EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19049977	Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.	J Biol Chem	2009 Feb 6	Arzoine L	doi: 10.1074/jbc.M803614200
27080741	Reducing VDAC1 expression induces a non-apoptotic role for pro-apoptotic proteins in cancer cell differentiation.	Biochim Biophys Acta	2016 Aug	Arif T	doi: 10.1016/j.bbabio.2016.04.005
25341036	Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation.	Cell Death Dis	2014 Oct 23	Huang H	doi: 10.1038/cddis.2014.419.
26716410	Clinical implication of voltage-dependent anion channel 1 in uterine cervical cancer and its action on cervical cancer cells.	Oncotarget	2016 Jan 26	Wu CH	doi: 10.18632/oncotarget.6704.
26646027	Mitochondrial Proteomics Approach Reveals Voltage-Dependent Anion Channel 1 (VDAC1) as a Potential Biomarker of Gastric Cancer.	Cell Physiol Biochem	2015	Gao W	doi: 10.1159/000438588
22589539	Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein.	J Biol Chem	2012 Jun 29	Arbel N	doi: 10.1074/jbc.M112.345918
19094960	Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase.	Biochim Biophys Acta	2009 May	Shoshan-Barmatz V	doi: 10.1016/j.bbabio.2008.11.009
27419626	Proteomics-based identification of VDAC1 as a tumor promoter in cervical carcinoma.	Oncotarget	2016 Aug 9	Zhang C	doi: 10.18632/oncotarget.10562.
27304056	Decreased expression of microRNA-320a promotes proliferation and invasion of non-small cell lung cancer cells by increasing VDAC1 expression.	Oncotarget	2016 Aug 2	Zhang G	doi: 10.18632/oncotarget.9943.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr5	133973800	Missense_Mutation	novel	L251V	0.27
BLCA	chr5	133991062	Silent	rs201680896	T70T	0.12
BLCA	chr5	133991135	Missense_Mutation	rs769081892	S46L	0.24
BLCA	chr5	133990867	Missense_Mutation	novel	S104L	0.16
BRCA	chr5	133991073	Missense_Mutation	novel	Y67H	0.12
BRCA	chr5	133992981	Missense_Mutation	novel	G11D	0.06
BRCA	chr5	133975922	Silent	rs542220207	T217T	0.26
BRCA	chr5	133980836	Silent	novel	G148G	0.08
CESC	chr5	133991124	Missense_Mutation	NA	E50Q	0.48
CESC	chr5	133972360	3'UTR	novel		0.5
COAD	chr5	133980797	Missense_Mutation	novel	K161N	0.29
COAD	chr5	133972821	Missense_Mutation	rs774989304	V268I	0.16
COAD	chr5	133991053	Missense_Mutation	NA	E73D	0.15
COAD	chr5	133975974	In_Frame_Ins	novel	K200delinsIPTE	0.05
COAD	chr5	133975920	Missense_Mutation	rs768574647	R218H	0.15
COAD	chr5	133980793	Nonsense_Mutation	NA	R163*	0.4
ESCA	chr5	133991066	Missense_Mutation	novel	L69P	0.4
GBM	chr5	133980735	Missense_Mutation	novel	T182S	0.21
GBM	chr5	133980826	Missense_Mutation	novel	G152C	0.06
GBM	chr5	133991006	Missense_Mutation	novel	D89G	0.08
HNSC	chr5	133991116	Silent	novel	T52T	0.16
LAML	chr5	133991119	Silent	novel	T51T	0.04
LAML	chr5	133972800	Missense_Mutation	novel	L275F	0.14
LIHC	chr5	133991004	Nonsense_Mutation	novel	Q90*	0.46
LIHC	chr5	133980946	Missense_Mutation	novel	A112P	0.16
LIHC	chr5	133975884	Missense_Mutation	novel	D230G	0.12
LUAD	chr5	133972791	Missense_Mutation	rs756691461	G278R	0.48
LUSC	chr5	133980841	Missense_Mutation	NA	E147K	0.31
OV	chr5	133980743	Missense_Mutation	novel	Q179H	0.07
OV	chr5	133975923	Missense_Mutation	novel	T217M	0.53
OV	chr5	133991020	Silent	novel	E84E	0.15
PAAD	chr5	133991058	Missense_Mutation	rs774695024	T72A	0.19
PRAD	chr5	133991063	Missense_Mutation	rs767734111	T70M	0.13
READ	chr5	133972768	3'UTR	novel		0.08
SARC	chr5	133972778	Missense_Mutation	novel	Q282P	0.12
SARC	chr5	133972737	3'UTR	novel		0.39
SKCM	chr5	133980745	Nonsense_Mutation	NA	Q179*	0.25
SKCM	chr5	133980874	Missense_Mutation	novel	P136S	0.23
STAD	chr5	133992348	Silent	NA	G25G	0.29
STAD	chr5	133975922	Silent	rs542220207	T217T	0.43
STAD	chr5	133993000	Missense_Mutation	NA	P5S	0.32
STAD	chr5	133973842	Missense_Mutation	NA	V237M	0.3
STAD	chr5	133975945	Missense_Mutation	NA	W210R	0.04
THCA	chr5	133975921	Missense_Mutation	rs375779223	R218C	0.21
UCEC	chr5	133980886	Missense_Mutation	rs377065269	D132N	0.63
UCEC	chr5	133991040	Missense_Mutation	NA	D78N	0.32
UCEC	chr5	133972334	3'UTR	novel		0.3
UCEC	chr5	133972761	3'UTR	novel		0.33
UCEC	chr5	133972760	3'UTR	novel		0.47
UCEC	chr5	133980919	Nonsense_Mutation	novel	E121*	0.26
UCEC	chr5	133980892	Missense_Mutation	novel	D130N	0.35
UCEC	chr5	133972171	3'UTR	novel		0.38
UCEC	chr5	133971941	3'UTR	novel		0.43
UCEC	chr5	133972685	3'UTR	novel		0.5
UCEC	chr5	133991008	Missense_Mutation	novel	E88D	0.38
UCEC	chr5	133972171	3'UTR	novel		0.5
UCEC	chr5	133992956	Silent	novel	T19T	0.21
UCEC	chr5	133972856	Missense_Mutation	novel	K256T	0.44
UCEC	chr5	133975915	Missense_Mutation	novel	G220R	0.43
UCEC	chr5	133972170	3'UTR	novel		0.36
UCEC	chr5	133972171	3'UTR	novel		0.51
UCEC	chr5	133992346	Missense_Mutation	novel	L26S	0.59
UCEC	chr5	133971930	3'UTR	novel		0.46
UCEC	chr5	133972602	3'UTR	novel		0.36
UCEC	chr5	133975960	Missense_Mutation	novel	A205T	0.28
UCEC	chr5	133972016	3'UTR	novel		0.29
UCEC	chr5	133990857	Splice_Region	novel	T107T	0.43
UCEC	chr5	133975922	Silent	rs542220207	T217T	0.15
UCEC	chr5	133975921	Missense_Mutation	rs375779223	R218C	0.09
UCEC	chr5	133972852	Silent	NA	L257L	0.08
UCEC	chr5	133991062	Silent	rs201680896	T70T	0.24
UCEC	chr5	133991107	Silent	rs556113860	T55T	0.44
UCEC	chr5	133972015	3'UTR	novel		0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0382	0.11554
LAML	DEL	0.089	1.2971e-07
LUAD	DEL	0.3081	7.4776e-05
LUSC	DEL	0.6427	0.002071
MESO	DEL	0.1494	0.20184
PRAD	AMP	0.0305	0.16448
STAD	DEL	0.2744	2.8835e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0088	Kaplan-Meier Survival Analysis
SARC	0.026	Kaplan-Meier Survival Analysis
MESO	0.035	Kaplan-Meier Survival Analysis
HNSC	0.00046	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
BRCA	0.0032	Kaplan-Meier Survival Analysis
ESCA	0.036	Kaplan-Meier Survival Analysis
COAD	0.026	Kaplan-Meier Survival Analysis
PAAD	0.015	Kaplan-Meier Survival Analysis
CESC	0.031	Kaplan-Meier Survival Analysis
GBM	0.001	Kaplan-Meier Survival Analysis
LIHC	0.00018	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000213585 (Gene tree)
Gene ID: 7416
Gene Symbol: VDAC1
Alias: MGC111064|PORIN
Full Name: voltage dependent anion channel 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 33,515 bases
Position: chr5:133,971,875-134,005,389
Accession: 12669
RBP type: non-canonical RBP
Summary: This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30209975	Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.	Autophagy	2019 Jan	Yau WW	doi: 10.1080/15548627.2018.1511263

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000425992	VDAC1-204	703	-	ENSP00000390129	183 (aa)	-	C9JI87
ENST00000466080	VDAC1-205	831	-	-	- (aa)	-	-
ENST00000395044	VDAC1-202	1807	XM_017009821	ENSP00000378484	283 (aa)	XP_016865310	P21796
ENST00000265333	VDAC1-201	1953	XM_005272075	ENSP00000265333	283 (aa)	XP_005272132	P21796
ENST00000395047	VDAC1-203	1873	-	ENSP00000378487	283 (aa)	-	P21796
ENST00000489906	VDAC1-206	694	-	-	- (aa)	-	-
ENST00000492324	VDAC1-207	635	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000213585's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04020	Calcium signaling pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04217	Necroptosis	KEGG
hsa04218	Cellular senescence	KEGG
hsa04621	NOD-like receptor signaling pathway	KEGG
hsa04979	Cholesterol metabolism	KEGG
hsa05012	Parkinson disease	KEGG
hsa05016	Huntington disease	KEGG
hsa05164	Influenza A	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000213585	Platelet Function Tests	1.8990500E-005	-
ENSG00000213585	Multiple Sclerosis	6E-7	21833088
ENSG00000213585	Lupus Erythematosus, Systemic	4E-10	27399966
ENSG00000213585	Lupus Erythematosus, Systemic	7E-10	26502338
ENSG00000213585	Lupus Erythematosus, Systemic	4E-16	26502338

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000213585's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000213585	VDAC1	98	40.659	WBGene00019900	vdac-1	98	40.357	Caenorhabditis_elegans
ENSG00000213585	VDAC1	100	74.558	ENSG00000165637	VDAC2	96	74.908	Homo_sapiens
ENSG00000213585	VDAC1	100	98.587	ENSMUSG00000020402	Vdac1	100	98.587	Mus_musculus
ENSG00000213585	VDAC1	100	74.205	ENSMUSG00000021771	Vdac2	100	74.205	Mus_musculus
ENSG00000213585	VDAC1	100	67.491	ENSMUSG00000008892	Vdac3	100	67.491	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001662	behavioral fear response	-	IEA	Process
GO:0005515	protein binding	9843949.21370995.23055042.25296756.25556234.26387735.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005741	mitochondrial outer membrane	21873635.	IBA	Component
GO:0005741	mitochondrial outer membrane	17008324.25244949.	IDA	Component
GO:0005741	mitochondrial outer membrane	-	TAS	Component
GO:0005757	mitochondrial permeability transition pore complex	26387735.	IDA	Component
GO:0005886	plasma membrane	25296756.	IDA	Component
GO:0006090	pyruvate metabolic process	-	TAS	Process
GO:0006820	anion transport	8420959.	IDA	Process
GO:0006851	mitochondrial calcium ion transmembrane transport	-	IEA	Process
GO:0006915	apoptotic process	25296756.	IDA	Process
GO:0006915	apoptotic process	10365962.	TAS	Process
GO:0007270	neuron-neuron synaptic transmission	-	IEA	Process
GO:0007612	learning	-	IEA	Process
GO:0008021	synaptic vesicle	-	IEA	Component
GO:0008308	voltage-gated anion channel activity	21873635.	IBA	Function
GO:0008308	voltage-gated anion channel activity	8420959.	IDA	Function
GO:0008308	voltage-gated anion channel activity	-	ISS	Function
GO:0008308	voltage-gated anion channel activity	-	TAS	Function
GO:0015288	porin activity	-	IEA	Function
GO:0015698	inorganic anion transport	-	IEA	Process
GO:0016020	membrane	-	ISS	Component
GO:0016032	viral process	-	IEA	Process
GO:0016236	macroautophagy	-	TAS	Process
GO:0019901	protein kinase binding	21370995.	IPI	Function
GO:0030855	epithelial cell differentiation	21492153.	IEP	Process
GO:0042645	mitochondrial nucleoid	18063578.	IDA	Component
GO:0044325	ion channel binding	25296756.	IPI	Function
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0045121	membrane raft	-	IEA	Component
GO:0046930	pore complex	9843949.	TAS	Component
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0098656	anion transmembrane transport	-	IEA	Process
GO:1903146	regulation of autophagy of mitochondrion	20098416.	NAS	Process
GO:2000378	negative regulation of reactive oxygen species metabolic process	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.