EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17233835	Elevated expression of protein regulator of cytokinesis 1, involved in the growth of breast cancer cells.	Cancer Sci	2007 Feb	Shimo A	-
26898432	Protein regulator of cytokinesis 1 overexpression predicts biochemical recurrence in men with prostate cancer.	Biomed Pharmacother	2016 Mar	Luo HW	doi: 10.1016/j.biopha.2016.01.004
28190297	Elevated PRC1 in gastric carcinoma exerts oncogenic function and is targeted by piperlongumine in a p53-dependent manner.	J Cell Mol Med	2017 Jul	Zhang B	doi: 10.1111/jcmm.13063
30068546	PTE, a novel module to target Polycomb Repressive Complex 1 to the human cyclin D2 (CCND2) oncogene.	J Biol Chem	2018 Sep 14	Cameron SR	doi: 10.1074/jbc.RA118.005010

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr15	90974609	Missense_Mutation	novel	E442D	0.29
BLCA	chr15	90979187	Missense_Mutation	novel	E360K	0.08
BLCA	chr15	90981164	Intron	novel		0.31
BLCA	chr15	90979272	Silent	novel	L331L	0.44
BLCA	chr15	90969469	Missense_Mutation	novel	A576V	0.49
BLCA	chr15	90979270	Missense_Mutation	novel	Q332R	0.43
BLCA	chr15	90974216	Missense_Mutation	novel	E461Q	0.62
BLCA	chr15	90981060	Intron	novel		0.44
BLCA	chr15	90981437	Intron	novel		0.61
BLCA	chr15	90970503	In_Frame_Ins	novel	T492dup	0.64
BLCA	chr15	90981423	Intron	novel		0.38
BLCA	chr15	90994412	Missense_Mutation	novel	R2S	0.15
BLCA	chr15	90984116	Missense_Mutation	novel	E57K	0.09
BLCA	chr15	90974603	Missense_Mutation	NA	E444D	0.54
BRCA	chr15	90974635	Missense_Mutation	novel	E434Q	0.08
BRCA	chr15	90981564	Missense_Mutation	NA	E203K	0.29
BRCA	chr15	90966378	3'UTR	novel		0.16
BRCA	chr15	90981845	Missense_Mutation	novel	L135P	0.09
BRCA	chr15	90966996	3'UTR	novel		0.14
BRCA	chr15	90981582	Missense_Mutation	NA	E197K	0.1
CESC	chr15	90966336	3'UTR	novel		0.45
COAD	chr15	90981150	Intron	novel		0.31
COAD	chr15	90967158	Silent	novel	I612I	0.27
COAD	chr15	90970461	Silent	novel	I505I	0.07
COAD	chr15	90981652	Silent	NA	E173E	0.42
COAD	chr15	90984024	Silent	novel	P87P	0.09
COAD	chr15	90970509	Silent	rs773584087	N489N	0.48
COAD	chr15	90994505	5'Flank	novel		0.25
COAD	chr15	90981660	Missense_Mutation	rs573547983	R171C	0.2
COAD	chr15	90967067	3'UTR	novel		0.17
COAD	chr15	90974152	Missense_Mutation	rs369605877	P482L	0.08
COAD	chr15	90967065	3'UTR	novel		0.45
COAD	chr15	90974191	Missense_Mutation	rs141668295	R469Q	0.19
COAD	chr15	90984743	Missense_Mutation	NA	P32S	0.21
COAD	chr15	90979182	Silent	rs755639807	T361T	0.17
ESCA	chr15	90981951	Missense_Mutation	novel	E100Q	0.18
GBM	chr15	90980992	Silent	novel	G238G	0.07
GBM	chr15	90981762	Missense_Mutation	novel	L163V	0.15
GBM	chr15	90981070	Intron	novel		0.09
GBM	chr15	90969460	Missense_Mutation	novel	Y579S	0.08
GBM	chr15	90981853	Silent	rs769988851	C132C	0.24
GBM	chr15	90974210	Silent	novel	L463L	0.03
HNSC	chr15	90974603	Silent	novel	E444E	0.17
HNSC	chr15	90984123	Missense_Mutation	novel	M54I	0.15
HNSC	chr15	90979261	Missense_Mutation	novel	D335G	0.25
HNSC	chr15	90994442	5'UTR	rs548466582		0.26
HNSC	chr15	90967175	Missense_Mutation	novel	D607H	0.25
HNSC	chr15	90979246	Missense_Mutation	rs529515389	R340Q	0.1
KIRC	chr15	90974673	Missense_Mutation	NA	F421Y	0.26
KIRP	chr15	90974194	Missense_Mutation	NA	P468H	0.09
KIRP	chr15	90980997	Missense_Mutation	NA	E237K	0.12
LAML	chr15	90967086	3'UTR	novel		0.06
LAML	chr15	90984743	Missense_Mutation	novel	P32T	0.06
LIHC	chr15	90979229	Frame_Shift_Ins	novel	E346*	0.26
LUAD	chr15	90984135	Silent	novel	L50L	0.15
LUAD	chr15	90981660	Missense_Mutation	novel	R171S	0.23
LUAD	chr15	90969528	Silent	NA	L556L	0.07
LUAD	chr15	90981613	Missense_Mutation	novel	E186D	0.17
LUAD	chr15	90976743	Missense_Mutation	novel	T379I	0.57
LUAD	chr15	90979295	Splice_Site	novel	X324_splice	0.26
LUAD	chr15	90967146	Silent	NA	T616T	0.12
LUAD	chr15	90980280	Missense_Mutation	NA	S311N	0.45
LUSC	chr15	90980923	Silent	NA	A261A	0.26
LUSC	chr15	90969456	Silent	rs755126459	S580S	0.24
LUSC	chr15	90974154	Silent	novel	T481T	0.17
LUSC	chr15	90984814	Missense_Mutation	rs570196720	A8V	0.18
LUSC	chr15	90970428	Silent	NA	S516S	0.21
LUSC	chr15	90981030	Frame_Shift_Del	novel	*E226Kfs52**	0.19
LUSC	chr15	90981488	Intron	novel		0.3
LUSC	chr15	90984084	Missense_Mutation	NA	K67N	0.08
LUSC	chr15	90981582	Missense_Mutation	NA	E197Q	0.16
LUSC	chr15	90981787	Silent	novel	N154N	0.14
LUSC	chr15	90980889	Missense_Mutation	novel	K273Q	0.19
OV	chr15	90974137	Missense_Mutation	novel	K487M	0.07
OV	chr15	90967084	3'UTR	novel		0.49
OV	chr15	90974699	Missense_Mutation	novel	L412F	0.05
OV	chr15	90974194	Missense_Mutation	NA	P468R	0.33
OV	chr15	90969524	Missense_Mutation	rs201777744	G558C	0.41
OV	chr15	90984075	Silent	rs139398740	S70S	0.32
OV	chr15	90984778	Missense_Mutation	novel	N20S	0.46
OV	chr15	90980997	Missense_Mutation	NA	E237Q	0.43
OV	chr15	90970426	Missense_Mutation	rs201630358	R517Q	0.4
OV	chr15	90976738	Nonsense_Mutation	rs574886074	R381*	0.04
PAAD	chr15	90984077	Frame_Shift_Ins	novel	*S70Ifs17**	0.37
PAAD	chr15	90981745	Splice_Region	novel		0.45
PAAD	chr15	90969114	Missense_Mutation	novel	P586S	0.14
PAAD	chr15	90981176	Intron	novel		0.12
PRAD	chr15	90970500	Silent	novel	T492T	0.06
READ	chr15	90981650	Missense_Mutation	NA	F174C	0.27
READ	chr15	90981852	Missense_Mutation	NA	E133K	0.25
READ	chr15	90970427	Nonsense_Mutation	rs768808438	R517*	0.38
READ	chr15	90979162	Missense_Mutation	NA	F368C	0.67
SARC	chr15	90979188	Silent	novel	E359E	0.23
SKCM	chr15	90969517	Missense_Mutation	NA	Y560C	0.81
SKCM	chr15	90966944	3'UTR	novel		0.43
SKCM	chr15	90970429	Missense_Mutation	NA	S516Y	0.05
SKCM	chr15	90984047	Missense_Mutation	NA	C80R	0.47
SKCM	chr15	90967134	Silent	rs754911682	S620S	0.38
SKCM	chr15	90969501	Silent	novel	P565P	0.4
SKCM	chr15	90969502	Missense_Mutation	novel	P565L	0.4
SKCM	chr15	90980391	Splice_Site	NA	X275_splice	0.39
SKCM	chr15	90976750	Nonsense_Mutation	NA	R377*	0.5
SKCM	chr15	90976723	Silent	novel	L386L	0.37
SKCM	chr15	90974624	Silent	NA	E437E	0.28
STAD	chr15	90981559	Silent	rs745615333	D204D	0.37
STAD	chr15	90984815	Missense_Mutation	NA	A8T	0.36
STAD	chr15	90984052	Missense_Mutation	rs777202528	T78I	0.27
STAD	chr15	90994499	5'Flank	novel		0.39
STAD	chr15	90994454	5'UTR	novel		0.1
STAD	chr15	90980975	Missense_Mutation	rs778285093	R244Q	0.28
STAD	chr15	90974599	Missense_Mutation	NA	A446T	0.28
STAD	chr15	90974174	Nonsense_Mutation	NA	R475*	0.28
THCA	chr15	90974710	Nonsense_Mutation	rs549267890	R409*	0.04
THCA	chr15	90980329	Missense_Mutation	NA	E295K	0.16
UCEC	chr15	90966379	3'UTR	novel		0.41
UCEC	chr15	90967098	3'UTR	novel		0.38
UCEC	chr15	90967040	3'UTR	novel		0.28
UCEC	chr15	90966293	3'UTR	novel		0.34
UCEC	chr15	90981107	Intron	novel		0.42
UCEC	chr15	90981879	Missense_Mutation	novel	L124I	0.38
UCEC	chr15	90980988	Missense_Mutation	rs776619186	R240C	0.37
UCEC	chr15	90966283	3'UTR	novel		0.29
UCEC	chr15	90974177	Missense_Mutation	novel	R474W	0.33
UCEC	chr15	90981918	Nonsense_Mutation	NA	R111*	0.37
UCEC	chr15	90979212	Silent	novel	L351L	0.35
UCEC	chr15	90970434	Silent	NA	P514P	0.1
UCEC	chr15	90981107	Intron	novel		0.38
UCEC	chr15	90981917	Missense_Mutation	rs142124129	R111Q	0.4
UCEC	chr15	90979247	Missense_Mutation	rs777958468	R340W	0.32
UCEC	chr15	90980320	Nonsense_Mutation	NA	R298*	0.29
UCEC	chr15	90981846	Missense_Mutation	novel	L135I	0.16
UCEC	chr15	90969077	Splice_Site	novel	X597_splice	0.22
UCEC	chr15	90981660	Missense_Mutation	rs573547983	R171C	0.38
UCEC	chr15	90981782	Missense_Mutation	novel	F156S	0.35
UCEC	chr15	90984777	Silent	novel	N20N	0.39
UCEC	chr15	90966365	3'UTR	novel		0.5
UCEC	chr15	90969114	Missense_Mutation	novel	P586S	0.46
UCEC	chr15	90969573	Silent	novel	R541R	0.51
UCEC	chr15	90976708	Nonsense_Mutation	NA	Q391*	0.34
UCEC	chr15	90970486	Missense_Mutation	rs777459882	T497M	0.41
UCEC	chr15	90969467	Missense_Mutation	novel	S577G	0.23
UCEC	chr15	90970469	Missense_Mutation	rs200964554	R503W	0.23
UCEC	chr15	90976750	Nonsense_Mutation	NA	R377*	0.32
UCEC	chr15	90967049	3'UTR	novel		0.24
UCEC	chr15	90966409	3'UTR	novel		0.49
UCEC	chr15	90969480	Silent	novel	I572I	0.38
UCEC	chr15	90981942	Silent	novel	L103L	0.41
UCEC	chr15	90966342	3'UTR	novel		0.36
UCEC	chr15	90981938	Missense_Mutation	rs558894857	R104H	0.45
UCEC	chr15	90967098	3'UTR	rs763496387		0.26
UCEC	chr15	90969612	Silent	novel	A528A	0.39
UCEC	chr15	90966272	3'UTR	novel		0.52
UCEC	chr15	90966331	3'UTR	novel		0.53
UCEC	chr15	90979192	Nonsense_Mutation	novel	W358*	0.26
UCEC	chr15	90969448	Missense_Mutation	rs373811756	A583V	0.25
UCEC	chr15	90970427	Nonsense_Mutation	rs768808438	R517*	0.19
UCEC	chr15	90984731	Missense_Mutation	novel	R36W	0.46
UCEC	chr15	90981788	Missense_Mutation	novel	N154S	0.06
UCEC	chr15	90974678	Missense_Mutation	NA	K419N	0.22
UCEC	chr15	90981968	Missense_Mutation	NA	T94M	0.27

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2203	0.0058042
ESCA	AMP	0.25	0.10665
LGG	AMP	0.0234	0.19963
LIHC	DEL	0.1757	0.056724
PAAD	AMP	0.0761	0.20695
SKCM	AMP	0.2507	9.6912e-06

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0061	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.024	Kaplan-Meier Survival Analysis
SARC	0.047	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
SKCM	0.00014	Kaplan-Meier Survival Analysis
KIRP	0.00017	Kaplan-Meier Survival Analysis
PAAD	0.00012	Kaplan-Meier Survival Analysis
PCPG	0.029	Kaplan-Meier Survival Analysis
CESC	0.02	Kaplan-Meier Survival Analysis
READ	0.018	Kaplan-Meier Survival Analysis
KICH	0.0044	Kaplan-Meier Survival Analysis
UCEC	0.0026	Kaplan-Meier Survival Analysis
LIHC	0.0004	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
CHOL	0.0084	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.021	Kaplan-Meier Survival Analysis
OV	0.021	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000198901 (Gene tree)
Gene ID: 9055
Gene Symbol: PRC1
Alias: ASE1
Full Name: protein regulator of cytokinesis 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 29,592 bases
Position: chr15:90,966,038-90,995,629
Accession: 9341
RBP type: non-canonical RBP
Summary: This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29073373	Denaturing CLIP, dCLIP, Pipeline Identifies Discrete RNA Footprints on Chromatin-Associated Proteins and Reveals that CBX7 Targets 3' UTRs to Regulate mRNA Expression.	Cell Syst	2017 Oct 25	Rosenberg M	doi: 10.1016/j.cels.2017.09.014.
29220657	hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing.	Mol Cell	2017 Dec 7	Pintacuda G	doi: 10.1016/j.molcel.2017.11.013.
19791798	Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.	Biochemistry	2009 Nov 10	Bezsonova I	doi: 10.1021/bi901131u.
24986859	Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes.	Elife	2014 Jul 1	Bonasio R	doi: 10.7554/eLife.02637.
27326334	Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7.	ACS Med Chem Lett	2016 Feb 29	Ren C	doi: 10.1021/acsmedchemlett.6b00042
21402785	REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements.	Mol Cell Biol	2011 May	Ren X	doi: 10.1128/MCB.05088-11
27856324	MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27acetylation.	Exp Hematol	2017 Mar	Godfrey L	doi: 10.1016/j.exphem.2016.11.003

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000394249	PRC1-202	3034	XM_006720759	ENSP00000377793	620 (aa)	XP_006720822	O43663
ENST00000559811	PRC1-215	414	-	ENSP00000453117	110 (aa)	-	H0YLA0
ENST00000559326	PRC1-214	476	-	-	- (aa)	-	-
ENST00000555455	PRC1-206	830	-	ENSP00000451344	238 (aa)	-	G3V3N7
ENST00000417173	PRC1-203	1215	-	-	- (aa)	-	-
ENST00000559828	PRC1-216	584	-	ENSP00000453063	195 (aa)	-	H0YL53
ENST00000361188	PRC1-201	4087	XM_005254987	ENSP00000354679	606 (aa)	XP_005255044	O43663
ENST00000556129	PRC1-209	583	-	-	- (aa)	-	-
ENST00000557905	PRC1-213	571	-	ENSP00000453455	154 (aa)	-	H0YM42
ENST00000555791	PRC1-208	660	-	-	- (aa)	-	-
ENST00000556972	PRC1-210	728	-	ENSP00000456737	46 (aa)	-	H3BSJ8
ENST00000557763	PRC1-212	933	-	-	- (aa)	-	-
ENST00000560423	PRC1-217	755	-	ENSP00000453977	64 (aa)	-	H0YNE4
ENST00000556982	PRC1-211	583	-	-	- (aa)	-	-
ENST00000560605	PRC1-218	576	-	-	- (aa)	-	-
ENST00000442656	PRC1-204	2060	XM_017022717	ENSP00000409549	525 (aa)	XP_016878206	O43663
ENST00000560914	PRC1-219	673	-	-	- (aa)	-	-
ENST00000555745	PRC1-207	582	-	-	- (aa)	-	-
ENST00000553494	PRC1-205	717	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000198901's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000198901	alpha-Tocopherol	1.9950000E-005	-
ENSG00000198901	Diabetes Mellitus, Type 2	2E-10	20581827
ENSG00000198901	Breast Neoplasms	4E-8	25038754

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198901	rs12595025	15	90976901	T	Mean platelet volume	27863252	[0.038-0.059] unit increase	0.04882719	EFO_0004584
ENSG00000198901	rs2290203	15	90968837	G	Breast cancer	25038754	[1.05-1.11]	1.08	EFO_0000305
ENSG00000198901	rs8042680	15	90978107	A	Type 2 diabetes	20581827	[1.05-1.09]	1.07	EFO_0001360
ENSG00000198901	rs8042680	15	90978107	A	Type 2 diabetes	28869590	[0.039-0.075] unit increase	0.057	EFO_0001360
ENSG00000198901	rs8042680	15	90978107	A	Type 2 diabetes	28869590	[0.042-0.084] unit increase	0.0627	EFO_0001360
ENSG00000198901	rs540970650	15	90973347	?	General cognitive ability	29844566	z-score decrease	4.539	EFO_0004337
ENSG00000198901	rs12910825	15	90968030	G	Type 2 diabetes	30054458	[0.037-0.066] unit increase	0.0517	EFO_0001360
ENSG00000198901	rs2290203	15	90968837	G	Breast cancer	29059683	[1.04-1.09] (Oncoarray)	1.0638298	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198901's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000198901	PRC1	100	84.416	ENSMUSG00000038943	Prc1	100	83.871	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000022	mitotic spindle elongation	9885575.	TAS	Process
GO:0000922	spindle pole	-	IEA	Component
GO:0001578	microtubule bundle formation	-	IEA	Process
GO:0005515	protein binding	14744859.16189514.16431929.17409436.19447967.19468300.23036704.	IPI	Function
GO:0005634	nucleus	17409436.	IDA	Component
GO:0005819	spindle	17351640.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005876	spindle microtubule	9885575.	TAS	Component
GO:0008017	microtubule binding	-	IEA	Function
GO:0008284	positive regulation of cell proliferation	17409436.	IMP	Process
GO:0019894	kinesin binding	16431929.	IPI	Function
GO:0019901	protein kinase binding	17351640.	IPI	Function
GO:0030496	midbody	17409436.	IDA	Component
GO:0032465	regulation of cytokinesis	17351640.	IDA	Process
GO:0051301	cell division	-	IEA	Process
GO:0070938	contractile ring	17409436.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.