EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28448495	Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.	PLoS Genet	2017 Apr 27	Jin X	doi: 10.1371/journal.pgen.1006748

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr14	104706101	Frame_Shift_Del	novel	*E257Rfs12**	0.44
BLCA	chr14	104708682	Silent	rs763044552	L633L	0.29
BLCA	chr14	104718862	3'UTR	novel		0.17
BLCA	chr14	104703427	Missense_Mutation	NA	R214C	0.19
BLCA	chr14	104711114	Silent	NA	I782I	0.38
BLCA	chr14	104708708	Missense_Mutation	novel	N642S	0.13
BLCA	chr14	104708475	Missense_Mutation	NA	A592D	0.48
BLCA	chr14	104707938	Silent	novel	V557V	0.13
BLCA	chr14	104707930	Missense_Mutation	novel	R555W	0.37
BLCA	chr14	104706121	Missense_Mutation	NA	S263C	0.36
BLCA	chr14	104706939	Silent	NA	L291L	0.37
BLCA	chr14	104707881	Silent	NA	I538I	0.18
BLCA	chr14	104703411	Silent	rs750610272	P208P	0.13
BLCA	chr14	104715299	Missense_Mutation	NA	S1237F	0.27
BLCA	chr14	104707930	Missense_Mutation	novel	R555W	0.22
BLCA	chr14	104710993	Frame_Shift_Del	novel	*N766Tfs18**	0.18
BLCA	chr14	104712494	Missense_Mutation	rs776939784	E851K	0.17
BRCA	chr14	104714318	Silent	NA	A1052A	0.34
BRCA	chr14	104703358	Missense_Mutation	NA	V191M	0.43
BRCA	chr14	104709291	Missense_Mutation	NA	E654K	0.38
BRCA	chr14	104713233	Silent	rs768008674	A934A	0.08
BRCA	chr14	104710122	Missense_Mutation	novel	E725K	0.31
CESC	chr14	104714378	Silent	NA	L1072L	0.41
CESC	chr14	104713588	Missense_Mutation	novel	P1008S	0.3
CESC	chr14	104712485	Silent	NA	L848L	0.48
CESC	chr14	104703342	Silent	novel	L185L	0.32
CESC	chr14	104712836	Missense_Mutation	NA	I873M	0.52
COAD	chr14	104707848	Frame_Shift_Del	NA	*V530Wfs28**	0.28
COAD	chr14	104711124	Missense_Mutation	NA	L786M	0.17
COAD	chr14	104714597	Silent	rs780026536	A1145A	0.42
COAD	chr14	104703408	Silent	NA	G207G	0.11
COAD	chr14	104709372	Missense_Mutation	rs771072587	E681K	0.25
COAD	chr14	104711116	Missense_Mutation	NA	S783N	0.37
COAD	chr14	104713446	Splice_Region	NA	V960V	0.43
COAD	chr14	104707848	Frame_Shift_Del	NA	*V530Wfs28**	0.32
COAD	chr14	104701602	Missense_Mutation	NA	E79D	0.56
COAD	chr14	104711096	Silent	rs771802606	D776D	0.15
COAD	chr14	104703351	Silent	rs746732992	S188S	1
COAD	chr14	104701401	Silent	NA	A12A	0.44
COAD	chr14	104713269	Silent	NA	E946E	0.16
COAD	chr14	104703203	Missense_Mutation	rs755015990	A164T	0.2
COAD	chr14	104707643	Missense_Mutation	rs766510967	P459L	0.46
COAD	chr14	104707848	Frame_Shift_Del	NA	*V530Wfs28**	0.52
COAD	chr14	104701549	Missense_Mutation	NA	G62S	0.39
COAD	chr14	104714323	Frame_Shift_Del	NA	*G1056Afs31**	0.29
COAD	chr14	104707576	Frame_Shift_Del	novel	*P438Lfs120**	1
COAD	chr14	104707676	Frame_Shift_Del	NA	*P472Qfs86**	0.43
COAD	chr14	104707845	Silent	novel	C526C	0.42
COAD	chr14	104713309	Missense_Mutation	NA	V960F	0.31
COAD	chr14	104701668	Silent	rs779780698	C101C	0.67
COAD	chr14	104701613	Missense_Mutation	NA	R83Q	0.25
COAD	chr14	104714592	Missense_Mutation	rs769598010	E1144K	0.15
COAD	chr14	104703154	Silent	NA	L147L	0.67
COAD	chr14	104714794	Frame_Shift_Del	NA	*G1212Dfs19**	0.9
COAD	chr14	104713232	Missense_Mutation	NA	A934V	0.17
COAD	chr14	104708719	Missense_Mutation	NA	K646E	0.14
COAD	chr14	104714288	Silent	NA	S1042S	0.41
COAD	chr14	104701525	Missense_Mutation	NA	R54C	0.35
COAD	chr14	104701684	Missense_Mutation	NA	A107T	0.24
COAD	chr14	104707918	Missense_Mutation	novel	V551I	0.08
ESCA	chr14	104714368	Missense_Mutation	rs376139171	P1069L	0.85
ESCA	chr14	104706096	Missense_Mutation	novel	D255N	0.34
ESCA	chr14	104712892	Missense_Mutation	novel	E892A	0.1
ESCA	chr14	104711105	Silent	novel	G779G	0.13
GBM	chr14	104711007	Splice_Region	rs758454108	Y770Y	0.62
GBM	chr14	104712994	Splice_Site	novel	X925_splice	0.29
GBM	chr14	104713525	Missense_Mutation	rs777407891	R987W	0.46
HNSC	chr14	104707020	Silent	novel	L318L	0.42
HNSC	chr14	104708486	Missense_Mutation	novel	E596Q	0.26
HNSC	chr14	104718801	3'UTR	novel		0.34
HNSC	chr14	104707977	Silent	novel	Q570Q	0.16
HNSC	chr14	104714738	Silent	novel	S1192S	0.36
HNSC	chr14	104709657	Missense_Mutation	novel	K697M	0.31
KIRP	chr14	104708558	Frame_Shift_Ins	novel	*R622Pfs28**	0.51
KIRP	chr14	104703988	Intron	novel		0.17
LGG	chr14	104707984	Missense_Mutation	NA	P573S	0.33
LGG	chr14	104712878	Silent	NA	E887E	0.36
LGG	chr14	104707999	Missense_Mutation	rs201593594	R578C	0.31
LIHC	chr14	104701683	Silent	novel	R106R	0.25
LIHC	chr14	104714327	Silent	novel	P1055P	0.45
LIHC	chr14	104714503	Missense_Mutation	novel	L1114H	0.42
LIHC	chr14	104708474	Missense_Mutation	rs530285485	A592T	0.18
LUAD	chr14	104708693	Missense_Mutation	novel	K637R	0.14
LUAD	chr14	104703913	Splice_Region	novel		0.33
LUAD	chr14	104709670	Silent	novel	A701A	0.09
LUAD	chr14	104714454	Nonsense_Mutation	novel	E1098*	0.49
LUAD	chr14	104714455	Missense_Mutation	novel	E1098V	0.48
LUAD	chr14	104714806	Missense_Mutation	novel	S1215L	0.24
LUAD	chr14	104703202	Silent	rs769080446	D163D	0.14
LUSC	chr14	104713501	Missense_Mutation	novel	D979N	0.15
LUSC	chr14	104711103	Missense_Mutation	novel	G779C	0.16
LUSC	chr14	104708680	Missense_Mutation	NA	L633I	0.04
LUSC	chr14	104708524	Silent	novel	F608F	0.22
LUSC	chr14	104707363	Nonsense_Mutation	novel	Q366*	0.27
LUSC	chr14	104710944	Silent	novel	L749L	0.25
LUSC	chr14	104712430	Splice_Region	novel		0.1
LUSC	chr14	104709671	Missense_Mutation	novel	D702N	0.18
LUSC	chr14	104704076	Intron	novel		0.33
LUSC	chr14	104703396	Silent	rs140017506	A203A	0.17
LUSC	chr14	104701619	Missense_Mutation	NA	S85L	0.38
LUSC	chr14	104706092	Silent	novel	A253A	0.29
OV	chr14	104714554	Missense_Mutation	novel	A1131G	0.5
OV	chr14	104703435	Missense_Mutation	novel	Q216H	0.5
OV	chr14	104703436	Frame_Shift_Ins	novel	*L217Pfs37**	0.4
PAAD	chr14	104701700	Missense_Mutation	novel	R112Q	0.08
PAAD	chr14	104714351	Frame_Shift_Ins	novel	*L1064Ffs26**	0.22
PAAD	chr14	104704044	Intron	novel		0.09
PAAD	chr14	104707887	Silent	novel	A540A	0.16
PAAD	chr14	104711649	Silent	rs543495305	P813P	0.16
PAAD	chr14	104712875	Silent	novel	I886I	0.15
PAAD	chr14	104713577	Missense_Mutation	novel	S1004F	0.18
PAAD	chr14	104714385	Missense_Mutation	rs376685243	R1075C	0.16
PAAD	chr14	104714752	Missense_Mutation	rs372714774	A1197V	0.17
PRAD	chr14	104712983	Silent	rs201044782	R922R	0.35
READ	chr14	104712889	Missense_Mutation	rs777498088	R891Q	0.29
SARC	chr14	104708696	Missense_Mutation	novel	S638I	0.06
SARC	chr14	104714513	Silent	novel	S1117S	0.15
SARC	chr14	104711118	Missense_Mutation	novel	T784P	0.46
SARC	chr14	104712456	Nonsense_Mutation	novel	S838*	0.45
SARC	chr14	104718914	3'UTR	novel		0.36
SKCM	chr14	104708458	Silent	NA	S586S	0.38
SKCM	chr14	104709702	Missense_Mutation	NA	P712L	0.33
SKCM	chr14	104712841	Missense_Mutation	novel	A875V	0.11
SKCM	chr14	104703160	Silent	NA	A149A	0.23
SKCM	chr14	104706967	Silent	NA	L301L	0.32
SKCM	chr14	104714462	Silent	rs755319597	A1100A	0.2
SKCM	chr14	104703362	Missense_Mutation	novel	P192L	0.33
SKCM	chr14	104714569	Missense_Mutation	NA	S1136F	0.23
SKCM	chr14	104709365	Silent	NA	L678L	0.21
SKCM	chr14	104714466	Missense_Mutation	novel	P1102S	0.38
SKCM	chr14	104714569	Missense_Mutation	NA	S1136F	0.3
SKCM	chr14	104707989	Silent	NA	S574S	0.14
SKCM	chr14	104711629	Nonsense_Mutation	NA	E807*	0.74
SKCM	chr14	104708468	Missense_Mutation	novel	P590S	0.41
SKCM	chr14	104715287	Missense_Mutation	NA	V1233A	0.07
SKCM	chr14	104708520	Missense_Mutation	novel	S607F	0.29
SKCM	chr14	104708521	Silent	NA	S607S	0.5
SKCM	chr14	104712513	Missense_Mutation	NA	S857F	0.37
SKCM	chr14	104707027	Missense_Mutation	NA	R321W	0.39
SKCM	chr14	104709702	Missense_Mutation	NA	P712L	0.41
SKCM	chr14	104709371	Silent	rs373736329	P680P	0.4
SKCM	chr14	104711089	Missense_Mutation	novel	T774I	0.4
SKCM	chr14	104712981	Missense_Mutation	rs775431460	R922C	0.53
STAD	chr14	104707848	Frame_Shift_Del	NA	*V530Wfs28**	0.4
STAD	chr14	104707848	Frame_Shift_Del	NA	*V530Wfs28**	0.25
STAD	chr14	104707848	Frame_Shift_Del	NA	*V530Wfs28**	0.62
STAD	chr14	104711695	Missense_Mutation	NA	A829T	0.48
STAD	chr14	104707980	Silent	NA	K571K	0.31
STAD	chr14	104713543	Missense_Mutation	novel	R993C	0.16
STAD	chr14	104718915	3'UTR	novel		0.3
STAD	chr14	104707848	Frame_Shift_Del	NA	*V530Wfs28**	0.5
STAD	chr14	104703412	Missense_Mutation	novel	E209K	0.26
STAD	chr14	104707848	Frame_Shift_Del	NA	*V530Wfs28**	0.43
STAD	chr14	104708559	Frame_Shift_Del	NA	*R622Gfs18**	0.38
STAD	chr14	104707848	Frame_Shift_Del	NA	*V530Wfs28**	0.35
STAD	chr14	104707848	Frame_Shift_Del	NA	*V530Wfs28**	0.32
STAD	chr14	104707848	Frame_Shift_Del	NA	*V530Wfs28**	0.29
STAD	chr14	104708559	Frame_Shift_Del	NA	*R622Gfs18**	0.32
STAD	chr14	104707934	Missense_Mutation	rs753323267	R556Q	0.3
STAD	chr14	104703351	Silent	rs746732992	S188S	0.18
STAD	chr14	104712498	Missense_Mutation	rs372129830	R852Q	0.15
THCA	chr14	104706983	Missense_Mutation	rs777010216	R306H	0.38
THCA	chr14	104708688	Silent	NA	A635A	0.06
UCEC	chr14	104712956	Missense_Mutation	NA	M913I	0.2
UCEC	chr14	104714416	Missense_Mutation	NA	V1085G	0.2
UCEC	chr14	104707306	Nonsense_Mutation	novel	R347*	0.13
UCEC	chr14	104711188	Splice_Site	novel	X806_splice	0.21
UCEC	chr14	104712915	Missense_Mutation	novel	D900N	0.21
UCEC	chr14	104713485	Silent	NA	I973I	0.23
UCEC	chr14	104707859	Missense_Mutation	rs200386025	A531V	0.35
UCEC	chr14	104703384	Silent	rs372269719	S199S	0.42
UCEC	chr14	104701502	Missense_Mutation	novel	S46Y	0.47
UCEC	chr14	104701630	Missense_Mutation	rs765566674	V89I	0.44
UCEC	chr14	104712515	Missense_Mutation	rs201292830	V858M	0.41
UCEC	chr14	104707317	Silent	rs750840228	P350P	0.34
UCEC	chr14	104708510	Nonsense_Mutation	NA	R604*	0.26
UCEC	chr14	104714502	Missense_Mutation	NA	L1114I	0.32
UCEC	chr14	104703444	Silent	novel	N219N	0.35
UCEC	chr14	104711164	Missense_Mutation	NA	T799M	0.16
UCEC	chr14	104718870	3'UTR	novel		0.16
UCEC	chr14	104707999	Missense_Mutation	rs201593594	R578C	0.34
UCEC	chr14	104709381	Missense_Mutation	novel	E684K	0.45
UCEC	chr14	104710960	Missense_Mutation	novel	P755S	0.42
UCEC	chr14	104714330	Silent	novel	G1056G	0.38
UCEC	chr14	104711007	Splice_Region	rs758454108	Y770Y	0.29
UCEC	chr14	104711140	Missense_Mutation	novel	T791I	0.54
UCEC	chr14	104714698	Missense_Mutation	rs747890405	T1179M	0.39
UCEC	chr14	104706057	Silent	NA	L242L	0.35
UCEC	chr14	104711667	Silent	novel	P819P	0.33
UCEC	chr14	104703428	Missense_Mutation	rs267606879	R214H	0.47
UCEC	chr14	104701711	Missense_Mutation	novel	E116K	0.86
UCEC	chr14	104703317	Missense_Mutation	novel	R177H	0.08
UCEC	chr14	104701594	Silent	novel	L77L	0.25
UCEC	chr14	104707848	Frame_Shift_Del	NA	*V530Wfs28**	0.32
UCEC	chr14	104703975	Intron	novel		0.43
UCEC	chr14	104711134	Missense_Mutation	novel	T789M	0.11
UCEC	chr14	104709357	Missense_Mutation	novel	L676I	0.33
UCEC	chr14	104703184	Silent	novel	G157G	0.27
UCEC	chr14	104703402	Silent	novel	I205I	0.31
UCEC	chr14	104711670	Silent	novel	R820R	0.07
UCEC	chr14	104701684	Missense_Mutation	NA	A107T	0.15
UCEC	chr14	104703317	Missense_Mutation	novel	R177H	0.28
UCEC	chr14	104701474	Missense_Mutation	novel	L37M	0.38
UCEC	chr14	104703421	Missense_Mutation	rs748481552	R212C	0.39
UCEC	chr14	104714218	Missense_Mutation	novel	P1019H	0.27
UCEC	chr14	104703424	Missense_Mutation	rs778267218	A213T	0.25
UCEC	chr14	104712944	Silent	NA	T909T	0.39
UCEC	chr14	104709676	Missense_Mutation	NA	H703Q	0.31
UCEC	chr14	104703933	Missense_Mutation	rs752058170	V229I	0.52
UCEC	chr14	104712827	Splice_Site	novel	X871_splice	0.57

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2278	1.4717e-06
CESC	DEL	0.1424	0.00086239
CHOL	DEL	0.5556	0.00040262
COAD	DEL	0.2838	0.050084
GBM	AMP	0.0364	0.060522
GBM	DEL	0.2426	5.7274e-07
HNSC	DEL	0.1111	0.0057325
KIRC	DEL	0.3788	0.0074281
KIRP	DEL	0.1701	0.085174
LIHC	DEL	0.327	8.4799e-08
LUAD	DEL	0.2054	0.0018747
LUSC	AMP	0.2355	0.064655
MESO	DEL	0.4023	0.088547
OV	AMP	0.2055	0.0046435
PAAD	DEL	0.0761	0.11332
READ	DEL	0.3636	0.189
SKCM	DEL	0.2752	0.10277
STAD	DEL	0.2268	0.0031145

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0096	Kaplan-Meier Survival Analysis
KIRC	0.013	Kaplan-Meier Survival Analysis
SARC	0.014	Kaplan-Meier Survival Analysis
MESO	0.025	Kaplan-Meier Survival Analysis
HNSC	0.0062	Kaplan-Meier Survival Analysis
LUSC	0.03	Kaplan-Meier Survival Analysis
COAD	0.049	Kaplan-Meier Survival Analysis
PAAD	0.028	Kaplan-Meier Survival Analysis
LAML	0.0035	Kaplan-Meier Survival Analysis
UCEC	0.003	Kaplan-Meier Survival Analysis
GBM	0.023	Kaplan-Meier Survival Analysis
LIHC	0.0013	Kaplan-Meier Survival Analysis
LUAD	0.042	Kaplan-Meier Survival Analysis
UVM	0.017	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000203485 (Gene tree)
Gene ID: 64423
Gene Symbol: INF2
Alias: MGC13251|C14orf151|C14orf173
Full Name: inverted formin, FH2 and WH2 domain containing
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 32,930 bases
Position: chr14:104,689,606-104,722,535
Accession: 23791
RBP type: non-canonical RBP
Summary: This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000617571	INF2-209	2956	-	ENSP00000483829	142 (aa)	-	Q8WYS3
ENST00000474229	INF2-205	947	-	-	- (aa)	-	-
ENST00000481338	INF2-208	1102	-	-	- (aa)	-	-
ENST00000398337	INF2-204	1689	-	ENSP00000381380	234 (aa)	-	Q27J81
ENST00000252527	INF2-201	3050	-	ENSP00000252527	717 (aa)	-	A0A0A0MQU1
ENST00000330634	INF2-202	7578	XM_005268005	ENSP00000376406	1240 (aa)	XP_005268062	Q27J81
ENST00000392634	INF2-203	4672	XM_005268004	ENSP00000376410	1249 (aa)	XP_005268061	Q27J81
ENST00000480763	INF2-207	581	-	-	- (aa)	-	-
ENST00000477497	INF2-206	545	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000203485's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000203485	Platelet Function Tests	1.4538600E-005	-
ENSG00000203485	Platelet Function Tests	1.5727600E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000203485's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003779	actin binding	-	IEA	Function
GO:0017048	Rho GTPase binding	-	IEA	Function
GO:0030036	actin cytoskeleton organization	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	20023659.	IDA	Component
GO:0090140	regulation of mitochondrial fission	23349293.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.