EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
LGG	chr17	81707021	Missense_Mutation	NA	Q154R	0.14	Ribosomal_L12
PRAD	chr17	81707364	3'UTR	novel		0.67
SKCM	chr17	81707034	Silent	rs762149015	L158L	0.33
SKCM	chr17	81707376	3'UTR	novel		0.55
STAD	chr17	81707225	Silent	rs201467196	T194T	0.21
UCEC	chr17	81707034	Silent	rs762149015	L158L	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3873	0.00012456
CESC	DEL	0.1085	0.00067839
KIRP	AMP	0.6701	0.14801
LGG	AMP	0.0721	1.52e-05
SARC	AMP	0.2023	0.032181
SKCM	AMP	0.2834	7.0388e-08
THCA	DEL	0.002	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.05	Kaplan-Meier Survival Analysis
ACC	0.027	Kaplan-Meier Survival Analysis
SKCM	0.0042	Kaplan-Meier Survival Analysis
ESCA	0.026	Kaplan-Meier Survival Analysis
COAD	0.03	Kaplan-Meier Survival Analysis
CESC	0.031	Kaplan-Meier Survival Analysis
LIHC	0.0066	Kaplan-Meier Survival Analysis
LUAD	0.0045	Kaplan-Meier Survival Analysis
UVM	0.00066	Kaplan-Meier Survival Analysis
OV	0.018	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000262814 (Gene tree)
Gene ID: 6182
Gene Symbol: MRPL12
Alias: MRPL7/L12|MRPL7|RPML12
Full Name: mitochondrial ribosomal protein L12
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 4,170 bases
Position: chr17:81,703,357-81,707,526
Accession: 10378
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000333837	Ribosomal_L12	PF00542.19	1.4e-17	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000333676	MRPL12-201	1028	-	ENSP00000333837	198 (aa)	-	P52815

Gene Model

Click here to download ENSG00000262814's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000262814	rs73354145	17	81706393	?	Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes	28736931	unit increase	0.018	GO_1903491\|EFO_0001360\|EFO_0007806\|GO_1901557
ENSG00000262814	rs73354145	17	81706393	?	LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes	28736931	unit increase	0.032	EFO_0007804\|GO_1903491\|EFO_0001360\|GO_1901557

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000262814's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000262814	MRPL12	94	66.492	ENSAPOG00000005018	mrpl12	93	68.023	Acanthochromis_polyacanthus
ENSG00000262814	MRPL12	97	60.309	ENSACIG00000006182	mrpl12	90	66.071	Amphilophus_citrinellus
ENSG00000262814	MRPL12	94	64.921	ENSAOCG00000003859	mrpl12	87	67.442	Amphiprion_ocellaris
ENSG00000262814	MRPL12	94	64.921	ENSAPEG00000005897	mrpl12	87	67.442	Amphiprion_percula
ENSG00000262814	MRPL12	97	61.538	ENSATEG00000023948	mrpl12	97	60.417	Anabas_testudineus
ENSG00000262814	MRPL12	86	68.824	ENSACAG00000010743	MRPL12	76	67.647	Anolis_carolinensis
ENSG00000262814	MRPL12	100	91.414	ENSANAG00000037237	-	100	90.404	Aotus_nancymaae
ENSG00000262814	MRPL12	100	87.940	ENSANAG00000020985	-	100	87.940	Aotus_nancymaae
ENSG00000262814	MRPL12	88	65.517	ENSACLG00000022963	mrpl12	87	66.279	Astatotilapia_calliptera
ENSG00000262814	MRPL12	86	67.647	ENSAMXG00000032543	mrpl12	87	67.647	Astyanax_mexicanus
ENSG00000262814	MRPL12	100	85.859	ENSBTAG00000000417	MRPL12	100	85.859	Bos_taurus
ENSG00000262814	MRPL12	73	43.448	WBGene00012361	mrpl-12	80	43.448	Caenorhabditis_elegans
ENSG00000262814	MRPL12	100	92.424	ENSCJAG00000001652	MRPL12	100	92.424	Callithrix_jacchus
ENSG00000262814	MRPL12	100	85.859	ENSCHIG00000027210	MRPL12	100	85.859	Capra_hircus
ENSG00000262814	MRPL12	100	87.374	ENSTSYG00000009746	MRPL12	100	87.374	Carlito_syrichta
ENSG00000262814	MRPL12	100	85.427	ENSCPOG00000035389	MRPL12	100	85.427	Cavia_porcellus
ENSG00000262814	MRPL12	100	92.929	ENSCCAG00000026887	MRPL12	100	92.929	Cebus_capucinus
ENSG00000262814	MRPL12	100	95.455	ENSCATG00000045041	MRPL12	100	95.455	Cercocebus_atys
ENSG00000262814	MRPL12	100	83.920	ENSCLAG00000012764	MRPL12	100	83.920	Chinchilla_lanigera
ENSG00000262814	MRPL12	100	96.465	ENSCSAG00000002234	MRPL12	100	96.465	Chlorocebus_sabaeus
ENSG00000262814	MRPL12	100	70.352	ENSCPBG00000011476	MRPL12	100	71.357	Chrysemys_picta_bellii
ENSG00000262814	MRPL12	88	41.489	ENSCING00000012945	-	94	44.751	Ciona_intestinalis
ENSG00000262814	MRPL12	100	97.475	ENSCANG00000029130	MRPL12	100	97.475	Colobus_angolensis_palliatus
ENSG00000262814	MRPL12	96	83.938	ENSCGRG00001005393	Mrpl12	100	84.314	Cricetulus_griseus_chok1gshd
ENSG00000262814	MRPL12	96	82.902	ENSCGRG00000015907	Mrpl12	100	82.353	Cricetulus_griseus_crigri
ENSG00000262814	MRPL12	94	63.542	ENSCSEG00000009238	mrpl12	86	67.251	Cynoglossus_semilaevis
ENSG00000262814	MRPL12	88	67.816	ENSCVAG00000008710	mrpl12	87	66.860	Cyprinodon_variegatus
ENSG00000262814	MRPL12	93	60.417	ENSDARG00000038768	mrpl12	88	61.047	Danio_rerio
ENSG00000262814	MRPL12	100	81.818	ENSDNOG00000042484	MRPL12	100	81.818	Dasypus_novemcinctus
ENSG00000262814	MRPL12	100	85.427	ENSDORG00000008074	Mrpl12	100	87.940	Dipodomys_ordii
ENSG00000262814	MRPL12	89	35.165	FBgn0011787	mRpL12	73	38.686	Drosophila_melanogaster
ENSG00000262814	MRPL12	100	84.925	ENSEASG00005005780	MRPL12	100	86.432	Equus_asinus_asinus
ENSG00000262814	MRPL12	100	84.925	ENSECAG00000009323	MRPL12	100	86.432	Equus_caballus
ENSG00000262814	MRPL12	100	80.303	ENSEEUG00000015613	MRPL12	100	80.303	Erinaceus_europaeus
ENSG00000262814	MRPL12	91	61.290	ENSELUG00000010073	mrpl12	88	63.953	Esox_lucius
ENSG00000262814	MRPL12	87	84.483	ENSFDAG00000014977	MRPL12	99	86.127	Fukomys_damarensis
ENSG00000262814	MRPL12	88	67.816	ENSFHEG00000014518	mrpl12	92	68.605	Fundulus_heteroclitus
ENSG00000262814	MRPL12	87	64.162	ENSGMOG00000008213	mrpl12	86	62.791	Gadus_morhua
ENSG00000262814	MRPL12	89	64.641	ENSGALG00000045753	MRPL12	83	69.620	Gallus_gallus
ENSG00000262814	MRPL12	94	63.874	ENSGAFG00000003529	mrpl12	80	67.442	Gambusia_affinis
ENSG00000262814	MRPL12	98	57.732	ENSGACG00000010541	mrpl12	97	57.732	Gasterosteus_aculeatus
ENSG00000262814	MRPL12	100	74.372	ENSGAGG00000013180	MRPL12	100	74.372	Gopherus_agassizii
ENSG00000262814	MRPL12	100	98.990	ENSGGOG00000009356	MRPL12	100	98.990	Gorilla_gorilla
ENSG00000262814	MRPL12	94	63.158	ENSHBUG00000004986	mrpl12	96	59.574	Haplochromis_burtoni
ENSG00000262814	MRPL12	100	83.920	ENSHGLG00000009470	MRPL12	99	84.925	Heterocephalus_glaber_female
ENSG00000262814	MRPL12	97	82.383	ENSHGLG00100005034	MRPL12	97	81.250	Heterocephalus_glaber_male
ENSG00000262814	MRPL12	92	64.324	ENSHCOG00000018775	mrpl12	88	65.698	Hippocampus_comes
ENSG00000262814	MRPL12	86	68.235	ENSIPUG00000007392	Mrpl12	87	68.235	Ictalurus_punctatus
ENSG00000262814	MRPL12	100	86.935	ENSSTOG00000031761	MRPL12	100	87.437	Ictidomys_tridecemlineatus
ENSG00000262814	MRPL12	100	85.075	ENSJJAG00000018729	Mrpl12	100	84.080	Jaculus_jaculus
ENSG00000262814	MRPL12	95	62.371	ENSKMAG00000012978	mrpl12	87	63.953	Kryptolebias_marmoratus
ENSG00000262814	MRPL12	94	63.874	ENSLBEG00000024610	mrpl12	87	64.000	Labrus_bergylta
ENSG00000262814	MRPL12	100	85.427	ENSLAFG00000004594	MRPL12	100	86.500	Loxodonta_africana
ENSG00000262814	MRPL12	100	95.960	ENSMFAG00000042253	MRPL12	100	95.960	Macaca_fascicularis
ENSG00000262814	MRPL12	100	95.960	ENSMNEG00000016503	MRPL12	100	95.960	Macaca_nemestrina
ENSG00000262814	MRPL12	100	94.949	ENSMLEG00000041715	MRPL12	100	94.949	Mandrillus_leucophaeus
ENSG00000262814	MRPL12	86	67.251	ENSMAMG00000020677	mrpl12	87	66.279	Mastacembelus_armatus
ENSG00000262814	MRPL12	88	65.517	ENSMZEG00005021473	mrpl12	87	66.279	Maylandia_zebra
ENSG00000262814	MRPL12	88	65.517	ENSMZEG00005011802	mrpl12	87	66.279	Maylandia_zebra
ENSG00000262814	MRPL12	100	85.354	ENSMAUG00000002006	Mrpl12	100	83.333	Mesocricetus_auratus
ENSG00000262814	MRPL12	100	87.374	ENSMICG00000047418	MRPL12	100	89.394	Microcebus_murinus
ENSG00000262814	MRPL12	100	84.080	ENSMOCG00000019919	Mrpl12	100	85.572	Microtus_ochrogaster
ENSG00000262814	MRPL12	95	62.434	ENSMMOG00000011266	mrpl12	86	65.294	Mola_mola
ENSG00000262814	MRPL12	100	76.768	ENSMODG00000002902	MRPL12	100	77.778	Monodelphis_domestica
ENSG00000262814	MRPL12	94	63.874	ENSMALG00000001391	mrpl12	87	64.535	Monopterus_albus
ENSG00000262814	MRPL12	100	84.577	MGP_CAROLIEiJ_G0017522	Mrpl12	100	84.080	Mus_caroli
ENSG00000262814	MRPL12	100	84.080	ENSMUSG00000039640	Mrpl12	100	83.582	Mus_musculus
ENSG00000262814	MRPL12	100	84.577	MGP_PahariEiJ_G0018648	Mrpl12	100	84.080	Mus_pahari
ENSG00000262814	MRPL12	100	84.080	MGP_SPRETEiJ_G0018366	Mrpl12	100	83.582	Mus_spretus
ENSG00000262814	MRPL12	100	82.759	ENSNGAG00000010189	Mrpl12	100	83.744	Nannospalax_galili
ENSG00000262814	MRPL12	94	62.827	ENSNBRG00000020817	mrpl12	88	66.279	Neolamprologus_brichardi
ENSG00000262814	MRPL12	100	98.485	ENSNLEG00000035133	MRPL12	100	98.485	Nomascus_leucogenys
ENSG00000262814	MRPL12	85	69.412	ENSMEUG00000010783	-	100	70.000	Notamacropus_eugenii
ENSG00000262814	MRPL12	100	82.915	ENSODEG00000008765	MRPL12	100	81.407	Octodon_degus
ENSG00000262814	MRPL12	67	33.333	ENSOANG00000021537	-	100	31.690	Ornithorhynchus_anatinus
ENSG00000262814	MRPL12	94	66.321	ENSORLG00000007092	mrpl12	86	68.023	Oryzias_latipes
ENSG00000262814	MRPL12	94	66.321	ENSORLG00020001351	mrpl12	86	68.023	Oryzias_latipes_hni
ENSG00000262814	MRPL12	94	66.839	ENSORLG00015012065	mrpl12	86	68.605	Oryzias_latipes_hsok
ENSG00000262814	MRPL12	93	67.196	ENSOMEG00000006871	mrpl12	86	68.605	Oryzias_melastigma
ENSG00000262814	MRPL12	100	85.075	ENSOGAG00000005297	MRPL12	100	84.577	Otolemur_garnettii
ENSG00000262814	MRPL12	98	85.128	ENSOARG00000018221	MRPL12	87	85.128	Ovis_aries
ENSG00000262814	MRPL12	100	99.495	ENSPPAG00000042009	MRPL12	100	99.495	Pan_paniscus
ENSG00000262814	MRPL12	100	86.364	ENSPPRG00000002570	MRPL12	100	86.364	Panthera_pardus
ENSG00000262814	MRPL12	92	84.153	ENSPTIG00000019530	MRPL12	87	88.372	Panthera_tigris_altaica
ENSG00000262814	MRPL12	100	99.495	ENSPTRG00000043438	MRPL12	100	99.495	Pan_troglodytes
ENSG00000262814	MRPL12	100	95.960	ENSPANG00000019331	MRPL12	100	95.960	Papio_anubis
ENSG00000262814	MRPL12	92	63.298	ENSPKIG00000012772	mrpl12	86	63.690	Paramormyrops_kingsleyae
ENSG00000262814	MRPL12	85	68.966	ENSPSIG00000018211	MRPL12	87	68.966	Pelodiscus_sinensis
ENSG00000262814	MRPL12	95	65.957	ENSPMGG00000008509	mrpl12	87	67.442	Periophthalmus_magnuspinnatus
ENSG00000262814	MRPL12	100	86.000	ENSPEMG00000005848	Mrpl12	100	84.000	Peromyscus_maniculatus_bairdii
ENSG00000262814	MRPL12	89	57.778	ENSPMAG00000001357	mrpl12	77	60.366	Petromyzon_marinus
ENSG00000262814	MRPL12	100	78.000	ENSPCIG00000029585	MRPL12	100	78.000	Phascolarctos_cinereus
ENSG00000262814	MRPL12	94	65.969	ENSPFOG00000024338	mrpl12	81	69.186	Poecilia_formosa
ENSG00000262814	MRPL12	94	65.969	ENSPLAG00000002664	mrpl12	87	69.186	Poecilia_latipinna
ENSG00000262814	MRPL12	93	67.027	ENSPMEG00000021484	mrpl12	92	65.789	Poecilia_mexicana
ENSG00000262814	MRPL12	88	66.092	ENSPREG00000004225	mrpl12	92	66.279	Poecilia_reticulata
ENSG00000262814	MRPL12	100	97.475	ENSPPYG00000008744	MRPL12	100	97.475	Pongo_abelii
ENSG00000262814	MRPL12	100	71.357	ENSPCAG00000015148	MRPL12	100	71.357	Procavia_capensis
ENSG00000262814	MRPL12	100	91.919	ENSPCOG00000016998	MRPL12	100	91.919	Propithecus_coquereli
ENSG00000262814	MRPL12	100	85.354	ENSPVAG00000011002	MRPL12	100	85.354	Pteropus_vampyrus
ENSG00000262814	MRPL12	92	64.674	ENSPNYG00000008879	mrpl12	87	65.680	Pundamilia_nyererei
ENSG00000262814	MRPL12	86	65.882	ENSPNAG00000003320	mrpl12	87	69.412	Pygocentrus_nattereri
ENSG00000262814	MRPL12	96	81.250	ENSRNOG00000036695	Mrpl12	74	80.788	Rattus_norvegicus
ENSG00000262814	MRPL12	100	95.960	ENSRBIG00000029573	MRPL12	100	95.960	Rhinopithecus_bieti
ENSG00000262814	MRPL12	100	95.960	ENSRROG00000010180	MRPL12	100	95.960	Rhinopithecus_roxellana
ENSG00000262814	MRPL12	69	44.521	YGL068W	-	74	42.384	Saccharomyces_cerevisiae
ENSG00000262814	MRPL12	88	92.000	ENSSBOG00000033734	MRPL12	90	92.442	Saimiri_boliviensis_boliviensis
ENSG00000262814	MRPL12	86	63.743	ENSSFOG00015023051	mrpl12	85	61.538	Scleropages_formosus
ENSG00000262814	MRPL12	96	60.714	ENSSFOG00015023998	mrpl12	86	65.476	Scleropages_formosus
ENSG00000262814	MRPL12	94	66.492	ENSSMAG00000001700	mrpl12	87	66.860	Scophthalmus_maximus
ENSG00000262814	MRPL12	95	67.021	ENSSDUG00000014547	mrpl12	90	68.605	Seriola_dumerili
ENSG00000262814	MRPL12	94	67.539	ENSSLDG00000003829	mrpl12	87	66.860	Seriola_lalandi_dorsalis
ENSG00000262814	MRPL12	92	68.852	ENSSPUG00000011062	MRPL12	91	67.442	Sphenodon_punctatus
ENSG00000262814	MRPL12	94	66.492	ENSSPAG00000010692	mrpl12	87	68.023	Stegastes_partitus
ENSG00000262814	MRPL12	100	84.343	ENSSSCG00000033148	MRPL12	100	84.343	Sus_scrofa
ENSG00000262814	MRPL12	79	58.025	ENSTGUG00000003446	MRPL12	100	56.962	Taeniopygia_guttata
ENSG00000262814	MRPL12	88	64.943	ENSTRUG00000021764	mrpl12	68	67.442	Takifugu_rubripes
ENSG00000262814	MRPL12	94	63.351	ENSTNIG00000010438	mrpl12	82	66.860	Tetraodon_nigroviridis
ENSG00000262814	MRPL12	100	81.313	ENSTBEG00000010871	MRPL12	100	81.313	Tupaia_belangeri
ENSG00000262814	MRPL12	100	85.354	ENSTTRG00000007611	MRPL12	100	85.354	Tursiops_truncatus
ENSG00000262814	MRPL12	100	69.421	ENSUAMG00000016771	MRPL12	100	69.421	Ursus_americanus
ENSG00000262814	MRPL12	88	84.659	ENSUMAG00000016332	MRPL12	72	86.127	Ursus_maritimus
ENSG00000262814	MRPL12	100	86.869	ENSVVUG00000020000	MRPL12	100	86.869	Vulpes_vulpes
ENSG00000262814	MRPL12	94	65.969	ENSXMAG00000028444	mrpl12	87	69.767	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	8626705.	TAS	Function
GO:0003735	structural constituent of ribosome	-	IEA	Function
GO:0005515	protein binding	17337445.19103604.22003127.	IPI	Function
GO:0005739	mitochondrion	17337445.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	20186120.	IDA	Component
GO:0006390	mitochondrial transcription	21873635.	IBA	Process
GO:0006390	mitochondrial transcription	17337445.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	17337445.	IDA	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.