EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24046108Overexpression of L1CAM is associated with tumor progression and prognosis via ERK signaling in gastric cancer.Ann Surg Oncol2014 FebIto Tdoi: 10.1245/s10434-013-3246-5
21685041Expression of l1 cell adhesion molecule and morphologic features at the invasive front of colorectal cancer.Am J Clin Pathol2011 JulKajiwara Ydoi: 10.1309/AJCP63NRBNGCTXVF.
19639167DNA hypomethylation at the CpG island is involved in aberrant expression of the L1 cell adhesion molecule gene in colorectal cancer.Int J Oncol2009 SepKato K-
24746181L1CAM promotes enrichment of immunosuppressive T cells in human pancreatic cancer correlating with malignant progression.Mol Oncol2014 JulGrage-Griebenow Edoi: 10.1016/j.molonc.2014.03.001
18931829Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration.J Mol Med (Berl)2009 JanIssa Ydoi: 10.1007/s00109-008-0410-7
22228447Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-??B activation.Ann Oncol2012 JulBondong Sdoi: 10.1093/annonc/mdr568
21600041Circulating levels of cell adhesion molecule L1 as a prognostic marker in gastrointestinal stromal tumor patients.BMC Cancer2011 May 22Zander Hdoi: 10.1186/1471-2407-11-189.
17952127The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies.Oncogene2008 Feb 21Gast D-
19401151The soluble form of the cancer-associated L1 cell adhesion molecule is a pro-angiogenic factor.Int J Biochem Cell Biol2009 JulFriedli Adoi: 10.1016/j.biocel.2009.01.006
22888955L1 cell adhesion molecule overexpression in hepatocellular carcinoma associates with advanced tumor progression and poor patient survival.Diagn Pathol2012 Aug 13Guo Xdoi: 10.1186/1746-1596-7-96.
22472175Aberrant l1 cell adhesion molecule affects tumor behavior and chemosensitivity in anaplastic thyroid carcinoma.Clin Cancer Res2012 Jun 1Kim KSdoi: 10.1158/1078-0432.CCR-11-2757
17873897L1 is associated with micrometastatic spread and poor outcome in colorectal cancer.Mod Pathol2007 NovKaifi JT-
18386459L1 (CAM) (CD171) in ovarian serous neoplasms.Eur J Gynaecol Oncol2008Daponte A-
18972120Universal expression of cell adhesion molecule NCAM in neuroblastoma in contrast to L1: implications for different roles in tumor biology of neuroblastoma?Pediatr Surg Int2008 DecWachowiak Rdoi: 10.1007/s00383-008-2264-z.
18090124The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion.Eur J Cancer Prev2007 DecNiu JX-
20501614L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinoma.Clin Cancer Res2010 Jul 15Min JKdoi: 10.1158/1078-0432.CCR-09-3075
21195665Linking L1CAM-mediated signaling to NF-??B activation.Trends Mol Med2011 AprKiefel Hdoi: 10.1016/j.molmed.2010.11.005
21860410HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.Oncogene2012 Apr 5Zhang Hdoi: 10.1038/onc.2011.365
27833079Prognostic significance of L1 cell adhesion molecule in cancer patients: A systematic review and meta-analysis.Oncotarget2016 Dec 20Hua Tdoi: 10.18632/oncotarget.13236.
30591489L1CAM as a Negative Prognostic Factor in Endometrioid Endometrial Adenocarcinoma FIGO Stage IA-IB.Anticancer Res2019 JanKlat Jdoi: 10.21873/anticanres.13128.
17699774Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis.Cancer Res2007 Aug 15Gavert N-
22983139Influence of L1-CAM expression of breast cancer cells on adhesion to endothelial cells.J Cancer Res Clin Oncol2013 JanDippel Vdoi: 10.1007/s00432-012-1306-z
26861585L1CAM is an independent predictor of poor survival in endometrial cancer - An analysis of The Cancer Genome Atlas (TCGA).Gynecol Oncol2016 MayDellinger THdoi: 10.1016/j.ygyno.2016.02.003
17211730L1 expression as a marker for poor prognosis, tumor progression, and short survival in patients with colorectal cancer.Ann Surg Oncol2007 MayBoo YJ-
26399194Clusterin, a gene enriched in intestinal stem cells, is required for L1-mediated colon cancer metastasis.Oncotarget2015 Oct 27Shapiro Bdoi: 10.18632/oncotarget.5360.
20501702Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells.J Cell Sci2010 Jun 15Gavert Ndoi: 10.1242/jcs.069542
18676824Targeting cancer stem cells through L1CAM suppresses glioma growth.Cancer Res2008 Aug 1Bao Sdoi: 10.1158/0008-5472.CAN-08-1079.
22869145Global analysis of L1-transcriptomes identified IGFBP-2 as a target of ezrin and NF-??B signaling that promotes colon cancer progression.Oncogene2013 Jul 4Ben-Shmuel Adoi: 10.1038/onc.2012.340
19661372The AA genotype of a L1C G842A polymorphism is associated with an increased risk for ovarian cancer.Anticancer Res2009 AugHeubner M-
18847309L1-CAM in cancerous tissues.Expert Opin Biol Ther2008 NovGavert Ndoi: 10.1517/14712598.8.11.1749 .
21985405L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer.Mol Cancer2011 Oct 10Tischler Vdoi: 10.1186/1476-4598-10-127.
21094640Structural mechanism of the antigen recognition by the L1 cell adhesion molecule antibody A10-A3.FEBS Lett2011 Jan 3Wei CHdoi: 10.1016/j.febslet.2010.11.028
26464672Overexpression of L1 cell adhesion molecule correlates with aggressive tumor progression of patients with breast cancer and promotes motility of breast cancer cells.Int J Clin Exp Pathol2015 Aug 1Zhang J-
23267165Utility of mesothelin, L1CAM and Afamin as biomarkers in primary ovarian cancer.Anticancer Res2013 JanAktas B-
19787228Expression and prognostic value of L1-CAM in breast cancer.Oncol Rep2009 NovSchrder C-
24422715L1 and epithelial cell adhesion molecules associated with gastric cancer progression and prognosis in examination of specimens from 601 patients.J Exp Clin Cancer Res2013 Sep 16Wang YYdoi: 10.1186/1756-9966-32-66.
22307136L1 cell adhesion molecule promotes tumorigenicity and metastatic potential in non-small cell lung cancer.Clin Cancer Res2012 Apr 1Hai Jdoi: 10.1158/1078-0432.CCR-11-2893
27174921Clinical impact of L1CAM expression measured on the transcriptome level in ovarian cancer.Oncotarget2016 Jun 14Abdel Azim Sdoi: 10.18632/oncotarget.9291.
27233077Evaluating L1CAM expression in human endometrial cancer using qRT-PCR.Oncotarget2016 Jun 28Notaro Sdoi: 10.18632/oncotarget.9574.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchrX153867827Missense_MutationnovelA638S0.2
ACCchrX153868370SilentnovelP545P0.38
BLCAchrX1538885675'Flankrs7822168550.8
BLCAchrX153862809Missense_Mutationrs781964622D1210N0.32
BLCAchrX153865787Missense_MutationnovelE822Q0.23
BLCAchrX153864956Missense_MutationNAR971W0.36
BLCAchrX153868696Missense_MutationnovelD471Y0.57
BLCAchrX153868697Missense_MutationnovelQ470H0.57
BLCAchrX153865747Missense_Mutationrs781912495P835L0.3
BLCAchrX153870465Silentrs782492763L243L0.15
BLCAchrX153867909Splice_RegionnovelG610G0.56
BLCAchrX153870097Nonsense_MutationnovelS317*0.55
BRCAchrX153866826Missense_Mutationrs137852525V752M0.24
BRCAchrX153868399Missense_MutationNAT536P0.15
BRCAchrX153868690Missense_MutationNAR473C0.17
BRCAchrX153863989Silentrs781828655F1117F0.36
BRCAchrX153864467SilentNAG1059G0.17
BRCAchrX153868336Missense_Mutationrs782479917G557S0.23
BRCAchrX153862731Missense_MutationNAE1236K0.33
BRCAchrX153865440Missense_MutationNAH870Y0.21
BRCAchrX153869545SilentnovelL414L0.08
BRCAchrX153864399Missense_MutationNAP1082L0.26
BRCAchrX153864700SilentNAI1017I0.26
BRCAchrX153871119Missense_MutationNAV154A0.71
BRCAchrX153868896Missense_MutationNAS442R0.42
BRCAchrX153862849Silentrs782086274N1196N0.25
BRCAchrX153865437Missense_MutationnovelV871L0.11
CESCchrX153863507Missense_MutationnovelP1167L0.16
CESCchrX153863888Frame_Shift_DelnovelK1150Tfs*30.15
CESCchrX153866707SilentNAV791V0.42
CESCchrX153872214Missense_Mutationrs781908326R113H0.48
CESCchrX153872630Missense_MutationnovelI53M0.18
CESCchrX1538869795'Flanknovel0.18
CESCchrX153869522Missense_MutationnovelV422A0.41
CESCchrX1538626013'UTRnovel0.11
CESCchrX153870887SilentNAL199L0.18
CESCchrX1538869775'Flanknovel0.38
CESCchrX153868441Nonsense_MutationNAQ522*0.63
CESCchrX153868452Missense_MutationNAT518S0.12
CHOLchrX153884242Intronrs3759896850.38
COADchrX153862821Missense_MutationnovelD1206N0.49
COADchrX153864446SilentnovelQ1066Q0.17
COADchrX153865107Silentrs148187017Y951Y0.26
COADchrX153869519Splice_SiteNAX423_splice0.15
COADchrX153863907Missense_Mutationrs200798819R1145C0.22
COADchrX153865124Missense_MutationNAG946S0.06
COADchrX153868864SilentNAG452G0.32
COADchrX153868333Nonsense_MutationNAR558*0.29
COADchrX153865327Silentrs200799618S907S0.13
COADchrX153872285SilentnovelS89S0.16
COADchrX1538758765'UTRnovel0.14
COADchrX153864956Missense_MutationNAR971W0.66
COADchrX153871145SilentNAP145P0.11
COADchrX153864417Missense_Mutationrs781826722T1076M0.11
COADchrX153870123Silentrs797044787G308G0.22
COADchrX153884267Intronrs1393059900.21
COADchrX153869631Missense_MutationNAR386C0.24
COADchrX153867483SilentnovelG670G0.38
COADchrX1538758375'UTRnovel0.27
COADchrX153862795Silentrs782341083S1214S0.2
COADchrX153885401Intronnovel0.33
COADchrX153868030Missense_Mutationrs782196802V599A0.43
COADchrX153868074Silentrs201440831S584S0.74
COADchrX153872350Missense_MutationNAR68C0.35
COADchrX153865750Missense_Mutationrs201550159R834Q0.63
COADchrX153870445Missense_MutationnovelS250N0.26
COADchrX1538758905'UTRnovel0.25
COADchrX1538869995'Flanknovel0.32
DLBCchrX153870917SilentnovelQ189Q0.34
ESCAchrX153868862Missense_MutationnovelA453V0.94
ESCAchrX153885368Intronnovel0.2
ESCAchrX1538621003'UTRrs7827625990.19
ESCAchrX153868631Silentrs150805225T492T0.7
ESCAchrX153865332Missense_Mutationrs782505398A906T0.5
GBMchrX153864826Nonsense_MutationnovelL1014*0.18
GBMchrX153862847Missense_MutationNAG1197E0.67
GBMchrX153866693Missense_MutationnovelK796M0.11
GBMchrX153870852Missense_MutationnovelA211V0.21
GBMchrX153863896Silentrs201721767G1148G0.13
GBMchrX153870087Missense_MutationnovelS320R0.79
GBMchrX153865171Missense_MutationNAS930L0.75
GBMchrX153868337SilentnovelD556D0.85
GBMchrX153868333Nonsense_MutationNAR558*0.13
GBMchrX153872350Missense_MutationNAR68C0.35
GBMchrX153870137Missense_Mutationrs201311640E304K0.83
GBMchrX153875805Missense_MutationNAL11R0.72
GBMchrX153865121Missense_MutationNAV947M0.85
HNSCchrX153864923Missense_MutationNAD982N0.43
HNSCchrX153867910Missense_MutationnovelG610E0.49
HNSCchrX153868109Missense_MutationnovelD573N0.37
HNSCchrX153868110SilentnovelE572E0.35
HNSCchrX153868861SilentnovelA453A0.49
HNSCchrX153862722Missense_MutationnovelG1239R0.24
HNSCchrX153866860Frame_Shift_DelnovelW740*0.67
HNSCchrX153870451Missense_MutationnovelS248C0.26
HNSCchrX153870462SilentnovelF244F0.24
HNSCchrX153868849Missense_MutationnovelS457R0.4
HNSCchrX153864671Missense_MutationnovelA1027E0.19
HNSCchrX153868890Missense_MutationnovelA444S0.2
KIRCchrX153869595Missense_MutationNAD398N0.42
KIRCchrX153863918Missense_MutationNAC1141F0.12
LGGchrX153862766Missense_MutationnovelS1224L0.29
LGGchrX153862867SilentnovelS1190S0.35
LGGchrX153864969SilentnovelL966L0.4
LGGchrX153867388Missense_Mutationrs782568205P702L0.32
LGGchrX153868612Missense_MutationnovelA499T0.32
LGGchrX153872667Missense_MutationnovelS41Y0.31
LGGchrX153864852SilentNAI1005I0.27
LGGchrX153868380Missense_MutationnovelS542F0.4
LGGchrX153867845Missense_Mutationrs782367123R632C0.28
LGGchrX153869837Missense_MutationnovelE363D0.1
LGGchrX153868436SilentNAG523G0.29
LIHCchrX153872664Missense_MutationnovelP42L0.73
LIHCchrX153870853Missense_Mutationrs202000092A211S0.33
LIHCchrX153870398Missense_MutationnovelA266T0.13
LIHCchrX153870234SilentNAT271T0.28
LIHCchrX153864476Splice_RegionNAE1056E0.48
LIHCchrX153863486Missense_MutationnovelG1174V0.86
LIHCchrX153868006Missense_MutationNAL607S0.19
LUADchrX153871111Missense_MutationNAP157T0.21
LUADchrX153866666Missense_MutationNAG805V0.24
LUADchrX153867470Missense_MutationNAT675A0.21
LUADchrX153872607Missense_MutationnovelG61V0.09
LUADchrX153870922Missense_MutationnovelG188C0.08
LUADchrX153870923Missense_MutationNAM187I0.08
LUADchrX153868905Missense_MutationNAV439L0.39
LUADchrX153865501Splice_SiteNAX850_splice0.31
LUADchrX153869851Missense_MutationNAR359W0.38
LUADchrX153872263Missense_MutationNAI97V0.33
LUADchrX153866808Missense_MutationnovelG758W0.19
LUADchrX153862857Missense_MutationNAS1194T0.14
LUADchrX153867474SilentNAT673T0.09
LUADchrX153870926Silentrs782773215T186T0.11
LUADchrX153868651Missense_MutationNAD486N0.22
LUADchrX153865417SilentnovelT877T0.16
LUADchrX153867845Missense_MutationNAR632S0.65
LUADchrX153870092Missense_MutationnovelG319C0.25
LUADchrX153865124Missense_MutationNAG946C0.54
LUADchrX153867382Missense_MutationnovelS704F0.72
LUADchrX153868626Missense_Mutationrs782038855R494H0.77
LUADchrX153866806Silentrs2071643G758G0.17
LUADchrX153865338Missense_MutationNAG904W0.19
LUADchrX153866709Missense_Mutationrs200605257V791I0.11
LUADchrX153869879SilentnovelT349T0.11
LUADchrX153870953SilentNAL177L0.29
LUADchrX153864410Missense_MutationnovelW1078C0.05
LUADchrX153864411Missense_MutationnovelW1078L0.05
LUADchrX153867405SilentnovelG696G0.09
LUADchrX153867384SilentnovelV703V0.17
LUADchrX153863527Missense_MutationNAQ1160H0.33
LUADchrX153868683Missense_MutationnovelF475S0.07
LUADchrX153870197Missense_MutationNAP284T0.16
LUADchrX153864839Missense_MutationNAG1010R0.07
LUADchrX153867845Missense_MutationNAR632S0.16
LUADchrX153869627Missense_MutationnovelG387D0.62
LUADchrX153868411Missense_MutationNAG532C0.37
LUADchrX153868039Missense_MutationnovelE596V0.22
LUADchrX153875767Missense_MutationnovelE24Q0.36
LUADchrX153868371Missense_MutationNAP545H0.2
LUADchrX153866666Missense_MutationnovelG805D0.14
LUADchrX153864321Splice_SitenovelX1108_splice0.17
LUADchrX153864322Missense_MutationnovelG1108S0.17
LUADchrX153864407Missense_MutationNAD1079E0.65
LUADchrX153862725Missense_Mutationrs144089789A1238T0.15
LUADchrX153864963SilentNAF968F0.33
LUADchrX153866827Silentrs782035973R751R0.14
LUADchrX153872318SilentNAP78P0.63
LUADchrX153864947Missense_Mutationrs782712766E974K0.32
LUADchrX1538758965'UTRnovel0.32
LUADchrX153867373Missense_MutationnovelV707A0.35
LUADchrX1538869695'Flanknovel0.15
LUADchrX153869932Missense_MutationnovelA332S0.11
LUADchrX153871126Nonsense_MutationnovelE152*0.66
LUADchrX153870813Missense_MutationNAP224L0.48
LUSCchrX153869544Missense_MutationnovelA415P0.66
LUSCchrX153865197SilentnovelP921P0.32
LUSCchrX153870956SilentnovelI176I0.91
LUSCchrX153872255SilentNAG99G0.43
LUSCchrX153870881Silentrs782223025S201S0.7
LUSCchrX153864624Missense_MutationnovelC1043S0.63
LUSCchrX153865423SilentNAA875A0.71
LUSCchrX153865424Missense_MutationNAA875D0.71
LUSCchrX153867088Missense_MutationnovelG725E0.61
LUSCchrX153868321Missense_MutationnovelE562K0.52
LUSCchrX153870473Missense_Mutationrs201642622R241C0.16
LUSCchrX153871145SilentNAP145P0.72
LUSCchrX153863499Missense_MutationnovelD1170Y0.11
LUSCchrX153865175Missense_MutationnovelQ929K0.77
LUSCchrX153867387SilentNAP702P0.78
LUSCchrX153867873Missense_MutationnovelD622E0.12
LUSCchrX153866710Silentrs145717130A790A0.37
LUSCchrX153875795Missense_MutationnovelC14W0.46
LUSCchrX153870797SilentnovelV229V0.69
LUSCchrX153868884Missense_MutationnovelL446I0.04
LUSCchrX1538870365'Flanknovel1
LUSCchrX153870084SilentnovelA321A0.85
LUSCchrX153867365Missense_MutationnovelP710T0.38
LUSCchrX153872644Missense_MutationnovelP49S0.43
LUSCchrX1538626243'UTRnovel0.67
LUSCchrX153865085Splice_Regionnovel0.17
LUSCchrX153868432Missense_MutationnovelR525S0.57
LUSCchrX153868432Missense_MutationnovelR525S0.93
LUSCchrX153868433SilentnovelP524P0.93
OVchrX153864410Nonsense_MutationNAW1078*0.49
OVchrX153866682Missense_MutationnovelP800T0.15
OVchrX153862737Missense_MutationnovelE1234Q0.13
OVchrX153865495Silentrs373921972T851T0.29
OVchrX153865728SilentNAV841V0.49
OVchrX153872210Missense_MutationnovelC114W0.08
OVchrX153865421Missense_MutationnovelN876I0.07
OVchrX153865357SilentNAA897A0.25
OVchrX153870230Missense_MutationnovelT273P0.16
OVchrX153864459Missense_MutationNAS1062F0.79
OVchrX153865338Missense_MutationnovelG904R0.25
OVchrX153871112SilentnovelL156L0.12
OVchrX153871089Missense_MutationNAA164V0.35
OVchrX153865499Missense_MutationNAV850G0.18
PAADchrX153872599Missense_MutationnovelE64Q0.29
PAADchrX153870176Nonsense_MutationNAQ291*0.24
PRADchrX153870934Missense_MutationNAR184W0.19
PRADchrX153872355Splice_SitenovelX66_splice0.39
PRADchrX153864622Missense_MutationnovelC1043W0.44
PRADchrX153866864Missense_MutationNAR739Q0.71
PRADchrX153870138SilentNAG303G0.26
PRADchrX153869633Missense_MutationNAQ385R0.25
PRADchrX153872339SilentnovelR71R0.75
READchrX153870927Missense_Mutationrs782070899T186M0.23
READchrX153869631Missense_MutationNAR386C0.8
READchrX153864696Missense_MutationNAD1019N1
READchrX153868319Missense_MutationNAE562D0.22
READchrX153868939Missense_MutationNAK427N0.62
SARCchrX153869589Missense_MutationnovelM400V0.25
SARCchrX153868866Missense_Mutationrs137852520G452R0.18
SKCMchrX153863491SilentNAT1172T0.56
SKCMchrX153869812Missense_MutationNAP372S0.28
SKCMchrX153865308Missense_MutationnovelP914S0.31
SKCMchrX153871095Missense_MutationnovelP162L0.4
SKCMchrX153871096Missense_MutationnovelP162S0.41
SKCMchrX153872318SilentnovelP78P0.37
SKCMchrX153872319Missense_MutationnovelP78L0.36
SKCMchrX1538758975'UTRnovel0.33
SKCMchrX153872314Missense_MutationNAE80Q0.17
SKCMchrX153871124SilentNAE152E0.24
SKCMchrX153869816SilentNAG370G0.14
SKCMchrX153869520Missense_MutationnovelQ423E0.78
SKCMchrX153868092SilentNAI578I0.17
SKCMchrX153864704Missense_MutationNAG1016E0.94
SKCMchrX153864705Splice_Siters200346587X1016_splice0.94
SKCMchrX153868908Missense_MutationnovelA438T0.35
SKCMchrX153868909Missense_MutationnovelM437I0.35
SKCMchrX153864967Missense_MutationNAS967F0.13
SKCMchrX153865139Missense_MutationNAP941S0.6
SKCMchrX1538758485'UTRnovel0.69
SKCMchrX153872303SilentNAG83G0.44
SKCMchrX153868615SilentnovelL498L0.76
SKCMchrX153868616SilentnovelC497C0.76
SKCMchrX153867443Missense_MutationNAH684Y0.76
SKCMchrX153862766Missense_MutationnovelS1224L0.08
SKCMchrX153864380SilentNAI1088I0.21
SKCMchrX1538758965'UTRnovel0.18
SKCMchrX153862712Missense_MutationNAD1242G0.53
SKCMchrX153866863SilentNAR739R0.44
SKCMchrX153872265Missense_MutationNAT96I0.38
SKCMchrX153868680Missense_MutationnovelP476L0.14
SKCMchrX153875831SilentNAV2V0.31
SKCMchrX153865733Nonsense_MutationnovelQ840*0.55
SKCMchrX153864457Missense_MutationNAL1063F0.36
SKCMchrX153868370SilentNAP545P0.39
SKCMchrX153864989Missense_MutationNAE960K0.91
SKCMchrX153870196Missense_MutationNAP284L0.91
SKCMchrX153872232Missense_MutationNAR107K0.45
SKCMchrX153868407Missense_MutationnovelS533F0.88
SKCMchrX153864920Missense_MutationNAL983F0.72
SKCMchrX153870210SilentnovelP279P0.8
SKCMchrX1538626063'UTRnovel1
SKCMchrX153868324Nonsense_MutationnovelQ561*0.91
SKCMchrX153868325SilentnovelL560L0.91
STADchrX153865751Missense_Mutationrs782716607R834W0.39
STADchrX153872155Missense_MutationNAE133K0.12
STADchrX153863485SilentNAG1174G0.38
STADchrX153863546Missense_MutationNAK1154T0.23
STADchrX153865197Silentrs781813303P921P0.21
STADchrX153866841Frame_Shift_Delrs782198738Q747Rfs*1040.21
STADchrX153864417Missense_Mutationrs781826722T1076M0.65
STADchrX153868345Missense_MutationNAR554C0.6
STADchrX153864355Missense_Mutationrs782807254R1097W0.1
STADchrX153862822Silentrs782110886D1205D0.44
STADchrX153868040Missense_Mutationrs137940405E596K0.85
STADchrX153868866Missense_Mutationrs137852520G452R0.77
STADchrX153866736Missense_Mutationrs200385894V782M0.2
STADchrX153868436SilentNAG523G0.2
STADchrX153868905Missense_MutationnovelV439I0.24
STADchrX153870881Silentrs782223025S201S0.07
STADchrX153868627Missense_Mutationrs782155168R494C0.09
STADchrX153866841Frame_Shift_Delrs782198738Q747Rfs*1040.17
STADchrX153864452SilentNAS1064S0.28
STADchrX153867471SilentnovelS674S0.12
STADchrX153864923Missense_MutationNAD982N0.22
STADchrX153872165SilentNAR129R0.19
STADchrX153862762Silentrs201625971F1225F0.19
STADchrX153869630Missense_Mutationrs201882430R386H0.18
STADchrX153870473Missense_Mutationrs201642622R241C0.19
STADchrX153865135In_Frame_DelnovelL942del0.28
STADchrX153862825SilentNAS1204S0.36
STADchrX153870138SilentNAG303G0.3
STADchrX153869596SilentNAS397S0.44
UCECchrX153868367SilentNAS546S0.49
UCECchrX1538626153'UTRnovel0.39
UCECchrX1538758535'UTRnovel0.46
UCECchrX153863506SilentNAP1167P0.36
UCECchrX153864652Silentrs782495914V1033V0.36
UCECchrX1538623583'UTRnovel0.33
UCECchrX153868653Missense_Mutationrs782047153R485Q0.4
UCECchrX153867114Missense_MutationNAK716N0.39
UCECchrX153868694Silentrs570097458D471D0.09
UCECchrX153868881Missense_MutationNAL447M0.35
UCECchrX153870116Missense_Mutationrs782130795R311C0.38
UCECchrX153864905Missense_Mutationrs781979227R988W0.53
UCECchrX153868689Missense_Mutationrs782516225R473H0.37
UCECchrX153870433Missense_MutationnovelA254V0.28
UCECchrX1538620273'UTRnovel0.59
UCECchrX153867435SilentnovelT686T0.35
UCECchrX1538621173'UTRrs2001276130.42
UCECchrX1538624013'UTRnovel0.42
UCECchrX153862888Silentrs200916591N1183N0.57
UCECchrX153870123Silentrs797044787G308G0.53
UCECchrX153872285SilentnovelS89S0.42
UCECchrX153864354Missense_Mutationrs374569140R1097Q0.35
UCECchrX153867899Missense_MutationnovelP614S0.49
UCECchrX153864622Nonsense_MutationNAC1043*0.11
UCECchrX153869934Missense_MutationnovelA331V0.1
UCECchrX1538885165'Flanknovel0.26
UCECchrX153867505Missense_MutationNAY663C0.42
UCECchrX153862855Silentrs781858962S1194S0.36
UCECchrX153868439Missense_MutationNAQ522H0.28
UCECchrX153875832Missense_MutationNAV2A0.25
UCECchrX153871161Missense_MutationnovelK140M0.31
UCECchrX153862795Silentrs782341083S1214S0.17
UCECchrX153872675Silentrs781887788T38T0.19
UCECchrX1538623493'UTRnovel0.25
UCECchrX1538620423'UTRnovel0.56
UCECchrX153863908SilentnovelK1144K0.11
UCECchrX153866731SilentNAP783P0.38
UCECchrX153868420Missense_MutationNAE529K0.3
UCECchrX153869890Missense_MutationnovelP346S0.26
UCECchrX1538758455'UTRnovel0.47
UCECchrX153866747Missense_MutationNAT778M0.33
UCECchrX153865355Missense_MutationnovelF898C0.42
UCECchrX153866753Missense_MutationnovelS776Y0.09
UCECchrX153873232SilentnovelH29H0.09
UCECchrX153866791Missense_MutationnovelW763C0.09
UCECchrX153867804SilentnovelI645I0.39
UCECchrX153870144Missense_MutationnovelK301N0.35
UCECchrX1538758755'UTRrs7819941330.45
UCECchrX1538623483'UTRnovel0.25
UCECchrX153865204Missense_MutationnovelG919D0.3
UCECchrX153867109Missense_MutationnovelP718H0.37
UCECchrX153869829Nonsense_MutationnovelW366*0.23
UCECchrX153865767SilentNAA828A0.25
UCECchrX1538625293'UTRnovel0.3
UCECchrX153868705Missense_MutationnovelV468M0.39
UCECchrX153870075Silentrs782291720A324A0.23
UCECchrX153866801Missense_Mutationrs782352802R760Q0.11
UCECchrX153885434Intronrs7827007920.4
UCECchrX153862866Missense_MutationnovelS1191C0.08
UCECchrX153863887SilentnovelY1151Y0.48
UCECchrX153864393Missense_MutationNAT1084I0.28
UCECchrX153862845Missense_MutationnovelD1198Y0.56
UCECchrX1538621533'UTRnovel0.29
UCECchrX153862777Silentrs782388610N1220N0.4
UCECchrX153864921Missense_MutationNAD982E0.39
UCECchrX153870441Missense_MutationNAH251Q0.38
UCECchrX1538623223'UTRnovel0.62
UCECchrX153869527Silentrs782342513Y420Y0.3
UCECchrX153868407Missense_MutationnovelS533Y0.44
UCECchrX153870917Missense_MutationnovelQ189H0.44
UCECchrX153884266Intronnovel0.27
UCECchrX1538623783'UTRnovel0.21
UCECchrX153885425Intronnovel0.39
UCECchrX153868104Silentrs2857756G574G0.29
UCECchrX1538623553'UTRrs2002560080.27
UCECchrX1538621123'UTRnovel0.26
UCECchrX1538625413'UTRnovel0.14
UCECchrX153868651Missense_MutationnovelD486Y0.15
UCECchrX153863955Missense_MutationnovelA1129T0.28
UCECchrX153870934Missense_MutationNAR184W0.38
UCECchrX1538623553'UTRrs2002560080.24
UCECchrX153862847Missense_MutationNAG1197E0.22
UCECchrX153867509Missense_MutationnovelW662R0.46
UCECchrX153867547Missense_MutationnovelD649G0.37
UCECchrX153862725Missense_Mutationrs144089789A1238T0.54
UCECchrX153864852Silentrs202082978I1005I0.31
UCECchrX153868679SilentnovelP476P0.26
UCECchrX1538758555'UTRnovel0.42
UCECchrX153872214Missense_Mutationrs781908326R113H0.24
UCECchrX153872315Missense_MutationNAK79N0.3
UCECchrX153884258Intronnovel0.41
UCECchrX1538870265'Flanknovel0.37
UCECchrX1538885065'Flanknovel0.5
UCECchrX153868040Missense_Mutationrs137940405E596K0.09
UCECchrX153865714Missense_Mutationrs149737236R846H0.33
UCECchrX153864452SilentNAS1064S0.24
UCECchrX153864453Missense_Mutationrs782535616S1064L0.19
UCECchrX153875762Splice_RegionnovelE25E0.29
UCECchrX153864446SilentnovelQ1066Q0.31
UCECchrX153868103Missense_MutationnovelR575C0.27
UCECchrX153867845Missense_Mutationrs782367123R632C0.6
UCECchrX153866667Missense_MutationNAG805S0.34
UCECchrX153870080Missense_MutationnovelH323Y0.43
UCECchrX153869562Missense_Mutationrs782132624R409W0.5
UCECchrX153867529Missense_Mutationrs112094935K655R0.5
UCECchrX153868073Missense_MutationNAD585N0.39
UCECchrX1538869765'Flanknovel0.43
UCECchrX153865151Missense_Mutationrs141213959R937C0.22
UCECchrX153869631Missense_MutationNAR386C0.26
UCECchrX153863506SilentNAP1167P0.28
UCECchrX153872651SilentNAV46V0.28
UCECchrX153862777Silentrs782388610N1220N0.45
UCECchrX153862756SilentnovelG1227G0.68
UCECchrX153864954SilentnovelR971R0.38
UCECchrX153866864Missense_MutationNAR739Q0.75
UCECchrX153884252Intronnovel0.75
UCECchrX1538624043'UTRnovel0.29
UCECchrX153864947Missense_Mutationrs782712766E974K0.47
UCECchrX153868688SilentnovelR473R0.36
UCECchrX153871166Frame_Shift_DelnovelA135Qfs*50.42
UCECchrX153862677Missense_Mutationrs200498314V1254M0.38
UCECchrX153864607SilentNAH1048H0.2
UCECchrX153865427Missense_MutationnovelP874L0.33
UCECchrX153868057Missense_MutationNAS590N0.36
UCECchrX153868877Missense_MutationnovelC448Y0.36
UCECchrX153863883Missense_MutationnovelV1153L0.28
UCECchrX153864383Missense_MutationnovelE1087D0.36
UCECchrX153871151SilentnovelV143V0.33
UCECchrX1538870385'Flanknovel0.07
UCSchrX153864016Splice_RegionnovelG1108G0.41
UCSchrX153865817Missense_MutationnovelP812S0.47
UCSchrX153869637Missense_MutationnovelI384V0.11

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.18983.2002e-05
DLBCAMP0.14580.24013
ESCAAMP0.27720.18371
HNSCAMP0.21070.0095371
KIRCAMP0.04360.12739
LIHCAMP0.15140.011319
LUSCAMP0.17560.08275
OVAMP0.31432.176e-06
PAADAMP0.07610.041079
READAMP0.15150.14805
STADAMP0.11110.0021069
TGCTDEL0.06670.08422
THCADEL0.0020.21991
UCECAMP0.09460.010288
UCSDEL0.28570.063955

Survival Analysis
CancerP-value Q-value
KIRC0.00011

Kaplan-Meier Survival Analysis

MESO0.0004

Kaplan-Meier Survival Analysis

ACC0.012

Kaplan-Meier Survival Analysis

HNSC0.0055

Kaplan-Meier Survival Analysis

SKCM0.015

Kaplan-Meier Survival Analysis

LUSC0.0021

Kaplan-Meier Survival Analysis

BRCA0.0045

Kaplan-Meier Survival Analysis

KIRP0.00013

Kaplan-Meier Survival Analysis

PAAD0.04

Kaplan-Meier Survival Analysis

BLCA0.0049

Kaplan-Meier Survival Analysis

KICH0.036

Kaplan-Meier Survival Analysis

UCEC0.0001

Kaplan-Meier Survival Analysis

GBM0.0018

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.045

Kaplan-Meier Survival Analysis

OV0.043

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000198910 (Gene tree)
Gene ID
3897
Gene Symbol
L1CAM
Alias
CD171|HSAS1|SPG1|HSAS|MASA|MIC5|S10
Full Name
L1 cell adhesion molecule
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
24,661 bases
Position
chrX:153,861,514-153,886,174
Accession
6470
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
17150825Identification of antisense RNA stem-loops that inhibit RNA-protein interactions using a bacterial reporter system.Nucleic Acids Symp Ser (Oxf)2006Yano A-
11925449The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo.J Biol Chem2002 Aug 9Shimizu H-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000474853L1CAM-212568--- (aa)--
ENST00000458029L1CAM-210637-ENSP0000039607983 (aa)-E9PHJ4
ENST00000484652L1CAM-213551--- (aa)--
ENST00000407935L1CAM-206576-ENSP00000384902128 (aa)-E7EVM4
ENST00000420165L1CAM-207569-ENSP0000039252490 (aa)-E7EMY4
ENST00000460553L1CAM-211556--- (aa)--
ENST00000370060L1CAM-2055141-ENSP000003590771257 (aa)-P32004
ENST00000491983L1CAM-214608--- (aa)--
ENST00000370055L1CAM-2034655-ENSP000003590721248 (aa)-P32004
ENST00000439496L1CAM-208655-ENSP00000402407150 (aa)-E7EPI4
ENST00000455590L1CAM-209570-ENSP00000397792190 (aa)-H0Y5C3
ENST00000616195L1CAM-216740--- (aa)--
ENST00000361981L1CAM-2025004-ENSP000003547121248 (aa)-P32004
ENST00000496122L1CAM-215561--- (aa)--
ENST00000370058L1CAM-204692-ENSP00000359075153 (aa)-H3BLW5
ENST00000361699L1CAM-2013888-ENSP000003553801253 (aa)-P32004
Gene Model
Click here to download ENSG00000198910's gene model file
Pathways
Pathway IDPathway NameSource
hsa04360Axon guidanceKEGG
hsa04514Cell adhesion molecules (CAMs)KEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198910's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005515protein binding18321067.IPIFunction
GO:0005886plasma membrane21873635.IBAComponent
GO:0005886plasma membrane20621658.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006935chemotaxis19909241.TASProcess
GO:0007155cell adhesion7920659.NASProcess
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules21873635.IBAProcess
GO:0007160cell-matrix adhesion22973895.IDAProcess
GO:0007399nervous system development1769655.TASProcess
GO:0007411axon guidance24155914.IDAProcess
GO:0007411axon guidance-TASProcess
GO:0008046axon guidance receptor activity21873635.IBAFunction
GO:0009986cell surface19581412.HDAComponent
GO:0009986cell surface22973895.IDAComponent
GO:0016021integral component of membrane-IEAComponent
GO:0016477cell migration22973895.IDAProcess
GO:0019904protein domain specific binding18321067.IDAFunction
GO:0030424axon21873635.IBAComponent
GO:0030424axon20621658.IDAComponent
GO:0030425dendrite-IEAComponent
GO:0031175neuron projection development22973895.IDAProcess
GO:0043025neuronal cell body21873635.IBAComponent
GO:0043025neuronal cell body20621658.IDAComponent
GO:0044295axonal growth cone-ISSComponent
GO:0045773positive regulation of axon extension-ISSProcess
GO:0050808synapse organization21873635.IBAProcess
GO:0050808synapse organization24155914.IDAProcess
GO:0050900leukocyte migration-TASProcess
GO:0061564axon development20621658.IDAProcess
GO:0062023collagen-containing extracellular matrix27559042.HDAComponent
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