EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr3	45735347	Missense_Mutation	novel	R405C	0.29
BLCA	chr3	45743646	Missense_Mutation	novel	V581F	0.69
BLCA	chr3	45732132	Missense_Mutation	NA	E361Q	0.3
BLCA	chr3	45738860	Missense_Mutation	novel	W519L	0.08
BLCA	chr3	45738861	Missense_Mutation	novel	W519C	0.08
BLCA	chr3	45737791	Silent	novel	N443N	0.95
BRCA	chr3	45705139	Missense_Mutation	NA	K45N	0.29
BRCA	chr3	45735208	Intron	novel		0.51
CESC	chr3	45735087	Intron	novel		0.43
CESC	chr3	45709551	Silent	NA	D129D	0.24
CESC	chr3	45735068	Intron	novel		0.44
CESC	chr3	45745060	3'UTR	novel		0.58
COAD	chr3	45735207	Intron	novel		0.33
COAD	chr3	45732084	Frame_Shift_Del	novel	*N346Ifs2**	0.35
COAD	chr3	45689308	5'UTR	novel		0.35
COAD	chr3	45743631	Missense_Mutation	novel	D576N	0.36
COAD	chr3	45706793	Silent	novel	I73I	0.07
COAD	chr3	45738872	Missense_Mutation	NA	A523V	0.37
COAD	chr3	45743558	Silent	NA	A551A	0.3
ESCA	chr3	45735348	Missense_Mutation	rs745878798	R405H	0.25
GBM	chr3	45743689	3'UTR	rs754712614		0.45
GBM	chr3	45735170	Intron	novel		0.09
GBM	chr3	45738634	Missense_Mutation	novel	R480Q	0.33
GBM	chr3	45743752	3'UTR	novel		0.15
HNSC	chr3	45735283	Silent	rs138504596	G383G	0.23
HNSC	chr3	45735304	Missense_Mutation	novel	M390I	0.26
HNSC	chr3	45743594	Frame_Shift_Ins	novel	*I566Yfs76**	0.25
KIRC	chr3	45743843	3'UTR	novel		0.25
KIRP	chr3	45738781	Missense_Mutation	NA	D493N	0.56
KIRP	chr3	45732140	Missense_Mutation	NA	Q363H	0.47
LGG	chr3	45709550	Missense_Mutation	novel	D129G	0.19
LGG	chr3	45703476	Missense_Mutation	rs745558204	D24G	0.25
LIHC	chr3	45713195	Missense_Mutation	NA	E181V	0.39
LIHC	chr3	45706873	Missense_Mutation	NA	Y100C	0.28
LIHC	chr3	45735223	Intron	novel		0.3
LIHC	chr3	45689408	5'UTR	novel		0.46
LIHC	chr3	45709627	Missense_Mutation	novel	E155Q	0.21
LUAD	chr3	45735365	Nonsense_Mutation	novel	Q411*	0.06
LUSC	chr3	45739615	Missense_Mutation	NA	S533L	0.12
LUSC	chr3	45722916	Silent	novel	K271K	0.14
LUSC	chr3	45732057	Missense_Mutation	novel	I336V	0.5
LUSC	chr3	45743848	3'UTR	novel		0.75
OV	chr3	45738799	Missense_Mutation	novel	L499V	0.09
OV	chr3	45705207	Nonsense_Mutation	novel	*G69Sfs6**	0.13
PAAD	chr3	45709623	Silent	novel	F153F	0.09
PCPG	chr3	45706873	Missense_Mutation	NA	Y100C	0.39
PRAD	chr3	45703515	Missense_Mutation	rs761208104	S37Y	0.35
PRAD	chr3	45705189	Missense_Mutation	novel	G62D	0.06
PRAD	chr3	45719531	Silent	NA	G203G	0.08
PRAD	chr3	45705190	Silent	novel	G62G	0.33
READ	chr3	45705146	Missense_Mutation	novel	V48F	0.04
READ	chr3	45709636	Missense_Mutation	novel	L158I	0.32
READ	chr3	45743630	Silent	rs376313343	V575V	0.42
SKCM	chr3	45735334	Silent	novel	Q400Q	0.16
SKCM	chr3	45732102	Nonsense_Mutation	NA	R351*	0.27
SKCM	chr3	45735359	Nonsense_Mutation	NA	Q409*	0.21
SKCM	chr3	45743753	3'UTR	novel		0.44
SKCM	chr3	45743754	3'UTR	novel		0.41
SKCM	chr3	45722009	Missense_Mutation	rs780924690	S230L	0.14
SKCM	chr3	45738656	Silent	rs371656902	S487S	0.39
SKCM	chr3	45706880	Silent	NA	K102K	0.54
STAD	chr3	45735284	Missense_Mutation	rs377734878	V384M	0.33
STAD	chr3	45738656	Silent	rs371656902	S487S	0.15
STAD	chr3	45743556	Missense_Mutation	NA	A551T	0.24
STAD	chr3	45743688	3'UTR	rs200921839		0.09
STAD	chr3	45703508	Missense_Mutation	NA	R35G	0.35
STAD	chr3	45743738	3'UTR	novel		0.4
STAD	chr3	45703484	Missense_Mutation	rs188211739	A27T	0.07
STAD	chr3	45735229	Splice_Region	novel		0.09
STAD	chr3	45738635	In_Frame_Ins	novel	Y482dup	0.12
STAD	chr3	45743568	Missense_Mutation	novel	F555L	0.06
STAD	chr3	45743595	Frame_Shift_Del	NA	*F565Lfs22**	0.3
STAD	chr3	45705136	Splice_Region	NA	V44V	0.35
THCA	chr3	45743587	Missense_Mutation	novel	I561T	0.16
UCEC	chr3	45703492	Silent	rs776446200	D29D	0.21
UCEC	chr3	45719586	Missense_Mutation	rs200252063	R222C	0.18
UCEC	chr3	45719587	Missense_Mutation	novel	R222H	0.37
UCEC	chr3	45738634	Missense_Mutation	novel	R480Q	0.14
UCEC	chr3	45709576	Missense_Mutation	novel	D138Y	0.07
UCEC	chr3	45709523	Missense_Mutation	rs769223692	A120V	0.47
UCEC	chr3	45744490	3'UTR	novel		0.48
UCEC	chr3	45743791	3'UTR	novel		0.46
UCEC	chr3	45743781	3'UTR	novel		0.17
UCEC	chr3	45705196	Silent	novel	I64I	0.19
UCEC	chr3	45744391	3'UTR	novel		0.55
UCEC	chr3	45735137	Intron	novel		0.38
UCEC	chr3	45722875	Nonsense_Mutation	novel	G258*	0.23
UCEC	chr3	45709583	Missense_Mutation	novel	T140I	0.42
UCEC	chr3	45744514	3'UTR	rs373072063		0.19
UCEC	chr3	45706797	Missense_Mutation	novel	I75V	0.3
UCEC	chr3	45743761	3'UTR	novel		0.41
UCEC	chr3	45744727	3'UTR	novel		0.5
UCEC	chr3	45709522	Missense_Mutation	novel	A120S	0.35
UCEC	chr3	45735222	Intron	novel		0.38
UCEC	chr3	45709591	Silent	novel	L143L	0.28
UCEC	chr3	45745266	3'UTR	novel		0.27
UCEC	chr3	45744812	3'UTR	novel		0.34
UCEC	chr3	45722046	Missense_Mutation	novel	Q242H	0.42
UCEC	chr3	45744514	3'UTR	rs373072063		0.17
UCEC	chr3	45732102	Nonsense_Mutation	NA	R351*	0.47
UCEC	chr3	45743624	Missense_Mutation	novel	D573E	0.38
UCEC	chr3	45705192	Missense_Mutation	novel	T63I	0.33
UCEC	chr3	45735132	Intron	novel		0.33
UCEC	chr3	45703466	Missense_Mutation	novel	E21K	0.21
UCEC	chr3	45722009	Missense_Mutation	rs780924690	S230L	0.15
UCEC	chr3	45737643	Missense_Mutation	novel	Y434D	0.21
UCEC	chr3	45744709	3'UTR	novel		0.09
UCEC	chr3	45735258	Missense_Mutation	novel	G375D	0.12
UCEC	chr3	45709539	Silent	NA	V125V	0.37
UCEC	chr3	45732102	Nonsense_Mutation	NA	R351*	0.42
UCEC	chr3	45738785	Missense_Mutation	novel	S494Y	0.18
UCEC	chr3	45738807	Silent	novel	N501N	0.13
UCEC	chr3	45743607	Missense_Mutation	novel	L568I	0.36
UCEC	chr3	45743771	3'UTR	novel		0.27
UCEC	chr3	45744417	3'UTR	novel		0.31
UCS	chr3	45722009	Missense_Mutation	rs780924690	S230L	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.8056	0.02241
DLBC	DEL	0.125	0.016959
GBM	DEL	0.078	0.056565
LGG	DEL	0.078	0.00089193
LUAD	DEL	0.3353	0.0021265
PAAD	DEL	0.1793	0.030662
SARC	DEL	0.1907	0.0034746
SKCM	DEL	0.1635	0.13887
TGCT	DEL	0.2	0.08422
THYM	DEL	0.0894	0.037527

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.014	Kaplan-Meier Survival Analysis
SARC	0.046	Kaplan-Meier Survival Analysis
SKCM	0.002	Kaplan-Meier Survival Analysis
PRAD	0.0077	Kaplan-Meier Survival Analysis
KIRP	0.026	Kaplan-Meier Survival Analysis
COAD	0.0071	Kaplan-Meier Survival Analysis
BLCA	0.015	Kaplan-Meier Survival Analysis
READ	0.013	Kaplan-Meier Survival Analysis
LAML	0.01	Kaplan-Meier Survival Analysis
KICH	0.032	Kaplan-Meier Survival Analysis
GBM	0.031	Kaplan-Meier Survival Analysis
LIHC	0.018	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0014	Kaplan-Meier Survival Analysis
OV	0.015	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000211456 (Gene tree)
Gene ID: 22908
Gene Symbol: SACM1L
Alias: SAC1|KIAA0851
Full Name: SAC1 like phosphatidylinositide phosphatase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 56,369 bases
Position: chr3:45,689,056-45,745,424
Accession: 17059
RBP type: non-canonical RBP
Summary: This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame, downstream translation termination codon via a stop codon readthrough mechanism.[provided by RefSeq, Dec 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000418611	SACM1L-202	2164	-	ENSP00000396387	484 (aa)	-	E9PGZ4
ENST00000478586	SACM1L-214	534	-	-	- (aa)	-	-
ENST00000463347	SACM1L-209	854	-	-	- (aa)	-	-
ENST00000438671	SACM1L-204	542	-	ENSP00000411966	112 (aa)	-	C9J3E3
ENST00000389061	SACM1L-201	3723	XM_011533500	ENSP00000373713	587 (aa)	XP_011531802	Q9NTJ5
ENST00000463237	SACM1L-208	962	-	-	- (aa)	-	-
ENST00000485311	SACM1L-215	591	-	-	- (aa)	-	-
ENST00000445499	SACM1L-206	583	-	-	- (aa)	-	-
ENST00000464102	SACM1L-211	3043	-	-	- (aa)	-	-
ENST00000441228	SACM1L-205	2013	-	ENSP00000406263	71 (aa)	-	F8WCQ2
ENST00000471207	SACM1L-213	534	-	-	- (aa)	-	-
ENST00000463659	SACM1L-210	950	-	-	- (aa)	-	-
ENST00000455997	SACM1L-207	4661	-	ENSP00000389975	287 (aa)	-	F8WDN7
ENST00000464524	SACM1L-212	571	-	-	- (aa)	-	-
ENST00000433336	SACM1L-203	678	-	ENSP00000412883	187 (aa)	-	C9JV50

Gene Model

Click here to download ENSG00000211456's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00562	Inositol phosphate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04070	Phosphatidylinositol signaling system	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000211456	Lip	1E-7	27560520
ENSG00000211456	Antidepressive Agents	5E-7	22041458
ENSG00000211456	Bupropion	5E-7	22041458
ENSG00000211456	Sexual Dysfunctions, Psychological	5E-7	22041458

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000211456	rs71288019	3	45710501	C	Lip morphology	27560520	[0.32-0.71] unit increase	0.5144	EFO_0007845
ENSG00000211456	rs2742417	3	45689959	T	Response to anti-depressant treatment in major depressive disorder	22041458			EFO_0006322\|EFO_0006326\|GO_0036276

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000211456's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000211456	SACM1L	96	47.027	YKL212W	SAC1	92	35.959	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	TAS	Component
GO:0004438	phosphatidylinositol-3-phosphatase activity	-	TAS	Function
GO:0005515	protein binding	14527956.	IPI	Function
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	-	ISS	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0006661	phosphatidylinositol biosynthetic process	-	TAS	Process
GO:0016791	phosphatase activity	-	ISS	Function
GO:0030176	integral component of endoplasmic reticulum membrane	-	IEA	Component
GO:0032281	AMPA glutamate receptor complex	-	IEA	Component
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	-	IEA	Function
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	-	TAS	Function
GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity	21873635.	IBA	Function
GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity	24209621.	IDA	Function
GO:0046856	phosphatidylinositol dephosphorylation	21873635.	IBA	Process
GO:0046856	phosphatidylinositol dephosphorylation	24209621.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.