EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19048115	Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations.	Neoplasia	2008 Dec	Sangha N	-
20082856	Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization.	Cancer Genet Cytogenet	2010 Jan 15	Lee J	doi: 10.1016/j.cancergencyto.2009.09.005.
23528211	NF1 gene silencing induces upregulation of vascular endothelial growth factor expression in both Schwann and non-Schwann cells.	Exp Dermatol	2013 Apr	Kawachi Y	doi: 10.1111/exd.12115.
22945628	Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.	J Clin Invest	2012 Oct	Dai C	doi: 10.1172/JCI62727
27798892	Neurofibromin Expression is Associated with Aggressive Disease and Poor Outcome in Colorectal Carcinoma.	Anticancer Res	2016 Oct	Elzagheid A	-
12152785	Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms.	J Neuropathol Exp Neurol	2002 Aug	Perry A	-
24795011	Paths of resistance to EGFR inhibitors: is NF enough?	Cancer Discov	2014 May	Maertens O	doi: 10.1158/2159-8290.CD-14-0286.
16908010	Reconstitution of the NF1 GAP-related domain in NF1-deficient human Schwann cells.	Biochem Biophys Res Commun	2006 Sep 29	Thomas SL	-
20358387	Analysis of NF1 somatic mutations in cutaneous neurofibromas from patients with high tumor burden.	Neurogenetics	2010 Oct	Thomas L	doi: 10.1007/s10048-010-0240-y
23437333	Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.	PLoS One	2013	Reuss DE	doi: 10.1371/journal.pone.0057152
23423222	RAS/MEK-independent gene expression reveals BMP2-related malignant phenotypes in the Nf1-deficient MPNST.	Mol Cancer Res	2013 Jun	Sun D	doi: 10.1158/1541-7786.MCR-12-0593
17096025	The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways.	Cell Death Differ	2007 May	Shapira S	-
22015770	Deletion of the tumor-suppressor gene NF1 occurs in 5% of myeloid malignancies and is accompanied by a mutation in the remaining allele in half of the cases.	Leukemia	2012 Apr	Haferlach C	doi: 10.1038/leu.2011.296
12387455	Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas.	J Neuropathol Exp Neurol	2002 Oct	Wimmer K	-
12199909	Functional expression of NF1 tumor suppressor protein: association with keratin intermediate filaments during the early development of human epidermis.	BMC Dermatol	2002 Aug 29	Malminen M	-
26214590	Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.	Nat Genet	2015 Sep	Krauthammer M	doi: 10.1038/ng.3361
15988004	Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein.	Mol Cell Biol	2005 Jul	Yang G	-
21551249	Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation.	Cancer Res	2011 Jul 1	Mayes DA	doi: 10.1158/0008-5472.CAN-10-4558
24708790	Suprarenal solitary fibrous tumor associated with a NF1 gene mutation mimicking a kidney neoplasm: implications for surgical management.	World J Surg Oncol	2014 Apr 7	Conzo G	doi: 10.1186/1477-7819-12-87.
22294457	Internal tumor burden in neurofibromatosis Type I patients with large NF1 deletions.	Genes Chromosomes Cancer	2012 May	Kluwe L	doi: 10.1002/gcc.21931
17216419	Nf1 expression is dependent on strain background: implications for tumor suppressor haploinsufficiency studies.	Neurogenetics	2007 Apr	Hawes JJ	-
23288408	A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.	Cancer Discov	2013 Mar	Whittaker SR	doi: 10.1158/2159-8290.CD-12-0470
27477693	Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors.	Oncogene	2017 Feb 23	Ki DH	doi: 10.1038/onc.2016.269
28646022	NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response.	Cancer Res	2017 Aug 15	Dodd RD	doi: 10.1158/0008-5472.CAN-16-2643
29392777	p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression.	Glia	2018 May	Gonzalez PP	doi: 10.1002/glia.23297
30479396	NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation.	Nat Commun	2018 Nov 27	Brosseau JP	doi: 10.1038/s41467-018-07452-y.
22412049	The neurofibromin 1 type I isoform predominance characterises female population affected by sporadic breast cancer: preliminary data.	J Clin Pathol	2012 May	Marrero D	doi: 10.1136/jclinpath-2011-200569
25267367	Neurofibromatosis with male breast cancer--risk factor or co-incidence? Report of two rare cases.	Breast Dis	2015	Tandon M	doi: 10.3233/BD-140387.
21280148	Mosaic type-1 NF1 microdeletions as a cause of both generalized and segmental neurofibromatosis type-1 (NF1).	Hum Mutat	2011 Feb	Messiaen L	doi: 10.1002/humu.21418.
23165953	Increased risk of breast cancer in women with NF1.	Am J Med Genet A	2012 Dec	Madanikia SA	doi: 10.1002/ajmg.a.35550
20124472	The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo.	Cancer Res	2010 Feb 15	Banerjee S	doi: 10.1158/0008-5472.CAN-09-2178
23624750	Increased Reach of Genetic Cancer Risk Assessment as a Tool for Precision Management of Hereditary Breast Cancer.	JAMA Oncol	2016 Jun 1	Blazer KR	doi: 10.1001/jamaoncol.2015.5975.
24932921	Neurofibromin deficiency-associated transcriptional dysregulation suggests a novel therapy for tibial pseudoarthrosis in NF1.	J Bone Miner Res	2014 Dec	Paria N	doi: 10.1002/jbmr.2298.
23135915	Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.	Cancer Res	2013 Jan 15	Ray BK	doi: 10.1158/0008-5472.CAN-12-2601
22965642	Breast cancer and other neoplasms in women with neurofibromatosis type 1: a retrospective review of cases in the Detroit metropolitan area.	Am J Med Genet A	2012 Dec	Wang X	doi: 10.1002/ajmg.a.35560
28067895	The NF1 gene in tumor syndromes and melanoma.	Lab Invest	2017 Feb	Kiuru M	doi: 10.1038/labinvest.2016.142
28108518	A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer.	Cancer Res	2017 Mar 15	Su??rez-Cabrera C	doi: 10.1158/0008-5472.CAN-16-1586
26861459	Clinical and Molecular Characteristics of NF1-Mutant Lung Cancer.	Clin Cancer Res	2016 Jul 1	Redig AJ	doi: 10.1158/1078-0432.CCR-15-2377
27494896	MicroRNA 10b promotes abnormal expression of the proto-oncogene c-Jun in metastatic breast cancer cells.	Oncotarget	2016 Sep 13	Knirsh R	doi: 10.18632/oncotarget.11000.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr17	31233208	Nonsense_Mutation	novel	Q1235*	0.66
ACC	chr17	31334931	Frame_Shift_Del	novel	*R1970Efs9**	0.65
ACC	chr17	31337403	Nonsense_Mutation	novel	E2155*	0.67
ACC	chr17	31201041	Missense_Mutation	novel	L356Q	0.71
ACC	chr17	31335029	Nonsense_Mutation	novel	Q2002*	0.67
ACC	chr17	31327810	Frame_Shift_Ins	novel	*N1861Kfs6**	0.8
ACC	chr17	31206308	Silent	novel	F443F	0.56
ACC	chr17	31227290	Splice_Site	novel	X775_splice	0.87
BLCA	chr17	31229665	Intron	novel		0.27
BLCA	chr17	31265265	Frame_Shift_Del	novel	*T1589Rfs2**	0.15
BLCA	chr17	31249062	Missense_Mutation	NA	I1351M	0.08
BLCA	chr17	31227604	Missense_Mutation	novel	Q803E	0.05
BLCA	chr17	31337506	Missense_Mutation	novel	P2189R	0.07
BLCA	chr17	31227232	Nonsense_Mutation	NA	Q756*	0.27
BLCA	chr17	31225094	Splice_Site	novel	X616_splice	0.4
BLCA	chr17	31229838	Frame_Shift_Del	novel	*L952Yfs19**	0.43
BLCA	chr17	31352390	Nonsense_Mutation	novel	Q2531*	0.2
BLCA	chr17	31357060	Silent	rs752218441	P2613P	0.25
BLCA	chr17	31226432	Splice_Region	novel		0.22
BLCA	chr17	31260406	Missense_Mutation	novel	D1490Y	0.2
BLCA	chr17	31356556	Missense_Mutation	novel	R2571T	0.08
BLCA	chr17	31156114	Silent	novel	N64N	0.11
BLCA	chr17	31350210	Missense_Mutation	rs533110479	R2450Q	0.16
BLCA	chr17	31226654	Missense_Mutation	novel	F741L	0.32
BLCA	chr17	31225246	Missense_Mutation	NA	S666C	0.15
BLCA	chr17	31352300	Nonsense_Mutation	NA	E2501*	0.13
BLCA	chr17	31181718	Nonsense_Mutation	NA	W221*	0.43
BLCA	chr17	31200444	Missense_Mutation	rs76015786	R304Q	0.46
BLCA	chr17	31214466	Nonsense_Mutation	NA	E470*	0.43
BLCA	chr17	31230327	Missense_Mutation	NA	E1020K	0.45
BLCA	chr17	31356991	Silent	novel	H2590H	0.25
BLCA	chr17	31232823	Silent	novel	V1146V	0.2
BLCA	chr17	31336843	Missense_Mutation	novel	R2119T	0.56
BLCA	chr17	31337517	Missense_Mutation	novel	E2193K	0.57
BLCA	chr17	31338024	Splice_Site	NA	X2235_splice	0.56
BLCA	chr17	31206343	Missense_Mutation	novel	G455E	0.24
BLCA	chr17	31229647	Intron	novel		0.25
BLCA	chr17	31163301	Missense_Mutation	novel	R135L	0.59
BLCA	chr17	31330351	Missense_Mutation	rs764782945	E1889K	0.34
BLCA	chr17	31163332	Silent	NA	L145L	0.15
BLCA	chr17	31232108	Nonsense_Mutation	novel	S1078*	0.52
BLCA	chr17	31343086	Silent	novel	L2380L	0.5
BLCA	chr17	31200502	Silent	rs786201462	A323A	0.1
BLCA	chr17	31206318	Missense_Mutation	NA	L447F	0.31
BLCA	chr17	31230886	Nonsense_Mutation	NA	S1053*	0.27
BLCA	chr17	31201118	Missense_Mutation	novel	S382P	0.41
BLCA	chr17	31219128	Intron	novel		0.43
BLCA	chr17	31374109	Missense_Mutation	NA	R2825T	0.16
BLCA	chr17	31349218	Missense_Mutation	novel	E2430Q	0.09
BLCA	chr17	31349220	Silent	novel	E2430E	0.09
BLCA	chr17	31227232	Nonsense_Mutation	NA	Q756*	0.91
BLCA	chr17	31336794	Missense_Mutation	novel	L2103F	0.42
BLCA	chr17	31235661	Silent	novel	L1253L	0.21
BLCA	chr17	31249030	Nonsense_Mutation	rs137854559	Q1341*	0.25
BLCA	chr17	31326170	Frame_Shift_Del	novel	*T1730Pfs4**	0.34
BLCA	chr17	31338055	Silent	novel	Q2245Q	0.44
BRCA	chr17	31336704	Missense_Mutation	novel	L2073V	0.23
BRCA	chr17	31235639	Frame_Shift_Del	NA	*F1247Ifs18**	0.28
BRCA	chr17	31235964	Missense_Mutation	NA	R1306Q	0.08
BRCA	chr17	31236023	Splice_Site	NA	X1325_splice	0.39
BRCA	chr17	31219101	Frame_Shift_Ins	novel	*A542Efs21**	0.06
BRCA	chr17	31201052	Missense_Mutation	novel	P360A	0.24
BRCA	chr17	31235773	Splice_Site	NA	X1290_splice	0.25
BRCA	chr17	31375013	3'UTR	novel		0.1
BRCA	chr17	31265318	Frame_Shift_Del	NA	*Y1607Ifs17**	0.63
BRCA	chr17	31340636	Missense_Mutation	NA	F2351L	0.3
BRCA	chr17	31156044	Frame_Shift_Del	NA	*E41Dfs3**	0.34
BRCA	chr17	31181490	Splice_Site	novel	X218_splice	0.11
BRCA	chr17	31229171	Silent	rs771308677	L852L	0.2
BRCA	chr17	31219047	Missense_Mutation	NA	E524Q	0.14
BRCA	chr17	31200572	Nonsense_Mutation	NA	Q347*	0.85
BRCA	chr17	31229490	Intron	novel		0.41
BRCA	chr17	31222011	Intron	novel		0.18
BRCA	chr17	31258338	Splice_Site	novel	X1392_splice	0.76
BRCA	chr17	31221868	Nonsense_Mutation	novel	Q554*	0.08
BRCA	chr17	31230872	Nonsense_Mutation	novel	W1048*	0.11
BRCA	chr17	31336841	Frame_Shift_Ins	novel	*R2119Qfs10**	0.08
BRCA	chr17	31358599	Frame_Shift_Del	novel	*Y2698Hfs39**	0.48
BRCA	chr17	31330366	Missense_Mutation	rs774893767	E1894Q	0.21
BRCA	chr17	31219080	Nonsense_Mutation	NA	Q535*	0.34
BRCA	chr17	31235608	Splice_Region	novel		0.19
BRCA	chr17	31343130	Splice_Site	novel	X2397_splice	0.23
BRCA	chr17	31374134	Silent	rs142636150	N2833N	0.19
BRCA	chr17	31259040	Missense_Mutation	NA	Q1447H	0.27
BRCA	chr17	31232838	Silent	novel	N1151N	0.06
BRCA	chr17	31358545	Missense_Mutation	NA	N2679S	0.14
BRCA	chr17	31214450	Splice_Site	NA	X465_splice	0.12
BRCA	chr17	31336722	Missense_Mutation	novel	A2079S	0.08
BRCA	chr17	31261855	Splice_Site	NA	X1575_splice	0.25
BRCA	chr17	31357023	Nonsense_Mutation	NA	S2601*	0.67
BRCA	chr17	31235650	Missense_Mutation	NA	R1250W	0.31
BRCA	chr17	31327607	Silent	rs761676110	L1793L	0.07
BRCA	chr17	31226580	Missense_Mutation	NA	E716V	0.23
BRCA	chr17	31358497	Frame_Shift_Ins	novel	K2664*	0.28
BRCA	chr17	31330373	Missense_Mutation	NA	S1896L	0.26
BRCA	chr17	31330501	Splice_Region	novel		0.83
BRCA	chr17	31249063	Missense_Mutation	NA	S1352G	0.25
BRCA	chr17	31219063	Missense_Mutation	novel	L529P	0.08
BRCA	chr17	31229754	Intron	novel		0.12
BRCA	chr17	31326184	Nonsense_Mutation	NA	E1734*	0.15
BRCA	chr17	31358589	Frame_Shift_Ins	NA	*P2696Tfs14**	0.36
BRCA	chr17	31356957	Splice_Region	novel		0.76
BRCA	chr17	31221921	Nonsense_Mutation	NA	W571*	0.13
BRCA	chr17	31163254	Frame_Shift_Ins	novel	*F120Pfs46**	0.11
BRCA	chr17	31357276	Frame_Shift_Del	novel	*V2627Nfs8**	0.32
BRCA	chr17	31327768	Silent	NA	R1846R	0.4
BRCA	chr17	31163271	Missense_Mutation	novel	R125P	0.48
BRCA	chr17	31200484	Frame_Shift_Del	NA	*E318Kfs11**	0.76
BRCA	chr17	31252700	Intron	novel		0.2
BRCA	chr17	31201070	Nonsense_Mutation	NA	R366*	0.1
BRCA	chr17	31252790	Intron	novel		0.36
BRCA	chr17	31377384	3'UTR	novel		0.1
CESC	chr17	31094982	5'UTR	novel		0.43
CESC	chr17	31338065	Missense_Mutation	novel	L2249V	0.33
CESC	chr17	31336814	Silent	NA	F2109F	0.16
CESC	chr17	31229467	Splice_Site	NA	X950_splice	0.14
CESC	chr17	31350209	Nonsense_Mutation	rs786202457	R2450*	0.11
CESC	chr17	31377545	3'UTR	novel		0.26
CESC	chr17	31232791	Missense_Mutation	NA	R1136W	0.52
CESC	chr17	31367275	Intron	novel		0.1
CESC	chr17	31227285	Silent	novel	N773N	0.42
CESC	chr17	31327783	Silent	novel	P1851P	0.11
CESC	chr17	31375013	3'UTR	novel		0.02
CESC	chr17	31182549	Nonsense_Mutation	NA	E258*	0.31
CESC	chr17	31200552	Missense_Mutation	rs771089333	S340C	0.42
CESC	chr17	31334918	Missense_Mutation	NA	D1965N	0.25
CESC	chr17	31357078	Frame_Shift_Ins	novel	*L2620Tfs14**	0.07
CESC	chr17	31375013	3'UTR	novel		0.1
CESC	chr17	31261833	Nonsense_Mutation	NA	S1567*	0.29
CESC	chr17	31226626	Silent	NA	L731L	0.34
CESC	chr17	31227570	Missense_Mutation	NA	I791M	0.25
CESC	chr17	31229188	Missense_Mutation	NA	S858Y	0.26
CESC	chr17	31229606	Intron	novel		0.26
CESC	chr17	31201423	Nonsense_Mutation	NA	Q400*	0.38
CESC	chr17	31229406	Missense_Mutation	rs764290369	P931A	0.38
CESC	chr17	31229911	Missense_Mutation	novel	T976N	0.36
CESC	chr17	31235729	Missense_Mutation	rs137854556	R1276Q	0.42
CESC	chr17	31337486	Nonsense_Mutation	novel	Y2182*	0.4
CESC	chr17	31340614	Missense_Mutation	novel	T2344I	0.34
CESC	chr17	31360668	Missense_Mutation	novel	S2781F	0.32
CESC	chr17	31374312	3'UTR	novel		0.4
CESC	chr17	31375258	3'UTR	novel		0.25
CESC	chr17	31230327	Missense_Mutation	NA	E1020K	0.33
CESC	chr17	31214537	Silent	rs139653388	L493L	0.32
CESC	chr17	31258365	Nonsense_Mutation	NA	Q1399*	0.23
CESC	chr17	31375013	3'UTR	novel		0.06
CESC	chr17	31374653	3'UTR	novel		0.58
CESC	chr17	31229870	In_Frame_Del	novel	E962_A966delinsD	0.04
CESC	chr17	31374676	3'UTR	novel		0.31
CESC	chr17	31325853	Silent	NA	L1623L	0.51
CESC	chr17	31252949	Silent	novel	H1374H	0.37
CHOL	chr17	31375013	3'UTR	novel		0.03
CHOL	chr17	31261795	Silent	novel	V1554V	0.07
CHOL	chr17	31337876	Nonsense_Mutation	NA	Q2234*	0.31
CHOL	chr17	31235963	Nonsense_Mutation	NA	R1306*	0.09
CHOL	chr17	31375013	3'UTR	novel		0.06
COAD	chr17	31367242	Intron	NA		0.27
COAD	chr17	31338140	Splice_Site	NA	X2273_splice	0.13
COAD	chr17	31349141	Missense_Mutation	rs771706364	A2404V	0.48
COAD	chr17	31334998	Silent	NA	S1991S	0.13
COAD	chr17	31260498	Missense_Mutation	NA	Q1520H	0.21
COAD	chr17	31356474	Missense_Mutation	novel	F2544V	0.3
COAD	chr17	31226460	Frame_Shift_Del	rs747195556	*P678Rfs10**	0.35
COAD	chr17	31219135	Intron	NA		0.25
COAD	chr17	31357058	Missense_Mutation	NA	P2613T	0.04
COAD	chr17	31229444	Frame_Shift_Ins	NA	D946*	0.2
COAD	chr17	31258461	Missense_Mutation	NA	P1431S	0.24
COAD	chr17	31232760	Silent	rs112589561	A1125A	0.14
COAD	chr17	31156033	Silent	NA	E37E	0.12
COAD	chr17	31219088	Silent	NA	H537H	0.24
COAD	chr17	31252775	Intron	NA		0.21
COAD	chr17	31350222	Missense_Mutation	NA	S2454N	0.19
COAD	chr17	31352415	Splice_Site	NA	X2539_splice	0.15
COAD	chr17	31374233	3'UTR	novel		0.29
COAD	chr17	31352332	Silent	rs760733171	V2511V	0.22
COAD	chr17	31225125	Frame_Shift_Ins	NA	*Y628Lfs6**	0.17
COAD	chr17	31226459	Frame_Shift_Ins	rs780157990	*I679Dfs21**	0.37
COAD	chr17	31260516	Splice_Site	NA	X1526_splice	0.39
COAD	chr17	31229677	Intron	NA		0.27
COAD	chr17	31235729	Missense_Mutation	rs137854556	R1276Q	0.24
COAD	chr17	31229466	Splice_Site	NA	X950_splice	0.17
COAD	chr17	31232761	Nonsense_Mutation	NA	Q1126*	0.17
COAD	chr17	31381885	3'Flank	rs755946375		0.07
COAD	chr17	31252978	Frame_Shift_Del	NA	*K1386Rfs20**	0.33
COAD	chr17	31229274	Missense_Mutation	NA	A887T	0.07
COAD	chr17	31325942	Missense_Mutation	rs763413441	R1653H	0.19
COAD	chr17	31374233	3'UTR	novel		0.09
COAD	chr17	31232840	Missense_Mutation	NA	L1152S	0.39
COAD	chr17	31219254	Intron	novel		0.38
COAD	chr17	31230329	Missense_Mutation	novel	E1020D	0.07
COAD	chr17	31327787	Missense_Mutation	NA	T1853A	0.15
COAD	chr17	31219102	Missense_Mutation	NA	A542D	0.14
COAD	chr17	31252778	Intron	novel		0.38
COAD	chr17	31343031	Missense_Mutation	NA	A2362V	0.27
COAD	chr17	31350209	Nonsense_Mutation	rs786202457	R2450*	0.33
COAD	chr17	31357308	Nonsense_Mutation	rs786201367	R2637*	0.34
COAD	chr17	31360591	Silent	NA	L2755L	0.4
COAD	chr17	31235964	Missense_Mutation	NA	R1306Q	0.2
COAD	chr17	31181736	Silent	rs745804540	Y227Y	0.24
COAD	chr17	31252963	Missense_Mutation	NA	K1379T	0.18
COAD	chr17	31374149	Silent	NA	I2838I	0.18
COAD	chr17	31359015	Missense_Mutation	NA	K2720N	0.13
COAD	chr17	31229232	Missense_Mutation	rs199474739	R873C	0.33
COAD	chr17	31349214	Frame_Shift_Ins	novel	*F2429Qfs7**	0.17
COAD	chr17	31249093	Nonsense_Mutation	rs137854560	R1362*	0.86
DLBC	chr17	31334908	Frame_Shift_Ins	novel	*H1962Pfs2**	0.23
DLBC	chr17	31201428	Missense_Mutation	novel	N401K	0.1
ESCA	chr17	31375013	3'UTR	novel		0.22
ESCA	chr17	31232812	Missense_Mutation	novel	H1143Y	0.3
ESCA	chr17	31375620	3'UTR	novel		0.1
ESCA	chr17	31375013	3'UTR	novel		0.04
ESCA	chr17	31227285	Silent	novel	N773N	0.57
ESCA	chr17	31200443	Nonsense_Mutation	rs786203950	R304*	0.35
ESCA	chr17	31326231	Missense_Mutation	novel	K1749N	0.22
ESCA	chr17	31343022	Missense_Mutation	novel	V2359A	0.82
ESCA	chr17	31229569	Intron	novel		0.27
ESCA	chr17	31375013	3'UTR	novel		0.25
ESCA	chr17	31219074	Missense_Mutation	novel	V533I	0.42
ESCA	chr17	31375013	3'UTR	novel		0.02
GBM	chr17	31229146	Missense_Mutation	rs137854566	L844P	0.34
GBM	chr17	31358479	Splice_Site	novel	X2657_splice	0.49
GBM	chr17	31232119	Missense_Mutation	novel	G1082C	0.14
GBM	chr17	31181462	Missense_Mutation	NA	Q209H	0.21
GBM	chr17	31181464	Nonsense_Mutation	NA	L210*	0.21
GBM	chr17	31325958	Frame_Shift_Del	NA	*K1661Gfs36**	0.2
GBM	chr17	31163271	Missense_Mutation	rs149003051	R125H	0.37
GBM	chr17	31340510	Frame_Shift_Del	NA	*P2310Lfs9**	0.71
GBM	chr17	31352373	Frame_Shift_Del	novel	*D2525Afs23**	0.14
GBM	chr17	31352375	Frame_Shift_Del	novel	*M2526Wfs22**	0.14
GBM	chr17	31357370	Splice_Site	novel	X2657_splice	0.27
GBM	chr17	31155995	Missense_Mutation	novel	T25P	0.09
GBM	chr17	31223502	In_Frame_Del	novel	T594_R601del	0.17
GBM	chr17	31169985	Nonsense_Mutation	rs397514641	R192*	0.15
GBM	chr17	31225146	Frame_Shift_Del	novel	*D633Ifs55**	0.13
GBM	chr17	31221889	Missense_Mutation	NA	W561R	0.11
GBM	chr17	31182532	Nonsense_Mutation	novel	L252*	0.29
GBM	chr17	31214458	Frame_Shift_Del	novel	*T467Nfs6**	0.18
GBM	chr17	31325958	Frame_Shift_Del	NA	*K1661Gfs36**	0.31
GBM	chr17	31350190	Frame_Shift_Ins	novel	*T2444Nfs4**	0.38
GBM	chr17	31336635	Frame_Shift_Ins	novel	*S2064Lfs7**	0.47
GBM	chr17	31169985	Nonsense_Mutation	rs397514641	R192*	0.22
GBM	chr17	31327659	Frame_Shift_Ins	novel	*T1811Hfs8**	0.34
GBM	chr17	31334880	Nonsense_Mutation	NA	W1952*	0.65
GBM	chr17	31265245	Missense_Mutation	novel	K1581Q	0.25
GBM	chr17	31325998	Missense_Mutation	NA	D1672N	0.28
GBM	chr17	31327498	Splice_Site	novel	X1757_splice	0.19
GBM	chr17	31343010	Missense_Mutation	novel	S2355N	0.17
GBM	chr17	31350252	Missense_Mutation	novel	T2464I	0.41
GBM	chr17	31357336	Missense_Mutation	novel	A2646V	0.19
GBM	chr17	31336331	Splice_Site	NA	X2003_splice	0.09
GBM	chr17	31258386	Missense_Mutation	novel	G1406R	0.13
GBM	chr17	31260383	Missense_Mutation	rs746994734	I1482T	0.24
GBM	chr17	31327775	Missense_Mutation	NA	D1849N	0.3
GBM	chr17	31352348	Nonsense_Mutation	NA	R2517*	0.82
GBM	chr17	31206286	Nonsense_Mutation	NA	S436*	0.09
GBM	chr17	31338140	Splice_Site	NA	X2273_splice	0.08
GBM	chr17	31249116	Frame_Shift_Del	novel	*Q1370Rfs8**	0.09
GBM	chr17	31229463	Nonsense_Mutation	NA	Q950*	0.26
GBM	chr17	31261733	Nonsense_Mutation	rs760703505	R1534*	0.31
GBM	chr17	31327673	Nonsense_Mutation	NA	Q1815*	0.58
GBM	chr17	31200444	Missense_Mutation	rs76015786	R304Q	0.26
GBM	chr17	31229541	Intron	novel		0.09
GBM	chr17	31233135	Silent	rs201378351	E1210E	0.34
GBM	chr17	31235963	Nonsense_Mutation	NA	R1306*	0.18
GBM	chr17	31230891	Nonsense_Mutation	NA	Q1055*	0.49
GBM	chr17	31230318	Nonsense_Mutation	NA	Q1017*	0.96
GBM	chr17	31229466	Splice_Site	NA	X950_splice	0.36
GBM	chr17	31356572	Frame_Shift_Del	novel	*Y2577Mfs47**	0.39
GBM	chr17	31334984	Nonsense_Mutation	NA	Q1987*	0.31
GBM	chr17	31340578	Nonsense_Mutation	NA	S2332*	0.32
GBM	chr17	31326024	Frame_Shift_Ins	novel	*N1681Kfs3**	0.9
GBM	chr17	31325958	Frame_Shift_Del	NA	*K1661Gfs36**	0.21
GBM	chr17	31169985	Nonsense_Mutation	rs397514641	R192*	0.41
GBM	chr17	31206360	Nonsense_Mutation	NA	R461*	0.09
GBM	chr17	31233115	Frame_Shift_Del	novel	*R1204Gfs11**	0.25
GBM	chr17	31334927	Nonsense_Mutation	rs137854552	R1968*	0.27
GBM	chr17	31181760	Nonsense_Mutation	rs769048538	Y235*	0.43
GBM	chr17	31226564	Missense_Mutation	novel	R711C	0.12
GBM	chr17	31232186	Missense_Mutation	NA	L1104R	0.42
GBM	chr17	31260486	Silent	NA	E1516E	0.07
GBM	chr17	31206360	Nonsense_Mutation	NA	R461*	0.38
GBM	chr17	31225114	Missense_Mutation	NA	C622F	0.4
GBM	chr17	31226621	Missense_Mutation	novel	N730H	0.05
GBM	chr17	31338790	Frame_Shift_Del	NA	*Q2302Hfs17**	0.33
GBM	chr17	31229145	Missense_Mutation	rs199474785	L844F	0.18
GBM	chr17	31340534	Nonsense_Mutation	novel	W2317*	0.34
HNSC	chr17	31200522	Missense_Mutation	novel	A330V	0.2
HNSC	chr17	31229255	Silent	rs786202443	V880V	0.25
HNSC	chr17	31338105	Missense_Mutation	novel	G2262E	0.35
HNSC	chr17	31221850	Missense_Mutation	novel	A548S	0.08
HNSC	chr17	31201484	Missense_Mutation	novel	N420I	0.61
HNSC	chr17	31232122	Missense_Mutation	novel	L1083F	0.15
HNSC	chr17	31259043	Missense_Mutation	novel	S1448R	0.22
HNSC	chr17	31357040	Missense_Mutation	novel	E2607K	0.34
HNSC	chr17	31163328	Missense_Mutation	novel	S144F	0.17
HNSC	chr17	31181712	Splice_Region	novel	A219A	0.21
HNSC	chr17	31374195	3'UTR	novel		0.42
HNSC	chr17	31336688	Silent	novel	P2067P	0.19
HNSC	chr17	31356505	Missense_Mutation	rs756138226	P2554L	0.16
HNSC	chr17	31336887	Missense_Mutation	NA	C2134R	0.49
HNSC	chr17	31201423	Nonsense_Mutation	NA	Q400*	0.43
HNSC	chr17	31221853	Silent	novel	L549L	0.46
KICH	chr17	31326028	Missense_Mutation	novel	C1682R	0.45
KIRC	chr17	31229182	Missense_Mutation	NA	S856N	0.29
KIRC	chr17	31337566	Missense_Mutation	NA	L2209S	0.33
KIRC	chr17	31357004	Missense_Mutation	NA	K2595E	0.26
KIRC	chr17	31229057	Silent	novel	K814K	0.23
KIRC	chr17	31360552	Nonsense_Mutation	novel	Y2742*	0.39
KIRC	chr17	31206285	In_Frame_Ins	novel	S436delinsCSFKFYP	0.08
KIRC	chr17	31360559	Nonsense_Mutation	NA	G2745*	0.26
KIRC	chr17	31261734	Frame_Shift_Del	novel	*R1534Hfs40**	0.38
KIRP	chr17	31156015	Missense_Mutation	novel	H31Q	0.42
KIRP	chr17	31360626	Missense_Mutation	novel	Q2767R	0.57
KIRP	chr17	31327724	Missense_Mutation	novel	E1832K	0.26
KIRP	chr17	31163370	Frame_Shift_Del	novel	*S158Lfs7**	0.54
KIRP	chr17	31200504	Missense_Mutation	rs778890596	C324S	0.35
LAML	chr17	31229140	Missense_Mutation	novel	G842D	0.16
LAML	chr17	31235729	Missense_Mutation	rs137854556	R1276Q	0.06
LAML	chr17	31226661	Missense_Mutation	novel	S743F	0.04
LAML	chr17	31360688	Missense_Mutation	novel	S2788P	0.03
LAML	chr17	31326010	Missense_Mutation	novel	A1676S	0.21
LAML	chr17	31235623	Nonsense_Mutation	rs137854562	R1241*	0.06
LGG	chr17	31200508	Frame_Shift_Ins	novel	*L327Tfs3**	0.21
LGG	chr17	31223475	Frame_Shift_Del	novel	L585*	0.25
LGG	chr17	31221883	Frame_Shift_Del	novel	*D559Ifs9**	0.34
LGG	chr17	31336729	Nonsense_Mutation	NA	L2081*	0.31
LGG	chr17	31357308	Nonsense_Mutation	rs786201367	R2637*	0.32
LGG	chr17	31249116	Frame_Shift_Del	novel	*Q1370Rfs8**	0.19
LGG	chr17	31229967	Frame_Shift_Del	novel	*L995Wfs17**	0.27
LGG	chr17	31350209	Nonsense_Mutation	rs786202457	R2450*	0.34
LGG	chr17	31338734	Frame_Shift_Del	NA	*Y2285Tfs5**	0.81
LGG	chr17	31259093	Missense_Mutation	rs786202492	N1465S	0.13
LGG	chr17	31350209	Nonsense_Mutation	rs786202457	R2450*	0.2
LGG	chr17	31356965	Frame_Shift_Ins	novel	*R2583Efs13**	0.16
LGG	chr17	31235621	Missense_Mutation	NA	A1240G	0.04
LGG	chr17	31235639	Frame_Shift_Del	NA	*F1247Ifs18**	0.78
LGG	chr17	31248983	Splice_Site	NA	X1325_splice	0.54
LGG	chr17	31225198	Nonsense_Mutation	NA	L650*	0.23
LGG	chr17	31235639	Frame_Shift_Del	NA	*F1247Ifs18**	0.27
LGG	chr17	31156042	Frame_Shift_Del	novel	*E41Sfs24**	0.41
LGG	chr17	31181460	Nonsense_Mutation	rs786203448	Q209*	0.35
LGG	chr17	31181782	Missense_Mutation	novel	A243T	0.28
LGG	chr17	31227579	Silent	novel	Y794Y	0.08
LGG	chr17	31260469	Missense_Mutation	novel	L1511F	0.37
LGG	chr17	31159019	Frame_Shift_Del	novel	*G72Efs13**	0.53
LGG	chr17	31229148	Missense_Mutation	NA	C845R	0.9
LGG	chr17	31229204	Nonsense_Mutation	novel	Y863*	0.38
LGG	chr17	31235639	Frame_Shift_Del	NA	*F1247Ifs18**	0.2
LGG	chr17	31340617	Frame_Shift_Del	novel	*D2346Vfs49**	0.07
LGG	chr17	31181778	Frame_Shift_Ins	novel	*M242Nfs3**	0.22
LGG	chr17	31338139	Splice_Region	NA	K2273K	0.42
LGG	chr17	31325956	Frame_Shift_Del	novel	*L1659Sfs39**	0.18
LGG	chr17	31235989	Nonsense_Mutation	NA	W1314*	0.42
LGG	chr17	31327498	Splice_Site	novel	X1757_splice	0.96
LGG	chr17	31235639	Frame_Shift_Del	NA	*F1247Ifs18**	0.1
LGG	chr17	31327839	Missense_Mutation	rs786202112	R1870Q	0.21
LGG	chr17	31336332	Splice_Site	NA	X2003_splice	0.09
LGG	chr17	31229851	Missense_Mutation	novel	T956I	0.15
LGG	chr17	31200552	Frame_Shift_Ins	novel	*V341Cfs12**	0.32
LGG	chr17	31357004	Nonsense_Mutation	novel	K2595*	0.2
LGG	chr17	31219018	Frame_Shift_Del	rs267606600	*Q514Rfs43**	0.44
LGG	chr17	31325958	Frame_Shift_Del	NA	*K1661Gfs36**	0.06
LGG	chr17	31343137	Splice_Site	NA	X2397_splice	0.12
LIHC	chr17	31227585	Missense_Mutation	NA	K796N	0.13
LIHC	chr17	31169936	Silent	rs750358089	H175H	0.33
LIHC	chr17	31265276	Missense_Mutation	NA	S1591N	0.38
LIHC	chr17	31233072	Missense_Mutation	novel	Q1189H	0.46
LIHC	chr17	31219235	Intron	novel		0.44
LIHC	chr17	31259100	Missense_Mutation	novel	F1467L	0.04
LIHC	chr17	31330454	In_Frame_Del	novel	T1923_L1927delinsM	0.29
LIHC	chr17	31260370	Frame_Shift_Del	NA	*F1479Sfs4**	0.29
LIHC	chr17	31226676	Missense_Mutation	NA	M748R	0.42
LIHC	chr17	31261763	Missense_Mutation	novel	A1544T	0.29
LIHC	chr17	31249120	Splice_Site	NA	X1370_splice	0.3
LIHC	chr17	31327637	Missense_Mutation	rs559910904	I1803V	0.53
LIHC	chr17	31214494	Frame_Shift_Del	novel	*K480Nfs18**	0.5
LIHC	chr17	31265300	Missense_Mutation	NA	S1599Y	0.06
LIHC	chr17	31330475	Frame_Shift_Ins	novel	*I1931Lfs12**	0.07
LUAD	chr17	31235747	Missense_Mutation	NA	S1282I	0.6
LUAD	chr17	31326002	Missense_Mutation	NA	N1673S	0.25
LUAD	chr17	31223514	Nonsense_Mutation	novel	K598*	0.73
LUAD	chr17	31230260	Missense_Mutation	NA	R997S	0.12
LUAD	chr17	31259088	Frame_Shift_Del	novel	*F1464Sfs5**	0.41
LUAD	chr17	31330500	Splice_Site	NA	X1938_splice	0.52
LUAD	chr17	31327496	Splice_Region	novel		0.28
LUAD	chr17	31350281	Missense_Mutation	novel	D2474N	0.1
LUAD	chr17	31200484	Frame_Shift_Del	NA	*E318Kfs11**	0.07
LUAD	chr17	31357370	Splice_Site	novel	X2657_splice	0.09
LUAD	chr17	31227572	Missense_Mutation	NA	L792H	0.51
LUAD	chr17	31337851	Nonsense_Mutation	NA	W2225*	0.18
LUAD	chr17	31214524	Missense_Mutation	rs137854557	Y489C	0.29
LUAD	chr17	31374192	3'UTR	novel		0.24
LUAD	chr17	31248983	Splice_Site	novel	X1325_splice	0.57
LUAD	chr17	31334876	Frame_Shift_Del	NA	*P1951Hfs6**	0.17
LUAD	chr17	31200468	Missense_Mutation	NA	G312A	0.36
LUAD	chr17	31226557	Silent	novel	S708S	0.08
LUAD	chr17	31214539	Nonsense_Mutation	NA	L494*	0.37
LUAD	chr17	31330469	Frame_Shift_Del	novel	*E1929Sfs13**	0.24
LUAD	chr17	31330470	Missense_Mutation	novel	E1928D	0.25
LUAD	chr17	31163300	Frame_Shift_Del	novel	*R135Ifs29**	0.45
LUAD	chr17	31232863	Frame_Shift_Del	novel	*G1160Vfs6**	0.31
LUAD	chr17	31327646	Nonsense_Mutation	NA	Q1806*	0.33
LUAD	chr17	31221865	Missense_Mutation	NA	H553Y	0.79
LUAD	chr17	31201156	Silent	rs786202581	F394F	0.17
LUAD	chr17	31235916	Splice_Site	novel	X1291_splice	0.21
LUAD	chr17	31336427	Missense_Mutation	NA	T2034I	0.23
LUAD	chr17	31330331	Missense_Mutation	NA	C1882Y	0.38
LUAD	chr17	31374257	3'UTR	novel		0.13
LUAD	chr17	31374259	3'UTR	novel		0.13
LUAD	chr17	31232699	Splice_Site	novel	X1105_splice	0.34
LUAD	chr17	31249085	Frame_Shift_Ins	novel	*Q1360Sfs20**	0.19
LUAD	chr17	31330331	Missense_Mutation	NA	C1882F	0.43
LUAD	chr17	31330333	Missense_Mutation	novel	T1883P	0.43
LUAD	chr17	31350305	Missense_Mutation	NA	D2482N	0.18
LUAD	chr17	31235617	Silent	novel	L1239L	0.11
LUAD	chr17	31327673	Nonsense_Mutation	NA	Q1815*	0.09
LUAD	chr17	31335017	Nonsense_Mutation	novel	G1998*	0.08
LUAD	chr17	31336672	Missense_Mutation	novel	C2062S	0.21
LUAD	chr17	31325835	Missense_Mutation	novel	Q1617H	0.28
LUAD	chr17	31343015	Nonsense_Mutation	NA	E2357*	0.25
LUAD	chr17	31336751	Silent	NA	L2088L	0.16
LUAD	chr17	31163273	Nonsense_Mutation	NA	E126*	0.28
LUAD	chr17	31226684	Nonsense_Mutation	NA	G751*	0.62
LUAD	chr17	31232863	Missense_Mutation	rs786202815	G1160C	0.13
LUAD	chr17	31337503	Missense_Mutation	NA	S2188F	0.96
LUAD	chr17	31159046	Missense_Mutation	NA	L81V	0.14
LUAD	chr17	31325914	Missense_Mutation	novel	D1644Y	0.55
LUAD	chr17	31201409	Splice_Site	NA	X396_splice	0.41
LUAD	chr17	31337528	Frame_Shift_Del	NA	*F2197Cfs44**	0.25
LUAD	chr17	31336874	Silent	rs786203078	I2129I	0.06
LUAD	chr17	31229451	Missense_Mutation	novel	D946Y	0.14
LUAD	chr17	31374114	Missense_Mutation	novel	A2827P	0.28
LUAD	chr17	31325987	Missense_Mutation	NA	G1668V	0.25
LUAD	chr17	31340505	Frame_Shift_Del	novel	*D2308Afs17**	0.5
LUAD	chr17	31229356	Missense_Mutation	NA	R914L	0.26
LUAD	chr17	31327840	Splice_Site	NA	X1870_splice	0.62
LUAD	chr17	31327723	Frame_Shift_Ins	novel	E1832*	0.19
LUAD	chr17	31334864	Nonsense_Mutation	rs587782088	E1947*	0.2
LUAD	chr17	31235703	Frame_Shift_Del	novel	*A1268Qfs17**	0.22
LUAD	chr17	31352412	Frame_Shift_Del	novel	*G2539Efs9**	0.27
LUAD	chr17	31338703	Splice_Site	NA	X2274_splice	0.21
LUAD	chr17	31221848	Splice_Site	NA	X548_splice	0.46
LUAD	chr17	31223443	Splice_Site	novel	X574_splice	0.21
LUAD	chr17	31233129	Missense_Mutation	NA	L1208F	0.23
LUAD	chr17	31340586	Missense_Mutation	NA	T2335P	0.65
LUAD	chr17	31336396	Nonsense_Mutation	NA	G2024*	0.11
LUAD	chr17	31358968	Splice_Site	novel	X2705_splice	0.14
LUAD	chr17	31358969	Missense_Mutation	novel	S2705I	0.14
LUAD	chr17	31343135	Missense_Mutation	novel	G2397W	0.28
LUAD	chr17	31327674	Missense_Mutation	NA	Q1815L	0.35
LUAD	chr17	31337490	Missense_Mutation	NA	D2184N	0.16
LUAD	chr17	31229777	Intron	novel		0.11
LUAD	chr17	31229934	Missense_Mutation	novel	G984W	0.12
LUAD	chr17	31338737	Nonsense_Mutation	novel	Y2285*	0.14
LUAD	chr17	31229130	Missense_Mutation	novel	N839Y	0.21
LUAD	chr17	31349191	Frame_Shift_Del	novel	*N2421Tfs11**	0.39
LUAD	chr17	31225157	Frame_Shift_Del	novel	*S637Vfs51**	0.23
LUAD	chr17	31337459	Silent	NA	A2173A	0.19
LUAD	chr17	31226437	Splice_Region	NA	D668D	0.39
LUAD	chr17	31258400	Frame_Shift_Del	novel	*L1411Sfs17**	0.08
LUSC	chr17	31343007	Splice_Site	NA	X2355_splice	0.55
LUSC	chr17	31235947	Silent	novel	L1300L	0.07
LUSC	chr17	31229967	Silent	novel	L995L	0.16
LUSC	chr17	31229229	Nonsense_Mutation	novel	E872*	0.66
LUSC	chr17	31227522	Splice_Site	NA	X776_splice	0.39
LUSC	chr17	31159050	Missense_Mutation	NA	S82C	0.09
LUSC	chr17	31358510	Silent	NA	T2667T	0.21
LUSC	chr17	31358512	Missense_Mutation	NA	L2668Q	0.21
LUSC	chr17	31206372	Splice_Site	NA	X464_splice	0.42
LUSC	chr17	31327676	Nonsense_Mutation	novel	E1816*	0.11
LUSC	chr17	31336808	Frame_Shift_Ins	novel	*T2108Nfs12**	0.17
LUSC	chr17	31225101	Missense_Mutation	novel	D618N	0.49
LUSC	chr17	31350233	Nonsense_Mutation	novel	R2458*	0.92
LUSC	chr17	31340574	Missense_Mutation	novel	Y2331H	0.67
LUSC	chr17	31337867	Nonsense_Mutation	NA	E2231*	0.7
LUSC	chr17	31181458	Missense_Mutation	novel	A208E	0.13
LUSC	chr17	31357036	Missense_Mutation	NA	L2605F	0.17
LUSC	chr17	31334931	Frame_Shift_Del	novel	*R1970Sfs6**	0.56
LUSC	chr17	31221863	Missense_Mutation	novel	L552R	0.49
LUSC	chr17	31374101	Missense_Mutation	NA	Q2822H	0.18
LUSC	chr17	31337401	Frame_Shift_Del	novel	*E2155Vfs4**	0.19
LUSC	chr17	31182549	Nonsense_Mutation	NA	E258*	0.23
LUSC	chr17	31335027	Missense_Mutation	novel	G2001V	0.36
LUSC	chr17	31200540	Nonsense_Mutation	NA	W336*	0.37
LUSC	chr17	31221904	Missense_Mutation	NA	P566A	0.07
LUSC	chr17	31327543	Missense_Mutation	novel	K1771N	0.3
LUSC	chr17	31201423	Nonsense_Mutation	NA	Q400*	0.23
LUSC	chr17	31163270	Missense_Mutation	novel	R125C	0.11
LUSC	chr17	31337476	Missense_Mutation	rs772639479	R2179L	0.22
LUSC	chr17	31219148	Intron	novel		0.35
LUSC	chr17	31334966	Missense_Mutation	rs762935987	M1981V	0.3
LUSC	chr17	31156096	Silent	NA	L58L	0.21
LUSC	chr17	31214524	Missense_Mutation	rs137854557	Y489C	0.33
LUSC	chr17	31327648	Frame_Shift_Del	novel	*G1807Afs56**	0.68
LUSC	chr17	31214502	Missense_Mutation	rs770201871	T482A	0.35
LUSC	chr17	31349247	Missense_Mutation	NA	L2439F	0.37
LUSC	chr17	31156049	Silent	novel	L43L	0.34
LUSC	chr17	31232713	Missense_Mutation	novel	F1110V	0.23
LUSC	chr17	31260379	Missense_Mutation	NA	D1481H	0.04
LUSC	chr17	31334853	Frame_Shift_Del	novel	*H1943Rfs17**	0.12
LUSC	chr17	31233157	Nonsense_Mutation	NA	Q1218*	0.36
LUSC	chr17	31229518	Intron	novel		0.27
LUSC	chr17	31327821	Missense_Mutation	novel	S1864I	0.19
LUSC	chr17	31258468	In_Frame_Del	novel	P1433_M1442delinsL	0.2
LUSC	chr17	31229382	Missense_Mutation	NA	L923V	0.42
LUSC	chr17	31265317	Missense_Mutation	rs199474766	I1605V	0.12
LUSC	chr17	31169954	Missense_Mutation	NA	Q181H	0.15
LUSC	chr17	31357278	Missense_Mutation	novel	V2627L	0.42
LUSC	chr17	31338739	Nonsense_Mutation	rs772295894	Y2285*	0.13
LUSC	chr17	31235648	Frame_Shift_Del	novel	*R1250Lfs10**	0.15
LUSC	chr17	31229327	Nonsense_Mutation	NA	C904*	0.61
LUSC	chr17	31352349	Missense_Mutation	novel	R2517L	0.47
LUSC	chr17	31259122	Missense_Mutation	novel	A1475T	0.25
LUSC	chr17	31356561	Missense_Mutation	novel	A2573S	0.46
LUSC	chr17	31156031	Nonsense_Mutation	novel	E37*	0.09
LUSC	chr17	31159076	Nonsense_Mutation	novel	E91*	0.61
LUSC	chr17	31200565	Silent	rs199832006	L344L	0.4
LUSC	chr17	31326185	Missense_Mutation	NA	E1734V	0.44
LUSC	chr17	31336914	Frame_Shift_Del	novel		0.27
LUSC	chr17	31226459	Frame_Shift_Ins	rs780157990	*I679Dfs21**	0.48
LUSC	chr17	31330351	Nonsense_Mutation	NA	E1889*	0.43
LUSC	chr17	31163323	Silent	novel	L142L	0.36
LUSC	chr17	31357294	Missense_Mutation	NA	D2632V	0.5
LUSC	chr17	31326009	Silent	rs17878418	S1675S	0.18
LUSC	chr17	31229040	Missense_Mutation	novel	H809N	0.26
LUSC	chr17	31352273	Nonsense_Mutation	NA	Q2492*	0.04
LUSC	chr17	31229859	Nonsense_Mutation	NA	Q959*	0.22
MESO	chr17	31374198	3'UTR	novel		0.2
OV	chr17	31229063	Frame_Shift_Del	novel	*M817Cfs4**	0.76
OV	chr17	31214515	Frame_Shift_Del	novel	*R487Wfs2**	0.04
OV	chr17	31334870	Frame_Shift_Del	NA	*M1949Ifs2**	0.67
OV	chr17	31336771	Frame_Shift_Ins	NA	*V2096Cfs24**	0.79
OV	chr17	31374082	Missense_Mutation	novel	G2816A	0.39
OV	chr17	31163231	Nonsense_Mutation	NA	Q112*	0.77
OV	chr17	31338092	Nonsense_Mutation	NA	R2258*	0.64
OV	chr17	31226572	Silent	novel	L713L	0.05
OV	chr17	31159057	Frame_Shift_Del	NA	*I85Kfs12**	0.58
OV	chr17	31326172	Missense_Mutation	NA	T1730P	0.38
OV	chr17	31232859	Frame_Shift_Del	NA	*S1159Tfs3**	0.22
OV	chr17	31258500	Missense_Mutation	rs137854550	K1444E	0.76
OV	chr17	31159042	Frame_Shift_Ins	NA	*Y80Lfs27**	0.91
OV	chr17	31230318	Nonsense_Mutation	NA	Q1017*	0.63
OV	chr17	31221857	Missense_Mutation	NA	L550P	0.46
OV	chr17	31182507	Splice_Site	NA	X244_splice	0.39
OV	chr17	31327802	Missense_Mutation	rs786203416	A1858T	0.59
OV	chr17	31159045	Frame_Shift_Del	novel	Q83*	0.44
OV	chr17	31259032	Frame_Shift_Del	NA	*I1445Sfs20**	0.88
OV	chr17	31169992	Missense_Mutation	NA	L194P	0.6
OV	chr17	31343008	Splice_Site	NA	X2355_splice	0.21
OV	chr17	31260344	Splice_Site	NA	X1477_splice	0.13
OV	chr17	31249116	Nonsense_Mutation	NA	Y1369*	0.24
OV	chr17	31337580	Nonsense_Mutation	NA	E2214*	0.87
OV	chr17	31327587	Nonsense_Mutation	NA	S1786*	0.55
OV	chr17	31214456	Frame_Shift_Ins	rs778963145	*T467Nfs3**	0.61
OV	chr17	31265251	Nonsense_Mutation	NA	E1583*	0.77
OV	chr17	31156102	Splice_Site	novel	X62_splice	0.89
OV	chr17	31229118	Nonsense_Mutation	novel	Q835*	0.33
OV	chr17	31327818	Missense_Mutation	NA	G1863A	0.69
OV	chr17	31206365	Frame_Shift_Del	novel	*A463Hfs10**	0.71
OV	chr17	31230314	Frame_Shift_Del	novel	*C1016Vfs3**	0.76
PAAD	chr17	31249071	Silent	novel	S1354S	0.03
PAAD	chr17	31338100	Silent	novel	S2260S	0.08
PAAD	chr17	31159031	Frame_Shift_Ins	novel	*N78Kfs29**	0.08
PAAD	chr17	31334897	Missense_Mutation	NA	R1958C	0.17
PAAD	chr17	31334939	Missense_Mutation	novel	T1972A	0.2
PAAD	chr17	31229960	Missense_Mutation	novel	M992I	0.32
PCPG	chr17	31230280	Frame_Shift_Del	novel	*N1004Ifs3**	0.15
PCPG	chr17	31225196	Frame_Shift_Ins	novel	*L650Vfs20**	0.79
PCPG	chr17	31349156	Frame_Shift_Del	novel	*V2410Efs7**	0.78
PCPG	chr17	31340509	Frame_Shift_Del	novel	*P2310Sfs16**	0.48
PCPG	chr17	31249044	Frame_Shift_Del	novel	*F1346Sfs27**	0.29
PCPG	chr17	31330320	Nonsense_Mutation	novel	C1878*	0.36
PCPG	chr17	31169975	Frame_Shift_Del	novel	*K189Nfs2**	0.63
PCPG	chr17	31326245	Frame_Shift_Del	novel	*S1754Lfs11**	0.88
PCPG	chr17	31214586	Splice_Site	NA	X509_splice	0.71
PCPG	chr17	31229974	Missense_Mutation	novel	R997T	0.77
PCPG	chr17	31201463	Nonsense_Mutation	novel	S413*	0.45
PCPG	chr17	31206263	Frame_Shift_Del	novel	*K428Nfs41**	0.7
PCPG	chr17	31223422	Splice_Site	novel	X574_splice	0.67
PCPG	chr17	31214530	Frame_Shift_Ins	novel	*L492Ffs7**	0.64
PCPG	chr17	31261725	Frame_Shift_Del	novel	*G1532Efs42**	0.69
PCPG	chr17	31227547	Missense_Mutation	novel	W784R	0.43
PCPG	chr17	31201423	Nonsense_Mutation	NA	Q400*	0.78
PCPG	chr17	31229233	Frame_Shift_Ins	novel	K874*	0.74
PRAD	chr17	31163345	Frame_Shift_Del	novel	*F150Sfs15**	0.2
PRAD	chr17	31336456	Missense_Mutation	novel	K2044E	0.11
READ	chr17	31169986	Missense_Mutation	rs587781670	R192Q	0.28
READ	chr17	31206298	Missense_Mutation	NA	R440Q	0.28
READ	chr17	31230308	Silent	NA	T1013T	0.2
READ	chr17	31230308	Silent	NA	T1013T	0.12
READ	chr17	31229505	Intron	novel		0.05
READ	chr17	31330331	Missense_Mutation	NA	C1882Y	0.08
READ	chr17	31235757	Missense_Mutation	NA	M1285I	0.15
READ	chr17	31229873	Missense_Mutation	NA	Q963H	0.11
READ	chr17	31182507	Splice_Site	NA	X244_splice	0.42
READ	chr17	31206297	Nonsense_Mutation	rs778405030	R440*	0.39
READ	chr17	31206298	Missense_Mutation	NA	R440Q	0.41
READ	chr17	31261722	Missense_Mutation	novel	A1530D	0.35
READ	chr17	31265325	Nonsense_Mutation	novel	Y1607*	0.39
READ	chr17	31357043	Nonsense_Mutation	novel	E2608*	0.09
READ	chr17	31327587	Missense_Mutation	NA	S1786L	0.38
READ	chr17	31325879	Missense_Mutation	novel	K1632T	0.15
READ	chr17	31343046	Missense_Mutation	NA	L2367Q	0.53
SARC	chr17	31214569	Frame_Shift_Ins	novel	*L506Afs5**	0.2
SARC	chr17	31200452	Frame_Shift_Ins	novel	*A308Cfs7**	0.96
SARC	chr17	31340592	Frame_Shift_Del	novel	*L2337Ffs9**	0.88
SARC	chr17	31340594	In_Frame_Del	novel	E2339_L2345del	0.81
SARC	chr17	31233015	Missense_Mutation	novel	H1170Q	0.1
SARC	chr17	31337795	Splice_Site	novel	X2215_splice	0.69
SARC	chr17	31375013	3'UTR	novel		0.04
SARC	chr17	31375013	3'UTR	novel		0.02
SARC	chr17	31249093	Nonsense_Mutation	rs137854560	R1362*	0.27
SARC	chr17	31226517	Frame_Shift_Del	novel	*L695Rfs8**	0.41
SARC	chr17	31375013	3'UTR	novel		0.09
SARC	chr17	31226460	Frame_Shift_Del	rs747195556	*P678Rfs10**	0.77
SARC	chr17	31375013	3'UTR	novel		0.24
SARC	chr17	31377228	3'UTR	novel		0.85
SARC	chr17	31225126	Frame_Shift_Del	novel	*Y628Tfs3**	0.22
SARC	chr17	31261822	Silent	novel	N1563N	0.32
SARC	chr17	31261823	Missense_Mutation	novel	L1564F	0.32
SARC	chr17	31226684	Missense_Mutation	novel	G751R	0.48
SARC	chr17	31375013	3'UTR	novel		0.12
SARC	chr17	31343070	Frame_Shift_Del	novel	*D2375Efs3**	0.21
SKCM	chr17	31327839	Missense_Mutation	rs786202112	R1870Q	0.59
SKCM	chr17	31327840	Splice_Site	NA	X1870_splice	0.61
SKCM	chr17	31338035	Nonsense_Mutation	NA	Q2239*	0.59
SKCM	chr17	31260375	Silent	novel	F1479F	0.13
SKCM	chr17	31229456	Silent	NA	S947S	0.32
SKCM	chr17	31232725	Missense_Mutation	NA	L1114M	0.29
SKCM	chr17	31258353	Nonsense_Mutation	novel	Q1395*	0.36
SKCM	chr17	31326174	Silent	novel	T1730T	0.38
SKCM	chr17	31206297	Nonsense_Mutation	rs778405030	R440*	0.41
SKCM	chr17	31219032	Nonsense_Mutation	NA	Q519*	0.2
SKCM	chr17	31338004	Intron	novel		0.21
SKCM	chr17	31357031	Missense_Mutation	NA	L2604F	0.54
SKCM	chr17	31352286	Missense_Mutation	NA	S2496F	0.06
SKCM	chr17	31357059	Missense_Mutation	rs750972729	P2613L	0.21
SKCM	chr17	31227548	Nonsense_Mutation	NA	W784*	0.14
SKCM	chr17	31227549	Nonsense_Mutation	novel	W784*	0.15
SKCM	chr17	31159009	Splice_Site	NA	X69_splice	0.28
SKCM	chr17	31182597	Missense_Mutation	NA	L274F	0.49
SKCM	chr17	31201444	Missense_Mutation	novel	H407Y	0.27
SKCM	chr17	31227232	Nonsense_Mutation	NA	Q756*	0.49
SKCM	chr17	31338805	Splice_Region	NA	K2307K	0.24
SKCM	chr17	31352362	Silent	novel	S2521S	0.24
SKCM	chr17	31182621	Nonsense_Mutation	NA	Q282*	0.32
SKCM	chr17	31226520	Nonsense_Mutation	NA	W696*	0.28
SKCM	chr17	31249093	Nonsense_Mutation	rs137854560	R1362*	0.37
SKCM	chr17	31226483	Nonsense_Mutation	NA	Q684*	0.38
SKCM	chr17	31265300	Missense_Mutation	NA	S1599F	0.51
SKCM	chr17	31226483	Nonsense_Mutation	NA	Q684*	0.28
SKCM	chr17	31327673	Nonsense_Mutation	NA	Q1815*	0.24
SKCM	chr17	31200572	Nonsense_Mutation	NA	Q347*	0.38
SKCM	chr17	31221849	Splice_Site	NA	X548_splice	0.17
SKCM	chr17	31229401	Missense_Mutation	NA	L929P	0.55
SKCM	chr17	31229113	Missense_Mutation	NA	S833F	0.65
SKCM	chr17	31325970	Nonsense_Mutation	NA	W1662*	0.18
SKCM	chr17	31327487	Splice_Site	novel	X1757_splice	0.6
SKCM	chr17	31200464	Nonsense_Mutation	NA	G311*	0.91
SKCM	chr17	31206297	Nonsense_Mutation	rs778405030	R440*	0.52
SKCM	chr17	31343008	Splice_Site	novel	X2355_splice	0.16
SKCM	chr17	31360664	Missense_Mutation	novel	N2780D	0.22
SKCM	chr17	31206297	Nonsense_Mutation	rs778405030	R440*	0.91
SKCM	chr17	31352348	Nonsense_Mutation	NA	R2517*	0.47
SKCM	chr17	31233199	Missense_Mutation	NA	P1232A	0.28
SKCM	chr17	31335016	Nonsense_Mutation	NA	W1997*	0.37
SKCM	chr17	31338739	Nonsense_Mutation	rs772295894	Y2285*	0.2
SKCM	chr17	31229145	Missense_Mutation	rs199474785	L844F	0.49
SKCM	chr17	31327839	Missense_Mutation	rs786202112	R1870Q	0.35
SKCM	chr17	31327840	Splice_Site	NA	X1870_splice	0.34
SKCM	chr17	31201116	Frame_Shift_Del	novel	*C383Yfs10**	0.5
SKCM	chr17	31356959	Splice_Site	NA	X2580_splice	0.44
SKCM	chr17	31334880	Nonsense_Mutation	NA	W1952*	0.73
SKCM	chr17	31233063	Silent	novel	I1186I	0.32
SKCM	chr17	31159045	Nonsense_Mutation	NA	Y80*	0.19
SKCM	chr17	31229465	Splice_Region	NA	Q950Q	0.29
SKCM	chr17	31235729	Missense_Mutation	rs137854556	R1276Q	0.08
SKCM	chr17	31327781	Missense_Mutation	rs267604793	P1851S	0.12
SKCM	chr17	31229115	Silent	NA	L834L	0.33
SKCM	chr17	31334986	Silent	rs757536610	Q1987Q	0.46
SKCM	chr17	31225188	Missense_Mutation	rs776251084	H647Y	0.24
SKCM	chr17	31229145	Missense_Mutation	rs199474785	L844F	0.66
SKCM	chr17	31358492	Silent	NA	L2661L	0.18
SKCM	chr17	31325859	Nonsense_Mutation	NA	Y1625*	0.51
SKCM	chr17	31232830	Missense_Mutation	novel	M1149V	0.25
SKCM	chr17	31235676	Nonsense_Mutation	NA	W1258*	0.88
SKCM	chr17	31338035	Nonsense_Mutation	NA	Q2239*	0.47
SKCM	chr17	31258343	Splice_Site	novel	X1392_splice	0.23
SKCM	chr17	31337403	Frame_Shift_Del	novel	*E2155Sfs45**	0.21
SKCM	chr17	31229407	Missense_Mutation	NA	P931L	0.55
SKCM	chr17	31229172	Nonsense_Mutation	NA	Q853*	0.7
SKCM	chr17	31223533	Nonsense_Mutation	NA	L604*	0.33
SKCM	chr17	31156068	Missense_Mutation	novel	Y49F	0.29
SKCM	chr17	31156069	Silent	novel	Y49Y	0.31
SKCM	chr17	31225134	Missense_Mutation	rs199474738	G629R	1
SKCM	chr17	31226576	Nonsense_Mutation	novel	E715*	0.14
SKCM	chr17	31259071	Missense_Mutation	novel	E1458K	0.38
SKCM	chr17	31230308	Silent	NA	T1013T	0.27
SKCM	chr17	31233006	Frame_Shift_Del	novel	*Y1169Sfs22**	0.87
SKCM	chr17	31374149	Silent	NA	I2838I	0.31
SKCM	chr17	31327780	Silent	novel	V1850V	0.44
SKCM	chr17	31326245	Missense_Mutation	NA	S1754F	0.22
SKCM	chr17	31327702	Silent	NA	I1824I	0.23
SKCM	chr17	31235723	Missense_Mutation	NA	L1274H	0.49
SKCM	chr17	31360587	Missense_Mutation	NA	S2754F	0.07
SKCM	chr17	31260397	Missense_Mutation	NA	P1487S	0.43
SKCM	chr17	31352286	Missense_Mutation	NA	S2496F	0.18
SKCM	chr17	31206297	Nonsense_Mutation	rs778405030	R440*	0.27
SKCM	chr17	31235948	Silent	NA	L1301L	0.3
SKCM	chr17	31327694	Nonsense_Mutation	NA	Q1822*	0.45
SKCM	chr17	31325983	Missense_Mutation	novel	P1667S	0.26
SKCM	chr17	31235623	Nonsense_Mutation	rs137854562	R1241*	0.16
SKCM	chr17	31357017	Missense_Mutation	NA	S2599F	0.12
SKCM	chr17	31226456	Missense_Mutation	novel	G675R	0.31
SKCM	chr17	31226524	Frame_Shift_Del	novel	*P698Lfs50**	0.76
SKCM	chr17	31336915	Splice_Site	novel	X2143_splice	0.48
SKCM	chr17	31230891	Nonsense_Mutation	NA	Q1055*	0.21
SKCM	chr17	31226459	Frame_Shift_Ins	rs780157990	*I679Dfs21**	0.89
SKCM	chr17	31337366	Splice_Site	NA	X2143_splice	0.58
SKCM	chr17	31200540	Nonsense_Mutation	NA	W336*	0.29
SKCM	chr17	31200541	Nonsense_Mutation	NA	W336*	0.29
SKCM	chr17	31350266	Nonsense_Mutation	novel	E2469*	0.45
SKCM	chr17	31182621	Nonsense_Mutation	NA	Q282*	0.23
SKCM	chr17	31232083	Nonsense_Mutation	rs786202023	Q1070*	0.25
SKCM	chr17	31214531	Nonsense_Mutation	novel	Y491*	0.69
SKCM	chr17	31214532	Missense_Mutation	novel	L492I	0.69
SKCM	chr17	31338124	Silent	NA	I2268I	0.37
SKCM	chr17	31358532	Missense_Mutation	NA	P2675S	0.27
SKCM	chr17	31163282	Nonsense_Mutation	novel	Q129*	0.74
SKCM	chr17	31159093	Splice_Region	NA	G96G	0.37
SKCM	chr17	31206297	Nonsense_Mutation	rs778405030	R440*	0.38
SKCM	chr17	31352415	Splice_Site	NA	X2539_splice	0.42
SKCM	chr17	31226526	Missense_Mutation	NA	P698L	0.26
SKCM	chr17	31200552	Frame_Shift_Ins	novel	*V341Cfs12**	0.39
STAD	chr17	31182616	Missense_Mutation	NA	I280T	0.32
STAD	chr17	31159039	Frame_Shift_Del	novel	*L79Yfs6**	0.25
STAD	chr17	31225133	Silent	rs555635097	Y628Y	0.17
STAD	chr17	31330360	Missense_Mutation	NA	L1892V	0.45
STAD	chr17	31360518	In_Frame_Del	novel	V2732del	0.28
STAD	chr17	31327684	Silent	NA	E1818E	0.24
STAD	chr17	31327757	In_Frame_Del	novel	T1843_K1844del	0.13
STAD	chr17	31350226	Frame_Shift_Del	novel	*K2456Nfs33**	0.16
STAD	chr17	31229062	In_Frame_Del	novel	R816_S818delinsP	0.09
STAD	chr17	31226459	Frame_Shift_Ins	rs780157990	*I679Dfs21**	0.69
STAD	chr17	31206360	Nonsense_Mutation	NA	R461*	0.46
STAD	chr17	31358526	Nonsense_Mutation	NA	Q2673*	0.36
STAD	chr17	31360670	Missense_Mutation	NA	M2782V	0.29
STAD	chr17	31229974	Missense_Mutation	NA	R997M	0.24
STAD	chr17	31357280	Frame_Shift_Del	novel	*K2628Nfs16**	0.38
STAD	chr17	31214463	Missense_Mutation	NA	K469Q	0.44
STAD	chr17	31358977	Missense_Mutation	NA	F2708V	0.31
STAD	chr17	31229200	Missense_Mutation	novel	T862I	0.16
STAD	chr17	31260368	Splice_Site	novel	X1477_splice	0.14
STAD	chr17	31337476	Missense_Mutation	novel	R2179H	0.06
STAD	chr17	31326174	Silent	NA	T1730T	0.06
STAD	chr17	31327675	Silent	novel	Q1815Q	0.49
STAD	chr17	31219155	Intron	novel		0.13
STAD	chr17	31349211	Silent	novel	D2427D	0.15
STAD	chr17	31336461	Missense_Mutation	novel	L2045F	0.33
STAD	chr17	31335022	Silent	NA	S1999S	0.15
STAD	chr17	31338126	Missense_Mutation	rs562367786	R2269H	0.34
STAD	chr17	31338000	Intron	novel		0.1
STAD	chr17	31229355	Missense_Mutation	rs765848298	R914W	0.16
STAD	chr17	31169985	Nonsense_Mutation	rs397514641	R192*	0.38
STAD	chr17	31229357	Silent	NA	R914R	0.07
STAD	chr17	31350267	Frame_Shift_Del	novel	*N2470Mfs19**	0.31
STAD	chr17	31233156	Missense_Mutation	novel	D1217E	0.13
STAD	chr17	31235664	Nonsense_Mutation	novel	Y1254*	0.56
STAD	chr17	31337557	Missense_Mutation	novel	T2206R	0.5
STAD	chr17	31206298	Missense_Mutation	novel	R440P	0.17
STAD	chr17	31260381	Missense_Mutation	NA	D1481E	0.33
STAD	chr17	31265317	Frame_Shift_Ins	novel	*Y1607Lfs15**	0.3
STAD	chr17	31327839	Missense_Mutation	rs786202112	R1870Q	0.16
STAD	chr17	31223535	Missense_Mutation	NA	I605F	0.13
STAD	chr17	31374233	3'UTR	novel		0.29
STAD	chr17	31201472	Missense_Mutation	novel	R416Q	0.38
STAD	chr17	31350300	Missense_Mutation	rs371151718	H2480R	0.16
STAD	chr17	31223496	Missense_Mutation	NA	S592G	0.23
STAD	chr17	31232856	Silent	NA	V1157V	0.1
STAD	chr17	31374105	Nonsense_Mutation	NA	Q2824*	0.23
STAD	chr17	31181474	Frame_Shift_Del	novel	N214*	0.53
STAD	chr17	31225225	Missense_Mutation	rs151138158	R659Q	0.06
STAD	chr17	31225126	Frame_Shift_Del	novel	*Y628Tfs3**	0.24
STAD	chr17	31230874	Missense_Mutation	novel	V1049A	0.15
STAD	chr17	31249057	Missense_Mutation	NA	I1350V	0.45
STAD	chr17	31326010	Missense_Mutation	rs756450772	A1676T	0.53
STAD	chr17	31374233	3'UTR	novel		0.5
TGCT	chr17	31200552	Missense_Mutation	rs771089333	S340C	0.27
TGCT	chr17	31169921	Silent	novel	D170D	0.12
TGCT	chr17	31159032	Frame_Shift_Del	novel	*N78Ffs28**	0.17
THCA	chr17	31219156	Intron	novel		0.54
THYM	chr17	31375013	3'UTR	novel		0.09
THYM	chr17	31350265	Missense_Mutation	novel	M2468I	0.17
THYM	chr17	31350266	Nonsense_Mutation	novel	E2469*	0.17
THYM	chr17	31375013	3'UTR	novel		0.1
THYM	chr17	31356562	Missense_Mutation	novel	A2573G	0.07
THYM	chr17	31375013	3'UTR	novel		0.03
THYM	chr17	31375013	3'UTR	novel		0.08
THYM	chr17	31358571	Missense_Mutation	novel	V2688M	0.55
UCEC	chr17	31159031	Frame_Shift_Ins	novel	*N78Kfs29**	0.57
UCEC	chr17	31206297	Nonsense_Mutation	rs778405030	R440*	0.35
UCEC	chr17	31350209	Nonsense_Mutation	rs786202457	R2450*	0.36
UCEC	chr17	31214577	Missense_Mutation	NA	L507V	0.28
UCEC	chr17	31337409	Missense_Mutation	NA	S2157P	0.28
UCEC	chr17	31360529	Missense_Mutation	NA	L2735I	0.33
UCEC	chr17	31219076	Silent	novel	V533V	0.47
UCEC	chr17	31232098	Missense_Mutation	novel	A1075S	0.09
UCEC	chr17	31340503	Splice_Site	novel	X2308_splice	0.11
UCEC	chr17	31357071	Missense_Mutation	rs375990655	A2617V	0.35
UCEC	chr17	31337503	Missense_Mutation	NA	S2188F	0.27
UCEC	chr17	31235706	Silent	novel	A1268A	0.41
UCEC	chr17	31326113	Missense_Mutation	novel	D1710G	0.47
UCEC	chr17	31337867	Nonsense_Mutation	NA	E2231*	0.29
UCEC	chr17	31356513	Nonsense_Mutation	novel	Q2557*	0.4
UCEC	chr17	31374592	3'UTR	novel		0.31
UCEC	chr17	31375029	3'UTR	novel		0.24
UCEC	chr17	31229585	Intron	novel		0.37
UCEC	chr17	31159022	Nonsense_Mutation	NA	E73*	0.42
UCEC	chr17	31221936	Splice_Region	NA		0.36
UCEC	chr17	31327739	Missense_Mutation	rs771597781	D1837N	0.14
UCEC	chr17	31330312	Missense_Mutation	NA	L1876I	0.41
UCEC	chr17	31327824	Missense_Mutation	novel	S1865Y	0.25
UCEC	chr17	31214481	Missense_Mutation	novel	L475I	0.33
UCEC	chr17	31374912	3'UTR	novel		0.63
UCEC	chr17	31377177	3'UTR	novel		0.48
UCEC	chr17	31229130	Missense_Mutation	rs755956826	N839D	0.34
UCEC	chr17	31169961	Missense_Mutation	novel	N184D	0.42
UCEC	chr17	31182516	Nonsense_Mutation	novel	E247*	0.38
UCEC	chr17	31226437	Splice_Region	NA	D668D	0.32
UCEC	chr17	31336764	Missense_Mutation	novel	S2093A	0.42
UCEC	chr17	31229152	Missense_Mutation	novel	A846D	0.33
UCEC	chr17	31377450	3'UTR	rs9844		0.44
UCEC	chr17	31156055	Missense_Mutation	novel	N45D	0.33
UCEC	chr17	31206355	Missense_Mutation	novel	A459V	0.48
UCEC	chr17	31334891	Silent	novel	L1956L	0.48
UCEC	chr17	31360668	Missense_Mutation	novel	S2781F	0.36
UCEC	chr17	31377177	3'UTR	novel		0.41
UCEC	chr17	31201128	Missense_Mutation	novel	R385H	0.2
UCEC	chr17	31249093	Nonsense_Mutation	rs137854560	R1362*	0.32
UCEC	chr17	31258475	Silent	rs779865988	I1435I	0.24
UCEC	chr17	31350209	Nonsense_Mutation	rs786202457	R2450*	0.15
UCEC	chr17	31206360	Nonsense_Mutation	NA	R461*	0.41
UCEC	chr17	31249093	Nonsense_Mutation	rs137854560	R1362*	0.37
UCEC	chr17	31357314	Missense_Mutation	novel	L2639I	0.3
UCEC	chr17	31206361	Missense_Mutation	NA	R461Q	0.29
UCEC	chr17	31229717	Intron	novel		0.18
UCEC	chr17	31374081	Missense_Mutation	rs778233452	G2816R	0.44
UCEC	chr17	31374737	3'UTR	novel		0.26
UCEC	chr17	31163364	Missense_Mutation	rs754096545	R156H	0.25
UCEC	chr17	31181482	Missense_Mutation	rs199474756	L216P	0.21
UCEC	chr17	31233081	Missense_Mutation	NA	E1192D	0.11
UCEC	chr17	31258376	Silent	NA	I1402I	0.34
UCEC	chr17	31349169	Silent	NA	L2413L	0.22
UCEC	chr17	31350209	Nonsense_Mutation	rs786202457	R2450*	0.25
UCEC	chr17	31230279	Missense_Mutation	novel	N1004D	0.2
UCEC	chr17	31235964	Missense_Mutation	NA	R1306Q	0.22
UCEC	chr17	31340628	Missense_Mutation	rs56013763	R2349C	0.21
UCEC	chr17	31235932	Silent	novel	T1295T	0.24
UCEC	chr17	31330329	Silent	NA	T1881T	0.41
UCEC	chr17	31377177	3'UTR	novel		0.45
UCEC	chr17	31357071	Missense_Mutation	rs375990655	A2617V	0.2
UCEC	chr17	31374738	3'UTR	novel		0.52
UCEC	chr17	31219031	Silent	novel	T518T	0.46
UCEC	chr17	31229422	Missense_Mutation	novel	K936T	0.41
UCEC	chr17	31375239	3'UTR	novel		0.4
UCEC	chr17	31095053	5'UTR	novel		0.4
UCEC	chr17	31258475	Silent	rs779865988	I1435I	0.1
UCEC	chr17	31265251	Nonsense_Mutation	NA	E1583*	0.13
UCEC	chr17	31337423	Missense_Mutation	novel	F2161L	0.46
UCEC	chr17	31338113	Missense_Mutation	novel	K2265Q	0.15
UCEC	chr17	31377332	3'UTR	novel		0.1
UCEC	chr17	31200588	Missense_Mutation	novel	D352G	0.19
UCEC	chr17	31350184	Splice_Region	novel	A2441A	0.24
UCEC	chr17	31356459	Splice_Site	novel	X2539_splice	0.28
UCEC	chr17	31357275	Silent	novel	L2626L	0.25
UCEC	chr17	31375873	3'UTR	novel		0.08
UCEC	chr17	31374738	3'UTR	novel		0.34
UCEC	chr17	31159032	Frame_Shift_Del	NA	*N78Ifs7**	0.62
UCEC	chr17	31169999	Splice_Site	NA	X196_splice	0.5
UCEC	chr17	31249079	Frame_Shift_Ins	novel	*Q1360Sfs20**	0.48
UCEC	chr17	31200571	Silent	novel	V346V	0.39
UCEC	chr17	31381885	3'Flank	rs755946375		0.28
UCEC	chr17	31374653	3'UTR	novel		0.44
UCEC	chr17	31235692	Nonsense_Mutation	NA	E1264*	0.39
UCEC	chr17	31327739	Missense_Mutation	rs771597781	D1837N	0.09
UCEC	chr17	31350209	Nonsense_Mutation	rs786202457	R2450*	0.42
UCEC	chr17	31327609	Silent	novel	L1793L	0.5
UCEC	chr17	31350209	Nonsense_Mutation	rs786202457	R2450*	0.39
UCEC	chr17	31357320	Nonsense_Mutation	novel	E2641*	0.32
UCEC	chr17	31374159	3'UTR	novel		0.4
UCEC	chr17	31163364	Missense_Mutation	rs754096545	R156H	0.43
UCEC	chr17	31229650	Intron	novel		0.42
UCEC	chr17	31229817	Intron	novel		0.39
UCEC	chr17	31232780	Missense_Mutation	rs778920556	R1132H	0.44
UCEC	chr17	31249093	Nonsense_Mutation	rs137854560	R1362*	0.51
UCEC	chr17	31337823	Missense_Mutation	novel	C2216Y	0.45
UCEC	chr17	31222001	Intron	novel		0.27
UCEC	chr17	31206239	Splice_Site	novel	X421_splice	0.55
UCEC	chr17	31219047	Nonsense_Mutation	novel	E524*	0.53
UCEC	chr17	31326184	Nonsense_Mutation	NA	E1734*	0.44
UCEC	chr17	31327565	Silent	rs770078684	L1779L	0.34
UCEC	chr17	31336810	Missense_Mutation	novel	T2108N	0.48
UCEC	chr17	31338758	Nonsense_Mutation	novel	E2292*	0.41
UCEC	chr17	31350209	Nonsense_Mutation	rs786202457	R2450*	0.42
UCEC	chr17	31377332	3'UTR	novel		0.39
UCEC	chr17	31375371	3'UTR	novel		0.13
UCEC	chr17	31375027	3'UTR	novel		0.31
UCEC	chr17	31377344	3'UTR	rs548353495		0.44
UCEC	chr17	31374653	3'UTR	novel		0.37
UCEC	chr17	31375288	3'UTR	novel		0.45
UCEC	chr17	31375893	3'UTR	novel		0.8
UCEC	chr17	31327818	Missense_Mutation	novel	G1863D	0.71
UCEC	chr17	31225126	Frame_Shift_Del	novel	*Y628Tfs3**	0.23
UCEC	chr17	31330350	Silent	rs373685150	I1888I	0.24
UCEC	chr17	31229094	Missense_Mutation	novel	D827Y	0.35
UCEC	chr17	31252778	Intron	novel		0.5
UCEC	chr17	31265251	Nonsense_Mutation	NA	E1583*	0.25
UCEC	chr17	31350261	Nonsense_Mutation	novel	S2467*	0.31
UCEC	chr17	31357314	Missense_Mutation	novel	L2639I	0.53
UCEC	chr17	31367228	Intron	novel		0.29
UCEC	chr17	31377228	3'UTR	novel		0.68
UCEC	chr17	31377563	3'UTR	novel		0.43
UCEC	chr17	31227608	Splice_Site	novel	X803_splice	0.33
UCEC	chr17	31325909	Missense_Mutation	novel	V1642A	0.36
UCEC	chr17	31334958	Missense_Mutation	NA	L1978P	0.2
UCEC	chr17	31159032	Frame_Shift_Del	NA	*N78Ifs7**	0.45
UCEC	chr17	31225225	Missense_Mutation	rs151138158	R659Q	0.18
UCEC	chr17	31229670	Intron	novel		0.4
UCEC	chr17	31377545	3'UTR	novel		0.2
UCEC	chr17	31374653	3'UTR	novel		0.49
UCEC	chr17	31221931	Splice_Site	novel	X574_splice	0.42
UCEC	chr17	31225134	Missense_Mutation	rs199474738	G629R	0.58
UCEC	chr17	31374233	3'UTR	novel		0.43
UCEC	chr17	31374653	3'UTR	novel		0.44
UCEC	chr17	31258500	Missense_Mutation	rs137854550	K1444E	0.22
UCEC	chr17	31159032	Frame_Shift_Del	NA	*N78Ifs7**	0.28
UCEC	chr17	31327595	Missense_Mutation	NA	E1789K	0.45
UCEC	chr17	31219048	Missense_Mutation	novel	E524G	0.32
UCEC	chr17	31249093	Nonsense_Mutation	rs137854560	R1362*	0.34
UCEC	chr17	31330397	Missense_Mutation	novel	N1904S	0.3
UCEC	chr17	31337419	Missense_Mutation	novel	K2160T	0.26
UCEC	chr17	31374353	3'UTR	novel		0.24
UCEC	chr17	31163188	Splice_Region	novel	Q97Q	0.23
UCEC	chr17	31227259	Missense_Mutation	NA	R765C	0.59
UCEC	chr17	31229527	Intron	novel		0.36
UCEC	chr17	31232763	Missense_Mutation	novel	Q1126H	0.39
UCEC	chr17	31250074	Intron	novel		0.32
UCEC	chr17	31343037	Missense_Mutation	novel	R2364Q	0.36
UCEC	chr17	31375473	3'UTR	novel		0.41
UCEC	chr17	31377353	3'UTR	novel		0.38
UCEC	chr17	31227260	Missense_Mutation	NA	R765L	0.38
UCEC	chr17	31325835	Missense_Mutation	NA	Q1617H	0.4
UCEC	chr17	31226460	Frame_Shift_Del	rs747195556	*P678Rfs10**	0.42
UCEC	chr17	31227235	Frame_Shift_Del	novel	*R758Sfs9**	0.39
UCEC	chr17	31181763	Silent	novel	Q236Q	0.33
UCEC	chr17	31206372	Splice_Site	rs267604791	X464_splice	0.4
UCEC	chr17	31221896	Missense_Mutation	novel	P563H	0.3
UCEC	chr17	31229304	Missense_Mutation	rs775949348	R897W	0.25
UCEC	chr17	31325844	Silent	novel	G1620G	0.39
UCEC	chr17	31337430	Silent	novel	L2164L	0.42
UCEC	chr17	31375239	3'UTR	novel		0.61
UCEC	chr17	31377370	3'UTR	novel		0.47
UCEC	chr17	31156080	Nonsense_Mutation	NA	L53*	0.42
UCEC	chr17	31235728	Nonsense_Mutation	rs199474742	R1276*	0.46
UCEC	chr17	31206297	Nonsense_Mutation	rs778405030	R440*	0.38
UCEC	chr17	31219012	Missense_Mutation	novel	R512I	0.14
UCEC	chr17	31350209	Nonsense_Mutation	rs786202457	R2450*	0.52
UCEC	chr17	31337411	Silent	NA	S2157S	0.43
UCEC	chr17	31235964	Missense_Mutation	NA	R1306Q	0.07
UCEC	chr17	31260463	Missense_Mutation	NA	R1509C	0.26
UCEC	chr17	31265251	Nonsense_Mutation	NA	E1583*	0.3
UCEC	chr17	31214466	Nonsense_Mutation	NA	E470*	0.09
UCEC	chr17	31377241	3'UTR	novel		0.35
UCEC	chr17	31374738	3'UTR	novel		0.53
UCEC	chr17	31219044	Missense_Mutation	NA	A523S	0.17
UCEC	chr17	31249973	Intron	novel		0.13
UCEC	chr17	31258377	Missense_Mutation	rs138227618	G1403S	0.34
UCEC	chr17	31265259	Missense_Mutation	novel	K1585N	0.07
UCEC	chr17	31338062	Missense_Mutation	novel	A2248S	0.25
UCEC	chr17	31374698	3'UTR	novel		0.5
UCEC	chr17	31375717	3'UTR	novel		0.09
UCEC	chr17	31360702	Splice_Region	novel	P2792P	0.38
UCEC	chr17	31261751	Missense_Mutation	novel	A1540T	0.06
UCEC	chr17	31265270	Missense_Mutation	rs185660700	T1589M	0.26
UCEC	chr17	31327839	Missense_Mutation	rs786202112	R1870Q	0.33
UCEC	chr17	31349235	Silent	rs369754180	S2435S	0.34
UCEC	chr17	31232103	Silent	NA	V1076V	0.36
UCEC	chr17	31260498	Silent	NA	Q1520Q	0.41
UCEC	chr17	31261772	Missense_Mutation	novel	G1547C	0.06
UCEC	chr17	31233145	Missense_Mutation	novel	M1214V	0.22
UCEC	chr17	31226650	Missense_Mutation	novel	M739I	0.36
UCEC	chr17	31374233	3'UTR	novel		0.36
UCEC	chr17	31223523	Missense_Mutation	rs587782592	R601W	0.14
UCEC	chr17	31375591	3'UTR	novel		0.28
UCEC	chr17	31249031	Missense_Mutation	NA	Q1341P	0.07
UCEC	chr17	31221931	Splice_Site	novel	X574_splice	0.09
UCEC	chr17	31330527	Intron	novel		0.17
UCEC	chr17	31265318	Missense_Mutation	novel	I1605T	0.28
UCEC	chr17	31375633	3'UTR	novel		0.38
UCEC	chr17	31225109	Missense_Mutation	NA	S620R	0.41
UCEC	chr17	31229594	Intron	novel		0.17
UCEC	chr17	31232710	Silent	NA	L1109L	0.33
UCEC	chr17	31233079	Nonsense_Mutation	NA	E1192*	0.38
UCEC	chr17	31350249	Missense_Mutation	NA	L2463R	0.42
UCEC	chr17	31374653	3'UTR	novel		0.5
UCEC	chr17	31375030	3'UTR	novel		0.6
UCEC	chr17	31334897	Missense_Mutation	NA	R1958C	0.28
UCEC	chr17	31181459	Silent	rs370184932	A208A	0.16
UCEC	chr17	31229587	Intron	novel		0.48
UCEC	chr17	31230308	Silent	NA	T1013T	0.36
UCEC	chr17	31325982	Silent	NA	F1666F	0.18
UCEC	chr17	31326202	In_Frame_Ins	novel	F1740delinsYQQI	0.13
UCEC	chr17	31356472	Frame_Shift_Ins	novel	D2545*	0.3
UCEC	chr17	31169943	Nonsense_Mutation	NA	E178*	0.31
UCEC	chr17	31250179	Intron	novel		0.38
UCEC	chr17	31326161	Missense_Mutation	NA	L1726R	0.29
UCEC	chr17	31169954	Silent	novel	Q181Q	0.19
UCEC	chr17	31200492	Missense_Mutation	novel	A320D	0.44
UCEC	chr17	31229118	Nonsense_Mutation	novel	Q835*	0.18
UCEC	chr17	31326004	Missense_Mutation	novel	V1674I	0.27
UCEC	chr17	31326189	Missense_Mutation	novel	E1735D	0.18
UCEC	chr17	31327650	Missense_Mutation	novel	G1807D	0.21
UCEC	chr17	31327739	Missense_Mutation	rs771597781	D1837N	0.26
UCEC	chr17	31330305	Silent	novel	A1873A	0.44
UCEC	chr17	31330652	Intron	novel		0.19
UCEC	chr17	31349235	Silent	rs369754180	S2435S	0.22
UCEC	chr17	31352369	Missense_Mutation	novel	L2524M	0.22
UCEC	chr17	31356540	Missense_Mutation	novel	P2566S	0.33
UCEC	chr17	31360529	Missense_Mutation	NA	L2735I	0.2
UCEC	chr17	31230303	Missense_Mutation	novel	K1012Q	0.3
UCEC	chr17	31259074	Nonsense_Mutation	NA	E1459*	0.55
UCEC	chr17	31350209	Nonsense_Mutation	rs786202457	R2450*	0.29
UCEC	chr17	31350296	Missense_Mutation	novel	H2479N	0.44
UCEC	chr17	31374653	3'UTR	novel		0.56
UCEC	chr17	31206360	Nonsense_Mutation	NA	R461*	0.3
UCEC	chr17	31214494	Frame_Shift_Del	novel	*K480Nfs18**	0.3
UCEC	chr17	31229672	Intron	novel		0.36
UCEC	chr17	31336703	Silent	NA	H2072H	0.25
UCEC	chr17	31343025	Missense_Mutation	NA	F2360C	0.33
UCEC	chr17	31229956	Missense_Mutation	NA	M991K	0.33
UCEC	chr17	31327597	Silent	NA	E1789E	0.39
UCEC	chr17	31330462	Frame_Shift_Del	novel	*L1927Wfs15**	0.27
UCEC	chr17	31182612	Nonsense_Mutation	novel	E279*	0.36
UCEC	chr17	31249093	Nonsense_Mutation	rs137854560	R1362*	0.35
UCEC	chr17	31334897	Missense_Mutation	NA	R1958C	0.48
UCEC	chr17	31349239	Missense_Mutation	novel	A2437T	0.35
UCEC	chr17	31375625	3'UTR	novel		0.35
UCEC	chr17	31375831	3'UTR	novel		0.46
UCEC	chr17	31156003	Silent	NA	Q27Q	0.43
UCEC	chr17	31200485	Missense_Mutation	novel	E318K	0.36
UCEC	chr17	31260441	Silent	rs577394398	D1501D	0.32
UCEC	chr17	31336668	Missense_Mutation	novel	T2061A	0.07
UCEC	chr17	31375258	3'UTR	novel		0.41
UCS	chr17	31201423	Nonsense_Mutation	NA	Q400*	0.78
UCS	chr17	31374030	Missense_Mutation	rs377393842	V2799I	0.1
UCS	chr17	31357031	Missense_Mutation	novel	L2604I	0.33
UCS	chr17	31360548	Missense_Mutation	novel	T2741R	0.1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0	0.18166
GBM	DEL	0.1161	6.0683e-06
LAML	DEL	0.0628	0.0003238
LUSC	DEL	0.1856	0.00099377
OV	DEL	0.8014	4.6744e-18
SARC	DEL	0.2529	1.7643e-10
THCA	DEL	0.002	0.221
UCEC	DEL	0.1837	7.1897e-08
UCS	DEL	0.3571	0.19877
UVM	DEL	0.0375	0.22482

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00067	Kaplan-Meier Survival Analysis
MESO	0.031	Kaplan-Meier Survival Analysis
SKCM	0.0016	Kaplan-Meier Survival Analysis
LAML	0.00027	Kaplan-Meier Survival Analysis
UCEC	0.037	Kaplan-Meier Survival Analysis
LGG	0.0011	Kaplan-Meier Survival Analysis
UVM	0.0065	Kaplan-Meier Survival Analysis
OV	0.045	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000196712 (Gene tree)
Gene ID: 4763
Gene Symbol: NF1
Alias: N
Full Name: neurofibromin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 374,244 bases
Position: chr17:31,007,873-31,382,116
Accession: 7765
RBP type: non-canonical RBP
Summary: This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29066822	Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study.	Sci Rep	2017 Oct 24	Sagata N	doi: 10.1038/s41598-017-14440-7.
21111075	Long-range DNA interactions are specifically altered by locked nucleic acid-targeting of a CTCF binding site.	Biochim Biophys Acta	2011 Jan	Ling JQ	doi: 10.1016/j.bbagrm.2010.11.004
10673359	Tumor antigen HuR binds specifically to one of five protein-binding segments in the 3'-untranslated region of the neurofibromin messenger RNA.	Biochem Biophys Res Commun	2000 Jan 27	Haeussler J	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000577967	NF1-218	5799	-	-	- (aa)	-	-
ENST00000584328	NF1-223	566	-	-	- (aa)	-	-
ENST00000493220	NF1-215	5691	-	-	- (aa)	-	-
ENST00000358273	NF1-202	12425	-	ENSP00000351015	2839 (aa)	-	P21359
ENST00000431387	NF1-204	2889	-	ENSP00000412921	593 (aa)	-	P21359
ENST00000495910	NF1-216	8223	-	ENSP00000463682	124 (aa)	-	J3QLS2
ENST00000479614	NF1-210	1114	-	ENSP00000462157	206 (aa)	-	J3KRT8
ENST00000456735	NF1-205	7787	-	ENSP00000389907	2502 (aa)	-	H0Y465
ENST00000498569	NF1-217	620	-	-	- (aa)	-	-
ENST00000579081	NF1-219	8788	-	ENSP00000462408	1656 (aa)	-	J3KSB5
ENST00000479536	NF1-209	811	-	ENSP00000467080	81 (aa)	-	K7ENT2
ENST00000489712	NF1-213	543	-	-	- (aa)	-	-
ENST00000581113	NF1-220	1464	-	ENSP00000492721	237 (aa)	-	A0A1W2PS74
ENST00000487476	NF1-211	2265	-	ENSP00000491589	551 (aa)	-	P21359
ENST00000490416	NF1-214	1329	-	ENSP00000491431	233 (aa)	-	A0A1W2PPA7
ENST00000581790	NF1-221	1256	-	ENSP00000462700	206 (aa)	-	J3KSX8
ENST00000356175	NF1-201	12362	-	ENSP00000348498	2818 (aa)	-	P21359
ENST00000468273	NF1-207	592	-	ENSP00000464702	115 (aa)	-	K7EID4
ENST00000471572	NF1-208	2028	-	ENSP00000464678	640 (aa)	-	J3QSG6
ENST00000466819	NF1-206	1177	-	ENSP00000463819	227 (aa)	-	J3QQN8
ENST00000582892	NF1-222	462	-	-	- (aa)	-	-
ENST00000422121	NF1-203	619	-	ENSP00000465138	13 (aa)	-	K7EJE7
ENST00000488981	NF1-212	331	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000196712's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa01521	EGFR tyrosine kinase inhibitor resistance	KEGG
hsa04010	MAPK signaling pathway	KEGG
hsa04014	Ras signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000196712	Blood Pressure	6.7960000E-005	-
ENSG00000196712	Child Development Disorders, Pervasive	4.1000000E-005	-
ENSG00000196712	Child Development Disorders, Pervasive	1.5000000E-005	-
ENSG00000196712	Hip	2E-8	25673412

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000196712	rs3087591	17	31303952	A	Hip circumference	25673412	[0.014-0.029] unit decrease	0.0212	EFO_0005093
ENSG00000196712	rs17884466	17	31219747	A	Feeling nervous	29500382	z score decrease	5.56	EFO_0009597
ENSG00000196712	rs188460661	17	31366922	A	Familial squamous cell lung carcinoma	29924316	[2.50-8.59]	4.63	EFO_0000708\|EFO_0006953
ENSG00000196712	rs148176174	17	31219525	T	Familial squamous cell lung carcinoma	29924316	[2.48-8.52]	4.6	EFO_0000708\|EFO_0006953
ENSG00000196712	rs1129506	17	31319014	G	Endometrial cancer	30093612	[1.06-1.13]	1.1	EFO_1001512
ENSG00000196712	rs1129506	17	31319014	G	Endometrial cancer (endometrioid histology)	30093612	[1.07-1.15]	1.11	EFO_1001512
ENSG00000196712	rs150700179	17	31282303	G	Diverticular disease	30177863	[NR] unit increase	0.374	EFO_1001460
ENSG00000196712	rs2854322	17	31372398	T	Low density lipoprotein cholesterol levels	29507422	unit increase	0.017	EFO_0004611
ENSG00000196712	rs2854322	17	31372398	T	Total cholesterol levels	29507422	unit increase	0.02	EFO_0004574
ENSG00000196712	rs2905804	17	31192977	T	Adventurousness	30643258	[0.015-0.023] unit decrease	0.019181518	EFO_0008579
ENSG00000196712	rs2854322	17	31372398	?	Lipid traits (pleiotropy) (HIPO component 2)	30289880			EFO_0004574\|EFO_0004530\|EFO_0004611\|EFO_0004612
ENSG00000196712	rs2525565	17	31339570	C	Alcohol consumption (drinks per week) (MTAG)	30643251	[0.0062-0.0115] unit increase	0.00885905	EFO_0007878
ENSG00000196712	rs72815624	17	31289498	T	General risk tolerance (MTAG)	30643258	[0.012-0.019] unit decrease	0.0158	EFO_0008579
ENSG00000196712	rs2953013	17	31169325	C	Osteoarthritis of the hip or knee	30664745	[1.04-1.07]	1.05	EFO_1000786\|EFO_0004616

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196712's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	ISS	Process
GO:0000165	MAPK cascade	-	TAS	Process
GO:0001649	osteoblast differentiation	-	ISS	Process
GO:0001656	metanephros development	-	ISS	Process
GO:0001666	response to hypoxia	-	ISS	Process
GO:0001889	liver development	-	ISS	Process
GO:0001937	negative regulation of endothelial cell proliferation	16648142.17404841.	IMP	Process
GO:0001938	positive regulation of endothelial cell proliferation	-	IEA	Process
GO:0001952	regulation of cell-matrix adhesion	-	ISS	Process
GO:0001953	negative regulation of cell-matrix adhesion	-	IEA	Process
GO:0005096	GTPase activator activity	1568247.1570015.2121371.	IDA	Function
GO:0005515	protein binding	11356864.16374483.23027611.	IPI	Function
GO:0005634	nucleus	1550670.	ISS	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	1550670.	ISS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006469	negative regulation of protein kinase activity	-	ISS	Process
GO:0007154	cell communication	-	ISS	Process
GO:0007265	Ras protein signal transduction	-	ISS	Process
GO:0007406	negative regulation of neuroblast proliferation	-	ISS	Process
GO:0007420	brain development	-	ISS	Process
GO:0007422	peripheral nervous system development	-	ISS	Process
GO:0007507	heart development	-	ISS	Process
GO:0007519	skeletal muscle tissue development	-	IEA	Process
GO:0008429	phosphatidylethanolamine binding	17187824.	IDA	Function
GO:0008542	visual learning	-	ISS	Process
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	-	IEA	Process
GO:0010468	regulation of gene expression	-	IEA	Process
GO:0014044	Schwann cell development	-	ISS	Process
GO:0014065	phosphatidylinositol 3-kinase signaling	-	ISS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016525	negative regulation of angiogenesis	-	IEA	Process
GO:0021510	spinal cord development	-	ISS	Process
GO:0021764	amygdala development	-	IEA	Process
GO:0021897	forebrain astrocyte development	-	ISS	Process
GO:0021915	neural tube development	-	IEA	Process
GO:0021987	cerebral cortex development	-	ISS	Process
GO:0022011	myelination in peripheral nervous system	-	ISS	Process
GO:0030036	actin cytoskeleton organization	-	ISS	Process
GO:0030198	extracellular matrix organization	-	ISS	Process
GO:0030199	collagen fibril organization	-	ISS	Process
GO:0030325	adrenal gland development	-	ISS	Process
GO:0030336	negative regulation of cell migration	16648142.	IMP	Process
GO:0030424	axon	1550670.	IDA	Component
GO:0030425	dendrite	1550670.	IDA	Component
GO:0031210	phosphatidylcholine binding	17187824.	IDA	Function
GO:0032228	regulation of synaptic transmission, GABAergic	-	IEA	Process
GO:0034605	cellular response to heat	-	IEA	Process
GO:0035021	negative regulation of Rac protein signal transduction	-	IEA	Process
GO:0042060	wound healing	-	ISS	Process
GO:0042308	negative regulation of protein import into nucleus	-	IEA	Process
GO:0043065	positive regulation of apoptotic process	-	ISS	Process
GO:0043087	regulation of GTPase activity	1570015.	IMP	Process
GO:0043407	negative regulation of MAP kinase activity	-	ISS	Process
GO:0043409	negative regulation of MAPK cascade	16648142.	IMP	Process
GO:0043409	negative regulation of MAPK cascade	-	ISS	Process
GO:0043473	pigmentation	-	ISS	Process
GO:0043525	positive regulation of neuron apoptotic process	-	ISS	Process
GO:0043535	regulation of blood vessel endothelial cell migration	17404841.	IMP	Process
GO:0043547	positive regulation of GTPase activity	2121371.	IDA	Process
GO:0043547	positive regulation of GTPase activity	16648142.	IMP	Process
GO:0043547	positive regulation of GTPase activity	-	ISS	Process
GO:0045124	regulation of bone resorption	-	ISS	Process
GO:0045671	negative regulation of osteoclast differentiation	-	IEA	Process
GO:0045685	regulation of glial cell differentiation	-	ISS	Process
GO:0045762	positive regulation of adenylate cyclase activity	-	ISS	Process
GO:0045765	regulation of angiogenesis	17404841.	IMP	Process
GO:0046929	negative regulation of neurotransmitter secretion	-	IEA	Process
GO:0048147	negative regulation of fibroblast proliferation	-	ISS	Process
GO:0048169	regulation of long-term neuronal synaptic plasticity	-	IEA	Process
GO:0048485	sympathetic nervous system development	-	ISS	Process
GO:0048593	camera-type eye morphogenesis	-	ISS	Process
GO:0048712	negative regulation of astrocyte differentiation	-	IEA	Process
GO:0048715	negative regulation of oligodendrocyte differentiation	-	ISS	Process
GO:0048745	smooth muscle tissue development	-	ISS	Process
GO:0048820	hair follicle maturation	-	IEA	Process
GO:0048844	artery morphogenesis	-	ISS	Process
GO:0048853	forebrain morphogenesis	-	ISS	Process
GO:0050890	cognition	17299016.	IMP	Process
GO:0061534	gamma-aminobutyric acid secretion, neurotransmission	-	IEA	Process
GO:0061535	glutamate secretion, neurotransmission	-	IEA	Process
GO:0098597	observational learning	-	IEA	Process
GO:0098793	presynapse	-	IEA	Component
GO:1900271	regulation of long-term synaptic potentiation	-	IEA	Process
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	IEA	Process
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.