EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr5	177489509	Silent	novel	T251T	0.5
BLCA	chr5	177483876	Silent	rs143980931	F426F	0.54
BLCA	chr5	177483712	Missense_Mutation	NA	E436Q	0.17
BRCA	chr5	177483944	Missense_Mutation	NA	D404H	0.2
BRCA	chr5	177496432	Silent	NA	P27P	0.38
BRCA	chr5	177483977	Missense_Mutation	NA	E393Q	0.31
BRCA	chr5	177490552	Intron	novel		0.28
CESC	chr5	177490331	Intron	novel		0.4
CESC	chr5	177488102	Missense_Mutation	novel	P339L	0.3
CESC	chr5	177490892	Missense_Mutation	NA	E184K	0.49
CESC	chr5	177491016	Missense_Mutation	rs376862538	E177K	0.47
COAD	chr5	177483960	Silent	rs775765511	T398T	0.32
COAD	chr5	177488057	Intron	novel		0.3
COAD	chr5	177483961	Missense_Mutation	rs550156356	T398M	0.39
COAD	chr5	177483575	3'UTR	novel		0.36
COAD	chr5	177491895	Missense_Mutation	NA	Y104N	0.44
COAD	chr5	177491076	Missense_Mutation	NA	P157S	0.08
COAD	chr5	177496455	Missense_Mutation	NA	G20W	0.29
COAD	chr5	177488144	Missense_Mutation	NA	G325V	0.2
COAD	chr5	177488209	Silent	NA	P303P	0.24
COAD	chr5	177492420	Silent	NA	Q88Q	0.2
COAD	chr5	177483621	3'UTR	rs370965318		0.33
COAD	chr5	177490500	Intron	rs779665497		0.22
COAD	chr5	177496463	Missense_Mutation	NA	R17Q	0.23
COAD	chr5	177483876	Silent	rs143980931	F426F	0.28
COAD	chr5	177483960	Silent	rs775765511	T398T	0.13
COAD	chr5	177484072	Missense_Mutation	rs535394998	R390Q	0.48
COAD	chr5	177489886	Intron	NA		0.23
ESCA	chr5	177483723	Missense_Mutation	novel	Q432P	0.83
ESCA	chr5	177491058	Nonsense_Mutation	rs748660598	Q163*	0.19
GBM	chr5	177483615	3'UTR	novel		0.53
HNSC	chr5	177489444	Frame_Shift_Del	NA	*G273Afs84**	0.3
HNSC	chr5	177487978	Intron	novel		0.3
HNSC	chr5	177483983	Splice_Site	novel	X391_splice	0.1
KIRC	chr5	177490544	Intron	novel		0.27
LGG	chr5	177491074	Silent	rs145886743	P157P	0.35
LIHC	chr5	177490398	Intron	novel		0.67
LIHC	chr5	177483710	Silent	novel	E436E	0.03
LIHC	chr5	177489600	Missense_Mutation	NA	R221H	0.34
LUAD	chr5	177491101	Silent	novel	L148L	0.08
LUAD	chr5	177496489	Silent	NA	L8L	0.42
LUAD	chr5	177492547	Missense_Mutation	novel	R76L	0.23
LUAD	chr5	177489489	Missense_Mutation	novel	R258L	0.21
LUAD	chr5	177488217	Missense_Mutation	NA	Y301N	0.58
LUSC	chr5	177489533	Silent	novel	L243L	0.44
LUSC	chr5	177484112	Silent	NA	R377R	0.59
LUSC	chr5	177492523	Splice_Region	novel		0.66
MESO	chr5	177491878	Missense_Mutation	novel	S109R	0.16
OV	chr5	177484189	Missense_Mutation	novel	E351G	0.13
OV	chr5	177488180	Missense_Mutation	novel	K313R	0.38
OV	chr5	177484117	Missense_Mutation	novel	R375Q	0.43
OV	chr5	177488056	Intron	novel		0.18
OV	chr5	177488091	Missense_Mutation	novel	K343Q	0.33
OV	chr5	177489809	Missense_Mutation	NA	P199R	0.2
PRAD	chr5	177484073	Nonsense_Mutation	novel	R390*	0.34
READ	chr5	177483960	Silent	rs775765511	T398T	0.23
SKCM	chr5	177483915	Silent	novel	F413F	0.26
SKCM	chr5	177484119	Silent	novel	I374I	0.34
SKCM	chr5	177487980	Intron	novel		0.39
SKCM	chr5	177487998	Intron	novel		0.73
STAD	chr5	177490891	Missense_Mutation	NA	E184A	0.22
STAD	chr5	177492647	Missense_Mutation	rs753547502	G43R	0.33
STAD	chr5	177492611	Missense_Mutation	novel	G55S	0.7
STAD	chr5	177484089	Silent	rs371472586	G384G	0.26
STAD	chr5	177492638	Missense_Mutation	NA	V46M	0.44
STAD	chr5	177488117	Missense_Mutation	NA	D334G	0.41
STAD	chr5	177484089	Silent	rs371472586	G384G	0.34
STAD	chr5	177489470	Silent	novel	A264A	0.58
UCEC	chr5	177490390	Intron	novel		0.29
UCEC	chr5	177484178	Missense_Mutation	NA	A355T	0.5
UCEC	chr5	177490480	Intron	rs756990717		0.36
UCEC	chr5	177491035	Silent	novel	L170L	0.27
UCEC	chr5	177490303	Intron	novel		0.4
UCEC	chr5	177488111	Missense_Mutation	rs776416794	R336H	0.33
UCEC	chr5	177488068	Splice_Region	rs145315539	G350G	0.14
UCEC	chr5	177483890	Missense_Mutation	NA	H422Y	0.47
UCEC	chr5	177491092	Silent	novel	N151N	0.45
UCEC	chr5	177483897	Silent	rs757905078	F419F	0.21
UCEC	chr5	177490454	Intron	novel		0.1
UCEC	chr5	177490501	Intron	rs746536110		0.44
UCEC	chr5	177483728	Splice_Region	novel	I430I	0.33
UCEC	chr5	177483905	Missense_Mutation	novel	L417M	0.45
UCEC	chr5	177490868	Splice_Site	NA	X191_splice	0.36
UCEC	chr5	177490890	Missense_Mutation	novel	E184D	0.43
UCEC	chr5	177490394	Intron	novel		0.17
UCEC	chr5	177492582	Silent	rs755797490	I64I	0.11
UCEC	chr5	177490878	Missense_Mutation	novel	K188N	0.2
UCEC	chr5	177488112	Missense_Mutation	rs201493898	R336C	0.28
UCEC	chr5	177483611	3'UTR	novel		0.33
UCEC	chr5	177490395	Intron	novel		0.28
UCEC	chr5	177483876	Silent	rs143980931	F426F	0.32
UCEC	chr5	177488111	Missense_Mutation	rs776416794	R336H	0.49
UCEC	chr5	177484136	Missense_Mutation	novel	A369T	0.19

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.5909	2.1944e-60
KIRP	AMP	0.1111	0.069756
KIRP	DEL	0.0382	0.11554
LUAD	AMP	0.1744	0.24967
LUSC	DEL	0.5928	0.002071
MESO	DEL	0.1149	0.20184
PRAD	AMP	0.0305	0.16448
SKCM	AMP	0.1199	0.23703
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00012	Kaplan-Meier Survival Analysis
STAD	0.015	Kaplan-Meier Survival Analysis
SARC	0.0071	Kaplan-Meier Survival Analysis
MESO	0.00019	Kaplan-Meier Survival Analysis
ACC	0.00021	Kaplan-Meier Survival Analysis
UCS	0.014	Kaplan-Meier Survival Analysis
HNSC	0.021	Kaplan-Meier Survival Analysis
SKCM	0.0057	Kaplan-Meier Survival Analysis
LUSC	0.038	Kaplan-Meier Survival Analysis
ESCA	0.0083	Kaplan-Meier Survival Analysis
KIRP	0.00014	Kaplan-Meier Survival Analysis
COAD	0.0098	Kaplan-Meier Survival Analysis
BLCA	0.042	Kaplan-Meier Survival Analysis
LAML	0.0001	Kaplan-Meier Survival Analysis
UCEC	0.0011	Kaplan-Meier Survival Analysis
LIHC	0.015	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0047	Kaplan-Meier Survival Analysis
UVM	0.0093	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000196923 (Gene tree)
Gene ID: 9260
Gene Symbol: PDLIM7
Alias: ENIGMA
Full Name: PDZ and LIM domain 7
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 14,226 bases
Position: chr5:177,483,394-177,497,619
Accession: 22958
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31026779	Deciphering the three-domain architecture in schlafens and the structures and roles of human schlafen12 and serpinB12 in transcriptional regulation.	J Mol Graph Model	2019 Jul	Chen J	doi: 10.1016/j.jmgm.2019.04.003
11689659	Functional cooperation of Epstein-Barr virus nuclear antigen 2 and the survival motor neuron protein in transactivation of the viral LMP1 promoter.	J Virol	2001 Dec	Voss MD	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000503346	PDLIM7-209	669	-	-	- (aa)	-	-
ENST00000355572	PDLIM7-201	977	-	ENSP00000347776	222 (aa)	-	Q9NR12
ENST00000505074	PDLIM7-213	931	-	ENSP00000426213	287 (aa)	-	D6RH06
ENST00000503827	PDLIM7-210	451	-	ENSP00000422363	120 (aa)	-	H0Y8W6
ENST00000506537	PDLIM7-216	636	-	ENSP00000421664	90 (aa)	-	D6RAN1
ENST00000486828	PDLIM7-207	1904	-	ENSP00000439157	191 (aa)	-	Q9NR12
ENST00000504318	PDLIM7-211	597	-	-	- (aa)	-	-
ENST00000393551	PDLIM7-205	1226	-	ENSP00000377182	287 (aa)	-	Q9NR12
ENST00000463411	PDLIM7-206	1015	-	-	- (aa)	-	-
ENST00000504380	PDLIM7-212	556	-	-	- (aa)	-	-
ENST00000393546	PDLIM7-204	671	-	ENSP00000377177	195 (aa)	-	H7BYK4
ENST00000506161	PDLIM7-215	759	-	ENSP00000424850	173 (aa)	-	D6RF83
ENST00000493815	PDLIM7-208	1686	-	ENSP00000431236	153 (aa)	-	Q9NR12
ENST00000359895	PDLIM7-203	1567	-	ENSP00000352964	423 (aa)	-	Q9NR12
ENST00000355841	PDLIM7-202	1689	XM_011534698	ENSP00000348099	457 (aa)	XP_011533000	Q9NR12
ENST00000505746	PDLIM7-214	405	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000196923's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196923's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001503	ossification	-	IEA	Process
GO:0001725	stress fiber	-	IEA	Component
GO:0001726	ruffle	-	IEA	Component
GO:0005515	protein binding	16189514.16713569.23088713.25036637.25416956.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005913	cell-cell adherens junction	25468996.	IDA	Component
GO:0005925	focal adhesion	-	IDA	Component
GO:0006898	receptor-mediated endocytosis	7929196.	TAS	Process
GO:0007411	axon guidance	-	TAS	Process
GO:0015629	actin cytoskeleton	-	IDA	Component
GO:0030036	actin cytoskeleton organization	-	IEA	Process
GO:0045669	positive regulation of osteoblast differentiation	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.