EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27153830	Human dipeptidyl peptidase III mRNA variant I and II are expressed concurrently in multiple tumor derived cell lines and translated at comparable efficiency in vitro.	Mol Biol Rep	2016 Jun	Prajapati SC	doi: 10.1007/s11033-016-3996-9

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr11	66504628	Missense_Mutation	novel	G632E	0.39
BLCA	chr11	66491542	Missense_Mutation	NA	E283K	0.39
BLCA	chr11	66504690	Missense_Mutation	NA	E653K	0.3
BLCA	chr11	66509096	Missense_Mutation	novel	L687V	0.12
BLCA	chr11	66495230	Missense_Mutation	NA	D472N	0.41
BLCA	chr11	66491585	Missense_Mutation	NA	S297F	0.22
BLCA	chr11	66504756	Missense_Mutation	novel	P675A	0.08
BLCA	chr11	66504707	Silent	NA	L658L	0.2
BRCA	chr11	66485179	Missense_Mutation	novel	L93M	0.11
BRCA	chr11	66497475	Missense_Mutation	novel	Q626E	0.15
BRCA	chr11	66497476	Missense_Mutation	novel	Q626R	0.15
BRCA	chr11	66509118	Missense_Mutation	NA	A694D	0.2
BRCA	chr11	66509145	Missense_Mutation	rs775773853	R703H	0.55
BRCA	chr11	66497353	Missense_Mutation	NA	G585E	0.62
CESC	chr11	66482330	Missense_Mutation	novel	G44R	0.23
CESC	chr11	66497314	Missense_Mutation	rs777823683	R572Q	0.39
CESC	chr11	66487936	Missense_Mutation	rs778551062	R199Q	0.33
CESC	chr11	66497475	Nonsense_Mutation	NA	Q626*	0.16
CESC	chr11	66509326	3'UTR	NA		0.25
CESC	chr11	66509513	3'UTR	novel		0.3
CESC	chr11	66493086	Silent	rs147519149	T401T	0.41
CHOL	chr11	66491287	Silent	novel	L234L	0.1
COAD	chr11	66509231	Missense_Mutation	novel	A732T	0.12
COAD	chr11	66486619	Missense_Mutation	NA	C147Y	0.47
COAD	chr11	66482298	Missense_Mutation	rs756979162	Y33C	0.2
COAD	chr11	66493124	Missense_Mutation	NA	A414V	0.2
COAD	chr11	66495440	Missense_Mutation	rs766673185	R510W	0.4
COAD	chr11	66491546	Missense_Mutation	NA	S284N	0.31
COAD	chr11	66485237	Missense_Mutation	novel	T112I	0.34
COAD	chr11	66486655	Missense_Mutation	rs755183144	R159Q	0.37
COAD	chr11	66482390	Missense_Mutation	NA	S64G	0.57
COAD	chr11	66504683	Frame_Shift_Ins	rs772006461	*E653Rfs14**	0.45
COAD	chr11	66495440	Missense_Mutation	rs766673185	R510W	0.45
ESCA	chr11	66509386	3'UTR	novel		0.25
ESCA	chr11	66482357	Missense_Mutation	novel	S53P	0.48
GBM	chr11	66482452	Silent	novel	L84L	0.12
GBM	chr11	66509109	Missense_Mutation	novel	A691V	0.41
HNSC	chr11	66504765	Missense_Mutation	rs199617262	R678C	0.15
HNSC	chr11	66495410	Missense_Mutation	rs201439382	S500C	0.25
HNSC	chr11	66492906	Silent	rs202241881	P393P	0.25
HNSC	chr11	66495389	Missense_Mutation	novel	E493Q	0.13
HNSC	chr11	66504726	Missense_Mutation	rs200243081	R665C	0.19
HNSC	chr11	66509137	Missense_Mutation	novel	F700L	0.13
HNSC	chr11	66493102	Missense_Mutation	novel	V407M	0.13
KIRC	chr11	66495219	Missense_Mutation	NA	A468V	0.3
KIRC	chr11	66488000	Silent	NA	L220L	0.11
KIRP	chr11	66492771	Silent	rs200674271	A348A	0.43
KIRP	chr11	66504726	Missense_Mutation	rs200243081	R665C	0.08
LAML	chr11	66482329	Silent	rs200614411	Y43Y	0.42
LAML	chr11	66487322	Nonsense_Mutation	novel	Q185*	0.34
LGG	chr11	66509149	Silent	novel	F704F	0.39
LIHC	chr11	66497295	Splice_Region	rs755257218		0.33
LIHC	chr11	66491269	Silent	NA	S228S	0.44
LIHC	chr11	66491559	Silent	rs781635422	G288G	0.42
LIHC	chr11	66482441	Missense_Mutation	NA	A81S	0.1
LIHC	chr11	66482441	Missense_Mutation	NA	A81S	0.11
LUAD	chr11	66497325	Silent	rs567600069	L576L	0.27
LUAD	chr11	66495709	Missense_Mutation	novel	A553T	0.12
LUAD	chr11	66491339	Missense_Mutation	NA	A252P	0.16
LUAD	chr11	66509108	Missense_Mutation	novel	A691S	0.09
LUAD	chr11	66491327	Silent	NA	R248R	0.24
LUAD	chr11	66504642	Missense_Mutation	NA	G637R	0.11
LUAD	chr11	66495260	Missense_Mutation	novel	G482C	0.23
LUAD	chr11	66509144	Missense_Mutation	rs201013550	R703C	0.11
LUAD	chr11	66504668	Silent	NA	A645A	0.19
LUAD	chr11	66491372	Nonsense_Mutation	novel	E263*	0.42
LUAD	chr11	66495363	Splice_Site	novel	X485_splice	0.65
LUAD	chr11	66509078	Splice_Site	NA	X681_splice	0.12
LUSC	chr11	66493617	Missense_Mutation	novel	G458V	0.22
LUSC	chr11	66482329	Silent	rs200614411	Y43Y	0.5
LUSC	chr11	66486560	Silent	NA	I127I	0.15
LUSC	chr11	66492851	Missense_Mutation	NA	S375F	0.13
LUSC	chr11	66487989	Missense_Mutation	novel	A217T	0.12
LUSC	chr11	66504627	Missense_Mutation	novel	G632W	0.24
LUSC	chr11	66482280	Missense_Mutation	rs199921998	S27L	0.25
OV	chr11	66504770	Silent	NA	L679L	0.52
OV	chr11	66482262	Missense_Mutation	novel	E21V	0.15
OV	chr11	66492872	Missense_Mutation	NA	A382D	0.19
OV	chr11	66491372	Missense_Mutation	NA	E263K	0.18
OV	chr11	66492805	Missense_Mutation	novel	P360S	0.27
PAAD	chr11	66487325	Missense_Mutation	novel	D186N	0.17
PAAD	chr11	66487917	Missense_Mutation	novel	L193I	0.2
PAAD	chr11	66491725	Silent	rs201030149	R319R	0.19
PRAD	chr11	66492773	Missense_Mutation	NA	S349N	0.16
READ	chr11	66491308	Silent	novel	G241G	0.27
READ	chr11	66482238	Missense_Mutation	NA	G13D	0.34
READ	chr11	66492828	Missense_Mutation	novel	K367N	0.31
READ	chr11	66504656	Silent	rs756177410	Y641Y	0.38
SARC	chr11	66482356	In_Frame_Del	novel	S53_S64del	0.37
SARC	chr11	66509334	3'UTR	novel		0.41
SKCM	chr11	66492834	Silent	novel	L369L	0.33
SKCM	chr11	66497371	Missense_Mutation	NA	P591L	0.24
SKCM	chr11	66495694	Missense_Mutation	rs535853041	R548W	0.27
SKCM	chr11	66487312	Silent	NA	A181A	0.28
SKCM	chr11	66491255	Missense_Mutation	rs756886888	P224S	0.08
SKCM	chr11	66491730	Missense_Mutation	NA	P321L	0.29
SKCM	chr11	66482314	Silent	NA	S38S	0.4
SKCM	chr11	66486606	Missense_Mutation	NA	L143F	0.32
SKCM	chr11	66482236	Silent	rs199628557	I12I	0.3
SKCM	chr11	66509228	Missense_Mutation	rs775789213	E731K	0.29
SKCM	chr11	66495454	Silent	novel	V514V	0.32
SKCM	chr11	66493141	Frame_Shift_Del	novel	*Q420Sfs57**	0.21
SKCM	chr11	66492905	Missense_Mutation	NA	P393L	0.12
SKCM	chr11	66491275	Silent	NA	V230V	0.47
SKCM	chr11	66482358	Missense_Mutation	NA	S53F	0.28
SKCM	chr11	66504746	Silent	rs767272417	L671L	0.61
SKCM	chr11	66491304	Missense_Mutation	NA	R240P	0.23
SKCM	chr11	66495251	Missense_Mutation	novel	P479S	0.26
SKCM	chr11	66497384	Silent	novel	S595S	0.21
SKCM	chr11	66486654	Nonsense_Mutation	rs749706093	R159*	0.23
SKCM	chr11	66497301	Missense_Mutation	novel	H568Y	0.22
STAD	chr11	66495451	Silent	rs199807328	S513S	0.29
STAD	chr11	66482313	Missense_Mutation	NA	S38F	0.15
STAD	chr11	66492721	Missense_Mutation	rs200473591	V332I	0.28
STAD	chr11	66482270	Missense_Mutation	rs201658473	R24C	0.33
STAD	chr11	66509086	Silent	rs748963611	D683D	0.42
STAD	chr11	66482382	Missense_Mutation	novel	A61D	0.08
STAD	chr11	66495385	Frame_Shift_Ins	novel	*E493Gfs5**	0.11
STAD	chr11	66491334	Missense_Mutation	NA	D250G	0.32
STAD	chr11	66495451	Silent	rs199807328	S513S	0.21
STAD	chr11	66487977	Missense_Mutation	rs201608803	E213K	0.09
STAD	chr11	66492813	Silent	NA	T362T	0.26
STAD	chr11	66495664	Missense_Mutation	NA	V538M	0.32
STAD	chr11	66492781	Nonsense_Mutation	NA	Q352*	0.43
STAD	chr11	66485192	Missense_Mutation	rs202120263	A97V	0.18
STAD	chr11	66504660	Missense_Mutation	novel	G643W	0.35
STAD	chr11	66491522	Missense_Mutation	NA	Q276R	0.28
STAD	chr11	66497457	Missense_Mutation	rs201663539	R620C	0.47
TGCT	chr11	66509112	Frame_Shift_Del	novel	S692*	0.4
TGCT	chr11	66509113	Silent	novel	S692S	0.42
TGCT	chr11	66492804	Nonsense_Mutation	novel	W359*	0.78
THCA	chr11	66495666	Silent	NA	V538V	0.16
THCA	chr11	66497353	Missense_Mutation	NA	G585A	0.37
UCEC	chr11	66491493	Splice_Site	novel	X267_splice	0.32
UCEC	chr11	66491328	Missense_Mutation	rs772573325	R248Q	0.45
UCEC	chr11	66486552	Missense_Mutation	rs145463220	R125W	0.35
UCEC	chr11	66495387	Missense_Mutation	novel	G492E	0.35
UCEC	chr11	66492892	Missense_Mutation	novel	G389C	0.38
UCEC	chr11	66493135	Missense_Mutation	rs369300185	A418T	0.41
UCEC	chr11	66491588	Missense_Mutation	rs201367893	R298H	0.39
UCEC	chr11	66482339	Missense_Mutation	novel	A47T	0.56
UCEC	chr11	66482288	Nonsense_Mutation	novel	E30*	0.48
UCEC	chr11	66495451	Silent	rs199807328	S513S	0.46
UCEC	chr11	66486654	Nonsense_Mutation	rs749706093	R159*	0.36
UCEC	chr11	66497357	Silent	NA	L586L	0.38
UCEC	chr11	66504727	Missense_Mutation	rs139251036	R665H	0.15
UCEC	chr11	66495720	Missense_Mutation	NA	F556L	0.36
UCEC	chr11	66509521	3'UTR	novel		0.35
UCEC	chr11	66486603	Missense_Mutation	novel	G142S	0.41
UCEC	chr11	66497466	Missense_Mutation	novel	R623W	0.38
UCEC	chr11	66486594	Nonsense_Mutation	novel	E139*	0.54
UCEC	chr11	66492824	Missense_Mutation	novel	D366G	0.07
UCEC	chr11	66482436	Missense_Mutation	novel	A79V	0.26
UCEC	chr11	66495694	Missense_Mutation	rs535853041	R548W	0.42
UCEC	chr11	66486620	Silent	rs371913309	C147C	0.42
UCEC	chr11	66495427	Silent	NA	S505S	0.45
UCEC	chr11	66482258	Missense_Mutation	rs200657045	R20C	0.38
UCEC	chr11	66497357	Silent	NA	L586L	0.41
UCEC	chr11	66491565	Silent	rs200467563	I290I	0.27
UCEC	chr11	66495208	Splice_Region	rs560168052	D464D	0.28
UCEC	chr11	66482236	Silent	rs199628557	I12I	0.22
UCEC	chr11	66495268	Missense_Mutation	novel	Q484H	0.33
UCEC	chr11	66509471	3'UTR	novel		0.15
UCEC	chr11	66491741	Nonsense_Mutation	rs375500772	R325*	0.44
UCEC	chr11	66509104	Silent	novel	Y689Y	0.29
UCEC	chr11	66491747	Nonsense_Mutation	NA	E327*	0.42
UCEC	chr11	66495262	Silent	rs755015820	G482G	0.27
UCEC	chr11	66493594	Silent	rs200308709	H450H	0.51
UCEC	chr11	66482206	Silent	rs139875519	A2A	0.13
UCEC	chr11	66491503	Missense_Mutation	novel	A270T	0.13
UCEC	chr11	66492870	Silent	rs371574227	F381F	0.36
UCEC	chr11	66485178	Silent	novel	F92F	0.45
UCEC	chr11	66491704	Silent	novel	I312I	0.42
UCEC	chr11	66504726	Missense_Mutation	rs200243081	R665C	0.54
UCS	chr11	66491704	Silent	novel	I312I	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.25	0.018342
TGCT	DEL	0.6933	0.21504

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0098	Kaplan-Meier Survival Analysis
STAD	0.00016	Kaplan-Meier Survival Analysis
HNSC	0.011	Kaplan-Meier Survival Analysis
COAD	0.017	Kaplan-Meier Survival Analysis
PAAD	0.0054	Kaplan-Meier Survival Analysis
PCPG	0.012	Kaplan-Meier Survival Analysis
CESC	0.027	Kaplan-Meier Survival Analysis
LAML	0.00013	Kaplan-Meier Survival Analysis
KICH	0.015	Kaplan-Meier Survival Analysis
LIHC	0.00031	Kaplan-Meier Survival Analysis
LGG	0.006	Kaplan-Meier Survival Analysis
CHOL	0.023	Kaplan-Meier Survival Analysis
LUAD	0.0068	Kaplan-Meier Survival Analysis
UVM	0.042	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000254986 (Gene tree)
Gene ID: 10072
Gene Symbol: DPP3
Alias: N
Full Name: dipeptidyl peptidase 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 29,647 bases
Position: chr11:66,480,013-66,509,659
Accession: 3008
RBP type: non-canonical RBP
Summary: This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000544603	DPP3-216	566	-	-	- (aa)	-	-
ENST00000533725	DPP3-212	595	-	ENSP00000434518	177 (aa)	-	E9PQ14
ENST00000525738	DPP3-201	463	-	-	- (aa)	-	-
ENST00000539085	DPP3-214	391	-	-	- (aa)	-	-
ENST00000526515	DPP3-203	547	-	ENSP00000431606	170 (aa)	-	E9PKK8
ENST00000531863	DPP3-209	2974	-	ENSP00000432782	757 (aa)	-	G3V180
ENST00000532677	DPP3-211	3078	-	ENSP00000435284	756 (aa)	-	G3V1D3
ENST00000532019	DPP3-210	561	-	ENSP00000437101	104 (aa)	-	E9PNX5
ENST00000531272	DPP3-206	572	-	-	- (aa)	-	-
ENST00000533799	DPP3-213	617	-	-	- (aa)	-	-
ENST00000531354	DPP3-208	733	-	ENSP00000432618	201 (aa)	-	E9PPK9
ENST00000541961	DPP3-215	2676	-	ENSP00000440502	737 (aa)	-	Q9NY33
ENST00000531314	DPP3-207	563	-	ENSP00000436820	90 (aa)	-	E9PQF2
ENST00000526250	DPP3-202	737	-	-	- (aa)	-	-
ENST00000526667	DPP3-204	832	-	-	- (aa)	-	-
ENST00000530165	DPP3-205	2251	-	ENSP00000436941	707 (aa)	-	Q9NY33

Gene Model

Click here to download ENSG00000254986's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000254986	Platelet Function Tests	1.3600000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000254986's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	19615732.21516116.25416956.	IPI	Function
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006508	proteolysis	9425109.10387075.	IDA	Process
GO:0008237	metallopeptidase activity	-	IEA	Function
GO:0008239	dipeptidyl-peptidase activity	21873635.	IBA	Function
GO:0008239	dipeptidyl-peptidase activity	9425109.10387075.	IDA	Function
GO:0008270	zinc ion binding	9425109.10387075.	IDA	Function
GO:0016607	nuclear speck	-	IDA	Component
GO:0070062	extracellular exosome	20458337.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.