EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28378571Protein tyrosine phosphatase 1B expression contributes to the development of breast cancer.J Zhejiang Univ Sci B2017 AprLiao SCdoi: 10.1631/jzus.B1600184.
21849469Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance.Mol Cancer Res2011 OctBalavenkatraman KKdoi: 10.1158/1541-7786.MCR-11-0198
23814025PTP1B contributes to calreticulin-induced metastatic phenotypes in esophageal squamous cell carcinoma.Mol Cancer Res2013 SepWang XMdoi: 10.1158/1541-7786.MCR-12-0704
24706663PTPN1 is recurrently mutated in lymphoid cancers.Cancer Discov2014 Apr-doi: 10.1158/2159-8290.CD-RW2014-048
27855221Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors.PLoS One2016 Nov 17Mei Wdoi: 10.1371/journal.pone.0166538
20388125Suppression of PTP1B in gastric cancer cells in vitro induces a change in the genome-wide expression profile and inhibits gastric cancer cell growth.Cell Biol Int2010 JulWang Jdoi: 10.1042/CBI20090447.
17974954PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation.Cancer Res2007 Nov 1Zhu S-
25590580Frequent amplification of PTP1B is associated with poor survival of gastric cancer patients.Cell Cycle2015Wang Ndoi: 10.1080/15384101.2014.998047.
22282656PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer.Cancer Res2012 Mar 15Lessard Ldoi: 10.1158/0008-5472.CAN-11-2602
19782770The two faces of PTP1B in cancer.Biochim Biophys Acta2010 MarLessard Ldoi: 10.1016/j.bbapap.2009.09.018
24715221Hypoxia-induced miR-210 in epithelial ovarian cancer enhances cancer cell viability via promoting proliferation and inhibiting apoptosis.Int J Oncol2014 JunLi Ldoi: 10.3892/ijo.2014.2368
23814047Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.J Biol Chem2013 Aug 23Fan Gdoi: 10.1074/jbc.M113.482737
20000419Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.J Med Chem2010 Mar 25Combs APdoi: 10.1021/jm901090b.
25617799PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.Cancer Lett2015 Apr 10Liu Hdoi: 10.1016/j.canlet.2015.01.020
20952588PTP1B suppresses prolactin activation of Stat5 in breast cancer cells.Am J Pathol2010 DecJohnson KJdoi: 10.2353/ajpath.2010.090399
16652382Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer.Prostate2006 Aug 1Wu C-
23358729Integral role of PTP1B in adiponectin-mediated inhibition of oncogenic actions of leptin in breast carcinogenesis.Neoplasia2013 JanTaliaferro-Smith L-
23990346Overexpression of PTP1B in human colorectal cancer and its association with tumor progression and prognosis.J Mol Histol2014 AprChen Qdoi: 10.1007/s10735-013-9536-1
18332219Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.J Cell Biol2008 Mar 10Cortesio CLdoi: 10.1083/jcb.200708048.
21442314PTP1B expression contributes to gastric cancer progression.Med Oncol2012 JunWang Jdoi: 10.1007/s12032-011-9911-2
24465712pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1).PLoS One2014 Jan 22Radhakrishnan VMdoi: 10.1371/journal.pone.0085796
27323329PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.Nat Cell Biol2016 JulBanh RSdoi: 10.1038/ncb3376
26942883Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome.Oncotarget2016 Apr 19Hoekstra Edoi: 10.18632/oncotarget.7829.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2050579258Missense_Mutationrs763558512D265N0.41
BLCAchr2050579890Missense_MutationnovelG351E0.36
BLCAchr2050574528SilentnovelA122A0.07
BLCAchr2050578444Missense_MutationnovelH173Y0.13
BLCAchr2050579710Nonsense_MutationnovelW291*0.4
BLCAchr2050564971Missense_MutationnovelD53H0.35
BRCAchr2050581368Missense_MutationnovelD398Y0.53
BRCAchr2050565069Missense_MutationnovelQ85H0.06
BRCAchr2050579290Silentrs371865249I275I0.14
CESCchr20505828343'UTRnovel0.29
CESCchr2050574628Nonsense_MutationNAR156*0.33
CESCchr20505844713'UTRnovel0.29
CESCchr20505828373'UTRnovel0.29
CESCchr2050574428IntronNA0.15
COADchr2050579865Missense_MutationnovelD343N0.18
COADchr2050581301Frame_Shift_DelNAG377Efs*270.32
COADchr2050579242SilentNAG259G0.18
COADchr2050561435Missense_MutationNAY46H0.35
COADchr2050581301Frame_Shift_DelNAG377Efs*270.23
COADchr2050579310Missense_MutationnovelM282T0.07
COADchr2050578558Missense_MutationnovelV211I0.15
COADchr2050581426Missense_MutationNAT417M0.2
COADchr2050561441Missense_MutationNAD48Y0.31
COADchr2050579809Missense_MutationnovelC324F0.16
COADchr20505828363'UTRnovel0.33
COADchr2050578576Missense_MutationNAA217T0.24
ESCAchr2050579235Missense_MutationnovelR257Q0.52
ESCAchr20505105055'UTRrs7804130710.13
ESCAchr2050579268Missense_MutationnovelR268L0.24
ESCAchr20505837973'UTRnovel0.31
ESCAchr2050581301Frame_Shift_DelNAG377Efs*270.26
ESCAchr2050581443Missense_Mutationrs367996563A423T0.29
GBMchr2050578441Missense_MutationnovelL172V0.09
GBMchr2050581419Missense_Mutationrs760420089V415M0.13
GBMchr2050579883Missense_MutationnovelE349K0.11
GBMchr2050578432SilentnovelR169R0.19
GBMchr2050568388Missense_MutationnovelL88F0.07
GBMchr2050581402Missense_MutationnovelF409Y0.09
HNSCchr2050579819Missense_MutationnovelF327L0.21
HNSCchr2050581280SilentnovelT368T0.22
HNSCchr2050578612Missense_MutationnovelD229N0.15
KIRCchr2050579889Nonsense_MutationNAG351*0.31
KIRPchr2050578618Missense_MutationNAC231G0.3
LGGchr2050581299Missense_MutationnovelV375L0.33
LUADchr2050578586Missense_MutationNAG220D0.32
LUADchr2050579922Missense_Mutationrs759986577E362K0.36
LUSCchr2050561393Missense_MutationNAC32G0.11
LUSCchr2050574550Missense_MutationnovelE130K0.21
OVchr2050581278Missense_MutationnovelT368S0.08
OVchr2050574565Missense_MutationnovelF135V0.07
OVchr2050579266SilentnovelL267L0.16
PAADchr2050579194SilentnovelS243S0.12
PRADchr2050579195Missense_Mutationrs371730106V244I0.21
PRADchr2050574588SilentnovelL142L0.36
READchr2050574629Missense_MutationNAR156Q0.18
READchr2050574561Missense_MutationNAM133I0.45
SARCchr20505845123'UTRnovel0.23
SKCMchr2050581323Nonsense_MutationNAQ383*0.33
SKCMchr2050579234Missense_MutationNAR257W0.38
SKCMchr2050578602SilentNAF225F0.4
SKCMchr2050581333Missense_MutationNAS386F0.35
SKCMchr2050579305Silentrs200862197F280F0.24
SKCMchr2050579239Missense_MutationNAM258I0.21
SKCMchr2050578556Missense_MutationnovelP210L0.29
SKCMchr2050578417Splice_Regionnovel0.43
STADchr2050579200SilentnovelD245D0.09
STADchr2050568400Silentrs143550876C92C0.16
STADchr2050579756Frame_Shift_DelNAP308Hfs*270.22
UCECchr20505828433'UTRnovel0.31
UCECchr2050581275Missense_MutationNAD367Y0.32
UCECchr2050568401Missense_Mutationrs770497491G93S0.09
UCECchr2050578477Missense_MutationnovelV184I0.29
UCECchr20505838853'UTRrs5328356760.48
UCECchr2050579233Missense_MutationnovelF256L0.06
UCECchr2050581313SilentnovelL379L0.38
UCECchr2050568398Missense_Mutationrs189361363C92R0.06
UCECchr2050581269Missense_MutationnovelS365G0.21
UCECchr2050579917Missense_MutationnovelG360D0.25
UCECchr2050581314Nonsense_Mutationrs763052949R380*0.47
UCECchr20505842313'UTRnovel0.11
UCECchr2050579738SilentnovelE300E0.43
UCECchr2050561451Missense_MutationnovelP51L0.32
UCECchr2050578585Missense_MutationnovelG220S0.52
UCECchr2050579750Missense_MutationnovelE304D0.18
UCECchr2050581443Missense_Mutationrs367996563A423T0.46
UCECchr2050574525Silentrs371360165C121C0.36
UCECchr20505828363'UTRnovel0.57
UCECchr2050578557Silentrs745951097P210P0.44
UCECchr2050578583Missense_MutationNAI219T0.25
UCECchr20505840343'UTRnovel0.33
UCECchr2050579323Silentrs781401351S286S0.19
UCECchr2050574525Silentrs371360165C121C0.33
UCECchr20505842113'UTRnovel0.36
UCECchr2050581351Missense_MutationNAP392L0.39
UCECchr20505838603'UTRnovel0.71
UCECchr2050568393Nonsense_MutationnovelN90_T91insY*QWLEETLPI0.01
UCECchr2050581314Nonsense_Mutationrs763052949R380*0.36
UCECchr2050574562Missense_MutationnovelI134V0.24
UCECchr20505838533'UTRnovel0.43
UCECchr2050581314Nonsense_Mutationrs763052949R380*0.27
UCECchr2050561427Missense_MutationnovelR43Q0.39
UCECchr20505839063'UTRnovel0.36

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LAMLDEL0.02620.14746
LUADDEL0.09880.18308
PRADAMP0.05490.07085

Survival Analysis
CancerP-value Q-value
MESO0.0045

Kaplan-Meier Survival Analysis

SKCM0.017

Kaplan-Meier Survival Analysis

LUSC0.025

Kaplan-Meier Survival Analysis

ESCA0.046

Kaplan-Meier Survival Analysis

CESC0.047

Kaplan-Meier Survival Analysis

LAML0.0001

Kaplan-Meier Survival Analysis

UCEC0.04

Kaplan-Meier Survival Analysis

LIHC0.0048

Kaplan-Meier Survival Analysis

LGG0.0007

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

OV0.0078

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000196396 (Gene tree)
Gene ID
5770
Gene Symbol
PTPN1
Alias
PTP1B
Full Name
protein tyrosine phosphatase non-receptor type 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
74,921 bases
Position
chr20:50,510,321-50,585,241
Accession
9642
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000541713PTPN1-2023469-ENSP00000437732362 (aa)-B4DSN5
ENST00000371621PTPN1-2014008-ENSP00000360683435 (aa)-P18031
Gene Model
Click here to download ENSG00000196396's gene model file
Pathways
Pathway IDPathway NameSource
hsa04520Adherens junctionKEGG
hsa04910Insulin signaling pathwayKEGG
hsa04931Insulin resistanceKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000196396Platelet Function Tests7.7715610E-015-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000196396rs751466492050575775?Heel bone mineral density30048462[0.012-0.026] unit increase0.0193437EFO_0009270
ENSG00000196396rs7541182050575367?Age at loss of ambulation in Duchenne muscular dystrophy30014611Orphanet_98896|EFO_0008336
ENSG00000196396rs7541182050575367?Age at loss of ambulation in Duchenne muscular dystrophy30014611Orphanet_98896|EFO_0008336
ENSG00000196396rs61260422050545649?Eosinophil counts30595370EFO_0004842
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196396's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0004725protein tyrosine phosphatase activity18074158.21707536.22169477.IDAFunction
GO:0004725protein tyrosine phosphatase activity-TASFunction
GO:0005158insulin receptor binding-IEAFunction
GO:0005515protein binding8702689.8940134.8999839.9050838.9355745.9407132.9418872.9566916.9600099.10660596.10889023.11007774.11106648.11163213.11506178.11579209.11694501.11970898.12023880.12176037.12237455.12614164.12634852.12857726.12907755.14527337.14722096.15588987.15821101.15866871.15894168.15976035.16115959.16271887.16388599.16537444.16582879.16644720.16926280.17092689.17128263.17159996.17197020.17416557.17481567.17974954.18387954.18515860.18579758.19029027.19167335.19712109.20627780.21806020.21972092.22789536.24658140.24976139.25796184.IPIFunction
GO:0005769early endosome21135139.IDAComponent
GO:0005783endoplasmic reticulum-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane21135139.IDAComponent
GO:0006470protein dephosphorylation22045810.IMPProcess
GO:0007257activation of JUN kinase activity-IEAProcess
GO:0008270zinc ion binding18074158.IDAFunction
GO:0008286insulin receptor signaling pathway-IEAProcess
GO:0009966regulation of signal transduction21135139.IMPProcess
GO:0009968negative regulation of signal transduction-TASProcess
GO:0019899enzyme binding22169477.IPIFunction
GO:0019901protein kinase binding22169477.IPIFunction
GO:0030100regulation of endocytosis21135139.IDAProcess
GO:0030948negative regulation of vascular endothelial growth factor receptor signaling pathway-ISSProcess
GO:0030968endoplasmic reticulum unfolded protein response22169477.IDAProcess
GO:0030971receptor tyrosine kinase binding18819921.IPIFunction
GO:0031532actin cytoskeleton reorganization21135139.IMPProcess
GO:0032991protein-containing complex28246125.IDAComponent
GO:0033157regulation of intracellular protein transport22045810.IMPProcess
GO:0034620cellular response to unfolded protein22013210.TASProcess
GO:0035335peptidyl-tyrosine dephosphorylation21135139.IDAProcess
GO:0035335peptidyl-tyrosine dephosphorylation14966296.IMPProcess
GO:0035791platelet-derived growth factor receptor-beta signaling pathway14966296.IMPProcess
GO:0036498IRE1-mediated unfolded protein response-IEAProcess
GO:0043407negative regulation of MAP kinase activity22045810.IMPProcess
GO:0045296cadherin binding25468996.HDAFunction
GO:0046627negative regulation of insulin receptor signaling pathway11742412.NASProcess
GO:0046875ephrin receptor binding21135139.IPIFunction
GO:0051721protein phosphatase 2A binding-IEAFunction
GO:0060338regulation of type I interferon-mediated signaling pathway-TASProcess
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway-TASProcess
GO:0061098positive regulation of protein tyrosine kinase activity21216966.IDAProcess
GO:0070373negative regulation of ERK1 and ERK2 cascade-ISSProcess
GO:0097443sorting endosome-ISSComponent
GO:0098554cytoplasmic side of endoplasmic reticulum membrane1739967.IDAComponent
GO:1902202regulation of hepatocyte growth factor receptor signaling pathway18819921.IMPProcess
GO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-IEAProcess
GO:1903896positive regulation of IRE1-mediated unfolded protein response22013210.TASProcess
GO:1903898negative regulation of PERK-mediated unfolded protein response21216966.IDAProcess
GO:1990264peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity-ISSProcess
GO:2000646positive regulation of receptor catabolic process22045810.IMPProcess
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