EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20821256	Actin-sequestering protein, thymosin beta-4, is a novel hypoxia responsive regulator.	Clin Exp Metastasis	2010 Dec	Moon EY	doi: 10.1007/s10585-010-9350-z
17567947	Subcellular distribution of thymosin beta4.	Ann N Y Acad Sci	2007 Sep	Zoubek RE	-
23235961	Immunohistochemical expression of thymosin β4 in ameloblastomas and odontomas.	Histol Histopathol	2013 Jun	Kiyoshima T	doi: 10.14670/HH-28.775
27521796	Thymosin beta 4 silencing suppresses proliferation and invasion of non-small cell lung cancer cells by repressing Notch1 activation.	Acta Biochim Biophys Sin (Shanghai)	2016 Sep	Huang D	doi: 10.1093/abbs/gmw070
28831179	Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck Squamous Cell Carcinoma.	Sci Rep	2017 Aug 22	Chi LH	doi: 10.1038/s41598-017-09539-w.
25218472	Thymosin β4 induces invasion and migration of human colorectal cancer cells through the ILK/AKT/β-catenin signaling pathway.	Biochem Biophys Res Commun	2014 Sep 26	Piao Z	doi: 10.1016/j.bbrc.2014.09.012
18094619	Thymosin Beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation.	Cancer Biol Ther	2008 Mar	Zhang Y	-
20566622	Thymosin beta4 targeting impairs tumorigenic activity of colon cancer stem cells.	FASEB J	2010 Nov	Ricci-Vitiani L	doi: 10.1096/fj.10-159970
22328534	Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration.	Int J Cancer	2012 Nov 1	Ryu YK	doi: 10.1002/ijc.27490
21109953	Thymosin β4 expression correlates with lymph node metastasis through hypoxia inducible factor-α induction in breast cancer.	Oncol Rep	2011 Jan	Yoon SY	-
23045970	Thymosin β4 expression reveals intriguing similarities between fetal and cancer cells.	Ann N Y Acad Sci	2012 Oct	Faa G	doi: 10.1111/j.1749-6632.2012.06679.x.
16949646	Occurrence of thymosin beta4 in human breast cancer cells and in other cell types of the tumor microenvironment.	Hum Pathol	2007 Jan	Larsson LI	-
26556858	MALDI-imaging reveals thymosin beta-4 as an independent prognostic marker for colorectal cancer.	Oncotarget	2015 Dec 22	Gemoll T	doi: 10.18632/oncotarget.6103.
20691219	Thymosin β4 induces the expression of vascular endothelial growth factor (VEGF) in a hypoxia-inducible factor (HIF)-1α-dependent manner.	Biochim Biophys Acta	2010 Nov	Jo JO	doi: 10.1016/j.bbamcr.2010.07.005

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chrX	12976861	3'UTR	novel		0.14
BLCA	chrX	12976914	3'UTR	novel		0.75
CESC	chrX	12976301	Missense_Mutation	NA	D14N	0.24
CESC	chrX	12976850	3'UTR	novel		0.08
CESC	chrX	12976852	3'UTR	novel		0.08
COAD	chrX	12977192	3'Flank	novel		0.42
COAD	chrX	12976939	3'UTR	novel		0.5
COAD	chrX	12976284	Missense_Mutation	rs777121308	A8V	0.09
COAD	chrX	12977062	3'UTR	novel		0.05
DLBC	chrX	12976288	Missense_Mutation	novel	E9D	0.68
DLBC	chrX	12976283	Missense_Mutation	novel	A8P	0.26
DLBC	chrX	12976286	In_Frame_Del	novel	I10_E11del	0.25
DLBC	chrX	12976794	Nonsense_Mutation	NA	Q40*	0.65
DLBC	chrX	12976793	Silent	novel	K39K	0.32
DLBC	chrX	12976245	Splice_Site	novel		0.68
DLBC	chrX	12976275	Missense_Mutation	novel	P5R	0.06
DLBC	chrX	12976362	Splice_Site	novel	X34_splice	0.14
GBM	chrX	12976308	Missense_Mutation	novel	S16L	0.33
HNSC	chrX	12976850	3'UTR	novel		0.08
HNSC	chrX	12976852	3'UTR	novel		0.06
LIHC	chrX	12975141	5'Flank	novel		0.75
LUAD	chrX	12976812	3'UTR	novel		0.22
LUSC	chrX	12976251	5'UTR	novel		0.2
LUSC	chrX	12976873	3'UTR	novel		0.14
LUSC	chrX	12976300	Missense_Mutation	novel	F13L	0.11
LUSC	chrX	12976820	3'UTR	novel		0.69
MESO	chrX	12976828	3'UTR	novel		0.67
OV	chrX	12976905	3'UTR	novel		0.47
OV	chrX	12976870	3'UTR	novel		0.1
OV	chrX	12976258	Missense_Mutation	novel	M1_?5	0.07
SARC	chrX	12976859	3'UTR	novel		0.48
SARC	chrX	12976860	3'UTR	novel		0.48
SKCM	chrX	12976334	Missense_Mutation	novel	E25K	0.25
STAD	chrX	12976330	Silent	NA	T23T	0.41
THCA	chrX	12976850	3'UTR	novel		0.03
THCA	chrX	12976850	3'UTR	novel		0.06
THCA	chrX	12976852	3'UTR	novel		0.04
UCEC	chrX	12976851	3'UTR	novel		0.5
UCEC	chrX	12976964	3'UTR	novel		0.41
UCEC	chrX	12976291	Silent	novel	I10I	0.2
UCEC	chrX	12976865	3'UTR	novel		0.26
UCEC	chrX	12977149	3'Flank	novel		0.88
UCEC	chrX	12977149	3'Flank	novel		0.35
UCEC	chrX	12976964	3'UTR	novel		0.48
UCEC	chrX	12976873	3'UTR	novel		0.42
UCEC	chrX	12976861	3'UTR	novel		0.34
UCEC	chrX	12977149	3'Flank	novel		0.39
UCEC	chrX	12976839	3'UTR	novel		0.27
UCEC	chrX	12977149	3'Flank	novel		0.25
UCEC	chrX	12977125	3'Flank	novel		0.15
UCEC	chrX	12976938	3'UTR	novel		0.2
UCEC	chrX	12976873	3'UTR	rs17008883		0.37
UCEC	chrX	12976906	3'UTR	novel		0.37
UCEC	chrX	12976291	Silent	novel	I10I	0.05
UCEC	chrX	12976895	3'UTR	novel		0.41
UCEC	chrX	12976243	Splice_Region	rs773178435		0.33
UCEC	chrX	12976344	Missense_Mutation	novel	P28Q	0.31
UCEC	chrX	12976857	3'UTR	novel		0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	AMP	0.0909	0.13718
SARC	AMP	0.2607	0.19108
THCA	DEL	0.002	0.21991

Survival Analysis

Cancer	P-value	Q-value
THYM	0.024	Kaplan-Meier Survival Analysis
KIRC	0.0077	Kaplan-Meier Survival Analysis
STAD	0.016	Kaplan-Meier Survival Analysis
HNSC	0.026	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
ESCA	0.0086	Kaplan-Meier Survival Analysis
COAD	0.00042	Kaplan-Meier Survival Analysis
PAAD	0.034	Kaplan-Meier Survival Analysis
PCPG	0.035	Kaplan-Meier Survival Analysis
UCEC	0.0014	Kaplan-Meier Survival Analysis
LIHC	0.0066	Kaplan-Meier Survival Analysis
LUAD	0.00081	Kaplan-Meier Survival Analysis
UVM	0.0036	Kaplan-Meier Survival Analysis
OV	0.0098	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000205542 (Gene tree)
Gene ID: 7114
Gene Symbol: TMSB4X
Alias: TB4X|TMSB4
Full Name: thymosin beta 4 X-linked
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 2,121 bases
Position: chrX:12,975,107-12,977,227
Accession: 11881
RBP type: non-canonical RBP
Summary: This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000451311	TMSB4X-204	628	-	ENSP00000414376	44 (aa)	-	P62328
ENST00000380633	TMSB4X-201	495	-	ENSP00000370007	44 (aa)	-	P62328
ENST00000380635	TMSB4X-202	767	-	ENSP00000370009	44 (aa)	-	P62328
ENST00000380636	TMSB4X-203	1702	-	ENSP00000370010	44 (aa)	-	P62328

Gene Model

Click here to download ENSG00000205542's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04810	Regulation of actin cytoskeleton	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000205542's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000205542	TMSB4X	100	100.000	ENSMUSG00000049775	Tmsb4x	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002576	platelet degranulation	-	TAS	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003785	actin monomer binding	21873635.	IBA	Function
GO:0003785	actin monomer binding	1447300.1999398.	IDA	Function
GO:0005515	protein binding	17967441.20706999.	IPI	Function
GO:0005576	extracellular region	27068509.	HDA	Component
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21343177.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	21343177.	IDA	Component
GO:0005829	cytosol	1447300.	IDA	Component
GO:0005856	cytoskeleton	-	IEA	Component
GO:0007015	actin filament organization	-	IEA	Process
GO:0007253	cytoplasmic sequestering of NF-kappaB	21343177.	IMP	Process
GO:0019899	enzyme binding	21106936.	IPI	Function
GO:0030334	regulation of cell migration	21873635.	IBA	Process
GO:0031093	platelet alpha granule lumen	-	TAS	Component
GO:0032088	negative regulation of NF-kappaB transcription factor activity	21343177.	IMP	Process
GO:0033209	tumor necrosis factor-mediated signaling pathway	21343177.	IMP	Process
GO:0042989	sequestering of actin monomers	21873635.	IBA	Process
GO:0042989	sequestering of actin monomers	1447300.1999398.	IDA	Process
GO:0043536	positive regulation of blood vessel endothelial cell migration	21106936.	IDA	Process
GO:0043536	positive regulation of blood vessel endothelial cell migration	21106936.	IGI	Process
GO:0050727	regulation of inflammatory response	21343177.	IMP	Process
GO:1901222	regulation of NIK/NF-kappaB signaling	21343177.	IGI	Process
GO:1901223	negative regulation of NIK/NF-kappaB signaling	21343177.	IMP	Process
GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	21343177.	IDA	Process
GO:1905273	positive regulation of proton-transporting ATP synthase activity, rotational mechanism	21106936.	IDA	Process
GO:2000483	negative regulation of interleukin-8 secretion	21343177.	IDA	Process
GO:2001028	positive regulation of endothelial cell chemotaxis	21106936.	IDA	Process
GO:2001171	positive regulation of ATP biosynthetic process	21106936.	IDA	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.