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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
16848180[Expression of CD44 and nm23-H1 protein in the primary and metastatic lymph node lesions in supraglottic and hypopharyngeal cancer].Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi2006 AprWang BS-
23158994[Significance of TIMP-1 and nm-23 expressions in HER-2-positive breast cancer].Zhonghua Zhong Liu Za Zhi2012 AugLiu Jdoi: 10.3760/cma.j.issn.0253-3766.2012.08.009.
20671611Gene expression levels of CSNK1A1 and AAC-11, but not NME1, in tumor tissues as prognostic factors in NSCLC patients.Med Sci Monit2010 AugWang Z-
15684389Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells.Mol Cell Biol2005 FebSalerno M-
16011248[Genetic instability on chromosome 17q21 in gastric cancer of Chinese patients].Shi Yan Sheng Wu Xue Bao2005 AprLin XQ-
17695492Clinical significance of nm23 gene expression in gastric cancer.Anticancer Res2007 Jul-AugMnig SP-
16531762NM-23 gene loss of heterozygosity and protein expression in high-stage laryngeal squamous cell carcinomas.Diagn Mol Pathol2006 MarSheikh H-
12910292Immunohistological study of NM 23 and C-erbB-2 expression in primary tumor and metastases of colorectal adenocarcinoma.Bull Exp Biol Med2003 MayDelektorskaya VV-
12405283Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis.Clin Exp Metastasis2002Roymans D-
25748386Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis.Cancer Lett2015 Jun 1Tong Ydoi: 10.1016/j.canlet.2015.02.050
18728402The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration.Cancer Biol Ther2008 MayMurakami M-
18470881Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1.Int J Cancer2008 Aug 1Murakami Mdoi: 10.1002/ijc.23568.
22920000The role of nm23 gene in colorectal carcinogenesis.Acta Clin Croat2012 MarTripkovi A-
24915993Interaction between Nm23 and the tumor suppressor VHL.Naunyn Schmiedebergs Arch Pharmacol2015 FebLin CHdoi: 10.1007/s00210-014-1002-4
25199839Regulation of the metastasis suppressor Nm23-H1 by tumor viruses.Naunyn Schmiedebergs Arch Pharmacol2015 FebBanerjee Sdoi: 10.1007/s00210-014-1043-8
18089805Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2.Cancer Res2007 Dec 15Horak CE-
18239814Relationship between expression of NM23 protein and clinical morphological factors and content of plasminogen activation system components in tumors of patients with gastric cancer.Bull Exp Biol Med2007 JunKushlinskii NE-
20713695Nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis.Proc Natl Acad Sci U S A2010 Aug 31Conery ARdoi: 10.1073/pnas.1010633107
27449069Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein.Naunyn Schmiedebergs Arch Pharmacol2016 NovRomani P-
16044917[Study on genetic instability of NM23H1 gene in Chinese with the epithelial ovarian tumor].Shi Yan Sheng Wu Xue Bao2005 JunYang YQ-
15882758Expression of nm23-H1 gene product in sarcomatous cancer cells of renal cell carcinoma: correlation with tumor stage and expression of matrix metalloproteinase-2, matrix metalloproteinase-9, sialyl Lewis X, and c-erbB-2.Urology2005 MayOhba K-
17975005Interaction of the tumor metastasis suppressor nonmetastatic protein 23 homologue H1 and estrogen receptor alpha alters estrogen-responsive gene expression.Cancer Res2007 Nov 1Curtis CD-
15129904Co-downregulation of PTEN, KAI-1, and nm23-H1 tumor/metastasis suppressor proteins in non-small cell lung cancer.Ann Diagn Pathol2004 FebGoncharuk VN-
12669312P53 is a regulator of the metastasis suppressor gene Nm23-H1.Mol Carcinog2003 AprChen SL-
18154714[NM23 and metastasis suppressor genes: update].Med Sci (Paris)2007 DecBoissan M-
17103045Multiple interference of the human papillomavirus-16 E7 oncoprotein with the functional role of the metastasis suppressor Nm23-H1 protein.J Bioenerg Biomembr2006 AugMileo AM-
28216015Differential regulation of NM23-H1 under hypoxic and serum starvation conditions in metastatic cancer cells and its implication in EMT.Eur J Cell Biol2017 MarRasool RUdoi: 10.1016/j.ejcb.2017.01.008
27518571Prognostic Value of NME1 (NM23-H1) in Patients with Digestive System Neoplasms: A Systematic Review and Meta-Analysis.PLoS One2016 Aug 12Han Wdoi: 10.1371/journal.pone.0160547
29700912Coexistence of MACC1 and NM23-H1 dysregulation and tumor budding promise early prognostic evidence for recurrence risk of early-stage colon cancer.APMIS2018 FebOzturk Edoi: 10.1111/apm.12801.
28831131Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression.Sci Rep2017 Aug 22Hung CYdoi: 10.1038/s41598-017-09558-7.
15334673Lymphatic metastasis and nm23H1 genetic instability in Chinese colon cancer patients.World J Gastroenterol2004 Oct 1Su ZH-
21553004Correlation of NM23-H1 cytoplasmic expression with metastatic stage in human prostate cancer tissue.Naunyn Schmiedebergs Arch Pharmacol2011 OctAndolfo Idoi: 10.1007/s00210-011-0645-7
29525404Association between NME1 polymorphisms and cancer susceptibility: A meta-analysis based on 1644 cases and 2038 controls.Pathol Res Pract2018 AprShi Xdoi: 10.1016/j.prp.2018.02.020
18668641High expression of human nonmetastatic clone 23 type 1 in cancer of uterine cervix and its association with poor cell differentiation and worse overall survival.J Surg Oncol2008 Nov 1Hsu CGdoi: 10.1002/jso.21127.
26565392NME1L Negatively Regulates IGF1-Dependent Proliferation of Breast Cancer Cells.J Cell Biochem2016 JunYou DJdoi: 10.1002/jcb.25441
27509166Polymorphism of Metastasis Suppressor Genes MKK4 and NME1 in Kashmiri Patients with Breast Cancer.Breast J2016 NovIqbal Bdoi: 10.1111/tbj.12668
12174914Correlation of MDR-1, nm23-H1 and H Sema E gene expression with histopathological findings and clinical outcome in ovarian and breast cancer patients.Anticancer Res2002 Jul-AugGalani E-
12452062[Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior].Ai Zheng2002 JunJi SQ-
14664140[Expression of nm23 and c-erbB-2 proteins in cells of primary colorectal cancer and its metastases].Arkh Patol2003 Sep-OctDelektorskaia VV-
22290468Sodium valproate inhibits MDA-MB-231 breast cancer cell migration by upregulating NM23H1 expression.Genet Mol Res2012 Jan 13Li GFdoi: 10.4238/2012.January.13.1.
23679306hMSH2 and nm23 expression in sporadic colorectal cancer and its clinical significance.Asian Pac J Cancer Prev2013Wu HW-
12883690Nm23-H1 expression does not predict clinical survival in colorectal cancer patients.Oncol Rep2003 Sep-OctDusonchet L-
23137649nm23-H1 is a negative regulator of TGF-β1-dependent induction of epithelial-mesenchymal transition.Exp Cell Res2013 Mar 10Zhao Rdoi: 10.1016/j.yexcr.2012.10.013
27592483The expression and clinical significance of metastasis suppressor gene and matrix metalloproteinase-2 in esophageal squamous cell of carcinoma.Pak J Pharm Sci2016 JulGuo XQ-
21273640The role of lipocalin 2 and its concernment with human nonmetastatic clone 23 type 1 and p53 in carcinogenesis of uterine cervix.Reprod Sci2011 MayWang PHdoi: 10.1177/1933719110395407
21080107CK5/6, EGFR, Ki-67, cyclin D1, and nm23-H1 protein expressions as predictors of pathological complete response to neoadjuvant chemotherapy in triple-negative breast cancer patients.Med Oncol2011 DecLi XRdoi: 10.1007/s12032-010-9742-6
20599259Significant association of genetic polymorphism of human nonmetastatic clone 23 type 1 gene with an increased risk of endometrial cancer.Gynecol Oncol2010 OctWang PHdoi: 10.1016/j.ygyno.2010.06.013.
18810774Relationship between nm23H1 genetic instability and clinical pathological characteristics in Chinese digestive system cancer patients.World J Gastroenterol2008 Sep 28Yang YQ-
21265090[Study on invasion and metastasis-associated genes of lung cancer related with NM23-H1 gene].Sichuan Da Xue Xue Bao Yi Xue Ban2010 NovCai CJ-
19624895[Effects of tumor metastasis suppressor gene nm23-H1 on invasion and proliferation of cervical cancer cell lines].Ai Zheng2009 JulYang Y-
23479363Composite three-marker assay for early detection of kidney cancer.Cancer Epidemiol Biomarkers Prev2013 MarSu Kim Ddoi: 10.1158/1055-9965.EPI-12-1156.
19513384Analysis of NM23 protein and components of plasminogen activation system in tumors of patients with stomach cancer with consideration for disease clinical picture and morphology.Bull Exp Biol Med2008 DecKushlinskii NE-
18676749Genetic polymorphisms of metastasis suppressor gene NME1 and breast cancer survival.Clin Cancer Res2008 Aug 1Qu Sdoi: 10.1158/1078-0432.CCR-08-0083.
17591363Correlation of nm23-H1 gene expression with clinical outcome in patients with advanced breast cancer.In Vivo2007 May-JunSgouros J-
20872186ER, PgR, HER-2, Ki-67, topoisomerase IIα, and nm23-H1 proteins expression as predictors of pathological complete response to neoadjuvant chemotherapy for locally advanced breast cancer.Med Oncol2011 DecLi XRdoi: 10.1007/s12032-010-9693-y
21442621Implication of human nonmetastatic clone 23 Type 1 and its downstream gene lipocalin 2 in metastasis and patient's survival of cancer of uterine cervix.Int J Cancer2011 Nov 15Wang PHdoi: 10.1002/ijc.25936
25321081Loss of Nm23 is associated with a more favorable tumor microenvironment in patients with breast cancer.Histol Histopathol2015 MarDur??n Edoi: 10.14670/HH-30.345
22683585nm23 gene polymorphisms are associated with survival of patients with epithelial ovarian cancer but not with susceptibility to disease.Gynecol Oncol2012 SepLi Ydoi: 10.1016/j.ygyno.2012.06.004
20559153Genetic determinants of pemetrexed responsiveness and nonresponsiveness in non-small cell lung cancer cells.J Thorac Oncol2010 AugWu MFdoi: 10.1097/JTO.0b013e3181e0b954.
16944571[Study on the correlation between the expressions of nm23H1 mRNA, VEGF-C mRNA and lymphatic metastases, survival rate with gastric cancer].Fen Zi Xi Bao Sheng Wu Xue Bao2006 FebDing GF-
18440302Alteration in gene expression profile and biological behavior in human lung cancer cell line NL9980 by nm23-H1 gene silencing.Biochem Biophys Res Commun2008 Jul 4Ma Wdoi: 10.1016/j.bbrc.2008.04.083
17688968Association of EcoRI polymorphism of the metastasis-suppressor gene NME1 with susceptibility to and severity of non-small cell lung cancer.Lung Cancer2007 NovHsieh YS-
20560137Identification of potential pharmacogenomic markers of clinical efficacy of 5-fluorouracil in colorectal cancer.Int J Cancer2011 Apr 15Nobili Sdoi: 10.1002/ijc.25514.
18330957Changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer.World J Gastroenterol2008 Mar 14Wang LB-
25373728Evidence of histidine and aspartic acid phosphorylation in human prostate cancer cells.Naunyn Schmiedebergs Arch Pharmacol2015 FebLapek JD Jrdoi: 10.1007/s00210-014-1063-4
24858271Associations of nm23H1, VEGF-C, and VEGF-3 receptor in human prostate cancer.Molecules2014 May 23Yang ZSdoi: 10.3390/molecules19056851.
15592684Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases.J Cancer Res Clin Oncol2005 MarStark AM-
15870434Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer.J Natl Cancer Inst2005 May 4Palmieri D-
12474051DNA ploidy and S-phase fraction, but not p53 or NM23-H1 expression, predict outcome in colorectal cancer patients. Result of a 5-year prospective study.J Cancer Res Clin Oncol2002 DecBazan V-
23818346Prognostic significance of estrogen receptor, progesterone receptor, HER2/neu, Ki-67, and nm23 expression in patients with invasive breast cancer.J BUON2013 Apr-JunCubukcu E-
17348207[Study on the correlationship between the expression of nm23H1mRNA, TGF-beta1mRNA and tumor metastases, survival rate with prostate cancer].Fen Zi Xi Bao Sheng Wu Xue Bao2006 DecDing GF-
22903495Associations of non-metastatic cells 1 gene polymorphisms with lymph node metastasis risk of gastric cancer in Northern Chinese population.Tumour Biol2012 DecLi ALdoi: 10.1007/s13277-012-0476-2
21913743Expression patterns of ER, HER2, and NM23-H1 in breast cancer patients with different menopausal status: correlations with metastasis.Mol Diagn Ther2011 Aug 1Dong SWdoi: 10.2165/11590360-000000000-00000.
28401162Meta-Analysis of the Relationship between NM23 Expression to Gastric Cancer Risk and Clinical Features.Biomed Res Int2017Fang Mdoi: 10.1155/2017/8047183
28376369Hepatitis C Virus E1 protein promotes cell migration and invasion by modulating cellular metastasis suppressor Nm23-H1.Virology2017 JunKhera Ldoi: 10.1016/j.virol.2017.03.014
28161101Prognostic and clinicopathological value of NM23 expression in patients with breast cancer: A systematic review and meta-analysis.Curr Probl Cancer2017 Jan - FebHan Wdoi: 10.1016/j.currproblcancer.2016.11.007
29407582NM23 downregulation and lysophosphatidic acid receptor EDG2/lpa1 upregulation during myeloid differentiation of human leukemia cells.Leuk Res2018 MarOkabe-Kado Jdoi: 10.1016/j.leukres.2018.01.003

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1751160195Intronnovel0.33
BLCAchr1751155729Silentrs372226034I25I0.07
BLCAchr1751155665Missense_MutationnovelC4Y0.33
BLCAchr1751161765Missense_MutationnovelE127Q0.26
BLCAchr17511618713'UTRrs7726735820.12
BRCAchr1751155706Missense_Mutationrs201563847R18W0.46
CESCchr1751160022Missense_MutationnovelD57Y0.53
COADchr1751159987Missense_MutationNAE45A0.36
COADchr1751155671Missense_Mutationrs549666032R6H0.32
GBMchr1751161803SilentnovelL139L0.07
GBMchr1751155671Missense_Mutationrs549666032R6H0.41
GBMchr1751159999Missense_MutationnovelK49R0.05
GBMchr1751160071Missense_MutationnovelV73A0.03
GBMchr17511620243'UTRnovel0.2
GBMchr17511618783'UTRnovel0.07
HNSCchr1751160051SilentnovelK66K0.41
LIHCchr1751155755Missense_Mutationrs765050521R34H0.24
LIHCchr1751160147Intronnovel0.46
LIHCchr1751161772Missense_MutationNAE129V0.53
LIHCchr17511619343'UTRnovel0.15
LUADchr17511619693'UTRnovel0.6
LUSCchr1751160120Intronnovel0.31
LUSCchr1751161764SilentNAA126A0.61
OVchr1751155699SilentnovelG15G0.12
PAADchr1751161777Missense_MutationnovelG131S0.17
PRADchr1751159985Silentrs751671862S44S0.16
SKCMchr1751160062Nonsense_MutationnovelS70*0.07
SKCMchr1751159980Missense_MutationnovelA43T0.04
SKCMchr1751155702SilentNAV16V0.21
SKCMchr17511619223'UTRnovel0.33
SKCMchr1751155753SilentnovelF33F0.26
STADchr1751160167Intronnovel0.19
STADchr17511620273'UTRnovel0.43
UCECchr17511618533'UTRnovel0.36
UCECchr1751155671Missense_Mutationrs549666032R6H0.34
UCECchr1751160026Missense_Mutationrs749825423R58H0.42
UCECchr1751161779Silentrs566810694G131G0.33
UCECchr1751160071Missense_MutationnovelV73A0.2
UCECchr1751161843Nonstop_MutationNA*153Rext*910.23
UCECchr1751160062Nonsense_MutationnovelS70*0.07
UCECchr1751161740SilentnovelH118H0.37
UCECchr17511620383'UTRnovel0.43
UCSchr1751159984Missense_MutationnovelS44F0.28

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.02080.18166
KIRPAMP0.66320.14801
THCADEL0.0040.221
UVMDEL0.01250.22482

Survival Analysis
CancerP-value Q-value
SARC0.023

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

ACC0.00016

Kaplan-Meier Survival Analysis

HNSC0.0061

Kaplan-Meier Survival Analysis

SKCM0.0011

Kaplan-Meier Survival Analysis

KIRP0.0017

Kaplan-Meier Survival Analysis

COAD0.016

Kaplan-Meier Survival Analysis

PAAD0.03

Kaplan-Meier Survival Analysis

PCPG0.045

Kaplan-Meier Survival Analysis

LAML0.033

Kaplan-Meier Survival Analysis

KICH0.014

Kaplan-Meier Survival Analysis

LIHC0.00021

Kaplan-Meier Survival Analysis

LGG0.032

Kaplan-Meier Survival Analysis

CHOL0.033

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

OV0.0063

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000239672 (Gene tree)
Gene ID
4830
Gene Symbol
NME1
Alias
NM23|NM23-H1|NDPKA
Full Name
NME/NM23 nucleoside diphosphate kinase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
8,893 bases
Position
chr17:51,153,536-51,162,428
Accession
7849
RBP type
non-canonical RBP
Summary
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000480143NME1-207964-ENSP00000429318139 (aa)-E7ERL0
ENST00000512768NME1-2101056--- (aa)--
ENST00000456492NME1-204510-ENSP0000038768260 (aa)-C9K028
ENST00000013034NME1-201796-ENSP00000013034177 (aa)-P15531
ENST00000511355NME1-2091645-ENSP0000042855382 (aa)-E5RHP0
ENST00000475573NME1-206781-ENSP0000043549882 (aa)-E5RHP0
ENST00000393196NME1-203940-ENSP00000376892152 (aa)-P15531
ENST00000487481NME1-208987--- (aa)--
ENST00000465188NME1-205521--- (aa)--
ENST00000336097NME1-202986-ENSP00000337060177 (aa)-P15531
Gene Model
Click here to download ENSG00000239672's gene model file
Pathways
Pathway IDPathway NameSource
hsa00230Purine metabolismKEGG
hsa00240Pyrimidine metabolismKEGG
hsa00983Drug metabolism - other enzymesKEGG
hsa01100Metabolic pathwaysKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000239672Arteries9.8350000E-005-
ENSG00000239672Platelet Function Tests2.7916848E-007-
ENSG00000239672Platelet Function Tests2.2422942E-007-
ENSG00000239672Platelet Function Tests3.7390734E-007-
ENSG00000239672Platelet Function Tests3.0885867E-007-
ENSG00000239672Platelet Function Tests2.4391370E-007-
ENSG00000239672Platelet Function Tests1.9576524E-007-
ENSG00000239672Platelet Function Tests3.2772856E-007-
ENSG00000239672Platelet Function Tests2.7029572E-007-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000239672's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000239672NME110094.079ENSMUSG00000037601Nme110096.063Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000287magnesium ion binding11555662.IDAFunction
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEAFunction
GO:0002762negative regulation of myeloid leukocyte differentiation-IEAProcess
GO:0003697single-stranded DNA binding-IEAFunction
GO:0003723RNA binding22658674.HDAFunction
GO:0004536deoxyribonuclease activity11555662.IDAFunction
GO:0004550nucleoside diphosphate kinase activity21873635.IBAFunction
GO:0004550nucleoside diphosphate kinase activity12972261.IDAFunction
GO:0005515protein binding10602478.11701125.15684389.16189514.17314099.17975005.18470881.19060904.21988832.25416956.IPIFunction
GO:0005524ATP binding12972261.IDAFunction
GO:0005525GTP binding12972261.IDAFunction
GO:0005634nucleus21630459.HDAComponent
GO:0005634nucleus16814409.IDAComponent
GO:0005634nucleus16130169.TASComponent
GO:0005737cytoplasm16130169.TASComponent
GO:0005741mitochondrial outer membrane-IEAComponent
GO:0005813centrosome-IEAComponent
GO:0005829cytosol16814409.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005882intermediate filament-IEAComponent
GO:0006165nucleoside diphosphate phosphorylation-IEAProcess
GO:0006183GTP biosynthetic process-IEAProcess
GO:0006228UTP biosynthetic process-IEAProcess
GO:0006241CTP biosynthetic process-IEAProcess
GO:0006259DNA metabolic process-IEAProcess
GO:0006897endocytosis-IEAProcess
GO:0007595lactation-IEAProcess
GO:0008285negative regulation of cell proliferation1851158.TASProcess
GO:0010629negative regulation of gene expression-IEAProcess
GO:0010976positive regulation of neuron projection development-IEAProcess
GO:0014075response to amine-IEAProcess
GO:0015949nucleobase-containing small molecule interconversion-TASProcess
GO:0016020membrane19946888.HDAComponent
GO:0019215intermediate filament binding-IEAFunction
GO:0019899enzyme binding-IEAFunction
GO:0021766hippocampus development-IEAProcess
GO:0032587ruffle membrane16814409.IDAComponent
GO:0033574response to testosterone-IEAProcess
GO:0035690cellular response to drug-IEAProcess
GO:0042802identical protein binding10602478.16189514.17314099.25416956.25910212.IPIFunction
GO:0042981regulation of apoptotic process16130169.TASProcess
GO:0043015gamma-tubulin binding-IEAFunction
GO:0043024ribosomal small subunit binding16814409.IPIFunction
GO:0043388positive regulation of DNA binding17975005.IDAProcess
GO:0048471perinuclear region of cytoplasm-IEAComponent
GO:0050679positive regulation of epithelial cell proliferation16862176.IMPProcess
GO:0051591response to cAMP-IEAProcess
GO:0070062extracellular exosome23533145.HDAComponent
GO:0071333cellular response to glucose stimulus-IEAProcess
GO:0071398cellular response to fatty acid-IEAProcess
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