EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27509259	Loss of GFAT1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.	Oncotarget	2016 Jun 21	Duan F	doi: 10.18632/oncotarget.9538.
26715276	Altered glycometabolism affects both clinical features and prognosis of triple-negative and neoadjuvant chemotherapy-treated breast cancer.	Tumour Biol	2016 Jun	Dong T	doi: 10.1007/s13277-015-4729-8
27996048	High expression of GFAT1 predicts poor prognosis in patients with pancreatic cancer.	Sci Rep	2016 Dec 20	Yang C	doi: 10.1038/srep39044.
30305725	IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells.	Oncogene	2019 Feb	Shimizu M	doi: 10.1038/s41388-018-0533-4

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	69363662	Missense_Mutation	NA	D78N	0.36
BLCA	chr2	69345923	Silent	novel	V362V	0.17
BLCA	chr2	69354507	Missense_Mutation	novel	P223A	0.06
BLCA	chr2	69348196	Silent	NA	Q328Q	0.54
BLCA	chr2	69328291	Missense_Mutation	novel	Q625K	0.13
BLCA	chr2	69354521	Missense_Mutation	novel	S218Y	0.21
BLCA	chr2	69342226	Missense_Mutation	NA	H377D	0.17
BRCA	chr2	69342194	Missense_Mutation	NA	L387F	0.27
BRCA	chr2	69350166	Missense_Mutation	novel	S253R	0.07
BRCA	chr2	69327066	Missense_Mutation	NA	V635L	0.23
BRCA	chr2	69358385	Missense_Mutation	rs770856462	R163W	0.06
BRCA	chr2	69374015	Missense_Mutation	NA	D36Y	0.19
CESC	chr2	69327039	Missense_Mutation	novel	E644K	0.42
CESC	chr2	69345909	Missense_Mutation	NA	Y367S	0.38
CESC	chr2	69338559	Missense_Mutation	NA	Q404E	0.37
CESC	chr2	69342202	Missense_Mutation	novel	R385W	0.25
CESC	chr2	69326965	Silent	NA	V668V	0.25
CESC	chr2	69354513	Missense_Mutation	novel	H221D	0.39
CESC	chr2	69348178	Silent	NA	I334I	0.26
COAD	chr2	69328345	Missense_Mutation	NA	V607M	0.26
COAD	chr2	69329321	In_Frame_Del	NA	Y567del	0.31
COAD	chr2	69338031	Missense_Mutation	novel	G450D	0.31
COAD	chr2	69374093	Missense_Mutation	NA	Y10H	0.26
COAD	chr2	69326085	3'UTR	novel		0.42
COAD	chr2	69358463	Missense_Mutation	NA	E137K	0.18
COAD	chr2	69345955	Missense_Mutation	novel	E352K	0.34
COAD	chr2	69326991	Missense_Mutation	NA	D660N	0.17
DLBC	chr2	69337960	Missense_Mutation	novel	R474W	0.32
ESCA	chr2	69338497	Missense_Mutation	novel	D424E	0.08
GBM	chr2	69328324	Missense_Mutation	novel	D614Y	0.29
GBM	chr2	69338528	Missense_Mutation	novel	V414A	0.28
GBM	chr2	69350125	Silent	novel	F266F	0.49
GBM	chr2	69363562	Missense_Mutation	rs189717232	R111H	0.21
GBM	chr2	69363662	Missense_Mutation	novel	D78Y	0.23
GBM	chr2	69348297	Missense_Mutation	rs764200601	E295K	0.37
GBM	chr2	69356532	Missense_Mutation	NA	K190R	0.08
HNSC	chr2	69337994	Silent	novel	V462V	0.38
HNSC	chr2	69329719	Missense_Mutation	NA	R521H	0.2
HNSC	chr2	69374051	Missense_Mutation	novel	I24L	0.25
LAML	chr2	69338530	Silent	NA	P413P	0.08
LGG	chr2	69327008	Missense_Mutation	rs751623973	K654R	0.28
LGG	chr2	69370029	Missense_Mutation	novel	K65N	0.09
LGG	chr2	69374069	Missense_Mutation	novel	E18K	0.22
LIHC	chr2	69358464	Splice_Site	novel	X137_splice	0.31
LUAD	chr2	69338496	Nonsense_Mutation	NA	R425*	0.18
LUAD	chr2	69370097	Missense_Mutation	novel	D43N	0.47
LUAD	chr2	69350079	Frame_Shift_Del	novel	*S282Vfs4**	0.64
LUAD	chr2	69337957	Missense_Mutation	NA	E475K	0.25
LUAD	chr2	69348264	Missense_Mutation	NA	R306C	0.24
LUAD	chr2	69374113	Missense_Mutation	NA	G3V	0.3
LUAD	chr2	69374011	Missense_Mutation	novel	S37F	0.25
LUAD	chr2	69342170	Missense_Mutation	NA	S395R	0.04
LUAD	chr2	69329771	Missense_Mutation	NA	V504L	0.07
LUSC	chr2	69329757	Silent	novel	L508L	0.37
LUSC	chr2	69358455	Missense_Mutation	novel	K139N	0.4
LUSC	chr2	69370093	Missense_Mutation	NA	G44E	0.06
LUSC	chr2	69354536	Missense_Mutation	novel	S213I	0.18
LUSC	chr2	69328374	Missense_Mutation	novel	P597L	0.37
LUSC	chr2	69342251	Splice_Site	NA	X369_splice	0.12
PAAD	chr2	69326205	Missense_Mutation	novel	S695Y	0.25
READ	chr2	69370080	Missense_Mutation	novel	K48N	0.06
READ	chr2	69370081	Missense_Mutation	novel	K48R	0.06
READ	chr2	69359305	Missense_Mutation	novel	G124E	0.37
READ	chr2	69348248	Missense_Mutation	rs536982477	R311Q	0.15
SKCM	chr2	69348220	Silent	novel	P320P	0.26
SKCM	chr2	69348221	Missense_Mutation	novel	P320L	0.25
SKCM	chr2	69342243	Nonsense_Mutation	novel	L371*	0.57
SKCM	chr2	69350150	Missense_Mutation	novel	R258H	0.12
SKCM	chr2	69387116	5'UTR	novel		0.38
SKCM	chr2	69387117	5'UTR	novel		0.38
SKCM	chr2	69359306	Missense_Mutation	novel	G124R	0.3
SKCM	chr2	69374049	Silent	rs773258998	I24I	0.06
SKCM	chr2	69338458	Silent	NA	F437F	0.52
SKCM	chr2	69328433	Silent	NA	I577I	0.41
SKCM	chr2	69337995	Missense_Mutation	NA	V462A	0.11
STAD	chr2	69326169	3'UTR	novel		0.31
STAD	chr2	69326171	3'UTR	novel		0.26
STAD	chr2	69363563	Missense_Mutation	rs201322234	R111C	0.12
STAD	chr2	69338538	Missense_Mutation	novel	E411Q	0.1
STAD	chr2	69359275	Missense_Mutation	NA	K134T	0.47
STAD	chr2	69350169	Missense_Mutation	NA	G252R	0.38
STAD	chr2	69363562	Missense_Mutation	rs189717232	R111H	0.22
STAD	chr2	69342201	Missense_Mutation	NA	R385Q	0.09
STAD	chr2	69328343	Silent	NA	V607V	0.31
STAD	chr2	69354498	Missense_Mutation	NA	Y226H	0.13
STAD	chr2	69342215	Silent	rs781010273	E380E	0.08
THCA	chr2	69370093	Missense_Mutation	NA	G44E	0.39
UCEC	chr2	69326191	Nonstop_Mutation	novel	700Rext26	0.36
UCEC	chr2	69348248	Missense_Mutation	rs536982477	R311Q	0.33
UCEC	chr2	69342199	Missense_Mutation	novel	R386C	0.13
UCEC	chr2	69374080	Missense_Mutation	NA	R14Q	0.43
UCEC	chr2	69354313	Splice_Site	novel	X229_splice	0.2
UCEC	chr2	69329724	Silent	NA	E519E	0.26
UCEC	chr2	69329688	Silent	novel	L531L	0.11
UCEC	chr2	69329392	Missense_Mutation	rs755583835	E544K	0.21
UCEC	chr2	69358416	Silent	novel	I152I	0.35
UCEC	chr2	69348215	Missense_Mutation	NA	R322Q	0.22
UCEC	chr2	69326208	Missense_Mutation	NA	K694T	0.15
UCEC	chr2	69359318	Missense_Mutation	rs776244383	V120I	0.2
UCEC	chr2	69328347	Missense_Mutation	novel	P606H	0.16
UCEC	chr2	69356506	Missense_Mutation	novel	V199I	0.47
UCEC	chr2	69348234	Missense_Mutation	NA	A316T	0.24
UCEC	chr2	69342194	Silent	novel	L387L	0.25
UCEC	chr2	69374071	Missense_Mutation	rs775399768	R17Q	0.29
UCEC	chr2	69342250	Splice_Site	NA	X369_splice	0.32
UCEC	chr2	69328429	Nonsense_Mutation	novel	E579*	0.6
UCEC	chr2	69326018	3'UTR	novel		0.31
UCEC	chr2	69370028	Missense_Mutation	novel	V66I	0.43
UCEC	chr2	69338464	Nonsense_Mutation	novel	C435*	0.58
UCEC	chr2	69374086	Missense_Mutation	novel	V12A	0.51
UCEC	chr2	69325923	3'UTR	novel		0.43
UCEC	chr2	69363644	Nonsense_Mutation	NA	E84*	0.42
UCEC	chr2	69359267	Splice_Site	novel	X136_splice	0.23
UCEC	chr2	69342177	Missense_Mutation	novel	G393E	0.25
UCEC	chr2	69326967	Missense_Mutation	novel	V668M	0.33
UCEC	chr2	69326220	Missense_Mutation	novel	R690Q	0.18
UCEC	chr2	69338541	Missense_Mutation	novel	T410S	0.26
UCEC	chr2	69363628	Missense_Mutation	novel	L89P	0.32
UCEC	chr2	69348248	Missense_Mutation	rs536982477	R311Q	0.46
UCEC	chr2	69363569	Missense_Mutation	NA	P109T	0.52
UCEC	chr2	69327072	Missense_Mutation	novel	R633W	0.38
UCEC	chr2	69328429	Missense_Mutation	NA	E579K	0.48
UCEC	chr2	69337919	Silent	novel	E487E	0.11
UCEC	chr2	69338027	Silent	novel	L451L	0.04
UCEC	chr2	69363562	Missense_Mutation	rs189717232	R111H	0.51
UCEC	chr2	69348239	Missense_Mutation	novel	R314Q	0.35
UCS	chr2	69326919	Missense_Mutation	novel	Y684H	0.53

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0489	0.2014
READ	DEL	0.0667	0.19022

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.011	Kaplan-Meier Survival Analysis
SARC	0.0012	Kaplan-Meier Survival Analysis
SKCM	0.032	Kaplan-Meier Survival Analysis
PRAD	0.023	Kaplan-Meier Survival Analysis
BRCA	0.023	Kaplan-Meier Survival Analysis
ESCA	0.048	Kaplan-Meier Survival Analysis
KIRP	0.0064	Kaplan-Meier Survival Analysis
COAD	0.0014	Kaplan-Meier Survival Analysis
READ	0.015	Kaplan-Meier Survival Analysis
LAML	0.00032	Kaplan-Meier Survival Analysis
KICH	0.022	Kaplan-Meier Survival Analysis
LIHC	0.0071	Kaplan-Meier Survival Analysis
UVM	0.00096	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000198380 (Gene tree)
Gene ID: 2673
Gene Symbol: GFPT1
Alias: GFAT|GFA|GFAT1|GFPT
Full Name: glutamine--fructose-6-phosphate transaminase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 67,486 bases
Position: chr2:69,319,769-69,387,254
Accession: 4241
RBP type: non-canonical RBP
Summary: This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000357308	GFPT1-201	8703	XM_017003801	ENSP00000349860	699 (aa)	XP_016859290	Q06210
ENST00000361060	GFPT1-202	8632	XM_017003802	ENSP00000354347	681 (aa)	XP_016859291	Q06210
ENST00000493759	GFPT1-203	524	-	-	- (aa)	-	-
ENST00000494201	GFPT1-204	625	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000198380's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00250	Alanine, aspartate and glutamate metabolism	KEGG
hsa00520	Amino sugar and nucleotide sugar metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04931	Insulin resistance	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198380	rs4410328	2	69373551	?	Body fat percentage	30593698	[0.071-0.155] unit decrease	0.11318	EFO_0007800
ENSG00000198380	rs4410328	2	69373551	?	Body fat percentage	30593698	[0.078-0.182] unit decrease	0.12996	EFO_0007800

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198380's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004360	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	21873635.	IBA	Function
GO:0005829	cytosol	-	TAS	Component
GO:0006002	fructose 6-phosphate metabolic process	21873635.	IBA	Process
GO:0006047	UDP-N-acetylglucosamine metabolic process	21873635.	IBA	Process
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	-	IEA	Process
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	-	TAS	Process
GO:0006112	energy reserve metabolic process	1460020.	TAS	Process
GO:0006487	protein N-linked glycosylation	21873635.	IBA	Process
GO:0006541	glutamine metabolic process	-	IEA	Process
GO:0032922	circadian regulation of gene expression	-	ISS	Process
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0097367	carbohydrate derivative binding	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.