EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29882471	MicroRNA-222 Promotes Invasion and Metastasis of Papillary Thyroid Cancer Through Targeting Protein Phosphatase 2 Regulatory Subunit B Alpha Expression.	Thyroid	2018 Sep	Huang Y	doi: 10.1089/thy.2017.0665
26054685	miR-892a regulated PPP2R2A expression and promoted cell proliferation of human colorectal cancer cells.	Biomed Pharmacother	2015 May	Liang WL	doi: 10.1016/j.biopha.2015.04.015
21872824	Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic study.	Cancer Genet	2011 Jul	Cheng Y	doi: 10.1016/j.cancergen.2011.05.002.
25879784	Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer.	BMC Cancer	2015 Apr 15	Beca F	doi: 10.1186/s12885-015-1266-1.
18670647	Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.	Neoplasia	2008 Aug	Liu W	-
26893480	PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling.	Cancer Res	2016 Apr 15	Hein AL	doi: 10.1158/0008-5472.CAN-15-2119
26297546	Upregulation of miR-556-5p promoted prostate cancer cell proliferation by suppressing PPP2R2A expression.	Biomed Pharmacother	2015 Oct	Zhao W	doi: 10.1016/j.biopha.2015.07.015
26800397	miR-222 attenuates cisplatin-induced cell death by targeting the PPP2R2A/Akt/mTOR Axis in bladder cancer cells.	J Cell Mol Med	2016 Mar	Zeng LP	doi: 10.1111/jcmm.12760
29532877	Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression.	Mol Med Rep	2018 May	Zhang J	doi: 10.3892/mmr.2018.8714
29943541	[PPP2R2A binds and dephosphorylates GFPT2 in breast cancer cells].	Sheng Wu Gong Cheng Xue Bao	2018 Jun 25	Li X	doi: 10.13345/j.cjb.170471.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr8	26360205	Missense_Mutation	novel	D128V	0.24
BLCA	chr8	26361082	Missense_Mutation	novel	E190K	0.18
BLCA	chr8	26370517	3'UTR	novel		0.42
BLCA	chr8	26291759	5'UTR	novel		0.83
BLCA	chr8	26370384	Silent	NA	L439L	0.38
BRCA	chr8	26370139	Missense_Mutation	NA	V357D	0.67
BRCA	chr8	26362683	Splice_Site	novel	X213_splice	0.12
BRCA	chr8	26363773	Silent	rs367623623	I285I	0.51
BRCA	chr8	26291799	5'UTR	novel		0.38
BRCA	chr8	26291812	5'UTR	rs376237331		0.12
CESC	chr8	26360180	Missense_Mutation	NA	K120Q	0.32
CESC	chr8	26370214	Missense_Mutation	novel	S382L	0.2
CESC	chr8	26360198	Missense_Mutation	NA	E126K	0.37
COAD	chr8	26362771	Missense_Mutation	novel	F242S	0.08
COAD	chr8	26291736	5'UTR	novel		0.3
COAD	chr8	26354481	Missense_Mutation	novel	S65Y	0.06
COAD	chr8	26370229	Missense_Mutation	novel	K387T	0.09
COAD	chr8	26360203	Silent	novel	R127R	0.32
COAD	chr8	26370436	3'UTR	novel		0.31
COAD	chr8	26291737	5'UTR	novel		0.45
COAD	chr8	26291736	5'UTR	novel		0.29
COAD	chr8	26354599	Frame_Shift_Ins	novel	*N106Kfs11**	0.37
COAD	chr8	26291722	5'UTR	novel		0.45
COAD	chr8	26291737	5'UTR	novel		0.11
COAD	chr8	26362830	Missense_Mutation	NA	C262G	0.25
COAD	chr8	26291698	5'UTR	novel		0.27
COAD	chr8	26291737	5'UTR	novel		0.34
COAD	chr8	26363756	Frame_Shift_Del	NA	*S282Pfs10**	0.46
COAD	chr8	26291678	5'UTR	novel		0.42
COAD	chr8	26363756	Frame_Shift_Del	NA	*S282Pfs10**	0.37
COAD	chr8	26354533	Silent	novel	P82P	0.1
COAD	chr8	26361087	Silent	NA	T191T	0.09
COAD	chr8	26366369	Missense_Mutation	NA	F343V	0.14
COAD	chr8	26370319	Missense_Mutation	novel	K417T	0.18
COAD	chr8	26338928	Nonsense_Mutation	NA	E41*	0.28
COAD	chr8	26291737	5'UTR	novel		0.37
COAD	chr8	26361142	In_Frame_Ins	novel	R210delinsTW	0.04
COAD	chr8	26361144	Silent	novel	R210R	0.02
ESCA	chr8	26362809	Missense_Mutation	novel	D255N	0.19
ESCA	chr8	26370826	3'UTR	novel		0.22
GBM	chr8	26354495	Nonsense_Mutation	novel	E70*	0.41
GBM	chr8	26370498	3'UTR	novel		0.67
GBM	chr8	26370321	Nonsense_Mutation	novel	K418*	0.15
HNSC	chr8	26362814	Missense_Mutation	NA	M256I	0.16
HNSC	chr8	26370183	Missense_Mutation	novel	N372D	0.2
HNSC	chr8	26291776	5'UTR	novel		0.14
KIRC	chr8	26360220	Missense_Mutation	NA	G133V	0.11
KIRP	chr8	26362817	Silent	novel	R257R	0.34
KIRP	chr8	26291684	5'UTR	novel		0.6
KIRP	chr8	26354475	Missense_Mutation	rs373174942	I63T	0.33
KIRP	chr8	26370330	Frame_Shift_Del	novel	*H421Qfs12**	0.32
LAML	chr8	26293714	Missense_Mutation	novel	G19V	0.09
LGG	chr8	26370453	3'UTR	rs757896097		0.16
LGG	chr8	26370228	In_Frame_Del	novel	T390_R395del	0.42
LGG	chr8	26338895	Missense_Mutation	novel	I30V	0.39
LGG	chr8	26360253	Missense_Mutation	novel	R144I	0.11
LGG	chr8	26363817	Missense_Mutation	novel	M300T	0.32
LIHC	chr8	26366361	Missense_Mutation	novel	D340G	0.32
LIHC	chr8	26362835	Silent	novel	D263D	0.33
LIHC	chr8	26291571	5'UTR	novel		0.59
LUAD	chr8	26360282	Splice_Site	novel	X153_splice	0.16
LUAD	chr8	26366354	Missense_Mutation	NA	E338K	0.08
LUAD	chr8	26354522	Missense_Mutation	NA	S79G	0.14
LUAD	chr8	26354558	Nonsense_Mutation	novel	E91*	0.12
LUAD	chr8	26370286	Missense_Mutation	novel	D406V	0.07
LUAD	chr8	26354534	Nonsense_Mutation	novel	E83*	0.31
LUAD	chr8	26360985	Frame_Shift_Ins	novel	*R158Kfs8**	0.11
LUAD	chr8	26362814	Missense_Mutation	NA	M256I	0.26
LUSC	chr8	26361110	Missense_Mutation	rs759228133	R199Q	0.42
LUSC	chr8	26361016	Missense_Mutation	NA	P168S	0.15
LUSC	chr8	26370177	Missense_Mutation	NA	D370H	0.19
LUSC	chr8	26363810	Nonsense_Mutation	NA	R298*	0.22
OV	chr8	26370337	Missense_Mutation	NA	A423V	0.53
OV	chr8	26354516	Missense_Mutation	NA	F77L	0.29
OV	chr8	26362849	Splice_Site	novel	X268_splice	0.13
OV	chr8	26363885	Splice_Site	novel	X323_splice	0.77
PAAD	chr8	26293692	Missense_Mutation	novel	W12R	0.18
PAAD	chr8	26370275	Missense_Mutation	novel	K402N	0.06
READ	chr8	26291737	5'UTR	novel		0.31
READ	chr8	26370390	Missense_Mutation	novel	I441V	0.23
READ	chr8	26370215	Silent	novel	S382S	0.33
READ	chr8	26338928	Nonsense_Mutation	NA	E41*	0.22
SARC	chr8	26361039	Silent	novel	A175A	0.4
SARC	chr8	26370309	Missense_Mutation	novel	D414H	0.21
SKCM	chr8	26354571	Missense_Mutation	NA	K95M	0.16
SKCM	chr8	26366369	Missense_Mutation	NA	F343V	0.06
SKCM	chr8	26338971	Missense_Mutation	NA	F55S	0.46
SKCM	chr8	26363810	Nonsense_Mutation	NA	R298*	0.53
SKCM	chr8	26360188	Nonsense_Mutation	NA	W122*	0.21
SKCM	chr8	26363784	Missense_Mutation	rs757712148	S289L	0.3
SKCM	chr8	26360982	Silent	NA	V156V	0.45
SKCM	chr8	26363763	Missense_Mutation	NA	S282F	0.41
SKCM	chr8	26370147	Missense_Mutation	NA	G360R	0.71
STAD	chr8	26360991	Silent	NA	P159P	0.24
STAD	chr8	26363765	Missense_Mutation	rs146354435	E283K	0.16
STAD	chr8	26370276	Nonsense_Mutation	NA	R403*	0.16
STAD	chr8	26370508	3'UTR	rs377473455		0.26
STAD	chr8	26370177	Missense_Mutation	NA	D370H	0.08
STAD	chr8	26291737	5'UTR	novel		0.42
STAD	chr8	26293674	Nonsense_Mutation	novel	G6*	0.14
STAD	chr8	26362801	Missense_Mutation	NA	R252Q	0.29
STAD	chr8	26370235	Missense_Mutation	rs369862992	R389H	0.26
STAD	chr8	26362722	Missense_Mutation	NA	T226P	0.1
STAD	chr8	26370405	Missense_Mutation	NA	V446M	0.06
STAD	chr8	26363845	Missense_Mutation	NA	K309N	0.07
TGCT	chr8	26291591	5'UTR	rs542815499		0.09
THCA	chr8	26370472	3'UTR	novel		0.08
THCA	chr8	26370473	3'UTR	novel		0.08
THYM	chr8	26370192	Nonsense_Mutation	novel	R375*	0.2
THYM	chr8	26370235	Missense_Mutation	rs369862992	R389H	0.24
UCEC	chr8	26293727	Silent	novel	D23D	0.49
UCEC	chr8	26363812	Silent	novel	R298R	0.44
UCEC	chr8	26370944	3'UTR	novel		0.45
UCEC	chr8	26338898	Missense_Mutation	NA	I31L	0.49
UCEC	chr8	26366408	Splice_Site	novel	X355_splice	0.05
UCEC	chr8	26370236	Silent	NA	R389R	0.08
UCEC	chr8	26370341	Nonsense_Mutation	NA	W424*	0.48
UCEC	chr8	26371091	3'UTR	novel		0.32
UCEC	chr8	26363784	Missense_Mutation	rs757712148	S289L	0.06
UCEC	chr8	26363818	Missense_Mutation	NA	M300I	0.24
UCEC	chr8	26354592	Missense_Mutation	novel	L102S	0.43
UCEC	chr8	26291813	5'UTR	novel		0.29
UCEC	chr8	26362800	Missense_Mutation	NA	R252W	0.32
UCEC	chr8	26360208	Missense_Mutation	novel	K129T	0.41
UCEC	chr8	26360180	Missense_Mutation	NA	K120Q	0.07
UCEC	chr8	26362795	Missense_Mutation	novel	T250N	0.27
UCEC	chr8	26370614	3'UTR	novel		0.3
UCEC	chr8	26366335	Silent	NA	S331S	0.2
UCEC	chr8	26366401	Silent	novel	S353S	0.37
UCEC	chr8	26338928	Nonsense_Mutation	NA	E41*	0.48
UCEC	chr8	26363785	Silent	NA	S289S	0.36
UCEC	chr8	26370983	3'UTR	novel		0.53
UCEC	chr8	26370471	3'UTR	novel		0.24
UCEC	chr8	26360211	Missense_Mutation	novel	R130I	0.35
UCEC	chr8	26361020	Missense_Mutation	NA	R169Q	0.38
UCEC	chr8	26371091	3'UTR	novel		0.55
UCEC	chr8	26370214	Missense_Mutation	novel	S382L	0.37
UCEC	chr8	26370496	3'UTR	novel		0.29
UCEC	chr8	26338943	Nonsense_Mutation	novel	G46*	0.2
UCEC	chr8	26370243	Silent	novel	L392L	0.59
UCEC	chr8	26370797	3'UTR	novel		0.42
UCEC	chr8	26370489	3'UTR	novel		0.31
UCEC	chr8	26293249	Intron	novel		0.18
UCEC	chr8	26360977	Missense_Mutation	NA	P155S	0.3
UCEC	chr8	26370369	Missense_Mutation	novel	A434S	0.06
UCEC	chr8	26370250	Missense_Mutation	novel	P394H	0.36
UCEC	chr8	26361020	Missense_Mutation	NA	R169Q	0.48
UCEC	chr8	26361127	Missense_Mutation	novel	L205M	0.22
UCEC	chr8	26363810	Nonsense_Mutation	NA	R298*	0.15
UCEC	chr8	26370295	Missense_Mutation	novel	S409I	0.19
UCEC	chr8	26362801	Missense_Mutation	NA	R252Q	0.2
UCEC	chr8	26362722	Missense_Mutation	novel	T226A	0.24
UCS	chr8	26370476	3'UTR	novel		0.24
UVM	chr8	26354572	Missense_Mutation	novel	K95N	0.27

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.5515	4.5185e-08
DLBC	DEL	0.2292	0.15679
ESCA	DEL	0.4185	0.060925
OV	DEL	0.6926	1.6864e-37
PAAD	DEL	0.2337	0.050455
READ	DEL	0.5697	0.20625
UCEC	DEL	0.2078	1.6228e-10
UCS	DEL	0.5179	0.0031922

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00031	Kaplan-Meier Survival Analysis
HNSC	0.017	Kaplan-Meier Survival Analysis
SKCM	0.011	Kaplan-Meier Survival Analysis
KIRP	0.014	Kaplan-Meier Survival Analysis
COAD	0.028	Kaplan-Meier Survival Analysis
PAAD	0.021	Kaplan-Meier Survival Analysis
READ	0.028	Kaplan-Meier Survival Analysis
KICH	0.0053	Kaplan-Meier Survival Analysis
GBM	0.028	Kaplan-Meier Survival Analysis
LIHC	0.033	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000221914 (Gene tree)
Gene ID: 5520
Gene Symbol: PPP2R2A
Alias: PR52A|PR55A|B55A|PR55alpha|B55alpha
Full Name: protein phosphatase 2 regulatory subunit Balpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 81,190 bases
Position: chr8:26,291,491-26,372,680
Accession: 9304
RBP type: non-canonical RBP
Summary: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000518254	PPP2R2A-206	755	-	ENSP00000428164	51 (aa)	-	E5RJV2
ENST00000518215	PPP2R2A-205	1163	-	-	- (aa)	-	-
ENST00000522150	PPP2R2A-216	573	-	-	- (aa)	-	-
ENST00000519636	PPP2R2A-210	575	-	-	- (aa)	-	-
ENST00000523964	PPP2R2A-221	567	-	-	- (aa)	-	-
ENST00000518397	PPP2R2A-207	830	-	ENSP00000429279	132 (aa)	-	E5RIY1
ENST00000523925	PPP2R2A-220	529	-	ENSP00000428800	5 (aa)	-	UPI0001E8EF84
ENST00000524169	PPP2R2A-223	784	XM_005273560	ENSP00000430320	197 (aa)	XP_005273617	E5RFR9
ENST00000521557	PPP2R2A-215	601	-	ENSP00000428165	14 (aa)	-	E5RJV1
ENST00000523473	PPP2R2A-219	654	-	-	- (aa)	-	-
ENST00000517754	PPP2R2A-203	2357	-	-	- (aa)	-	-
ENST00000522535	PPP2R2A-218	653	-	ENSP00000428705	3 (aa)	-	UPI000044C467
ENST00000315985	PPP2R2A-201	1878	XM_011544565	ENSP00000325074	457 (aa)	XP_011542867	P63151
ENST00000518890	PPP2R2A-208	1237	-	-	- (aa)	-	-
ENST00000380737	PPP2R2A-202	3940	XM_005273559	ENSP00000370113	447 (aa)	XP_005273616	P63151
ENST00000519439	PPP2R2A-209	658	-	-	- (aa)	-	-
ENST00000518208	PPP2R2A-204	1490	-	-	- (aa)	-	-
ENST00000520329	PPP2R2A-211	836	-	ENSP00000428542	33 (aa)	-	E5RHQ2
ENST00000522482	PPP2R2A-217	576	-	-	- (aa)	-	-
ENST00000521095	PPP2R2A-213	579	-	-	- (aa)	-	-
ENST00000521484	PPP2R2A-214	556	-	-	- (aa)	-	-
ENST00000524099	PPP2R2A-222	569	-	-	- (aa)	-	-
ENST00000520438	PPP2R2A-212	409	-	-	- (aa)	-	-
ENST00000640787	PPP2R2A-224	318	-	ENSP00000491731	105 (aa)	-	A0A1W2PQI2

Gene Model

Click here to download ENSG00000221914's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG
hsa04071	Sphingolipid signaling pathway	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04152	AMPK signaling pathway	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa04530	Tight junction	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa05142	Chagas disease (American trypanosomiasis)	KEGG
hsa05160	Hepatitis C	KEGG
hsa05165	Human papillomavirus infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000221914	Antihypertensive Agents	7.3460000E-005	-
ENSG00000221914	Body Height	4E-8	23563607

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000221914	rs1594829	8	26348561	C	Height	23563607	[NR]	1.15	EFO_0004339
ENSG00000221914	rs190324086	8	26312674	?	Reaction time	29844566	[0.0045-0.0113] unit decrease	0.0079173	EFO_0008393
ENSG00000221914	rs191610380	8	26368897	?	Aspartate aminotransferase levels in excessive alcohol consumption	30589442	[0.02-0.044] unit increase	0.0318	EFO_0004736\|EFO_0007878

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000221914's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000221914	PPP2R2A	100	82.741	FBgn0004889	tws	99	79.138	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0000159	protein phosphatase type 2A complex	21873635.	IBA	Component
GO:0000159	protein phosphatase type 2A complex	1849734.17245430.	IDA	Component
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	Process
GO:0000278	mitotic cell cycle	21873635.	IBA	Process
GO:0004722	protein serine/threonine phosphatase activity	21873635.	IBA	Function
GO:0004722	protein serine/threonine phosphatase activity	1849734.	IDA	Function
GO:0005515	protein binding	9847399.15761952.17245430.17529992.17540176.17632056.18782753.19156129.19293187.19915589.20711181.25816751.26496610.27173435.27588481.28330616.28609714.30611118.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006470	protein dephosphorylation	1849734.	IDA	Process
GO:0007084	mitotic nuclear envelope reassembly	-	TAS	Process
GO:0019888	protein phosphatase regulator activity	1849734.	TAS	Function
GO:0043278	response to morphine	-	IEA	Process
GO:0043666	regulation of phosphoprotein phosphatase activity	-	IEA	Process
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0048156	tau protein binding	-	IEA	Function
GO:0051721	protein phosphatase 2A binding	-	IEA	Function
GO:0070262	peptidyl-serine dephosphorylation	21873635.	IBA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.