EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28182322	Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex.	Mol Oncol	2017 Apr	Weirich S	doi: 10.1002/1878-0261.12041
25666610	WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission.	J Biol Chem	2015 Apr 3	Bailey JK	doi: 10.1074/jbc.M114.623611
28042945	Minicircle-oriP-miR-31 as a Novel EBNA1-Specific miRNA Therapy Approach for Nasopharyngeal Carcinoma.	Hum Gene Ther	2017 May	Wu J	doi: 10.1089/hum.2016.136
25656485	Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation.	Sci Rep	2015 Feb 6	Chen X	doi: 10.1038/srep08293.
29125890	Up-regulated WDR5 promotes gastric cancer formation by induced cyclin D1 expression.	J Cell Biochem	2018 Apr	Sun W	doi: 10.1002/jcb.26491
26355959	WDR5 Expression Is Prognostic of Breast Cancer Outcome.	PLoS One	2015 Sep 10	Dai X	doi: 10.1371/journal.pone.0124964
24051437	Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells.	Nat Commun	2013	Yoshimaru T	doi: 10.1038/ncomms3443.
24793694	A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer.	Mol Cell	2014 May 22	Kim JY	doi: 10.1016/j.molcel.2014.03.043
19496786	Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer.	Cancer Sci	2009 Aug	Kim JW	doi: 10.1111/j.1349-7006.2009.01209.x
27147598	LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern.	Cancer Discov	2016 Jul	Sun TT	doi: 10.1158/2159-8290.CD-15-0921
28487115	lncRNA HOXD-AS1 Regulates Proliferation and Chemo-Resistance of Castration-Resistant Prostate Cancer via Recruiting WDR5.	Mol Ther	2017 Aug 2	Gu P	doi: 10.1016/j.ymthe.2017.04.016
29569374	Overexpression of WD repeat domain 5 associates with aggressive clinicopathological features and unfavorable prognosis in head neck squamous cell carcinoma.	J Oral Pathol Med	2018 May	Wu Y	doi: 10.1111/jop.12708
28555617	A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells.	Nat Commun	2017 May 30	Yoshimaru T	doi: 10.1038/ncomms15427.
30226578	Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration.	Oncol Rep	2018 Nov	Yao R	doi: 10.3892/or.2018.6669
29925347	WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage.	BMC Cancer	2018 Jun 20	Neilsen BK	doi: 10.1186/s12885-018-4580-6.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr9	134154502	Missense_Mutation	novel	S223Y	0.08	eIF2A
BLCA	chr9	134154506	Silent	novel	P224P	0.88
BRCA	chr9	134156535	Silent	NA	L282L	0.32
BRCA	chr9	134141947	Splice_Site	novel	X89_splice	0.34
BRCA	chr9	134148305	Silent	NA	D182D	0.11
BRCA	chr9	134157997	3'UTR	novel		0.24
CESC	chr9	134157894	Missense_Mutation	novel	D302E	0.25
CESC	chr9	134157937	Missense_Mutation	rs746477625	A317T	0.39
COAD	chr9	134154511	Missense_Mutation	novel	G226V	0.36	eIF2A
COAD	chr9	134156571	Silent	novel	V294V	0.36
COAD	chr9	134157948	Silent	novel	A320A	0.39
COAD	chr9	134148286	Splice_Site	NA	X177_splice	0.34
COAD	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.5	eIF2A
COAD	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.06	eIF2A
COAD	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.21	eIF2A
COAD	chr9	134140720	Silent	novel	P33P	0.06
COAD	chr9	134154523	Missense_Mutation	novel	L230P	0.14	eIF2A
COAD	chr9	134156563	Missense_Mutation	NA	E292Q	0.13
COAD	chr9	134142641	Silent	rs541927663	D150D	0.17
COAD	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.4	eIF2A
COAD	chr9	134158088	3'UTR	novel		0.23
COAD	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.51	eIF2A
GBM	chr9	134142647	Silent	rs749466002	S152S	0.17
HNSC	chr9	134151991	Nonsense_Mutation	novel	W198*	0.1	eIF2A
HNSC	chr9	134139904	Missense_Mutation	novel	E9D	0.3
KIRC	chr9	134142418	Missense_Mutation	novel	G147E	0.31	eIF2A
KIRC	chr9	134142377	Missense_Mutation	NA	F133L	0.28
KIRC	chr9	134158127	3'UTR	novel		0.2
KIRC	chr9	134141541	Silent	rs142853576	A74A	0.36
KIRP	chr9	134158051	3'UTR	novel		0.25
LAML	chr9	134155712	Missense_Mutation	novel	G254D	0.07
LGG	chr9	134155690	Splice_Region	novel		0.12
LIHC	chr9	134157940	Missense_Mutation	novel	S318P	0.19
LIHC	chr9	134154465	Frame_Shift_Ins	novel	*D211Vfs10**	0.05	eIF2A
LIHC	chr9	134154466	Splice_Region	novel	D211delinsEFFCF	0.02	eIF2A
LIHC	chr9	134157909	Silent	novel	T307T	0.3
LUAD	chr9	134142001	Nonsense_Mutation	NA	S106*	0.16
LUAD	chr9	134142415	Nonsense_Mutation	NA	S146*	0.12	eIF2A
LUAD	chr9	134139937	Silent	novel	S20S	0.18
LUAD	chr9	134139873	5'UTR	novel		0.31
LUAD	chr9	134139858	5'UTR	novel		0.06
OV	chr9	134157997	3'UTR	novel		0.14
PAAD	chr9	134154527	Silent	rs140708390	A231A	0.18
PAAD	chr9	134152030	Splice_Site	rs112881246	X211_splice	0.29
PRAD	chr9	134157973	Silent	novel	L329L	0.42
SKCM	chr9	134139876	5'UTR	novel		0.68
SKCM	chr9	134142374	Silent	NA	V132V	0.3
SKCM	chr9	134154511	Missense_Mutation	novel	G226D	0.37	eIF2A
SKCM	chr9	134148300	Missense_Mutation	novel	R181C	0.33	eIF2A
SKCM	chr9	134142703	Missense_Mutation	NA	S171L	0.42	eIF2A
SKCM	chr9	134158036	3'UTR	novel		0.63
STAD	chr9	134139937	Silent	rs745714490	S20S	0.44
STAD	chr9	134154475	Frame_Shift_Ins	rs780890680	*V217Rfs42**	0.37	eIF2A
STAD	chr9	134158025	3'UTR	novel		0.3
STAD	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.31	eIF2A
STAD	chr9	134156509	Missense_Mutation	novel	I274F	0.34
STAD	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.07	eIF2A
STAD	chr9	134142647	Silent	rs749466002	S152S	0.27
STAD	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.06	eIF2A
STAD	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.21	eIF2A
STAD	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.18	eIF2A
UCEC	chr9	134154475	Frame_Shift_Ins	rs780890680	*V217Rfs42**	0.39	eIF2A
UCEC	chr9	134140785	Missense_Mutation	rs375576421	P55L	0.43
UCEC	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.48	eIF2A
UCEC	chr9	134154484	Missense_Mutation	novel	V217A	0.42	eIF2A
UCEC	chr9	134158139	3'UTR	novel		0.5
UCEC	chr9	134154483	Missense_Mutation	rs200878397	V217M	0.19	eIF2A
UCEC	chr9	134155719	Silent	NA	K256K	0.53
UCEC	chr9	134157948	Silent	novel	A320A	0.53
UCEC	chr9	134139811	Intron	novel		0.38
UCEC	chr9	134140772	Missense_Mutation	novel	V51M	0.05
UCEC	chr9	134156523	Silent	NA	S278S	0.4
UCEC	chr9	134155719	Silent	NA	K256K	0.29
UCEC	chr9	134158013	3'UTR	rs767564127		0.29
UCEC	chr9	134142380	Silent	novel	C134C	0.04
UCEC	chr9	134139912	Missense_Mutation	NA	A12G	0.5
UCEC	chr9	134142642	Missense_Mutation	novel	E151K	0.44	eIF2A
UCEC	chr9	134155749	Missense_Mutation	novel	F266L	0.57
UCEC	chr9	134158037	3'UTR	novel		0.15
UCEC	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.38	eIF2A
UCEC	chr9	134154471	Missense_Mutation	novel	D213N	0.42	eIF2A
UCEC	chr9	134154471	Missense_Mutation	novel	D213N	0.28	eIF2A
UCEC	chr9	134139955	Silent	novel	S26S	0.68
UCEC	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.29	eIF2A
UCEC	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.45	eIF2A
UCEC	chr9	134156584	Missense_Mutation	novel	G299C	0.29
UCEC	chr9	134139907	Silent	rs756330692	T10T	0.4
UCEC	chr9	134156558	Missense_Mutation	rs200230802	T290M	0.32
UCEC	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.38	eIF2A
UCEC	chr9	134141952	Missense_Mutation	novel	I90V	0.32
UCEC	chr9	134156558	Missense_Mutation	rs200230802	T290M	0.37
UCEC	chr9	134142716	Silent	novel	S175S	0.29
UCEC	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.28	eIF2A
UCEC	chr9	134158013	3'UTR	rs767564127		0.22
UCEC	chr9	134142415	Nonsense_Mutation	novel	S146*	0.32	eIF2A
UCEC	chr9	134154506	Silent	rs763104397	P224P	0.53
UCEC	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.08	eIF2A
UCEC	chr9	134141958	Missense_Mutation	NA	D92N	0.23
UCEC	chr9	134148311	Silent	novel	S184S	0.13
UCEC	chr9	134139861	5'UTR	rs377606529		0.08
UCEC	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.32	eIF2A
UCEC	chr9	134157891	Splice_Site	novel	X302_splice	0.13
UCEC	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.4	eIF2A
UCEC	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.51	eIF2A
UCEC	chr9	134158081	3'UTR	novel		0.26
UCEC	chr9	134142011	Missense_Mutation	novel	K109N	0.08
UCEC	chr9	134139867	5'UTR	novel		0.21
UCEC	chr9	134141553	Missense_Mutation	novel	K78N	0.28
UCEC	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.36	eIF2A
UCEC	chr9	134154476	Frame_Shift_Del	NA	*V217Cfs4**	0.45	eIF2A
UCEC	chr9	134139902	Missense_Mutation	novel	E9K	0.44
UCEC	chr9	134142423	Splice_Site	novel	X148_splice	0.33
UCEC	chr9	134154483	Missense_Mutation	rs200878397	V217M	0.38	eIF2A

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2056	0.070727
LAML	DEL	0.0052	0.24147
LGG	AMP	0.0585	0.21332
LIHC	DEL	0.2432	0.12467
OV	DEL	0.5527	2.9521e-06
SARC	DEL	0.2179	0.00032085
THCA	DEL	0.0401	0.24038
THYM	DEL	0.0163	0.022012
UCEC	DEL	0.2189	0.0022334
UCS	DEL	0.5893	0.089783

Survival Analysis

Cancer	P-value	Q-value
STAD	0.0079	Kaplan-Meier Survival Analysis
SARC	0.013	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
UCS	0.0066	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
PRAD	0.044	Kaplan-Meier Survival Analysis
PAAD	0.00017	Kaplan-Meier Survival Analysis
LAML	0.019	Kaplan-Meier Survival Analysis
LIHC	0.016	Kaplan-Meier Survival Analysis

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000196363 (Gene tree)
Gene ID: 11091
Gene Symbol: WDR5
Alias: SWD3|CFAP89
Full Name: WD repeat domain 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 24,608 bases
Position: chr9:134,135,365-134,159,972
Accession: 12757
RBP type: canonical RBP
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000351446	eIF2A	PF08662.11	1.6e-11	1	2
ENSP00000351446	eIF2A	PF08662.11	1.6e-11	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24521543	Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency.	Elife	2014 Feb 12	Yang YW	doi: 10.7554/eLife.02046.
29754779	A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis.	Cell Stem Cell	2018 Jun 1	Guo X	doi: 10.1016/j.stem.2018.04.013

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000608937	WDR5-203	705	-	ENSP00000477000	56 (aa)	-	V9GYQ5
ENST00000358625	WDR5-201	3151	XM_005272163	ENSP00000351446	334 (aa)	XP_005272220	P61964
ENST00000608739	WDR5-202	577	-	ENSP00000477449	96 (aa)	-	V9GZ59

Gene Model

Click here to download ENSG00000196363's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04934	Cushing syndrome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000196363	rs28603051	9	134143828	A	Cerebrospinal fluid t-tau levels in normal cognition	29274321	[0.29-0.69] unit increase	0.49	EFO_0004760
ENSG00000196363	rs11556391	9	134158857	?	Waist-hip ratio	30595370			EFO_0004343

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196363's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000196363	WDR5	89	39.506	ENSG00000140395	WDR61	98	40.397
ENSG00000196363	WDR5	94	31.613	ENSG00000183751	TBL3	73	31.613

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000196363	WDR5	99	94.864	ENSAPOG00000017322	wdr5	97	94.864	Acanthochromis_polyacanthus
ENSG00000196363	WDR5	100	100.000	ENSAMEG00000011179	WDR5	100	100.000	Ailuropoda_melanoleuca
ENSG00000196363	WDR5	99	83.784	ENSAMEG00000019768	WDR5B	99	83.784	Ailuropoda_melanoleuca
ENSG00000196363	WDR5	100	92.515	ENSACIG00000001424	wdr5	100	92.515	Amphilophus_citrinellus
ENSG00000196363	WDR5	100	94.910	ENSAOCG00000002553	wdr5	100	94.910	Amphiprion_ocellaris
ENSG00000196363	WDR5	100	94.910	ENSAPEG00000015385	wdr5	100	94.910	Amphiprion_percula
ENSG00000196363	WDR5	100	94.910	ENSATEG00000001927	wdr5	100	94.910	Anabas_testudineus
ENSG00000196363	WDR5	100	92.515	ENSATEG00000015802	-	100	93.413	Anabas_testudineus
ENSG00000196363	WDR5	100	89.820	ENSAPLG00000014714	WDR5B	100	89.820	Anas_platyrhynchos
ENSG00000196363	WDR5	100	96.108	ENSACAG00000003103	WDR5B	100	96.108	Anolis_carolinensis
ENSG00000196363	WDR5	99	84.384	ENSANAG00000031504	WDR5B	99	84.384	Aotus_nancymaae
ENSG00000196363	WDR5	99	100.000	ENSANAG00000015577	WDR5	94	100.000	Aotus_nancymaae
ENSG00000196363	WDR5	100	94.910	ENSACLG00000026429	wdr5	100	94.910	Astatotilapia_calliptera
ENSG00000196363	WDR5	100	95.808	ENSAMXG00000031828	wdr5	100	95.808	Astyanax_mexicanus
ENSG00000196363	WDR5	100	90.120	ENSAMXG00000007741	-	100	90.120	Astyanax_mexicanus
ENSG00000196363	WDR5	100	100.000	ENSBTAG00000047031	WDR5	100	100.000	Bos_taurus
ENSG00000196363	WDR5	99	84.639	ENSBTAG00000054326	WDR5B	83	84.639	Bos_taurus
ENSG00000196363	WDR5	99	84.084	ENSCJAG00000022130	WDR5B	99	84.084	Callithrix_jacchus
ENSG00000196363	WDR5	100	100.000	ENSCJAG00000010123	WDR5	100	100.000	Callithrix_jacchus
ENSG00000196363	WDR5	100	85.030	ENSCAFG00000011894	WDR5B	100	85.030	Canis_familiaris
ENSG00000196363	WDR5	100	100.000	ENSCAFG00000019830	WDR5	100	100.000	Canis_familiaris
ENSG00000196363	WDR5	100	84.431	ENSCAFG00020005756	WDR5B	99	84.431	Canis_lupus_dingo
ENSG00000196363	WDR5	100	100.000	ENSCAFG00020024847	WDR5	100	100.000	Canis_lupus_dingo
ENSG00000196363	WDR5	99	84.802	ENSCHIG00000015357	WDR5B	99	84.802	Capra_hircus
ENSG00000196363	WDR5	100	100.000	ENSCHIG00000023578	WDR5	100	100.000	Capra_hircus
ENSG00000196363	WDR5	89	72.868	ENSTSYG00000030519	WDR5	86	76.357	Carlito_syrichta
ENSG00000196363	WDR5	100	100.000	ENSCAPG00000006599	WDR5	100	100.000	Cavia_aperea
ENSG00000196363	WDR5	96	82.919	ENSCPOG00000005713	-	99	82.919	Cavia_porcellus
ENSG00000196363	WDR5	100	100.000	ENSCPOG00000014790	WDR5	100	100.000	Cavia_porcellus
ENSG00000196363	WDR5	93	81.090	ENSCPOG00000031984	-	98	81.090	Cavia_porcellus
ENSG00000196363	WDR5	100	100.000	ENSCCAG00000027270	WDR5	100	100.000	Cebus_capucinus
ENSG00000196363	WDR5	99	84.685	ENSCCAG00000000075	WDR5B	99	84.685	Cebus_capucinus
ENSG00000196363	WDR5	99	84.384	ENSCATG00000002794	WDR5B	99	84.384	Cercocebus_atys
ENSG00000196363	WDR5	100	100.000	ENSCATG00000038092	WDR5	100	100.000	Cercocebus_atys
ENSG00000196363	WDR5	100	100.000	ENSCLAG00000006850	WDR5	100	100.000	Chinchilla_lanigera
ENSG00000196363	WDR5	96	82.609	ENSCLAG00000017883	WDR5B	99	82.609	Chinchilla_lanigera
ENSG00000196363	WDR5	99	84.685	ENSCSAG00000018716	WDR5B	99	84.685	Chlorocebus_sabaeus
ENSG00000196363	WDR5	100	100.000	ENSCSAG00000015584	WDR5	100	100.000	Chlorocebus_sabaeus
ENSG00000196363	WDR5	99	84.084	ENSCHOG00000004523	WDR5B	99	84.084	Choloepus_hoffmanni
ENSG00000196363	WDR5	100	96.707	ENSCPBG00000021091	WDR5B	100	96.707	Chrysemys_picta_bellii
ENSG00000196363	WDR5	97	86.728	ENSCING00000006958	-	90	86.728	Ciona_intestinalis
ENSG00000196363	WDR5	96	87.267	ENSCSAVG00000003310	-	99	82.019	Ciona_savignyi
ENSG00000196363	WDR5	100	100.000	ENSCANG00000041019	WDR5	100	100.000	Colobus_angolensis_palliatus
ENSG00000196363	WDR5	99	84.985	ENSCANG00000018938	WDR5B	99	84.985	Colobus_angolensis_palliatus
ENSG00000196363	WDR5	100	100.000	ENSCGRG00001019447	Wdr5	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000196363	WDR5	100	81.437	ENSCGRG00001013271	Wdr5b	100	81.437	Cricetulus_griseus_chok1gshd
ENSG00000196363	WDR5	100	81.437	ENSCGRG00000018576	Wdr5b	100	81.437	Cricetulus_griseus_crigri
ENSG00000196363	WDR5	100	100.000	ENSCGRG00000000270	Wdr5	100	100.000	Cricetulus_griseus_crigri
ENSG00000196363	WDR5	100	91.317	ENSCSEG00000008139	-	100	91.916	Cynoglossus_semilaevis
ENSG00000196363	WDR5	100	92.814	ENSCSEG00000005130	wdr5	100	92.814	Cynoglossus_semilaevis
ENSG00000196363	WDR5	100	94.611	ENSCVAG00000016360	wdr5	100	94.611	Cyprinodon_variegatus
ENSG00000196363	WDR5	100	95.808	ENSDARG00000016903	wdr5	100	95.808	Danio_rerio
ENSG00000196363	WDR5	100	99.701	ENSDNOG00000025013	WDR5	98	99.701	Dasypus_novemcinctus
ENSG00000196363	WDR5	97	82.769	ENSDNOG00000005558	WDR5B	98	82.769	Dasypus_novemcinctus
ENSG00000196363	WDR5	100	100.000	ENSDORG00000015010	Wdr5	100	100.000	Dipodomys_ordii
ENSG00000196363	WDR5	99	83.434	ENSDORG00000003169	Wdr5b	99	83.434	Dipodomys_ordii
ENSG00000196363	WDR5	90	56.623	FBgn0034274	CG10931	87	56.623	Drosophila_melanogaster
ENSG00000196363	WDR5	91	94.719	FBgn0040066	wds	88	91.223	Drosophila_melanogaster
ENSG00000196363	WDR5	94	81.470	ENSETEG00000017615	WDR5B	96	81.470	Echinops_telfairi
ENSG00000196363	WDR5	100	91.667	ENSEBUG00000004448	wdr5	100	91.667	Eptatretus_burgeri
ENSG00000196363	WDR5	97	83.692	ENSEASG00005015470	WDR5B	88	83.692	Equus_asinus_asinus
ENSG00000196363	WDR5	100	100.000	ENSEASG00005010670	WDR5	100	99.701	Equus_asinus_asinus
ENSG00000196363	WDR5	100	100.000	ENSECAG00000017389	WDR5	100	100.000	Equus_caballus
ENSG00000196363	WDR5	99	83.183	ENSEEUG00000002990	WDR5B	99	83.183	Erinaceus_europaeus
ENSG00000196363	WDR5	100	95.808	ENSELUG00000017301	WDR5	100	95.808	Esox_lucius
ENSG00000196363	WDR5	99	84.685	ENSFCAG00000005778	WDR5B	99	84.685	Felis_catus
ENSG00000196363	WDR5	100	100.000	ENSFCAG00000005712	WDR5	100	100.000	Felis_catus
ENSG00000196363	WDR5	100	97.006	ENSFALG00000001624	WDR5B	100	97.006	Ficedula_albicollis
ENSG00000196363	WDR5	100	100.000	ENSFDAG00000007174	WDR5	100	100.000	Fukomys_damarensis
ENSG00000196363	WDR5	94	84.345	ENSFDAG00000019178	WDR5B	97	84.345	Fukomys_damarensis
ENSG00000196363	WDR5	100	94.611	ENSFHEG00000014661	wdr5	100	94.611	Fundulus_heteroclitus
ENSG00000196363	WDR5	99	90.691	ENSGMOG00000016463	-	100	90.691	Gadus_morhua
ENSG00000196363	WDR5	100	93.713	ENSGMOG00000014479	wdr5	100	93.713	Gadus_morhua
ENSG00000196363	WDR5	100	97.006	ENSGALG00000002659	WDR5	100	97.006	Gallus_gallus
ENSG00000196363	WDR5	100	86.527	ENSGAFG00000003655	wdr5	100	86.527	Gambusia_affinis
ENSG00000196363	WDR5	100	94.012	ENSGACG00000018182	wdr5	96	98.058	Gasterosteus_aculeatus
ENSG00000196363	WDR5	100	96.707	ENSGAGG00000010128	WDR5B	100	96.707	Gopherus_agassizii
ENSG00000196363	WDR5	99	84.685	ENSGGOG00000003266	WDR5B	99	84.685	Gorilla_gorilla
ENSG00000196363	WDR5	100	100.000	ENSGGOG00000004997	WDR5	100	100.000	Gorilla_gorilla
ENSG00000196363	WDR5	100	94.910	ENSHBUG00000012552	wdr5	100	94.910	Haplochromis_burtoni
ENSG00000196363	WDR5	100	100.000	ENSHGLG00000013396	WDR5	100	99.701	Heterocephalus_glaber_female
ENSG00000196363	WDR5	94	84.345	ENSHGLG00000001717	WDR5B	97	84.345	Heterocephalus_glaber_female
ENSG00000196363	WDR5	94	84.345	ENSHGLG00100014917	WDR5B	97	84.345	Heterocephalus_glaber_male
ENSG00000196363	WDR5	100	100.000	ENSHGLG00100010259	WDR5	100	99.701	Heterocephalus_glaber_male
ENSG00000196363	WDR5	100	94.311	ENSHCOG00000013287	wdr5	100	94.311	Hippocampus_comes
ENSG00000196363	WDR5	100	94.910	ENSIPUG00000012532	wdr5	100	94.910	Ictalurus_punctatus
ENSG00000196363	WDR5	99	85.152	ENSSTOG00000027025	WDR5B	99	85.152	Ictidomys_tridecemlineatus
ENSG00000196363	WDR5	100	100.000	ENSSTOG00000015899	WDR5	100	100.000	Ictidomys_tridecemlineatus
ENSG00000196363	WDR5	95	82.704	ENSJJAG00000000297	Wdr5b	97	82.704	Jaculus_jaculus
ENSG00000196363	WDR5	100	100.000	ENSJJAG00000024197	Wdr5	100	100.000	Jaculus_jaculus
ENSG00000196363	WDR5	100	94.611	ENSKMAG00000016691	wdr5	100	94.611	Kryptolebias_marmoratus
ENSG00000196363	WDR5	100	91.617	ENSLBEG00000008771	-	100	92.216	Labrus_bergylta
ENSG00000196363	WDR5	100	91.617	ENSLBEG00000022445	wdr5	100	91.617	Labrus_bergylta
ENSG00000196363	WDR5	100	97.904	ENSLACG00000018863	WDR5B	100	97.904	Latimeria_chalumnae
ENSG00000196363	WDR5	100	96.108	ENSLOCG00000004568	wdr5	100	96.108	Lepisosteus_oculatus
ENSG00000196363	WDR5	99	83.183	ENSLAFG00000016063	WDR5B	99	83.183	Loxodonta_africana
ENSG00000196363	WDR5	100	100.000	ENSLAFG00000011192	WDR5	100	95.429	Loxodonta_africana
ENSG00000196363	WDR5	99	84.685	ENSMFAG00000026379	WDR5B	99	84.685	Macaca_fascicularis
ENSG00000196363	WDR5	100	100.000	ENSMFAG00000039367	WDR5	100	100.000	Macaca_fascicularis
ENSG00000196363	WDR5	100	100.000	ENSMMUG00000014159	WDR5	100	100.000	Macaca_mulatta
ENSG00000196363	WDR5	99	84.685	ENSMMUG00000016378	WDR5B	99	84.685	Macaca_mulatta
ENSG00000196363	WDR5	100	100.000	ENSMNEG00000044571	WDR5	100	100.000	Macaca_nemestrina
ENSG00000196363	WDR5	99	84.685	ENSMNEG00000018966	WDR5B	99	84.685	Macaca_nemestrina
ENSG00000196363	WDR5	100	100.000	ENSMLEG00000032338	WDR5	100	100.000	Mandrillus_leucophaeus
ENSG00000196363	WDR5	99	84.685	ENSMLEG00000027036	WDR5B	99	84.685	Mandrillus_leucophaeus
ENSG00000196363	WDR5	100	95.210	ENSMAMG00000003827	wdr5	100	95.210	Mastacembelus_armatus
ENSG00000196363	WDR5	100	93.114	ENSMAMG00000019389	-	100	93.114	Mastacembelus_armatus
ENSG00000196363	WDR5	100	94.910	ENSMZEG00005015903	wdr5	100	94.910	Maylandia_zebra
ENSG00000196363	WDR5	100	96.707	ENSMGAG00000006913	WDR5B	100	96.707	Meleagris_gallopavo
ENSG00000196363	WDR5	100	81.437	ENSMAUG00000007468	Wdr5b	100	81.437	Mesocricetus_auratus
ENSG00000196363	WDR5	100	100.000	ENSMAUG00000013154	Wdr5	100	100.000	Mesocricetus_auratus
ENSG00000196363	WDR5	100	100.000	ENSMICG00000008085	WDR5	100	100.000	Microcebus_murinus
ENSG00000196363	WDR5	99	85.886	ENSMICG00000049311	WDR5B	99	85.886	Microcebus_murinus
ENSG00000196363	WDR5	100	100.000	ENSMOCG00000013826	Wdr5	100	100.000	Microtus_ochrogaster
ENSG00000196363	WDR5	100	94.012	ENSMMOG00000011606	wdr5	100	94.012	Mola_mola
ENSG00000196363	WDR5	100	87.608	ENSMMOG00000021007	-	100	88.473	Mola_mola
ENSG00000196363	WDR5	100	94.611	ENSMODG00000025415	-	100	94.611	Monodelphis_domestica
ENSG00000196363	WDR5	100	91.617	ENSMODG00000023955	-	100	91.617	Monodelphis_domestica
ENSG00000196363	WDR5	99	67.069	ENSMODG00000000893	-	99	67.069	Monodelphis_domestica
ENSG00000196363	WDR5	100	92.814	ENSMODG00000013131	-	100	92.814	Monodelphis_domestica
ENSG00000196363	WDR5	100	93.114	ENSMALG00000002309	-	100	94.012	Monopterus_albus
ENSG00000196363	WDR5	100	94.611	ENSMALG00000005423	wdr5	100	94.611	Monopterus_albus
ENSG00000196363	WDR5	100	79.641	MGP_CAROLIEiJ_G0020710	Wdr5b	100	79.641	Mus_caroli
ENSG00000196363	WDR5	100	100.000	MGP_CAROLIEiJ_G0023343	Wdr5	100	100.000	Mus_caroli
ENSG00000196363	WDR5	100	100.000	ENSMUSG00000026917	Wdr5	100	100.000	Mus_musculus
ENSG00000196363	WDR5	100	79.042	ENSMUSG00000034379	Wdr5b	100	79.042	Mus_musculus
ENSG00000196363	WDR5	100	80.240	MGP_PahariEiJ_G0016413	Wdr5b	100	80.240	Mus_pahari
ENSG00000196363	WDR5	100	100.000	MGP_PahariEiJ_G0024800	Wdr5	100	100.000	Mus_pahari
ENSG00000196363	WDR5	100	100.000	MGP_SPRETEiJ_G0024260	Wdr5	100	100.000	Mus_spretus
ENSG00000196363	WDR5	100	79.641	MGP_SPRETEiJ_G0021608	Wdr5b	100	79.641	Mus_spretus
ENSG00000196363	WDR5	99	83.483	ENSMPUG00000018896	WDR5B	99	83.483	Mustela_putorius_furo
ENSG00000196363	WDR5	100	100.000	ENSMPUG00000012184	WDR5	100	100.000	Mustela_putorius_furo
ENSG00000196363	WDR5	99	82.883	ENSMLUG00000000949	WDR5B	99	82.883	Myotis_lucifugus
ENSG00000196363	WDR5	100	99.701	ENSMLUG00000002236	WDR5	100	99.701	Myotis_lucifugus
ENSG00000196363	WDR5	97	82.663	ENSNGAG00000013754	Wdr5b	98	82.663	Nannospalax_galili
ENSG00000196363	WDR5	100	100.000	ENSNGAG00000013503	Wdr5	100	100.000	Nannospalax_galili
ENSG00000196363	WDR5	99	84.985	ENSNLEG00000018651	WDR5B	99	84.985	Nomascus_leucogenys
ENSG00000196363	WDR5	100	100.000	ENSNLEG00000013472	-	100	72.455	Nomascus_leucogenys
ENSG00000196363	WDR5	100	90.120	ENSMEUG00000003879	-	100	90.120	Notamacropus_eugenii
ENSG00000196363	WDR5	88	83.959	ENSOPRG00000016841	-	99	83.959	Ochotona_princeps
ENSG00000196363	WDR5	94	83.492	ENSODEG00000019471	WDR5B	97	83.492	Octodon_degus
ENSG00000196363	WDR5	100	99.401	ENSODEG00000015612	-	100	99.401	Octodon_degus
ENSG00000196363	WDR5	100	94.910	ENSONIG00000013074	wdr5	100	94.910	Oreochromis_niloticus
ENSG00000196363	WDR5	100	97.904	ENSOANG00000003913	WDR5B	100	97.904	Ornithorhynchus_anatinus
ENSG00000196363	WDR5	100	94.311	ENSORLG00000012185	wdr5	99	94.311	Oryzias_latipes
ENSG00000196363	WDR5	100	94.311	ENSORLG00020008218	wdr5	99	94.311	Oryzias_latipes_hni
ENSG00000196363	WDR5	100	94.311	ENSORLG00015022359	wdr5	99	94.311	Oryzias_latipes_hsok
ENSG00000196363	WDR5	100	94.311	ENSOMEG00000019366	wdr5	99	94.311	Oryzias_melastigma
ENSG00000196363	WDR5	100	99.401	ENSOGAG00000008960	WDR5	100	99.401	Otolemur_garnettii
ENSG00000196363	WDR5	99	84.940	ENSOGAG00000033502	WDR5B	99	84.940	Otolemur_garnettii
ENSG00000196363	WDR5	96	86.250	ENSOARG00000001983	WDR5B	97	86.250	Ovis_aries
ENSG00000196363	WDR5	100	100.000	ENSOARG00000015927	-	100	84.364	Ovis_aries
ENSG00000196363	WDR5	100	100.000	ENSPPAG00000030638	WDR5	100	100.000	Pan_paniscus
ENSG00000196363	WDR5	99	84.985	ENSPPAG00000023737	WDR5B	99	84.985	Pan_paniscus
ENSG00000196363	WDR5	99	84.985	ENSPPRG00000018618	WDR5B	99	84.985	Panthera_pardus
ENSG00000196363	WDR5	100	100.000	ENSPPRG00000001820	WDR5	100	100.000	Panthera_pardus
ENSG00000196363	WDR5	99	84.985	ENSPTIG00000009752	WDR5B	99	84.985	Panthera_tigris_altaica
ENSG00000196363	WDR5	100	100.000	ENSPTIG00000011250	WDR5	100	99.401	Panthera_tigris_altaica
ENSG00000196363	WDR5	100	100.000	ENSPTRG00000023653	WDR5	100	100.000	Pan_troglodytes
ENSG00000196363	WDR5	99	84.985	ENSPTRG00000030152	WDR5B	99	84.985	Pan_troglodytes
ENSG00000196363	WDR5	99	84.685	ENSPANG00000015873	WDR5B	99	84.685	Papio_anubis
ENSG00000196363	WDR5	100	100.000	ENSPANG00000026103	WDR5	100	100.000	Papio_anubis
ENSG00000196363	WDR5	100	95.808	ENSPKIG00000018481	-	100	95.808	Paramormyrops_kingsleyae
ENSG00000196363	WDR5	100	94.910	ENSPKIG00000008600	wdr5	100	94.910	Paramormyrops_kingsleyae
ENSG00000196363	WDR5	100	96.707	ENSPSIG00000011864	WDR5B	100	96.707	Pelodiscus_sinensis
ENSG00000196363	WDR5	100	94.311	ENSPMGG00000023444	wdr5	100	94.311	Periophthalmus_magnuspinnatus
ENSG00000196363	WDR5	100	80.539	ENSPEMG00000004447	Wdr5b	100	80.539	Peromyscus_maniculatus_bairdii
ENSG00000196363	WDR5	100	100.000	ENSPEMG00000019087	Wdr5	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000196363	WDR5	100	97.904	ENSPCIG00000003893	-	100	97.904	Phascolarctos_cinereus
ENSG00000196363	WDR5	100	91.916	ENSPCIG00000025131	-	100	91.916	Phascolarctos_cinereus
ENSG00000196363	WDR5	100	94.611	ENSPLAG00000004502	wdr5	100	94.611	Poecilia_latipinna
ENSG00000196363	WDR5	100	94.611	ENSPMEG00000002321	wdr5	100	94.611	Poecilia_mexicana
ENSG00000196363	WDR5	100	94.611	ENSPMEG00000006433	-	100	94.611	Poecilia_mexicana
ENSG00000196363	WDR5	99	93.750	ENSPREG00000022222	wdr5	99	93.750	Poecilia_reticulata
ENSG00000196363	WDR5	99	84.685	ENSPPYG00000013484	WDR5B	99	84.685	Pongo_abelii
ENSG00000196363	WDR5	100	91.667	ENSPCAG00000013476	WDR5	100	79.734	Procavia_capensis
ENSG00000196363	WDR5	100	100.000	ENSPCOG00000026797	WDR5	100	100.000	Propithecus_coquereli
ENSG00000196363	WDR5	99	85.285	ENSPCOG00000003115	WDR5B	99	85.285	Propithecus_coquereli
ENSG00000196363	WDR5	100	99.102	ENSPVAG00000001666	WDR5	100	99.102	Pteropus_vampyrus
ENSG00000196363	WDR5	100	94.910	ENSPNYG00000019104	wdr5	100	94.910	Pundamilia_nyererei
ENSG00000196363	WDR5	100	95.808	ENSPNAG00000024152	wdr5	100	95.808	Pygocentrus_nattereri
ENSG00000196363	WDR5	100	91.018	ENSPNAG00000025678	-	100	91.018	Pygocentrus_nattereri
ENSG00000196363	WDR5	99	80.480	ENSRNOG00000002253	Wdr5b	99	80.480	Rattus_norvegicus
ENSG00000196363	WDR5	100	100.000	ENSRNOG00000008212	Wdr5	100	100.000	Rattus_norvegicus
ENSG00000196363	WDR5	100	100.000	ENSRBIG00000030357	WDR5	100	100.000	Rhinopithecus_bieti
ENSG00000196363	WDR5	99	84.985	ENSRBIG00000018771	WDR5B	99	84.985	Rhinopithecus_bieti
ENSG00000196363	WDR5	100	100.000	ENSRROG00000043200	WDR5	100	100.000	Rhinopithecus_roxellana
ENSG00000196363	WDR5	99	84.985	ENSRROG00000013553	WDR5B	99	84.985	Rhinopithecus_roxellana
ENSG00000196363	WDR5	100	100.000	ENSSBOG00000025822	WDR5	100	99.701	Saimiri_boliviensis_boliviensis
ENSG00000196363	WDR5	99	84.384	ENSSBOG00000009156	WDR5B	99	84.384	Saimiri_boliviensis_boliviensis
ENSG00000196363	WDR5	100	97.305	ENSSHAG00000013955	-	100	97.305	Sarcophilus_harrisii
ENSG00000196363	WDR5	99	91.291	ENSSHAG00000012454	-	99	91.291	Sarcophilus_harrisii
ENSG00000196363	WDR5	100	95.210	ENSSFOG00015011138	wdr5	100	95.210	Scleropages_formosus
ENSG00000196363	WDR5	100	96.108	ENSSFOG00015014856	-	100	96.108	Scleropages_formosus
ENSG00000196363	WDR5	100	93.413	ENSSMAG00000015719	wdr5	100	94.910	Scophthalmus_maximus
ENSG00000196363	WDR5	92	95.455	ENSSDUG00000019036	-	92	95.455	Seriola_dumerili
ENSG00000196363	WDR5	100	94.611	ENSSDUG00000020022	wdr5	100	94.611	Seriola_dumerili
ENSG00000196363	WDR5	100	92.515	ENSSLDG00000005696	-	100	93.114	Seriola_lalandi_dorsalis
ENSG00000196363	WDR5	100	94.611	ENSSLDG00000021297	wdr5	100	94.611	Seriola_lalandi_dorsalis
ENSG00000196363	WDR5	100	94.910	ENSSPAG00000008784	wdr5	100	94.910	Stegastes_partitus
ENSG00000196363	WDR5	100	99.102	ENSSSCG00000024912	WDR5	100	99.102	Sus_scrofa
ENSG00000196363	WDR5	100	97.006	ENSTGUG00000005765	WDR5B	100	97.006	Taeniopygia_guttata
ENSG00000196363	WDR5	100	94.311	ENSTRUG00000005982	wdr5	100	94.311	Takifugu_rubripes
ENSG00000196363	WDR5	99	91.892	ENSTNIG00000003824	wdr5	100	91.892	Tetraodon_nigroviridis
ENSG00000196363	WDR5	99	84.384	ENSTBEG00000003659	WDR5B	99	84.384	Tupaia_belangeri
ENSG00000196363	WDR5	100	98.958	ENSTTRG00000005344	WDR5	100	94.012	Tursiops_truncatus
ENSG00000196363	WDR5	100	100.000	ENSUAMG00000008521	WDR5	100	99.701	Ursus_americanus
ENSG00000196363	WDR5	99	83.483	ENSUAMG00000019107	WDR5B	99	83.483	Ursus_americanus
ENSG00000196363	WDR5	99	83.483	ENSUMAG00000025222	WDR5B	99	83.483	Ursus_maritimus
ENSG00000196363	WDR5	100	100.000	ENSUMAG00000023623	WDR5	71	100.000	Ursus_maritimus
ENSG00000196363	WDR5	99	84.685	ENSVPAG00000002152	WDR5B	99	84.685	Vicugna_pacos
ENSG00000196363	WDR5	100	100.000	ENSVVUG00000027514	WDR5	100	100.000	Vulpes_vulpes
ENSG00000196363	WDR5	100	97.006	ENSXETG00000019588	wdr5	100	97.006	Xenopus_tropicalis
ENSG00000196363	WDR5	100	94.611	ENSXMAG00000001746	wdr5	100	94.611	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000123	histone acetyltransferase complex	20018852.	IDA	Component
GO:0001501	skeletal system development	-	IEA	Process
GO:0005515	protein binding	12670868.15960975.16189514.16946699.17021013.17041588.17178841.17500065.17925232.17998332.18378692.18840606.19047629.19433796.19556245.20080758.20085832.20581860.20818375.21044950.21220120.23555304.23870121.23995757.24788516.25416956.27705803.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	17500065.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	18838386.	IDA	Component
GO:0031175	neuron projection development	-	IEA	Process
GO:0035064	methylated histone binding	16600877.	IDA	Function
GO:0035097	histone methyltransferase complex	17355966.17500065.19556245.	IDA	Component
GO:0035948	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter	-	IEA	Process
GO:0042393	histone binding	21873635.	IBA	Function
GO:0042800	histone methyltransferase activity (H3-K4 specific)	17355966.	IDA	Function
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0043966	histone H3 acetylation	18838386.	IDA	Process
GO:0043981	histone H4-K5 acetylation	20018852.	IDA	Process
GO:0043982	histone H4-K8 acetylation	20018852.	IDA	Process
GO:0043984	histone H4-K16 acetylation	20018852.	IDA	Process
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	20018852.	IDA	Function
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	20018852.	IDA	Function
GO:0044666	MLL3/4 complex	17500065.	IDA	Component
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	20018852.	IDA	Function
GO:0048188	Set1C/COMPASS complex	21873635.	IBA	Component
GO:0048188	Set1C/COMPASS complex	17998332.18838538.	IDA	Component
GO:0051568	histone H3-K4 methylation	21873635.	IBA	Process
GO:0051568	histone H3-K4 methylation	17355966.19556245.	IDA	Process
GO:0071339	MLL1 complex	15960975.	IDA	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.