EuRBPDB

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Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	26104117	Missense_Mutation	novel	G57V	0.17
BLCA	chr6	26103987	Missense_Mutation	novel	G14R	0.08
BLCA	chr6	26104095	Missense_Mutation	novel	L50V	0.8
BLCA	chr6	26104264	3'UTR	novel		0.62
BRCA	chr6	26104250	Silent	rs778556234	F101F	0.09
BRCA	chr6	26104016	Silent	novel	L23L	0.2
BRCA	chr6	26104007	Silent	novel	R20R	0.07
CESC	chr6	26104258	Silent	rs771490255	*104*	0.11
CESC	chr6	26104082	Missense_Mutation	NA	K45N	0.23
CESC	chr6	26103992	Silent	novel	G15G	0.6
CESC	chr6	26103978	Missense_Mutation	novel	L11M	0.09
COAD	chr6	26104139	Silent	rs750302109	E64E	0.33
COAD	chr6	26104157	Silent	rs758943077	A70A	0.26
ESCA	chr6	26104227	Missense_Mutation	novel	Q94E	0.16
ESCA	chr6	26104239	Silent	rs781429243	L98L	0.11
HNSC	chr6	26104282	3'UTR	novel		0.6
HNSC	chr6	26104150	Missense_Mutation	NA	R68P	0.26
HNSC	chr6	26103975	Missense_Mutation	novel	G10R	0.35
HNSC	chr6	26104150	Missense_Mutation	NA	R68P	0.18
KIRC	chr6	26103969	Missense_Mutation	novel	G8R	0.34
KIRP	chr6	26103977	Silent	rs139978722	G10G	0.22
LGG	chr6	26104099	Missense_Mutation	rs767447937	I51T	0.16
LIHC	chr6	26103996	Nonsense_Mutation	novel	K17*	0.25
LIHC	chr6	26104213	Missense_Mutation	NA	Y89C	0.2
LIHC	chr6	26104065	Missense_Mutation	novel	R40G	0.05
LIHC	chr6	26103971	Silent	rs763181691	G8G	0.12
LUAD	chr6	26104142	Missense_Mutation	novel	N65K	0.12
LUAD	chr6	26104046	Silent	novel	P33P	0.57
LUAD	chr6	26104295	3'UTR	novel		0.36
LUAD	chr6	26104017	Missense_Mutation	novel	R24W	0.17
LUAD	chr6	26103947	5'UTR	rs747940169		0.2
LUAD	chr6	26104020	Missense_Mutation	novel	D25N	0.1
LUAD	chr6	26104133	Silent	rs141888021	F62F	0.08
LUSC	chr6	26104032	Missense_Mutation	novel	G29C	0.1
LUSC	chr6	26104033	Missense_Mutation	rs752528297	G29D	0.09
LUSC	chr6	26104062	Missense_Mutation	NA	A39S	0.23
LUSC	chr6	26104189	Missense_Mutation	rs748976885	T81I	0.63
LUSC	chr6	26104072	Missense_Mutation	novel	G42V	0.29
LUSC	chr6	26103973	Frame_Shift_Del	novel	*L11Wfs3**	0.22
MESO	chr6	26104076	Silent	novel	G43G	0.4
OV	chr6	26104071	Missense_Mutation	NA	G42R	0.3
OV	chr6	26103958	Missense_Mutation	novel	R4L	0.06
READ	chr6	26104294	3'UTR	novel		0.31
READ	chr6	26103978	Silent	novel	L11L	0.31
SARC	chr6	26104150	Missense_Mutation	NA	R68P	0.19
SARC	chr6	26103965	Silent	novel	K6K	0.48
SKCM	chr6	26104090	Missense_Mutation	NA	S48F	0.28
SKCM	chr6	26104002	Missense_Mutation	NA	H19Y	0.15
SKCM	chr6	26104165	Missense_Mutation	novel	Y73C	0.3
SKCM	chr6	26103977	Silent	rs139978722	G10G	0.38
SKCM	chr6	26104113	Missense_Mutation	NA	R56G	0.25
SKCM	chr6	26104091	Silent	rs548111237	S48S	0.27
STAD	chr6	26104001	Silent	NA	R18R	0.31
STAD	chr6	26104289	3'UTR	novel		0.15
STAD	chr6	26104190	Frame_Shift_Del	rs747366650	*V82Hfs?**	0.2
UCEC	chr6	26104079	Silent	NA	V44V	0.51
UCEC	chr6	26104104	Missense_Mutation	novel	E53Q	0.17
UCEC	chr6	26104197	Missense_Mutation	novel	A84T	0.39
UCEC	chr6	26104300	3'UTR	novel		0.31
UCEC	chr6	26104300	3'UTR	novel		0.29
UCS	chr6	26104196	Silent	novel	T83T	0.2

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1186	0.046699

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0026	Kaplan-Meier Survival Analysis
KIRC	0.0008	Kaplan-Meier Survival Analysis
STAD	0.025	Kaplan-Meier Survival Analysis
SARC	0.0013	Kaplan-Meier Survival Analysis
ACC	0.021	Kaplan-Meier Survival Analysis
LUSC	0.0023	Kaplan-Meier Survival Analysis
ESCA	0.024	Kaplan-Meier Survival Analysis
PAAD	0.025	Kaplan-Meier Survival Analysis
BLCA	0.0058	Kaplan-Meier Survival Analysis
CESC	0.0013	Kaplan-Meier Survival Analysis
UCEC	0.012	Kaplan-Meier Survival Analysis
GBM	0.0027	Kaplan-Meier Survival Analysis
DLBC	0.031	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000197061 (Gene tree)
Gene ID: 8364
Gene Symbol: HIST1H4C
Alias: H4/g|dJ221C16.1|H4FG
Full Name: histone cluster 1 H4 family member c
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 462 bases
Position: chr6:26,103,876-26,104,337
Accession: 4787
RBP type: non-canonical RBP
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000377803	HIST1H4C-201	435	-	ENSP00000367034	103 (aa)	-	P62805

Gene Model

Click here to download ENSG00000197061's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05034	Alcoholism	KEGG
hsa05203	Viral carcinogenesis	KEGG
hsa05322	Systemic lupus erythematosus	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000197061	Blood Pressure	7.5980000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000197061	rs2229768	6	26104052	T	Heel bone mineral density	30598549	[0.0097-0.0181] unit increase	0.0138724	EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197061's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197061	HIST1H4C	100	99.029	WBGene00001941	his-67	100	99.029	Caenorhabditis_elegans
ENSG00000197061	HIST1H4C	100	100.000	ENSG00000276180	HIST1H4I	100	100.000	Homo_sapiens
ENSG00000197061	HIST1H4C	100	100.000	ENSG00000278705	HIST1H4B	100	100.000	Homo_sapiens
ENSG00000197061	HIST1H4C	100	100.000	ENSG00000276966	HIST1H4E	100	100.000	Homo_sapiens
ENSG00000197061	HIST1H4C	100	100.000	ENSG00000275126	HIST1H4L	100	100.000	Homo_sapiens
ENSG00000197061	HIST1H4C	100	100.000	ENSG00000197837	HIST4H4	100	100.000	Homo_sapiens
ENSG00000197061	HIST1H4C	100	100.000	ENSG00000274618	HIST1H4F	100	100.000	Homo_sapiens
ENSG00000197061	HIST1H4C	100	100.000	ENSG00000270882	HIST2H4A	100	100.000	Homo_sapiens
ENSG00000197061	HIST1H4C	100	100.000	ENSG00000270276	HIST2H4B	100	100.000	Homo_sapiens
ENSG00000197061	HIST1H4C	100	92.233	YBR009C		100	92.233	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000183	chromatin silencing at rDNA	-	TAS	Process
GO:0000228	nuclear chromosome	14718166.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000786	nucleosome	21636898.24699735.25615412.	IDA	Component
GO:0000786	nucleosome	3035717.	TAS	Component
GO:0000788	nuclear nucleosome	20498094.	IDA	Component
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003677	DNA binding	3035717.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	9540062.10220385.14585971.15161933.15933069.16415788.16917504.17540172.18404153.18408754.18474616.18571423.19410544.19494831.19498464.19710015.19862764.20000738.20224553.20498094.20618440.20709061.20739937.20951943.21085121.21478274.21596426.21743476.21888893.21983900.22343720.22368283.22373579.22615379.23071334.23075851.23142979.23377543.23760478.23831576.24183680.24360279.24361270.24525235.24596249.24726341.25281266.25416956.25556234.25579814.25619998.25651062.25910212.26167883.26496610.26912361.30021884.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	14585971.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	Process
GO:0006334	nucleosome assembly	21873635.	IBA	Process
GO:0006334	nucleosome assembly	20498094.21636898.24699735.25615412.	IDA	Process
GO:0006335	DNA replication-dependent nucleosome assembly	14718166.	IDA	Process
GO:0006336	DNA replication-independent nucleosome assembly	14718166.	IDA	Process
GO:0006352	DNA-templated transcription, initiation	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016233	telomere capping	-	TAS	Process
GO:0019904	protein domain specific binding	22368283.	IPI	Function
GO:0032200	telomere organization	17675446.	TAS	Process
GO:0032991	protein-containing complex	14718166.	IDA	Component
GO:0034080	CENP-A containing nucleosome assembly	-	TAS	Process
GO:0044267	cellular protein metabolic process	-	TAS	Process
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0045653	negative regulation of megakaryocyte differentiation	18474616.	IDA	Process
GO:0045814	negative regulation of gene expression, epigenetic	-	TAS	Process
GO:0046982	protein heterodimerization activity	-	IEA	Function
GO:0051290	protein heterotetramerization	20498094.	IDA	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0070062	extracellular exosome	19199708.20458337.23533145.	HDA	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.