EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27701147Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness.J Clin Invest2016 Nov 1Leca Jdoi: 10.1172/JCI87734
24354805Reduced annexin A6 expression promotes the degradation of activated epidermal growth factor receptor and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors.Mol Cancer2013 Dec 19Koumangoye RBdoi: 10.1186/1476-4598-12-167.
21185831Annexin A6 contributes to the invasiveness of breast carcinoma cells by influencing the organization and localization of functional focal adhesions.Exp Cell Res2011 Apr 1Sakwe AMdoi: 10.1016/j.yexcr.2010.12.008

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr5151136300Frame_Shift_DelnovelD149Tfs*230.47
BLCAchr5151103605Missense_MutationNAE643K0.29
BLCAchr5151132533Missense_MutationNAE227K0.26
BLCAchr5151136259SilentnovelL162L0.19
BLCAchr5151132543SilentnovelG223G0.31
BLCAchr5151133103Missense_MutationnovelL211V0.53
BLCAchr5151147897Missense_MutationnovelA2V0.2
BLCAchr5151147898Missense_MutationnovelA2S0.2
BRCAchr5151103646Missense_Mutationrs772576227R629H0.15
BRCAchr5151103654Missense_MutationNAM626I0.33
BRCAchr5151123003Missense_Mutationrs748009214E383K0.36
BRCAchr5151124307Missense_MutationnovelR373W0.04
BRCAchr5151129483Missense_Mutationrs763713710R281H0.1
BRCAchr51511014063'UTRnovel0.08
BRCAchr5151109787SilentnovelI550I0.09
BRCAchr5151129420Missense_MutationNAY302C0.24
CESCchr5151122958Missense_MutationnovelR398W0.42
CESCchr5151122936Frame_Shift_DelnovelF405Sfs*90.14
CESCchr5151139424Missense_MutationnovelD45N0.2
CESCchr5151137283SilentnovelL119L0.43
CHOLchr5151105278SilentnovelL602L0.37
COADchr5151129488SilentNAV279V0.36
COADchr5151123011Missense_MutationNAG380E0.22
COADchr5151122954Missense_MutationNAQ399R0.1
COADchr5151132538Missense_MutationNAP225Q0.21
COADchr5151136304Silentrs181203511I147I0.35
COADchr5151132485SilentNAL243L0.2
COADchr5151131248Missense_MutationNAL260I0.34
COADchr5151105276Missense_MutationNAF603Y0.13
COADchr5151110645Splice_SiteNAX525_splice0.05
COADchr5151122943Nonsense_MutationNAQ403*0.43
COADchr5151117758Splice_RegionNAT506T0.1
COADchr5151139409Missense_Mutationrs758088547R50W0.28
COADchr5151133118Missense_MutationNAR206C0.22
COADchr51511013363'UTRnovel0.38
COADchr5151105264Missense_MutationNAK607T0.34
COADchr51511479205'UTRnovel0.33
COADchr5151123003Missense_Mutationrs748009214E383K0.51
COADchr5151147900Translation_Start_SiteNAM1?0.24
COADchr5151139426Missense_MutationnovelL44Q0.05
COADchr5151117818Missense_MutationNAE486D0.31
COADchr51511014463'UTRnovel0.42
GBMchr5151119351Frame_Shift_DelnovelA463Pfs*270.12
GBMchr5151132528SilentNAA228A0.33
HNSCchr5151119383Missense_MutationnovelG452A0.07
HNSCchr5151132520Missense_Mutationrs370325414R231Q0.22
HNSCchr5151132520Missense_Mutationrs370325414R231Q0.35
HNSCchr5151117833Nonsense_MutationnovelY481*0.28
HNSCchr5151122979Missense_MutationnovelT391A0.22
KIRCchr5151140171Missense_MutationNAT31A0.25
KIRCchr5151105302Frame_Shift_InsnovelQ595Sfs*250.05
KIRCchr5151105303Frame_Shift_InsnovelV594Dfs*230.05
KIRCchr5151140230Missense_Mutationrs200516508R11Q0.14
LGGchr5151108548Missense_MutationnovelF563L0.38
LGGchr5151108493Missense_MutationnovelE581G0.42
LGGchr5151134454Silentrs752269503S173S0.4
LGGchr5151103605Frame_Shift_InsnovelE643Rfs*210.13
LGGchr5151103606SilentnovelI642I0.13
LIHCchr5151137257Missense_MutationnovelH128R0.38
LIHCchr5151103685Frame_Shift_DelnovelG616Afs*70.41
LUADchr5151122214Missense_MutationNAR427K0.18
LUADchr5151103661Missense_MutationNAR624T0.47
LUADchr5151122953Missense_MutationnovelQ399H0.15
LUADchr5151128201Missense_MutationnovelK319N0.61
LUADchr5151129498Missense_MutationnovelR276P0.43
LUADchr5151129448Missense_MutationnovelF293I0.26
LUADchr5151103589Missense_MutationNAS648F0.15
LUSCchr5151117181Splice_SiteNAX507_splice0.28
LUSCchr5151134483Missense_MutationNAG164R0.3
LUSCchr5151105266Missense_MutationNAD606E0.39
LUSCchr5151134483Missense_MutationNAG164R0.26
LUSCchr5151139365SilentNAS64S0.15
LUSCchr5151108479Missense_Mutationrs201027048V586I0.04
LUSCchr5151123012Splice_SiteNAX380_splice0.49
LUSCchr5151139371Nonsense_MutationnovelY62*0.14
OVchr5151122195Missense_MutationnovelM433I0.18
OVchr5151122196Frame_Shift_InsnovelM433Tfs*80.17
OVchr5151139420Frame_Shift_InsnovelI46Sfs*100.07
OVchr5151131283Missense_MutationnovelC248Y0.05
OVchr5151139368Silentrs369346632K63K0.19
PAADchr5151117825Missense_MutationnovelS484F0.2
PAADchr5151119347Missense_MutationNAT464I0.2
PRADchr5151124286Missense_MutationnovelG380W0.08
READchr5151105268Missense_Mutationrs771610573D606N0.34
READchr5151105290Missense_MutationNAK598N0.11
READchr5151110633Missense_MutationnovelE528D0.14
SARCchr5151108454Splice_SitenovelX594_splice0.17
SARCchr51511012683'UTRnovel0.5
SKCMchr5151109813Missense_MutationNAS542A0.11
SKCMchr5151108460Missense_MutationNAA592V0.37
SKCMchr5151108518Missense_Mutationrs368344684D573N0.25
SKCMchr5151139365SilentNAS64S0.19
SKCMchr5151132567Silentrs376092227F215F0.16
SKCMchr5151140223SilentnovelS13S0.08
SKCMchr5151140160SilentNAK34K0.23
SKCMchr5151105252Missense_MutationnovelS611F0.52
SKCMchr5151132529Missense_MutationNAA228V0.48
SKCMchr5151122939Missense_MutationNAT404I0.96
SKCMchr5151122238Missense_MutationnovelS419F0.26
STADchr5151147884Missense_MutationnovelQ6H0.25
STADchr5151122946Missense_Mutationrs762451507R402W0.15
STADchr5151136316Missense_MutationnovelE143D0.17
STADchr5151126414SilentNAV348V0.14
STADchr5151105267Missense_MutationNAD606G0.08
STADchr5151109766Silentrs751215230P557P0.27
STADchr5151129516Missense_Mutationrs374143469R270Q0.53
UCECchr5151105249Missense_Mutationrs753583716M612T0.43
UCECchr5151117758Splice_Regionrs377149334T506T0.49
UCECchr5151122973Missense_MutationNAR393C0.53
UCECchr5151117768Missense_MutationNAS503Y0.38
UCECchr5151128216Missense_MutationNAK314N0.31
UCECchr5151124312Missense_MutationnovelA371V0.38
UCECchr51511013053'UTRnovel0.44
UCECchr5151139409Missense_Mutationrs758088547R50W0.26
UCECchr5151140180Missense_MutationNAA28T0.2
UCECchr5151133154Missense_MutationNAT194A0.29
UCECchr5151124351Missense_Mutationrs545945295R358H0.4
UCECchr5151132537Silentrs373984263P225P0.46
UCECchr5151132567Silentrs376092227F215F0.32
UCECchr5151137286SilentnovelI118I0.29
UCECchr51511013523'UTRnovel0.41
UCECchr51511013363'UTRnovel0.69
UCECchr5151133178Missense_Mutationrs371950946E186K0.33
UCECchr5151133117Missense_Mutationrs759582371R206H0.56
UCECchr5151122231SilentnovelI421I0.43
UCECchr5151133128SilentNAI202I0.29
UCECchr5151101496Silentrs769574021S658S0.45
UCECchr5151124318Missense_MutationnovelA369V0.31
UCECchr5151109766Silentrs751215230P557P0.2
UCECchr5151132567Silentrs376092227F215F0.29
UCECchr5151101495Missense_Mutationrs747761940G659R0.46
UCECchr5151137238SilentnovelY134Y0.43
UCECchr5151136326Missense_Mutationrs781123987R140Q0.32
UCECchr5151101465Missense_MutationNAC669R0.41
UCECchr5151109797Missense_MutationnovelF547S0.18
UCECchr5151129456Missense_MutationnovelR290Q0.27
UCECchr5151105271Missense_MutationNAA605T0.23
UCECchr5151117780Missense_MutationNAR499K0.12
UCECchr5151136301Silentrs775504114G148G0.33
UCECchr5151132479Missense_Mutationrs199837151V245I0.06
UCECchr5151108511Missense_MutationnovelE575V0.05
UCECchr5151133139Frame_Shift_InsnovelF199Ifs*360.02
UCECchr5151133103Missense_MutationnovelL211I0.06
UCECchr51511479055'UTRnovel0.04
UCECchr5151117802Missense_MutationnovelD492Y0.2
UCECchr5151122176Missense_Mutationrs540689618D440N0.25
UCECchr5151108505Missense_MutationNAT577I0.24
UCECchr5151122983SilentnovelI389I0.29
UCECchr5151133118Missense_MutationNAR206C0.55
UCECchr5151139380SilentnovelC59C0.4
UCECchr5151124345Missense_MutationnovelA360V0.41
UCSchr5151132520Missense_Mutationrs370325414R231P0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPAMP0.10420.069756
KIRPDEL0.03820.11554
LAMLDEL0.08381.2971e-07
LUSCDEL0.62080.002071
MESODEL0.13790.20184
PRADAMP0.02440.16448
SKCMDEL0.2972.2081e-08
THCAAMP0.03610.075436
THCADEL00.23456

Survival Analysis
CancerP-value Q-value
MESO0.0078

Kaplan-Meier Survival Analysis

PRAD0.039

Kaplan-Meier Survival Analysis

LUSC0.04

Kaplan-Meier Survival Analysis

KIRP0.012

Kaplan-Meier Survival Analysis

PAAD0.0013

Kaplan-Meier Survival Analysis

BLCA0.00053

Kaplan-Meier Survival Analysis

LGG0.00049

Kaplan-Meier Survival Analysis

LUAD0.0098

Kaplan-Meier Survival Analysis

OV0.021

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000197043 (Gene tree)
Gene ID
309
Gene Symbol
ANXA6
Alias
ANX6
Full Name
annexin A6
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
57,177 bases
Position
chr5:151,100,706-151,157,882
Accession
544
RBP type
non-canonical RBP
Summary
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000522664ANXA6-213451-ENSP0000043108691 (aa)-H0YC77
ENST00000520054ANXA6-209487--- (aa)--
ENST00000521749ANXA6-212880-ENSP00000430429150 (aa)-E5RK63
ENST00000521512ANXA6-2111793-ENSP00000430420460 (aa)-E5RK69
ENST00000523714ANXA6-2152451-ENSP00000430517641 (aa)-P08133
ENST00000520378ANXA6-2101119--- (aa)--
ENST00000517677ANXA6-204795-ENSP00000430826129 (aa)-E5RI05
ENST00000523164ANXA6-214923-ENSP00000431078110 (aa)-E5RJR0
ENST00000517486ANXA6-203562-ENSP00000428916156 (aa)-E5RFF0
ENST00000517757ANXA6-206553-ENSP00000430572129 (aa)-E5RJF5
ENST00000354546ANXA6-2012593XM_005268432ENSP00000346550673 (aa)-P08133
ENST00000377751ANXA6-2021430-ENSP00000366980330 (aa)-E7EMC6
ENST00000519644ANXA6-208728-ENSP0000043066395 (aa)-E5RIU8
ENST00000517707ANXA6-205603--- (aa)--
ENST00000519610ANXA6-207899--- (aa)--
Gene Model
Click here to download ENSG00000197043's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000197043Platelet Function Tests1.4291000E-005-
ENSG00000197043Platelet Function Tests1.3802100E-005-
ENSG00000197043Platelet Function Tests1.2186200E-005-
ENSG00000197043Cryptoxanthins3.9490000E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000197043rs177285785151138507?Adolescent idiopathic scoliosis30019117EFO_0005423
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197043's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000197043ANXA610094.852ENSMUSG00000018340Anxa610094.354Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001755neural crest cell migration21873635.IBAProcess
GO:0001778plasma membrane repair21873635.IBAProcess
GO:0001786phosphatidylserine binding21873635.IBAFunction
GO:0003418growth plate cartilage chondrocyte differentiation21873635.IBAProcess
GO:0005262calcium channel activity21873635.IBAFunction
GO:0005509calcium ion binding-IEAFunction
GO:0005515protein binding15576473.IPIFunction
GO:0005525GTP binding21873635.IBAFunction
GO:0005525GTP binding16605264.IMPFunction
GO:0005544calcium-dependent phospholipid binding21873635.IBAFunction
GO:0005544calcium-dependent phospholipid binding2138016.IDAFunction
GO:0005739mitochondrion-IEAComponent
GO:0005765lysosomal membrane23360953.IDAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0005925focal adhesion21873635.IBAComponent
GO:0006937regulation of muscle contraction21873635.IBAProcess
GO:0008201heparin binding21873635.IBAFunction
GO:0008289lipid binding16605264.IMPFunction
GO:0015276ligand-gated ion channel activity21873635.IBAFunction
GO:0015276ligand-gated ion channel activity16605264.IMPFunction
GO:0015485cholesterol binding21873635.IBAFunction
GO:0015485cholesterol binding23360953.IDAFunction
GO:0016020membrane19946888.HDAComponent
GO:0019899enzyme binding21873635.IBAFunction
GO:0031214biomineral tissue development21873635.IBAProcess
GO:0031902late endosome membrane23360953.IDAComponent
GO:0034220ion transmembrane transport16605264.IMPProcess
GO:0035374chondroitin sulfate binding21873635.IBAFunction
GO:0038023signaling receptor activity21873635.IBAFunction
GO:0042470melanosome-IEAComponent
GO:0042803protein homodimerization activity21873635.IBAFunction
GO:0042803protein homodimerization activity16605264.IMPFunction
GO:0044877protein-containing complex binding21873635.IBAFunction
GO:0048306calcium-dependent protein binding21873635.IBAFunction
GO:0048306calcium-dependent protein binding15226301.IPIFunction
GO:0048471perinuclear region of cytoplasm-IEAComponent
GO:0051015actin filament binding21873635.IBAFunction
GO:0051260protein homooligomerization21873635.IBAProcess
GO:0051260protein homooligomerization16605264.IMPProcess
GO:0051283negative regulation of sequestering of calcium ion21873635.IBAProcess
GO:0051560mitochondrial calcium ion homeostasis21873635.IBAProcess
GO:0062023collagen-containing extracellular matrix25037231.28344315.28675934.HDAComponent
GO:0062023collagen-containing extracellular matrix28327460.HDAComponent
GO:0070062extracellular exosome19056867.20458337.21362503.23533145.HDAComponent
GO:0070509calcium ion import21873635.IBAProcess
GO:0070588calcium ion transmembrane transport-IEAProcess
GO:0097190apoptotic signaling pathway21873635.IBAProcess
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