ENSG00000196305	IARS	100	93.030	ENSUAMG00000013778	IARS	100	91.204	Ursus_americanus
ENSG00000196305	IARS	100	93.636	ENSUMAG00000015456	IARS	100	91.521	Ursus_maritimus
ENSG00000196305	IARS	100	93.333	ENSVPAG00000008524	IARS	99	83.914	Vicugna_pacos
ENSG00000196305	IARS	100	93.636	ENSVVUG00000004144	IARS	99	90.412	Vulpes_vulpes
ENSG00000196305	IARS	100	74.281	ENSXETG00000020903	iars	99	74.214	Xenopus_tropicalis
ENSG00000196305	IARS	100	80.909	ENSXMAG00000017562	iars	99	76.577	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	-	IEA	Function
GO:0001649	osteoblast differentiation	16210410.	HDA	Process
GO:0002161	aminoacyl-tRNA editing activity	-	IEA	Function
GO:0004822	isoleucine-tRNA ligase activity	21873635.	IBA	Function
GO:0004822	isoleucine-tRNA ligase activity	8052601.	IDA	Function
GO:0004822	isoleucine-tRNA ligase activity	-	TAS	Function
GO:0005515	protein binding	9556618.10913161.11142386.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	22424946.	IDA	Component
GO:0005829	cytosol	19289464.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	Process
GO:0006428	isoleucyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0006428	isoleucyl-tRNA aminoacylation	8052601.	IDA	Process
GO:0016020	membrane	16210410.19946888.	HDA	Component
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	19131329.	IDA	Component
GO:0051020	GTPase binding	24337748.	IPI	Function
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.