EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27100483	The role of annexin A4 in cancer.	Front Biosci (Landmark Ed)	2016 Jun 1	Yao H	-
27491820	Annexin A4-nuclear factor-??B feedback circuit regulates cell malignant behavior and tumor growth in gallbladder cancer.	Sci Rep	2016 Aug 5	Yao HS	doi: 10.1038/srep31056.
30066907	Lewis(y) antigen-mediated positive feedback loop induces and promotes chemotherapeutic resistance in ovarian cancer.	Int J Oncol	2018 Oct	Liu J	doi: 10.3892/ijo.2018.4496
24223161	Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.	PLoS One	2013 Nov 6	Gaudio E	doi: 10.1371/journal.pone.0078610
26048190	Annexin A4 and cancer.	Clin Chim Acta	2015 Jul 20	Wei B	doi: 10.1016/j.cca.2015.05.016
27650619	The Role of Annexin A4 in Triple-Negative Breast Cancer Progression and Its Clinical Application.	Ann Clin Lab Sci	2016 Sep	Zhang ZG	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	69781552	5'UTR	novel		0.24
BLCA	chr2	69788074	Silent	novel	V10V	0.07
BLCA	chr2	69781552	5'UTR	novel		0.49
BLCA	chr2	69810651	Missense_Mutation	rs144937233	R152Q	0.13
BLCA	chr2	69781547	5'UTR	novel		0.29
BRCA	chr2	69806495	Missense_Mutation	NA	M101I	0.2
BRCA	chr2	69820765	Missense_Mutation	NA	D284N	0.38
BRCA	chr2	69788052	Splice_Site	novel	X4_splice	0.22
BRCA	chr2	69806397	Missense_Mutation	NA	D69N	0.13
CESC	chr2	69807979	Missense_Mutation	novel	S127N	0.56
COAD	chr2	69818625	Missense_Mutation	NA	Q219E	0.37
COAD	chr2	69818650	Missense_Mutation	novel	K227T	0.23
COAD	chr2	69825559	3'UTR	rs767314528		0.2
COAD	chr2	69804547	Missense_Mutation	rs376382183	A38T	0.38
COAD	chr2	69820742	Missense_Mutation	NA	S276F	0.2
COAD	chr2	69810853	Intron	novel		0.35
COAD	chr2	69810674	Splice_Site	NA	X159_splice	0.12
ESCA	chr2	69806409	Missense_Mutation	novel	E73K	0.36
ESCA	chr2	69806447	Missense_Mutation	novel	M85I	0.09
ESCA	chr2	69826257	3'UTR	novel		0.4
GBM	chr2	69819301	Missense_Mutation	novel	S249Y	0.29
GBM	chr2	69810653	Missense_Mutation	novel	V153L	0.08
HNSC	chr2	69820816	Missense_Mutation	novel	I301F	0.59
HNSC	chr2	69788101	Frame_Shift_Del	novel	*E20Kfs6**	0.28
KIRC	chr2	69818604	Missense_Mutation	NA	D212N	0.22
KIRP	chr2	69812672	Missense_Mutation	NA	N166I	0.36
LIHC	chr2	69788070	Missense_Mutation	NA	T9I	0.11
LUAD	chr2	69825495	Missense_Mutation	novel	L316V	0.16
LUAD	chr2	69820698	Splice_Site	rs4493288	X262_splice	0.12
LUAD	chr2	69816132	Missense_Mutation	novel	G189E	0.09
LUSC	chr2	69810720	Intron	novel		0.3
LUSC	chr2	69825480	Missense_Mutation	novel	K311E	0.13
LUSC	chr2	69788141	Missense_Mutation	NA	G33C	0.31
LUSC	chr2	69816129	Missense_Mutation	novel	W188L	0.29
OV	chr2	69788080	Silent	novel	A12A	0.06
OV	chr2	69788065	Silent	novel	G7G	0.08
PRAD	chr2	69818602	Missense_Mutation	NA	F211C	0.08
PRAD	chr2	69820750	Nonsense_Mutation	novel	E279*	0.49
READ	chr2	69825740	3'UTR	novel		0.27
SARC	chr2	69816192	Missense_Mutation	novel	H209L	0.27
SKCM	chr2	69810623	Missense_Mutation	rs755577388	R143C	0.44
SKCM	chr2	69810623	Missense_Mutation	rs755577388	R143C	0.11
SKCM	chr2	69825510	Missense_Mutation	NA	D321N	0.5
STAD	chr2	69806440	Missense_Mutation	NA	V83E	0.17
STAD	chr2	69806488	Missense_Mutation	novel	R99M	0.1
STAD	chr2	69812691	Silent	rs141776547	L172L	0.34
STAD	chr2	69804547	Missense_Mutation	rs376382183	A38T	0.34
STAD	chr2	69806396	Silent	rs148077345	D68D	0.44
STAD	chr2	69788128	Silent	NA	A28A	0.3
STAD	chr2	69810603	Missense_Mutation	NA	R136L	0.39
THYM	chr2	69781516	Splice_Region	novel		0.28
UCEC	chr2	69810829	Intron	novel		0.43
UCEC	chr2	69826328	3'UTR	novel		0.36
UCEC	chr2	69825501	Missense_Mutation	novel	G318R	0.17
UCEC	chr2	69816152	Missense_Mutation	novel	L196I	0.08
UCEC	chr2	69825617	3'UTR	novel		0.39
UCEC	chr2	69826257	3'UTR	novel		0.29
UCEC	chr2	69804537	Silent	rs151130421	T34T	0.12
UCEC	chr2	69788140	Splice_Region	rs187492712	L32L	0.48
UCEC	chr2	69806427	Missense_Mutation	NA	E79K	0.42
UCEC	chr2	69806453	Silent	novel	T87T	0.37
UCEC	chr2	69804587	Missense_Mutation	rs761374777	R51H	0.34
UCEC	chr2	69826015	3'UTR	novel		0.57
UCEC	chr2	69816177	Missense_Mutation	rs373624358	R204Q	0.32
UCEC	chr2	69812651	Splice_Site	novel	X160_splice	0.32
UCEC	chr2	69788063	Nonsense_Mutation	NA	G7*	0.2
UCEC	chr2	69820811	Missense_Mutation	rs765123505	S299L	0.26
UCEC	chr2	69804538	Missense_Mutation	NA	D35N	0.38
UCEC	chr2	69810829	Intron	novel		0.5
UCEC	chr2	69826274	3'UTR	novel		0.5
UCEC	chr2	69820787	Missense_Mutation	novel	R291K	0.1
UCEC	chr2	69807959	Silent	novel	P120P	0.19
UCEC	chr2	69810877	Intron	novel		0.46
UCEC	chr2	69806453	Silent	novel	T87T	0.44
UCEC	chr2	69819331	Missense_Mutation	rs140302494	S259L	0.55
UCEC	chr2	69825545	3'UTR	novel		0.35
UCEC	chr2	69826385	3'UTR	novel		0.23
UCEC	chr2	69826148	3'UTR	novel		0.2
UCEC	chr2	69781518	Splice_Site	NA		0.49
UCEC	chr2	69826262	3'UTR	novel		0.3
UCEC	chr2	69810803	Intron	novel		0.24
UCEC	chr2	69804621	Silent	rs766437171	I62I	0.33
UCEC	chr2	69826090	3'UTR	novel		0.24
UCEC	chr2	69807952	Missense_Mutation	rs144504684	R118Q	0.41
UCEC	chr2	69819331	Missense_Mutation	rs140302494	S259L	0.38
UCEC	chr2	69820732	Missense_Mutation	novel	V273M	0.37
UCEC	chr2	69807990	Nonsense_Mutation	novel	Q131*	0.25
UCEC	chr2	69826357	3'UTR	novel		0.41
UCEC	chr2	69807913	Missense_Mutation	rs778785400	G105D	0.46
UCEC	chr2	69826257	3'UTR	novel		0.48
UCEC	chr2	69788137	Silent	NA	G31G	0.53
UCEC	chr2	69807996	Nonsense_Mutation	rs774777486	Q133*	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0489	0.2014
READ	DEL	0.0667	0.19022

Survival Analysis

Cancer	P-value	Q-value
THYM	0.018	Kaplan-Meier Survival Analysis
KIRC	0.0057	Kaplan-Meier Survival Analysis
ACC	0.044	Kaplan-Meier Survival Analysis
KIRP	0.00039	Kaplan-Meier Survival Analysis
PAAD	0.032	Kaplan-Meier Survival Analysis
LAML	0.0079	Kaplan-Meier Survival Analysis
KICH	0.043	Kaplan-Meier Survival Analysis
GBM	0.0036	Kaplan-Meier Survival Analysis
LGG	0.0003	Kaplan-Meier Survival Analysis
CHOL	0.034	Kaplan-Meier Survival Analysis
UVM	0.0004	Kaplan-Meier Survival Analysis
OV	0.0011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000196975 (Gene tree)
Gene ID: 307
Gene Symbol: ANXA4
Alias: ANX4
Full Name: annexin A4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 183,001 bases
Position: chr2:69,644,100-69,827,100
Accession: 542
RBP type: non-canonical RBP
Summary: Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409920	ANXA4-202	1414	-	ENSP00000386756	299 (aa)	-	Q6P452
ENST00000477632	ANXA4-209	3949	-	-	- (aa)	-	-
ENST00000418066	ANXA4-203	905	-	-	- (aa)	-	-
ENST00000471395	ANXA4-207	4418	-	-	- (aa)	-	-
ENST00000394295	ANXA4-201	2799	XM_017003943	ENSP00000377833	321 (aa)	XP_016859432	P09525
ENST00000460439	ANXA4-204	543	-	-	- (aa)	-	-
ENST00000468815	ANXA4-206	521	-	ENSP00000489490	8 (aa)	-	A0A0U1RRE7
ENST00000487351	ANXA4-211	552	-	-	- (aa)	-	-
ENST00000472124	ANXA4-208	376	-	ENSP00000489464	7 (aa)	-	A0A1Y8EKW3
ENST00000460942	ANXA4-205	576	-	-	- (aa)	-	-
ENST00000635311	ANXA4-212	1492	-	ENSP00000489316	142 (aa)	-	B4E1S2
ENST00000484219	ANXA4-210	338	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000196975's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000196975	Carcinoma, Non-Small-Cell Lung	5.3940000E-005	-
ENSG00000196975	Carcinoma, Non-Small-Cell Lung	6.2340000E-005	-
ENSG00000196975	Phospholipids	5E-6	23362303

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000196975	rs7597155	2	69758303	A	Palmitoleic acid (16:1n-7) levels	23362303	unit increase	0.0149	EFO_0005110
ENSG00000196975	rs62133983	2	69749252	G	Atrial fibrillation	28416818	[1.06-1.12]	1.09	EFO_0000275
ENSG00000196975	rs6546550	2	69811100	C	Prevalent atrial fibrillation	28416818	1.08-1.16	1.12	EFO_0000275

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196975's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004859	phospholipase inhibitor activity	2970257.	NAS	Function
GO:0005509	calcium ion binding	21873635.	IBA	Function
GO:0005509	calcium ion binding	20237821.	IDA	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	21044950.	IPI	Function
GO:0005544	calcium-dependent phospholipid binding	2138016.	IDA	Function
GO:0005544	calcium-dependent phospholipid binding	2970257.	NAS	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	16687573.20237821.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	20237821.	IDA	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	16687573.	IDA	Component
GO:0006357	regulation of transcription by RNA polymerase II	20237821.	IDA	Process
GO:0007165	signal transduction	16130169.	TAS	Process
GO:0007219	Notch signaling pathway	21873635.	IBA	Process
GO:0008201	heparin binding	21873635.	IBA	Function
GO:0009986	cell surface	22056994.	IDA	Component
GO:0012506	vesicle membrane	16687573.	IDA	Component
GO:0030855	epithelial cell differentiation	21873635.	IBA	Process
GO:0030855	epithelial cell differentiation	21492153.	IEP	Process
GO:0031965	nuclear membrane	16687573.	IDA	Component
GO:0032088	negative regulation of NF-kappaB transcription factor activity	20237821.	IDA	Process
GO:0035374	chondroitin sulfate binding	21873635.	IBA	Function
GO:0042802	identical protein binding	21873635.	IBA	Function
GO:0042802	identical protein binding	16687573.	IPI	Function
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0043086	negative regulation of catalytic activity	-	IEA	Process
GO:0048306	calcium-dependent protein binding	21873635.	IBA	Function
GO:0048306	calcium-dependent protein binding	15226301.20237821.	IPI	Function
GO:0048471	perinuclear region of cytoplasm	16687573.	IDA	Component
GO:0051059	NF-kappaB binding	20237821.	IPI	Function
GO:0062023	collagen-containing extracellular matrix	25037231.28675934.	HDA	Component
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:2000483	negative regulation of interleukin-8 secretion	22056994.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.