EuRBPDB

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Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
CESC	chr5	140549071	Missense_Mutation	novel	I90T	0.26	eIF_4EBP
LUAD	chr5	140548927	Missense_Mutation	rs372726703	R42Q	0.06	eIF_4EBP
OV	chr5	140548963	Missense_Mutation	NA	A54V	0.25	eIF_4EBP
SARC	chr5	140547732	5'UTR	novel		0.47
UCEC	chr5	140547742	Nonsense_Mutation	novel	S2*	0.1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	AMP	0.1076	0.069756
KIRP	DEL	0.0382	0.11554
LAML	DEL	0.089	1.2971e-07
LUSC	DEL	0.6168	0.002071
MESO	DEL	0.1494	0.20184
PRAD	AMP	0.0325	0.16448
SKCM	DEL	0.2997	2.2081e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0019	Kaplan-Meier Survival Analysis
KIRC	0.02	Kaplan-Meier Survival Analysis
SARC	0.00027	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00014	Kaplan-Meier Survival Analysis
UCS	0.047	Kaplan-Meier Survival Analysis
HNSC	0.0065	Kaplan-Meier Survival Analysis
KIRP	0.022	Kaplan-Meier Survival Analysis
PAAD	0.03	Kaplan-Meier Survival Analysis
PCPG	0.05	Kaplan-Meier Survival Analysis
GBM	0.033	Kaplan-Meier Survival Analysis
CHOL	0.0026	Kaplan-Meier Survival Analysis
LUAD	0.043	Kaplan-Meier Survival Analysis
UVM	0.0025	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000243056 (Gene tree)
Gene ID: 8637
Gene Symbol: EIF4EBP3
Alias: 4E-BP3
Full Name: eukaryotic translation initiation factor 4E binding protein 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 1,913 bases
Position: chr5:140,547,666-140,549,578
Accession: 3290
RBP type: canonical RBP
Summary: This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000308472	eIF_4EBP	PF05456.11	1.4e-37	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000310331	EIF4EBP3-201	691	-	ENSP00000308472	100 (aa)	-	O60516

Gene Model

Click here to download ENSG00000243056's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000243056's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000243056	EIF4EBP3	100	66.964	ENSAPOG00000010355	eif4ebp3l	100	65.179	Acanthochromis_polyacanthus
ENSG00000243056	EIF4EBP3	100	66.964	ENSAOCG00000007351	eif4ebp3l	100	65.179	Amphiprion_ocellaris
ENSG00000243056	EIF4EBP3	100	66.964	ENSAPEG00000010500	eif4ebp3l	100	65.179	Amphiprion_percula
ENSG00000243056	EIF4EBP3	100	66.071	ENSATEG00000000149	eif4ebp3l	100	64.286	Anabas_testudineus
ENSG00000243056	EIF4EBP3	86	75.000	ENSACLG00000025145	eif4ebp3l	79	72.727	Astatotilapia_calliptera
ENSG00000243056	EIF4EBP3	97	62.136	ENSAMXG00000007416	eif4ebp3	94	61.165	Astyanax_mexicanus
ENSG00000243056	EIF4EBP3	100	61.607	ENSAMXG00000042158	eif4ebp3l	100	66.964	Astyanax_mexicanus
ENSG00000243056	EIF4EBP3	76	85.714	ENSBTAG00000052310	EIF4EBP3	74	81.818	Bos_taurus
ENSG00000243056	EIF4EBP3	100	99.000	ENSCJAG00000041408	EIF4EBP3	100	99.000	Callithrix_jacchus
ENSG00000243056	EIF4EBP3	100	98.000	ENSCAFG00020001947	EIF4EBP3	100	98.000	Canis_lupus_dingo
ENSG00000243056	EIF4EBP3	87	79.348	ENSCHIG00000026608	EIF4EBP3	90	76.087	Capra_hircus
ENSG00000243056	EIF4EBP3	100	88.000	ENSTSYG00000028184	EIF4EBP3	100	88.000	Carlito_syrichta
ENSG00000243056	EIF4EBP3	100	90.099	ENSCPOG00000033979	EIF4EBP3	100	86.139	Cavia_porcellus
ENSG00000243056	EIF4EBP3	100	88.119	ENSCLAG00000003391	EIF4EBP3	100	84.158	Chinchilla_lanigera
ENSG00000243056	EIF4EBP3	100	97.000	ENSCSAG00000012830	EIF4EBP3	100	97.000	Chlorocebus_sabaeus
ENSG00000243056	EIF4EBP3	99	80.198	ENSCPBG00000007581	EIF4EBP3	96	76.238	Chrysemys_picta_bellii
ENSG00000243056	EIF4EBP3	99	98.990	ENSCANG00000036245	EIF4EBP3	100	98.990	Colobus_angolensis_palliatus
ENSG00000243056	EIF4EBP3	100	86.139	ENSCGRG00001014184	Eif4ebp3	100	82.178	Cricetulus_griseus_chok1gshd
ENSG00000243056	EIF4EBP3	100	86.139	ENSCGRG00000006941	Eif4ebp3	100	82.178	Cricetulus_griseus_crigri
ENSG00000243056	EIF4EBP3	100	63.393	ENSCSEG00000018681	eif4ebp3l	100	63.393	Cynoglossus_semilaevis
ENSG00000243056	EIF4EBP3	95	66.667	ENSCVAG00000021288	eif4ebp3l	92	64.762	Cyprinodon_variegatus
ENSG00000243056	EIF4EBP3	97	57.692	ENSDARG00000054916	eif4ebp3	94	58.252	Danio_rerio
ENSG00000243056	EIF4EBP3	100	63.393	ENSDARG00000041607	eif4ebp3l	100	65.179	Danio_rerio
ENSG00000243056	EIF4EBP3	100	91.089	ENSDORG00000024746	Eif4ebp3	100	87.129	Dipodomys_ordii
ENSG00000243056	EIF4EBP3	100	94.059	ENSEASG00005017482	EIF4EBP3	100	90.099	Equus_asinus_asinus
ENSG00000243056	EIF4EBP3	100	93.069	ENSECAG00000034514	EIF4EBP3	100	89.109	Equus_caballus
ENSG00000243056	EIF4EBP3	95	67.647	ENSELUG00000006596	eif4ebp3l	92	71.569	Esox_lucius
ENSG00000243056	EIF4EBP3	95	64.356	ENSELUG00000021245	eif4ebp3	94	63.366	Esox_lucius
ENSG00000243056	EIF4EBP3	100	97.030	ENSFCAG00000044383	EIF4EBP3	100	97.030	Felis_catus
ENSG00000243056	EIF4EBP3	100	93.069	ENSFDAG00000013042	EIF4EBP3	100	91.089	Fukomys_damarensis
ENSG00000243056	EIF4EBP3	100	64.035	ENSFHEG00000001957	eif4ebp3l	100	62.281	Fundulus_heteroclitus
ENSG00000243056	EIF4EBP3	100	68.182	ENSGMOG00000003122	eif4ebp3l	96	65.421	Gadus_morhua
ENSG00000243056	EIF4EBP3	67	70.588	ENSGALG00000048830	EIF4EBP3	55	64.706	Gallus_gallus
ENSG00000243056	EIF4EBP3	82	67.021	ENSGAFG00000002815	eif4ebp3l	75	74.667	Gambusia_affinis
ENSG00000243056	EIF4EBP3	100	66.964	ENSGACG00000018498	eif4ebp3l	98	65.179	Gasterosteus_aculeatus
ENSG00000243056	EIF4EBP3	86	75.000	ENSHBUG00000003021	eif4ebp3l	79	72.727	Haplochromis_burtoni
ENSG00000243056	EIF4EBP3	100	95.050	ENSHGLG00000008728	EIF4EBP3	100	91.089	Heterocephalus_glaber_female
ENSG00000243056	EIF4EBP3	100	95.050	ENSHGLG00100006719	EIF4EBP3	100	91.089	Heterocephalus_glaber_male
ENSG00000243056	EIF4EBP3	100	65.455	ENSHCOG00000003055	eif4ebp3l	100	65.455	Hippocampus_comes
ENSG00000243056	EIF4EBP3	100	63.393	ENSIPUG00000018246	4eb3l	100	70.536	Ictalurus_punctatus
ENSG00000243056	EIF4EBP3	98	61.321	ENSIPUG00000020570	eif4ebp3l	94	60.952	Ictalurus_punctatus
ENSG00000243056	EIF4EBP3	100	92.079	ENSSTOG00000020350	EIF4EBP3	100	88.119	Ictidomys_tridecemlineatus
ENSG00000243056	EIF4EBP3	100	92.079	ENSJJAG00000016625	Eif4ebp3	100	84.000	Jaculus_jaculus
ENSG00000243056	EIF4EBP3	100	67.257	ENSKMAG00000016697	eif4ebp3l	100	66.372	Kryptolebias_marmoratus
ENSG00000243056	EIF4EBP3	95	67.961	ENSLBEG00000014223	eif4ebp3l	92	66.990	Labrus_bergylta
ENSG00000243056	EIF4EBP3	100	72.897	ENSLACG00000016472	EIF4EBP3	96	71.963	Latimeria_chalumnae
ENSG00000243056	EIF4EBP3	80	74.419	ENSLOCG00000012500	eif4ebp3l	89	74.074	Lepisosteus_oculatus
ENSG00000243056	EIF4EBP3	100	66.071	ENSMAMG00000013532	eif4ebp3l	100	64.286	Mastacembelus_armatus
ENSG00000243056	EIF4EBP3	86	75.000	ENSMZEG00005007636	eif4ebp3l	79	72.727	Maylandia_zebra
ENSG00000243056	EIF4EBP3	100	85.149	ENSMAUG00000015124	Eif4ebp3	100	81.188	Mesocricetus_auratus
ENSG00000243056	EIF4EBP3	100	80.198	ENSMOCG00000021408	Eif4ebp3	100	74.000	Microtus_ochrogaster
ENSG00000243056	EIF4EBP3	99	66.355	ENSMMOG00000009467	eif4ebp3l	96	64.486	Mola_mola
ENSG00000243056	EIF4EBP3	100	66.071	ENSMALG00000006261	eif4ebp3l	100	65.179	Monopterus_albus
ENSG00000243056	EIF4EBP3	100	87.129	MGP_CAROLIEiJ_G0022128	Eif4ebp3	100	83.168	Mus_caroli
ENSG00000243056	EIF4EBP3	100	86.139	ENSMUSG00000090264	Eif4ebp3	100	82.178	Mus_musculus
ENSG00000243056	EIF4EBP3	100	87.129	MGP_PahariEiJ_G0018862	Eif4ebp3	100	83.168	Mus_pahari
ENSG00000243056	EIF4EBP3	100	87.129	MGP_SPRETEiJ_G0023040	Eif4ebp3	100	83.168	Mus_spretus
ENSG00000243056	EIF4EBP3	100	83.168	ENSNGAG00000016353	Eif4ebp3	100	85.149	Nannospalax_galili
ENSG00000243056	EIF4EBP3	100	92.079	ENSODEG00000004026	EIF4EBP3	100	88.119	Octodon_degus
ENSG00000243056	EIF4EBP3	86	75.000	ENSONIG00000017571	eif4ebp3l	79	72.727	Oreochromis_niloticus
ENSG00000243056	EIF4EBP3	73	86.486	ENSOANG00000001494	EIF4EBP3	100	81.081	Ornithorhynchus_anatinus
ENSG00000243056	EIF4EBP3	97	68.932	ENSORLG00000024341	eif4ebp3l	94	66.019	Oryzias_latipes
ENSG00000243056	EIF4EBP3	97	68.932	ENSORLG00020004753	eif4ebp3l	94	66.019	Oryzias_latipes_hni
ENSG00000243056	EIF4EBP3	97	68.932	ENSORLG00015008086	eif4ebp3l	94	66.019	Oryzias_latipes_hsok
ENSG00000243056	EIF4EBP3	97	68.932	ENSOMEG00000013335	eif4ebp3l	94	67.961	Oryzias_melastigma
ENSG00000243056	EIF4EBP3	100	96.040	ENSPPRG00000023846	EIF4EBP3	100	96.040	Panthera_pardus
ENSG00000243056	EIF4EBP3	100	97.030	ENSPTIG00000010875	EIF4EBP3	100	97.030	Panthera_tigris_altaica
ENSG00000243056	EIF4EBP3	70	72.368	ENSPKIG00000005779	eif4ebp3	60	68.675	Paramormyrops_kingsleyae
ENSG00000243056	EIF4EBP3	86	77.011	ENSPMGG00000000673	eif4ebp3l	75	79.310	Periophthalmus_magnuspinnatus
ENSG00000243056	EIF4EBP3	100	79.000	ENSPCIG00000017473	EIF4EBP3	100	79.000	Phascolarctos_cinereus
ENSG00000243056	EIF4EBP3	100	64.912	ENSPFOG00000007698	eif4ebp3l	100	63.158	Poecilia_formosa
ENSG00000243056	EIF4EBP3	82	67.021	ENSPLAG00000002047	eif4ebp3l	74	71.951	Poecilia_latipinna
ENSG00000243056	EIF4EBP3	100	64.912	ENSPMEG00000008305	eif4ebp3l	100	63.158	Poecilia_mexicana
ENSG00000243056	EIF4EBP3	100	97.030	ENSPCOG00000014289	EIF4EBP3	100	97.030	Propithecus_coquereli
ENSG00000243056	EIF4EBP3	99	63.810	ENSPNAG00000007774	eif4ebp3l	90	66.000	Pygocentrus_nattereri
ENSG00000243056	EIF4EBP3	98	59.615	ENSPNAG00000011458	eif4ebp3	95	59.048	Pygocentrus_nattereri
ENSG00000243056	EIF4EBP3	87	68.539	ENSSFOG00015016325	eif4ebp3l	94	76.404	Scleropages_formosus
ENSG00000243056	EIF4EBP3	97	67.619	ENSSMAG00000010258	eif4ebp3l	95	66.667	Scophthalmus_maximus
ENSG00000243056	EIF4EBP3	100	66.964	ENSSDUG00000011012	eif4ebp3l	100	65.179	Seriola_dumerili
ENSG00000243056	EIF4EBP3	100	66.964	ENSSLDG00000002841	eif4ebp3l	100	65.179	Seriola_lalandi_dorsalis
ENSG00000243056	EIF4EBP3	100	66.964	ENSSPAG00000015188	eif4ebp3l	100	65.179	Stegastes_partitus
ENSG00000243056	EIF4EBP3	100	93.069	ENSSSCG00000020835	EIF4EBP3	100	92.079	Sus_scrofa
ENSG00000243056	EIF4EBP3	95	67.961	ENSTRUG00000002444	eif4ebp3l	92	66.019	Takifugu_rubripes
ENSG00000243056	EIF4EBP3	95	66.990	ENSTNIG00000015789	eif4ebp3l	91	66.019	Tetraodon_nigroviridis
ENSG00000243056	EIF4EBP3	100	97.030	ENSUAMG00000005352	EIF4EBP3	100	97.030	Ursus_americanus
ENSG00000243056	EIF4EBP3	100	97.030	ENSUMAG00000013279	EIF4EBP3	100	97.030	Ursus_maritimus
ENSG00000243056	EIF4EBP3	100	96.040	ENSVVUG00000012362	-	100	96.040	Vulpes_vulpes
ENSG00000243056	EIF4EBP3	95	64.583	ENSVVUG00000015501	-	62	81.250	Vulpes_vulpes
ENSG00000243056	EIF4EBP3	100	64.912	ENSXCOG00000011168	eif4ebp3l	100	63.158	Xiphophorus_couchianus
ENSG00000243056	EIF4EBP3	100	64.912	ENSXMAG00000029844	eif4ebp3l	100	63.158	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	15153109.16271312.22684010.25416956.	IPI	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0008190	eukaryotic initiation factor 4E binding	21873635.	IBA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016281	eukaryotic translation initiation factor 4F complex	9593750.	NAS	Component
GO:0030371	translation repressor activity	9593750.	NAS	Function
GO:0045947	negative regulation of translational initiation	21873635.	IBA	Process
GO:0045947	negative regulation of translational initiation	9593750.	NAS	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.