EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28061504	DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins.	PLoS One	2017 Jan 6	Nguyen HT	doi: 10.1371/journal.pone.0169587
25776484	Dub3 expression correlates with tumor progression and poor prognosis in human epithelial ovarian cancer.	Biomed Pharmacother	2015 Mar	Zhou B	doi: 10.1016/j.biopha.2015.01.015
30718431	MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer.	Proc Natl Acad Sci U S A	2019 Feb 19	Wu X	doi: 10.1073/pnas.1814742116
28288134	DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.	Oncogene	2017 Aug 17	Hernandez-Perez S	doi: 10.1038/onc.2017.21
30057199	DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.	Mol Cell	2018 Aug 16	Jin X	doi: 10.1016/j.molcel.2018.06.036

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr8	12138592	Missense_Mutation	novel	P57T	0.18
BLCA	chr8	12138482	Silent	novel	A93A	0.47
BLCA	chr8	12138205	Missense_Mutation	novel	H186Y	0.18
BLCA	chr8	12138563	Silent	NA	K66K	0.09
BLCA	chr8	12138350	Silent	rs780196046	H137H	0.37
BLCA	chr8	12137497	Missense_Mutation	rs375221330	E422K	0.36	HABP4_PAI-RBP1
BLCA	chr8	12138516	Missense_Mutation	novel	L82H	0.37
BRCA	chr8	12137651	Silent	NA	L370L	0.21
CESC	chr8	12137912	Missense_Mutation	NA	F283L	0.16
CESC	chr8	12137576	Silent	rs779644781	G395G	0.08
CESC	chr8	12137289	Missense_Mutation	rs756802111	S491L	0.19
CESC	chr8	12138055	Missense_Mutation	novel	A236T	0.24
CESC	chr8	12138237	Missense_Mutation	novel	A175V	0.13
CESC	chr8	12137534	Missense_Mutation	rs774997041	K409N	0.08	HABP4_PAI-RBP1
CESC	chr8	12138340	Missense_Mutation	NA	H141Y	0.73
CESC	chr8	12138730	Missense_Mutation	rs550178667	E11Q	0.51
CESC	chr8	12138480	Frame_Shift_Ins	novel	*S94Ffs62**	0.22
COAD	chr8	12137408	Silent	rs371227729	N451N	0.17
COAD	chr8	12138425	Missense_Mutation	NA	E112D	0.26
COAD	chr8	12138515	Silent	novel	L82L	0.26
COAD	chr8	12137355	Nonsense_Mutation	rs201297814	S469*	0.36
COAD	chr8	12138493	Missense_Mutation	novel	Y90H	0.13
COAD	chr8	12137395	Missense_Mutation	rs200378249	E456K	0.14
COAD	chr8	12137587	Missense_Mutation	novel	R392G	0.13	HABP4_PAI-RBP1
COAD	chr8	12137715	Missense_Mutation	novel	M349T	0.21
COAD	chr8	12138455	Silent	rs780960345	P102P	0.14
COAD	chr8	12137239	Missense_Mutation	NA	L508V	0.31
COAD	chr8	12138748	Missense_Mutation	novel	S5P	0.1
COAD	chr8	12137395	Missense_Mutation	rs200378249	E456K	0.27
COAD	chr8	12137665	Missense_Mutation	rs536115308	Q366K	0.26
COAD	chr8	12137309	Silent	rs747131547	S484S	0.14
DLBC	chr8	12137286	Missense_Mutation	rs201012791	T492M	0.27
ESCA	chr8	12138650	Silent	rs368449254	L37L	0.09
ESCA	chr8	12137263	Missense_Mutation	rs199889083	V500M	0.66
ESCA	chr8	12137789	Silent	novel	V324V	0.12
ESCA	chr8	12138573	Missense_Mutation	novel	A63V	0.19
ESCA	chr8	12138679	Missense_Mutation	novel	A28T	0.06
ESCA	chr8	12137576	Silent	rs779644781	G395G	0.08
GBM	chr8	12138531	Missense_Mutation	rs373630969	A77V	0.24
GBM	chr8	12137804	Silent	novel	L319L	0.16
GBM	chr8	12137753	Silent	novel	F336F	0.18
GBM	chr8	12138639	Missense_Mutation	novel	S41L	0.11
GBM	chr8	12137263	Missense_Mutation	rs199889083	V500M	0.82
HNSC	chr8	12137188	Missense_Mutation	rs779810100	A525S	0.22
HNSC	chr8	12138544	Missense_Mutation	novel	R73G	0.14
HNSC	chr8	12138537	Missense_Mutation	NA	P75L	0.05
HNSC	chr8	12138664	Missense_Mutation	novel	Q33K	0.15
HNSC	chr8	12137185	Missense_Mutation	novel	L526V	0.09
HNSC	chr8	12138073	Missense_Mutation	rs778312568	A230S	0.2
HNSC	chr8	12138327	Missense_Mutation	novel	P145L	0.36
HNSC	chr8	12137639	Missense_Mutation	NA	Q374H	0.11
LIHC	chr8	12137859	Missense_Mutation	rs528142888	L301P	0.09
LIHC	chr8	12137593	Missense_Mutation	NA	E390K	0.33	HABP4_PAI-RBP1
LUAD	chr8	12137973	Missense_Mutation	novel	A263D	0.37
LUAD	chr8	12137319	Missense_Mutation	rs776605778	E481V	0.07
LUAD	chr8	12138245	Missense_Mutation	novel	M172I	0.27
LUAD	chr8	12137522	Silent	novel	P413P	0.05
LUAD	chr8	12137464	Missense_Mutation	NA	T433P	0.2	HABP4_PAI-RBP1
LUAD	chr8	12137971	Missense_Mutation	NA	S264T	0.09
LUAD	chr8	12138468	Missense_Mutation	NA	L98Q	0.26
LUAD	chr8	12137418	Missense_Mutation	novel	P448H	0.17	HABP4_PAI-RBP1
LUAD	chr8	12138758	Translation_Start_Site	novel	M1?	0.08
LUSC	chr8	12137933	Silent	novel	L276L	0.13
LUSC	chr8	12137784	Missense_Mutation	NA	A326V	0.3
LUSC	chr8	12138279	Missense_Mutation	NA	A161D	0.26
LUSC	chr8	12138237	Missense_Mutation	novel	A175V	0.35
LUSC	chr8	12137522	Silent	NA	P413P	0.39
LUSC	chr8	12138257	Silent	novel	T168T	0.13
LUSC	chr8	12138494	Nonsense_Mutation	novel	C89*	0.26
LUSC	chr8	12138432	Missense_Mutation	novel	S110Y	0.33
LUSC	chr8	12137308	Missense_Mutation	novel	S485T	0.11
LUSC	chr8	12138322	Missense_Mutation	novel	Q147K	0.21
LUSC	chr8	12137894	Missense_Mutation	novel	N289K	0.19
LUSC	chr8	12137440	Missense_Mutation	novel	Q441E	0.45	HABP4_PAI-RBP1
LUSC	chr8	12138080	Silent	novel	I227I	0.67
LUSC	chr8	12137548	Missense_Mutation	novel	Q405K	0.06	HABP4_PAI-RBP1
PAAD	chr8	12137502	Nonsense_Mutation	novel	L420*	0.05	HABP4_PAI-RBP1
PAAD	chr8	12137244	Missense_Mutation	novel	A506V	0.13
PAAD	chr8	12137630	Missense_Mutation	novel	E377D	0.15
PAAD	chr8	12137994	Missense_Mutation	novel	L256P	0.09
PCPG	chr8	12138436	Silent	rs761267593	L109L	0.3
READ	chr8	12138028	Nonsense_Mutation	novel	E245*	0.28
READ	chr8	12138268	Missense_Mutation	NA	L165I	0.31
READ	chr8	12137289	Missense_Mutation	rs756802111	S491L	0.16
SARC	chr8	12137889	Missense_Mutation	novel	L291P	0.27
SARC	chr8	12137516	Silent	novel	L415L	0.66
SKCM	chr8	12137232	Missense_Mutation	NA	G510E	0.32
SKCM	chr8	12138085	Missense_Mutation	novel	D226N	0.28
SKCM	chr8	12137396	Silent	rs374973302	V455V	0.28
SKCM	chr8	12137486	Silent	novel	V425V	0.18
SKCM	chr8	12137563	Missense_Mutation	NA	D400N	0.16	HABP4_PAI-RBP1
SKCM	chr8	12137593	Missense_Mutation	NA	E390K	0.33	HABP4_PAI-RBP1
SKCM	chr8	12138608	Silent	novel	L51L	0.29
SKCM	chr8	12138127	Missense_Mutation	NA	G212R	0.32
SKCM	chr8	12137336	Missense_Mutation	NA	M475I	0.64
SKCM	chr8	12138570	Missense_Mutation	NA	P64L	0.26
SKCM	chr8	12137335	Missense_Mutation	NA	K476E	0.13
SKCM	chr8	12137595	Missense_Mutation	rs763172737	R389K	0.34	HABP4_PAI-RBP1
SKCM	chr8	12137776	Missense_Mutation	NA	S329C	0.15
SKCM	chr8	12137778	Nonsense_Mutation	rs752949096	W328*	0.16
SKCM	chr8	12137169	Silent	NA	*531*	0.15
SKCM	chr8	12138542	Silent	rs760816302	R73R	0.12
SKCM	chr8	12137868	Missense_Mutation	NA	P298L	0.06
SKCM	chr8	12137386	Silent	rs761564697	L459L	0.14
SKCM	chr8	12137537	Silent	novel	L408L	0.18
SKCM	chr8	12138286	Missense_Mutation	rs151245022	E159K	0.2
SKCM	chr8	12138537	Missense_Mutation	NA	P75L	0.06
SKCM	chr8	12137229	Missense_Mutation	NA	R511K	0.32
SKCM	chr8	12137450	Nonsense_Mutation	NA	W437*	0.25	HABP4_PAI-RBP1
SKCM	chr8	12137530	Missense_Mutation	novel	D411N	0.12	HABP4_PAI-RBP1
SKCM	chr8	12138620	Silent	novel	A47A	0.15
SKCM	chr8	12138283	Missense_Mutation	rs766015132	D160N	0.11
SKCM	chr8	12138504	Missense_Mutation	rs770234887	G86E	0.13
SKCM	chr8	12138467	Silent	novel	L98L	0.88
SKCM	chr8	12137187	Missense_Mutation	novel	A525V	0.31
SKCM	chr8	12137362	Missense_Mutation	NA	H467Y	0.13
SKCM	chr8	12137198	Missense_Mutation	novel	H521Q	0.26
SKCM	chr8	12137556	Missense_Mutation	rs267601744	R402P	0.06	HABP4_PAI-RBP1
SKCM	chr8	12138070	Nonsense_Mutation	novel	Q231*	0.34
SKCM	chr8	12137473	Nonsense_Mutation	novel	Q430*	0.34	HABP4_PAI-RBP1
SKCM	chr8	12138526	Missense_Mutation	NA	G79R	0.12
SKCM	chr8	12137714	Missense_Mutation	rs764837008	M349I	0.68
SKCM	chr8	12138289	Nonsense_Mutation	NA	Q158*	0.12
SKCM	chr8	12137336	Missense_Mutation	NA	M475I	0.45
STAD	chr8	12137264	Silent	rs772277926	S499S	0.03
STAD	chr8	12138064	Missense_Mutation	novel	V233I	0.36
STAD	chr8	12137663	Missense_Mutation	NA	Q366H	0.13
STAD	chr8	12138674	Missense_Mutation	novel	F29L	0.4
STAD	chr8	12137288	Silent	rs375258900	S491S	0.68
STAD	chr8	12138413	Silent	rs3988862	T116T	0.44
STAD	chr8	12138313	Missense_Mutation	novel	A150T	0.07
STAD	chr8	12137908	Missense_Mutation	NA	D285Y	0.08
STAD	chr8	12138695	Silent	novel	S22S	0.12
STAD	chr8	12137583	Missense_Mutation	NA	A393V	0.17	HABP4_PAI-RBP1
STAD	chr8	12137283	Missense_Mutation	NA	T493N	0.05
UCEC	chr8	12138470	Nonsense_Mutation	NA	C97*	0.16
UCEC	chr8	12138442	Missense_Mutation	rs755279564	Y107H	0.31
UCEC	chr8	12138016	Missense_Mutation	novel	E249K	0.35
UCEC	chr8	12137690	Silent	NA	C357C	0.5
UCEC	chr8	12138313	Missense_Mutation	novel	A150T	0.36
UCEC	chr8	12138611	Silent	novel	D50D	0.21
UCEC	chr8	12138359	Missense_Mutation	rs772037870	W134C	0.25
UCEC	chr8	12137867	Silent	novel	P298P	0.21
UCEC	chr8	12138424	Missense_Mutation	novel	H113Y	0.17
UCEC	chr8	12137869	Missense_Mutation	rs779827922	P298T	0.13
UCEC	chr8	12137861	Silent	novel	C300C	0.25
UCEC	chr8	12138130	Missense_Mutation	novel	H211N	0.3
UCEC	chr8	12137661	Missense_Mutation	novel	A367V	0.38
UCEC	chr8	12138225	Missense_Mutation	novel	G179D	0.19
UCEC	chr8	12137653	Missense_Mutation	novel	L370F	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.5466	4.5185e-08
DLBC	DEL	0.2083	0.15679
ESCA	AMP	0.2337	2.785e-07
PAAD	DEL	0.2283	0.050455
READ	DEL	0.5576	0.20625
UCS	DEL	0.5357	0.0031922

Survival Analysis

Cancer	P-value	Q-value
LAML	0.024	Kaplan-Meier Survival Analysis

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000223443 (Gene tree)
Gene ID: 377630
Gene Symbol: USP17L2
Alias: DUB3
Full Name: ubiquitin specific peptidase 17 like family member 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 1,910 bases
Position: chr8:12,137,168-12,139,077
Accession: 34434
RBP type: canonical RBP
Summary: DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000333329	HABP4_PAI-RBP1	PF04774.15	0.0014	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17109758	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	BMC Genomics	2006 Nov 16	Shin JM	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000333796	USP17L2-201	1910	-	ENSP00000333329	530 (aa)	-	Q6R6M4

Gene Model

Click here to download ENSG00000223443's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000223443's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000223443	USP17L2	100	94.340	ENSGGOG00000042639	-	100	94.340	Gorilla_gorilla
ENSG00000223443	USP17L2	74	95.475	ENSGGOG00000009925	-	94	95.475	Gorilla_gorilla
ENSG00000223443	USP17L2	100	87.170	ENSGGOG00000043616	-	100	87.170	Gorilla_gorilla
ENSG00000223443	USP17L2	78	94.712	ENSGGOG00000014367	-	100	94.712	Gorilla_gorilla
ENSG00000223443	USP17L2	100	94.340	ENSGGOG00000044031	-	100	94.340	Gorilla_gorilla
ENSG00000223443	USP17L2	100	88.491	ENSMFAG00000043645	-	95	88.491	Macaca_fascicularis
ENSG00000223443	USP17L2	87	88.961	ENSMFAG00000039016	-	100	88.961	Macaca_fascicularis
ENSG00000223443	USP17L2	100	88.491	ENSMFAG00000036389	-	95	88.491	Macaca_fascicularis
ENSG00000223443	USP17L2	100	88.302	ENSMMUG00000049137	-	100	88.302	Macaca_mulatta
ENSG00000223443	USP17L2	100	88.302	ENSMMUG00000040484	-	100	88.302	Macaca_mulatta
ENSG00000223443	USP17L2	100	88.491	ENSMMUG00000047519	-	100	88.491	Macaca_mulatta
ENSG00000223443	USP17L2	100	86.604	ENSMMUG00000039802	-	100	86.604	Macaca_mulatta
ENSG00000223443	USP17L2	100	89.057	ENSMMUG00000041878	-	100	89.057	Macaca_mulatta
ENSG00000223443	USP17L2	100	81.887	ENSMMUG00000044213	-	100	81.887	Macaca_mulatta
ENSG00000223443	USP17L2	100	88.113	ENSMMUG00000041488	-	100	88.113	Macaca_mulatta
ENSG00000223443	USP17L2	99	87.689	ENSMMUG00000045288	-	95	87.689	Macaca_mulatta
ENSG00000223443	USP17L2	100	83.774	ENSMMUG00000042380	-	96	83.774	Macaca_mulatta
ENSG00000223443	USP17L2	100	88.113	ENSMMUG00000049096	-	96	88.113	Macaca_mulatta
ENSG00000223443	USP17L2	100	88.113	ENSMMUG00000042715	-	100	88.113	Macaca_mulatta
ENSG00000223443	USP17L2	100	88.302	ENSMMUG00000029040	-	96	88.302	Macaca_mulatta
ENSG00000223443	USP17L2	99	79.735	ENSMNEG00000033266	-	96	80.114	Macaca_nemestrina
ENSG00000223443	USP17L2	100	77.444	ENSMLEG00000029099	-	100	77.444	Mandrillus_leucophaeus
ENSG00000223443	USP17L2	100	92.075	ENSNLEG00000035477	-	100	92.075	Nomascus_leucogenys
ENSG00000223443	USP17L2	100	84.717	ENSPTRG00000049794	-	100	84.717	Pan_troglodytes
ENSG00000223443	USP17L2	86	81.271	ENSPANG00000034816	-	92	81.271	Papio_anubis
ENSG00000223443	USP17L2	100	88.491	ENSPANG00000029674	-	100	88.491	Papio_anubis
ENSG00000223443	USP17L2	100	90.476	ENSPANG00000035429	-	100	90.476	Papio_anubis
ENSG00000223443	USP17L2	100	88.491	ENSPANG00000031953	-	100	88.491	Papio_anubis
ENSG00000223443	USP17L2	100	87.547	ENSPANG00000035655	-	100	87.547	Papio_anubis
ENSG00000223443	USP17L2	89	87.764	ENSPANG00000032780	-	100	87.764	Papio_anubis
ENSG00000223443	USP17L2	100	87.547	ENSPANG00000032302	-	100	87.547	Papio_anubis
ENSG00000223443	USP17L2	100	87.170	ENSPANG00000029660	-	100	87.170	Papio_anubis
ENSG00000223443	USP17L2	100	85.849	ENSRROG00000032242	-	95	85.849	Rhinopithecus_roxellana

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004197	cysteine-type endopeptidase activity	21873635.	IBA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	21873635.	IBA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	20228808.21239494.	IDA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	19188362.20368735.	IMP	Function
GO:0005515	protein binding	21239494.	IPI	Function
GO:0005634	nucleus	21239494.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	19188362.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006511	ubiquitin-dependent protein catabolic process	-	IEA	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0007093	mitotic cell cycle checkpoint	20228808.	IMP	Process
GO:0010955	negative regulation of protein processing	19188362.	IMP	Process
GO:0016579	protein deubiquitination	21873635.	IBA	Process
GO:0016579	protein deubiquitination	20228808.	IDA	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0030334	regulation of cell migration	21448158.	IMP	Process
GO:0031064	negative regulation of histone deacetylation	21239494.	IMP	Process
GO:0034260	negative regulation of GTPase activity	19188362.	IDA	Process
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	20228808.	IMP	Function
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	-	TAS	Function
GO:0042127	regulation of cell proliferation	19188362.	IMP	Process
GO:0042981	regulation of apoptotic process	21873635.	IBA	Process
GO:0042981	regulation of apoptotic process	21239494.	IMP	Process
GO:0043547	positive regulation of GTPase activity	21448158.	IMP	Process
GO:0050691	regulation of defense response to virus by host	20368735.	IMP	Process
GO:0070536	protein K63-linked deubiquitination	21239494.	IDA	Process
GO:0070536	protein K63-linked deubiquitination	19188362.20368735.	IMP	Process
GO:0071108	protein K48-linked deubiquitination	19188362.20368735.	IMP	Process
GO:0071586	CAAX-box protein processing	19188362.	IMP	Process
GO:0090315	negative regulation of protein targeting to membrane	19188362.	IMP	Process
GO:1900027	regulation of ruffle assembly	21448158.	IMP	Process
GO:1900245	positive regulation of MDA-5 signaling pathway	20368735.	IMP	Process
GO:1900246	positive regulation of RIG-I signaling pathway	20368735.	IMP	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.