EuRBPDB

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24100949	Investigating a pathogenic role for TXNDC5 in tumors.	Int J Oncol	2013 Dec	Chang X	doi: 10.3892/ijo.2013.2123
20157732	The influence of TXNDC5 gene on gastric cancer cell.	J Cancer Res Clin Oncol	2010 Oct	Zhang L	doi: 10.1007/s00432-010-0807-x
25500540	The role of TXNDC5 in castration-resistant prostate cancer-involvement of androgen receptor signaling pathway.	Oncogene	2015 Sep 3	Wang L	doi: 10.1038/onc.2014.401
17895523	Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study.	Exp Biol Med (Maywood)	2007 Oct	Wang Y	-
29749460	Role of TXNDC5 in tumorigenesis of colorectal cancer cells: In vivo and in vitro evidence.	Int J Mol Med	2018 Aug	Tan F	doi: 10.3892/ijmm.2018.3664

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
COAD	chr6	7910561	Silent	novel	T72T	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1889	0.19267
CESC	DEL	0.1186	0.046699
HNSC	DEL	0.1264	0.0011062
LIHC	AMP	0.3784	1.013e-05
LUSC	DEL	0.2016	0.00029978
PAAD	DEL	0.2989	0.00010152
PRAD	DEL	0.065	0.059223
SARC	DEL	0.249	0.014376
SKCM	AMP	0.5313	6.548e-09
UVM	AMP	0.55	2.0409e-06

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0095	Kaplan-Meier Survival Analysis
MESO	0.043	Kaplan-Meier Survival Analysis
HNSC	0.017	Kaplan-Meier Survival Analysis
LUSC	0.0048	Kaplan-Meier Survival Analysis
ESCA	0.0064	Kaplan-Meier Survival Analysis
KIRP	0.0084	Kaplan-Meier Survival Analysis
BLCA	0.016	Kaplan-Meier Survival Analysis
CESC	0.0041	Kaplan-Meier Survival Analysis
READ	0.04	Kaplan-Meier Survival Analysis
LAML	0.038	Kaplan-Meier Survival Analysis
LGG	0.00082	Kaplan-Meier Survival Analysis
LUAD	0.0068	Kaplan-Meier Survival Analysis

Description

Ensembl ID: ENSG00000239264 (Gene tree)
Gene ID: 81567
Gene Symbol: TXNDC5
Alias: MGC3178|FLJ21353|FLJ90810|EndoPDI|Hcc-2|ERp46|PDIA15
Full Name: thioredoxin domain containing 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 29,565 bases
Position: chr6:7,881,250-7,910,814
Accession: 21073
RBP type: non-canonical RBP
Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000469459	TXNDC5-203	715	-	-	- (aa)	-	-
ENST00000379757	TXNDC5-201	2964	-	ENSP00000369081	432 (aa)	-	Q8NBS9
ENST00000475802	TXNDC5-205	582	-	-	- (aa)	-	-
ENST00000460138	TXNDC5-202	2704	-	-	- (aa)	-	-
ENST00000473453	TXNDC5-204	1301	-	ENSP00000420784	324 (aa)	-	Q8NBS9

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000239264	rs111331197	6	7883235	T	Blood protein levels	29875488	[1.11-1.61] unit increase	1.36	EFO_0007937
ENSG00000239264	rs182714900	6	7899503	C	Blood protein levels	30072576	[0.49-0.87] unit decrease	0.677	EFO_0007937

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000239264	TXNDC5	98	44.954	FBgn0030329	prtp	99	45.245	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	21057456.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005783	endoplasmic reticulum	16130169.	TAS	Component
GO:0005788	endoplasmic reticulum lumen	-	IEA	Component
GO:0016853	isomerase activity	-	IEA	Function
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0043202	lysosomal lumen	-	TAS	Component
GO:0043277	apoptotic cell clearance	21873635.	IBA	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045454	cell redox homeostasis	-	IEA	Process
GO:0070062	extracellular exosome	19199708.23533145.	HDA	Component