EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22365962Identification of ITGB4BP as a new interaction protein of P311.Life Sci2012 Apr 20Peng Xdoi: 10.1016/j.lfs.2012.02.008
22348144The translation factor eIF6 is a Notch-dependent regulator of cell migration and invasion.PLoS One2012Benelli Ddoi: 10.1371/journal.pone.0032047
25886394EIF6 over-expression increases the motility and invasiveness of cancer cells by modulating the expression of a critical subset of membrane-bound proteins.BMC Cancer2015 Mar 15Pinzaglia Mdoi: 10.1186/s12885-015-1106-3.
21029697[Expression and significance of P311 and ITGB4BP in non-small cell lung cancer].Zhonghua Zhong Liu Za Zhi2010 JulTang CL-
25252159eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression.Biochim Biophys Acta2015 JulBrina Ddoi: 10.1016/j.bbagrm.2014.09.010
27333287Impact of a Eukaryotic Translation Initiation Factor 3a Polymorphism on Susceptibility to Gastric Cancer.Med Princ Pract2016Liu Kdoi: 10.1159/000447741
30077122Influence of eukaryotic translation initiation factor 6 on non-small cell lung cancer development and progression.Eur J Cancer2018 SepGantenbein Ndoi: 10.1016/j.ejca.2018.07.001

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2035284241Missense_MutationnovelS43Y0.45
BLCAchr2035284386SilentnovelF34F0.17
BLCAchr2035284195SilentnovelI58I0.38
BLCAchr2035284374Splice_Regionrs7636827420.45
BLCAchr2035284243SilentNAL42L0.23
BLCAchr2035284336Intronnovel0.34
BRCAchr2035280717SilentNAS102S0.2
CESCchr2035280089SilentNAL133L0.29
COADchr2035280061Missense_MutationNAA143S0.37
COADchr20352790723'UTRnovel0.21
COADchr2035279942Splice_RegionnovelV182V0.52
COADchr20352791823'UTRnovel0.29
ESCAchr2035280718Missense_MutationNAS102L0.12
GBMchr20352791403'UTRnovel0.22
GBMchr20352791193'UTRnovel0.54
HNSCchr2035279748Splice_SitenovelX183_splice0.41
HNSCchr2035279991Missense_MutationnovelS166L0.43
HNSCchr2035284327Intronnovel0.33
HNSCchr2035280718Missense_MutationNAS102L0.33
HNSCchr2035284341Intronnovel0.17
KIRCchr2035279585Missense_Mutationrs546977597R237W0.06
KIRCchr2035284245Missense_MutationNAL42V0.19
LAMLchr2035279732Nonsense_MutationnovelR188*0.03
LUADchr2035279996Missense_MutationnovelK164N0.23
LUADchr20352845655'UTRnovel0.18
LUADchr2035284333Intronnovel0.13
LUADchr2035279959Missense_MutationnovelL177V0.36
LUADchr20352791173'UTRnovel0.1
LUADchr2035284477Missense_MutationNAR4P0.13
LUADchr2035280055Nonsense_MutationNAQ145*0.72
LUSCchr20352845315'UTRnovel0.27
LUSCchr2035280718Missense_MutationNAS102L0.27
LUSCchr2035280821Missense_MutationnovelH68Y0.4
LUSCchr2035284423Missense_MutationNAT22I0.24
MESOchr20352791323'UTRnovel0.43
OVchr2035284378Splice_Regionnovel0.1
OVchr2035284253Missense_MutationnovelE39V0.51
SKCMchr2035279948SilentNAP180P0.22
SKCMchr2035284482SilentNAA2A0.28
SKCMchr2035284259Missense_MutationNAV37A0.21
STADchr2035280737Missense_Mutationrs769582164R96W0.39
STADchr2035284346Intronnovel0.7
STADchr2035284347Intronnovel0.71
STADchr20352844945'UTRnovel0.26
UCECchr2035280779Nonsense_MutationnovelQ82*0.08
UCECchr2035280655Missense_MutationNAR123M0.26
UCECchr2035280823Missense_MutationNAR67M0.16
UCECchr2035280755Missense_MutationnovelD90Y0.22
UCECchr2035280016Nonsense_Mutationrs11553027G158*0.32
UCECchr2035284317Intronnovel0.41
UCECchr20352791733'UTRrs7690450300.35
UCECchr2035280654Splice_RegionnovelR123R0.2
UCECchr2035279977Missense_Mutationrs768741006D171N0.35
UCECchr2035280818Missense_MutationNAG69S0.42
UCECchr2035280058Missense_Mutationrs144752898D144N0.42
UCECchr20352791713'UTRnovel0.3
UCECchr2035280769Missense_Mutationrs773641573R85H0.43
UCECchr2035280710Missense_MutationnovelG105S0.37
UCSchr2035279731Missense_MutationnovelR188Q0.2

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LAMLDEL0.02090.14746

Survival Analysis
CancerP-value Q-value
KIRC0.048

Kaplan-Meier Survival Analysis

SARC0.029

Kaplan-Meier Survival Analysis

MESO0.0096

Kaplan-Meier Survival Analysis

SKCM0.0015

Kaplan-Meier Survival Analysis

ESCA0.026

Kaplan-Meier Survival Analysis

PAAD0.013

Kaplan-Meier Survival Analysis

LAML0.025

Kaplan-Meier Survival Analysis

LIHC0.00015

Kaplan-Meier Survival Analysis

LGG0.011

Kaplan-Meier Survival Analysis

LUAD0.0066

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000242372 (Gene tree)
Gene ID
3692
Gene Symbol
EIF6
Alias
p27BBP|b(2)gcn|EIF3A|ITGB4BP
Full Name
eukaryotic translation initiation factor 6
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
6,080 bases
Position
chr20:35,278,906-35,284,985
Accession
6159
RBP type
non-canonical RBP
Summary
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
16006622Regulation of expression by promoters versus internal ribosome entry site in the 5'-untranslated sequence of the human cyclin-dependent kinase inhibitor p27kip1.Nucleic Acids Res2005 Jul 8Liu Z-
22279564TRBP and eIF6 homologue in Marsupenaeus japonicus play crucial roles in antiviral response.PLoS One2012Wang Sdoi: 10.1371/journal.pone.0030057
21855647Far upstream element binding protein 1 activates translation of p27Kip1 mRNA through its internal ribosomal entry site.Int J Biochem Cell Biol2011 NovZheng Ydoi: 10.1016/j.biocel.2011.08.001
25151966miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer.Oncogene2015 JunFernandez Sdoi: 10.1038/onc.2014.267
27947744-----
25639871Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer.Oncogene2016 Feb 11Seviour EGdoi: 10.1038/onc.2014.469
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000374436EIF6-2011252-ENSP00000363559245 (aa)-P56537
ENST00000374450EIF6-2031289-ENSP00000363574245 (aa)-P56537
ENST00000374443EIF6-2021017-ENSP00000363566226 (aa)-P56537
ENST00000415116EIF6-204739-ENSP00000415044186 (aa)-F8WDS6
ENST00000440766EIF6-205798-ENSP0000039590759 (aa)-F8WD20
ENST00000447927EIF6-206932-ENSP00000411450108 (aa)-A0A0B4J1Y7
ENST00000462894EIF6-208453--- (aa)--
ENST00000456600EIF6-207551-ENSP00000390897108 (aa)-B7ZBH1
Gene Model
Click here to download ENSG00000242372's gene model file
Pathways
Pathway IDPathway NameSource
hsa03008Ribosome biogenesis in eukaryotesKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000242372Iron5.2090000E-00419880490
ENSG00000242372Melanosis5E-1420585627
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000242372rs6198652035279894AFreckling20585627[NR] unit increase0.77EFO_0003963
ENSG00000242372rs24250482035284920?Sunburns30595370EFO_0003958
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000242372's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000242372EIF69970.093WBGene00001234eif-69964.490Caenorhabditis_elegans
ENSG00000242372EIF69976.636YPR016CTIF610072.245Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000054ribosomal subunit export from nucleus21873635.IBAProcess
GO:0003743translation initiation factor activity-IEAFunction
GO:0005515protein binding17507929.21665150.21903422.22365962.IPIFunction
GO:0005634nucleus12426392.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005737cytoplasm12426392.IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0006110regulation of glycolytic process-ISSProcess
GO:0006413translational initiation-IEAProcess
GO:0030687preribosome, large subunit precursor21873635.IBAComponent
GO:0032868response to insulin-ISSProcess
GO:0035195gene silencing by miRNA17507929.IMPProcess
GO:0035278miRNA mediated inhibition of translation17507929.IMPProcess
GO:0042256mature ribosome assembly21536732.IMPProcess
GO:0042273ribosomal large subunit biogenesis-IEAProcess
GO:0042304regulation of fatty acid biosynthetic process-ISSProcess
GO:0043022ribosome binding21536732.IDAFunction
GO:0043023ribosomal large subunit binding21873635.IBAFunction
GO:0045652regulation of megakaryocyte differentiation-ISSProcess
GO:0045727positive regulation of translation-ISSProcess
GO:0070062extracellular exosome19056867.23533145.HDAComponent
GO:1902626assembly of large subunit precursor of preribosome21873635.IBAProcess
GO:2000377regulation of reactive oxygen species metabolic process-ISSProcess
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