EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18278455	Protein expression of BLM gene and its apoptosis sensitivity in hematopoietic tumor cell strains.	J Huazhong Univ Sci Technolog Med Sci	2008 Feb	Wang X	doi: 10.1007/s11596-008-0111-z.
19109166	Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage.	J Immunol	2009 Jan 1	Babbe H	-
19945966	Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM.	Carcinogenesis	2010 Mar	Frank B	doi: 10.1093/carcin/bgp293
24096176	A common nonsense mutation of the BLM gene and prostate cancer risk and survival.	Gene	2013 Dec 15	Antczak A	doi: 10.1016/j.gene.2013.09.079
26778106	The risk for developing cancer in Israeli ATM, BLM, and FANCC heterozygous mutation carriers.	Cancer Genet	2016 Mar	Laitman Y	doi: 10.1016/j.cancergen.2015.12.006
19432957	Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.	BMC Cancer	2009 May 11	Broberg K	doi: 10.1186/1471-2407-9-140.
24858046	Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.	Oncogene	2015 Apr 2	El Ghamrasni S	doi: 10.1038/onc.2014.121
18974064	Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility.	Carcinogenesis	2009 Jan	Ding SL	doi: 10.1093/carcin/bgn233
17457718	The broken genome: genetic and pharmacologic approaches to breaking DNA.	Ann Med	2007	Woo LL	-
12242432	BLM heterozygosity and the risk of colorectal cancer.	Science	2002 Sep 20	Gruber SB	-
25182961	Prevalence of the BLM nonsense mutation, p.Q548X, in ovarian cancer patients from Central and Eastern Europe.	Fam Cancer	2015 Mar	Bogdanova N	doi: 10.1007/s10689-014-9748-x.
25472581	Genome-wide haplotype association study identifies BLM as a risk gene for prostate cancer in Chinese population.	Tumour Biol	2015 Apr	Wang Q	doi: 10.1007/s13277-014-2893-x
21815139	High prevalence and breast cancer predisposing role of the BLM c.1642 C>T (Q548X) mutation in Russia.	Int J Cancer	2012 Jun 15	Sokolenko AP	doi: 10.1002/ijc.26342
16864798	MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability.	Proc Natl Acad Sci U S A	2006 Aug 1	Leng M	-
17855454	Genetic variation in the DNA repair genes is predictive of outcome in lung cancer.	Hum Mol Genet	2007 Oct 1	Matakidou A	-
23028338	Exome sequencing identifies rare deleterious mutations in DNA repair genes FANCC and BLM as potential breast cancer susceptibility alleles.	PLoS Genet	2012 Sep	Thompson ER	doi: 10.1371/journal.pgen.1002894
23225144	Nonsense mutation p.Q548X in BLM, the gene mutated in Bloom's syndrome, is associated with breast cancer in Slavic populations.	Breast Cancer Res Treat	2013 Jan	Prokofyeva D	doi: 10.1007/s10549-012-2357-1
25673821	Transcriptomic and Protein Expression Analysis Reveals Clinicopathological Significance of Bloom Syndrome Helicase (BLM) in Breast Cancer.	Mol Cancer Ther	2015 Apr	Arora A	doi: 10.1158/1535-7163.MCT-14-0939
23404160	BLM and RAD51 genes polymorphism and susceptibility to breast cancer.	Pathol Oncol Res	2013 Jul	Sassi A	doi: 10.1007/s12253-013-9602-8
27238185	Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.	Ageing Res Rev	2017 Jan	de Renty C	doi: 10.1016/j.arr.2016.05.010
27169843	Aberrant BLM cytoplasmic expression associates with DNA damage stress and hypersensitivity to DNA-damaging agents in colorectal cancer.	J Gastroenterol	2017 Mar	Votino C	doi: 10.1007/s00535-016-1222-0
27083049	BLM promotes the activation of Fanconi Anemia signaling pathway.	Oncotarget	2016 May 31	Panneerselvam J	doi: 10.18632/oncotarget.8707.
29386092	miR-522-3p Promotes Tumorigenesis in Human Colorectal Cancer via Targeting Bloom Syndrome Protein.	Oncol Res	2018 Aug 23	Shuai F	doi: 10.3727/096504018X15166199939341

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr15	90749596	Missense_Mutation	novel	D110N	0.15
BLCA	chr15	90754834	Missense_Mutation	novel	S328C	0.25
BLCA	chr15	90790761	Missense_Mutation	NA	R979T	0.07
BLCA	chr15	90809157	Missense_Mutation	novel	E1258K	0.08
BLCA	chr15	90769499	Missense_Mutation	novel	S823C	0.52	HRDC
BLCA	chr15	90798210	Silent	novel	V1077V	0.43
BLCA	chr15	90769509	Silent	novel	V826V	0.18
BLCA	chr15	90785020	Missense_Mutation	novel	G921V	0.21
BLCA	chr15	90790770	In_Frame_Ins	novel	R982_D983insNIFII	0.06
BLCA	chr15	90804238	Missense_Mutation	novel	Q1210H	0.24
BLCA	chr15	90798214	Missense_Mutation	NA	D1079N	0.52
BLCA	chr15	90747481	Missense_Mutation	NA	P30L	0.37
BLCA	chr15	90798210	Silent	novel	V1077V	0.17
BLCA	chr15	90803631	Missense_Mutation	novel	E1157K	0.43
BLCA	chr15	90760188	Missense_Mutation	novel	E377Q	0.34
BLCA	chr15	90763041	Missense_Mutation	NA	K653M	0.47
BLCA	chr15	90749450	Missense_Mutation	novel	R61K	0.33
BLCA	chr15	90798203	Missense_Mutation	NA	R1075T	0.06
BRCA	chr15	90769509	Silent	NA	V826V	0.25
BRCA	chr15	90811385	Missense_Mutation	NA	S1352F	0.23
BRCA	chr15	90809224	Missense_Mutation	NA	S1280L	0.24
BRCA	chr15	90762993	Missense_Mutation	NA	R637I	0.33
BRCA	chr15	90762994	Silent	NA	R637R	0.34
BRCA	chr15	90798290	Missense_Mutation	rs150784889	G1104D	0.03
BRCA	chr15	90749953	Missense_Mutation	NA	E229K	0.13
BRCA	chr15	90749962	Missense_Mutation	novel	S232C	0.27
BRCA	chr15	90803563	Missense_Mutation	novel	G1134E	0.05
BRCA	chr15	90769190	Silent	novel	L789L	0.05
BRCA	chr15	90761066	Missense_Mutation	NA	D565N	0.18
BRCA	chr15	90761138	Nonsense_Mutation	NA	E589*	0.2
BRCA	chr15	90750028	In_Frame_Del	novel	E254_S255del	0.39
BRCA	chr15	90747435	Missense_Mutation	rs148545569	R15C	0.18
BRCA	chr15	90769158	Missense_Mutation	novel	S778F	0.16	HRDC
BRCA	chr15	90798302	Missense_Mutation	novel	R1108T	0.05
BRCA	chr15	90754937	Splice_Region	rs375632163	D362D	0.09
BRCA	chr15	90803543	Missense_Mutation	NA	Q1127H	0.2
BRCA	chr15	90811252	Frame_Shift_Del	novel	*G1308Rfs89**	0.32
BRCA	chr15	90749818	Missense_Mutation	NA	Q184E	0.25
BRCA	chr15	90760057	Intron	novel		0.25
BRCA	chr15	90749491	Missense_Mutation	novel	E75K	0.1
BRCA	chr15	90811288	Missense_Mutation	NA	P1320S	0.11
CESC	chr15	90794320	Missense_Mutation	novel	H1058R	0.47
CESC	chr15	90809255	Silent	novel	S1290S	0.42
CESC	chr15	90760835	Missense_Mutation	NA	E488Q	0.23
CESC	chr15	90749601	Silent	NA	F111F	0.2
CESC	chr15	90815187	Missense_Mutation	novel	A1388T	0.42
CESC	chr15	90790674	Missense_Mutation	rs575498961	G950E	0.38
CESC	chr15	90760670	Missense_Mutation	novel	D433H	0.28
CESC	chr15	90784962	Missense_Mutation	novel	D902H	0.21
CESC	chr15	90815184	Missense_Mutation	novel	Q1387E	0.27
CESC	chr15	90751806	Silent	novel	K273K	0.19
CESC	chr15	90769442	Missense_Mutation	novel	G804V	0.1	HRDC
CESC	chr15	90751915	Frame_Shift_Ins	novel	*S310Cfs11**	0.28
CESC	chr15	90751916	Missense_Mutation	novel	S310C	0.28
CHOL	chr15	90766932	Missense_Mutation	novel	G739V	0.04	HRDC
COAD	chr15	90769138	Nonsense_Mutation	NA	C771*	0.19	HRDC
COAD	chr15	90763022	Missense_Mutation	NA	L647I	0.34
COAD	chr15	90815375	3'UTR	novel		0.4
COAD	chr15	90769437	Splice_Site	novel	X803_splice	0.21
COAD	chr15	90751870	Missense_Mutation	rs146096923	D295Y	0.38
COAD	chr15	90809140	Missense_Mutation	novel	S1252F	0.27
COAD	chr15	90763153	Silent	rs148078150	P690P	0.41
COAD	chr15	90815306	3'UTR	rs756815879		0.35
COAD	chr15	90811344	Missense_Mutation	NA	K1338N	0.3
COAD	chr15	90749831	Missense_Mutation	novel	K188R	0.33
COAD	chr15	90794229	Missense_Mutation	NA	H1028Y	0.24
COAD	chr15	90760909	Frame_Shift_Del	rs772495493	*N515Mfs16**	0.24
COAD	chr15	90760909	Frame_Shift_Del	rs772495493	*N515Mfs16**	0.51
COAD	chr15	90804254	Frame_Shift_Del	NA	*K1217Nfs62**	0.41
COAD	chr15	90782891	Silent	novel	A875A	0.3
COAD	chr15	90803577	Nonsense_Mutation	rs587783037	R1139*	0.14
COAD	chr15	90804254	Frame_Shift_Del	NA	*K1217Nfs62**	0.42
COAD	chr15	90784953	Nonsense_Mutation	rs587779884	R899*	0.27
COAD	chr15	90747490	Missense_Mutation	rs139282091	S33L	0.11
COAD	chr15	90749628	Silent	NA	C120C	0.21
COAD	chr15	90769176	Missense_Mutation	novel	Y784C	0.33	HRDC
COAD	chr15	90794186	Silent	rs747406569	H1013H	0.33
COAD	chr15	90803593	Missense_Mutation	NA	R1144I	0.19
COAD	chr15	90749592	Missense_Mutation	novel	L108F	0.07
COAD	chr15	90749593	In_Frame_Ins	novel	P109delinsLNT	0.07
COAD	chr15	90804264	Frame_Shift_Ins	novel	*G1220Pfs25**	0.09
COAD	chr15	90790701	Missense_Mutation	novel	R959L	0.37
ESCA	chr15	90749491	Missense_Mutation	novel	E75K	0.06
ESCA	chr15	90798241	Missense_Mutation	novel	V1088F	0.22
ESCA	chr15	90751793	Missense_Mutation	novel	S269T	0.24
GBM	chr15	90815414	3'UTR	novel		0.2
GBM	chr15	90769531	Missense_Mutation	NA	N834Y	0.44	HRDC
GBM	chr15	90769552	Frame_Shift_Ins	novel	*I841Tfs14**	0.1
GBM	chr15	90749568	Missense_Mutation	novel	Q100H	0.39
GBM	chr15	90762993	Missense_Mutation	NA	R637I	0.51
GBM	chr15	90769484	Missense_Mutation	rs780514723	R818H	0.42	HRDC
GBM	chr15	90767003	Missense_Mutation	novel	L763I	0.39	HRDC
GBM	chr15	90798336	Splice_Region	NA	L1119L	0.31
GBM	chr15	90790662	Missense_Mutation	novel	T946K	0.14
GBM	chr15	90803607	Missense_Mutation	novel	L1149M	0.04
GBM	chr15	90815414	3'UTR	novel		0.09
GBM	chr15	90760926	Missense_Mutation	novel	S518C	0.22
GBM	chr15	90765402	Silent	novel	L727L	0.05
HNSC	chr15	90760665	Missense_Mutation	novel	R431K	0.16
HNSC	chr15	90804185	Missense_Mutation	novel	E1193Q	0.07
HNSC	chr15	90761009	Missense_Mutation	novel	E546Q	0.08
HNSC	chr15	90765365	Missense_Mutation	NA	P715L	0.47	HRDC
HNSC	chr15	90769577	Missense_Mutation	novel	R849T	0.13
HNSC	chr15	90803588	Silent	rs147148171	A1142A	0.25
HNSC	chr15	90760904	Missense_Mutation	novel	L511I	0.11
KIRC	chr15	90751822	Missense_Mutation	NA	E279K	0.33
KIRC	chr15	90749641	Missense_Mutation	NA	T125P	0.11
KIRC	chr15	90749717	Missense_Mutation	NA	T150I	0.24
KIRC	chr15	90803582	Missense_Mutation	NA	H1140Q	0.2
KIRC	chr15	90760976	Missense_Mutation	NA	K535Q	0.28
KIRP	chr15	90754893	Missense_Mutation	novel	M348V	0.49
LAML	chr15	90815326	3'UTR	novel		0.09
LGG	chr15	90766955	Missense_Mutation	novel	T747A	0.15	HRDC
LGG	chr15	90747435	Missense_Mutation	rs148545569	R15C	0.39
LIHC	chr15	90815253	Missense_Mutation	novel	L1410I	0.11
LIHC	chr15	90749804	Missense_Mutation	novel	R179I	0.12
LIHC	chr15	90803635	Missense_Mutation	NA	D1158G	0.31
LIHC	chr15	90766977	Frame_Shift_Ins	novel	*D757Rfs18**	0.25	HRDC
LIHC	chr15	90804313	Silent	NA	V1235V	0.22
LUAD	chr15	90798237	Frame_Shift_Ins	novel	*V1088Lfs11**	0.2
LUAD	chr15	90749533	Missense_Mutation	novel	F89L	0.09
LUAD	chr15	90766943	Missense_Mutation	NA	D743N	0.11	HRDC
LUAD	chr15	90769512	Missense_Mutation	NA	M827I	0.19	HRDC
LUAD	chr15	90749839	Missense_Mutation	novel	R191G	0.14
LUAD	chr15	90794236	Missense_Mutation	novel	C1030F	0.07
LUAD	chr15	90760659	Missense_Mutation	rs761195071	R429K	0.06
LUAD	chr15	90798261	Silent	NA	S1094S	0.45
LUSC	chr15	90765319	Nonsense_Mutation	rs367543028	Q700*	0.11	HRDC
LUSC	chr15	90750001	Nonsense_Mutation	novel	E245*	0.34
LUSC	chr15	90769493	Missense_Mutation	novel	F821S	0.38	HRDC
LUSC	chr15	90749819	Missense_Mutation	NA	Q184L	0.4
LUSC	chr15	90769453	Missense_Mutation	rs759330541	R808C	0.36	HRDC
LUSC	chr15	90769499	Missense_Mutation	NA	S823F	0.07	HRDC
LUSC	chr15	90760110	Intron	novel		0.14
LUSC	chr15	90749792	Missense_Mutation	novel	S175I	0.21
LUSC	chr15	90751805	Missense_Mutation	novel	K273R	0.44
LUSC	chr15	90761221	Frame_Shift_Ins	novel	*I617Yfs15**	0.09
LUSC	chr15	90790843	Missense_Mutation	novel	M1006I	0.29
LUSC	chr15	90766969	Silent	novel	L751L	0.3
OV	chr15	90815323	3'UTR	novel		0.06
OV	chr15	90809220	Missense_Mutation	NA	I1279V	0.39
OV	chr15	90749523	Missense_Mutation	NA	R85S	0.32
OV	chr15	90747481	Missense_Mutation	NA	P30R	0.16
OV	chr15	90765409	Frame_Shift_Ins	novel	*L730Cfs11**	0.05	HRDC
OV	chr15	90769520	Missense_Mutation	rs759545027	T830M	0.39	HRDC
OV	chr15	90815414	3'UTR	novel		0.17
OV	chr15	90760145	Splice_Site	novel	X363_splice	0.16
PAAD	chr15	90760712	Missense_Mutation	novel	G447R	0.17
PAAD	chr15	90784998	Missense_Mutation	rs372013507	A914T	0.19
PAAD	chr15	90803596	Missense_Mutation	novel	L1145R	0.18
PAAD	chr15	90804278	Nonsense_Mutation	novel	E1224*	0.19
PRAD	chr15	90803609	Silent	novel	L1149L	0.22
READ	chr15	90769186	Silent	novel	K787K	0.07
READ	chr15	90760909	Frame_Shift_Del	rs772495493	*N515Mfs16**	0.5
READ	chr15	90749561	Missense_Mutation	novel	E98G	0.05
READ	chr15	90760758	Missense_Mutation	novel	S462Y	0.07
READ	chr15	90798239	Missense_Mutation	NA	F1087C	0.14
READ	chr15	90749708	Missense_Mutation	novel	S147Y	0.36
READ	chr15	90809140	Missense_Mutation	NA	S1252Y	0.16
SARC	chr15	90749613	Silent	rs374578971	P115P	0.09
SKCM	chr15	90815099	Splice_Region	novel		0.42
SKCM	chr15	90790646	Splice_Region	novel		0.65
SKCM	chr15	90749373	Silent	novel	F35F	0.37
SKCM	chr15	90754854	Missense_Mutation	novel	L335F	0.27
SKCM	chr15	90749662	Missense_Mutation	rs765089689	R132W	0.12
SKCM	chr15	90769483	Missense_Mutation	NA	R818C	0.41	HRDC
SKCM	chr15	90754937	Splice_Region	rs375632163	D362D	0.16
SKCM	chr15	90809153	Missense_Mutation	NA	D1256E	0.15
SKCM	chr15	90749601	Silent	NA	F111F	0.35
SKCM	chr15	90785004	Missense_Mutation	novel	L916F	0.41
SKCM	chr15	90811370	Missense_Mutation	novel	R1347K	0.38
SKCM	chr15	90811371	Silent	novel	R1347R	0.37
SKCM	chr15	90751809	Silent	NA	N274N	0.22
SKCM	chr15	90766962	Missense_Mutation	novel	I749N	0.25	HRDC
SKCM	chr15	90749411	Missense_Mutation	NA	S48F	0.34
SKCM	chr15	90803540	Silent	NA	I1126I	0.06
SKCM	chr15	90749903	Missense_Mutation	rs777938065	S212F	0.37
SKCM	chr15	90811230	Silent	rs769564626	S1300S	0.24
SKCM	chr15	90765324	Silent	NA	L701L	0.07
SKCM	chr15	90815132	Silent	novel	S1369S	0.38
SKCM	chr15	90769453	Missense_Mutation	rs759330541	R808C	0.45	HRDC
STAD	chr15	90751848	Silent	NA	P287P	0.21
STAD	chr15	90769454	Missense_Mutation	NA	R808H	0.51	HRDC
STAD	chr15	90760851	Missense_Mutation	NA	N493S	0.07
STAD	chr15	90749613	Silent	rs374578971	P115P	0.51
STAD	chr15	90769175	Frame_Shift_Del	novel	Y784*	0.15	HRDC
STAD	chr15	90790700	Nonsense_Mutation	rs762354041	R959*	0.3
STAD	chr15	90811348	Missense_Mutation	NA	P1340T	0.38
STAD	chr15	90749565	Silent	NA	T99T	0.08
STAD	chr15	90766978	Frame_Shift_Del	rs747341586	*D757Tfs4**	0.23	HRDC
STAD	chr15	90760909	Frame_Shift_Del	rs772495493	*N515Mfs16**	0.27
STAD	chr15	90803589	Missense_Mutation	rs140387675	E1143K	0.22
STAD	chr15	90815180	Silent	NA	T1385T	0.3
STAD	chr15	90815254	Missense_Mutation	NA	L1410R	0.08
STAD	chr15	90763133	Missense_Mutation	NA	D684Y	0.2	HRDC
STAD	chr15	90749725	Missense_Mutation	novel	D153Y	0.05
STAD	chr15	90766978	Frame_Shift_Del	rs747341586	*D757Tfs4**	0.28	HRDC
STAD	chr15	90811252	Missense_Mutation	rs768010078	G1308R	0.08
STAD	chr15	90811269	Missense_Mutation	novel	E1313D	0.32
STAD	chr15	90751862	Missense_Mutation	NA	D292G	0.08
STAD	chr15	90760909	Frame_Shift_Del	rs772495493	*N515Mfs16**	0.4
THCA	chr15	90761221	Frame_Shift_Ins	novel	*I617Yfs15**	0.08
UCEC	chr15	90809159	Missense_Mutation	novel	E1258D	0.25
UCEC	chr15	90815320	3'UTR	novel		0.36
UCEC	chr15	90749590	Silent	novel	L108L	0.21
UCEC	chr15	90794294	Silent	NA	G1049G	0.36
UCEC	chr15	90751886	Missense_Mutation	novel	F300C	0.32
UCEC	chr15	90803557	Missense_Mutation	rs754915610	G1132V	0.36
UCEC	chr15	90760686	Missense_Mutation	novel	P438H	0.41
UCEC	chr15	90804167	Missense_Mutation	NA	V1187L	0.3
UCEC	chr15	90785061	Missense_Mutation	rs774916971	I935V	0.34
UCEC	chr15	90749745	Missense_Mutation	novel	D159E	0.34
UCEC	chr15	90784937	Missense_Mutation	novel	I893M	0.38
UCEC	chr15	90749559	Missense_Mutation	novel	Q97H	0.31
UCEC	chr15	90751806	Missense_Mutation	novel	K273N	0.34
UCEC	chr15	90749546	Missense_Mutation	NA	A93D	0.21
UCEC	chr15	90754901	Missense_Mutation	rs745469404	M350I	0.17
UCEC	chr15	90761171	Missense_Mutation	NA	L600F	0.12
UCEC	chr15	90815429	3'UTR	novel		0.4
UCEC	chr15	90751860	Silent	NA	F291F	0.16
UCEC	chr15	90754869	Missense_Mutation	NA	D340Y	0.26
UCEC	chr15	90798285	Silent	novel	H1102H	0.16
UCEC	chr15	90769217	Missense_Mutation	novel	H798Y	0.05	HRDC
UCEC	chr15	90769505	Missense_Mutation	NA	P825Q	0.41	HRDC
UCEC	chr15	90760273	Missense_Mutation	novel	N405S	0.45
UCEC	chr15	90760810	Missense_Mutation	novel	F479L	0.4
UCEC	chr15	90794196	Missense_Mutation	novel	E1017K	0.1
UCEC	chr15	90760266	Nonsense_Mutation	novel	Q403*	0.4
UCEC	chr15	90762980	Missense_Mutation	novel	N633H	0.21
UCEC	chr15	90804254	Frame_Shift_Del	NA	*K1217Nfs62**	0.28
UCEC	chr15	90766978	Frame_Shift_Del	rs747341586	*D757Tfs4**	0.41	HRDC
UCEC	chr15	90760683	Missense_Mutation	novel	G437V	0.48
UCEC	chr15	90790799	Missense_Mutation	novel	F992V	0.53
UCEC	chr15	90815273	Missense_Mutation	novel	F1416L	0.51
UCEC	chr15	90760909	Frame_Shift_Del	rs772495493	*N515Mfs16**	0.51
UCEC	chr15	90803666	Silent	novel	I1168I	0.08
UCEC	chr15	90803588	Silent	rs147148171	A1142A	0.42
UCEC	chr15	90749991	Silent	NA	G241G	0.08
UCEC	chr15	90760719	Missense_Mutation	novel	S449Y	0.52
UCEC	chr15	90760833	Missense_Mutation	novel	F487C	0.5
UCEC	chr15	90782858	Silent	novel	Y864Y	0.39
UCEC	chr15	90754939	Splice_Site	novel	X363_splice	0.37
UCEC	chr15	90760825	Missense_Mutation	novel	K484N	0.46
UCEC	chr15	90760632	Missense_Mutation	rs773952896	D420G	0.42
UCEC	chr15	90794081	Intron	novel		0.44
UCEC	chr15	90794250	Nonsense_Mutation	novel	E1035*	0.31
UCEC	chr15	90760758	Missense_Mutation	novel	S462Y	0.35
UCEC	chr15	90798257	Nonsense_Mutation	novel	S1093*	0.05
UCEC	chr15	90815289	3'UTR	novel		0.1
UCEC	chr15	90811348	Missense_Mutation	NA	P1340S	0.28
UCEC	chr15	90809142	Missense_Mutation	novel	L1253V	0.38
UCEC	chr15	90749967	Silent	rs200125311	S233S	0.31
UCEC	chr15	90784978	Missense_Mutation	rs367953471	T907M	0.29
UCEC	chr15	90763010	Missense_Mutation	rs373090621	R643C	0.4
UCEC	chr15	90763042	Missense_Mutation	novel	K653N	0.47
UCEC	chr15	90769564	Silent	novel	L845L	0.29
UCEC	chr15	90749692	Frame_Shift_Ins	novel	*S142Ifs13**	0.11
UCEC	chr15	90769553	Frame_Shift_Ins	novel	*L842Rfs6**	0.2
UCEC	chr15	90782850	Silent	NA	L862L	0.47
UCEC	chr15	90784996	Missense_Mutation	novel	L913R	0.52
UCEC	chr15	90804188	Missense_Mutation	novel	N1194H	0.08
UCEC	chr15	90749473	Missense_Mutation	rs746195311	E69K	0.3
UCEC	chr15	90749840	Missense_Mutation	rs569086568	R191I	0.26
UCEC	chr15	90751898	Missense_Mutation	novel	S304Y	0.18
UCEC	chr15	90760116	Intron	novel		0.21
UCEC	chr15	90769135	Splice_Region	novel	I770I	0.23
UCEC	chr15	90790759	Silent	novel	G978G	0.44
UCEC	chr15	90798261	Silent	NA	S1094S	0.33
UCEC	chr15	90749635	Frame_Shift_Ins	novel	*N124Kfs19**	0.34
UCEC	chr15	90803613	Missense_Mutation	novel	L1151F	0.09

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2203	0.0058042
ESCA	AMP	0.25	0.10665
LGG	AMP	0.0234	0.19963
LIHC	DEL	0.1757	0.056724
PAAD	AMP	0.0761	0.20695
SKCM	AMP	0.2589	9.6912e-06

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0029	Kaplan-Meier Survival Analysis
KIRC	0.00011	Kaplan-Meier Survival Analysis
SARC	0.003	Kaplan-Meier Survival Analysis
MESO	0.00013	Kaplan-Meier Survival Analysis
ACC	0.00018	Kaplan-Meier Survival Analysis
SKCM	0.011	Kaplan-Meier Survival Analysis
LUSC	0.021	Kaplan-Meier Survival Analysis
KIRP	0.00014	Kaplan-Meier Survival Analysis
PAAD	0.0088	Kaplan-Meier Survival Analysis
BLCA	0.034	Kaplan-Meier Survival Analysis
CESC	0.016	Kaplan-Meier Survival Analysis
KICH	0.0034	Kaplan-Meier Survival Analysis
UCEC	0.037	Kaplan-Meier Survival Analysis
LIHC	0.0011	Kaplan-Meier Survival Analysis
LGG	0.00014	Kaplan-Meier Survival Analysis
CHOL	0.0092	Kaplan-Meier Survival Analysis
LUAD	0.0005	Kaplan-Meier Survival Analysis
OV	0.014	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000197299 (Gene tree)
Gene ID: 641
Gene Symbol: BLM
Alias: BS|RECQL3|RECQ2
Full Name: BLM RecQ like helicase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 98,839 bases
Position: chr15:90,717,327-90,816,165
Accession: 1058
RBP type: canonical RBP
Summary: The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000347232	HRDC	PF00570.23	2.2e-11	1	1
ENSP00000454158	BDHCT	PF08072.11	1.1e-20	1	1
ENSP00000347232	BDHCT	PF08072.11	1.3e-20	1	1
ENSP00000347232	DEAD	PF00270.29	5.4e-19	1	1
ENSP00000454158	DEAD	PF00270.29	5.8e-19	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000560559	BLM-209	747	-	-	- (aa)	-	-
ENST00000559426	BLM-205	533	-	-	- (aa)	-	-
ENST00000560136	BLM-207	2023	-	-	- (aa)	-	-
ENST00000558825	BLM-203	1683	-	-	- (aa)	-	-
ENST00000355112	BLM-201	5258	XM_006720632	ENSP00000347232	1417 (aa)	XP_006720695	P54132
ENST00000558599	BLM-202	577	-	-	- (aa)	-	-
ENST00000648453	BLM-211	4522	-	ENSP00000497646	1386 (aa)	-	-
ENST00000559282	BLM-204	866	-	-	- (aa)	-	-
ENST00000560821	BLM-210	1024	-	-	- (aa)	-	-
ENST00000559724	BLM-206	4510	-	ENSP00000453359	413 (aa)	-	H0YLV8
ENST00000560509	BLM-208	3966	-	ENSP00000454158	1286 (aa)	-	H0YNU5

Gene Model

Click here to download ENSG00000197299's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03440	Homologous recombination	KEGG
hsa03460	Fanconi anemia pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000197299	Erythropoietin	2.8840000E-005	-
ENSG00000197299	alpha-Tocopherol	5.4590000E-005	-
ENSG00000197299	delta-5 fatty acid desaturase	8E-6	26584805
ENSG00000197299	Rest	9E-6	27126917
ENSG00000197299	delta-5 fatty acid desaturase	4E-6	26584805
ENSG00000197299	Asthma	1E-6	25918132
ENSG00000197299	Toluene 2,4-Diisocyanate	1E-6	25918132

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000197299	rs35787687	15	90737980	C	Daytime sleep phenotypes	27126917	[0.051-0.131] unit increase	0.09091	EFO_0007828
ENSG00000197299	rs3815003	15	90769593	T	Delta-5 desaturase activity	26584805	[0.038-0.096] unit increase	0.067	EFO_0007764
ENSG00000197299	rs8031341	15	90769994	G	Delta-5 desaturase activity	26584805	[0.039-0.098] unit decrease	0.0687	EFO_0007764

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197299's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197299	BLM	50	73.770	ENSAPOG00000017966	blm	58	65.561	Acanthochromis_polyacanthus
ENSG00000197299	BLM	100	81.786	ENSAMEG00000013843	BLM	100	81.364	Ailuropoda_melanoleuca
ENSG00000197299	BLM	50	74.433	ENSACIG00000023762	blm	56	65.217	Amphilophus_citrinellus
ENSG00000197299	BLM	50	73.361	ENSAOCG00000003318	blm	57	65.565	Amphiprion_ocellaris
ENSG00000197299	BLM	50	73.156	ENSAPEG00000018105	blm	56	65.565	Amphiprion_percula
ENSG00000197299	BLM	82	74.590	ENSATEG00000006421	blm	60	66.751	Anabas_testudineus
ENSG00000197299	BLM	81	58.583	ENSAPLG00000006878	BLM	98	58.221	Anas_platyrhynchos
ENSG00000197299	BLM	74	58.163	ENSACAG00000014275	BLM	52	74.415	Anolis_carolinensis
ENSG00000197299	BLM	100	93.013	ENSANAG00000038415	BLM	100	92.731	Aotus_nancymaae
ENSG00000197299	BLM	87	69.485	ENSACLG00000020354	blm	60	62.720	Astatotilapia_calliptera
ENSG00000197299	BLM	82	51.053	ENSAMXG00000016970	blm	75	54.283	Astyanax_mexicanus
ENSG00000197299	BLM	93	84.211	ENSBTAG00000020301	BLM	100	84.718	Bos_taurus
ENSG00000197299	BLM	100	92.731	ENSCJAG00000009803	BLM	100	92.616	Callithrix_jacchus
ENSG00000197299	BLM	100	82.581	ENSCAFG00000012385	BLM	100	82.581	Canis_familiaris
ENSG00000197299	BLM	100	82.511	ENSCAFG00020016111	BLM	94	92.476	Canis_lupus_dingo
ENSG00000197299	BLM	100	81.748	ENSCHIG00000010329	BLM	100	82.566	Capra_hircus
ENSG00000197299	BLM	100	86.822	ENSTSYG00000012368	BLM	100	86.822	Carlito_syrichta
ENSG00000197299	BLM	86	85.384	ENSCAPG00000017976	BLM	99	85.384	Cavia_aperea
ENSG00000197299	BLM	100	79.042	ENSCPOG00000001761	BLM	100	78.255	Cavia_porcellus
ENSG00000197299	BLM	100	91.602	ENSCCAG00000023069	BLM	100	91.320	Cebus_capucinus
ENSG00000197299	BLM	100	96.048	ENSCATG00000040609	BLM	100	96.048	Cercocebus_atys
ENSG00000197299	BLM	100	79.563	ENSCLAG00000012111	BLM	100	79.704	Chinchilla_lanigera
ENSG00000197299	BLM	100	95.228	ENSCSAG00000017040	BLM	100	95.228	Chlorocebus_sabaeus
ENSG00000197299	BLM	87	95.349	ENSCHOG00000006255	BLM	80	95.349	Choloepus_hoffmanni
ENSG00000197299	BLM	89	54.773	ENSCPBG00000025000	BLM	98	73.140	Chrysemys_picta_bellii
ENSG00000197299	BLM	89	98.889	ENSCANG00000034808	BLM	100	98.889	Colobus_angolensis_palliatus
ENSG00000197299	BLM	100	78.762	ENSCGRG00001024897	Blm	100	78.973	Cricetulus_griseus_chok1gshd
ENSG00000197299	BLM	90	58.933	ENSCGRG00000016261	Blm	97	74.557	Cricetulus_griseus_crigri
ENSG00000197299	BLM	89	48.547	ENSCSEG00000013483	blm	80	53.565	Cynoglossus_semilaevis
ENSG00000197299	BLM	50	74.385	ENSDARG00000077089	blm	56	65.740	Danio_rerio
ENSG00000197299	BLM	99	81.219	ENSDNOG00000010159	BLM	99	81.149	Dasypus_novemcinctus
ENSG00000197299	BLM	74	80.861	ENSDORG00000011033	Blm	100	80.766	Dipodomys_ordii
ENSG00000197299	BLM	52	41.789	FBgn0002906	Blm	50	41.184	Drosophila_melanogaster
ENSG00000197299	BLM	85	85.714	ENSETEG00000015019	BLM	77	85.714	Echinops_telfairi
ENSG00000197299	BLM	100	82.863	ENSEASG00005006727	BLM	100	82.158	Equus_asinus_asinus
ENSG00000197299	BLM	100	84.696	ENSECAG00000011405	BLM	100	83.997	Equus_caballus
ENSG00000197299	BLM	98	74.855	ENSEEUG00000001434	BLM	98	74.783	Erinaceus_europaeus
ENSG00000197299	BLM	89	75.820	ENSELUG00000019098	blm	50	75.820	Esox_lucius
ENSG00000197299	BLM	100	81.408	ENSFCAG00000006087	BLM	100	81.408	Felis_catus
ENSG00000197299	BLM	75	58.249	ENSFALG00000010981	BLM	89	55.806	Ficedula_albicollis
ENSG00000197299	BLM	100	74.850	ENSFDAG00000012658	BLM	100	72.702	Fukomys_damarensis
ENSG00000197299	BLM	69	61.432	ENSFHEG00000002553	blm	57	64.796	Fundulus_heteroclitus
ENSG00000197299	BLM	83	71.959	ENSGMOG00000016431	blm	90	61.607	Gadus_morhua
ENSG00000197299	BLM	99	50.441	ENSGALG00000008256	BLM	99	50.204	Gallus_gallus
ENSG00000197299	BLM	54	73.566	ENSGAFG00000001117	blm	63	65.173	Gambusia_affinis
ENSG00000197299	BLM	65	73.975	ENSGACG00000010863	blm	100	73.913	Gasterosteus_aculeatus
ENSG00000197299	BLM	90	52.242	ENSGAGG00000005383	BLM	94	78.211	Gopherus_agassizii
ENSG00000197299	BLM	100	99.401	ENSGGOG00000007710	BLM	100	99.401	Gorilla_gorilla
ENSG00000197299	BLM	87	69.485	ENSHBUG00000015943	blm	60	62.954	Haplochromis_burtoni
ENSG00000197299	BLM	100	81.479	ENSHGLG00000013231	BLM	99	81.338	Heterocephalus_glaber_female
ENSG00000197299	BLM	71	58.056	ENSHCOG00000011455	blm	99	54.554	Hippocampus_comes
ENSG00000197299	BLM	74	55.238	ENSIPUG00000000529	blm	85	54.468	Ictalurus_punctatus
ENSG00000197299	BLM	100	82.419	ENSSTOG00000005000	BLM	100	82.841	Ictidomys_tridecemlineatus
ENSG00000197299	BLM	66	88.291	ENSJJAG00000016322	Blm	94	88.133	Jaculus_jaculus
ENSG00000197299	BLM	89	63.614	ENSKMAG00000016608	blm	75	54.194	Kryptolebias_marmoratus
ENSG00000197299	BLM	98	52.367	ENSLACG00000006490	BLM	99	51.495	Latimeria_chalumnae
ENSG00000197299	BLM	87	67.438	ENSLOCG00000014302	blm	86	62.162	Lepisosteus_oculatus
ENSG00000197299	BLM	100	96.048	ENSMFAG00000042982	BLM	100	96.048	Macaca_fascicularis
ENSG00000197299	BLM	100	96.119	ENSMMUG00000019526	BLM	100	96.119	Macaca_mulatta
ENSG00000197299	BLM	99	94.012	ENSMNEG00000031251	BLM	92	98.652	Macaca_nemestrina
ENSG00000197299	BLM	100	94.611	ENSMLEG00000032934	BLM	100	93.578	Mandrillus_leucophaeus
ENSG00000197299	BLM	56	68.794	ENSMAMG00000008726	blm	57	66.918	Mastacembelus_armatus
ENSG00000197299	BLM	87	69.485	ENSMZEG00005022323	blm	62	64.757	Maylandia_zebra
ENSG00000197299	BLM	100	78.581	ENSMAUG00000008953	Blm	99	78.652	Mesocricetus_auratus
ENSG00000197299	BLM	100	86.549	ENSMICG00000034442	BLM	100	86.479	Microcebus_murinus
ENSG00000197299	BLM	100	76.988	ENSMOCG00000016367	Blm	99	76.508	Microtus_ochrogaster
ENSG00000197299	BLM	63	73.347	ENSMMOG00000006959	blm	61	65.645	Mola_mola
ENSG00000197299	BLM	99	64.874	ENSMODG00000019449	BLM	99	64.670	Monodelphis_domestica
ENSG00000197299	BLM	68	68.327	ENSMALG00000007323	blm	63	63.518	Monopterus_albus
ENSG00000197299	BLM	100	75.526	MGP_CAROLIEiJ_G0029907	Blm	100	75.053	Mus_caroli
ENSG00000197299	BLM	100	75.855	ENSMUSG00000030528	Blm	100	75.384	Mus_musculus
ENSG00000197299	BLM	100	76.772	MGP_PahariEiJ_G0013129	Blm	100	76.297	Mus_pahari
ENSG00000197299	BLM	100	76.367	MGP_SPRETEiJ_G0031009	Blm	100	75.806	Mus_spretus
ENSG00000197299	BLM	87	80.088	ENSMPUG00000015657	BLM	99	80.365	Mustela_putorius_furo
ENSG00000197299	BLM	100	80.056	ENSMLUG00000014697	BLM	100	80.407	Myotis_lucifugus
ENSG00000197299	BLM	100	80.973	ENSNGAG00000001275	Blm	100	80.197	Nannospalax_galili
ENSG00000197299	BLM	82	75.258	ENSNBRG00000019702	blm	61	66.113	Neolamprologus_brichardi
ENSG00000197299	BLM	100	97.605	ENSNLEG00000012087	BLM	100	97.605	Nomascus_leucogenys
ENSG00000197299	BLM	99	61.469	ENSMEUG00000007253	BLM	99	61.329	Notamacropus_eugenii
ENSG00000197299	BLM	95	94.444	ENSOPRG00000011667	BLM	95	86.445	Ochotona_princeps
ENSG00000197299	BLM	74	79.079	ENSODEG00000015373	BLM	100	79.079	Octodon_degus
ENSG00000197299	BLM	55	69.541	ENSONIG00000015193	blm	60	62.763	Oreochromis_niloticus
ENSG00000197299	BLM	54	82.682	ENSOANG00000009316	-	99	81.795	Ornithorhynchus_anatinus
ENSG00000197299	BLM	99	75.405	ENSOCUG00000013969	BLM	99	75.123	Oryctolagus_cuniculus
ENSG00000197299	BLM	82	69.505	ENSORLG00000008110	blm	61	66.371	Oryzias_latipes
ENSG00000197299	BLM	83	74.180	ENSORLG00020004812	blm	57	66.539	Oryzias_latipes_hni
ENSG00000197299	BLM	82	70.293	ENSORLG00015018640	blm	78	66.496	Oryzias_latipes_hsok
ENSG00000197299	BLM	63	73.770	ENSOMEG00000023545	blm	64	66.028	Oryzias_melastigma
ENSG00000197299	BLM	100	80.479	ENSOGAG00000005708	BLM	100	79.085	Otolemur_garnettii
ENSG00000197299	BLM	100	80.656	ENSOARG00000012875	BLM	100	80.796	Ovis_aries
ENSG00000197299	BLM	100	98.802	ENSPPAG00000032173	BLM	100	98.802	Pan_paniscus
ENSG00000197299	BLM	100	81.338	ENSPPRG00000002471	BLM	100	81.338	Panthera_pardus
ENSG00000197299	BLM	100	81.013	ENSPTIG00000016168	BLM	100	81.013	Panthera_tigris_altaica
ENSG00000197299	BLM	100	98.518	ENSPTRG00000007460	BLM	100	98.518	Pan_troglodytes
ENSG00000197299	BLM	100	96.189	ENSPANG00000018572	BLM	100	96.189	Papio_anubis
ENSG00000197299	BLM	52	67.310	ENSPMGG00000006629	blm	80	67.448	Periophthalmus_magnuspinnatus
ENSG00000197299	BLM	100	77.989	ENSPEMG00000017348	Blm	100	77.637	Peromyscus_maniculatus_bairdii
ENSG00000197299	BLM	51	59.301	ENSPMAG00000000445	blm	96	59.441	Petromyzon_marinus
ENSG00000197299	BLM	99	64.286	ENSPCIG00000006609	BLM	99	63.915	Phascolarctos_cinereus
ENSG00000197299	BLM	54	73.770	ENSPFOG00000005059	blm	59	65.301	Poecilia_formosa
ENSG00000197299	BLM	54	73.770	ENSPLAG00000017344	blm	59	65.045	Poecilia_latipinna
ENSG00000197299	BLM	54	73.770	ENSPMEG00000000321	blm	59	65.301	Poecilia_mexicana
ENSG00000197299	BLM	54	73.361	ENSPREG00000007715	blm	59	65.045	Poecilia_reticulata
ENSG00000197299	BLM	100	98.802	ENSPPYG00000006784	BLM	100	95.483	Pongo_abelii
ENSG00000197299	BLM	73	93.939	ENSPCAG00000008960	BLM	73	93.939	Procavia_capensis
ENSG00000197299	BLM	100	84.431	ENSPCOG00000000439	BLM	100	84.431	Propithecus_coquereli
ENSG00000197299	BLM	81	95.527	ENSPVAG00000011642	BLM	88	95.527	Pteropus_vampyrus
ENSG00000197299	BLM	59	51.529	ENSPNYG00000010956	blm	57	50.696	Pundamilia_nyererei
ENSG00000197299	BLM	57	69.014	ENSPNAG00000011714	blm	79	52.986	Pygocentrus_nattereri
ENSG00000197299	BLM	100	75.158	ENSRNOG00000011213	Blm	100	74.455	Rattus_norvegicus
ENSG00000197299	BLM	100	95.210	ENSRBIG00000029656	BLM	100	96.257	Rhinopithecus_bieti
ENSG00000197299	BLM	100	95.210	ENSRROG00000037871	BLM	100	95.210	Rhinopithecus_roxellana
ENSG00000197299	BLM	100	91.680	ENSSBOG00000030957	BLM	100	91.904	Saimiri_boliviensis_boliviensis
ENSG00000197299	BLM	99	64.951	ENSSHAG00000007988	BLM	99	65.090	Sarcophilus_harrisii
ENSG00000197299	BLM	71	55.533	ENSSFOG00015015462	blm	63	65.128	Scleropages_formosus
ENSG00000197299	BLM	66	65.052	ENSSMAG00000001120	blm	76	53.747	Scophthalmus_maximus
ENSG00000197299	BLM	50	74.590	ENSSDUG00000010955	blm	56	66.158	Seriola_dumerili
ENSG00000197299	BLM	50	74.180	ENSSLDG00000000634	blm	56	66.031	Seriola_lalandi_dorsalis
ENSG00000197299	BLM	93	73.653	ENSSARG00000006398	BLM	99	70.668	Sorex_araneus
ENSG00000197299	BLM	80	56.892	ENSSPUG00000000013	BLM	93	59.091	Sphenodon_punctatus
ENSG00000197299	BLM	51	73.566	ENSSPAG00000013999	blm	56	65.944	Stegastes_partitus
ENSG00000197299	BLM	100	82.320	ENSSSCG00000001816	BLM	99	83.176	Sus_scrofa
ENSG00000197299	BLM	77	54.756	ENSTGUG00000009959	-	99	50.992	Taeniopygia_guttata
ENSG00000197299	BLM	60	72.951	ENSTRUG00000019860	blm	60	61.229	Takifugu_rubripes
ENSG00000197299	BLM	77	90.909	ENSTBEG00000006706	BLM	81	85.255	Tupaia_belangeri
ENSG00000197299	BLM	100	84.014	ENSTTRG00000016386	BLM	100	84.507	Tursiops_truncatus
ENSG00000197299	BLM	100	81.901	ENSUMAG00000009105	BLM	97	93.023	Ursus_maritimus
ENSG00000197299	BLM	99	80.902	ENSVPAG00000000085	BLM	99	80.832	Vicugna_pacos
ENSG00000197299	BLM	95	94.700	ENSVVUG00000006402	BLM	100	90.110	Vulpes_vulpes
ENSG00000197299	BLM	99	51.534	ENSXETG00000007847	blm	54	72.879	Xenopus_tropicalis
ENSG00000197299	BLM	50	67.828	ENSXCOG00000020227	blm	55	61.509	Xiphophorus_couchianus
ENSG00000197299	BLM	50	72.746	ENSXMAG00000002951	blm	56	64.661	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	21873635.	IBA	Process
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	15604258.	IMP	Process
GO:0000228	nuclear chromosome	21873635.	IBA	Component
GO:0000228	nuclear chromosome	23509288.	IDA	Component
GO:0000400	four-way junction DNA binding	21873635.	IBA	Function
GO:0000400	four-way junction DNA binding	11735402.20639533.25901030.	IDA	Function
GO:0000403	Y-form DNA binding	21873635.	IBA	Function
GO:0000403	Y-form DNA binding	11735402.	IDA	Function
GO:0000405	bubble DNA binding	21873635.	IBA	Function
GO:0000405	bubble DNA binding	11433031.11735402.	IDA	Function
GO:0000712	resolution of meiotic recombination intermediates	21873635.	IBA	Process
GO:0000724	double-strand break repair via homologous recombination	21873635.	IBA	Process
GO:0000724	double-strand break repair via homologous recombination	11309417.	NAS	Process
GO:0000729	DNA double-strand break processing	21325134.	IDA	Process
GO:0000731	DNA synthesis involved in DNA repair	21873635.	IBA	Process
GO:0000732	strand displacement	21873635.	IBA	Process
GO:0000733	DNA strand renaturation	-	IEA	Process
GO:0000781	chromosome, telomeric region	21873635.	IBA	Component
GO:0000781	chromosome, telomeric region	10779560.	IDA	Component
GO:0000800	lateral element	21873635.	IBA	Component
GO:0000800	lateral element	10728666.	IDA	Component
GO:0002039	p53 binding	21873635.	IBA	Function
GO:0002039	p53 binding	11781842.	IPI	Function
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003677	DNA binding	24816114.	IDA	Function
GO:0003678	DNA helicase activity	19734539.	IDA	Function
GO:0003697	single-stranded DNA binding	21873635.	IBA	Function
GO:0003697	single-stranded DNA binding	12818200.20639533.	IDA	Function
GO:0004003	ATP-dependent DNA helicase activity	9388193.24816114.25901030.	IDA	Function
GO:0004003	ATP-dependent DNA helicase activity	21325134.	IMP	Function
GO:0004386	helicase activity	10871376.12181313.17878217.	IDA	Function
GO:0005515	protein binding	10728666.10825162.11309417.11919194.12181313.12975363.14688284.15229185.15775963.15965237.16030011.16864798.17961633.20360068.20711169.20826342.21240188.21325134.23509288.23708797.24126761.26496610.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005524	ATP binding	17878217.24816114.25901030.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9388480.11500040.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005657	replication fork	21873635.	IBA	Component
GO:0005657	replication fork	-	ISS	Component
GO:0005694	chromosome	21873635.	IBA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	10779560.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006260	DNA replication	-	ISS	Process
GO:0006260	DNA replication	-	TAS	Process
GO:0006281	DNA repair	21873635.	IBA	Process
GO:0006281	DNA repair	7585968.	NAS	Process
GO:0006303	double-strand break repair via nonhomologous end joining	21873635.	IBA	Process
GO:0006310	DNA recombination	21873635.	IBA	Process
GO:0006310	DNA recombination	7585968.10728666.	NAS	Process
GO:0006974	cellular response to DNA damage stimulus	23509288.	IDA	Process
GO:0006974	cellular response to DNA damage stimulus	12818200.	IMP	Process
GO:0007095	mitotic G2 DNA damage checkpoint	21873635.	IBA	Process
GO:0007095	mitotic G2 DNA damage checkpoint	11309417.	IDA	Process
GO:0008026	ATP-dependent helicase activity	12818200.	IDA	Function
GO:0008094	DNA-dependent ATPase activity	24816114.25901030.	IDA	Function
GO:0008270	zinc ion binding	21873635.	IBA	Function
GO:0008270	zinc ion binding	24816114.25901030.	IDA	Function
GO:0009378	four-way junction helicase activity	21873635.	IBA	Function
GO:0009378	four-way junction helicase activity	11433031.11735402.12818200.25901030.	IDA	Function
GO:0010165	response to X-ray	21873635.	IBA	Process
GO:0010165	response to X-ray	11309417.	IDA	Process
GO:0010705	meiotic DNA double-strand break processing involved in reciprocal meiotic recombination	21873635.	IBA	Process
GO:0016363	nuclear matrix	21873635.	IBA	Component
GO:0016363	nuclear matrix	11309417.	IDA	Component
GO:0016605	PML body	21873635.	IBA	Component
GO:0016605	PML body	10728666.	IDA	Component
GO:0016605	PML body	10779560.	IDA	Component
GO:0016887	ATPase activity	17878217.	IDA	Function
GO:0031297	replication fork processing	21873635.	IBA	Process
GO:0031297	replication fork processing	17115688.	IDA	Process
GO:0032508	DNA duplex unwinding	21873635.	IBA	Process
GO:0032508	DNA duplex unwinding	11735402.24816114.25901030.	IDA	Process
GO:0036310	annealing helicase activity	21873635.	IBA	Function
GO:0036310	annealing helicase activity	17878217.	IDA	Function
GO:0042803	protein homodimerization activity	21873635.	IBA	Function
GO:0042803	protein homodimerization activity	28228481.	IDA	Function
GO:0043066	negative regulation of apoptotic process	21873635.	IBA	Process
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	21873635.	IBA	Function
GO:0044806	G-quadruplex DNA unwinding	21873635.	IBA	Process
GO:0044806	G-quadruplex DNA unwinding	11735402.	IDA	Process
GO:0044806	G-quadruplex DNA unwinding	-	ISS	Process
GO:0045003	double-strand break repair via synthesis-dependent strand annealing	21873635.	IBA	Process
GO:0045120	pronucleus	21873635.	IBA	Component
GO:0045893	positive regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0045893	positive regulation of transcription, DNA-templated	11781842.	IDA	Process
GO:0045910	negative regulation of DNA recombination	9671747.	IMP	Process
GO:0045950	negative regulation of mitotic recombination	21873635.	IBA	Process
GO:0046632	alpha-beta T cell differentiation	21873635.	IBA	Process
GO:0046641	positive regulation of alpha-beta T cell proliferation	21873635.	IBA	Process
GO:0048478	replication fork protection	10779560.	NAS	Process
GO:0051259	protein complex oligomerization	21873635.	IBA	Process
GO:0051259	protein complex oligomerization	10359700.28228481.	IDA	Process
GO:0051260	protein homooligomerization	21873635.	IBA	Process
GO:0051260	protein homooligomerization	28228481.	IDA	Process
GO:0051307	meiotic chromosome separation	21873635.	IBA	Process
GO:0051782	negative regulation of cell division	21873635.	IBA	Process
GO:0051782	negative regulation of cell division	11781842.	IMP	Process
GO:0051880	G-quadruplex DNA binding	11433031.11735402.	IDA	Function
GO:0061749	forked DNA-dependent helicase activity	21873635.	IBA	Function
GO:0061749	forked DNA-dependent helicase activity	11735402.25901030.	IDA	Function
GO:0061820	telomeric D-loop disassembly	21873635.	IBA	Process
GO:0061820	telomeric D-loop disassembly	19734539.	IDA	Process
GO:0061821	telomeric D-loop binding	21873635.	IBA	Function
GO:0061821	telomeric D-loop binding	19734539.	IDA	Function
GO:0061849	telomeric G-quadruplex DNA binding	19734539.	IC	Function
GO:0070244	negative regulation of thymocyte apoptotic process	21873635.	IBA	Process
GO:0071139	resolution of recombination intermediates	21873635.	IBA	Process
GO:0071479	cellular response to ionizing radiation	21873635.	IBA	Process
GO:0071479	cellular response to ionizing radiation	23509288.	IDA	Process
GO:0072711	cellular response to hydroxyurea	21873635.	IBA	Process
GO:0072711	cellular response to hydroxyurea	23509288.	IDA	Process
GO:0072757	cellular response to camptothecin	23509288.	IDA	Process
GO:0090329	regulation of DNA-dependent DNA replication	21873635.	IBA	Process
GO:0090329	regulation of DNA-dependent DNA replication	25901030.	IMP	Process
GO:0090656	t-circle formation	27918544.	TAS	Process
GO:1901291	negative regulation of double-strand break repair via single-strand annealing	21873635.	IBA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process
GO:1905168	positive regulation of double-strand break repair via homologous recombination	21873635.	IBA	Process
GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	21873635.	IBA	Function
GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	19734539.	IDA	Function

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.