EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25315189	The high-mobility group nucleosome-binding domain 5 is highly expressed in breast cancer and promotes the proliferation and invasion of breast cancer cells.	Tumour Biol	2015 Feb	Weng M	doi: 10.1007/s13277-014-2715-1
25307178	HMGN5 knockdown sensitizes prostate cancer cells to ionizing radiation.	Prostate	2015 Jan	Su B	doi: 10.1002/pros.22888
22504871	Small interfering RNA targeting HMGN5 induces apoptosis via modulation of a mitochondrial pathway and Bcl-2 family proteins in prostate cancer cells.	Asian J Androl	2012 May	Zhang XY	doi: 10.1038/aja.2012.18
26394192	microRNA-340 Suppresses Tumorigenic Potential of Prostate Cancer Cells by Targeting High-Mobility Group Nucleosome-Binding Domain 5.	DNA Cell Biol	2016 Jan	Wei P	doi: 10.1089/dna.2015.3021
25796505	Knockdown of HMGN5 suppresses the viability and invasion of human urothelial bladder cancer 5637 cells in vitro and in vivo.	Med Oncol	2015 Apr	Gan Y	doi: 10.1007/s12032-015-0594-y
21695596	The nucleosome binding protein NSBP1 is highly expressed in human bladder cancer and promotes the proliferation and invasion of bladder cancer cells.	Tumour Biol	2011 Oct	Wahafu W	doi: 10.1007/s13277-011-0195-0
25572120	Expression of oncogenic HMGN5 increases the sensitivity of prostate cancer cells to gemcitabine.	Oncol Rep	2015 Mar	Guo Z	doi: 10.3892/or.2014.3696

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chrX	81121616	5'UTR	novel		0.3
BLCA	chrX	81118436	Missense_Mutation	novel	S42L	0.21
BRCA	chrX	81114954	Missense_Mutation	NA	G182R	0.8
BRCA	chrX	81116239	Nonsense_Mutation	NA	E78*	0.13
BRCA	chrX	81115090	Missense_Mutation	novel	D136E	0.08
BRCA	chrX	81121595	5'UTR	rs775506639		0.19
BRCA	chrX	81116291	Silent	NA	A60A	0.19
BRCA	chrX	81121532	Splice_Region	novel		0.19
BRCA	chrX	81115169	Missense_Mutation	NA	E110A	0.41
BRCA	chrX	81116291	Silent	NA	A60A	0.06
BRCA	chrX	81114596	3'UTR	novel		0.23
BRCA	chrX	81116291	Silent	NA	A60A	0.05
BRCA	chrX	81113750	3'UTR	novel		0.3
BRCA	chrX	81121658	5'UTR	novel		0.18
CESC	chrX	81118436	Nonsense_Mutation	novel	S42*	0.08
CESC	chrX	81121568	5'UTR	novel		0.34
CESC	chrX	81114861	Missense_Mutation	rs777711096	D213N	0.22
COAD	chrX	81115123	Frame_Shift_Ins	NA	*N125Kfs2**	0.33
COAD	chrX	81114430	3'UTR	novel		0.33
COAD	chrX	81114964	Frame_Shift_Del	NA	*G179Vfs48**	0.75
COAD	chrX	81114964	Frame_Shift_Del	NA	*G179Vfs48**	0.23
COAD	chrX	81118448	Missense_Mutation	NA	R38I	0.36
ESCA	chrX	81116291	Silent	NA	A60A	0.17
ESCA	chrX	81116312	Missense_Mutation	novel	E53D	0.29
GBM	chrX	81115194	Nonsense_Mutation	novel	E102*	1
HNSC	chrX	81121577	5'UTR	novel		0.29
HNSC	chrX	81121599	5'UTR	novel		0.6
HNSC	chrX	81118757	Splice_Region	novel	P16P	0.32
KIRC	chrX	81114915	Missense_Mutation	novel	D195N	0.08
KIRC	chrX	81121627	5'UTR	novel		0.7
LIHC	chrX	81115164	Nonsense_Mutation	novel	G112*	0.48
LIHC	chrX	81121658	5'UTR	novel		0.48
LUAD	chrX	81121561	5'UTR	novel		0.63
LUAD	chrX	81115144	Silent	novel	A118A	0.36
LUAD	chrX	81121547	Translation_Start_Site	novel	M1?	0.24
LUAD	chrX	81121662	5'UTR	novel		0.4
LUAD	chrX	81119803	Silent	NA	G10G	0.08
LUAD	chrX	81119805	Missense_Mutation	novel	G10C	0.36
OV	chrX	81114964	Frame_Shift_Del	NA	*G179Vfs48**	0.23
READ	chrX	81115083	Missense_Mutation	novel	E139K	1
SARC	chrX	81116291	Silent	NA	A60A	0.1
SKCM	chrX	81119812	Silent	NA	A7A	0.2
SKCM	chrX	81115191	Missense_Mutation	NA	E103K	0.55
SKCM	chrX	81121567	5'UTR	novel		0.18
SKCM	chrX	81116323	Missense_Mutation	rs764982112	D50N	0.25
SKCM	chrX	81121619	5'UTR	novel		0.67
UCEC	chrX	81115186	Frame_Shift_Ins	novel	*N104Kfs3**	0.42
UCEC	chrX	81116311	Nonsense_Mutation	NA	E54*	0.34
UCEC	chrX	81114683	Missense_Mutation	novel	D272G	0.11
UCEC	chrX	81114893	Missense_Mutation	NA	R202I	0.27
UCEC	chrX	81115191	Nonsense_Mutation	novel	E103*	0.15
UCEC	chrX	81114954	Missense_Mutation	NA	G182R	0.21
UCEC	chrX	81114501	3'UTR	novel		0.43
UCEC	chrX	81114825	Missense_Mutation	NA	D225Y	0.39
UCEC	chrX	81116315	Missense_Mutation	novel	M52I	0.53
UCEC	chrX	81115140	Missense_Mutation	novel	A120T	0.2
UCEC	chrX	81114721	Missense_Mutation	novel	E259D	0.38
UCEC	chrX	81114810	Nonsense_Mutation	novel	E230*	0.37
UCEC	chrX	81114340	3'UTR	novel		0.27
UCEC	chrX	81115009	Silent	novel	G163G	0.35
UCEC	chrX	81114429	3'UTR	novel		0.43
UCEC	chrX	81115139	Missense_Mutation	novel	A120V	0.43
UCEC	chrX	81114452	3'UTR	novel		0.48
UCEC	chrX	81114661	Silent	novel	Q279Q	0.41
UCEC	chrX	81114565	3'UTR	novel		0.25
UCEC	chrX	81118456	Silent	novel	K35K	0.39
UCEC	chrX	81121547	Translation_Start_Site	novel	M1?	0.44
UCEC	chrX	81114542	3'UTR	novel		0.36
UCEC	chrX	81114888	Nonsense_Mutation	novel	E204*	0.31
UCEC	chrX	81114750	Missense_Mutation	novel	G250R	0.32
UCEC	chrX	81114437	3'UTR	novel		0.17
UCEC	chrX	81114712	Silent	novel	G262G	0.41
UCEC	chrX	81114875	Missense_Mutation	novel	G208V	0.17
UCEC	chrX	81115191	Nonsense_Mutation	novel	E103*	0.38
UCEC	chrX	81114694	Silent	novel	I268I	0.37
UCEC	chrX	81121584	5'UTR	novel		0.37
UCEC	chrX	81116291	Silent	NA	A60A	0.08
UCEC	chrX	81114376	3'UTR	novel		0.4
UCEC	chrX	81114835	Frame_Shift_Del	novel	*E222Rfs5**	0.45
UCEC	chrX	81116291	Silent	NA	A60A	0.07
UCEC	chrX	81114818	Missense_Mutation	novel	K227T	0.19
UCEC	chrX	81116291	Silent	NA	A60A	0.12
UCEC	chrX	81116326	In_Frame_Ins	novel	K48_S49insFPFKL	0.05
UCEC	chrX	81115094	Missense_Mutation	NA	E135G	0.15
UCEC	chrX	81114750	Frame_Shift_Ins	novel	*G250Wfs18**	0.25
UCEC	chrX	81114752	Missense_Mutation	novel	A249D	0.25
UCEC	chrX	81114476	3'UTR	novel		0.43
UCEC	chrX	81114437	3'UTR	novel		0.4
UCEC	chrX	81114742	Missense_Mutation	NA	E252D	0.31
UCEC	chrX	81116291	Silent	NA	A60A	0.1
UCEC	chrX	81116280	Missense_Mutation	novel	A64V	0.26
UCEC	chrX	81118746	Missense_Mutation	NA	S20Y	0.06
UCEC	chrX	81114532	3'UTR	novel		0.32
UCEC	chrX	81114558	3'UTR	novel		0.24

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
THCA	DEL	0	0.21991

Survival Analysis

Cancer	P-value	Q-value
SARC	0.044	Kaplan-Meier Survival Analysis
MESO	0.00011	Kaplan-Meier Survival Analysis
ACC	0.011	Kaplan-Meier Survival Analysis
BRCA	0.016	Kaplan-Meier Survival Analysis
PAAD	0.00032	Kaplan-Meier Survival Analysis
READ	0.037	Kaplan-Meier Survival Analysis
DLBC	0.04	Kaplan-Meier Survival Analysis
OV	0.0002	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000198157 (Gene tree)
Gene ID: 79366
Gene Symbol: HMGN5
Alias: NSBP1
Full Name: high mobility group nucleosome binding domain 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 88,242 bases
Position: chrX:81,113,701-81,201,942
Accession: 8013
RBP type: non-canonical RBP
Summary: This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30377405	Loss of high-mobility group N5 contributes to the promotion of human endometrial stromal cell decidualization.	Reprod Med Biol	2018 Aug 16	Kimura M	doi: 10.1002/rmb2.12226
20531280	Downregulation of the nucleosome-binding protein 1 (NSBP1) gene can inhibit the in vitro and in vivo proliferation of prostate cancer cells.	Asian J Androl	2010 Sep	Jiang N	doi: 10.1038/aja.2010.39

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000447319	HMGN5-205	742	-	ENSP00000408060	201 (aa)	-	Q5JSK9
ENST00000373250	HMGN5-202	572	-	ENSP00000362347	161 (aa)	-	Q5JSK6
ENST00000451455	HMGN5-206	720	-	ENSP00000404810	89 (aa)	-	Q5JSK7
ENST00000430960	HMGN5-203	578	-	ENSP00000399626	148 (aa)	-	Q5JSL0
ENST00000491275	HMGN5-207	547	-	-	- (aa)	-	-
ENST00000358130	HMGN5-201	2126	-	ENSP00000350848	282 (aa)	-	P82970
ENST00000436386	HMGN5-204	859	-	ENSP00000413402	102 (aa)	-	Q5JSK8

Gene Model

Click here to download ENSG00000198157's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198157's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000785	chromatin	-	IEA	Component
GO:0003682	chromatin binding	11161810.	NAS	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005634	nucleus	11161810.	NAS	Component
GO:0006325	chromatin organization	-	IEA	Process
GO:0006355	regulation of transcription, DNA-templated	11161810.	NAS	Process
GO:0008284	positive regulation of cell proliferation	20531280.	IMP	Process
GO:0010628	positive regulation of gene expression	20531280.	IMP	Process
GO:0031492	nucleosomal DNA binding	-	IEA	Function
GO:0043066	negative regulation of apoptotic process	20531280.	IMP	Process
GO:0045893	positive regulation of transcription, DNA-templated	11161810.	NAS	Process
GO:0071157	negative regulation of cell cycle arrest	20531280.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.