EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22360506	Global histone modification pattern associated with recurrence and disease-free survival in non-small cell lung cancer patients.	Pathol Int	2012 Mar	Song JS	doi: 10.1111/j.1440-1827.2011.02776.x
16322686	Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins.	Cancer Biol Ther	2006 Jan	Tryndyak VP	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr12	14771099	5'UTR	rs765557544		0.33
BLCA	chr12	14770774	Nonstop_Mutation	novel	104Sext29	0.16
BLCA	chr12	14770730	3'UTR	rs773525610		0.12
BLCA	chr12	14770815	Silent	NA	A90A	0.54
BLCA	chr12	14771074	Missense_Mutation	NA	R4Q	0.09
BLCA	chr12	14771125	5'UTR	novel		0.26
BRCA	chr12	14770971	Silent	NA	L38L	0.23
BRCA	chr12	14771029	Missense_Mutation	NA	H19L	0.16
BRCA	chr12	14771111	5'UTR	novel		0.2
CESC	chr12	14770895	Missense_Mutation	novel	E64Q	0.31
CESC	chr12	14770812	Silent	NA	L91L	0.27
COAD	chr12	14770932	Silent	novel	I51I	0.23
COAD	chr12	14771000	Missense_Mutation	novel	G29C	0.14
COAD	chr12	14770969	Frame_Shift_Ins	novel	*A39Vfs30**	0.25
COAD	chr12	14770845	Missense_Mutation	novel	K80N	0.19
COAD	chr12	14770957	Frame_Shift_Del	novel	*G43Afs24**	0.42
COAD	chr12	14770946	Missense_Mutation	novel	I47V	0.17
DLBC	chr12	14770913	Missense_Mutation	novel	V58L	0.14
DLBC	chr12	14770686	3'UTR	novel		0.17
DLBC	chr12	14771018	Missense_Mutation	novel	L23M	0.21
DLBC	chr12	14770759	3'UTR	rs765530836		0.44
ESCA	chr12	14770909	Frame_Shift_Ins	novel	*L59Pfs11**	0.13
ESCA	chr12	14771058	Silent	rs755941297	K9K	0.08
GBM	chr12	14770827	Silent	rs759672780	D86D	0.13
GBM	chr12	14770891	Missense_Mutation	novel	N65T	0.18
GBM	chr12	14770936	Missense_Mutation	novel	L50R	0.21
GBM	chr12	14771080	Missense_Mutation	novel	S2Y	0.24
HNSC	chr12	14771105	5'UTR	novel		0.2
HNSC	chr12	14770928	Missense_Mutation	novel	E53K	0.32
HNSC	chr12	14770879	Missense_Mutation	novel	D69G	0.13
HNSC	chr12	14770730	3'UTR	novel		0.19
HNSC	chr12	14771116	5'UTR	rs374737130		0.26
HNSC	chr12	14770984	Missense_Mutation	novel	A34V	0.39
KIRC	chr12	14770860	Silent	NA	E75E	0.21
LUAD	chr12	14771099	5'UTR	rs765557544		0.22
LUAD	chr12	14770895	Nonsense_Mutation	novel	E64*	0.22
LUSC	chr12	14771125	5'UTR	novel		0.05
LUSC	chr12	14770786	Missense_Mutation	novel	G100A	0.49
LUSC	chr12	14771104	5'UTR	novel		0.31
OV	chr12	14770966	Missense_Mutation	NA	R40Q	0.47
OV	chr12	14770892	Missense_Mutation	novel	N65D	0.06
OV	chr12	14771098	5'UTR	novel		0.3
PCPG	chr12	14771102	5'UTR	rs367736902		0.23
READ	chr12	14770760	3'UTR	novel		0.2
SKCM	chr12	14771012	Missense_Mutation	NA	D25N	0.46
SKCM	chr12	14770870	Missense_Mutation	NA	T72I	0.14
SKCM	chr12	14770999	Missense_Mutation	NA	G29V	0.14
STAD	chr12	14770789	Frame_Shift_Ins	novel	*Y99Lfs32**	0.45
STAD	chr12	14771099	5'UTR	rs765557544		0.24
THCA	chr12	14771099	5'UTR	rs765557544		0.51
THCA	chr12	14771097	5'UTR	novel		0.33
UCEC	chr12	14771011	Missense_Mutation	rs750582464	D25G	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	DEL	0.0909	0.087189
DLBC	DEL	0.0833	0.11856
GBM	DEL	0.1005	0.0061973
LUAD	DEL	0.2054	1.5736e-06
MESO	DEL	0.0805	0.17495
PAAD	DEL	0.1304	0.0019175
READ	DEL	0.1515	0.064633
STAD	DEL	0.1451	0.00030002
THYM	AMP	0.0325	0.24554

Survival Analysis

Cancer	P-value	Q-value
STAD	0.031	Kaplan-Meier Survival Analysis
PRAD	0.039	Kaplan-Meier Survival Analysis
LUSC	0.022	Kaplan-Meier Survival Analysis
TGCT	0.02	Kaplan-Meier Survival Analysis
COAD	0.0062	Kaplan-Meier Survival Analysis
BLCA	0.0003	Kaplan-Meier Survival Analysis
READ	0.0044	Kaplan-Meier Survival Analysis
LAML	0.019	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000197837 (Gene tree)
Gene ID: 121504
Gene Symbol: HIST4H4
Alias: MGC24116
Full Name: histone cluster 4 H4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 3,133 bases
Position: chr12:14,767,999-14,771,131
Accession: 20510
RBP type: non-canonical RBP
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000358064	HIST4H4-201	1918	-	ENSP00000350767	103 (aa)	-	P62805
ENST00000540565	HIST4H4-205	577	-	-	- (aa)	-	-
ENST00000537096	HIST4H4-202	372	-	-	- (aa)	-	-
ENST00000537853	HIST4H4-203	448	-	-	- (aa)	-	-
ENST00000541592	HIST4H4-206	810	-	-	- (aa)	-	-
ENST00000539745	HIST4H4-204	577	-	ENSP00000443017	103 (aa)	-	P62805

Gene Model

Click here to download ENSG00000197837's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05034	Alcoholism	KEGG
hsa05203	Viral carcinogenesis	KEGG
hsa05322	Systemic lupus erythematosus	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197837's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197837	HIST4H4	100	99.029	WBGene00001941	his-67	100	99.029	Caenorhabditis_elegans
ENSG00000197837	HIST4H4	100	100.000	ENSG00000276180	HIST1H4I	100	100.000	Homo_sapiens
ENSG00000197837	HIST4H4	100	100.000	ENSG00000278705	HIST1H4B	100	100.000	Homo_sapiens
ENSG00000197837	HIST4H4	100	100.000	ENSG00000276966	HIST1H4E	100	100.000	Homo_sapiens
ENSG00000197837	HIST4H4	100	100.000	ENSG00000275126	HIST1H4L	100	100.000	Homo_sapiens
ENSG00000197837	HIST4H4	100	100.000	ENSG00000197061	HIST1H4C	100	100.000	Homo_sapiens
ENSG00000197837	HIST4H4	100	100.000	ENSG00000274618	HIST1H4F	100	100.000	Homo_sapiens
ENSG00000197837	HIST4H4	100	100.000	ENSG00000270882	HIST2H4A	100	100.000	Homo_sapiens
ENSG00000197837	HIST4H4	100	100.000	ENSG00000270276	HIST2H4B	100	100.000	Homo_sapiens
ENSG00000197837	HIST4H4	100	92.233	YBR009C		100	92.233	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000183	chromatin silencing at rDNA	-	TAS	Process
GO:0000228	nuclear chromosome	14718166.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000786	nucleosome	21636898.24699735.25615412.	IDA	Component
GO:0000786	nucleosome	3035717.	TAS	Component
GO:0000788	nuclear nucleosome	20498094.	IDA	Component
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003677	DNA binding	3035717.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	9540062.10220385.14585971.15161933.15933069.16415788.16917504.17540172.18404153.18408754.18474616.18571423.19410544.19494831.19498464.19710015.19862764.20000738.20224553.20498094.20618440.20709061.20739937.20951943.21085121.21478274.21596426.21743476.21888893.21983900.22343720.22368283.22373579.22615379.23071334.23075851.23142979.23377543.23760478.23831576.24183680.24360279.24361270.24525235.24596249.24726341.25281266.25416956.25556234.25579814.25619998.25651062.25910212.26167883.26496610.26912361.30021884.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	14585971.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	Process
GO:0006334	nucleosome assembly	21873635.	IBA	Process
GO:0006334	nucleosome assembly	20498094.21636898.24699735.25615412.	IDA	Process
GO:0006335	DNA replication-dependent nucleosome assembly	14718166.	IDA	Process
GO:0006336	DNA replication-independent nucleosome assembly	14718166.	IDA	Process
GO:0006352	DNA-templated transcription, initiation	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016233	telomere capping	-	TAS	Process
GO:0019904	protein domain specific binding	22368283.	IPI	Function
GO:0032200	telomere organization	17675446.	TAS	Process
GO:0032991	protein-containing complex	14718166.	IDA	Component
GO:0034080	CENP-A containing nucleosome assembly	-	TAS	Process
GO:0044267	cellular protein metabolic process	-	TAS	Process
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0045653	negative regulation of megakaryocyte differentiation	18474616.	IDA	Process
GO:0045814	negative regulation of gene expression, epigenetic	-	TAS	Process
GO:0046982	protein heterodimerization activity	-	IEA	Function
GO:0051290	protein heterotetramerization	20498094.	IDA	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0070062	extracellular exosome	19199708.20458337.23533145.	HDA	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.