EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23079975	Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population.	Genet Mol Res	2012 Dec 17	Pan Q	doi: 10.4238/2012.September.17.1.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr6	31901176	Frame_Shift_Del	novel	*K43Ffs21**	0.31
BLCA	chr6	31899963	Missense_Mutation	NA	E448V	0.39
BLCA	chr6	31900077	Missense_Mutation	novel	S410L	0.43
BLCA	chr6	31901282	Silent	novel	L8L	0.61
BLCA	chr6	31900275	Missense_Mutation	novel	G344D	0.09
BLCA	chr6	31901021	Silent	novel	F95F	0.15
BLCA	chr6	31900903	Missense_Mutation	NA	E135Q	0.32
BRCA	chr6	31900218	Missense_Mutation	rs762290440	R363H	0.04	zf-C2H2
BRCA	chr6	31901005	Missense_Mutation	NA	V101F	0.25
BRCA	chr6	31900059	Missense_Mutation	rs749307616	R416H	0.21
CESC	chr6	31900973	Silent	NA	Q111Q	0.16
CESC	chr6	31900170	Missense_Mutation	novel	N379S	0.32	zf-C2H2
CESC	chr6	31901101	Missense_Mutation	novel	E69K	0.07
CESC	chr6	31900947	Missense_Mutation	rs756745454	R120Q	0.4
COAD	chr6	31900249	Missense_Mutation	novel	R353W	0.15
COAD	chr6	31901312	5'UTR	novel		0.38
COAD	chr6	31900211	Silent	novel	G365G	0.31
COAD	chr6	31899977	Silent	novel	A443A	0.54
COAD	chr6	31900707	Missense_Mutation	novel	D200G	0.45
COAD	chr6	31899916	3'UTR	novel		0.44
COAD	chr6	31900804	Missense_Mutation	NA	P168S	0.52
COAD	chr6	31901131	Missense_Mutation	NA	R59W	0.07
COAD	chr6	31901189	Silent	NA	A39A	0.23
COAD	chr6	31900547	Frame_Shift_Del	NA	*S254Afs3**	0.35
ESCA	chr6	31900387	Frame_Shift_Del	novel	*A307Rfs24**	0.3
ESCA	chr6	31900579	Frame_Shift_Ins	novel	*L243Tfs15**	0.44
GBM	chr6	31900180	Missense_Mutation	novel	R376C	0.28	zf-C2H2
GBM	chr6	31900241	Missense_Mutation	novel	Q355H	0.4
GBM	chr6	31900097	Silent	novel	H403H	0.41
HNSC	chr6	31900546	Frame_Shift_Ins	novel	*S254Qfs15**	0.19
HNSC	chr6	31900219	Missense_Mutation	rs796344107	R363C	0.25	zf-C2H2
HNSC	chr6	31900307	Missense_Mutation	novel	I333M	0.25
KIRC	chr6	31900949	Silent	NA	C119C	0.17
KIRC	chr6	31900112	Missense_Mutation	NA	Q398H	0.53
KIRP	chr6	31900972	Missense_Mutation	novel	M112L	0.58
LAML	chr6	31900911	Missense_Mutation	novel	G132D	0.36
LIHC	chr6	31900694	In_Frame_Ins	rs764477797	E203_D204dup	0.33
LIHC	chr6	31900364	Silent	novel	G314G	0.23
LIHC	chr6	31900958	Silent	novel	V116V	0.18
LUAD	chr6	31900903	Missense_Mutation	NA	E135Q	0.52
LUAD	chr6	31901228	Silent	NA	L26L	0.09
LUAD	chr6	31901159	Silent	novel	V49V	0.15
LUAD	chr6	31900947	Missense_Mutation	novel	R120L	0.28
LUSC	chr6	31901121	Missense_Mutation	NA	F62S	0.15
LUSC	chr6	31900744	Missense_Mutation	NA	E188K	0.24
LUSC	chr6	31901221	Missense_Mutation	NA	E29K	0.23
LUSC	chr6	31899970	Missense_Mutation	novel	V446M	0.42
LUSC	chr6	31900787	Silent	novel	P173P	0.45
LUSC	chr6	31899882	3'UTR	rs751947427		0.25
LUSC	chr6	31900924	Nonsense_Mutation	novel	E128*	0.31
OV	chr6	31901009	Missense_Mutation	NA	D99E	0.14
PRAD	chr6	31900011	Missense_Mutation	NA	R432Q	0.36
READ	chr6	31899921	3'UTR	rs540651243		0.52
SARC	chr6	31900544	Missense_Mutation	rs753644043	S254R	0.41
SKCM	chr6	31900273	Missense_Mutation	NA	V345M	0.26
SKCM	chr6	31900592	Silent	NA	S238S	0.28
SKCM	chr6	31900593	Missense_Mutation	novel	S238F	0.28
SKCM	chr6	31900482	Missense_Mutation	NA	G275E	0.16
SKCM	chr6	31900592	Silent	NA	S238S	0.4
SKCM	chr6	31900657	Silent	novel	L217L	0.26
SKCM	chr6	31900667	Silent	NA	V213V	0.43
STAD	chr6	31899838	3'UTR	novel		0.29
STAD	chr6	31901139	Missense_Mutation	NA	P56H	0.22
STAD	chr6	31900668	Missense_Mutation	NA	V213A	0.38
STAD	chr6	31901070	Missense_Mutation	NA	R79H	0.27
STAD	chr6	31900661	Silent	rs370274844	S215S	0.4
STAD	chr6	31900611	Frame_Shift_Del	novel	*G232Vfs25**	0.24
STAD	chr6	31900213	Missense_Mutation	novel	G365C	0.2	zf-C2H2
STAD	chr6	31900949	Silent	NA	C119C	0.13
THCA	chr6	31900360	Frame_Shift_Del	novel	*S316Afs15**	0.09
UCEC	chr6	31900245	Missense_Mutation	NA	A354V	0.33
UCEC	chr6	31900042	Missense_Mutation	novel	V422M	0.12
UCEC	chr6	31900660	Missense_Mutation	novel	A216T	0.3
UCEC	chr6	31900046	Silent	novel	C420C	0.42
UCEC	chr6	31899981	Missense_Mutation	novel	T442M	0.38
UCEC	chr6	31901102	Silent	novel	S68S	0.38
UCEC	chr6	31901201	Silent	NA	V35V	0.25
UCEC	chr6	31899931	Missense_Mutation	novel	R459C	0.28
UCEC	chr6	31900556	Silent	novel	S250S	0.2
UCEC	chr6	31900964	Silent	rs749911963	H114H	0.33
UCEC	chr6	31901219	Missense_Mutation	novel	E29D	0.14
UCEC	chr6	31900046	Silent	novel	C420C	0.63
UCEC	chr6	31899838	3'UTR	novel		0.36
UCEC	chr6	31900284	Missense_Mutation	rs369788796	V341A	0.36
UCEC	chr6	31900169	Silent	NA	N379N	0.36
UCEC	chr6	31900274	Silent	NA	G344G	0.22
UCEC	chr6	31899970	Missense_Mutation	novel	V446M	0.38
UCEC	chr6	31900483	Missense_Mutation	novel	G275W	0.38
UCEC	chr6	31899924	3'UTR	novel		0.45
UCEC	chr6	31900653	Missense_Mutation	novel	E218A	0.37
UCEC	chr6	31900863	Missense_Mutation	novel	S148I	0.28
UCEC	chr6	31900862	Silent	rs768825206	S148S	0.23

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.1042	0.011841

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00027	Kaplan-Meier Survival Analysis
SARC	0.0017	Kaplan-Meier Survival Analysis
ACC	0.011	Kaplan-Meier Survival Analysis
SKCM	0.014	Kaplan-Meier Survival Analysis
COAD	0.041	Kaplan-Meier Survival Analysis
BLCA	0.0086	Kaplan-Meier Survival Analysis
READ	0.0015	Kaplan-Meier Survival Analysis
LAML	0.00011	Kaplan-Meier Survival Analysis
LIHC	0.0034	Kaplan-Meier Survival Analysis
LGG	0.0039	Kaplan-Meier Survival Analysis
CHOL	0.02	Kaplan-Meier Survival Analysis
UVM	0.00031	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000204366 (Gene tree)
Gene ID: 221527
Gene Symbol: ZBTB12
Alias: G10|NG35|D6S59E|C6orf46
Full Name: zinc finger and BTB domain containing 12
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 3,164 bases
Position: chr6:31,899,204-31,902,367
Accession: 19066
RBP type: canonical RBP
Summary: ZBTB12 (Zinc Finger And BTB Domain Containing 12) is a Protein Coding gene. An important paralog of this gene is ZBTB26.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000364677	zf-C2H2	PF00096.26	3.2e-13	1	2
ENSP00000364677	zf-C2H2	PF00096.26	3.2e-13	2	2
ENSP00000364677	zf-met	PF12874.7	0.00019	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000375527	ZBTB12-201	1875	XM_011514383	ENSP00000364677	459 (aa)	XP_011512685	Q9Y330

Gene Model

Click here to download ENSG00000204366's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000204366	Lupus Erythematosus, Systemic	2.8947E-18	18204098
ENSG00000204366	Diabetes Mellitus, Type 1	1.6E-86	19430480
ENSG00000204366	Lupus Erythematosus, Systemic	4.2E-8	18204446
ENSG00000204366	Lupus Erythematosus, Systemic	8E-21	24871463
ENSG00000204366	Vaccine Potency	1E-17	21764829
ENSG00000204366	Surveys and Questionnaires	6E-6	22566634

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000204366	rs114508013	6	31900988	G	Blood protein levels	30072576	[NR] unit increase	1.5771569	EFO_0007937
ENSG00000204366	rs114508013	6	31900988	G	Blood protein levels	30072576	[NR] unit increase	1.1050375	EFO_0007937
ENSG00000204366	rs114508013	6	31900988	G	Blood protein levels	30072576	[NR] unit increase	0.89926857	EFO_0007937
ENSG00000204366	rs114508013	6	31900988	G	Blood protein levels	30072576	[NR] unit decrease	0.5455914	EFO_0007937
ENSG00000204366	rs114508013	6	31900988	G	Blood protein levels	30072576	[NR] unit decrease	0.51218635	EFO_0007937
ENSG00000204366	rs114508013	6	31900988	G	Blood protein levels	30072576	[NR] unit increase	0.45406085	EFO_0007937
ENSG00000204366	rs114508013	6	31900988	G	Blood protein levels	30072576	[1.04-1.31] unit increase	1.176	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204366's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000204366	ZBTB12	100	96.296	ENSAMEG00000012921	ZBTB12	100	96.296	Ailuropoda_melanoleuca
ENSG00000204366	ZBTB12	100	64.571	ENSACAG00000011189	ZBTB12	100	64.397	Anolis_carolinensis
ENSG00000204366	ZBTB12	100	99.782	ENSANAG00000019564	ZBTB12	100	99.782	Aotus_nancymaae
ENSG00000204366	ZBTB12	100	98.911	ENSBTAG00000032031	ZBTB12	100	98.911	Bos_taurus
ENSG00000204366	ZBTB12	100	99.564	ENSCJAG00000044185	ZBTB12	100	99.564	Callithrix_jacchus
ENSG00000204366	ZBTB12	100	98.475	ENSCAFG00000000674	ZBTB12	100	98.475	Canis_familiaris
ENSG00000204366	ZBTB12	100	98.475	ENSCAFG00020000911	ZBTB12	100	98.475	Canis_lupus_dingo
ENSG00000204366	ZBTB12	100	98.911	ENSCHIG00000007636	ZBTB12	100	98.911	Capra_hircus
ENSG00000204366	ZBTB12	100	99.346	ENSCCAG00000019304	ZBTB12	100	99.346	Cebus_capucinus
ENSG00000204366	ZBTB12	100	98.911	ENSCLAG00000007108	ZBTB12	100	98.911	Chinchilla_lanigera
ENSG00000204366	ZBTB12	99	65.605	ENSCPBG00000012202	ZBTB12	99	67.797	Chrysemys_picta_bellii
ENSG00000204366	ZBTB12	100	98.475	ENSCANG00000038177	ZBTB12	100	98.475	Colobus_angolensis_palliatus
ENSG00000204366	ZBTB12	100	95.474	ENSCGRG00001002052	Zbtb12	100	95.474	Cricetulus_griseus_chok1gshd
ENSG00000204366	ZBTB12	53	67.717	ENSDARG00000103949	zbtb12.1	51	67.717	Danio_rerio
ENSG00000204366	ZBTB12	100	98.475	ENSEASG00005015654	ZBTB12	100	98.475	Equus_asinus_asinus
ENSG00000204366	ZBTB12	100	98.475	ENSECAG00000034980	ZBTB12	100	98.475	Equus_caballus
ENSG00000204366	ZBTB12	100	98.693	ENSFCAG00000031296	ZBTB12	100	98.693	Felis_catus
ENSG00000204366	ZBTB12	77	95.122	ENSFDAG00000018453	ZBTB12	99	96.855	Fukomys_damarensis
ENSG00000204366	ZBTB12	99	65.678	ENSGAGG00000002344	ZBTB12	99	67.511	Gopherus_agassizii
ENSG00000204366	ZBTB12	100	99.346	ENSGGOG00000015638	ZBTB12	100	99.346	Gorilla_gorilla
ENSG00000204366	ZBTB12	100	98.911	ENSHGLG00000016731	ZBTB12	100	98.911	Heterocephalus_glaber_female
ENSG00000204366	ZBTB12	100	98.911	ENSSTOG00000027411	ZBTB12	100	98.911	Ictidomys_tridecemlineatus
ENSG00000204366	ZBTB12	99	60.752	ENSLACG00000006007	ZBTB12	99	60.970	Latimeria_chalumnae
ENSG00000204366	ZBTB12	100	99.782	ENSMFAG00000010877	ZBTB12	100	99.782	Macaca_fascicularis
ENSG00000204366	ZBTB12	100	99.782	ENSMMUG00000011683	ZBTB12	100	99.782	Macaca_mulatta
ENSG00000204366	ZBTB12	100	99.782	ENSMNEG00000022456	ZBTB12	100	99.782	Macaca_nemestrina
ENSG00000204366	ZBTB12	100	96.739	ENSMAUG00000008051	Zbtb12	100	96.739	Mesocricetus_auratus
ENSG00000204366	ZBTB12	100	99.129	ENSMICG00000003600	ZBTB12	100	99.129	Microcebus_murinus
ENSG00000204366	ZBTB12	100	97.168	ENSMOCG00000002711	Zbtb12	100	97.168	Microtus_ochrogaster
ENSG00000204366	ZBTB12	99	81.761	ENSMODG00000015096	-	96	81.132	Monodelphis_domestica
ENSG00000204366	ZBTB12	100	97.386	MGP_CAROLIEiJ_G0021482	Zbtb12	100	97.386	Mus_caroli
ENSG00000204366	ZBTB12	100	97.386	ENSMUSG00000049823	Zbtb12	100	97.386	Mus_musculus
ENSG00000204366	ZBTB12	100	97.168	MGP_PahariEiJ_G0020477	Zbtb12	100	97.168	Mus_pahari
ENSG00000204366	ZBTB12	100	97.386	MGP_SPRETEiJ_G0022387	Zbtb12	100	97.386	Mus_spretus
ENSG00000204366	ZBTB12	100	98.911	ENSMPUG00000018357	ZBTB12	100	98.911	Mustela_putorius_furo
ENSG00000204366	ZBTB12	100	96.514	ENSNGAG00000011842	Zbtb12	100	96.514	Nannospalax_galili
ENSG00000204366	ZBTB12	100	99.782	ENSNLEG00000034429	ZBTB12	100	99.782	Nomascus_leucogenys
ENSG00000204366	ZBTB12	100	97.821	ENSODEG00000017709	ZBTB12	100	97.821	Octodon_degus
ENSG00000204366	ZBTB12	100	99.346	ENSOGAG00000031042	ZBTB12	100	99.346	Otolemur_garnettii
ENSG00000204366	ZBTB12	100	94.553	ENSPPAG00000033581	ZBTB12	100	95.207	Pan_paniscus
ENSG00000204366	ZBTB12	100	98.693	ENSPPRG00000000449	ZBTB12	100	98.693	Panthera_pardus
ENSG00000204366	ZBTB12	100	99.564	ENSPTRG00000017993	ZBTB12	100	99.564	Pan_troglodytes
ENSG00000204366	ZBTB12	100	99.564	ENSPANG00000003484	ZBTB12	100	99.564	Papio_anubis
ENSG00000204366	ZBTB12	64	99.658	ENSPPYG00000016468	-	100	99.658	Pongo_abelii
ENSG00000204366	ZBTB12	100	99.346	ENSPCOG00000013160	ZBTB12	100	99.346	Propithecus_coquereli
ENSG00000204366	ZBTB12	100	98.475	ENSPVAG00000005130	ZBTB12	100	98.475	Pteropus_vampyrus
ENSG00000204366	ZBTB12	100	97.821	ENSRNOG00000000418	Zbtb12	100	97.821	Rattus_norvegicus
ENSG00000204366	ZBTB12	99	74.890	ENSSHAG00000008383	ZBTB12	97	72.907	Sarcophilus_harrisii
ENSG00000204366	ZBTB12	94	75.221	ENSSPUG00000013016	ZBTB12	82	75.325	Sphenodon_punctatus
ENSG00000204366	ZBTB12	100	99.129	ENSSSCG00000001421	ZBTB12	100	99.129	Sus_scrofa
ENSG00000204366	ZBTB12	100	97.216	ENSUAMG00000024479	ZBTB12	100	97.216	Ursus_americanus
ENSG00000204366	ZBTB12	100	98.475	ENSVVUG00000022537	ZBTB12	100	98.475	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.