EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28378571	Protein tyrosine phosphatase 1B expression contributes to the development of breast cancer.	J Zhejiang Univ Sci B	2017 Apr	Liao SC	doi: 10.1631/jzus.B1600184.
21849469	Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance.	Mol Cancer Res	2011 Oct	Balavenkatraman KK	doi: 10.1158/1541-7786.MCR-11-0198
23814025	PTP1B contributes to calreticulin-induced metastatic phenotypes in esophageal squamous cell carcinoma.	Mol Cancer Res	2013 Sep	Wang XM	doi: 10.1158/1541-7786.MCR-12-0704
24706663	PTPN1 is recurrently mutated in lymphoid cancers.	Cancer Discov	2014 Apr	-	doi: 10.1158/2159-8290.CD-RW2014-048
27855221	Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors.	PLoS One	2016 Nov 17	Mei W	doi: 10.1371/journal.pone.0166538
20388125	Suppression of PTP1B in gastric cancer cells in vitro induces a change in the genome-wide expression profile and inhibits gastric cancer cell growth.	Cell Biol Int	2010 Jul	Wang J	doi: 10.1042/CBI20090447.
17974954	PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation.	Cancer Res	2007 Nov 1	Zhu S	-
25590580	Frequent amplification of PTP1B is associated with poor survival of gastric cancer patients.	Cell Cycle	2015	Wang N	doi: 10.1080/15384101.2014.998047.
22282656	PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer.	Cancer Res	2012 Mar 15	Lessard L	doi: 10.1158/0008-5472.CAN-11-2602
19782770	The two faces of PTP1B in cancer.	Biochim Biophys Acta	2010 Mar	Lessard L	doi: 10.1016/j.bbapap.2009.09.018
24715221	Hypoxia-induced miR-210 in epithelial ovarian cancer enhances cancer cell viability via promoting proliferation and inhibiting apoptosis.	Int J Oncol	2014 Jun	Li L	doi: 10.3892/ijo.2014.2368
23814047	Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.	J Biol Chem	2013 Aug 23	Fan G	doi: 10.1074/jbc.M113.482737
20000419	Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.	J Med Chem	2010 Mar 25	Combs AP	doi: 10.1021/jm901090b.
25617799	PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.	Cancer Lett	2015 Apr 10	Liu H	doi: 10.1016/j.canlet.2015.01.020
20952588	PTP1B suppresses prolactin activation of Stat5 in breast cancer cells.	Am J Pathol	2010 Dec	Johnson KJ	doi: 10.2353/ajpath.2010.090399
16652382	Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer.	Prostate	2006 Aug 1	Wu C	-
23358729	Integral role of PTP1B in adiponectin-mediated inhibition of oncogenic actions of leptin in breast carcinogenesis.	Neoplasia	2013 Jan	Taliaferro-Smith L	-
23990346	Overexpression of PTP1B in human colorectal cancer and its association with tumor progression and prognosis.	J Mol Histol	2014 Apr	Chen Q	doi: 10.1007/s10735-013-9536-1
18332219	Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.	J Cell Biol	2008 Mar 10	Cortesio CL	doi: 10.1083/jcb.200708048.
21442314	PTP1B expression contributes to gastric cancer progression.	Med Oncol	2012 Jun	Wang J	doi: 10.1007/s12032-011-9911-2
24465712	pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1).	PLoS One	2014 Jan 22	Radhakrishnan VM	doi: 10.1371/journal.pone.0085796
27323329	PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.	Nat Cell Biol	2016 Jul	Banh RS	doi: 10.1038/ncb3376
26942883	Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome.	Oncotarget	2016 Apr 19	Hoekstra E	doi: 10.18632/oncotarget.7829.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr20	50579258	Missense_Mutation	rs763558512	D265N	0.41
BLCA	chr20	50579890	Missense_Mutation	novel	G351E	0.36
BLCA	chr20	50574528	Silent	novel	A122A	0.07
BLCA	chr20	50578444	Missense_Mutation	novel	H173Y	0.13
BLCA	chr20	50579710	Nonsense_Mutation	novel	W291*	0.4
BLCA	chr20	50564971	Missense_Mutation	novel	D53H	0.35
BRCA	chr20	50581368	Missense_Mutation	novel	D398Y	0.53
BRCA	chr20	50565069	Missense_Mutation	novel	Q85H	0.06
BRCA	chr20	50579290	Silent	rs371865249	I275I	0.14
CESC	chr20	50582834	3'UTR	novel		0.29
CESC	chr20	50574628	Nonsense_Mutation	NA	R156*	0.33
CESC	chr20	50584471	3'UTR	novel		0.29
CESC	chr20	50582837	3'UTR	novel		0.29
CESC	chr20	50574428	Intron	NA		0.15
COAD	chr20	50579865	Missense_Mutation	novel	D343N	0.18
COAD	chr20	50581301	Frame_Shift_Del	NA	*G377Efs27**	0.32
COAD	chr20	50579242	Silent	NA	G259G	0.18
COAD	chr20	50561435	Missense_Mutation	NA	Y46H	0.35
COAD	chr20	50581301	Frame_Shift_Del	NA	*G377Efs27**	0.23
COAD	chr20	50579310	Missense_Mutation	novel	M282T	0.07
COAD	chr20	50578558	Missense_Mutation	novel	V211I	0.15
COAD	chr20	50581426	Missense_Mutation	NA	T417M	0.2
COAD	chr20	50561441	Missense_Mutation	NA	D48Y	0.31
COAD	chr20	50579809	Missense_Mutation	novel	C324F	0.16
COAD	chr20	50582836	3'UTR	novel		0.33
COAD	chr20	50578576	Missense_Mutation	NA	A217T	0.24
ESCA	chr20	50579235	Missense_Mutation	novel	R257Q	0.52
ESCA	chr20	50510505	5'UTR	rs780413071		0.13
ESCA	chr20	50579268	Missense_Mutation	novel	R268L	0.24
ESCA	chr20	50583797	3'UTR	novel		0.31
ESCA	chr20	50581301	Frame_Shift_Del	NA	*G377Efs27**	0.26
ESCA	chr20	50581443	Missense_Mutation	rs367996563	A423T	0.29
GBM	chr20	50578441	Missense_Mutation	novel	L172V	0.09
GBM	chr20	50581419	Missense_Mutation	rs760420089	V415M	0.13
GBM	chr20	50579883	Missense_Mutation	novel	E349K	0.11
GBM	chr20	50578432	Silent	novel	R169R	0.19
GBM	chr20	50568388	Missense_Mutation	novel	L88F	0.07
GBM	chr20	50581402	Missense_Mutation	novel	F409Y	0.09
HNSC	chr20	50579819	Missense_Mutation	novel	F327L	0.21
HNSC	chr20	50581280	Silent	novel	T368T	0.22
HNSC	chr20	50578612	Missense_Mutation	novel	D229N	0.15
KIRC	chr20	50579889	Nonsense_Mutation	NA	G351*	0.31
KIRP	chr20	50578618	Missense_Mutation	NA	C231G	0.3
LGG	chr20	50581299	Missense_Mutation	novel	V375L	0.33
LUAD	chr20	50578586	Missense_Mutation	NA	G220D	0.32
LUAD	chr20	50579922	Missense_Mutation	rs759986577	E362K	0.36
LUSC	chr20	50561393	Missense_Mutation	NA	C32G	0.11
LUSC	chr20	50574550	Missense_Mutation	novel	E130K	0.21
OV	chr20	50581278	Missense_Mutation	novel	T368S	0.08
OV	chr20	50574565	Missense_Mutation	novel	F135V	0.07
OV	chr20	50579266	Silent	novel	L267L	0.16
PAAD	chr20	50579194	Silent	novel	S243S	0.12
PRAD	chr20	50579195	Missense_Mutation	rs371730106	V244I	0.21
PRAD	chr20	50574588	Silent	novel	L142L	0.36
READ	chr20	50574629	Missense_Mutation	NA	R156Q	0.18
READ	chr20	50574561	Missense_Mutation	NA	M133I	0.45
SARC	chr20	50584512	3'UTR	novel		0.23
SKCM	chr20	50581323	Nonsense_Mutation	NA	Q383*	0.33
SKCM	chr20	50579234	Missense_Mutation	NA	R257W	0.38
SKCM	chr20	50578602	Silent	NA	F225F	0.4
SKCM	chr20	50581333	Missense_Mutation	NA	S386F	0.35
SKCM	chr20	50579305	Silent	rs200862197	F280F	0.24
SKCM	chr20	50579239	Missense_Mutation	NA	M258I	0.21
SKCM	chr20	50578556	Missense_Mutation	novel	P210L	0.29
SKCM	chr20	50578417	Splice_Region	novel		0.43
STAD	chr20	50579200	Silent	novel	D245D	0.09
STAD	chr20	50568400	Silent	rs143550876	C92C	0.16
STAD	chr20	50579756	Frame_Shift_Del	NA	*P308Hfs27**	0.22
UCEC	chr20	50582843	3'UTR	novel		0.31
UCEC	chr20	50581275	Missense_Mutation	NA	D367Y	0.32
UCEC	chr20	50568401	Missense_Mutation	rs770497491	G93S	0.09
UCEC	chr20	50578477	Missense_Mutation	novel	V184I	0.29
UCEC	chr20	50583885	3'UTR	rs532835676		0.48
UCEC	chr20	50579233	Missense_Mutation	novel	F256L	0.06
UCEC	chr20	50581313	Silent	novel	L379L	0.38
UCEC	chr20	50568398	Missense_Mutation	rs189361363	C92R	0.06
UCEC	chr20	50581269	Missense_Mutation	novel	S365G	0.21
UCEC	chr20	50579917	Missense_Mutation	novel	G360D	0.25
UCEC	chr20	50581314	Nonsense_Mutation	rs763052949	R380*	0.47
UCEC	chr20	50584231	3'UTR	novel		0.11
UCEC	chr20	50579738	Silent	novel	E300E	0.43
UCEC	chr20	50561451	Missense_Mutation	novel	P51L	0.32
UCEC	chr20	50578585	Missense_Mutation	novel	G220S	0.52
UCEC	chr20	50579750	Missense_Mutation	novel	E304D	0.18
UCEC	chr20	50581443	Missense_Mutation	rs367996563	A423T	0.46
UCEC	chr20	50574525	Silent	rs371360165	C121C	0.36
UCEC	chr20	50582836	3'UTR	novel		0.57
UCEC	chr20	50578557	Silent	rs745951097	P210P	0.44
UCEC	chr20	50578583	Missense_Mutation	NA	I219T	0.25
UCEC	chr20	50584034	3'UTR	novel		0.33
UCEC	chr20	50579323	Silent	rs781401351	S286S	0.19
UCEC	chr20	50574525	Silent	rs371360165	C121C	0.33
UCEC	chr20	50584211	3'UTR	novel		0.36
UCEC	chr20	50581351	Missense_Mutation	NA	P392L	0.39
UCEC	chr20	50583860	3'UTR	novel		0.71
UCEC	chr20	50568393	Nonsense_Mutation	novel	*N90_T91insYQWLEETLPI**	0.01
UCEC	chr20	50581314	Nonsense_Mutation	rs763052949	R380*	0.36
UCEC	chr20	50574562	Missense_Mutation	novel	I134V	0.24
UCEC	chr20	50583853	3'UTR	novel		0.43
UCEC	chr20	50581314	Nonsense_Mutation	rs763052949	R380*	0.27
UCEC	chr20	50561427	Missense_Mutation	novel	R43Q	0.39
UCEC	chr20	50583906	3'UTR	novel		0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0262	0.14746
LUAD	DEL	0.0988	0.18308
PRAD	AMP	0.0549	0.07085

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0045	Kaplan-Meier Survival Analysis
SKCM	0.017	Kaplan-Meier Survival Analysis
LUSC	0.025	Kaplan-Meier Survival Analysis
ESCA	0.046	Kaplan-Meier Survival Analysis
CESC	0.047	Kaplan-Meier Survival Analysis
LAML	0.0001	Kaplan-Meier Survival Analysis
UCEC	0.04	Kaplan-Meier Survival Analysis
LIHC	0.0048	Kaplan-Meier Survival Analysis
LGG	0.0007	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis
OV	0.0078	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000196396 (Gene tree)
Gene ID: 5770
Gene Symbol: PTPN1
Alias: PTP1B
Full Name: protein tyrosine phosphatase non-receptor type 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 74,921 bases
Position: chr20:50,510,321-50,585,241
Accession: 9642
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000541713	PTPN1-202	3469	-	ENSP00000437732	362 (aa)	-	B4DSN5
ENST00000371621	PTPN1-201	4008	-	ENSP00000360683	435 (aa)	-	P18031

Gene Model

Click here to download ENSG00000196396's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04520	Adherens junction	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04931	Insulin resistance	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000196396	Platelet Function Tests	7.7715610E-015	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000196396	rs75146649	20	50575775	?	Heel bone mineral density	30048462	[0.012-0.026] unit increase	0.0193437	EFO_0009270
ENSG00000196396	rs754118	20	50575367	?	Age at loss of ambulation in Duchenne muscular dystrophy	30014611			Orphanet_98896\|EFO_0008336
ENSG00000196396	rs754118	20	50575367	?	Age at loss of ambulation in Duchenne muscular dystrophy	30014611			Orphanet_98896\|EFO_0008336
ENSG00000196396	rs6126042	20	50545649	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196396's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004725	protein tyrosine phosphatase activity	18074158.21707536.22169477.	IDA	Function
GO:0004725	protein tyrosine phosphatase activity	-	TAS	Function
GO:0005158	insulin receptor binding	-	IEA	Function
GO:0005515	protein binding	8702689.8940134.8999839.9050838.9355745.9407132.9418872.9566916.9600099.10660596.10889023.11007774.11106648.11163213.11506178.11579209.11694501.11970898.12023880.12176037.12237455.12614164.12634852.12857726.12907755.14527337.14722096.15588987.15821101.15866871.15894168.15976035.16115959.16271887.16388599.16537444.16582879.16644720.16926280.17092689.17128263.17159996.17197020.17416557.17481567.17974954.18387954.18515860.18579758.19029027.19167335.19712109.20627780.21806020.21972092.22789536.24658140.24976139.25796184.	IPI	Function
GO:0005769	early endosome	21135139.	IDA	Component
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	21135139.	IDA	Component
GO:0006470	protein dephosphorylation	22045810.	IMP	Process
GO:0007257	activation of JUN kinase activity	-	IEA	Process
GO:0008270	zinc ion binding	18074158.	IDA	Function
GO:0008286	insulin receptor signaling pathway	-	IEA	Process
GO:0009966	regulation of signal transduction	21135139.	IMP	Process
GO:0009968	negative regulation of signal transduction	-	TAS	Process
GO:0019899	enzyme binding	22169477.	IPI	Function
GO:0019901	protein kinase binding	22169477.	IPI	Function
GO:0030100	regulation of endocytosis	21135139.	IDA	Process
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	-	ISS	Process
GO:0030968	endoplasmic reticulum unfolded protein response	22169477.	IDA	Process
GO:0030971	receptor tyrosine kinase binding	18819921.	IPI	Function
GO:0031532	actin cytoskeleton reorganization	21135139.	IMP	Process
GO:0032991	protein-containing complex	28246125.	IDA	Component
GO:0033157	regulation of intracellular protein transport	22045810.	IMP	Process
GO:0034620	cellular response to unfolded protein	22013210.	TAS	Process
GO:0035335	peptidyl-tyrosine dephosphorylation	21135139.	IDA	Process
GO:0035335	peptidyl-tyrosine dephosphorylation	14966296.	IMP	Process
GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	14966296.	IMP	Process
GO:0036498	IRE1-mediated unfolded protein response	-	IEA	Process
GO:0043407	negative regulation of MAP kinase activity	22045810.	IMP	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046627	negative regulation of insulin receptor signaling pathway	11742412.	NAS	Process
GO:0046875	ephrin receptor binding	21135139.	IPI	Function
GO:0051721	protein phosphatase 2A binding	-	IEA	Function
GO:0060338	regulation of type I interferon-mediated signaling pathway	-	TAS	Process
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	-	TAS	Process
GO:0061098	positive regulation of protein tyrosine kinase activity	21216966.	IDA	Process
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	ISS	Process
GO:0097443	sorting endosome	-	ISS	Component
GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	1739967.	IDA	Component
GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway	18819921.	IMP	Process
GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	-	IEA	Process
GO:1903896	positive regulation of IRE1-mediated unfolded protein response	22013210.	TAS	Process
GO:1903898	negative regulation of PERK-mediated unfolded protein response	21216966.	IDA	Process
GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	-	ISS	Process
GO:2000646	positive regulation of receptor catabolic process	22045810.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.