EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22360506Global histone modification pattern associated with recurrence and disease-free survival in non-small cell lung cancer patients.Pathol Int2012 MarSong JSdoi: 10.1111/j.1440-1827.2011.02776.x
16322686Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins.Cancer Biol Ther2006 JanTryndyak VP-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr12147710995'UTRrs7655575440.33
BLCAchr1214770774Nonstop_Mutationnovel*104Sext*290.16
BLCAchr12147707303'UTRrs7735256100.12
BLCAchr1214770815SilentNAA90A0.54
BLCAchr1214771074Missense_MutationNAR4Q0.09
BLCAchr12147711255'UTRnovel0.26
BRCAchr1214770971SilentNAL38L0.23
BRCAchr1214771029Missense_MutationNAH19L0.16
BRCAchr12147711115'UTRnovel0.2
CESCchr1214770895Missense_MutationnovelE64Q0.31
CESCchr1214770812SilentNAL91L0.27
COADchr1214770932SilentnovelI51I0.23
COADchr1214771000Missense_MutationnovelG29C0.14
COADchr1214770969Frame_Shift_InsnovelA39Vfs*300.25
COADchr1214770845Missense_MutationnovelK80N0.19
COADchr1214770957Frame_Shift_DelnovelG43Afs*240.42
COADchr1214770946Missense_MutationnovelI47V0.17
DLBCchr1214770913Missense_MutationnovelV58L0.14
DLBCchr12147706863'UTRnovel0.17
DLBCchr1214771018Missense_MutationnovelL23M0.21
DLBCchr12147707593'UTRrs7655308360.44
ESCAchr1214770909Frame_Shift_InsnovelL59Pfs*110.13
ESCAchr1214771058Silentrs755941297K9K0.08
GBMchr1214770827Silentrs759672780D86D0.13
GBMchr1214770891Missense_MutationnovelN65T0.18
GBMchr1214770936Missense_MutationnovelL50R0.21
GBMchr1214771080Missense_MutationnovelS2Y0.24
HNSCchr12147711055'UTRnovel0.2
HNSCchr1214770928Missense_MutationnovelE53K0.32
HNSCchr1214770879Missense_MutationnovelD69G0.13
HNSCchr12147707303'UTRnovel0.19
HNSCchr12147711165'UTRrs3747371300.26
HNSCchr1214770984Missense_MutationnovelA34V0.39
KIRCchr1214770860SilentNAE75E0.21
LUADchr12147710995'UTRrs7655575440.22
LUADchr1214770895Nonsense_MutationnovelE64*0.22
LUSCchr12147711255'UTRnovel0.05
LUSCchr1214770786Missense_MutationnovelG100A0.49
LUSCchr12147711045'UTRnovel0.31
OVchr1214770966Missense_MutationNAR40Q0.47
OVchr1214770892Missense_MutationnovelN65D0.06
OVchr12147710985'UTRnovel0.3
PCPGchr12147711025'UTRrs3677369020.23
READchr12147707603'UTRnovel0.2
SKCMchr1214771012Missense_MutationNAD25N0.46
SKCMchr1214770870Missense_MutationNAT72I0.14
SKCMchr1214770999Missense_MutationNAG29V0.14
STADchr1214770789Frame_Shift_InsnovelY99Lfs*320.45
STADchr12147710995'UTRrs7655575440.24
THCAchr12147710995'UTRrs7655575440.51
THCAchr12147710975'UTRnovel0.33
UCECchr1214771011Missense_Mutationrs750582464D25G0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
COADDEL0.09090.087189
DLBCDEL0.08330.11856
GBMDEL0.10050.0061973
LUADDEL0.20541.5736e-06
MESODEL0.08050.17495
PAADDEL0.13040.0019175
READDEL0.15150.064633
STADDEL0.14510.00030002
THYMAMP0.03250.24554

Survival Analysis
CancerP-value Q-value
STAD0.031

Kaplan-Meier Survival Analysis

PRAD0.039

Kaplan-Meier Survival Analysis

LUSC0.022

Kaplan-Meier Survival Analysis

TGCT0.02

Kaplan-Meier Survival Analysis

COAD0.0062

Kaplan-Meier Survival Analysis

BLCA0.0003

Kaplan-Meier Survival Analysis

READ0.0044

Kaplan-Meier Survival Analysis

LAML0.019

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000197837 (Gene tree)
Gene ID
121504
Gene Symbol
HIST4H4
Alias
MGC24116
Full Name
histone cluster 4 H4
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
3,133 bases
Position
chr12:14,767,999-14,771,131
Accession
20510
RBP type
non-canonical RBP
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000358064HIST4H4-2011918-ENSP00000350767103 (aa)-P62805
ENST00000540565HIST4H4-205577--- (aa)--
ENST00000537096HIST4H4-202372--- (aa)--
ENST00000537853HIST4H4-203448--- (aa)--
ENST00000541592HIST4H4-206810--- (aa)--
ENST00000539745HIST4H4-204577-ENSP00000443017103 (aa)-P62805
Gene Model
Click here to download ENSG00000197837's gene model file
Pathways
Pathway IDPathway NameSource
hsa05034AlcoholismKEGG
hsa05203Viral carcinogenesisKEGG
hsa05322Systemic lupus erythematosusKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197837's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000197837HIST4H410099.029WBGene00001941his-6710099.029Caenorhabditis_elegans
ENSG00000197837HIST4H4100100.000ENSG00000276180HIST1H4I100100.000Homo_sapiens
ENSG00000197837HIST4H4100100.000ENSG00000278705HIST1H4B100100.000Homo_sapiens
ENSG00000197837HIST4H4100100.000ENSG00000276966HIST1H4E100100.000Homo_sapiens
ENSG00000197837HIST4H4100100.000ENSG00000275126HIST1H4L100100.000Homo_sapiens
ENSG00000197837HIST4H4100100.000ENSG00000197061HIST1H4C100100.000Homo_sapiens
ENSG00000197837HIST4H4100100.000ENSG00000274618HIST1H4F100100.000Homo_sapiens
ENSG00000197837HIST4H4100100.000ENSG00000270882HIST2H4A100100.000Homo_sapiens
ENSG00000197837HIST4H4100100.000ENSG00000270276HIST2H4B100100.000Homo_sapiens
ENSG00000197837HIST4H410092.233YBR009C10092.233Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000183chromatin silencing at rDNA-TASProcess
GO:0000228nuclear chromosome14718166.IDAComponent
GO:0000784nuclear chromosome, telomeric region19135898.HDAComponent
GO:0000786nucleosome21636898.24699735.25615412.IDAComponent
GO:0000786nucleosome3035717.TASComponent
GO:0000788nuclear nucleosome20498094.IDAComponent
GO:0003677DNA binding21873635.IBAFunction
GO:0003677DNA binding3035717.TASFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding9540062.10220385.14585971.15161933.15933069.16415788.16917504.17540172.18404153.18408754.18474616.18571423.19410544.19494831.19498464.19710015.19862764.20000738.20224553.20498094.20618440.20709061.20739937.20951943.21085121.21478274.21596426.21743476.21888893.21983900.22343720.22368283.22373579.22615379.23071334.23075851.23142979.23377543.23760478.23831576.24183680.24360279.24361270.24525235.24596249.24726341.25281266.25416956.25556234.25579814.25619998.25651062.25910212.26167883.26496610.26912361.30021884.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005634nucleus21630459.HDAComponent
GO:0005634nucleus14585971.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0006303double-strand break repair via nonhomologous end joining-TASProcess
GO:0006334nucleosome assembly21873635.IBAProcess
GO:0006334nucleosome assembly20498094.21636898.24699735.25615412.IDAProcess
GO:0006335DNA replication-dependent nucleosome assembly14718166.IDAProcess
GO:0006336DNA replication-independent nucleosome assembly14718166.IDAProcess
GO:0006352DNA-templated transcription, initiation-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016233telomere capping-TASProcess
GO:0019904protein domain specific binding22368283.IPIFunction
GO:0032200telomere organization17675446.TASProcess
GO:0032991protein-containing complex14718166.IDAComponent
GO:0034080CENP-A containing nucleosome assembly-TASProcess
GO:0044267cellular protein metabolic process-TASProcess
GO:0045652regulation of megakaryocyte differentiation-TASProcess
GO:0045653negative regulation of megakaryocyte differentiation18474616.IDAProcess
GO:0045814negative regulation of gene expression, epigenetic-TASProcess
GO:0046982protein heterodimerization activity-IEAFunction
GO:0051290protein heterotetramerization20498094.IDAProcess
GO:0060964regulation of gene silencing by miRNA-TASProcess
GO:0070062extracellular exosome19199708.20458337.23533145.HDAComponent
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us