EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25987486Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue.Exp Mol Pathol2015 AugJakobsen AKdoi: 10.1016/j.yexmp.2015.05.006
26959889Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer.Oncotarget2016 Mar 22Shamanna RAdoi: 10.18632/oncotarget.7906.
21542140Overexpression of Lewis(y) antigen protects ovarian cancer RMG-1 cells from carboplatin-induced apoptosis by the upregulation of Topo-I and Topo-II β.Anat Rec (Hoboken)2011 JunWang Cdoi: 10.1002/ar.21398
16799632Cellular stress triggers the human topoisomerase I damage response independently of DNA damage in a p53 controlled manner.Oncogene2007 Jan 4Rockstroh A-
12237772DNA topoisomerase I and II expression in drug resistant germ cell tumours.Br J Cancer2002 Sep 9Berney DM-
25522766Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan.Mol Cancer Ther2015 FebMeisenberg Cdoi: 10.1158/1535-7163.MCT-14-0762
24399039Topoisomerase I as a target of erlotinib and gefitinib: efficacy of combined treatments with camptothecin.Int J Oncol2014 MarPeleg Rdoi: 10.3892/ijo.2014.2244
23836376Three missense mutations of DNA topoisomerase I in highly camptothecin-resistant colon cancer cell sublines.Oncol Rep2013 SepArakawa Ydoi: 10.3892/or.2013.2594
23577133Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort.PLoS One2013Smith DHdoi: 10.1371/journal.pone.0060613
18089815Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death.Cancer Res2007 Dec 15Ganguly A-
27029323Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.J Exp Clin Cancer Res2016 Mar 31Jensen NFdoi: 10.1186/s13046-016-0335-x.
19083133Topoisomerase I and IIalpha protein expression in primary colorectal cancer and recurrences following 5-fluorouracil-based adjuvant chemotherapy.Cancer Chemother Pharmacol2009 JulTsavaris Ndoi: 10.1007/s00280-008-0886-4
27050524Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks.Cell Rep2016 Apr 12Ribeyre Cdoi: 10.1016/j.celrep.2016.03.027
24960044Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I.PLoS One2014 Jun 24Roy Adoi: 10.1371/journal.pone.0099628
11749700CPT-11 may provide therapeutic efficacy for esophageal squamous cell cancer and the effects correlate with the level of DNA topoisomerase I protein.Jpn J Cancer Res2001 DecNakajima Y-
25855483Topoisomerase-1 gene copy aberrations are frequent in patients with breast cancer.Int J Cancer2015 Oct 15K??mler Idoi: 10.1002/ijc.29556
25615400TOP1 gene copy numbers are increased in cancers of the bile duct and pancreas.Scand J Gastroenterol2015 AprGrunnet Mdoi: 10.3109/00365521.2014.980318
24327519Combined MET inhibition and topoisomerase I inhibition block cell growth of small cell lung cancer.Mol Cancer Ther2014 MarRolle CEdoi: 10.1158/1535-7163.MCT-13-0109
11844605Point mutations in the topoisomerase I gene in patients with non-small cell lung cancer treated with irinotecan.Lung Cancer2002 MarTsurutani J-
29261002Expression of Topoisomerase 1 and carboxylesterase 2 correlates with irinotecan treatment response in metastatic colorectal cancer.Cancer Biol Ther2018 Mar 4Shaojun Cdoi: 10.1080/15384047.2017.1414754
30132517DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride.Int J Oncol2018 NovLiu LMdoi: 10.3892/ijo.2018.4531

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr2041118204Missense_MutationnovelN620Y0.15
ACCchr2041084500Frame_Shift_InsnovelV185Sfs*30.33
BLCAchr2041112785Missense_MutationNAE438K0.11
BLCAchr2041092531Missense_MutationnovelP225L0.23
BLCAchr2041118276Missense_MutationnovelM644L0.4
BLCAchr2041076236Nonsense_MutationNAS74*0.33
BLCAchr2041080094Missense_MutationNAQ115H0.19
BLCAchr20410290475'UTRnovel0.47
BLCAchr2041101346Missense_MutationnovelR434Q0.09
BRCAchr20411233903'UTRnovel0.18
BRCAchr20411236093'UTRnovel0.38
BRCAchr2041122083Missense_MutationNAR708Q0.12
BRCAchr2041123240SilentNAT747T0.37
BRCAchr2041061397Missense_MutationnovelS21C0.2
BRCAchr2041076236Nonsense_MutationNAS74*0.16
BRCAchr2041115432Missense_MutationNAR567T0.2
CESCchr2041081211Missense_MutationnovelE160K0.31
CESCchr2041115436SilentnovelL568L0.18
CESCchr2041080170Missense_MutationnovelD141Y0.38
CESCchr2041122021Missense_MutationnovelK687N0.41
CESCchr20411242223'UTRnovel0.17
COADchr2041123245Missense_Mutationrs56111014R749Q0.29
COADchr2041076226Missense_MutationNAD71Y0.35
COADchr2041076281Missense_Mutationrs778237366R89Q0.15
COADchr2041080167Nonsense_MutationnovelR140*0.45
COADchr2041101259Missense_MutationnovelR405Q0.09
COADchr2041080082Splice_Regionnovel0.37
COADchr2041084502Missense_MutationnovelK183T0.17
COADchr2041100075Frame_Shift_DelNAK333Nfs*30.34
COADchr2041118169Missense_MutationnovelP608L0.07
COADchr2041112823Frame_Shift_InsnovelC453Mfs*400.27
COADchr2041061426SilentnovelR31R0.41
COADchr2041077585SilentNAR95R0.14
COADchr2041101317SilentnovelI424I0.22
COADchr2041092541SilentNAA228A0.16
COADchr2041118257Frame_Shift_DelNAT639Lfs*60.45
ESCAchr2041092521Missense_MutationnovelH222Y0.29
ESCAchr2041116294Missense_MutationnovelK575T0.3
ESCAchr20411242253'UTRnovel0.21
ESCAchr2041081238In_Frame_Delnovel0.26
ESCAchr2041122007Frame_Shift_InsnovelQ692Sfs*290.29
GBMchr2041076206In_Frame_DelNAE65del0.4
GBMchr2041100151SilentnovelP357P0.12
GBMchr2041112904SilentnovelV477V0.05
GBMchr2041114067Missense_MutationnovelE517V0.08
GBMchr2041084492Missense_MutationnovelD180Y0.28
GBMchr2041114143SilentnovelP542P0.07
GBMchr2041122048Missense_MutationnovelE696D0.15
GBMchr2041114082Missense_MutationnovelE522A0.1
GBMchr2041097262Missense_MutationnovelT258M0.22
GBMchr2041121772Missense_MutationnovelK676R0.12
GBMchr2041114017SilentnovelD500D0.05
HNSCchr2041077611Silentrs369651304K103K0.52
HNSCchr2041101317SilentnovelI424I0.26
HNSCchr20411233653'UTRnovel0.25
HNSCchr2041122109Nonsense_MutationnovelG717Vfs*20.05
HNSCchr2041116329In_Frame_DelnovelK587_T597del0.1
HNSCchr2041101296SilentnovelT417T0.18
HNSCchr20411233483'UTRnovel0.25
HNSCchr2041115413Nonsense_MutationnovelE561*0.14
HNSCchr2041114093Missense_MutationnovelE526Q0.06
KIRCchr2041116332Missense_MutationNAV588I0.31
KIRCchr2041112881Missense_MutationNAM470V0.36
LAMLchr2041097320Missense_MutationnovelN277K0.12
LIHCchr20410289685'UTRnovel0.21
LIHCchr2041081195SilentnovelT154T0.17
LIHCchr2041122043Missense_MutationnovelE695K0.24
LUADchr2041100136Missense_MutationnovelN352K0.14
LUADchr2041112820Silentrs745948657R449R0.16
LUADchr2041118208Missense_MutationNAR621H0.18
LUADchr2041100209Missense_MutationNAI377V0.24
LUADchr2041114057SilentnovelL514L0.23
LUADchr2041115402Missense_MutationnovelN557S0.13
LUADchr2041092485Missense_MutationNAR210S0.2
LUADchr2041098263Missense_MutationnovelD301H0.28
LUSCchr2041122034Missense_MutationnovelQ692E0.15
LUSCchr2041076173Missense_MutationNAE53G0.22
LUSCchr2041112857SilentnovelR462R0.22
LUSCchr2041076170Splice_SitenovelX52_splice0.38
LUSCchr2041076281Missense_Mutationrs778237366R89Q0.25
LUSCchr2041076198Missense_MutationNAH61Q0.1
LUSCchr2041118267Missense_MutationnovelE641Q0.23
LUSCchr2041115429Missense_MutationnovelD566G0.25
MESOchr2041084494Missense_MutationnovelD180E0.07
OVchr2041101252Missense_MutationnovelE403Q0.1
OVchr2041112890Silentrs750868062R473R0.13
OVchr2041116319SilentNAG583G0.13
OVchr2041121761SilentnovelA672A0.03
OVchr2041029447Missense_Mutationrs761127035R17Q0.43
OVchr2041077588Missense_MutationNAA96S0.21
PRADchr2041097296SilentnovelT269T0.33
READchr2041084481Missense_MutationnovelP176H0.06
READchr2041084473Frame_Shift_InsnovelP176Tfs*40.23
READchr2041081186Missense_MutationnovelK151N0.1
READchr2041116278Missense_MutationNAT570P0.35
READchr2041084485Missense_MutationNAK177N0.3
READchr2041112925Missense_MutationnovelK484N0.44
READchr2041081216Missense_MutationNAK161N0.42
READchr2041097233Missense_MutationnovelK248N0.28
READchr2041098385Intronnovel0.62
READchr2041114039Missense_MutationNAR508C0.18
SKCMchr2041029434Missense_MutationnovelE13K0.25
SKCMchr2041101234Missense_MutationnovelP397S0.19
SKCMchr2041114039Missense_MutationNAR508C0.32
SKCMchr2041101222Missense_MutationNAP393S0.4
SKCMchr2041112859SilentNAR462R0.13
SKCMchr2041123214Missense_MutationnovelP739S0.68
SKCMchr2041123215Missense_MutationnovelP739L0.68
SKCMchr2041080132Missense_MutationNAP128L0.17
SKCMchr2041101258SilentNAR405R0.43
SKCMchr2041122125Missense_MutationnovelN722S0.05
SKCMchr2041122083Missense_MutationNAR708L0.47
SKCMchr2041084562Nonsense_MutationNAW203*0.64
SKCMchr2041114110Silentrs561394494G531G0.14
SKCMchr2041101314SilentnovelS423S0.27
SKCMchr2041092572Frame_Shift_DelnovelK239Vfs*40.12
SKCMchr2041122147SilentNAT729T0.51
SKCMchr2041122005Splice_SitenovelX682_splice0.45
SKCMchr2041122006Splice_RegionnovelK682K0.46
SKCMchr2041112923Nonsense_MutationNAK484*0.52
SKCMchr2041098400Intronnovel0.45
SKCMchr2041100152Missense_MutationnovelP358S0.35
STADchr2041114019Missense_MutationNAT501I0.32
STADchr2041084538Missense_MutationnovelP195L0.36
STADchr2041122079Missense_MutationNAD707H0.04
STADchr2041097315Frame_Shift_DelnovelN277Ifs*100.43
STADchr2041092540Frame_Shift_DelnovelP229Hfs*190.16
STADchr2041098339Splice_SiteNAX325_splice0.34
STADchr2041100164Missense_MutationNAR362C0.33
STADchr2041081188Missense_MutationNAI152N0.32
STADchr2041100206Nonsense_MutationNAR376*0.22
STADchr2041061465Missense_Mutationrs751834546R44W0.27
STADchr2041112855Missense_MutationnovelY461C0.24
TGCTchr2041123238Frame_Shift_DelnovelT747Cfs*50.31
THYMchr2041061435SilentnovelR34R0.08
UCECchr2041061411Missense_MutationNAD26Y0.24
UCECchr2041084485Missense_MutationNAK177N0.39
UCECchr2041077585Nonsense_MutationnovelR95*0.35
UCECchr2041100218Missense_Mutationrs756669367E380K0.26
UCECchr2041098388Intronnovel0.42
UCECchr20411234103'UTRnovel0.36
UCECchr2041092565Missense_MutationNAE236D0.47
UCECchr2041112841Missense_MutationNAK456N0.43
UCECchr20411242913'UTRrs7648403770.5
UCECchr2041101187Intronrs1458265820.42
UCECchr2041081221Missense_MutationNAR163I0.18
UCECchr2041115441Splice_SiteNAX569_splice0.32
UCECchr2041114154Missense_MutationNAR546Q0.29
UCECchr2041121702Missense_MutationnovelA653T0.14
UCECchr2041098400Intronnovel0.57
UCECchr20411237833'UTRnovel0.32
UCECchr2041077586Missense_Mutationrs754130011R95Q0.15
UCECchr2041116380Nonsense_MutationNAE604*0.11
UCECchr20411235763'UTRnovel0.35
UCECchr20411239443'UTRnovel0.34
UCECchr2041122082Nonsense_MutationNAR708*0.55
UCECchr2041100198Missense_MutationnovelL373P0.34
UCECchr2041116393Splice_SiteNAX608_splice0.42
UCECchr20411242613'UTRnovel0.3
UCECchr20411242923'UTRrs1389259050.47
UCECchr2041098497Intronnovel0.33
UCECchr2041118281Missense_MutationnovelM645I0.19
UCECchr2041076280Nonsense_MutationnovelR89*0.36
UCECchr2041080168Missense_Mutationrs183058581R140Q0.5
UCECchr2041097316Missense_MutationnovelK276T0.53
UCECchr20411241633'UTRnovel0.4
UCECchr2041114154Missense_MutationNAR546Q0.51
UCECchr2041061461Missense_MutationNAK42N0.27
UCECchr2041121748Missense_MutationNAA668D0.13
UCECchr2041077632SilentnovelF110F0.27
UCECchr2041097323Missense_MutationNAF278L0.52
UCECchr2041101190Intronrs7597989480.34
UCECchr2041061423Missense_MutationnovelD30Y0.13
UCECchr2041081232Missense_MutationnovelE167K0.18
UCECchr2041098418Intronnovel0.14
UCECchr2041100207Missense_MutationNAR376Q0.2
UCECchr20411236523'UTRrs5434401170.16
UCECchr20411239523'UTRnovel0.27
UCECchr2041084474Frame_Shift_DelnovelK175Nfs*460.37
UCECchr2041118170Splice_RegionNAP608P0.47
UCECchr2041101322Missense_MutationnovelY426C0.39
UCECchr20411239863'UTRnovel0.34
UCECchr20411242923'UTRnovel0.48
UCECchr2041118265Missense_MutationnovelF640S0.1
UCECchr2041080173Missense_MutationnovelE142K0.63
UCECchr2041076210Missense_MutationnovelE65D0.3
UCECchr2041076230Missense_MutationnovelG72E0.4
UCECchr2041092537Missense_MutationnovelF227C0.07
UCECchr2041123262Missense_MutationnovelA755T0.43
UCECchr20411241063'UTRnovel0.39
UCECchr2041097323Missense_MutationNAF278L0.27
UCECchr2041098286Nonsense_MutationnovelY308*0.06
UCECchr20411235193'UTRnovel0.33
UCECchr20411242623'UTRnovel0.3
UCECchr2041114099Missense_MutationNAD528Y0.47
UCECchr2041116380Nonsense_MutationNAE604*0.4
UCECchr2041122109Missense_MutationnovelG717R0.56
UCECchr20411235153'UTRnovel0.41
UCECchr2041101258Missense_MutationnovelR405W0.31
UCECchr2041077632Missense_MutationnovelF110L0.26
UCECchr20411237833'UTRnovel0.47
UCECchr20411239523'UTRnovel0.11

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
COADAMP0.70731.2657e-35
LAMLDEL0.02090.14746
LUADDEL0.11820.18308
READAMP0.87277.719e-21

Survival Analysis
CancerP-value Q-value
THYM0.014

Kaplan-Meier Survival Analysis

STAD0.029

Kaplan-Meier Survival Analysis

SARC0.0023

Kaplan-Meier Survival Analysis

UCS0.024

Kaplan-Meier Survival Analysis

HNSC0.0012

Kaplan-Meier Survival Analysis

SKCM0.0016

Kaplan-Meier Survival Analysis

ESCA0.0011

Kaplan-Meier Survival Analysis

KIRP0.018

Kaplan-Meier Survival Analysis

PAAD0.0015

Kaplan-Meier Survival Analysis

PCPG0.024

Kaplan-Meier Survival Analysis

UCEC0.027

Kaplan-Meier Survival Analysis

LIHC0.0056

Kaplan-Meier Survival Analysis

LGG0.00075

Kaplan-Meier Survival Analysis

UVM0.0078

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000198900 (Gene tree)
Gene ID
7150
Gene Symbol
TOP1
Alias
N
Full Name
DNA topoisomerase I
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
95,670 bases
Position
chr20:41,028,818-41,124,487
Accession
11986
RBP type
non-canonical RBP
Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
9756848The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.J Biol Chem1998 Oct 9Straub T-
9115577A frame shift mutation in a hot spot region of the nuclear autoantigen La (SS-B).J Autoimmun1996 DecBachmann M-
10574790Crystal structure of colicin E3 immunity protein: an inhibitor of a ribosome-inactivating RNase.Structure1999 Nov 15Li C-
30808650FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress.Life Sci Alliance2019 Feb 26Martinez-Macias MIdoi: 10.26508/lsa.201800222
14585813Expression of nucleolar-related proteins in porcine preimplantation embryos produced in vivo and in vitro.Biol Reprod2004 AprBjerregaard B-
22207204The interface of transcription and DNA replication in the mitochondria.Biochim Biophys Acta2012 Sep-OctKasiviswanathan Rdoi: 10.1016/j.bbagrm.2011.12.005
9588897Nucleolar function and size in cancer cells.Am J Pathol1998 MayDerenzini M-
9211974Relative distribution of rDNA and proteins of the RNA polymerase I transcription machinery at chromosomal NORs.Chromosoma1997 JunSuja JA-
12658636Nucleolar proteins and ultrastructure in bovine in vivo developed, in vitro produced, and parthenogenetic cleavage-stage embryos.Mol Reprod Dev2003 MayLaurincik J-
11319160Immunolocalization of nucleolar proteins during bovine oocyte growth, meiotic maturation, and fertilization.Biol Reprod2001 MayFair T-
24667787Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2.Eur J Hum Genet2015 JanXia Qdoi: 10.1038/ejhg.2014.48
16427078Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells.J Mol Biol2006 Mar 17Khobta A-
6098156Enzyme studies of replication of the Escherichia coli chromosome.Adv Exp Med Biol1984Kornberg A-
6088063Replication initiated at the origin (oriC) of the E. coli chromosome reconstituted with purified enzymes.Cell1984 AugKaguni JM-
2175912Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system.Proc Natl Acad Sci U S A1990 DecMatsumoto T-
2181283Identification of a Saccharomyces cerevisiae DNA-binding protein involved in transcriptional regulation.Mol Cell Biol1990 AprWang H-
9720989The phosphoprotein pp135 is an essential constituent of the fibrillar components of nucleoli and of coiled bodies.Histochem Cell Biol1998 AugVandelaer M-
9112231Antinuclear autoantibodies: probes for defining proteolytic events associated with apoptosis.Mol Biol Rep1996Casiano CA-
8579976Immunologic aspects of scleroderma.Curr Opin Rheumatol1995 NovWhite B-
8083304Conformational information in DNA: its role in the interaction with DNA topoisomerase I and nucleosomes.J Cell Biochem1994 MayCaserta M-
11090457Nucleolar proteins and ultrastructure in preimplantation porcine embryos developed in vivo.Biol Reprod2000 DecHyttel P-
16226712Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.Biochem Biophys Res Commun2005 Dec 2Niture SK-
15745627Meiosis and embryo technology: renaissance of the nucleolus.Reprod Fertil Dev2005Maddox-Hyttel P-
15112326Nucleolar ultrastructure and protein allocation in in vitro produced porcine embryos.Mol Reprod Dev2004 JulLaurincik J-
19132895Monoclonal antibody and siRNAs for topoisomerase I suppress telomerase activity.Hybridoma (Larchmt)2009 FebTakahashi Hdoi: 10.1089/hyb.2008.0066.
18702506The binding of topoisomerase I to T antigen enhances the synthesis of RNA-DNA primers during simian virus 40 DNA replication.Biochemistry2008 Sep 9Khopde Sdoi: 10.1021/bi800825r
17587596The giant fibrillar center: a nucleolar structure enriched in upstream binding factor (UBF) that appears in transcriptionally more active sensory ganglia neurons.J Struct Biol2007 SepCasafont I-
17466364Ribosomal RNA and nucleolar proteins from the oocyte are to some degree used for embryonic nucleolar formation in cattle and pig.Theriogenology2007 Sep 1Maddox-Hyttel P-
17176556Nucleolar remodeling in nuclear transfer embryos.Adv Exp Med Biol2007Laurincik J-
21771901Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast.Proc Natl Acad Sci U S A2011 Aug 2Sperling ASdoi: 10.1073/pnas.1106834108
25851487RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability.Nat Commun2015 Apr 8Li Mdoi: 10.1038/ncomms7720.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000361337TOP1-2013738-ENSP00000354522765 (aa)-P11387
Gene Model
Click here to download ENSG00000198900's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000198900Cystatins9.19147722232086E-517903292
ENSG00000198900Cholesterol, LDL3E-1920686565
ENSG00000198900Cholesterol1E-1624097068
ENSG00000198900Cholesterol, LDL5E-1824097068
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000198900rs60295262041043978ALDL cholesterol24097068[NR] unit increase0.044EFO_0004611
ENSG00000198900rs81220942041053043CHighest math class taken30038396[0.0096-0.0202] unit increase0.0149EFO_0004875
ENSG00000198900rs60165052041049649?Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction)28560309HP_0100543|EFO_0000249|EFO_0007710
ENSG00000198900rs60295262041043978ALDL cholesterol20686565[1.08-1.74] mg/dL increase1.41EFO_0004611
ENSG00000198900rs60653112041095698TLDL cholesterol levels28334899[0.035-0.049] unit decrease (EA Beta value)0.0417EFO_0004611
ENSG00000198900rs60653112041095698TLDL cholesterol levels28334899[0.035-0.049] unit decrease (EA Beta value)0.0417EFO_0004611
ENSG00000198900rs60653112041095698TLDL cholesterol levels28334899[0.028-0.069] unit decrease0.0485EFO_0004611
ENSG00000198900rs60653112041095698TLDL cholesterol levels28334899[0.028-0.069] unit decrease0.0485EFO_0004611
ENSG00000198900rs60295262041043978TTotal cholesterol levels29507422unit decrease0.028EFO_0004574
ENSG00000198900rs60295262041043978TTotal cholesterol levels29507422unit decrease0.027EFO_0004574
ENSG00000198900rs60295262041043978TLow density lipoprotein cholesterol levels29507422unit decrease0.031EFO_0004611
ENSG00000198900rs60295262041043978TLow density lipoprotein cholesterol levels29507422unit decrease0.029EFO_0004611
ENSG00000198900rs761642342041049841?Heel bone mineral density30595370EFO_0009270
ENSG00000198900rs22237452041085229?Red blood cell count30595370EFO_0004305
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198900's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000198900TOP110097.001ENSMUSG00000070544Top110097.001Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000228nuclear chromosome9049244.IDAComponent
GO:0000932P-body12878161.IDAComponent
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding22904072.IDAFunction
GO:0001650fibrillar center-IDAComponent
GO:0003677DNA binding17355975.IDAFunction
GO:0003677DNA binding10497031.IMPFunction
GO:0003682chromatin binding9049244.IDAFunction
GO:0003690double-stranded DNA binding8631794.IMPFunction
GO:0003697single-stranded DNA binding8631794.IMPFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003917DNA topoisomerase type I activity21873635.IBAFunction
GO:0003917DNA topoisomerase type I activity14594810.IDAFunction
GO:0003917DNA topoisomerase type I activity8567649.8631793.8631794.9611241.14654701.17355975.IMPFunction
GO:0004674protein serine/threonine kinase activity9611241.IMPFunction
GO:0005515protein binding8567649.10352183.12878161.15448168.17234752.17314511.20195357.IPIFunction
GO:0005524ATP binding8631793.9611241.IMPFunction
GO:0005634nucleus16791210.HDAComponent
GO:0005634nucleus9049244.11016921.IDAComponent
GO:0005654nucleoplasm9049244.IDAComponent
GO:0005654nucleoplasm14654701.IMPComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005730nucleolus9049244.IDAComponent
GO:0005730nucleolus14654701.IMPComponent
GO:0006260DNA replication21873635.IBAProcess
GO:0006265DNA topological change21873635.IBAProcess
GO:0006265DNA topological change14594810.IDAProcess
GO:0006265DNA topological change8567649.8631793.8631794.9611241.14654701.IMPProcess
GO:0006338chromatin remodeling21873635.IBAProcess
GO:0006338chromatin remodeling22904072.IMPProcess
GO:0007059chromosome segregation21873635.IBAProcess
GO:0007623circadian rhythm22904072.IEPProcess
GO:0009330DNA topoisomerase complex (ATP-hydrolyzing)8567649.8631793.8631794.9611241.14654701.IMPComponent
GO:0012501programmed cell death17172417.NASProcess
GO:0016032viral process-IEAProcess
GO:0016310phosphorylation17481653.NASProcess
GO:0018105peptidyl-serine phosphorylation9611241.IMPProcess
GO:0019904protein domain specific binding9611241.IPIFunction
GO:0031298replication fork protection complex21873635.IBAComponent
GO:0032922circadian regulation of gene expression22904072.IMPProcess
GO:0032993protein-DNA complex10497031.IMPComponent
GO:0040016embryonic cleavage-IEAProcess
GO:0042493response to drug16127745.IEPProcess
GO:0043204perikaryon-IEAComponent
GO:0097100supercoiled DNA binding8631793.9611241.14654701.IMPFunction
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