EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18381799	BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility.	J Rheumatol	2008 May	Quiones-Lombraa A	-
30176153	DDX39B promotes translation through regulation of pre-ribosomal RNA levels.	RNA Biol	2018	Awasthi S	doi: 10.1080/15476286.2018.1517011

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr6	31531163	Nonsense_Mutation	NA	R338*	0.18
BLCA	chr6	31532882	Silent	NA	T255T	0.27
BLCA	chr6	31535409	Missense_Mutation	NA	L231F	0.19
BLCA	chr6	31536431	Intron	novel		0.18
BLCA	chr6	31532838	Missense_Mutation	novel	K270T	0.3
BLCA	chr6	31540451	Missense_Mutation	NA	E28K	0.13
BLCA	chr6	31541202	Intron	novel		0.18
BLCA	chr6	31530869	Missense_Mutation	NA	E394K	0.18
BLCA	chr6	31532922	Intron	novel		0.12
BLCA	chr6	31541217	Intron	novel		0.15
BLCA	chr6	31539040	Intron	novel		0.11
BRCA	chr6	31531101	Silent	NA	I358I	0.34
BRCA	chr6	31542419	5'UTR	novel		0.2
BRCA	chr6	31535154	Intron	novel		0.65
BRCA	chr6	31532822	Missense_Mutation	novel	N275K	0.05
BRCA	chr6	31540920	Intron	novel		0.39
CESC	chr6	31541030	Intron	novel		0.44
CESC	chr6	31530923	Missense_Mutation	novel	A376S	0.37
CESC	chr6	31531486	Intron	novel		0.15
CHOL	chr6	31534266	Intron	novel		0.47
COAD	chr6	31535186	Intron	novel		0.47
COAD	chr6	31541264	Intron	novel		0.17
COAD	chr6	31541264	Intron	novel		0.22
COAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.44
COAD	chr6	31541264	Intron	novel		0.41
COAD	chr6	31541264	Intron	novel		0.77
COAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.24
COAD	chr6	31534515	Intron	NA		0.43
COAD	chr6	31534531	Intron	novel		0.26
COAD	chr6	31541264	Intron	novel		0.43
COAD	chr6	31534624	Intron	novel		0.78
COAD	chr6	31534531	Intron	novel		0.23
COAD	chr6	31541264	Intron	novel		0.41
COAD	chr6	31534530	Intron	novel		0.17
COAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.3
COAD	chr6	31540964	Intron	novel		0.3
COAD	chr6	31531162	Missense_Mutation	NA	R338Q	0.26
COAD	chr6	31541264	Intron	novel		0.27
COAD	chr6	31531502	Intron	novel		0.6
COAD	chr6	31534531	Intron	novel		0.45
COAD	chr6	31534480	Intron	novel		0.27
COAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.22
COAD	chr6	31531160	Nonsense_Mutation	NA	R339*	0.26
COAD	chr6	31530262	3'UTR	rs3219189		0.44
COAD	chr6	31530804	Silent	NA	P415P	0.21
ESCA	chr6	31535327	Intron	rs145191873		0.18
GBM	chr6	31540377	Silent	NA	L52L	0.22
GBM	chr6	31532898	Missense_Mutation	novel	F250C	0.19
HNSC	chr6	31536393	Intron	novel		0.11
KIRC	chr6	31539247	Missense_Mutation	NA	I80T	0.27	ResIII
KIRC	chr6	31536585	Frame_Shift_Ins	novel	A178*	0.23
KIRC	chr6	31541892	Intron	novel		0.38
KIRP	chr6	31539265	Missense_Mutation	NA	E74G	0.44	ResIII
KIRP	chr6	31541485	Intron	novel		0.45
LAML	chr6	31540553	5'UTR	novel		0.04
LAML	chr6	31541205	Intron	novel		0.12
LGG	chr6	31538841	Silent	NA	V118V	0.11
LGG	chr6	31540489	Missense_Mutation	NA	D15G	0.13
LIHC	chr6	31541723	Intron	novel		0.36
LIHC	chr6	31539230	Missense_Mutation	novel	L86V	0.51	ResIII
LIHC	chr6	31532784	Missense_Mutation	rs745700709	N288S	0.44
LUAD	chr6	31532803	Silent	novel	L282L	0.39
LUAD	chr6	31530827	Missense_Mutation	novel	E408Q	0.1
LUAD	chr6	31535339	Intron	novel		0.08
LUAD	chr6	31540358	Missense_Mutation	novel	A59S	0.23
LUAD	chr6	31531150	Missense_Mutation	novel	V342A	0.61
LUAD	chr6	31531298	Missense_Mutation	novel	E325D	0.3
LUAD	chr6	31530783	Silent	novel	S422S	0.4
LUAD	chr6	31531054	Missense_Mutation	novel	R374Q	0.07
LUAD	chr6	31532882	Silent	NA	T255T	0.17
LUAD	chr6	31536393	Intron	novel		0.41
LUAD	chr6	31539272	Nonsense_Mutation	novel	Q72*	0.19	ResIII
LUAD	chr6	31540519	Missense_Mutation	NA	D5A	0.21
LUSC	chr6	31536579	Silent	novel	L179L	0.25
LUSC	chr6	31530882	Silent	NA	T389T	0.38
LUSC	chr6	31539275	Splice_Site	novel	X71_splice	0.05
LUSC	chr6	31530852	Missense_Mutation	novel	I399M	0.13
LUSC	chr6	31540583	5'UTR	novel		0.35
LUSC	chr6	31532813	Silent	novel	L278L	0.25
LUSC	chr6	31532920	Intron	novel		0.28
OV	chr6	31541263	Intron	novel		0.25
OV	chr6	31530803	Missense_Mutation	NA	D416H	0.29
OV	chr6	31541097	Intron	novel		0.07
PAAD	chr6	31530873	Silent	rs747572088	S392S	0.18
PAAD	chr6	31531332	Missense_Mutation	novel	A314V	0.04
PRAD	chr6	31541264	Intron	novel		0.3
PRAD	chr6	31531386	Missense_Mutation	novel	S296C	0.18
PRAD	chr6	31540447	Missense_Mutation	novel	A29G	0.29
READ	chr6	31541264	Intron	novel		0.43
READ	chr6	31541325	Intron	novel		0.26
READ	chr6	31535254	Intron	novel		0.36
READ	chr6	31536517	Missense_Mutation	novel	K200T	0.41
READ	chr6	31540524	Silent	novel	E3E	0.39
SARC	chr6	31542065	5'UTR	novel		0.06
SKCM	chr6	31531463	Intron	novel		0.44
SKCM	chr6	31531321	Missense_Mutation	NA	H318Y	0.17
SKCM	chr6	31531424	Intron	novel		0.35
SKCM	chr6	31535314	Intron	novel		0.29
SKCM	chr6	31541215	Intron	novel		0.63
SKCM	chr6	31531300	Missense_Mutation	NA	E325K	0.57
SKCM	chr6	31540451	Missense_Mutation	NA	E28K	0.43
SKCM	chr6	31532822	Missense_Mutation	NA	N275K	0.64
SKCM	chr6	31535314	Intron	novel		0.22
SKCM	chr6	31535330	Intron	rs201097551		0.2
SKCM	chr6	31532927	Intron	novel		0.5
SKCM	chr6	31535358	Intron	novel		0.4
SKCM	chr6	31532806	Missense_Mutation	novel	L281F	0.27
SKCM	chr6	31532807	Silent	novel	D280D	0.29
SKCM	chr6	31530933	Splice_Region	rs765334216		0.28
SKCM	chr6	31536391	Intron	novel		0.15
SKCM	chr6	31536598	Missense_Mutation	NA	P173L	0.29
SKCM	chr6	31540357	Missense_Mutation	novel	A59V	0.25
SKCM	chr6	31540382	Silent	NA	L51L	0.68
SKCM	chr6	31530933	Splice_Region	rs765334216		0.33
SKCM	chr6	31530423	3'UTR	rs766548140		0.13
SKCM	chr6	31540557	5'UTR	novel		0.19
STAD	chr6	31541271	Intron	novel		0.22
STAD	chr6	31532897	Silent	rs774073722	F250F	0.37
STAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.28
STAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.18
STAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.27
STAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.18
STAD	chr6	31541264	Intron	novel		0.29
STAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.19
STAD	chr6	31541264	Intron	novel		0.32
STAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.25
STAD	chr6	31540368	Missense_Mutation	novel	E55D	0.15
STAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.41
STAD	chr6	31541175	Intron	rs373928218		0.15
STAD	chr6	31541264	Intron	novel		0.26
STAD	chr6	31536405	Intron	novel		0.38
STAD	chr6	31541264	Intron	novel		0.21
STAD	chr6	31539147	Splice_Region	novel	Q113Q	0.06
STAD	chr6	31541264	Intron	novel		0.17
STAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.24
STAD	chr6	31541177	Intron	novel		0.24
STAD	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.42
STAD	chr6	31538947	Intron	rs752036348		0.12
THYM	chr6	31541870	Intron	novel		0.1
THYM	chr6	31541145	Intron	novel		0.3
UCEC	chr6	31539162	Silent	novel	E108E	0.49
UCEC	chr6	31540506	Missense_Mutation	novel	E9D	0.18
UCEC	chr6	31531154	Missense_Mutation	NA	L341I	0.21
UCEC	chr6	31540456	Missense_Mutation	novel	G26E	0.46
UCEC	chr6	31535187	Intron	novel		0.56
UCEC	chr6	31530443	Silent	novel	Q426Q	0.45
UCEC	chr6	31541593	Intron	novel		0.09
UCEC	chr6	31542223	5'UTR	novel		0.05
UCEC	chr6	31541845	Intron	novel		0.33
UCEC	chr6	31535309	Intron	novel		0.31
UCEC	chr6	31541264	Intron	novel		0.5
UCEC	chr6	31535306	Intron	NA		0.85
UCEC	chr6	31540486	Missense_Mutation	novel	D16A	0.25
UCEC	chr6	31542310	5'UTR	novel		0.11
UCEC	chr6	31540485	Silent	novel	D16D	0.47
UCEC	chr6	31541264	Intron	novel		0.55
UCEC	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.36
UCEC	chr6	31541264	Intron	novel		0.42
UCEC	chr6	31534515	Intron	NA		0.3
UCEC	chr6	31540957	Intron	novel		0.38
UCEC	chr6	31536603	Silent	rs190488922	G171G	0.49
UCEC	chr6	31541827	Intron	novel		0.57
UCEC	chr6	31530855	Missense_Mutation	novel	K398N	0.6
UCEC	chr6	31542225	5'UTR	novel		0.41
UCEC	chr6	31532991	Intron	novel		0.71
UCEC	chr6	31538998	Intron	rs139648127		0.21
UCEC	chr6	31531154	Missense_Mutation	NA	L341I	0.46
UCEC	chr6	31532897	Silent	rs774073722	F250F	0.47
UCEC	chr6	31535456	Missense_Mutation	rs267600954	R216C	0.25
UCEC	chr6	31542225	5'UTR	novel		0.42
UCEC	chr6	31535330	Intron	rs201097551		0.38
UCEC	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.27
UCEC	chr6	31535127	Intron	rs566742475		0.25
UCEC	chr6	31535268	Intron	novel		0.61
UCEC	chr6	31538840	Missense_Mutation	novel	M119L	0.37
UCEC	chr6	31536669	Frame_Shift_Del	NA	*F149Lfs13**	0.28
UCEC	chr6	31530378	3'UTR	novel		0.33
UCEC	chr6	31531130	Nonsense_Mutation	NA	R349*	0.11
UCEC	chr6	31530424	3'UTR	novel		0.24
UCEC	chr6	31530910	Missense_Mutation	novel	R380Q	0.16
UCEC	chr6	31540965	Intron	novel		0.36
UCEC	chr6	31532873	Silent	rs539629605	T258T	0.33
UCEC	chr6	31535444	Frame_Shift_Del	NA	*H220Tfs6**	0.3
UCEC	chr6	31540465	Missense_Mutation	NA	G23E	0.23
UCEC	chr6	31534624	Intron	novel		0.42
UCEC	chr6	31530878	Missense_Mutation	novel	V391L	0.5
UCEC	chr6	31535262	Intron	rs745906288		0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.1042	0.011841

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
SARC	0.022	Kaplan-Meier Survival Analysis
ACC	0.033	Kaplan-Meier Survival Analysis
HNSC	0.018	Kaplan-Meier Survival Analysis
PRAD	0.019	Kaplan-Meier Survival Analysis
COAD	0.0042	Kaplan-Meier Survival Analysis
PCPG	0.0057	Kaplan-Meier Survival Analysis
BLCA	0.0001	Kaplan-Meier Survival Analysis
CESC	0.023	Kaplan-Meier Survival Analysis
READ	0.028	Kaplan-Meier Survival Analysis
UCEC	0.006	Kaplan-Meier Survival Analysis
GBM	0.016	Kaplan-Meier Survival Analysis
LIHC	0.038	Kaplan-Meier Survival Analysis
THCA	0.017	Kaplan-Meier Survival Analysis
LUAD	0.029	Kaplan-Meier Survival Analysis

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000198563 (Gene tree)
Gene ID: 7919
Gene Symbol: DDX39B
Alias: D6S81E|UAP56|BAT1
Full Name: DExD-box helicase 39B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 12,257 bases
Position: chr6:31,530,219-31,542,475
Accession: 13917
RBP type: canonical RBP
Summary: This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000410313	ResIII	PF04851.15	1.4e-07	1	1
ENSP00000392672	ResIII	PF04851.15	1.5e-07	1	1
ENSP00000399371	ResIII	PF04851.15	2.2e-07	1	1
ENSP00000416350	ResIII	PF04851.15	2.9e-07	1	1
ENSP00000379475	ResIII	PF04851.15	4.8e-07	1	1
ENSP00000416269	ResIII	PF04851.15	4.8e-07	1	1
ENSP00000365347	ResIII	PF04851.15	5e-07	1	1
ENSP00000392672	DEAD	PF00270.29	7.6e-39	1	1
ENSP00000399371	DEAD	PF00270.29	1.3e-38	1	1
ENSP00000410313	DEAD	PF00270.29	1.3e-38	1	1
ENSP00000379475	DEAD	PF00270.29	2.5e-38	1	1
ENSP00000416269	DEAD	PF00270.29	2.5e-38	1	1
ENSP00000365347	DEAD	PF00270.29	2.8e-38	1	1
ENSP00000416350	DEAD	PF00270.29	9.8e-38	1	1
ENSP00000408000	DEAD	PF00270.29	6.9e-19	1	1
ENSP00000409426	DEAD	PF00270.29	5.1e-16	1	1
ENSP00000405707	DEAD	PF00270.29	2e-15	1	1
ENSP00000393984	DEAD	PF00270.29	3.2e-09	1	1
ENSP00000399841	DEAD	PF00270.29	1.6e-07	1	1
ENSP00000405245	DEAD	PF00270.29	2.9e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16500893	RNA-binding of the human cytomegalovirus transactivator protein UL69, mediated by arginine-rich motifs, is not required for nuclear export of unspliced RNA.	Nucleic Acids Res	2006 Feb 25	Toth Z	-
18722339	Isolation and characterization of Plasmodium falciparum UAP56 homolog: evidence for the coupling of RNA binding and splicing activity by site-directed mutations.	Arch Biochem Biophys	2008 Oct 15	Shankar J	doi: 10.1016/j.abb.2008.07.027
29070793	Cellular splicing factor UAP56 stimulates trimeric NP formation for assembly of functional influenza viral ribonucleoprotein complexes.	Sci Rep	2017 Oct 25	Hu Y	doi: 10.1038/s41598-017-13784-4.
30258431	The Cellular DExD/H-Box RNA Helicase UAP56 Co-localizes With the Influenza A Virus NS1 Protein.	Front Microbiol	2018 Sep 12	Chiba S	doi: 10.3389/fmicb.2018.02192
10343160	Characterisation of the human central MHC gene, BAT1: genomic structure and expression.	Exp Clin Immunogenet	1999	Allcock RJ	-
17984224	ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56.	Mol Cell Biol	2008 Jan	Taniguchi I	-
17251556	Multimerization of human cytomegalovirus regulatory protein UL69 via a domain that is conserved within its herpesvirus homologues.	J Gen Virol	2007 Feb	Lischka P	-
26178996	pUL69 of Human Cytomegalovirus Recruits the Cellular Protein Arginine Methyltransferase 6 via a Domain That Is Crucial for mRNA Export and Efficient Viral Replication.	J Virol	2015 Sep	Thomas M	doi: 10.1128/JVI.01399-15
11156602	Identification and characterization of yUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56.	Genes Dev	2001 Jan 1	Zhang M	-
18411249	Binding of ATP to UAP56 is necessary for mRNA export.	J Cell Sci	2008 May 1	Kota KP	doi: 10.1242/jcs.021055
30700540	The UAP56-Interacting Export Factors UIEF1 and UIEF2 Function in mRNA Export.	Plant Physiol	2019 Apr	Ehrnsberger HF	doi: 10.1104/pp.18.01476

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000462256	DDX39B-215	4027	-	-	- (aa)	-	-
ENST00000481456	DDX39B-219	5158	-	-	- (aa)	-	-
ENST00000376177	DDX39B-201	1529	-	ENSP00000365347	425 (aa)	-	Q5STU3
ENST00000474961	DDX39B-217	974	-	-	- (aa)	-	-
ENST00000484566	DDX39B-221	857	-	ENSP00000436220	141 (aa)	-	H0YCC6
ENST00000456976	DDX39B-213	720	-	ENSP00000393984	125 (aa)	-	F6U6E2
ENST00000458640	DDX39B-214	2003	-	ENSP00000416269	428 (aa)	-	Q13838
ENST00000456662	DDX39B-212	932	-	ENSP00000416350	231 (aa)	-	F6S4E6
ENST00000419338	DDX39B-206	928	-	ENSP00000410313	235 (aa)	-	A0A0A0MT12
ENST00000428450	DDX39B-209	633	-	ENSP00000405707	197 (aa)	-	F6R6M7
ENST00000417023	DDX39B-203	561	-	ENSP00000406422	187 (aa)	-	H0Y400
ENST00000449757	DDX39B-211	591	-	ENSP00000409426	187 (aa)	-	F6QYI9
ENST00000428098	DDX39B-208	817	-	ENSP00000392672	238 (aa)	-	F6TRA5
ENST00000478365	DDX39B-218	439	-	-	- (aa)	-	-
ENST00000431908	DDX39B-210	914	-	ENSP00000408000	245 (aa)	-	F6UJC5
ENST00000482195	DDX39B-220	1232	-	-	- (aa)	-	-
ENST00000419020	DDX39B-205	583	-	ENSP00000405245	132 (aa)	-	F6S2B7
ENST00000462421	DDX39B-216	618	-	-	- (aa)	-	-
ENST00000396172	DDX39B-202	2133	-	ENSP00000379475	428 (aa)	-	Q13838
ENST00000418897	DDX39B-204	583	-	ENSP00000399841	136 (aa)	-	F6SXL5
ENST00000427214	DDX39B-207	1005	-	ENSP00000399371	289 (aa)	-	F6WLT2

Gene Model

Click here to download ENSG00000198563's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa03015	mRNA surveillance pathway	KEGG
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000198563	Breast Neoplasms	2.459E-13	17660530
ENSG00000198563	Diabetes Mellitus, Type 1	5.29E-68	19430480
ENSG00000198563	Behcet Syndrome	4.55942540272892E-05	20622878
ENSG00000198563	Behcet Syndrome	5.97381407474203E-06	20622878
ENSG00000198563	Behcet Syndrome	8.82169288626833E-07	20622878
ENSG00000198563	Behcet Syndrome	8.71917049005456E-07	20622878
ENSG00000198563	Behcet Syndrome	1.03078253218308E-06	20622878
ENSG00000198563	Behcet Syndrome	8.82169288626833E-07	20622878
ENSG00000198563	Behcet Syndrome	1.0729589781576E-06	20622878
ENSG00000198563	Behcet Syndrome	6.22624609680527E-07	20622878
ENSG00000198563	Platelet Function Tests	8.1800000E-006	-
ENSG00000198563	Stevens-Johnson Syndrome	2E-8	21912425
ENSG00000198563	Dermatitis, Atopic	2E-6	22197932

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198563	rs2269476	6	31540161	A	Mean platelet volume	27863252	[0.039-0.057] unit increase	0.04806173	EFO_0004584
ENSG00000198563	rs114050967	6	31537703	G	Myositis	26291516	[NR]	2.32	EFO_0000783
ENSG00000198563	rs9267485	6	31538013	G	Mosquito bite size	28199695	[0.041-0.065] unit decrease	0.0531442	EFO_0008378
ENSG00000198563	rs34788230	6	31540676	G	Monocyte percentage of white cells	27863252	[0.02-0.034] unit decrease	0.02679379	EFO_0007989
ENSG00000198563	rs2734583	6	31537703	?	Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN)	21912425	[19.8-225.0]	66.8	EFO_0004276\|EFO_0004775
ENSG00000198563	rs3853601	6	31531826	G	Atopic dermatitis	22197932	[1.08-1.19]	1.13	EFO_0000274

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198563's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000198563	DDX39B	78	30.256	ENSG00000111364	DDX55	85	31.902
ENSG00000198563	DDX39B	100	89.953	ENSG00000123136	DDX39A	100	89.953
ENSG00000198563	DDX39B	91	32.832	ENSG00000157349	DDX19B	98	33.243
ENSG00000198563	DDX39B	80	38.095	ENSG00000124228	DDX27	88	31.837
ENSG00000198563	DDX39B	86	32.367	ENSG00000198231	DDX42	51	30.685
ENSG00000198563	DDX39B	81	32.821	ENSG00000136271	DDX56	88	35.976
ENSG00000198563	DDX39B	96	38.547	ENSG00000110367	DDX6	79	35.659
ENSG00000198563	DDX39B	83	31.120	ENSG00000123064	DDX54	91	32.812
ENSG00000198563	DDX39B	95	31.351	ENSG00000109832	DDX25	94	40.625
ENSG00000198563	DDX39B	84	32.922	ENSG00000213782	DDX47	75	35.159
ENSG00000198563	DDX39B	91	36.257	ENSG00000156976	EIF4A2	79	50.000
ENSG00000198563	DDX39B	91	36.842	ENSG00000141543	EIF4A3	88	38.356
ENSG00000198563	DDX39B	93	30.387	ENSG00000118197	DDX59	79	30.387
ENSG00000198563	DDX39B	80	30.612	ENSG00000278053	DDX52	50	41.379
ENSG00000198563	DDX39B	92	37.687	ENSG00000161960	EIF4A1	95	41.406
ENSG00000198563	DDX39B	87	36.053	ENSG00000064703	DDX20	51	39.437
ENSG00000198563	DDX39B	91	32.581	ENSG00000168872	DDX19A	95	33.246
ENSG00000198563	DDX39B	87	31.759	ENSG00000105671	DDX49	71	39.241
ENSG00000198563	DDX39B	77	30.029	ENSG00000108654	DDX5	70	30.081
ENSG00000198563	DDX39B	99	30.116	ENSG00000215301	DDX3X	79	30.052

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000198563	DDX39B	100	99.766	ENSAMEG00000009508	DDX39B	99	99.766	Ailuropoda_melanoleuca
ENSG00000198563	DDX39B	99	93.677	ENSACIG00000004534	ddx39b	98	93.677	Amphilophus_citrinellus
ENSG00000198563	DDX39B	100	92.824	ENSATEG00000012366	ddx39b	100	92.824	Anabas_testudineus
ENSG00000198563	DDX39B	100	97.203	ENSACAG00000012240	DDX39B	100	97.203	Anolis_carolinensis
ENSG00000198563	DDX39B	100	100.000	ENSANAG00000030372	DDX39B	100	100.000	Aotus_nancymaae
ENSG00000198563	DDX39B	95	95.506	ENSACLG00000018759	ddx39b	99	90.783	Astatotilapia_calliptera
ENSG00000198563	DDX39B	100	92.431	ENSAMXG00000017837	ddx39b	100	92.431	Astyanax_mexicanus
ENSG00000198563	DDX39B	100	100.000	ENSBTAG00000014490	DDX39B	100	99.766	Bos_taurus
ENSG00000198563	DDX39B	100	100.000	ENSCJAG00000003152	DDX39B	100	100.000	Callithrix_jacchus
ENSG00000198563	DDX39B	100	99.533	ENSCAFG00000000509	DDX39B	100	100.000	Canis_familiaris
ENSG00000198563	DDX39B	100	99.533	ENSCAFG00020020530	DDX39B	100	99.533	Canis_lupus_dingo
ENSG00000198563	DDX39B	100	100.000	ENSCHIG00000004579	DDX39B	100	99.766	Capra_hircus
ENSG00000198563	DDX39B	100	88.936	ENSTSYG00000029741	-	91	88.095	Carlito_syrichta
ENSG00000198563	DDX39B	100	100.000	ENSTSYG00000010226	-	100	100.000	Carlito_syrichta
ENSG00000198563	DDX39B	100	100.000	ENSCAPG00000010066	DDX39B	100	99.766	Cavia_aperea
ENSG00000198563	DDX39B	100	100.000	ENSCPOG00000002335	DDX39B	100	99.766	Cavia_porcellus
ENSG00000198563	DDX39B	100	100.000	ENSCCAG00000027897	DDX39B	100	100.000	Cebus_capucinus
ENSG00000198563	DDX39B	100	96.800	ENSCATG00000043709	DDX39B	100	93.176	Cercocebus_atys
ENSG00000198563	DDX39B	100	100.000	ENSCLAG00000014555	DDX39B	100	99.766	Chinchilla_lanigera
ENSG00000198563	DDX39B	100	100.000	ENSCSAG00000008517	DDX39B	100	99.765	Chlorocebus_sabaeus
ENSG00000198563	DDX39B	95	100.000	ENSCPBG00000014671	-	100	100.000	Chrysemys_picta_bellii
ENSG00000198563	DDX39B	100	100.000	ENSCANG00000041217	DDX39B	100	100.000	Colobus_angolensis_palliatus
ENSG00000198563	DDX39B	95	91.525	ENSCGRG00001021916	-	89	84.358	Cricetulus_griseus_chok1gshd
ENSG00000198563	DDX39B	100	99.160	ENSCGRG00001017315	-	95	99.029	Cricetulus_griseus_chok1gshd
ENSG00000198563	DDX39B	100	99.160	ENSCGRG00000012479	-	76	99.184	Cricetulus_griseus_crigri
ENSG00000198563	DDX39B	100	97.600	ENSCGRG00000000078	-	90	98.537	Cricetulus_griseus_crigri
ENSG00000198563	DDX39B	100	92.184	ENSDARG00000036069	ddx39b	100	92.414	Danio_rerio
ENSG00000198563	DDX39B	100	100.000	ENSDNOG00000010215	DDX39B	100	100.000	Dasypus_novemcinctus
ENSG00000198563	DDX39B	100	99.654	ENSDORG00000004985	Ddx39b	100	99.733	Dipodomys_ordii
ENSG00000198563	DDX39B	100	98.701	ENSETEG00000009649	DDX39B	87	86.898	Echinops_telfairi
ENSG00000198563	DDX39B	100	100.000	ENSEASG00005017156	DDX39B	100	100.000	Equus_asinus_asinus
ENSG00000198563	DDX39B	100	100.000	ENSECAG00000007750	DDX39B	100	100.000	Equus_caballus
ENSG00000198563	DDX39B	95	97.753	ENSELUG00000017904	ddx39b	100	92.343	Esox_lucius
ENSG00000198563	DDX39B	100	99.766	ENSFCAG00000004497	DDX39B	100	99.766	Felis_catus
ENSG00000198563	DDX39B	100	100.000	ENSFDAG00000011074	DDX39B	100	99.766	Fukomys_damarensis
ENSG00000198563	DDX39B	95	100.000	ENSGAGG00000001300	-	80	99.684	Gopherus_agassizii
ENSG00000198563	DDX39B	100	100.000	ENSGGOG00000005989	DDX39B	100	100.000	Gorilla_gorilla
ENSG00000198563	DDX39B	100	86.822	ENSHBUG00000022054	-	77	88.038	Haplochromis_burtoni
ENSG00000198563	DDX39B	100	99.299	ENSHGLG00000019248	DDX39B	100	99.299	Heterocephalus_glaber_female
ENSG00000198563	DDX39B	100	99.299	ENSHGLG00100011850	DDX39B	100	99.299	Heterocephalus_glaber_male
ENSG00000198563	DDX39B	95	96.629	ENSIPUG00000015733	DDX39B	94	91.743	Ictalurus_punctatus
ENSG00000198563	DDX39B	100	100.000	ENSSTOG00000012838	DDX39B	100	99.533	Ictidomys_tridecemlineatus
ENSG00000198563	DDX39B	100	99.299	ENSJJAG00000005660	-	100	99.299	Jaculus_jaculus
ENSG00000198563	DDX39B	100	76.050	ENSLBEG00000017177	-	85	75.102	Labrus_bergylta
ENSG00000198563	DDX39B	96	83.799	ENSLBEG00000012254	ddx39b	99	78.220	Labrus_bergylta
ENSG00000198563	DDX39B	95	100.000	ENSLACG00000002110	DDX39B	100	89.862	Latimeria_chalumnae
ENSG00000198563	DDX39B	100	100.000	ENSLAFG00000014202	DDX39B	100	99.766	Loxodonta_africana
ENSG00000198563	DDX39B	100	100.000	ENSMFAG00000034233	DDX39B	100	100.000	Macaca_fascicularis
ENSG00000198563	DDX39B	100	100.000	ENSMMUG00000008839	DDX39B	100	100.000	Macaca_mulatta
ENSG00000198563	DDX39B	100	100.000	ENSMNEG00000041059	DDX39B	100	100.000	Macaca_nemestrina
ENSG00000198563	DDX39B	100	100.000	ENSMLEG00000043791	DDX39B	100	100.000	Mandrillus_leucophaeus
ENSG00000198563	DDX39B	95	95.506	ENSMZEG00005017654	ddx39b	99	90.783	Maylandia_zebra
ENSG00000198563	DDX39B	100	99.308	ENSMAUG00000008059	Ddx39b	100	99.299	Mesocricetus_auratus
ENSG00000198563	DDX39B	100	100.000	ENSMICG00000017349	DDX39B	100	100.000	Microcebus_murinus
ENSG00000198563	DDX39B	100	99.533	ENSMOCG00000011169	Ddx39b	100	99.533	Microtus_ochrogaster
ENSG00000198563	DDX39B	100	100.000	ENSMODG00000015791	DDX39B	100	95.294	Monodelphis_domestica
ENSG00000198563	DDX39B	100	98.400	MGP_CAROLIEiJ_G0021519	-	97	97.765	Mus_caroli
ENSG00000198563	DDX39B	100	99.533	ENSMUSG00000019432	Ddx39b	100	100.000	Mus_musculus
ENSG00000198563	DDX39B	100	99.533	MGP_PahariEiJ_G0020513	Ddx39b	100	100.000	Mus_pahari
ENSG00000198563	DDX39B	100	99.533	MGP_SPRETEiJ_G0022424	Ddx39b	100	99.533	Mus_spretus
ENSG00000198563	DDX39B	100	99.766	ENSMPUG00000011407	DDX39B	100	99.766	Mustela_putorius_furo
ENSG00000198563	DDX39B	95	100.000	ENSMLUG00000001681	DDX39B	100	100.000	Myotis_lucifugus
ENSG00000198563	DDX39B	100	100.000	ENSNGAG00000022948	Ddx39b	100	100.000	Nannospalax_galili
ENSG00000198563	DDX39B	95	100.000	ENSNLEG00000006094	DDX39B	100	75.467	Nomascus_leucogenys
ENSG00000198563	DDX39B	100	98.400	ENSMEUG00000008264	DDX39B	86	100.000	Notamacropus_eugenii
ENSG00000198563	DDX39B	100	99.766	ENSOPRG00000011923	DDX39B	100	99.766	Ochotona_princeps
ENSG00000198563	DDX39B	100	99.567	ENSODEG00000018083	DDX39B	100	99.533	Octodon_degus
ENSG00000198563	DDX39B	100	91.898	ENSONIG00000004740	ddx39b	100	91.898	Oreochromis_niloticus
ENSG00000198563	DDX39B	100	100.000	ENSOANG00000008361	DDX39B	95	99.156	Ornithorhynchus_anatinus
ENSG00000198563	DDX39B	100	96.163	ENSOCUG00000024126	DDX39B	100	96.163	Oryctolagus_cuniculus
ENSG00000198563	DDX39B	95	100.000	ENSOGAG00000009067	-	100	98.457	Otolemur_garnettii
ENSG00000198563	DDX39B	100	98.621	ENSOGAG00000028850	-	100	98.601	Otolemur_garnettii
ENSG00000198563	DDX39B	100	100.000	ENSOARG00000008787	DDX39B	98	99.766	Ovis_aries
ENSG00000198563	DDX39B	100	100.000	ENSPPAG00000043072	DDX39B	100	100.000	Pan_paniscus
ENSG00000198563	DDX39B	100	99.766	ENSPPRG00000001913	DDX39B	100	99.766	Panthera_pardus
ENSG00000198563	DDX39B	100	98.832	ENSPTIG00000017669	DDX39B	100	98.832	Panthera_tigris_altaica
ENSG00000198563	DDX39B	100	100.000	ENSPTRG00000032509	DDX39B	100	100.000	Pan_troglodytes
ENSG00000198563	DDX39B	100	100.000	ENSPANG00000018609	DDX39B	100	100.000	Papio_anubis
ENSG00000198563	DDX39B	95	96.629	ENSPKIG00000011324	ddx39b	100	91.304	Paramormyrops_kingsleyae
ENSG00000198563	DDX39B	100	99.299	ENSPEMG00000016905	Ddx39b	100	99.299	Peromyscus_maniculatus_bairdii
ENSG00000198563	DDX39B	100	100.000	ENSPCIG00000017572	DDX39B	100	100.000	Phascolarctos_cinereus
ENSG00000198563	DDX39B	100	100.000	ENSPPYG00000016433	DDX39B	100	100.000	Pongo_abelii
ENSG00000198563	DDX39B	95	99.438	ENSPCAG00000003484	DDX39B	100	99.648	Procavia_capensis
ENSG00000198563	DDX39B	100	100.000	ENSPCOG00000018656	DDX39B	100	100.000	Propithecus_coquereli
ENSG00000198563	DDX39B	100	99.533	ENSPVAG00000004653	DDX39B	100	99.533	Pteropus_vampyrus
ENSG00000198563	DDX39B	94	95.429	ENSPNYG00000010382	ddx39b	98	82.904	Pundamilia_nyererei
ENSG00000198563	DDX39B	100	92.202	ENSPNAG00000026926	ddx39b	100	92.202	Pygocentrus_nattereri
ENSG00000198563	DDX39B	100	99.533	ENSRNOG00000000841	Ddx39b	100	99.533	Rattus_norvegicus
ENSG00000198563	DDX39B	100	100.000	ENSRBIG00000031309	DDX39B	100	89.720	Rhinopithecus_bieti
ENSG00000198563	DDX39B	100	100.000	ENSRROG00000039517	DDX39B	100	100.000	Rhinopithecus_roxellana
ENSG00000198563	DDX39B	100	100.000	ENSSBOG00000035513	-	100	89.720	Saimiri_boliviensis_boliviensis
ENSG00000198563	DDX39B	100	98.400	ENSSBOG00000030486	-	97	97.945	Saimiri_boliviensis_boliviensis
ENSG00000198563	DDX39B	100	100.000	ENSSHAG00000003209	DDX39B	100	100.000	Sarcophilus_harrisii
ENSG00000198563	DDX39B	95	96.629	ENSSFOG00015016107	ddx39b	100	91.762	Scleropages_formosus
ENSG00000198563	DDX39B	100	93.287	ENSSDUG00000011557	ddx39b	100	93.519	Seriola_dumerili
ENSG00000198563	DDX39B	100	93.056	ENSSLDG00000015763	ddx39b	100	93.287	Seriola_lalandi_dorsalis
ENSG00000198563	DDX39B	100	99.160	ENSSARG00000005245	DDX39B	100	87.701	Sorex_araneus
ENSG00000198563	DDX39B	100	97.897	ENSSPUG00000012805	DDX39B	100	97.897	Sphenodon_punctatus
ENSG00000198563	DDX39B	100	100.000	ENSSSCG00000001400	DDX39B	100	100.000	Sus_scrofa
ENSG00000198563	DDX39B	90	100.000	ENSTBEG00000003721	DDX39B	100	76.869	Tupaia_belangeri
ENSG00000198563	DDX39B	100	100.000	ENSTTRG00000014074	DDX39B	100	91.455	Tursiops_truncatus
ENSG00000198563	DDX39B	100	99.200	ENSUAMG00000027335	DDX39B	100	86.977	Ursus_americanus
ENSG00000198563	DDX39B	100	90.888	ENSUMAG00000015124	DDX39B	100	90.888	Ursus_maritimus
ENSG00000198563	DDX39B	90	100.000	ENSVPAG00000009167	-	74	100.000	Vicugna_pacos
ENSG00000198563	DDX39B	100	99.533	ENSVVUG00000019518	DDX39B	99	99.533	Vulpes_vulpes
ENSG00000198563	DDX39B	95	97.753	ENSXETG00000002498	ddx39b	99	83.953	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000245	spliceosomal complex assembly	18593880.	IDA	Process
GO:0000346	transcription export complex	15833825.15998806.	IDA	Component
GO:0000398	mRNA splicing, via spliceosome	15047853.	IGI	Process
GO:0001889	liver development	-	IEA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004004	ATP-dependent RNA helicase activity	17562711.18593880.	IDA	Function
GO:0005515	protein binding	11979277.14667819.15047853.15870275.19836239.21859714.23299939.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21859714.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	18593880.	IDA	Component
GO:0005687	U4 snRNP	18593880.	IDA	Component
GO:0005688	U6 snRNP	18593880.	IDA	Component
GO:0005737	cytoplasm	21859714.	IDA	Component
GO:0006405	RNA export from nucleus	-	TAS	Process
GO:0006406	mRNA export from nucleus	17190602.	IDA	Process
GO:0006406	mRNA export from nucleus	15047853.	IGI	Process
GO:0008186	RNA-dependent ATPase activity	17562711.	IDA	Function
GO:0008380	RNA splicing	18593880.	IDA	Process
GO:0010501	RNA secondary structure unwinding	18593880.	IDA	Process
GO:0016363	nuclear matrix	-	IEA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0016887	ATPase activity	20844015.	EXP	Function
GO:0017070	U6 snRNA binding	18593880.	IDA	Function
GO:0030621	U4 snRNA binding	18593880.	IDA	Function
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0032786	positive regulation of DNA-templated transcription, elongation	22144908.	IMP	Process
GO:0042802	identical protein binding	14667819.	IPI	Function
GO:0043008	ATP-dependent protein binding	18593880.	IDA	Function
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0045727	positive regulation of translation	-	IEA	Process
GO:0046784	viral mRNA export from host cell nucleus	18974867.	IDA	Process
GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	-	IEA	Process
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	-	IEA	Process
GO:2000002	negative regulation of DNA damage checkpoint	22144908.	IMP	Process
GO:2000573	positive regulation of DNA biosynthetic process	-	IEA	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.