EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26500060	A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization.	Oncogene	2016 Jun 16	Nowicka AM	doi: 10.1038/onc.2015.400
17977820	Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity.	J Biol Chem	2008 Jan 4	Palkowitsch L	-
14764716	The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop.	J Immunol	2004 Feb 15	Yang F	-
21383699	Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-??B: implication in breast cancer metastasis.	Oncogene	2011 Jul 14	Bist P	doi: 10.1038/onc.2011.28
28515148	NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer.	Cancer Res	2017 Jul 15	Elsarraj HS	doi: 10.1158/0008-5472.CAN-16-2794
27367027	Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis.	Oncotarget	2016 Aug 2	An J	doi: 10.18632/oncotarget.10321.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chrX	154552130	Missense_Mutation	novel	S43L	0.53
BLCA	chrX	154552144	Missense_Mutation	novel	P48A	0.43
COAD	chrX	154558599	Missense_Mutation	novel	S156I	0.25
GBM	chrX	154542374	5'Flank	novel		0.3
GBM	chrX	154552043	Missense_Mutation	novel	V14G	0.1
KIRP	chrX	154562827	Silent	novel	D262D	0.17
KIRP	chrX	154542443	5'Flank	novel		0.48
LGG	chrX	154552011	Silent	novel	R3R	0.06
LUAD	chrX	154552140	Silent	novel	G46G	0.37
LUAD	chrX	154542390	5'Flank	novel		0.33
LUAD	chrX	154552052	Missense_Mutation	novel	S17T	0.07
LUSC	chrX	154558573	Silent	novel	T147T	0.41
OV	chrX	154542377	5'Flank	NA		0.14
OV	chrX	154552080	Silent	novel	V26V	0.1
READ	chrX	154562879	Missense_Mutation	novel	V280M	0.19
READ	chrX	154558638	Missense_Mutation	novel	A169D	0.24
SKCM	chrX	154562951	Nonsense_Mutation	novel	Q304*	0.67
UCEC	chrX	154542412	5'Flank	rs782201526		0.33
UCEC	chrX	154552180	Nonsense_Mutation	novel	E60*	0.56
UCEC	chrX	154558607	Missense_Mutation	novel	R159S	0.19
UCEC	chrX	154542283	Missense_Mutation	novel	V7A	0.24
UCEC	chrX	154562934	Missense_Mutation	novel	V298A	0.27
UCEC	chrX	154552177	Nonsense_Mutation	novel	Q59*	0.38
UCEC	chrX	154556286	Silent	novel	L103L	0.35
UCEC	chrX	154556264	Missense_Mutation	novel	K96T	0.4
UCEC	chrX	154562885	Missense_Mutation	novel	D282N	0.35
UCEC	chrX	154562926	Missense_Mutation	novel	M295I	0.24
UCEC	chrX	154552093	Missense_Mutation	novel	S31T	0.4
UCEC	chrX	154542435	5'Flank	novel		0.31
UCEC	chrX	154558567	Missense_Mutation	novel	Q145H	0.09
UCEC	chrX	154552086	Silent	rs782455868	G28G	0.36
UCEC	chrX	154542435	5'Flank	novel		0.3
UCEC	chrX	154562885	Missense_Mutation	novel	D282N	0.2
UCEC	chrX	154542333	5'Flank	novel		0.29
UCEC	chrX	154552070	Missense_Mutation	novel	D23A	0.15
UCEC	chrX	154558586	Missense_Mutation	novel	E152K	0.06
UCEC	chrX	154552084	Missense_Mutation	novel	G28C	0.35
UCEC	chrX	154552088	Missense_Mutation	novel	E29A	0.38
UCEC	chrX	154542251	5'UTR	rs782316100		0.2

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1932	3.2002e-05
DLBC	AMP	0.1458	0.24013
HNSC	AMP	0.2088	0.0095371
KIRC	AMP	0.0436	0.12739
LIHC	AMP	0.1514	0.011319
LUAD	AMP	0.2151	1.4252e-08
LUSC	AMP	0.1796	0.08275
OV	AMP	0.3143	2.176e-06
PAAD	AMP	0.0761	0.041079
READ	AMP	0.1576	0.14805
STAD	AMP	0.1134	0.0021069
TGCT	DEL	0.0733	0.08422
THCA	DEL	0.006	0.21991
UCS	DEL	0.3036	0.063955

Survival Analysis

Cancer	P-value	Q-value
STAD	0.022	Kaplan-Meier Survival Analysis
SARC	0.01	Kaplan-Meier Survival Analysis
ACC	0.022	Kaplan-Meier Survival Analysis
UCS	0.041	Kaplan-Meier Survival Analysis
SKCM	0.05	Kaplan-Meier Survival Analysis
LUSC	0.047	Kaplan-Meier Survival Analysis
PAAD	0.027	Kaplan-Meier Survival Analysis
CESC	0.011	Kaplan-Meier Survival Analysis
LAML	0.005	Kaplan-Meier Survival Analysis
UCEC	0.0048	Kaplan-Meier Survival Analysis
LGG	0.0044	Kaplan-Meier Survival Analysis
UVM	0.0023	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000269335 (Gene tree)
Gene ID: 8517
Gene Symbol: IKBKG
Alias: IKK-gamma|NEMO|Fip3p|FIP-3|FIP3|ZC2HC9|IP2|IP1
Full Name: inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 27,375 bases
Position: chrX:154,541,199-154,568,573
Accession: 5961
RBP type: non-canonical RBP
Summary: This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25586786	Differentiation of primordial germ cells from induced pluripotent stem cells of primary ovarian insufficiency.	Hum Reprod	2015 Mar	Leng L	doi: 10.1093/humrep/deu358
11160844	The NF-kappaB pathway in human endometrium and first trimester decidua.	Mol Hum Reprod	2001 Feb	King AE	-
23028469	NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses.	PLoS One	2012	Wang L	doi: 10.1371/journal.pone.0043756
18481966	Mechanisms regulating targeting of recycling endosomes to the cleavage furrow during cytokinesis.	Biochem Soc Trans	2008 Jun	Simon GC	doi: 10.1042/BST0360391.

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000612051	IKBKG-209	1972	-	ENSP00000480431	48 (aa)	-	A0A087WWQ9
ENST00000445622	IKBKG-204	693	-	ENSP00000395205	138 (aa)	-	C9JCG6
ENST00000618670	IKBKG-214	2069	-	ENSP00000483825	487 (aa)	-	Q9Y6K9
ENST00000619941	IKBKG-215	1463	-	ENSP00000478979	412 (aa)	-	A0A087WUW6
ENST00000615186	IKBKG-210	488	-	ENSP00000479144	115 (aa)	-	A0A087WV30
ENST00000611176	IKBKG-208	1654	-	ENSP00000478616	320 (aa)	-	Q9Y6K9
ENST00000611071	IKBKG-207	2103	-	ENSP00000479662	419 (aa)	-	Q9Y6K9
ENST00000617207	IKBKG-212	1949	-	ENSP00000484023	418 (aa)	-	A0A087X1B1
ENST00000413620	IKBKG-201	892	-	ENSP00000398579	195 (aa)	-	C9J2V2
ENST00000594239	IKBKG-206	2299	-	ENSP00000471166	419 (aa)	-	Q9Y6K9
ENST00000615874	IKBKG-211	1460	-	ENSP00000483381	411 (aa)	-	A0A087X0G7
ENST00000440286	IKBKG-203	960	-	ENSP00000394934	250 (aa)	-	C9JN51
ENST00000617838	IKBKG-213	285	-	-	- (aa)	-	-
ENST00000422680	IKBKG-202	841	-	ENSP00000390368	172 (aa)	-	C9JH59
ENST00000492469	IKBKG-205	552	-	ENSP00000484275	181 (aa)	-	A0A087X1K7

Gene Model

Click here to download ENSG00000269335's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa01523	Antifolate resistance	KEGG
hsa04010	MAPK signaling pathway	KEGG
hsa04014	Ras signaling pathway	KEGG
hsa04062	Chemokine signaling pathway	KEGG
hsa04064	NF-kappa B signaling pathway	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04210	Apoptosis	KEGG
hsa04380	Osteoclast differentiation	KEGG
hsa04620	Toll-like receptor signaling pathway	KEGG
hsa04621	NOD-like receptor signaling pathway	KEGG
hsa04622	RIG-I-like receptor signaling pathway	KEGG
hsa04623	Cytosolic DNA-sensing pathway	KEGG
hsa04625	C-type lectin receptor signaling pathway	KEGG
hsa04657	IL-17 signaling pathway	KEGG
hsa04658	Th1 and Th2 cell differentiation	KEGG
hsa04659	Th17 cell differentiation	KEGG
hsa04660	T cell receptor signaling pathway	KEGG
hsa04662	B cell receptor signaling pathway	KEGG
hsa04668	TNF signaling pathway	KEGG
hsa04920	Adipocytokine signaling pathway	KEGG
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	KEGG
hsa05131	Shigellosis	KEGG
hsa05142	Chagas disease (American trypanosomiasis)	KEGG
hsa05145	Toxoplasmosis	KEGG
hsa05160	Hepatitis C	KEGG
hsa05161	Hepatitis B	KEGG
hsa05162	Measles	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05164	Influenza A	KEGG
hsa05165	Human papillomavirus infection	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG
hsa05167	Kaposi sarcoma-associated herpesvirus infection	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG
hsa05169	Epstein-Barr virus infection	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05203	Viral carcinogenesis	KEGG
hsa05212	Pancreatic cancer	KEGG
hsa05215	Prostate cancer	KEGG
hsa05220	Chronic myeloid leukemia	KEGG
hsa05221	Acute myeloid leukemia	KEGG
hsa05222	Small cell lung cancer	KEGG
hsa05340	Primary immunodeficiency	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000269335	Hemoglobin A, Glycosylated	3E-11	26366553
ENSG00000269335	Hemoglobins	3E-11	26366553

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000269335's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000151	ubiquitin ligase complex	17314283.	IPI	Component
GO:0000187	activation of MAPK activity	-	TAS	Process
GO:0000922	spindle pole	24561039.	IDA	Component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0002756	MyD88-independent toll-like receptor signaling pathway	-	TAS	Process
GO:0005515	protein binding	9751060.11113112.11418127.11551959.12486103.14653779.14743216.15474016.15601829.15749833.16126728.16129692.16319058.16874300.16938294.17363905.17363973.17568778.17948050.18266467.18287044.18462684.18583959.19365808.19373254.19666608.19706536.19875381.20010814.20098747.20368414.20434986.20970423.21212807.21217772.21383699.21423167.21455180.21458669.21474709.21709223.21811235.21903422.21988832.23032186.23104095.24189400.24270572.24618592.25036637.25852190.25861989.26334375.26496610.27070702.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	14651848.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	11113112.14651848.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006915	apoptotic process	9927690.	TAS	Process
GO:0006954	inflammatory response	18626576.	TAS	Process
GO:0006955	immune response	9751060.	TAS	Process
GO:0006974	cellular response to DNA damage stimulus	14651848.	IDA	Process
GO:0006974	cellular response to DNA damage stimulus	25861989.	IMP	Process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	18626576.	TAS	Process
GO:0007254	JNK cascade	-	TAS	Process
GO:0008385	IkappaB kinase complex	21873635.	IBA	Component
GO:0008385	IkappaB kinase complex	23776175.	IDA	Component
GO:0008385	IkappaB kinase complex	18626576.	TAS	Component
GO:0009615	response to virus	18626576.	TAS	Process
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0016239	positive regulation of macroautophagy	-	ISS	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0019904	protein domain specific binding	15341735.	IPI	Function
GO:0031625	ubiquitin protein ligase binding	23453807.	IPI	Function
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0042802	identical protein binding	18462684.21988832.	IPI	Function
GO:0042803	protein homodimerization activity	23091055.	IDA	Function
GO:0042975	peroxisome proliferator activated receptor binding	-	IEA	Function
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	21873635.	IBA	Process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	17702576.	IDA	Process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	TAS	Process
GO:0043276	anoikis	-	ISS	Process
GO:0045087	innate immune response	18626576.	TAS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	23091055.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0046982	protein heterodimerization activity	23091055.	IDA	Function
GO:0050852	T cell receptor signaling pathway	15125833.	NAS	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	15620648.	IDA	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	18626576.	TAS	Process
GO:0051403	stress-activated MAPK cascade	-	TAS	Process
GO:0051650	establishment of vesicle localization	24561039.	IMP	Process
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	-	TAS	Process
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	21873635.	IBA	Function
GO:0072686	mitotic spindle	24561039.	IDA	Component
GO:1901215	negative regulation of neuron death	18221368.	TAS	Process
GO:1990450	linear polyubiquitin binding	23453807.	IDA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.