EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25788277	HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients.	Oncotarget	2015 Mar 20	Pannu V	-
26987684	A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer.	Nat Commun	2016 Mar 18	Chavali PL	doi: 10.1038/ncomms11005.
26177331	KIFC1 is a novel potential therapeutic target for breast cancer.	Cancer Biol Ther	2015	Li Y	doi: 10.1080/15384047.2015.1070980
19190132	The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain.	Clin Cancer Res	2009 Mar 1	Grinberg-Rashi H	doi: 10.1158/1078-0432.CCR-08-2124
25028599	KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries.	J Ovarian Res	2014 May 12	Pawar S	doi: 10.1186/1757-2215-7-53
22946058	Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET.	J Cell Sci	2012 Nov 15	Kleylein-Sohn J	doi: 10.1242/jcs.107474
28964573	Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma.	Pathol Res Pract	2017 Nov	Imai T	doi: 10.1016/j.prp.2017.09.009
28218233	Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer.	Sci Rep	2017 Feb 20	Ogden A	doi: 10.1038/srep42289.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	33405269	Missense_Mutation	novel	A392T	0.42
BLCA	chr6	33406393	Silent	rs774299603	L578L	0.2
BLCA	chr6	33398298	Missense_Mutation	novel	R54T	0.26
BLCA	chr6	33403882	Missense_Mutation	NA	Q170R	0.06
BLCA	chr6	33404121	Missense_Mutation	NA	E250K	0.52
BLCA	chr6	33403862	Silent	novel	E163E	0.12
BLCA	chr6	33405180	Missense_Mutation	novel	G362A	0.12
BLCA	chr6	33405439	Silent	novel	L448L	0.5
BLCA	chr6	33403356	Missense_Mutation	novel	A98G	0.46
BLCA	chr6	33406843	Missense_Mutation	rs766822322	E649K	0.46
BLCA	chr6	33404932	Frame_Shift_Del	novel	*A280Qfs4**	0.16
BLCA	chr6	33400282	Intron	novel		0.21
BLCA	chr6	33404118	Missense_Mutation	novel	E249Q	0.22
BRCA	chr6	33406871	Missense_Mutation	NA	S658F	0.48
BRCA	chr6	33403521	Missense_Mutation	novel	V114A	0.05
BRCA	chr6	33398111	Missense_Mutation	NA	G32V	0.17
BRCA	chr6	33404875	Silent	NA	A260A	0.1
BRCA	chr6	33406862	Missense_Mutation	NA	R655H	0.1
BRCA	chr6	33391936	5'UTR	novel		0.25
BRCA	chr6	33403316	Missense_Mutation	NA	Q85E	0.12
BRCA	chr6	33405161	Missense_Mutation	rs769727957	R356W	0.15
BRCA	chr6	33403788	Silent	NA	L139L	0.35
BRCA	chr6	33403831	Missense_Mutation	NA	C153F	0.21
BRCA	chr6	33398121	Silent	novel	L35L	0.18
BRCA	chr6	33405050	Missense_Mutation	NA	P319S	0.37
BRCA	chr6	33406393	Silent	rs774299603	L578L	0.2
CESC	chr6	33391885	5'UTR	novel		0.25
CESC	chr6	33400512	Intron	novel		0.21
CESC	chr6	33391909	5'UTR	novel		0.44
CESC	chr6	33405401	Missense_Mutation	NA	R436W	0.11
CESC	chr6	33403752	Nonsense_Mutation	NA	G127*	0.38
CESC	chr6	33403753	Missense_Mutation	NA	G127E	0.37
CESC	chr6	33409771	3'UTR	novel		0.85
CESC	chr6	33398161	Missense_Mutation	novel	E49Q	0.3
CESC	chr6	33398377	Silent	NA	G80G	0.11
COAD	chr6	33400475	Intron	novel		0.22
COAD	chr6	33406218	Missense_Mutation	novel	A520G	0.47
COAD	chr6	33404028	Missense_Mutation	rs570330144	R219W	0.46
COAD	chr6	33404066	Frame_Shift_Ins	NA	*Q234Tfs52**	0.38
COAD	chr6	33406259	Missense_Mutation	rs373384743	R534W	0.36
COAD	chr6	33406269	Missense_Mutation	novel	R537H	0.16
COAD	chr6	33405474	Missense_Mutation	NA	S460I	1
COAD	chr6	33403994	Missense_Mutation	NA	K207N	0.43
COAD	chr6	33406452	Missense_Mutation	novel	T598M	0.44
COAD	chr6	33391862	5'UTR	novel		0.39
ESCA	chr6	33406418	Missense_Mutation	rs112635529	R587W	0.19
ESCA	chr6	33406454	Silent	novel	L599L	0.24
ESCA	chr6	33391977	5'UTR	novel		0.18
ESCA	chr6	33400088	Intron	novel		0.21
ESCA	chr6	33406393	Silent	rs774299603	L578L	0.35
GBM	chr6	33400554	Intron	novel		0.31
GBM	chr6	33400268	Intron	novel		0.09
GBM	chr6	33400461	Intron	novel		0.3
GBM	chr6	33400201	Intron	novel		0.17
GBM	chr6	33409702	3'UTR	novel		0.08
HNSC	chr6	33403343	Missense_Mutation	rs779398373	R94W	0.27
HNSC	chr6	33403944	Missense_Mutation	novel	H191Y	0.2
HNSC	chr6	33404111	Silent	novel	S246S	0.14
HNSC	chr6	33404016	Missense_Mutation	novel	E215Q	0.07
HNSC	chr6	33403888	Missense_Mutation	novel	R172T	0.11
HNSC	chr6	33406601	Missense_Mutation	novel	V613L	0.18
KIRC	chr6	33405202	Silent	novel	R369R	0.08
KIRC	chr6	33391916	5'UTR	novel		0.09
KIRC	chr6	33406827	Silent	novel	L643L	0.2
KIRP	chr6	33398166	Missense_Mutation	NA	K50N	0.3
KIRP	chr6	33398157	Silent	rs368144446	E47E	0.46
LAML	chr6	33398385	Missense_Mutation	novel	T83I	0.07
LGG	chr6	33403781	Silent	rs755558369	A136A	0.4
LGG	chr6	33405175	Frame_Shift_Del	novel	*S361Wfs10**	0.48
LIHC	chr6	33391737	5'UTR	novel		0.33
LIHC	chr6	33403883	Missense_Mutation	novel	Q170H	0.07
LIHC	chr6	33400496	Intron	novel		0.17
LUAD	chr6	33404914	Silent	novel	R273R	0.07
LUAD	chr6	33404915	Nonsense_Mutation	novel	Q274*	0.07
LUAD	chr6	33405434	Missense_Mutation	NA	E447Q	0.11
LUAD	chr6	33406337	Missense_Mutation	NA	P560S	0.24
LUAD	chr6	33405506	Missense_Mutation	novel	D471Y	0.13
LUAD	chr6	33405603	Missense_Mutation	NA	R503Q	0.17
LUAD	chr6	33403872	Missense_Mutation	NA	L167I	0.08
LUAD	chr6	33405244	Silent	novel	G383G	0.31
LUAD	chr6	33400070	Intron	novel		0.11
LUAD	chr6	33405114	Missense_Mutation	novel	G340V	0.16
LUAD	chr6	33406483	Silent	novel	N608N	0.12
LUAD	chr6	33403356	Missense_Mutation	novel	A98D	0.31
LUAD	chr6	33400155	Intron	novel		0.22
LUAD	chr6	33404951	Silent	rs562615563	R286R	0.1
LUAD	chr6	33406260	Missense_Mutation	novel	R534L	0.18
LUAD	chr6	33406591	Splice_Site	novel	X610_splice	0.46
LUSC	chr6	33405037	Frame_Shift_Del	novel	*V317Gfs38**	0.18
LUSC	chr6	33403520	Missense_Mutation	novel	V114I	0.08
LUSC	chr6	33391978	5'UTR	novel		0.26
LUSC	chr6	33406256	Nonsense_Mutation	novel	E533*	0.04
LUSC	chr6	33406477	Silent	novel	L606L	0.67
LUSC	chr6	33403514	Missense_Mutation	novel	V112F	0.29
MESO	chr6	33391936	5'UTR	novel		0.4
OV	chr6	33404975	Missense_Mutation	NA	E294Q	0.34
OV	chr6	33405151	Silent	novel	R352R	0.26
OV	chr6	33406470	Missense_Mutation	novel	M604K	0.1
OV	chr6	33406471	Missense_Mutation	novel	M604I	0.1
OV	chr6	33404100	Missense_Mutation	NA	G243R	0.46
OV	chr6	33403959	In_Frame_Del	novel	A197_Q201del	0.17
OV	chr6	33405544	Silent	novel	G483G	0.17
OV	chr6	33406831	Missense_Mutation	NA	E645K	0.11
OV	chr6	33409677	Frame_Shift_Ins	novel	*N671Qfs56**	0.15
OV	chr6	33405313	Silent	novel	I406I	0.07
OV	chr6	33400403	Intron	novel		0.64
OV	chr6	33391965	5'UTR	novel		0.09
OV	chr6	33403938	Nonsense_Mutation	novel	E189*	0.78
OV	chr6	33405131	Missense_Mutation	novel	T346A	0.1
PAAD	chr6	33406448	Missense_Mutation	novel	S597P	0.13
PAAD	chr6	33409815	3'UTR	novel		0.43
PAAD	chr6	33400087	Intron	novel		0.21
PRAD	chr6	33406289	Missense_Mutation	novel	L544I	0.38
READ	chr6	33405168	Missense_Mutation	novel	G358A	0.6
READ	chr6	33398033	Frame_Shift_Del	rs763606695	*L8Yfs4**	0.4
SARC	chr6	33404962	Silent	novel	R289R	0.23
SKCM	chr6	33398033	Missense_Mutation	NA	S6F	0.38
SKCM	chr6	33403828	Missense_Mutation	rs777698079	R152Q	0.44
SKCM	chr6	33400429	Intron	novel		0.22
SKCM	chr6	33405503	Missense_Mutation	rs750141338	R470W	0.54
SKCM	chr6	33406872	Silent	rs777336340	S658S	0.12
SKCM	chr6	33406823	Missense_Mutation	novel	P642L	0.29
SKCM	chr6	33405366	Missense_Mutation	rs765678209	P424L	0.23
SKCM	chr6	33405594	Missense_Mutation	novel	T500I	0.22
SKCM	chr6	33400377	Intron	NA		0.36
SKCM	chr6	33406337	Missense_Mutation	NA	P560S	0.16
SKCM	chr6	33405091	Silent	novel	L332L	0.39
SKCM	chr6	33405213	Missense_Mutation	rs765880170	S373F	0.13
SKCM	chr6	33400317	Intron	novel		0.39
SKCM	chr6	33405172	Silent	novel	T359T	0.14
SKCM	chr6	33406604	Missense_Mutation	NA	P614S	0.16
SKCM	chr6	33405062	Missense_Mutation	novel	G323R	0.88
SKCM	chr6	33405063	Missense_Mutation	rs145666693	G323E	0.88
SKCM	chr6	33403740	Missense_Mutation	NA	P123S	0.58
SKCM	chr6	33406381	Silent	rs769160369	P574P	0.69
SKCM	chr6	33398285	Splice_Region	novel		0.21
SKCM	chr6	33391993	Missense_Mutation	novel	P3L	0.23
SKCM	chr6	33403341	Missense_Mutation	novel	P93L	0.26
SKCM	chr6	33406256	Missense_Mutation	NA	E533K	0.19
SKCM	chr6	33405098	Missense_Mutation	NA	P335S	0.4
SKCM	chr6	33405267	Missense_Mutation	NA	I391T	0.84
SKCM	chr6	33405366	Missense_Mutation	rs765678209	P424L	0.39
SKCM	chr6	33400386	Intron	novel		0.21
STAD	chr6	33406335	Frame_Shift_Del	novel	*L561Sfs16**	0.2
STAD	chr6	33404002	Missense_Mutation	rs773177817	R210H	0.28
STAD	chr6	33403779	Missense_Mutation	novel	A136S	0.14
STAD	chr6	33398151	Silent	NA	G45G	0.14
STAD	chr6	33406268	Missense_Mutation	rs779218729	R537C	0.11
STAD	chr6	33405289	Silent	NA	A398A	0.14
STAD	chr6	33406221	Missense_Mutation	NA	R521L	0.44
STAD	chr6	33404994	Missense_Mutation	NA	L300R	0.18
STAD	chr6	33405580	Missense_Mutation	NA	E495D	0.3
STAD	chr6	33398345	Missense_Mutation	NA	P70A	0.41
STAD	chr6	33406264	Silent	novel	S535S	0.33
STAD	chr6	33400435	Intron	novel		0.21
UCEC	chr6	33409778	3'UTR	novel		0.41
UCEC	chr6	33404990	Nonsense_Mutation	rs140068150	R299*	0.31
UCEC	chr6	33409827	3'UTR	novel		0.2
UCEC	chr6	33409673	Nonsense_Mutation	NA	Q669*	0.37
UCEC	chr6	33400096	Intron	novel		0.21
UCEC	chr6	33404067	Frame_Shift_Del	novel	*K233Nfs12**	0.31
UCEC	chr6	33406334	Missense_Mutation	novel	A559T	0.27
UCEC	chr6	33403325	Missense_Mutation	NA	S88T	0.48
UCEC	chr6	33406833	Missense_Mutation	novel	E645D	0.04
UCEC	chr6	33405557	Missense_Mutation	novel	R488C	0.3
UCEC	chr6	33406259	Missense_Mutation	rs373384743	R534W	0.47
UCEC	chr6	33406440	Missense_Mutation	NA	S594N	0.26
UCEC	chr6	33409808	3'UTR	novel		0.15
UCEC	chr6	33406867	Missense_Mutation	NA	A657T	0.39
UCEC	chr6	33405077	Frame_Shift_Del	novel	*P329Lfs32**	0.19
UCEC	chr6	33400201	Intron	novel		0.13
UCEC	chr6	33400111	Intron	novel		0.31
UCEC	chr6	33400387	Intron	novel		0.19
UCEC	chr6	33403895	Silent	novel	A174A	0.28
UCEC	chr6	33405058	Silent	novel	L321L	0.41
UCEC	chr6	33405595	Silent	novel	T500T	0.27
UCEC	chr6	33406385	Silent	rs768629132	L576L	0.31
UCEC	chr6	33400081	Intron	novel		0.45
UCEC	chr6	33405161	Missense_Mutation	rs769727957	R356W	0.56
UCEC	chr6	33406335	Frame_Shift_Del	novel	*L561Sfs16**	0.25
UCEC	chr6	33406610	Missense_Mutation	NA	R616W	0.3
UCEC	chr6	33409847	3'UTR	novel		0.4
UCEC	chr6	33398309	Missense_Mutation	novel	A58T	0.47
UCEC	chr6	33404960	Missense_Mutation	NA	R289C	0.11
UCEC	chr6	33409858	3'UTR	NA		0.44
UCEC	chr6	33391881	5'UTR	novel		0.42
UCEC	chr6	33400275	Intron	novel		0.35
UCEC	chr6	33405329	Missense_Mutation	novel	T412A	0.43
UCEC	chr6	33400407	Intron	rs781420720		0.42
UCEC	chr6	33400542	Intron	novel		0.39
UCEC	chr6	33404028	Missense_Mutation	rs570330144	R219W	0.11
UCEC	chr6	33400532	Intron	novel		0.45
UCEC	chr6	33400278	Intron	novel		0.3
UCEC	chr6	33404977	Missense_Mutation	NA	E294D	0.28
UCEC	chr6	33406235	Missense_Mutation	novel	V526M	0.38
UCEC	chr6	33398306	Missense_Mutation	novel	G57S	0.14
UCEC	chr6	33409881	3'UTR	novel		0.31
UCEC	chr6	33400187	Intron	novel		0.45
UCEC	chr6	33406459	Silent	novel	G600G	0.61
UCEC	chr6	33400339	Intron	novel		0.28
UCEC	chr6	33404917	Missense_Mutation	novel	Q274H	0.28
UCEC	chr6	33405151	Silent	rs549983760	R352R	0.26
UCEC	chr6	33404960	Missense_Mutation	NA	R289C	0.41
UCEC	chr6	33405583	Silent	NA	E496E	0.21
UCEC	chr6	33405381	Missense_Mutation	NA	Q429R	0.31
UCEC	chr6	33400151	Intron	novel		0.4
UCEC	chr6	33404870	Nonsense_Mutation	novel	E259*	0.34
UCEC	chr6	33405134	Missense_Mutation	NA	R347C	0.29
UCS	chr6	33403834	Missense_Mutation	rs146314962	R154H	0.06

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0051	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.048	Kaplan-Meier Survival Analysis
SARC	0.004	Kaplan-Meier Survival Analysis
MESO	0.00013	Kaplan-Meier Survival Analysis
SKCM	0.0003	Kaplan-Meier Survival Analysis
PRAD	0.019	Kaplan-Meier Survival Analysis
TGCT	0.047	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.0012	Kaplan-Meier Survival Analysis
PCPG	0.035	Kaplan-Meier Survival Analysis
CESC	0.015	Kaplan-Meier Survival Analysis
READ	0.042	Kaplan-Meier Survival Analysis
KICH	0.0085	Kaplan-Meier Survival Analysis
UCEC	0.011	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.02	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.026	Kaplan-Meier Survival Analysis
LUAD	0.0016	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000237649 (Gene tree)
Gene ID: 3833
Gene Symbol: KIFC1
Alias: HSET|KNSL2
Full Name: kinesin family member C1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 18,703 bases
Position: chr6:33,391,524-33,410,226
Accession: 6389
RBP type: non-canonical RBP
Summary: (Kinesin Family Member C1) is a Protein Coding gene. Diseases associated with KIFC1 include Benign Epilepsy With Centrotemporal Spikes. Among its related pathways are Factors involved in megakaryocyte development and platelet production and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIFC3.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000428849	KIFC1-211	2706	XM_011514585	ENSP00000393963	673 (aa)	XP_011512887	Q9BW19
ENST00000450504	KIFC1-212	734	-	ENSP00000409539	203 (aa)	-	A2AB20
ENST00000494554	KIFC1-214	631	-	ENSP00000484508	154 (aa)	-	A0A087X1W5
ENST00000486695	KIFC1-213	667	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000237649's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000237649	Child Development Disorders, Pervasive	5.5000000E-005	-
ENSG00000237649	Child Development Disorders, Pervasive	5.8000000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000237649's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000070	mitotic sister chromatid segregation	8276466.	NAS	Process
GO:0003777	microtubule motor activity	21873635.	IBA	Function
GO:0003777	microtubule motor activity	8276466.	NAS	Function
GO:0005524	ATP binding	8276466.	NAS	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005769	early endosome	-	IEA	Component
GO:0005815	microtubule organizing center	-	IEA	Component
GO:0005871	kinesin complex	21873635.	IBA	Component
GO:0005874	microtubule	21873635.	IBA	Component
GO:0007018	microtubule-based movement	21873635.	IBA	Process
GO:0007080	mitotic metaphase plate congression	15843429.	IMP	Process
GO:0007283	spermatogenesis	-	IEA	Process
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0051301	cell division	-	IEA	Process
GO:0072686	mitotic spindle	21873635.	IBA	Component
GO:0090307	mitotic spindle assembly	21873635.	IBA	Process
GO:0090307	mitotic spindle assembly	15843429.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.