EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24253382	Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target.	Cancer Biol Ther	2014 Jan	Li J	doi: 10.4161/cbt.27146
19293187	PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.	Cancer Res	2009 Apr 1	Puustinen P	doi: 10.1158/0008-5472.CAN-08-2760
27048286	Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models.	Tumour Biol	2016 Sep	Pusey M	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr11	74246189	Silent	novel	K316K	0.96
BLCA	chr11	74247089	Silent	NA	R325R	0.46
BRCA	chr11	74203769	Missense_Mutation	NA	Q48R	0.13
BRCA	chr11	74222364	Missense_Mutation	rs780960664	S114N	0.08
BRCA	chr11	74171516	Missense_Mutation	NA	R32P	0.62
BRCA	chr11	74253687	3'UTR	novel		0.13
BRCA	chr11	74253618	3'UTR	novel		0.12
CESC	chr11	74254447	3'UTR	novel		0.44
CESC	chr11	74254511	3'UTR	novel		0.28
CESC	chr11	74222361	Missense_Mutation	NA	R113Q	0.07
CESC	chr11	74254324	3'UTR	novel		0.4
COAD	chr11	74230814	Intron	novel		0.19
COAD	chr11	74250988	Silent	novel	G348G	0.29
COAD	chr11	74204444	Missense_Mutation	rs79972734	T96M	0.32
COAD	chr11	74246139	Missense_Mutation	rs367984063	G300S	0.45
COAD	chr11	74253574	3'UTR	novel		0.18
COAD	chr11	74204359	Nonsense_Mutation	novel	R68*	0.09
ESCA	chr11	74230824	Intron	novel		0.47
GBM	chr11	74253507	Silent	NA	C386C	0.35
GBM	chr11	74230308	Silent	novel	G154G	0.46
GBM	chr11	74203783	Missense_Mutation	NA	M53L	0.28
HNSC	chr11	74239232	Missense_Mutation	novel	K270N	0.1
KIRC	chr11	74253539	3'UTR	novel		0.33
LUAD	chr11	74230277	Missense_Mutation	novel	G144E	0.12
LUAD	chr11	74203791	Silent	rs746920933	D55D	0.3
LUAD	chr11	74222327	Missense_Mutation	novel	R102G	0.16
LUAD	chr11	74239249	Missense_Mutation	NA	D276G	0.22
LUAD	chr11	74239186	Missense_Mutation	NA	I255K	0.34
LUAD	chr11	74230387	Missense_Mutation	novel	D181N	0.28
LUAD	chr11	74239189	Frame_Shift_Del	novel	*E257Kfs10**	0.1
LUSC	chr11	74230278	Silent	novel	G144G	0.23
LUSC	chr11	74230294	Missense_Mutation	rs771698562	I150V	0.2
MESO	chr11	74171359	5'UTR	novel		0.27
READ	chr11	74222361	Missense_Mutation	NA	R113Q	0.24
READ	chr11	74246201	Missense_Mutation	NA	L320F	0.31
READ	chr11	74203741	Missense_Mutation	rs199766005	R39W	0.26
SKCM	chr11	74247086	Missense_Mutation	novel	D324E	0.11
SKCM	chr11	74230269	Silent	NA	A141A	0.18
STAD	chr11	74239250	Silent	rs764593023	D276D	0.26
STAD	chr11	74222334	Missense_Mutation	NA	Q104R	0.26
THYM	chr11	74253728	3'UTR	novel		0.33
UCEC	chr11	74230793	Intron	novel		0.25
UCEC	chr11	74204446	Splice_Site	novel	X96_splice	0.7
UCEC	chr11	74204359	Nonsense_Mutation	novel	R68*	0.35
UCEC	chr11	74250987	Missense_Mutation	novel	G348A	0.37
UCEC	chr11	74254619	3'UTR	novel		0.16
UCEC	chr11	74253582	3'UTR	novel		0.43
UCEC	chr11	74230793	Intron	novel		0.5
UCEC	chr11	74204359	Nonsense_Mutation	novel	R68*	0.27
UCEC	chr11	74203818	Silent	novel	K64K	0.23
UCEC	chr11	74222361	Missense_Mutation	NA	R113Q	0.11
UCEC	chr11	74246176	Missense_Mutation	NA	C312Y	0.19
UCEC	chr11	74253557	3'UTR	rs373756930		0.26
UCEC	chr11	74230810	Intron	novel		0.29
UCEC	chr11	74253674	3'UTR	novel		0.06
UCEC	chr11	74253676	3'UTR	novel		0.06
UCEC	chr11	74253811	3'UTR	novel		0.27
UCEC	chr11	74230820	Intron	novel		0.43
UCEC	chr11	74254515	3'UTR	novel		0.3
UCEC	chr11	74246163	Missense_Mutation	novel	L308F	0.35
UCEC	chr11	74230927	Missense_Mutation	novel	A190E	0.45
UCEC	chr11	74222337	Missense_Mutation	novel	C105F	0.04
UCEC	chr11	74222338	Frame_Shift_Ins	novel	*R106Ifs21**	0.04
UCEC	chr11	74225258	Splice_Site	NA	X133_splice	0.37
UCEC	chr11	74225227	Silent	NA	P123P	0.08
UCEC	chr11	74251018	Missense_Mutation	novel	K358N	0.38
UCEC	chr11	74246104	Missense_Mutation	novel	R288I	0.22
UCEC	chr11	74246044	Intron	rs373148051		0.59
UCEC	chr11	74230798	Intron	rs761277731		0.31
UCEC	chr11	74254087	3'UTR	novel		0.25
UCEC	chr11	74254380	3'UTR	novel		0.32
UCEC	chr11	74254639	3'UTR	novel		0.28
UCEC	chr11	74254321	3'UTR	novel		0.48
UCEC	chr11	74254541	3'UTR	novel		0.49
UCEC	chr11	74222361	Missense_Mutation	NA	R113Q	0.16
UCEC	chr11	74253989	3'UTR	novel		0.4
UCEC	chr11	74254231	3'UTR	novel		0.28
UCEC	chr11	74222360	Nonsense_Mutation	novel	*G116Rfs8**	0
UCEC	chr11	74253730	3'UTR	novel		0.14
UCEC	chr11	74230833	Intron	novel		0.31
UCEC	chr11	74253545	3'UTR	novel		0.12
UCEC	chr11	74230814	Intron	novel		0.56
UCEC	chr11	74246148	Nonsense_Mutation	NA	R303*	0.42
UCEC	chr11	74254351	3'UTR	novel		0.43
UCEC	chr11	74246138	Silent	rs761061964	D299D	0.5
UCEC	chr11	74247821	Intron	novel		0.5
UCEC	chr11	74253560	3'UTR	rs776799516		0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.2717	0.018342
TGCT	DEL	0.7067	0.21504

Survival Analysis

Cancer	P-value	Q-value
THYM	0.033	Kaplan-Meier Survival Analysis
MESO	0.012	Kaplan-Meier Survival Analysis
ACC	0.0014	Kaplan-Meier Survival Analysis
HNSC	0.0057	Kaplan-Meier Survival Analysis
KIRP	0.02	Kaplan-Meier Survival Analysis
BLCA	0.011	Kaplan-Meier Survival Analysis
CESC	0.018	Kaplan-Meier Survival Analysis
KICH	0.0031	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
THCA	0.0037	Kaplan-Meier Survival Analysis
UVM	0.00014	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000214517 (Gene tree)
Gene ID: 51400
Gene Symbol: PPME1
Alias: PME-1|ABDH19
Full Name: protein phosphatase methylesterase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 83,813 bases
Position: chr11:74,170,891-74,254,703
Accession: 30178
RBP type: non-canonical RBP
Summary: This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000328257	PPME1-201	2677	-	ENSP00000329867	386 (aa)	-	Q9Y570
ENST00000539021	PPME1-205	4055	-	-	- (aa)	-	-
ENST00000542710	PPME1-207	590	-	-	- (aa)	-	-
ENST00000398427	PPME1-202	2496	-	ENSP00000381461	400 (aa)	-	Q9Y570
ENST00000535205	PPME1-203	636	-	-	- (aa)	-	-
ENST00000544401	PPME1-209	488	-	-	- (aa)	-	-
ENST00000541340	PPME1-206	3618	-	-	- (aa)	-	-
ENST00000538501	PPME1-204	744	-	-	- (aa)	-	-
ENST00000543525	PPME1-208	1928	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000214517's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000214517	Hip	2.24926776039999E-7	17903296

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000214517's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0004864	protein phosphatase inhibitor activity	10318862.	TAS	Function
GO:0005515	protein binding	22167190.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006482	protein demethylation	21873635.	IBA	Process
GO:0006482	protein demethylation	10318862.	IDA	Process
GO:0019888	protein phosphatase regulator activity	10318862.	TAS	Function
GO:0019901	protein kinase binding	-	IEA	Function
GO:0019903	protein phosphatase binding	10318862.	IDA	Function
GO:0032515	negative regulation of phosphoprotein phosphatase activity	-	IEA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0051721	protein phosphatase 2A binding	10318862.	IDA	Function
GO:0051722	protein C-terminal methylesterase activity	10318862.	IDA	Function
GO:0051722	protein C-terminal methylesterase activity	-	TAS	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.