EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17020779	Prognostic value of humbug gene overexpression in stage II colon cancer.	Hum Pathol	2007 Jan	Wang J	-
16673309	Detection of human aspartyl (asparaginyl) beta-hydroxylase and homeobox B7 mRNA in brush cytology specimens from patients with bile duct cancer.	Endoscopy	2006 Jun	Feldmann G	-
19200576	Prognostic value of aspartyl (asparaginyl)-beta-hydroxylase/humbug expression in non-small cell lung carcinoma.	Hum Pathol	2009 May	Luu M	doi: 10.1016/j.humpath.2008.11.001
18288418	Overexpression of humbug promotes malignant progression in human gastric cancer cells.	Oncol Rep	2008 Mar	Lee JH	-
29737090	[Expression of ASPH Gene in Invasive Breast Cancer and Its Clinical Significance in Promoter Methylation].	Sichuan Da Xue Xue Bao Yi Xue Ban	2018 Jan	Li C	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr8	61684053	Missense_Mutation	rs768498732	Y80C	0.19
BLCA	chr8	61676203	Intron	rs371484854		0.52
BLCA	chr8	61682453	Intron	novel		0.61
BLCA	chr8	61578504	Intron	novel		0.09
BLCA	chr8	61651110	Missense_Mutation	rs758840739	E144K	0.44
BLCA	chr8	61680989	Missense_Mutation	novel	D101N	0.18
BLCA	chr8	61526020	Silent	NA	L619L	0.12
BLCA	chr8	61646823	Silent	rs777861394	E182E	0.07
BLCA	chr8	61578724	Intron	novel		0.72
BLCA	chr8	61578389	Intron	novel		0.15
BLCA	chr8	61553033	Missense_Mutation	novel	E542K	0.32
BLCA	chr8	61578763	Intron	novel		0.19
BLCA	chr8	61579135	Intron	novel		0.16
BRCA	chr8	61643410	Missense_Mutation	NA	D245N	0.22
BRCA	chr8	61676313	Intron	NA		0.28
BRCA	chr8	61548134	Silent	NA	V567V	0.31
BRCA	chr8	61578661	Intron	novel		0.49
BRCA	chr8	61579353	Intron	novel		0.2
BRCA	chr8	61653600	Frame_Shift_Del	novel	*H127Lfs65**	0.1
BRCA	chr8	61651082	Missense_Mutation	NA	S153C	0.23
BRCA	chr8	61579104	Intron	novel		0.32
BRCA	chr8	61664907	Intron	novel		0.21
BRCA	chr8	61579488	Intron	novel		0.05
BRCA	chr8	61665528	Intron	novel		0.08
BRCA	chr8	61579363	Intron	novel		0.12
BRCA	chr8	61578696	Intron	novel		0.21
BRCA	chr8	61626089	Intron	novel		0.23
BRCA	chr8	61518112	Nonsense_Mutation	NA	E638*	0.14
BRCA	chr8	61567175	Missense_Mutation	NA	Q431H	0.21
BRCA	chr8	61646823	Missense_Mutation	NA	E182D	0.12
BRCA	chr8	61503366	Missense_Mutation	novel	A757G	0.08
CESC	chr8	61653645	Missense_Mutation	NA	S113C	0.21
CESC	chr8	61579092	Intron	novel		0.07
CESC	chr8	61633725	Missense_Mutation	NA	V298L	0.32
CESC	chr8	61553102	Missense_Mutation	novel	D519N	0.4
CESC	chr8	61689737	Intron	novel		0.23
CESC	chr8	61579055	Intron	novel		0.09
CESC	chr8	61576825	Nonsense_Mutation	novel	E366*	0.35
CESC	chr8	61583978	Missense_Mutation	novel	A343V	0.35
CESC	chr8	61618979	Missense_Mutation	novel	K325N	0.45
CESC	chr8	61665336	Intron	rs775462385		0.39
CESC	chr8	61518070	Missense_Mutation	rs140478604	E652K	0.28
CESC	chr8	61624760	Intron	novel		0.24
CESC	chr8	61503485	Silent	NA	L717L	0.31
CESC	chr8	61562797	Missense_Mutation	rs200072789	V462M	0.29
CESC	chr8	61553033	Missense_Mutation	NA	E542Q	0.28
CESC	chr8	61578628	Intron	novel		0.45
COAD	chr8	61548191	Silent	NA	E548E	0.43
COAD	chr8	61646785	Missense_Mutation	NA	R195K	0.12
COAD	chr8	61626217	Intron	novel		0.26
COAD	chr8	61633714	Frame_Shift_Del	novel	*P302Lfs33**	0.27
COAD	chr8	61665255	Intron	novel		0.29
COAD	chr8	61665507	Intron	novel		0.36
COAD	chr8	61665530	Intron	novel		0.07
COAD	chr8	61689737	Intron	novel		0.44
COAD	chr8	61689737	Intron	novel		0.57
COAD	chr8	61689737	Intron	novel		0.3
COAD	chr8	61682466	Intron	rs773300902		0.2
COAD	chr8	61583995	Missense_Mutation	rs746450205	F337L	0.31
COAD	chr8	61578629	Intron	novel		0.4
COAD	chr8	61503277	3'UTR	novel		0.55
COAD	chr8	61578732	Intron	novel		0.34
COAD	chr8	61684150	Missense_Mutation	novel	G48R	0.33
COAD	chr8	61689737	Intron	novel		0.16
COAD	chr8	61579239	Intron	novel		0.59
COAD	chr8	61633713	Frame_Shift_Ins	NA	*P302Sfs14**	0.37
COAD	chr8	61562798	Silent	rs753353393	G461G	0.26
COAD	chr8	61578707	Intron	novel		0.23
COAD	chr8	61633699	Silent	novel	Q306Q	0.17
COAD	chr8	61665235	Intron	novel		0.04
COAD	chr8	61689737	Intron	novel		0.63
COAD	chr8	61626127	Intron	novel		0.2
COAD	chr8	61665425	Intron	NA		0.16
COAD	chr8	61689697	Intron	novel		0.26
COAD	chr8	61689737	Intron	novel		0.23
COAD	chr8	61553105	Missense_Mutation	NA	G518R	0.25
COAD	chr8	61579469	Intron	novel		0.55
COAD	chr8	61684184	Frame_Shift_Del	NA	*T36Kfs40**	0.38
COAD	chr8	61567298	Silent	NA	E390E	0.4
COAD	chr8	61584025	Missense_Mutation	NA	K327N	0.37
COAD	chr8	61638331	Nonsense_Mutation	NA	E275*	0.18
COAD	chr8	61689737	Intron	novel		0.27
COAD	chr8	61555981	Missense_Mutation	novel	H493Q	0.25
COAD	chr8	61651100	Missense_Mutation	NA	A147V	0.09
DLBC	chr8	61517535	Missense_Mutation	rs755727749	E707K	0.17
ESCA	chr8	61579086	Intron	novel		0.25
ESCA	chr8	61579411	Intron	novel		0.06
ESCA	chr8	61579413	Intron	novel		0.05
ESCA	chr8	61579531	Intron	NA		0.11
ESCA	chr8	61646810	Missense_Mutation	novel	L187V	0.19
ESCA	chr8	61579531	Intron	NA		0.06
ESCA	chr8	61579531	Intron	NA		0.05
ESCA	chr8	61578618	Intron	NA		0.26
ESCA	chr8	61578618	Intron	NA		0.16
ESCA	chr8	61665344	Intron	novel		0.29
ESCA	chr8	61579552	Intron	novel		0.25
ESCA	chr8	61578326	Intron	novel		0.38
GBM	chr8	61579306	Intron	novel		0.17
GBM	chr8	61651101	Missense_Mutation	novel	A147S	0.06
GBM	chr8	61503506	Silent	novel	T710T	0.28
GBM	chr8	61548097	Nonsense_Mutation	novel	E580*	0.04
GBM	chr8	61578792	Intron	novel		0.05
HNSC	chr8	61517647	Silent	novel	I669I	0.26
HNSC	chr8	61642891	Nonsense_Mutation	novel	Q263*	0.53
HNSC	chr8	61633721	Missense_Mutation	rs111708484	S299N	0.11
HNSC	chr8	61665406	Intron	novel		0.36
HNSC	chr8	61526028	Missense_Mutation	novel	E617K	0.3
HNSC	chr8	61578726	Intron	novel		0.19
HNSC	chr8	61665279	Intron	rs145678786		0.3
HNSC	chr8	61526007	Missense_Mutation	novel	D624N	0.11
HNSC	chr8	61503466	Missense_Mutation	novel	E724Q	0.28
HNSC	chr8	61583972	Missense_Mutation	novel	L345H	0.22
HNSC	chr8	61578460	Intron	novel		0.13
HNSC	chr8	61653624	Missense_Mutation	rs773407540	P120L	0.2
HNSC	chr8	61689705	Intron	novel		0.15
HNSC	chr8	61518053	Silent	novel	T657T	0.06
HNSC	chr8	61526008	Silent	novel	G623G	0.42
HNSC	chr8	61562829	Missense_Mutation	novel	P451L	0.18
HNSC	chr8	61643980	Missense_Mutation	novel	D225A	0.27
KIRC	chr8	61665220	Intron	novel		0.36
KIRC	chr8	61676268	Intron	NA		0.21
KIRC	chr8	61665374	Intron	novel		0.03
KIRP	chr8	61578688	Intron	novel		0.24
KIRP	chr8	61643964	Missense_Mutation	novel	M230I	0.47
KIRP	chr8	61579336	Intron	novel		0.35
KIRP	chr8	61576808	Nonsense_Mutation	novel	Y371*	0.04
KIRP	chr8	61548191	Silent	NA	E548E	0.4
KIRP	chr8	61665175	Intron	novel		0.41
KIRP	chr8	61578433	Intron	novel		0.32
KIRP	chr8	61578508	Intron	novel		0.55
LAML	chr8	61576835	Missense_Mutation	novel	N362K	0.12
LGG	chr8	61643993	Missense_Mutation	novel	D221Y	0.24
LGG	chr8	61548150	Missense_Mutation	rs771474720	R562H	0.36
LGG	chr8	61562827	Missense_Mutation	novel	N452D	0.33
LGG	chr8	61579519	Intron	novel		0.45
LGG	chr8	61651060	Silent	rs759403041	H160H	0.35
LIHC	chr8	61578254	Intron	novel		0.43
LIHC	chr8	61562751	Missense_Mutation	NA	Y477F	0.13
LIHC	chr8	61681024	Missense_Mutation	NA	I89T	0.3
LIHC	chr8	61503219	3'UTR	novel		0.33
LIHC	chr8	61689737	Intron	novel		0.15
LUAD	chr8	61578599	Intron	novel		0.52
LUAD	chr8	61637978	Silent	NA	N286N	0.08
LUAD	chr8	61665236	Intron	novel		0.32
LUAD	chr8	61680989	Missense_Mutation	novel	D101Y	0.16
LUAD	chr8	61665374	Intron	novel		0.06
LUAD	chr8	61578651	Intron	novel		0.06
LUAD	chr8	61562783	Missense_Mutation	novel	L466F	0.17
LUAD	chr8	61689783	Intron	novel		0.4
LUAD	chr8	61578385	Intron	novel		0.11
LUAD	chr8	61553049	Missense_Mutation	novel	Q536H	0.04
LUAD	chr8	61517636	Missense_Mutation	novel	G673V	0.28
LUAD	chr8	61517620	Silent	rs368974538	P678P	0.09
LUAD	chr8	61578702	Intron	novel		0.22
LUAD	chr8	61665581	Intron	novel		0.21
LUAD	chr8	61684102	Missense_Mutation	novel	L64V	0.23
LUAD	chr8	61579652	Intron	novel		0.11
LUAD	chr8	61578528	Intron	novel		0.19
LUAD	chr8	61526084	Missense_Mutation	NA	R598L	0.25
LUAD	chr8	61553105	Nonsense_Mutation	novel	G518*	0.25
LUSC	chr8	61503339	3'UTR	novel		0.35
LUSC	chr8	61684088	Silent	novel	T68T	0.25
LUSC	chr8	61578946	Intron	novel		0.41
LUSC	chr8	61517563	Silent	NA	K697K	0.39
LUSC	chr8	61642901	Silent	rs760719359	V259V	0.23
LUSC	chr8	61676182	Intron	novel		0.14
LUSC	chr8	61548177	Missense_Mutation	novel	R553K	0.21
LUSC	chr8	61665101	Intron	novel		0.59
LUSC	chr8	61548180	Missense_Mutation	novel	K552R	0.32
LUSC	chr8	61638005	Splice_Region	novel		0.08
LUSC	chr8	61684190	Splice_Region	novel		0.11
LUSC	chr8	61567272	Missense_Mutation	NA	R399L	0.2
LUSC	chr8	61579531	Intron	NA		0.1
LUSC	chr8	61578976	Intron	novel		0.14
LUSC	chr8	61518062	Silent	NA	F654F	0.38
LUSC	chr8	61562817	Missense_Mutation	NA	S455F	0.29
LUSC	chr8	61578463	Intron	novel		0.44
LUSC	chr8	61518104	Silent	novel	A640A	0.37
LUSC	chr8	61643984	Nonsense_Mutation	NA	Q224*	0.31
LUSC	chr8	61665472	Intron	novel		0.43
LUSC	chr8	61562795	Silent	novel	V462V	0.35
LUSC	chr8	61553080	Missense_Mutation	novel	R526T	0.03
LUSC	chr8	61675969	Intron	novel		0.15
LUSC	chr8	61525991	Missense_Mutation	rs199833011	T629M	0.29
LUSC	chr8	61676062	Intron	novel		0.22
MESO	chr8	61626254	Intron	novel		0.38
OV	chr8	61579303	Intron	novel		0.09
OV	chr8	61576792	Missense_Mutation	NA	A377P	0.47
OV	chr8	61579183	Intron	novel		0.52
OV	chr8	61578883	Intron	novel		0.2
OV	chr8	61643389	Missense_Mutation	NA	T252P	0.13
OV	chr8	61689726	Intron	rs202115146		0.14
OV	chr8	61638005	Splice_Site	novel	X278_splice	0.25
OV	chr8	61579618	Intron	novel		0.29
OV	chr8	61526011	Silent	novel	K622K	0.14
PAAD	chr8	61548098	Missense_Mutation	NA	K579N	0.2
PAAD	chr8	61553052	Missense_Mutation	rs754531033	M535I	0.18
PCPG	chr8	61684125	Missense_Mutation	rs149440176	T56M	0.08
PRAD	chr8	61626212	Intron	novel		0.27
PRAD	chr8	61579289	Intron	novel		0.2
PRAD	chr8	61576776	Missense_Mutation	rs749737562	A382V	0.39
PRAD	chr8	61517628	Missense_Mutation	rs745483367	V676M	0.34
PRAD	chr8	61579333	Intron	novel		0.06
READ	chr8	61643948	Missense_Mutation	NA	P236S	0.23
READ	chr8	61578950	Intron	novel		0.07
READ	chr8	61517536	Silent	rs554349058	N706N	0.55
READ	chr8	61503418	Missense_Mutation	rs762826838	V740M	0.4
READ	chr8	61583999	Missense_Mutation	novel	K336T	0.42
READ	chr8	61665051	Intron	novel		0.44
READ	chr8	61665149	Intron	novel		0.16
READ	chr8	61668235	Intron	NA		0.41
READ	chr8	61578238	Intron	novel		0.31
READ	chr8	61664800	Intron	novel		0.29
SARC	chr8	61646807	Missense_Mutation	novel	M188L	0.57
SARC	chr8	61503377	Silent	novel	R753R	0.15
SARC	chr8	61526094	Missense_Mutation	novel	K595E	0.17
SARC	chr8	61517593	Silent	novel	L687L	0.25
SARC	chr8	61624915	Intron	novel		0.33
SARC	chr8	61626261	Intron	novel		0.17
SARC	chr8	61646810	Missense_Mutation	novel	L187F	0.29
SKCM	chr8	61503438	Missense_Mutation	NA	S733F	0.31
SKCM	chr8	61653625	Missense_Mutation	novel	P120S	0.51
SKCM	chr8	61578490	Intron	novel		0.46
SKCM	chr8	61665214	Intron	novel		0.31
SKCM	chr8	61553069	Missense_Mutation	novel	H530Y	0.25
SKCM	chr8	61579595	Intron	novel		0.15
SKCM	chr8	61642894	Missense_Mutation	NA	E262K	0.33
SKCM	chr8	61576834	Missense_Mutation	novel	A363P	0.08
SKCM	chr8	61578369	Intron	novel		0.22
SKCM	chr8	61681008	Silent	NA	G94G	0.36
SKCM	chr8	61578459	Intron	novel		0.42
SKCM	chr8	61638356	Nonsense_Mutation	NA	Y266*	0.34
SKCM	chr8	61653593	Silent	rs575705988	P130P	0.46
SKCM	chr8	61643392	Missense_Mutation	novel	D251N	0.17
SKCM	chr8	61567226	Silent	NA	V414V	0.28
SKCM	chr8	61579034	Intron	novel		0.35
SKCM	chr8	61579290	Intron	novel		0.25
SKCM	chr8	61517568	Missense_Mutation	NA	P696S	0.14
SKCM	chr8	61579137	Intron	novel		0.18
SKCM	chr8	61579008	Intron	novel		0.2
SKCM	chr8	61553107	Missense_Mutation	NA	S517F	0.18
SKCM	chr8	61676225	Intron	novel		0.15
SKCM	chr8	61579630	Intron	novel		0.25
SKCM	chr8	61579631	Intron	novel		0.24
SKCM	chr8	61665232	Intron	novel		0.15
SKCM	chr8	61578917	Intron	novel		0.37
SKCM	chr8	61578918	Intron	novel		0.36
SKCM	chr8	61503258	3'UTR	novel		0.26
SKCM	chr8	61578234	Intron	novel		0.77
SKCM	chr8	61562815	Silent	NA	L456L	0.36
SKCM	chr8	61576807	Missense_Mutation	rs760581343	P372S	0.43
SKCM	chr8	61576808	Silent	rs763769704	Y371Y	0.42
SKCM	chr8	61567229	Silent	novel	D413D	0.43
SKCM	chr8	61578460	Intron	novel		0.17
SKCM	chr8	61579336	Intron	novel		0.34
SKCM	chr8	61555936	Silent	rs575763342	I508I	0.41
STAD	chr8	61578612	Intron	novel		0.35
STAD	chr8	61503432	Missense_Mutation	rs371485848	R735Q	0.13
STAD	chr8	61665190	Intron	novel		0.08
STAD	chr8	61567257	Missense_Mutation	NA	T404I	0.09
STAD	chr8	61562777	Silent	NA	G468G	0.19
STAD	chr8	61553080	Missense_Mutation	novel	R526I	0.05
STAD	chr8	61651110	Missense_Mutation	rs758840739	E144K	0.35
STAD	chr8	61578840	Intron	novel		0.13
STAD	chr8	61503461	Silent	rs112982646	H725H	0.16
STAD	chr8	61579349	Intron	novel		0.21
STAD	chr8	61680996	Frame_Shift_Del	novel	*F98Lfs10**	0.17
STAD	chr8	61562797	Missense_Mutation	rs200072789	V462M	0.31
STAD	chr8	61517541	Missense_Mutation	rs749030670	A705T	0.1
STAD	chr8	61578267	Intron	novel		0.22
STAD	chr8	61579218	Intron	novel		0.2
STAD	chr8	61637979	Missense_Mutation	NA	N286S	0.15
STAD	chr8	61579531	Intron	NA		0.12
STAD	chr8	61579009	Intron	novel		0.15
STAD	chr8	61579293	Intron	NA		0.07
STAD	chr8	61567300	Missense_Mutation	novel	E390Q	0.09
STAD	chr8	61579043	Intron	novel		0.14
STAD	chr8	61517596	Silent	NA	R686R	0.31
STAD	chr8	61579020	Intron	novel		0.47
STAD	chr8	61553106	Silent	rs373467138	S517S	0.17
STAD	chr8	61578640	Intron	novel		0.2
STAD	chr8	61676229	Intron	novel		0.11
STAD	chr8	61676271	Intron	novel		0.1
STAD	chr8	61643426	Silent	NA	S239S	0.21
THCA	chr8	61665374	Intron	novel		0.11
THCA	chr8	61665375	Intron	novel		0.07
UCEC	chr8	61579458	Intron	novel		0.58
UCEC	chr8	61579590	Intron	novel		0.4
UCEC	chr8	61578394	Intron	novel		0.1
UCEC	chr8	61562757	Missense_Mutation	NA	K475R	0.27
UCEC	chr8	61664908	Intron	novel		0.13
UCEC	chr8	61664977	Intron	novel		0.35
UCEC	chr8	61676235	Intron	novel		0.09
UCEC	chr8	61684165	Missense_Mutation	novel	N43H	0.1
UCEC	chr8	61624788	Intron	novel		0.47
UCEC	chr8	61633706	Missense_Mutation	novel	E304G	0.41
UCEC	chr8	61651110	Missense_Mutation	rs758840739	E144K	0.44
UCEC	chr8	61689737	Intron	novel		0.44
UCEC	chr8	61681037	Splice_Site	novel	X85_splice	0.28
UCEC	chr8	61579291	Intron	novel		0.1
UCEC	chr8	61584025	Missense_Mutation	NA	K327N	0.41
UCEC	chr8	61651095	Nonsense_Mutation	novel	E149*	0.47
UCEC	chr8	61653648	Missense_Mutation	novel	R112I	0.36
UCEC	chr8	61576791	Missense_Mutation	novel	A377V	0.54
UCEC	chr8	61665406	Intron	rs758020573		0.15
UCEC	chr8	61503433	Missense_Mutation	rs374385878	R735W	0.5
UCEC	chr8	61567261	Missense_Mutation	rs368575612	E403K	0.11
UCEC	chr8	61676137	Intron	rs374033675		0.28
UCEC	chr8	61684097	Silent	rs202006022	G65G	0.1
UCEC	chr8	61579123	Intron	novel		0.24
UCEC	chr8	61548150	Missense_Mutation	rs771474720	R562H	0.17
UCEC	chr8	61579307	Intron	novel		0.39
UCEC	chr8	61665085	Intron	novel		0.19
UCEC	chr8	61665194	Intron	novel		0.12
UCEC	chr8	61689679	Intron	novel		0.26
UCEC	chr8	61548191	Missense_Mutation	NA	E548D	0.25
UCEC	chr8	61644627	Missense_Mutation	rs201124803	E209K	0.2
UCEC	chr8	61646814	Missense_Mutation	NA	E185D	0.44
UCEC	chr8	61665561	Intron	novel		0.06
UCEC	chr8	61579326	Intron	novel		0.48
UCEC	chr8	61576825	Nonsense_Mutation	novel	E366*	0.42
UCEC	chr8	61625015	Intron	novel		0.31
UCEC	chr8	61518112	Nonsense_Mutation	NA	E638*	0.49
UCEC	chr8	61578240	Intron	novel		0.09
UCEC	chr8	61578810	Intron	novel		0.12
UCEC	chr8	61624985	Intron	novel		0.54
UCEC	chr8	61626169	Intron	novel		0.37
UCEC	chr8	61646823	Silent	rs777861394	E182E	0.25
UCEC	chr8	61689679	Intron	novel		0.34
UCEC	chr8	61578361	Intron	novel		0.36
UCEC	chr8	61579233	Intron	NA		0.19
UCEC	chr8	61624760	Intron	novel		0.21
UCEC	chr8	61651058	Missense_Mutation	novel	A161V	0.33
UCEC	chr8	61676196	Intron	novel		0.19
UCEC	chr8	61526085	Nonsense_Mutation	novel	R598*	0.45
UCEC	chr8	61626256	Intron	novel		0.42
UCEC	chr8	61665521	Intron	novel		0.42
UCEC	chr8	61684174	Nonsense_Mutation	NA	G40*	0.5
UCEC	chr8	61579501	Intron	novel		0.26
UCEC	chr8	61665190	Intron	novel		0.47
UCEC	chr8	61578617	Intron	novel		0.59
UCEC	chr8	61624788	Intron	novel		0.4
UCEC	chr8	61625339	Intron	novel		0.48
UCEC	chr8	61638331	Nonsense_Mutation	NA	E275*	0.29
UCEC	chr8	61684140	Missense_Mutation	novel	G51E	0.63
UCEC	chr8	61503277	3'UTR	novel		0.27
UCEC	chr8	61665601	Intron	rs752602644		0.53
UCEC	chr8	61576802	Missense_Mutation	NA	Q373H	0.22
UCEC	chr8	61665049	Intron	novel		0.33
UCEC	chr8	61556014	Missense_Mutation	NA	S482R	0.1
UCEC	chr8	61579090	Intron	novel		0.18
UCEC	chr8	61503277	3'UTR	novel		0.23
UCEC	chr8	61526085	Nonsense_Mutation	novel	R598*	0.36
UCEC	chr8	61503277	3'UTR	novel		0.25
UCEC	chr8	61576809	Missense_Mutation	rs776684832	Y371S	0.43
UCEC	chr8	61665501	Intron	rs555432849		0.21
UCEC	chr8	61503458	Missense_Mutation	NA	E726D	0.25
UCEC	chr8	61578947	Intron	novel		0.34
UCEC	chr8	61665502	Intron	rs746060282		0.36
UCEC	chr8	61578639	Intron	novel		0.35
UCEC	chr8	61689697	Intron	novel		0.54
UCEC	chr8	61675831	Intron	novel		0.12
UCEC	chr8	61562786	Silent	novel	L465L	0.1
UCEC	chr8	61578830	Intron	novel		0.11
UCEC	chr8	61638004	Splice_Site	novel	X278_splice	0.17
UCEC	chr8	61651095	Nonsense_Mutation	novel	E149*	0.43
UCEC	chr8	61676033	Intron	novel		0.29
UCEC	chr8	61579618	Intron	novel		0.26
UCEC	chr8	61665483	Intron	novel		0.21
UCEC	chr8	61518077	Silent	novel	T649T	0.32
UCEC	chr8	61646823	Missense_Mutation	NA	E182D	0.29
UCEC	chr8	61555940	Missense_Mutation	novel	S507N	0.07
UCEC	chr8	61684075	Missense_Mutation	rs774320459	V73I	0.4
UCEC	chr8	61626152	Intron	novel		0.32
UCEC	chr8	61664906	Intron	novel		0.25
UCEC	chr8	61665560	Intron	novel		0.38
UCEC	chr8	61517547	Nonsense_Mutation	rs773987662	R703*	0.16
UCEC	chr8	61553060	Frame_Shift_Del	NA	*D533Mfs35**	0.26
UCEC	chr8	61651065	Missense_Mutation	rs767403241	V159I	0.18
UCEC	chr8	61576853	Silent	novel	K356K	0.07
UCEC	chr8	61665427	Intron	NA		0.12
UCEC	chr8	61643994	Missense_Mutation	NA	Q220H	0.42
UCEC	chr8	61676079	Intron	novel		0.33
UCEC	chr8	61548130	Missense_Mutation	novel	G569R	0.2
UCEC	chr8	61576776	Missense_Mutation	rs749737562	A382V	0.4
UCEC	chr8	61578904	Intron	novel		0.38
UCEC	chr8	61633690	Silent	novel	V309V	0.37
UCEC	chr8	61665377	Intron	novel		0.24
UCEC	chr8	61689767	Intron	novel		0.23
UCEC	chr8	61651107	Missense_Mutation	novel	D145Y	0.4
UCEC	chr8	61665527	Intron	novel		0.01
UCEC	chr8	61517600	Missense_Mutation	NA	C685Y	0.29
UCEC	chr8	61665085	Intron	novel		0.31
UCEC	chr8	61553102	Missense_Mutation	novel	D519N	0.33
UCEC	chr8	61567191	Missense_Mutation	rs772711048	R426H	0.46
UCEC	chr8	61567280	Silent	novel	E396E	0.45
UCEC	chr8	61626095	Intron	novel		0.62
UCEC	chr8	61579065	Intron	novel		0.32
UCEC	chr8	61625346	Intron	novel		0.56
UCEC	chr8	61638341	Silent	novel	N271N	0.14
UCEC	chr8	61643399	Silent	novel	L248L	0.25
UCEC	chr8	61689680	Intron	novel		0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.1458	0.021977
READ	DEL	0.0424	0.20625
SARC	AMP	0.2685	0.18425
THCA	DEL	0.008	0.038162

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0077	Kaplan-Meier Survival Analysis
MESO	0.013	Kaplan-Meier Survival Analysis
ACC	0.028	Kaplan-Meier Survival Analysis
HNSC	0.037	Kaplan-Meier Survival Analysis
KIRP	0.00017	Kaplan-Meier Survival Analysis
COAD	0.035	Kaplan-Meier Survival Analysis
PAAD	0.00041	Kaplan-Meier Survival Analysis
CESC	0.0001	Kaplan-Meier Survival Analysis
LAML	0.00027	Kaplan-Meier Survival Analysis
KICH	0.013	Kaplan-Meier Survival Analysis
LIHC	0.021	Kaplan-Meier Survival Analysis
THCA	0.0059	Kaplan-Meier Survival Analysis
LUAD	0.0028	Kaplan-Meier Survival Analysis
UVM	0.0051	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000198363 (Gene tree)
Gene ID: 444
Gene Symbol: ASPH
Alias: CASQ2BP1|BAH|JCTN|HAAH
Full Name: aspartate beta-hydroxylase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 214,085 bases
Position: chr8:61,500,556-61,714,640
Accession: 757
RBP type: non-canonical RBP
Summary: This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000519678	ASPH-216	536	-	ENSP00000483443	134 (aa)	-	A0A087X0J4
ENST00000522036	ASPH-220	663	-	-	- (aa)	-	-
ENST00000523897	ASPH-227	871	-	-	- (aa)	-	-
ENST00000356457	ASPH-201	3730	XM_024447157	ENSP00000348841	313 (aa)	XP_024302925	Q12797
ENST00000517661	ASPH-206	809	XM_024447159	ENSP00000428060	174 (aa)	XP_024302927	G3XAN5
ENST00000517928	ASPH-210	548	-	-	- (aa)	-	-
ENST00000445642	ASPH-205	3717	-	ENSP00000394013	294 (aa)	-	Q12797
ENST00000517903	ASPH-209	2658	-	ENSP00000430245	298 (aa)	-	Q12797
ENST00000522603	ASPH-224	842	-	ENSP00000436188	210 (aa)	-	Q12797
ENST00000522919	ASPH-226	1277	-	ENSP00000430516	163 (aa)	-	E5RJL3
ENST00000379454	ASPH-203	5268	XM_005251235	ENSP00000368767	758 (aa)	XP_005251292	Q12797
ENST00000523927	ASPH-228	556	-	ENSP00000478706	186 (aa)	-	A0A087WUJ2
ENST00000517856	ASPH-208	6337	-	ENSP00000429743	113 (aa)	-	E5RHJ2
ENST00000519264	ASPH-215	337	-	ENSP00000479830	44 (aa)	-	A0A087WW05
ENST00000521499	ASPH-218	484	-	-	- (aa)	-	-
ENST00000520198	ASPH-217	544	-	-	- (aa)	-	-
ENST00000518306	ASPH-212	755	-	ENSP00000427877	198 (aa)	-	E5RG29
ENST00000522343	ASPH-222	329	-	-	- (aa)	-	-
ENST00000521909	ASPH-219	851	-	-	- (aa)	-	-
ENST00000522349	ASPH-223	531	-	ENSP00000429718	136 (aa)	-	E5RHK2
ENST00000522325	ASPH-221	665	-	-	- (aa)	-	-
ENST00000518068	ASPH-211	2744	-	ENSP00000429286	270 (aa)	-	Q12797
ENST00000389204	ASPH-204	1290	-	ENSP00000373856	225 (aa)	-	Q12797
ENST00000541428	ASPH-230	2550	XM_005251240	ENSP00000437864	729 (aa)	XP_005251297	Q12797
ENST00000524173	ASPH-229	587	-	ENSP00000479945	195 (aa)	-	A0A087WW51
ENST00000519234	ASPH-214	2874	-	ENSP00000427823	327 (aa)	-	E5RG56
ENST00000518441	ASPH-213	781	-	-	- (aa)	-	-
ENST00000517847	ASPH-207	1947	XM_017013445	ENSP00000429954	299 (aa)	XP_016868934	Q12797
ENST00000379449	ASPH-202	1603	-	ENSP00000368762	203 (aa)	-	Q12797
ENST00000522835	ASPH-225	1258	XM_017013447	ENSP00000429160	256 (aa)	XP_016868936	Q12797

Gene Model

Click here to download ENSG00000198363's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198363	rs112760834	8	61627575	T	Blood protein levels	29875488	[0.44-0.72] unit decrease	0.58	EFO_0007937
ENSG00000198363	rs142916219	8	61568961	G	Resting heart rate	28270201	[3.88-8.06] beats per minute increase	5.9711304	EFO_0004351
ENSG00000198363	rs2350923	8	61692700	T	BRCA1/2-negative high-risk breast cancer	30323354	[1.16-1.42]	1.28	EFO_0009443

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198363's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004597	peptide-aspartate beta-dioxygenase activity	-	IEA	Function
GO:0005198	structural molecule activity	11007777.	TAS	Function
GO:0005509	calcium ion binding	11007777.	NAS	Function
GO:0005515	protein binding	22586105.25416956.	IPI	Function
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005789	endoplasmic reticulum membrane	11007777.	NAS	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005886	plasma membrane	21062895.	IDA	Component
GO:0006936	muscle contraction	10974562.	TAS	Process
GO:0007389	pattern specification process	-	IEA	Process
GO:0008285	negative regulation of cell proliferation	-	IEA	Process
GO:0008307	structural constituent of muscle	11007777.	TAS	Function
GO:0009055	electron transfer activity	7821814.	TAS	Function
GO:0016021	integral component of membrane	-	IEA	Component
GO:0022900	electron transport chain	-	IEA	Process
GO:0031647	regulation of protein stability	-	IEA	Process
GO:0032541	cortical endoplasmic reticulum	21062895.	IDA	Component
GO:0033017	sarcoplasmic reticulum membrane	-	IEA	Component
GO:0034220	ion transmembrane transport	-	TAS	Process
GO:0035108	limb morphogenesis	-	IEA	Process
GO:0042264	peptidyl-aspartic acid hydroxylation	-	IEA	Process
GO:0045862	positive regulation of proteolysis	18387192.	IDA	Process
GO:0060021	roof of mouth development	-	IEA	Process
GO:0060325	face morphogenesis	-	IEA	Process
GO:0097202	activation of cysteine-type endopeptidase activity	18387192.	IDA	Process
GO:1901879	regulation of protein depolymerization	-	IEA	Process
GO:1903779	regulation of cardiac conduction	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.