EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21528671	Basic fibroblast growth factor affects the expression of angiogenin and cell proliferation in A375 human melanoma cells.	Tumori	2011 Jan-Feb	Zhao J	-
24561529	Angiogenin promotes tumoral growth and angiogenesis by regulating matrix metallopeptidase-2 expression via the ERK1/2 pathway.	Oncogene	2015 Feb 12	Miyake M	doi: 10.1038/onc.2014.2
25604905	Angiogenin secretion from hepatoma cells activates hepatic stellate cells to amplify a self-sustained cycle promoting liver cancer.	Sci Rep	2015 Jan 21	B??rcena C	doi: 10.1038/srep07916.
25552400	Pharmacokinetics of neamine in rats and anti-cervical cancer activity in vitro and in vivo.	Cancer Chemother Pharmacol	2015 Mar	Liu Y	doi: 10.1007/s00280-014-2658-7
26272182	Tumor cell-secreted angiogenin induces angiogenic activity of endothelial cells by suppressing miR-542-3p.	Cancer Lett	2015 Nov 1	He T	doi: 10.1016/j.canlet.2015.07.036
23851444	Angiogenin mediates androgen-stimulated prostate cancer growth and enables castration resistance.	Mol Cancer Res	2013 Oct	Li S	doi: 10.1158/1541-7786.MCR-13-0072
21778318	Prognostic significance of the angiogenic factors angiogenin, endoglin and endostatin in cervical cancer.	Anticancer Res	2011 Aug	Landt S	-
12168899	Distribution of angiogenin and its gene message in colorectal cancer patients and their clinical relevance.	Anticancer Res	2002 Mar-Apr	Shimoyama S	-
23921786	Can serum angiogenin be used to improve the diagnostic performance in prostate cancer screening?	Eur J Cancer Prev	2014 May	Pina F	doi: 10.1097/CEJ.0b013e3283647453.
23977052	Identification of estrogen receptor-related receptor gamma as a direct transcriptional target of angiogenin.	PLoS One	2013 Aug 15	Ang J	doi: 10.1371/journal.pone.0071487
16322296	Elevated expression of angiogenin in prostate cancer and its precursors.	Clin Cancer Res	2005 Dec 1	Katona TM	-
24457100	Angiogenin interacts with the plasminogen activation system at the cell surface of breast cancer cells to regulate plasmin formation and cell migration.	Mol Oncol	2014 May	Dutta S	doi: 10.1016/j.molonc.2013.12.017
24696417	Diagnostic evaluation of urinary angiogenin (ANG) and clusterin (CLU) as biomarker for bladder cancer.	Pathol Oncol Res	2014 Oct	Shabayek MI	doi: 10.1007/s12253-014-9765-y
25564356	Downregulation of angiogenin inhibits the growth and induces apoptosis in human bladder cancer cells through regulating AKT/mTOR signaling pathway.	J Mol Histol	2015 Apr	Shu J	doi: 10.1007/s10735-014-9608-x
29100074	Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin.	Cell	2017 Nov 2	Yu W	doi: 10.1016/j.cell.2017.10.005.
29105754	Interaction between human angiogenin and the p53 TAD2 domain and its implication for inhibitor discovery.	FEBS Lett	2017 Dec	Yeo KJ	doi: 10.1002/1873-3468.12899
29606349	Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer.	Cancer Cell	2018 Apr 9	Wang YN	doi: 10.1016/j.ccell.2018.02.012
29763380	Angiogenin and the MMP9-TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer.	FASEB J	2018 Oct	Bruno A	doi: 10.1096/fj.201701103R

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
CESC	chr14	20693829	Missense_Mutation	novel	H89D	0.1	RnaseA
COAD	chr14	20693920	Missense_Mutation	rs141398857	R119Q	0.44	RnaseA
COAD	chr14	20694062	3'UTR	novel		0.43
COAD	chr14	20694014	3'UTR	rs537748610		0.28
HNSC	chr14	20693930	Silent	rs369214577	A122A	0.21
LGG	chr14	20693733	Missense_Mutation	rs749308574	R57W	0.22	RnaseA
LGG	chr14	20694013	3'UTR	novel		0.29
LIHC	chr14	20693887	Missense_Mutation	novel	H108L	0.26	RnaseA
LUSC	chr14	20694005	Silent	rs759928848	P147P	0.13
LUSC	chr14	20693866	Missense_Mutation	novel	Q101L	0.22	RnaseA
PRAD	chr14	20694039	3'UTR	novel		0.35
READ	chr14	20694159	3'UTR	novel		0.37
SARC	chr14	20693950	Missense_Mutation	novel	V129D	0.29	RnaseA
SKCM	chr14	20693976	Missense_Mutation	NA	H138Y	0.24	RnaseA
SKCM	chr14	20694003	Missense_Mutation	NA	P147S	0.07
SKCM	chr14	20693896	Missense_Mutation	NA	S111F	0.09	RnaseA
SKCM	chr14	20694059	3'UTR	rs773360024		0.27
SKCM	chr14	20693934	Missense_Mutation	NA	F124L	0.15	RnaseA
SKCM	chr14	20694059	3'UTR	rs773360024		0.55
SKCM	chr14	20694105	3'UTR	novel		0.56
STAD	chr14	20693942	Silent	rs778252755	N126N	0.45
TGCT	chr14	20694005	Silent	rs759928848	P147P	0.07
UCEC	chr14	20694169	3'UTR	novel		0.33
UCEC	chr14	20693697	Missense_Mutation	novel	R45W	0.4	RnaseA
UCEC	chr14	20693833	Missense_Mutation	novel	R90I	0.05	RnaseA
UCEC	chr14	20693788	Missense_Mutation	rs146485834	R75H	0.13	RnaseA
UCEC	chr14	20693963	Silent	NA	N133N	0.25

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.2667	0.056464
ACC	DEL	0.1444	0.19769
CHOL	DEL	0.3611	0.00040262
HNSC	DEL	0.1073	0.0025503
KIRP	DEL	0.1632	0.085174
LUSC	DEL	0.2595	0.0082553
PAAD	DEL	0.0924	0.11332
READ	DEL	0.3697	0.0043084

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0044	Kaplan-Meier Survival Analysis
KIRC	0.0052	Kaplan-Meier Survival Analysis
STAD	0.049	Kaplan-Meier Survival Analysis
SARC	0.004	Kaplan-Meier Survival Analysis
MESO	0.00078	Kaplan-Meier Survival Analysis
ACC	0.00013	Kaplan-Meier Survival Analysis
SKCM	0.011	Kaplan-Meier Survival Analysis
ESCA	0.0093	Kaplan-Meier Survival Analysis
KICH	0.023	Kaplan-Meier Survival Analysis
UCEC	0.00058	Kaplan-Meier Survival Analysis
GBM	0.027	Kaplan-Meier Survival Analysis
LIHC	0.00033	Kaplan-Meier Survival Analysis
UVM	0.0003	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000214274 (Gene tree)
Gene ID: 283
Gene Symbol: ANG
Alias: RNASE5|RAA1
Full Name: angiogenin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 14,795 bases
Position: chr14:20,684,177-20,698,971
Accession: 483
RBP type: canonical RBP
Summary: The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000336762	RnaseA	PF00074.20	1e-34	1	1
ENSP00000381077	RnaseA	PF00074.20	1e-34	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12515546	Identification and characterization of an angiogenin-binding DNA sequence that stimulates luciferase reporter gene expression.	Biochemistry	2003 Jan 14	Xu ZP	-
9305884	Anti-angiogenin activity of the peptides complementary to the receptor-binding site of angiogenin.	J Biol Chem	1997 Sep 26	Gho YS	-
18604453	Mechanisms of action of angiogenin.	Acta Biochim Biophys Sin (Shanghai)	2008 Jul	Gao X	-
24659782	Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop.	J Biol Chem	2014 May 2	Sheng J	doi: 10.1074/jbc.M114.551762
23772376	Crystal structure of human angiogenin with an engineered loop exhibits conformational flexibility at the functional regions of the molecule.	FEBS Open Bio	2012 Dec 26	Thiyagarajan N	doi: 10.1016/j.fob.2012.12.003
8127865	Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity.	Proc Natl Acad Sci U S A	1994 Mar 1	Moroianu J	-
11851402	Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency.	Biochemistry	2002 Feb 26	Leonidas DD	-
11468363	Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography.	Protein Sci	2001 Aug	Leonidas DD	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000336811	ANG-201	1222	-	ENSP00000336762	147 (aa)	-	P03950
ENST00000397990	ANG-202	742	-	ENSP00000381077	147 (aa)	-	P03950
ENST00000554073	ANG-203	251	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000214274's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000214274	Stroke	2.1727993E-004	-
ENSG00000214274	Cryptoxanthins	8.3140000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000214274	rs184297073	14	20690905	T	Blood protein levels	29875488	[1.78-2.44] unit decrease	2.11	EFO_0007937
ENSG00000214274	rs1888562	14	20696377	T	Blood protein levels	29875488	[0.23-0.35] unit decrease	0.29	EFO_0007937
ENSG00000214274	rs17114671	14	20687111	C	Blood protein levels	28240269	[0.69-0.92] unit increase	0.8064	EFO_0008022
ENSG00000214274	rs1888560	14	20696086	T	Blood protein levels	28240269	[0.26-0.43] unit decrease	0.3446	EFO_0008022
ENSG00000214274	rs17114699	14	20690751	T	Blood protein levels	28240269	[0.63-0.88] unit increase	0.7532	EFO_0008022
ENSG00000214274	rs1888560	14	20696086	C	Blood protein levels	30072576	[0.17-0.27] unit increase	0.223	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000214274's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000214274	ANG	82	39.837	ENSG00000258818	RNASE4	83	39.837
ENSG00000214274	ANG	76	32.283	ENSG00000165799	RNASE7	76	32.283
ENSG00000214274	ANG	86	35.507	ENSG00000129538	RNASE1	94	36.522

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000214274	ANG	99	77.241	ENSAMEG00000018660	ANG	87	76.378	Ailuropoda_melanoleuca
ENSG00000214274	ANG	93	63.504	ENSBTAG00000032873	-	72	61.983	Bos_taurus
ENSG00000214274	ANG	97	66.434	ENSBTAG00000019612	RNASE4	97	65.972	Bos_taurus
ENSG00000214274	ANG	98	55.556	ENSBTAG00000046668	ANG2	97	55.556	Bos_taurus
ENSG00000214274	ANG	97	64.336	ENSCHIG00000010811	-	97	64.336	Capra_hircus
ENSG00000214274	ANG	97	66.434	ENSCHIG00000010308	-	97	65.972	Capra_hircus
ENSG00000214274	ANG	78	48.462	ENSCPBG00000000657	-	82	48.462	Chrysemys_picta_bellii
ENSG00000214274	ANG	85	42.063	ENSCPBG00000009437	-	85	41.600	Chrysemys_picta_bellii
ENSG00000214274	ANG	98	67.361	ENSCGRG00001006777	-	58	68.000	Cricetulus_griseus_chok1gshd
ENSG00000214274	ANG	98	67.361	ENSCGRG00000016447	-	79	68.000	Cricetulus_griseus_crigri
ENSG00000214274	ANG	99	75.172	ENSEASG00005002967	ANG	87	74.803	Equus_asinus_asinus
ENSG00000214274	ANG	99	75.172	ENSECAG00000035254	ANG	87	74.803	Equus_caballus
ENSG00000214274	ANG	99	78.621	ENSFCAG00000041462	ANG	99	78.621	Felis_catus
ENSG00000214274	ANG	79	48.855	ENSGAGG00000006587	-	64	48.855	Gopherus_agassizii
ENSG00000214274	ANG	92	42.647	ENSGAGG00000019734	-	85	41.600	Gopherus_agassizii
ENSG00000214274	ANG	100	99.320	ENSGGOG00000044112	ANG	100	99.320	Gorilla_gorilla
ENSG00000214274	ANG	98	67.361	ENSMAUG00000010475	-	86	68.000	Mesocricetus_auratus
ENSG00000214274	ANG	99	67.808	ENSMOCG00000000621	-	88	68.750	Microtus_ochrogaster
ENSG00000214274	ANG	87	63.077	ENSMODG00000006972	ANG	81	63.077	Monodelphis_domestica
ENSG00000214274	ANG	98	74.306	ENSMUSG00000072115	Ang	86	78.400	Mus_musculus
ENSG00000214274	ANG	97	66.434	ENSMUSG00000047894	Ang2	85	68.548	Mus_musculus
ENSG00000214274	ANG	84	66.129	ENSMUSG00000060615	Ang4	85	66.129	Mus_musculus
ENSG00000214274	ANG	97	65.035	ENSMUSG00000053961	Ang5	85	66.935	Mus_musculus
ENSG00000214274	ANG	97	57.241	ENSMUSG00000072598	Ang6	98	57.241	Mus_musculus
ENSG00000214274	ANG	98	70.833	MGP_PahariEiJ_G0030242	-	86	72.800	Mus_pahari
ENSG00000214274	ANG	98	70.833	MGP_PahariEiJ_G0030240	-	86	72.800	Mus_pahari
ENSG00000214274	ANG	98	73.611	MGP_SPRETEiJ_G0020109	Ang	86	77.600	Mus_spretus
ENSG00000214274	ANG	98	65.278	MGP_SPRETEiJ_G0021593	-	86	67.200	Mus_spretus
ENSG00000214274	ANG	98	65.278	MGP_SPRETEiJ_G0021592	-	86	67.200	Mus_spretus
ENSG00000214274	ANG	99	68.966	ENSMLUG00000024437	-	87	69.291	Myotis_lucifugus
ENSG00000214274	ANG	99	68.276	ENSMLUG00000025641	-	87	68.504	Myotis_lucifugus
ENSG00000214274	ANG	87	68.750	ENSMLUG00000029656	-	87	68.504	Myotis_lucifugus
ENSG00000214274	ANG	98	68.750	ENSMLUG00000029597	-	88	69.048	Myotis_lucifugus
ENSG00000214274	ANG	98	65.278	ENSMLUG00000027892	-	86	65.873	Myotis_lucifugus
ENSG00000214274	ANG	98	68.750	ENSMLUG00000028700	-	88	69.048	Myotis_lucifugus
ENSG00000214274	ANG	86	71.654	ENSMLUG00000027018	-	85	71.429	Myotis_lucifugus
ENSG00000214274	ANG	98	78.472	ENSNGAG00000018469	-	86	80.952	Nannospalax_galili
ENSG00000214274	ANG	95	61.538	ENSMEUG00000000681	ANG	83	62.712	Notamacropus_eugenii
ENSG00000214274	ANG	98	63.194	ENSOGAG00000027209	ANG	86	61.111	Otolemur_garnettii
ENSG00000214274	ANG	98	54.861	ENSOARG00000013005	-	97	54.861	Ovis_aries
ENSG00000214274	ANG	97	63.636	ENSOARG00000012562	-	97	63.636	Ovis_aries
ENSG00000214274	ANG	100	98.639	ENSPPAG00000032810	ANG	100	98.639	Pan_paniscus
ENSG00000214274	ANG	99	78.621	ENSPPRG00000020077	ANG	99	78.621	Panthera_pardus
ENSG00000214274	ANG	99	78.621	ENSPTIG00000004149	ANG	99	78.621	Panthera_tigris_altaica
ENSG00000214274	ANG	100	99.320	ENSPTRG00000043768	ANG	100	99.320	Pan_troglodytes
ENSG00000214274	ANG	94	41.892	ENSPKIG00000000354	-	66	44.800	Paramormyrops_kingsleyae
ENSG00000214274	ANG	80	43.939	ENSPSIG00000000732	ANG	82	43.939	Pelodiscus_sinensis
ENSG00000214274	ANG	98	69.444	ENSPEMG00000013152	-	86	69.048	Peromyscus_maniculatus_bairdii
ENSG00000214274	ANG	97	54.545	ENSPCAG00000006037	ANG	84	52.000	Procavia_capensis
ENSG00000214274	ANG	99	78.621	ENSPCOG00000013248	ANG	99	78.621	Propithecus_coquereli
ENSG00000214274	ANG	99	65.517	ENSPVAG00000013562	ANG	99	65.517	Pteropus_vampyrus
ENSG00000214274	ANG	86	74.603	ENSRNOG00000025562	Ang2	75	74.603	Rattus_norvegicus
ENSG00000214274	ANG	86	74.603	ENSRNOG00000043032	Ang2	75	74.603	Rattus_norvegicus
ENSG00000214274	ANG	93	56.081	ENSSHAG00000006482	ANG	82	63.200	Sarcophilus_harrisii
ENSG00000214274	ANG	98	70.139	ENSSSCG00000031538	ANG	80	69.048	Sus_scrofa
ENSG00000214274	ANG	97	65.734	ENSTTRG00000009493	ANG	99	65.734	Tursiops_truncatus
ENSG00000214274	ANG	99	76.552	ENSUAMG00000012125	ANG	87	76.378	Ursus_americanus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001525	angiogenesis	8448182.	IDA	Process
GO:0001525	angiogenesis	2479414.17125737.	IMP	Process
GO:0001525	angiogenesis	16567967.	TAS	Process
GO:0001541	ovarian follicle development	12770725.	NAS	Process
GO:0001556	oocyte maturation	11438326.	NAS	Process
GO:0001666	response to hypoxia	10999833.15979542.16490744.	IDA	Process
GO:0001666	response to hypoxia	15776477.	NAS	Process
GO:0001890	placenta development	11984825.	NAS	Process
GO:0001938	positive regulation of endothelial cell proliferation	9122172.9707554.	IDA	Process
GO:0003677	DNA binding	10649442.	IC	Function
GO:0003779	actin binding	7679494.11782452.	IDA	Function
GO:0004519	endonuclease activity	10103013.	TAS	Function
GO:0004540	ribonuclease activity	21873635.	IBA	Function
GO:0004540	ribonuclease activity	2424496.2730651.	IDA	Function
GO:0005102	signaling receptor binding	9122172.	IDA	Function
GO:0005507	copper ion binding	9245697.	IDA	Function
GO:0005515	protein binding	2742853.3470787.10413501.15737636.17991437.24457100.28777577.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005604	basement membrane	15166501.	IDA	Component
GO:0005615	extracellular space	3663649.16461950.16490744.	IDA	Component
GO:0005634	nucleus	10649442.15735021.25372031.	IDA	Component
GO:0005730	nucleolus	-	ISS	Component
GO:0006651	diacylglycerol biosynthetic process	2457905.	IDA	Process
GO:0007154	cell communication	10103013.	NAS	Process
GO:0007202	activation of phospholipase C activity	2457905.	IMP	Process
GO:0008201	heparin binding	10103013.	IDA	Function
GO:0009303	rRNA transcription	15735021.	IMP	Process
GO:0009725	response to hormone	10999833.	IDA	Process
GO:0016477	cell migration	17125737.	IMP	Process
GO:0017148	negative regulation of translation	-	IEA	Process
GO:0019843	rRNA binding	2457905.	TAS	Function
GO:0030041	actin filament polymerization	-	ISS	Process
GO:0030426	growth cone	-	ISS	Component
GO:0031410	cytoplasmic vesicle	-	IEA	Component
GO:0032148	activation of protein kinase B activity	17125737.	IMP	Process
GO:0032311	angiogenin-PRI complex	3470787.	IDA	Component
GO:0032311	angiogenin-PRI complex	3470787.	IPI	Component
GO:0032431	activation of phospholipase A2 activity	2646638.	IMP	Process
GO:0034332	adherens junction organization	-	TAS	Process
GO:0042277	peptide binding	11782452.	IDA	Function
GO:0042327	positive regulation of phosphorylation	17125737.	IDA	Process
GO:0042592	homeostatic process	15166501.	NAS	Process
GO:0042803	protein homodimerization activity	25372031.	IDA	Function
GO:0043025	neuronal cell body	-	ISS	Component
GO:0048662	negative regulation of smooth muscle cell proliferation	10103013.	IDA	Process
GO:0050714	positive regulation of protein secretion	2646638.	IDA	Process
GO:0050714	positive regulation of protein secretion	-	ISS	Process
GO:0090501	RNA phosphodiester bond hydrolysis	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.