EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25169537	Association between the HSPA1B ??1267A/G polymorphism and cancer risk: a meta-analysis of 14 case-control studies.	Asian Pac J Cancer Prev	2014	Kuang D	-
22883735	[Effects of heat shock protein 70-2 gene polymorphisms on the transcription of HSP 70-2 mRNA and the translation of HSP 70 protein in lung cancer].	Zhonghua Yu Fang Yi Xue Za Zhi	2012 May	Lu HQ	-
22468780	Tumor cell expression of heat shock protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts survival in small Cell lung cancer (SCLC) patients.	Cancer Invest	2012 May	Szondy K	doi: 10.3109/07357907.2012.657815
23065205	HSP90, HSPA8, HIF-1 alpha and HSP70-2 polymorphisms in breast cancer: a case-control study.	Mol Biol Rep	2012 Dec	Zagouri F	doi: 10.1007/s11033-012-1984-2
20043082	Regulation of heat shock protein 70-1 expression by androgen receptor and its signaling in human prostate cancer cells.	Int J Oncol	2010 Feb	Lu S	-
18844219	Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia.	Int J Cancer	2009 Jan 15	Huang WJ	doi: 10.1002/ijc.23906.
22037874	Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations.	Cancer Res	2011 Dec 15	Guo H	doi: 10.1158/0008-5472.CAN-11-1409
18478330	Protective role of genetic polymorphism of heat shock protein 70-2 for gastric cancer risk.	Dig Dis Sci	2009 Jan	Shibata T	doi: 10.1007/s10620-008-0313-z
19626584	Polymorphisms in TNF and HSP-70 show a significant association with gastric cancer and duodenal ulcer.	Int J Cancer	2010 Apr 15	Partida-Rodr??guez O	doi: 10.1002/ijc.24773.
27473057	Heat shock protein 70-2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth.	BMC Cancer	2016 Jul 29	Jagadish N	doi: 10.1186/s12885-016-2592-7.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	31827978	Missense_Mutation	novel	D10N	0.29
BLCA	chr6	31827922	5'UTR	novel		0.24
BLCA	chr6	31827857	5'UTR	novel		0.26
BLCA	chr6	31829907	3'UTR	novel		0.16
BLCA	chr6	31830037	3'UTR	novel		0.75
BLCA	chr6	31829654	Silent	novel	K568K	0.13
BLCA	chr6	31828002	Missense_Mutation	novel	V18M	0.38
BLCA	chr6	31829676	Missense_Mutation	novel	E576Q	0.22
BRCA	chr6	31829965	3'UTR	novel		0.15
BRCA	chr6	31827955	Missense_Mutation	rs199562339	A2V	0.45
CESC	chr6	31829866	Missense_Mutation	novel	E639G	0.28
CESC	chr6	31827971	Missense_Mutation	novel	I7M	0.21
CESC	chr6	31830053	3'UTR	novel		0.26
CESC	chr6	31827880	5'UTR	novel		0.62
CESC	chr6	31829654	Missense_Mutation	rs757789364	K568N	0.33
COAD	chr6	31828051	Missense_Mutation	novel	G34D	0.19
COAD	chr6	31827915	5'UTR	rs760195475		0.16
COAD	chr6	31828021	Missense_Mutation	NA	G24D	0.31
COAD	chr6	31830217	3'UTR	novel		0.67
COAD	chr6	31829612	Missense_Mutation	novel	E554D	0.06
COAD	chr6	31829689	In_Frame_Del	novel	W580del	0.02
ESCA	chr6	31827770	5'UTR	rs572178551		0.64
ESCA	chr6	31828065	Missense_Mutation	novel	P39S	0.61
ESCA	chr6	31829644	Missense_Mutation	novel	A565G	0.13
ESCA	chr6	31829717	Silent	novel	K589K	0.38
GBM	chr6	31829912	3'UTR	novel		0.39
HNSC	chr6	31829816	Silent	novel	F622F	0.5
KIRP	chr6	31829892	3'UTR	novel		0.48
LGG	chr6	31827885	5'UTR	novel		0.63
LGG	chr6	31829871	Missense_Mutation	novel	D641Y	0.08
LUAD	chr6	31829955	3'UTR	novel		0.1
LUAD	chr6	31829875	Frame_Shift_Ins	novel		0.29
LUAD	chr6	31829926	3'UTR	novel		0.08
LUSC	chr6	31829885	3'UTR	novel		0.1
LUSC	chr6	31827897	5'UTR	novel		0.19
LUSC	chr6	31829907	3'UTR	novel		0.38
LUSC	chr6	31827994	Missense_Mutation	novel	Y15S	0.53
MESO	chr6	31827771	5'UTR	rs36058616		0.12
OV	chr6	31829857	Missense_Mutation	NA	T636N	0.5
PAAD	chr6	31828126	Missense_Mutation	novel	V59A	0.11
PRAD	chr6	31829711	Silent	rs754714469	A587A	0.14
READ	chr6	31829883	3'UTR	novel		0.07
SARC	chr6	31829522	Missense_Mutation	novel	K524N	0.15
STAD	chr6	31829779	Missense_Mutation	novel	L610R	0.41
STAD	chr6	31828145	Silent	novel	N65N	0.43
UCEC	chr6	31827938	5'UTR	novel		0.09
UCEC	chr6	31827826	5'UTR	novel		0.2
UCEC	chr6	31830029	3'UTR	novel		0.56
UCEC	chr6	31827984	Missense_Mutation	novel	G12S	0.13
UCEC	chr6	31830139	3'UTR	novel		0.16
UCEC	chr6	31829615	Silent	novel	D555D	0.6
UCS	chr6	31829505	Missense_Mutation	novel	V519L	0.27

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.1042	0.011841

Survival Analysis

Cancer	P-value	Q-value
THYM	0.014	Kaplan-Meier Survival Analysis
SARC	0.039	Kaplan-Meier Survival Analysis
MESO	0.0039	Kaplan-Meier Survival Analysis
UCS	0.034	Kaplan-Meier Survival Analysis
ESCA	0.048	Kaplan-Meier Survival Analysis
KIRP	0.033	Kaplan-Meier Survival Analysis
COAD	0.012	Kaplan-Meier Survival Analysis
BLCA	0.029	Kaplan-Meier Survival Analysis
LAML	0.00012	Kaplan-Meier Survival Analysis
LIHC	0.0033	Kaplan-Meier Survival Analysis
LGG	0.0007	Kaplan-Meier Survival Analysis
THCA	0.011	Kaplan-Meier Survival Analysis
LUAD	0.02	Kaplan-Meier Survival Analysis
UVM	0.0043	Kaplan-Meier Survival Analysis
OV	0.028	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000204388 (Gene tree)
Gene ID: 3304
Gene Symbol: HSPA1B
Alias: HSP70-2
Full Name: heat shock protein family A (Hsp70) member 1B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 2,521 bases
Position: chr6:31,827,735-31,830,255
Accession: 5233
RBP type: non-canonical RBP
Summary: This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000375650	HSPA1B-201	2521	-	ENSP00000364801	641 (aa)	-	P0DMV9

Gene Model

Click here to download ENSG00000204388's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG
hsa04010	MAPK signaling pathway	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa04144	Endocytosis	KEGG
hsa04213	Longevity regulating pathway - multiple species	KEGG
hsa04612	Antigen processing and presentation	KEGG
hsa04915	Estrogen signaling pathway	KEGG
hsa05134	Legionellosis	KEGG
hsa05145	Toxoplasmosis	KEGG
hsa05162	Measles	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000204388	Diabetes Mellitus, Type 1	3.26E-99	19430480
ENSG00000204388	Lupus Erythematosus, Systemic	8.14E-6	18204446
ENSG00000204388	Hypertension	9.2230137E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204388's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000204388	HSPA1B	100	93.458	ENSMUSG00000090877	Hspa1b	95	95.745	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000151	ubiquitin ligase complex	12150907.	IDA	Component
GO:0001618	virus receptor activity	-	IEA	Function
GO:0001664	G protein-coupled receptor binding	12150907.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005102	signaling receptor binding	24790089.	IPI	Function
GO:0005515	protein binding	15603737.15671022.18975920.21081504.22528486.23349634.24318877.27133716.27137183.27708256.28298427.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005524	ATP binding	23921388.	IDA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	10205060.17167422.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	9553041.10859165.24061851.24790089.	IDA	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005739	mitochondrion	16130169.	TAS	Component
GO:0005783	endoplasmic reticulum	16130169.	TAS	Component
GO:0005813	centrosome	27137183.	IDA	Component
GO:0005814	centriole	24061851.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	21231916.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006402	mRNA catabolic process	10205060.	IDA	Process
GO:0006986	response to unfolded protein	21873635.	IBA	Process
GO:0008180	COP9 signalosome	21873635.	IBA	Component
GO:0008285	negative regulation of cell proliferation	9553041.	IMP	Process
GO:0010628	positive regulation of gene expression	25281747.	IMP	Process
GO:0010941	regulation of cell death	21231916.	IMP	Process
GO:0016234	inclusion body	15603737.	IDA	Component
GO:0016235	aggresome	15885686.	IDA	Component
GO:0016607	nuclear speck	9553041.	IDA	Component
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0016887	ATPase activity	23921388.	IDA	Function
GO:0019899	enzyme binding	23921388.	IPI	Function
GO:0030308	negative regulation of cell growth	9553041.	IMP	Process
GO:0031072	heat shock protein binding	21873635.	IBA	Function
GO:0031072	heat shock protein binding	17182002.21231916.23921388.	IPI	Function
GO:0031396	regulation of protein ubiquitination	16809764.	IDA	Process
GO:0031397	negative regulation of protein ubiquitination	12150907.	IDA	Process
GO:0031625	ubiquitin protein ligase binding	21873635.	IBA	Function
GO:0031625	ubiquitin protein ligase binding	12150907.15603737.	IPI	Function
GO:0031982	vesicle	19190083.	HDA	Component
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0032757	positive regulation of interleukin-8 production	24790089.	IMP	Process
GO:0032991	protein-containing complex	21873635.	IBA	Component
GO:0032991	protein-containing complex	23349634.	IDA	Component
GO:0034599	cellular response to oxidative stress	24252804.	TAS	Process
GO:0034605	cellular response to heat	21873635.	IBA	Process
GO:0034605	cellular response to heat	24061851.	IDA	Process
GO:0034620	cellular response to unfolded protein	21873635.	IBA	Process
GO:0042026	protein refolding	21873635.	IBA	Process
GO:0042026	protein refolding	15603737.21231916.	IDA	Process
GO:0042026	protein refolding	27708256.	IMP	Process
GO:0042623	ATPase activity, coupled	21873635.	IBA	Function
GO:0042623	ATPase activity, coupled	21231916.	IDA	Function
GO:0042623	ATPase activity, coupled	-	TAS	Function
GO:0042826	histone deacetylase binding	16809764.	IPI	Function
GO:0043066	negative regulation of apoptotic process	17167422.	IMP	Process
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0044183	protein binding involved in protein folding	21873635.	IBA	Function
GO:0044183	protein binding involved in protein folding	15603737.	IDA	Function
GO:0045648	positive regulation of erythrocyte differentiation	17167422.	IMP	Process
GO:0046034	ATP metabolic process	23921388.	IDA	Process
GO:0046718	viral entry into host cell	-	IEA	Process
GO:0047485	protein N-terminus binding	9553041.	IPI	Function
GO:0048471	perinuclear region of cytoplasm	10205060.15603737.	IDA	Component
GO:0050821	protein stabilization	24790089.	IMP	Process
GO:0050821	protein stabilization	24252804.	TAS	Process
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:0051082	unfolded protein binding	21231916.	IDA	Function
GO:0051082	unfolded protein binding	12150907.	NAS	Function
GO:0051082	unfolded protein binding	16130169.	TAS	Function
GO:0051085	chaperone cofactor-dependent protein refolding	21873635.	IBA	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	24790089.	IMP	Process
GO:0051787	misfolded protein binding	21873635.	IBA	Function
GO:0055131	C3HC4-type RING finger domain binding	25281747.	IPI	Function
GO:0060548	negative regulation of cell death	12150907.	IDA	Process
GO:0060548	negative regulation of cell death	21231916.	IMP	Process
GO:0070062	extracellular exosome	19199708.20458337.23533145.	HDA	Component
GO:0070370	cellular heat acclimation	21231916.	IMP	Process
GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	24790089.	IMP	Process
GO:0072562	blood microparticle	22516433.	HDA	Component
GO:0090063	positive regulation of microtubule nucleation	27137183.	IMP	Process
GO:0090084	negative regulation of inclusion body assembly	15603737.21231916.	IDA	Process
GO:1900034	regulation of cellular response to heat	-	TAS	Process
GO:1901673	regulation of mitotic spindle assembly	21873635.	IBA	Process
GO:1901673	regulation of mitotic spindle assembly	27137183.	IMP	Process
GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	24790089.	IMP	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component
GO:1990904	ribonucleoprotein complex	17289661.	IDA	Component
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	17167422.	IMP	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.