EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23220088??-Catenin overexpression promotes angiogenic potential of CWR22Rv-1 prostate cancer cells via HIF-1α and VEGF.FEBS Lett2013 Jan 16He Ydoi: 10.1016/j.febslet.2012.11.024
19284555delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles.Mol Cancer2009 Mar 10Zeng Ydoi: 10.1186/1476-4598-8-19.
20118984Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer.Oncogene2010 Apr 22Cheung LWdoi: 10.1038/onc.2009.523
19763914p120ctn isoform 1 expression significantly correlates with abnormal expression of E-cadherin and poor survival of lung cancer patients.Med Oncol2010 SepMiao Ydoi: 10.1007/s12032-009-9300-2
12671892Up-regulation, nuclear import, and tumor growth stimulation of the adhesion protein p120 in pancreatic cancer.Gastroenterology2003 AprMayerle J-
27193094Overexpression of CTNND1 in hepatocellular carcinoma promotes carcinous characters through activation of Wnt/β-catenin signaling.J Exp Clin Cancer Res2016 May 18Tang Bdoi: 10.1186/s13046-016-0344-9.
12492499Altered expression of the catenin p120 in human cancer: implications for tumor progression.Differentiation2002 DecThoreson MA-
18595142Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters.World J Gastroenterol2008 Jun 21Zhai B-
17383052Expression of E-cadherin, beta-catenin and p120ctn in the pulmonary sclerosing hemangioma.Lung Cancer2007 JulDai SD-
22846708FERM-containing protein FRMD5 is a p120-catenin interacting protein that regulates tumor progression.FEBS Lett2012 Sep 21Wang Tdoi: 10.1016/j.febslet.2012.07.019
26464646Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-γ1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma.Int J Clin Exp Pathol2015 Aug 1Jiang Y-
18407999A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease.J Biol Chem2008 Jun 27Yanagisawa Mdoi: 10.1074/jbc.M801192200
22583808Regulation of adherens junctions by Rho GTPases and p120-catenin.Arch Biochem Biophys2012 Aug 1Menke Adoi: 10.1016/j.abb.2012.04.019
28295003[Epithelial cadherins and associated molecules in invasive lobular breast cancer].Arkh Patol2017Brilliant YMdoi: 10.17116/patol201779112-18.
29216867Protein kinase C α enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin.BMC Cancer2017 Dec 7Pham TNDdoi: 10.1186/s12885-017-3827-y.
21070476Upregulation of ??-catenin is associated with poor prognosis and enhances transcriptional activity through Kaiso in non-small-cell lung cancer.Cancer Sci2011 JanDai SDdoi: 10.1111/j.1349-7006.2010.01766.x
15161659Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer.Am J Pathol2004 JunShibata T-
20460685p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells.Mol Cancer Res2010 MayMortazavi Fdoi: 10.1158/1541-7786.MCR-10-0004
24412473C-Src-mediated phosphorylation of ??-catenin increases its protein stability and the ability of inducing nuclear distribution of β-catenin.Biochim Biophys Acta2014 AprHe Ydoi: 10.1016/j.bbamcr.2013.12.021
25634213Chemotherapy-Induced miRNA-29c/Catenin-?? Signaling Suppresses Metastasis in Gastric Cancer.Cancer Res2015 Apr 1Wang Ydoi: 10.1158/0008-5472.CAN-14-0787
26067913Pro-Tumorigenic Phosphorylation of p120 Catenin in Renal and Breast Cancer.PLoS One2015 Jun 11Kourtidis Adoi: 10.1371/journal.pone.0129964
19116988Identification of extracellular delta-catenin accumulation for prostate cancer detection.Prostate2009 Mar 1Lu Qdoi: 10.1002/pros.20902.
20232357Downregulation of HDPR1 is associated with poor prognosis and affects expression levels of p120-catenin and beta-catenin in nonsmall cell lung cancer.Mol Carcinog2010 MayYang ZQdoi: 10.1002/mc.20622.
19154401Ablation of p120-catenin enhances invasion and metastasis of human lung cancer cells.Cancer Sci2009 MarLiu Ydoi: 10.1111/j.1349-7006.2008.01067.x
21481789Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.Cancer Cell2011 Apr 12Stairs DBdoi: 10.1016/j.ccr.2011.02.007.
21317933P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin.Oncogene2011 Jun 30Cheung LWdoi: 10.1038/onc.2011.7
19150613P120-catenin isoforms 1A and 3A differently affect invasion and proliferation of lung cancer cells.Exp Cell Res2009 Mar 10Liu Ydoi: 10.1016/j.yexcr.2008.12.016
23614500The clinical significance of mesenchyme forkhead 1 (FoxC2) in gastric carcinoma.Histopathology2013 JunZhu JLdoi: 10.1111/his.12132
19615783Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn.Lung Cancer2010 FebDai SDdoi: 10.1016/j.lungcan.2009.06.013
15561585Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer.Semin Cell Dev Biol2004 DecReynolds AB-
24498333Kaiso interacts with p120-catenin to regulate β-catenin expression at the transcriptional level.PLoS One2014 Feb 3Liu Ydoi: 10.1371/journal.pone.0087537
25470111Catenin-??1, negatively regulated by miR-145, promotes tumour aggressiveness in gastric cancer.J Pathol2015 MayXing AYdoi: 10.1002/path.4495
21336985c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells.Clin Exp Metastasis2011 AprMortazavi Fdoi: 10.1007/s10585-011-9378-8
16226102Increased expression of delta-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer.Hum Pathol2005 OctLu Q-
26062780Overexpression of ??-catenin is associated with a malignant phenotype and poor prognosis in colorectal cancer.Mol Med Rep2015 SepZhang Hdoi: 10.3892/mmr.2015.3918
18032823Expression of p120-catenin isoforms correlates with genomic and transcriptional phenotype of breast cancer cell lines.Cell Oncol2007Paredes J-
23423910Delta-catenin promotes the proliferation and invasion of colorectal cancer cells by binding to E-cadherin in a competitive manner with p120 catenin.Target Oncol2014 MarZhang Hdoi: 10.1007/s11523-013-0269-6
20151151Altered expression of p120catenin predicts poor outcome in invasive breast cancer.J Cancer Res Clin Oncol2010 SepTalvinen Kdoi: 10.1007/s00432-010-0789-8
22276175P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively.PLoS One2012Jiang Gdoi: 10.1371/journal.pone.0030303
21468542p120-catenin isoform 3 regulates subcellular localization of Kaiso and promotes invasion in lung cancer cells via a phosphorylation-dependent mechanism.Int J Oncol2011 JunZhang PXdoi: 10.3892/ijo.2011.995
20668551p120ctn and P-cadherin but not E-cadherin regulate cell motility and invasion of DU145 prostate cancer cells.PLoS One2010 Jul 27K??mper Sdoi: 10.1371/journal.pone.0011801.
21385933Involvement of the TGF-beta and beta-catenin pathways in pelvic lymph node metastasis in early-stage cervical cancer.Clin Cancer Res2011 Mar 15Noordhuis MGdoi: 10.1158/1078-0432.CCR-10-2320
26324182p120-catenin participates in the progress of gastric cancer through regulating the Rac1 and Pak1 signaling pathway.Oncol Rep2015 NovLi TFdoi: 10.3892/or.2015.4226

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1157801922SilentNAV382V0.14
BLCAchr1157803619Splice_SitenovelX474_splice0.6
BLCAchr1157809305Frame_Shift_DelnovelL759Rfs*120.27
BLCAchr1157803681Frame_Shift_DelnovelH495Pfs*20.21
BLCAchr1157809331Missense_MutationnovelS767F0.38
BLCAchr1157801867Missense_MutationnovelR364T0.09
BLCAchr1157815624Intronnovel0.24
BLCAchr1157803690Frame_Shift_DelnovelL497Cfs*130.49
BLCAchr1157815936Missense_MutationnovelL944V0.48
BLCAchr1157808420Nonsense_MutationnovelQ708*0.21
BLCAchr1157796913Missense_MutationnovelD293N0.19
BLCAchr1157804770Missense_MutationnovelS571L0.67
BLCAchr1157808210Missense_MutationnovelS670L0.13
BLCAchr1157808182Nonsense_MutationNAQ661*0.23
BRCAchr11578168903'UTRnovel0.22
BRCAchr1157801997SilentNAL407L0.12
BRCAchr1157809438Missense_MutationnovelE803K0.34
BRCAchr11578174803'UTRnovel0.38
BRCAchr11578180993'UTRnovel0.19
BRCAchr1157796826Missense_Mutationrs770665127R264W0.41
BRCAchr11578181893'UTRnovel0.16
BRCAchr11578165243'UTRnovel0.18
BRCAchr1157802158Missense_MutationNAR461Q0.09
BRCAchr11578164543'UTRnovel0.28
BRCAchr1157811480Frame_Shift_InsnovelK878Ifs*40.09
BRCAchr1157811481Nonsense_MutationnovelK878Nfs*20.09
BRCAchr1157796476Missense_Mutationrs760465020T147S0.2
BRCAchr1157796701Missense_MutationnovelP222R0.11
BRCAchr11578165123'UTRnovel0.4
CESCchr1157808468Missense_MutationNAE724K0.26
CESCchr1157809386SilentNAV785V0.1
CESCchr11578167443'UTRnovel0.45
CESCchr11578181043'UTRnovel0.2
CESCchr1157809390Missense_Mutationrs771218774A787T0.52
CESCchr11578180743'UTRnovel0.43
CESCchr1157796810SilentnovelG258G0.51
CESCchr1157804692Missense_MutationNAR545H0.26
CESCchr1157808292Splice_RegionNAT697T0.4
CESCchr11578173583'UTRnovel0.48
CESCchr1157802006SilentNAI410I0.25
CESCchr1157801884Missense_MutationNAE370Q0.23
CESCchr1157796862Missense_MutationnovelH276Y0.36
CHOLchr1157801788Missense_MutationnovelP338S0.45
COADchr1157809370Missense_MutationNAN780I0.29
COADchr1157808531Nonsense_MutationNAE745*0.43
COADchr1157809302Missense_MutationNAK757N0.3
COADchr1157815465Missense_MutationNAD925N0.35
COADchr11578164883'UTRnovel0.5
COADchr1157796594SilentNAG186G0.33
COADchr1157809427Frame_Shift_InsNAQ800Tfs*40.46
COADchr1157811420Nonsense_MutationNAR858*0.44
COADchr1157796827Missense_MutationNAR264Q0.09
COADchr1157803698Nonsense_MutationnovelE500*0.34
COADchr1157803623Missense_MutationNAT475P0.39
COADchr1157814353Frame_Shift_InsNAS895Ifs*80.33
COADchr1157803756Missense_Mutationrs758420026R519H0.33
COADchr1157796688Missense_MutationnovelE218K0.06
COADchr1157795729Splice_RegionNAT140T0.7
COADchr1157796471Silentrs372514468V145V0.31
COADchr1157810192Frame_Shift_DelNAE842Kfs*100.19
COADchr11577914665'UTRnovel0.25
COADchr1157794072SilentnovelN86N0.36
COADchr1157801837Missense_Mutationrs754613241R354H0.08
COADchr1157791582Missense_MutationNAR35H0.35
COADchr1157796814Nonsense_MutationNAQ260*0.27
COADchr1157808523Missense_Mutationrs201606412R742H0.08
COADchr1157796612SilentnovelP192P0.33
COADchr1157796890Missense_MutationnovelD285G0.1
COADchr1157808213Missense_MutationnovelL671R0.12
COADchr1157796781Missense_MutationNAR249W0.33
COADchr1157803666Missense_MutationNAI489S0.34
COADchr1157796989Missense_MutationnovelL318R0.07
COADchr1157801731Splice_SitenovelX319_splice0.15
COADchr1157802057SilentnovelG427G0.47
COADchr1157805934Missense_MutationNAR592Q0.08
ESCAchr11578167103'UTRnovel0.09
ESCAchr1157808406Missense_MutationnovelR703L0.14
ESCAchr11578182083'UTRnovel0.15
ESCAchr1157808536SilentnovelL746L0.48
ESCAchr1157808538Frame_Shift_DelnovelI747Mfs*100.48
ESCAchr1157796958Frame_Shift_DelnovelT308Lfs*170.2
ESCAchr1157809420Nonsense_MutationnovelR797*0.41
ESCAchr11578175183'UTRnovel0.34
ESCAchr1157815936Missense_MutationnovelL944V0.08
ESCAchr1157796842Missense_MutationnovelS269T0.47
ESCAchr1157808266Nonsense_MutationnovelQ689*0.28
GBMchr11578163333'UTRnovel0.29
HNSCchr1157796827Missense_MutationNAR264Q0.25
HNSCchr1157810214Frame_Shift_InsnovelD848Gfs*190.1
HNSCchr1157810216Frame_Shift_InsnovelD848Efs*90.1
HNSCchr1157795730Splice_SitenovelX140_splice0.19
HNSCchr1157791583SilentnovelR35R0.21
HNSCchr1157805918Missense_MutationnovelS587P0.22
HNSCchr1157811462Missense_MutationNAL872F0.05
HNSCchr11578163213'UTRrs7578672020.07
HNSCchr11578164623'UTRnovel0.19
HNSCchr1157802164Missense_Mutationrs755094282A463D0.34
HNSCchr1157801887Missense_MutationnovelV371L0.06
KIRCchr1157806472Missense_MutationNAS630P0.23
KIRCchr1157795595Missense_MutationNAY96D0.38
KIRCchr1157803677Missense_MutationNAA493T0.47
KIRPchr11578163513'UTRnovel0.36
LGGchr1157796696SilentnovelG220G0.23
LGGchr1157802096SilentnovelD440D0.3
LGGchr1157803673SilentnovelD491D0.32
LGGchr1157795713Missense_Mutationrs767448387R135Q0.22
LIHCchr1157810164Nonsense_MutationNAG831*0.26
LIHCchr1157810165Missense_MutationNAG831V0.26
LIHCchr1157795574Splice_Regionnovel0.08
LIHCchr1157802051Silentrs759069892H425H0.5
LIHCchr1157808225Missense_MutationNAS675N0.43
LIHCchr1157791558Missense_MutationnovelT27I0.12
LIHCchr1157815920Silentrs773613029D938D0.2
LUADchr1157801950Missense_MutationNAH392Y0.41
LUADchr1157802133Missense_MutationnovelV453L0.27
LUADchr1157796957SilentNAR307R0.26
LUADchr1157808523Missense_Mutationrs201606412R742L0.59
LUADchr1157796904Missense_MutationNAG290C0.39
LUADchr1157801914Missense_MutationnovelD380Y0.3
LUADchr1157801909Missense_MutationNAR378L0.23
LUADchr1157808225Missense_MutationnovelS675T0.34
LUSCchr1157816001Missense_MutationnovelM965I0.33
LUSCchr1157816002Splice_SitenovelX965_splice0.33
LUSCchr1157808401Silentrs762262057Y701Y0.28
LUSCchr1157803714Frame_Shift_DelnovelH505Lfs*80.37
LUSCchr1157796848Frame_Shift_InsnovelL272Sfs*140.22
LUSCchr1157809384Missense_MutationNAV785L0.32
LUSCchr1157815982Missense_MutationNAQ959L0.21
LUSCchr1157803766Missense_MutationnovelE522D0.36
LUSCchr1157810187SilentnovelP838P0.16
LUSCchr1157803721SilentNAG507G0.23
LUSCchr1157802051Missense_MutationnovelH425Q0.51
LUSCchr1157814366SilentnovelK898K0.16
LUSCchr1157796875Missense_MutationnovelY280C0.41
LUSCchr1157791592SilentnovelS38S0.19
LUSCchr1157796829Missense_MutationnovelV265I0.89
OVchr1157801999Frame_Shift_InsnovelK408Nfs*210.04
OVchr1157802059Missense_MutationnovelA428V0.21
OVchr1157805932SilentNAH591H0.31
OVchr1157802025Frame_Shift_InsnovelL417Sfs*110.14
PAADchr1157791602Missense_MutationnovelE42K0.16
PAADchr1157796699Frame_Shift_InsnovelG223Rfs*40.19
PAADchr1157796870SilentnovelE278E0.18
PAADchr1157815448Frame_Shift_DelnovelR919Hfs*50.11
PRADchr1157801782Missense_MutationnovelW336R0.2
READchr1157796488Missense_Mutationrs776232220R151Q0.51
READchr1157810131Nonsense_MutationNAR820*0.21
READchr1157801742SilentnovelE322E0.3
READchr1157795729Splice_RegionNAT140T0.28
READchr1157801911Missense_MutationNAL379V0.42
READchr11578165263'UTRnovel0.18
READchr1157815447Nonsense_MutationnovelR919*0.16
SARCchr1157808450Missense_MutationnovelL718F0.19
SARCchr1157809361Missense_MutationnovelS777C0.37
SARCchr1157808432Missense_MutationnovelL712V0.26
SARCchr11578177783'UTRnovel0.58
SARCchr1157814354SilentnovelG894G0.14
SARCchr11578180773'UTRnovel0.07
SKCMchr1157806959Missense_MutationNAP647S0.36
SKCMchr1157814325Missense_Mutationrs369783710R885W0.19
SKCMchr1157802052Missense_MutationnovelL426F0.36
SKCMchr1157796846SilentnovelV270V0.2
SKCMchr1157796847Missense_MutationnovelD271N0.2
SKCMchr1157810131Nonsense_MutationNAR820*0.25
SKCMchr1157808458SilentNAT720T0.13
SKCMchr1157806948Missense_MutationnovelT643I0.5
SKCMchr1157815475Missense_MutationnovelP928L0.33
SKCMchr1157796648SilentNAR204R0.31
SKCMchr1157815936SilentNAL944L0.67
SKCMchr1157809373Missense_MutationnovelT781I0.09
SKCMchr1157810197Missense_MutationNAE842K0.12
SKCMchr1157796582SilentnovelF182F0.25
STADchr1157796598Frame_Shift_DelnovelG189Dfs*460.28
STADchr1157808210Nonsense_MutationNAS670*0.15
STADchr1157810131Nonsense_MutationNAR820*0.12
STADchr1157815464Silentrs372445902G924G0.36
STADchr1157802117Frame_Shift_DelNAN449Tfs*490.16
STADchr1157803763Missense_MutationnovelI521M0.34
STADchr1157808245Missense_MutationNAE682K0.26
STADchr1157802117Frame_Shift_DelNAN449Tfs*490.32
STADchr1157808531Nonsense_MutationNAE745*0.33
STADchr1157802179In_Frame_DelnovelE470_T473del0.24
STADchr1157802116Frame_Shift_InsnovelN449Kfs*30.24
STADchr1157802148Nonsense_MutationNAR458*0.09
STADchr1157805910Missense_MutationnovelR584Q0.5
STADchr1157808471Missense_Mutationrs199570555R725W0.4
STADchr1157791579Missense_MutationnovelR34Q0.33
STADchr1157791579Missense_MutationnovelR34Q0.25
STADchr1157802106Nonsense_MutationNAK444*0.2
STADchr1157795607Missense_MutationNAP100T0.18
STADchr1157811477Frame_Shift_InsnovelS879Ifs*30.31
STADchr1157808292Splice_RegionNAT697T0.18
STADchr1157805905SilentNAL582L0.21
STADchr1157814325Missense_Mutationrs369783710R885W0.13
STADchr1157802037Frame_Shift_DelnovelK422Rfs*260.22
STADchr1157804695Missense_Mutationrs552330982R546Q0.5
STADchr1157808292Splice_RegionNAT697T0.32
STADchr1157796859Missense_MutationNAF275L0.17
STADchr1157806917Frame_Shift_DelNAK634Nfs*30.33
STADchr1157810192Frame_Shift_DelNAE842Kfs*100.16
STADchr1157803668Missense_MutationNAV490M0.41
STADchr1157802117Frame_Shift_DelNAN449Tfs*490.2
THCAchr1157805988Missense_MutationNAN610T0.08
UCECchr1157815921Missense_Mutationrs763409650E939K0.49
UCECchr1157804698Frame_Shift_InsNAR549Tfs*50.71
UCECchr11578166863'UTRnovel0.5
UCECchr1157791595Silentrs767908593A39A0.28
UCECchr1157796458Missense_MutationnovelV141A0.31
UCECchr1157801837Missense_Mutationrs754613241R354H0.3
UCECchr1157802118Missense_MutationNAK448Q0.42
UCECchr1157794057SilentnovelS81S0.16
UCECchr1157794082Splice_SiteNAX89_splice0.42
UCECchr1157794074Missense_MutationnovelG87E0.29
UCECchr1157796680Missense_Mutationrs376380308R215H0.65
UCECchr1157808198Missense_MutationNAR666Q0.28
UCECchr1157809302Missense_MutationNAK757N0.35
UCECchr1157809281SilentnovelH750H0.51
UCECchr11578180213'UTRnovel0.29
UCECchr1157810197Nonsense_MutationNAE842*0.38
UCECchr1157808531Nonsense_MutationNAE745*0.38
UCECchr1157795716Missense_MutationnovelR136H0.36
UCECchr1157802149Missense_MutationnovelR458Q0.37
UCECchr1157805965Missense_MutationnovelE602D0.38
UCECchr1157803646SilentnovelH482H0.28
UCECchr1157796857Missense_Mutationrs762340314R274H0.43
UCECchr1157801985Silentrs541781874D403D0.44
UCECchr1157806970Silentrs368183000T650T0.34
UCECchr1157802158Missense_MutationNAR461Q0.31
UCECchr11578165703'UTRnovel0.24
UCECchr1157796577Missense_MutationNAD181Y0.22
UCECchr1157801832SilentNAS352S0.23
UCECchr1157805947Missense_MutationNAQ596H0.18
UCECchr1157806952SilentNAV644V0.27
UCECchr1157808389Splice_SiteNAX698_splice0.4
UCECchr1157808446In_Frame_InsnovelA716_D717insLPL0.06
UCECchr1157802017Missense_MutationNAV414A0.07
UCECchr11578182573'UTRnovel0.46
UCECchr1157808172Missense_MutationNAE657D0.19
UCECchr1157810114Missense_Mutationrs376382187R814H0.31
UCECchr1157795659Missense_MutationnovelP117H0.41
UCECchr1157796826Missense_Mutationrs770665127R264W0.36
UCECchr1157795730Splice_SitenovelX140_splice0.19
UCECchr1157805966Missense_MutationnovelA603S0.1
UCECchr1157808531Nonsense_MutationNAE745*0.18
UCECchr1157802000Missense_MutationNAK408N0.32
UCECchr1157803756Missense_Mutationrs758420026R519H0.05
UCECchr1157808520Missense_MutationnovelA741V0.32
UCECchr1157796986Missense_Mutationrs764156809R317H0.37
UCECchr1157805988Missense_MutationNAN610T0.29
UCECchr11578171243'UTRnovel0.48
UCECchr11578185663'UTRnovel0.57
UCECchr1157810131Nonsense_MutationNAR820*0.27
UCECchr1157795648SilentnovelT113T0.08
UCECchr1157805910Missense_MutationnovelR584Q0.3
UCECchr1157815454Missense_MutationnovelG921E0.33
UCECchr11578169603'UTRnovel0.42
UCECchr1157802117Frame_Shift_DelNAN449Tfs*490.23
UCECchr1157795648SilentnovelT113T0.47
UCECchr1157808406Missense_Mutationrs750954167R703H0.42
UCECchr1157808523Missense_Mutationrs201606412R742H0.28
UCECchr1157808499Missense_MutationnovelL734P0.38
UCECchr11578180793'UTRnovel0.43
UCECchr1157809308Silentrs376307021L759L0.45
UCECchr1157796767Missense_MutationNAS244N0.29
UCECchr1157802092Missense_Mutationrs759024257R439H0.16
UCECchr1157815421Missense_MutationnovelR910I0.45
UCECchr11578175723'UTRrs115382880.56
UCECchr1157796781Missense_MutationNAR249W0.46
UCECchr1157802157Nonsense_MutationNAR461*0.34
UCECchr1157802158Missense_MutationNAR461Q0.38
UCECchr1157806033Missense_MutationnovelK625T0.4
UCECchr1157796929Missense_MutationnovelM298T0.37
UCECchr1157809387Missense_MutationnovelI786F0.4
UCECchr1157810129Missense_MutationnovelV819A0.22
UCECchr1157803756Missense_Mutationrs758420026R519H0.25
UCECchr1157811482Missense_MutationnovelK878N0.43
UCECchr11578182573'UTRnovel0.57
UCECchr1157803756Missense_Mutationrs758420026R519H0.46
UCECchr1157791663Missense_MutationNAR62H0.1
UCECchr1157811468Missense_MutationnovelD874N0.11
UCECchr1157805955Missense_Mutationrs777009146R599H0.4
UCECchr1157806944Missense_Mutationrs775196396D642N0.72
UCECchr1157808488SilentnovelA730A0.49
UCECchr11578172413'UTRrs5608332970.33
UCECchr11577914265'UTRnovel0.17
UCECchr1157803799SilentnovelC533C0.33
UCECchr11578165703'UTRnovel0.48
UCECchr1157802198Splice_SitenovelX474_splice0.1
UCECchr1157814317Missense_MutationnovelK882T0.13
UCECchr1157815593Intronnovel0.15
UCECchr1157794073Missense_Mutationrs776716629G87R0.45
UCECchr1157802196Missense_MutationnovelG474R0.26
UCECchr1157805923Nonsense_MutationNAY588*0.2
UCECchr1157791606Missense_MutationnovelR43H0.33
UCECchr11578177593'UTRnovel0.31
UCECchr1157806961Frame_Shift_DelnovelR649Efs*330.33
UCECchr1157815465Missense_MutationNAD925N0.3
UCECchr1157796827Missense_MutationNAR264Q0.07
UCECchr11578169863'UTRnovel0.62
UCECchr1157808531Nonsense_MutationNAE745*0.38
UCECchr1157794048Missense_MutationNAQ78H0.31
UCECchr1157796983Missense_MutationnovelR316Q0.49
UCECchr1157804704Missense_Mutationrs777282942R549Q0.34
UCECchr1157805909Missense_Mutationrs780642639R584W0.41
UCECchr1157806458Splice_Regionnovel0.29
UCECchr1157810164Nonsense_MutationNAG831*0.19
UCECchr1157815412Missense_MutationnovelP907R0.2
UCECchr1157802126Missense_MutationnovelC450W0.06
UCECchr1157808225Missense_MutationNAS675N0.3
UCECchr1157808456Missense_Mutationrs781385866T720A0.28
UCECchr1157796823Missense_MutationnovelV263I0.4
UCECchr1157802167Missense_Mutationrs763306444R464H0.35
UCECchr11578164713'UTRnovel0.37
UCECchr1157804692Missense_MutationNAR545H0.33
UCSchr1157806036Splice_SitenovelX626_splice0.35

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.15760.018342
TGCTDEL0.64670.21504

Survival Analysis
CancerP-value Q-value
THYM0.0071

Kaplan-Meier Survival Analysis

ACC0.0023

Kaplan-Meier Survival Analysis

TGCT0.045

Kaplan-Meier Survival Analysis

PAAD0.00011

Kaplan-Meier Survival Analysis

PCPG0.02

Kaplan-Meier Survival Analysis

READ0.0041

Kaplan-Meier Survival Analysis

LAML0.012

Kaplan-Meier Survival Analysis

LGG0.0023

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000198561 (Gene tree)
Gene ID
1500
Gene Symbol
CTNND1
Alias
KIAA0384|p120|p120cas|p120ctn|CTNND
Full Name
catenin delta 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
66,304 bases
Position
chr11:57,753,243-57,819,546
Accession
2515
RBP type
non-canonical RBP
Summary
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
11029582Structural domains involved in the RNA folding activity of RNA helicase II/Gu protein.Eur J Biochem2000 NovValdez BC-
19829082The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events.RNA Biol2009 Nov-DecWarzecha CC-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000530094CTNND1-2255814-ENSP00000437327861 (aa)-O60716
ENST00000527599CTNND1-217572--- (aa)--
ENST00000531007CTNND1-228848-ENSP00000431208123 (aa)-H0YC95
ENST00000530748CTNND1-2275925-ENSP00000436744885 (aa)-O60716
ENST00000361391CTNND1-2036232-ENSP00000354785941 (aa)-O60716
ENST00000426142CTNND1-2075800-ENSP00000409930832 (aa)-O60716
ENST00000532844CTNND1-2346012-ENSP00000433276914 (aa)-O60716
ENST00000361796CTNND1-2046226-ENSP00000354907939 (aa)-O60716
ENST00000428599CTNND1-2086016-ENSP00000413586933 (aa)-O60716
ENST00000361332CTNND1-2026295-ENSP00000354823962 (aa)-O60716
ENST00000525821CTNND1-211545--- (aa)--
ENST00000529986CTNND1-2235727-ENSP00000437156832 (aa)-O60716
ENST00000526772CTNND1-2144966-ENSP00000433158610 (aa)-O60716
ENST00000527467CTNND1-2165071-ENSP00000434900645 (aa)-O60716
ENST00000524579CTNND1-209505-ENSP000004322994 (aa)-UPI0001F77C29
ENST00000532787CTNND1-2335751-ENSP00000434949840 (aa)-O60716
ENST00000399050CTNND1-2056313-ENSP00000382004968 (aa)-O60716
ENST00000415361CTNND1-2065832-ENSP00000403518867 (aa)-O60716
ENST00000532245CTNND1-2305655-ENSP00000434017832 (aa)-O60716
ENST00000531014CTNND1-2295053-ENSP00000432623639 (aa)-O60716
ENST00000526938CTNND1-2153489-ENSP00000432041918 (aa)-O60716
ENST00000530068CTNND1-224579-ENSP00000431600128 (aa)-E9PKL1
ENST00000533189CTNND1-235498-ENSP00000435242126 (aa)-E9PKY0
ENST00000534579CTNND1-2376024-ENSP00000435789879 (aa)-O60716
ENST00000358694CTNND1-2016135-ENSP00000351527933 (aa)-O60716
ENST00000533667CTNND1-2364990-ENSP00000437051618 (aa)-O60716
ENST00000532649CTNND1-2326026-ENSP00000435379879 (aa)-O60716
ENST00000528621CTNND1-2195907-ENSP00000432243879 (aa)-O60716
ENST00000532463CTNND1-2315749-ENSP00000432075832 (aa)-O60716
ENST00000530720CTNND1-226832--- (aa)--
ENST00000529526CTNND1-2206099-ENSP00000436323879 (aa)-O60716
ENST00000528232CTNND1-2185745-ENSP00000435266838 (aa)-O60716
ENST00000525902CTNND1-2124984-ENSP00000434672616 (aa)-O60716
ENST00000524630CTNND1-2106553-ENSP00000436543933 (aa)-O60716
ENST00000529873CTNND1-2215931-ENSP00000435494887 (aa)-O60716
ENST00000534647CTNND1-238866-ENSP00000434202261 (aa)-E9PRE2
ENST00000529919CTNND1-2224780-ENSP00000434808938 (aa)-C9JZR2
ENST00000526357CTNND1-2135994-ENSP00000433334908 (aa)-O60716
Gene Model
Click here to download ENSG00000198561's gene model file
Pathways
Pathway IDPathway NameSource
hsa04015Rap1 signaling pathwayKEGG
hsa04520Adherens junctionKEGG
hsa04670Leukocyte transendothelial migrationKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000198561rs37818851157803208?General cognitive ability29844566z-score decrease4.709EFO_0004337
ENSG00000198561rs37818851157803208TWorry too long after an embarrassing experience29500382z score increase6.77EFO_0009589
ENSG00000198561rs4869951157753756?Systolic blood pressure30595370EFO_0006335
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198561's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000198561CTNND110097.712ENSMUSG00000034101Ctnnd110097.712Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005102signaling receptor binding19332538.IPIFunction
GO:0005515protein binding12370829.12475979.15657067.16354688.17047063.20123964.22846708.23990464.24189400.24658140.28051089.28877994.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus20123964.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm17047063.IDAComponent
GO:0005829cytosol20123964.IMPComponent
GO:0005886plasma membrane21873635.IBAComponent
GO:0005886plasma membrane17115030.IDAComponent
GO:0005886plasma membrane20123964.IMPComponent
GO:0005886plasma membrane-TASComponent
GO:0005911cell-cell junction21873635.IBAComponent
GO:0005911cell-cell junction12370829.IDAComponent
GO:0005913cell-cell adherens junction21873635.IBAComponent
GO:0005915zonula adherens-IEAComponent
GO:0007043cell-cell junction assembly21873635.IBAProcess
GO:0007155cell adhesion8808291.NASProcess
GO:0007420brain development-IEAProcess
GO:0016055Wnt signaling pathway-IEAProcess
GO:0016342catenin complex28051089.IDAComponent
GO:0019901protein kinase binding-IEAFunction
GO:0030027lamellipodium-IEAComponent
GO:0030426growth cone-IEAComponent
GO:0030496midbody15166316.IDAComponent
GO:0034332adherens junction organization-TASProcess
GO:0035635entry of bacterium into host cell-TASProcess
GO:0043197dendritic spine-IEAComponent
GO:0045296cadherin binding25468996.HDAFunction
GO:0045296cadherin binding21873635.IBAFunction
GO:0045296cadherin binding12734196.IPIFunction
GO:0070062extracellular exosome19199708.HDAComponent
GO:0090090negative regulation of canonical Wnt signaling pathway20123964.IMPProcess
GO:0098609cell-cell adhesion21873635.IBAProcess
GO:0098685Schaffer collateral - CA1 synapse-IEAComponent
GO:0098686hippocampal mossy fiber to CA3 synapse-IEAComponent
GO:0098831presynaptic active zone cytoplasmic component-IEAComponent
GO:0098978glutamatergic synapse-IEAComponent
GO:0099072regulation of postsynaptic membrane neurotransmitter receptor levels18602475.EXPProcess
GO:0099072regulation of postsynaptic membrane neurotransmitter receptor levels18602475.IDAProcess
GO:0099092postsynaptic density, intracellular component-IEAComponent
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