Cancer | Chr | Position | Mutation Type | dbSNP | Protein-change | Allele Freq | RBD |
---|---|---|---|---|---|---|---|
ACC | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
ESCA | |||||||
ESCA | |||||||
GBM | |||||||
GBM | |||||||
HNSC | |||||||
HNSC | |||||||
HNSC | |||||||
KIRC | |||||||
KIRC | |||||||
KIRC | |||||||
KIRP | |||||||
KIRP | |||||||
LAML | |||||||
LGG | |||||||
LGG | |||||||
LIHC | |||||||
LIHC | |||||||
LIHC | |||||||
LIHC | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUSC | |||||||
OV | |||||||
OV | |||||||
OV | |||||||
OV | |||||||
PAAD | |||||||
PAAD | |||||||
PRAD | |||||||
SARC | |||||||
SARC | |||||||
SKCM | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC |
Cancer | Type | Freq | Q-value |
---|---|---|---|
KIRP | |||
READ | |||
UCS |
Cancer | P-value | Q-value |
---|---|---|
KIRC | ||
ACC | ||
UCS | ||
HNSC | ||
SKCM | ||
BRCA | ||
PAAD | ||
PCPG | ||
CESC | ||
LIHC | ||
LGG | ||
UVM |
Protein ID | Domain | Pfam ID | E-value | Domain number | Total number |
---|---|---|---|---|---|
ENSP00000472414 | 2OG-FeII_Oxy | PF03171.20 | 0.00018 | 1 | 1 |
PID | Title | Article | Time | Author | Doi |
---|---|---|---|---|---|
23026137 |
Transcript ID | Name | Length | RefSeq ID | Protein ID | Length | RefSeq ID | UniportKB ID |
---|---|---|---|---|---|---|---|
ENST00000598654 | EGLN2-215 | 590 | - | ENSP00000471568 | 101 (aa) | - | M0R110 |
ENST00000593477 | EGLN2-205 | 1391 | - | - | - (aa) | - | - |
ENST00000599579 | EGLN2-216 | 3894 | - | - | - (aa) | - | - |
ENST00000594140 | EGLN2-209 | 991 | - | ENSP00000472414 | 125 (aa) | - | A0A0C4DGR4 |
ENST00000602166 | EGLN2-218 | 684 | - | - | - (aa) | - | - |
ENST00000593525 | EGLN2-206 | 709 | - | ENSP00000469272 | 77 (aa) | - | M0QXM8 |
ENST00000593397 | EGLN2-203 | 572 | - | ENSP00000472146 | 72 (aa) | - | M0R1W4 |
ENST00000593972 | EGLN2-208 | 935 | - | ENSP00000471546 | 139 (aa) | - | M0R0Z6 |
ENST00000595621 | EGLN2-212 | 758 | - | ENSP00000471944 | 96 (aa) | - | M0R1L0 |
ENST00000303961 | EGLN2-201 | 2102 | - | ENSP00000307080 | 407 (aa) | - | Q96KS0 |
ENST00000406058 | EGLN2-202 | 2150 | - | ENSP00000385253 | 407 (aa) | - | Q96KS0 |
ENST00000593726 | EGLN2-207 | 2821 | - | ENSP00000469686 | 407 (aa) | - | Q96KS0 |
ENST00000594380 | EGLN2-210 | 597 | - | ENSP00000470968 | 87 (aa) | - | M0R035 |
ENST00000601733 | EGLN2-217 | 584 | - | ENSP00000469323 | 94 (aa) | - | M0QXR0 |
ENST00000593445 | EGLN2-204 | 3034 | - | - | - (aa) | - | - |
ENST00000597746 | EGLN2-214 | 459 | - | ENSP00000472991 | 128 (aa) | - | M0R350 |
ENST00000595051 | EGLN2-211 | 477 | - | ENSP00000471740 | 51 (aa) | - | M0R1A3 |
ENST00000596517 | EGLN2-213 | 574 | - | ENSP00000472870 | 67 (aa) | - | M0R2X9 |
ensgID | Trait | pValue | Pubmed ID |
---|---|---|---|
ENSG00000269858 | Bronchodilator Agents | 3E-6 | 26634245 |
ENSG00000269858 | Forced Expiratory Volume | 3E-6 | 26634245 |
ENSG00000269858 | Bronchodilator Agents | 4E-6 | 26634245 |
ENSG00000269858 | Forced Expiratory Volume | 4E-6 | 26634245 |
ENSG00000269858 | Bronchodilator Agents | 4E-6 | 26634245 |
ENSG00000269858 | Forced Expiratory Volume | 4E-6 | 26634245 |
ENSG00000269858 | Bronchodilator Agents | 4E-6 | 26634245 |
ENSG00000269858 | Forced Expiratory Volume | 4E-6 | 26634245 |
ENSG00000269858 | Bronchodilator Agents | 5E-6 | 26634245 |
ENSG00000269858 | Forced Expiratory Volume | 5E-6 | 26634245 |
ENSG00000269858 | Smoking | 1E-8 | 20418890 |
ensgID | SNP | Chromosome | Position | SNP-risk | Trait | PubmedID | 95% CI | Or or BEAT | EFO ID |
---|---|---|---|---|---|---|---|---|---|
ENSG00000269858 | rs117139969 | 19 | 40806017 | T | Post bronchodilator FEV1 | 26634245 | NR unit decrease | 0.159 | EFO_0004314|GO_0097366 |
ENSG00000269858 | rs3733829 | 19 | 40804666 | G | Smoking behavior | 20418890 | [0.22-0.44] CPD increase | 0.33 | EFO_0004318 |
ENSG00000269858 | rs61750953 | 19 | 40800745 | T | Hematocrit | 27863252 | [0.066-0.122] unit decrease | 0.09388035 | EFO_0004348 |
ENSG00000269858 | rs184088518 | 19 | 40799233 | T | Hemoglobin concentration | 27863252 | [0.076-0.125] unit decrease | 0.1005758 | EFO_0004509 |
ENSG00000269858 | rs61750953 | 19 | 40800745 | T | Hemoglobin concentration | 27863252 | [0.06-0.117] unit decrease | 0.08824054 | EFO_0004509 |
ENSG00000269858 | rs117821847 | 19 | 40804983 | T | Post bronchodilator FEV1 | 26634245 | NR unit increase | 0.159 | EFO_0004314|GO_0097366 |
ENSG00000269858 | rs117391664 | 19 | 40803245 | A | Post bronchodilator FEV1 | 26634245 | NR unit increase | 0.159 | EFO_0004314|GO_0097366 |
ENSG00000269858 | rs144553930 | 19 | 40807356 | T | Post bronchodilator FEV1 | 26634245 | NR unit increase | 0.16 | EFO_0004314|GO_0097366 |
ENSG00000269858 | rs117851058 | 19 | 40803685 | A | Post bronchodilator FEV1 | 26634245 | NR unit increase | 0.161 | EFO_0004314|GO_0097366 |
ENSG00000269858 | rs184088518 | 19 | 40799233 | ? | Red blood cell count | 30595370 | EFO_0004305 | ||
ENSG00000269858 | rs3733829 | 19 | 40804666 | G | Smoking behaviour (cigarettes smoked per day) | 30617275 | [0.015-0.035] unit increase (replication) | 0.025 | EFO_0006525 |
Ensembl ID | Gene Symbol | Coverage | Identiy | Ortholog | Gene Symbol | Coverage | Identiy | Species |
---|---|---|---|---|---|---|---|---|
ENSG00000269858 | EGLN2 | 86 | 87.850 | ENSAPOG00000011715 | - | 88 | 87.850 | Acanthochromis_polyacanthus |
ENSG00000269858 | EGLN2 | 100 | 99.200 | ENSCAPG00000013614 | - | 100 | 99.200 | Cavia_aperea |
ENSG00000269858 | EGLN2 | 100 | 98.400 | ENSDORG00000025780 | - | 100 | 98.400 | Dipodomys_ordii |
ENSG00000269858 | EGLN2 | 86 | 88.785 | ENSGACG00000009469 | egln2 | 94 | 76.786 | Gasterosteus_aculeatus |
ENSG00000269858 | EGLN2 | 87 | 87.156 | ENSHCOG00000006766 | - | 94 | 87.156 | Hippocampus_comes |
ENSG00000269858 | EGLN2 | 99 | 96.774 | ENSJJAG00000014701 | - | 99 | 96.774 | Jaculus_jaculus |
ENSG00000269858 | EGLN2 | 100 | 98.400 | ENSMAUG00000014877 | - | 100 | 98.400 | Mesocricetus_auratus |
ENSG00000269858 | EGLN2 | 100 | 98.400 | ENSODEG00000001673 | - | 100 | 98.400 | Octodon_degus |
ENSG00000269858 | EGLN2 | 96 | 85.833 | ENSPKIG00000009905 | - | 97 | 85.833 | Paramormyrops_kingsleyae |
ENSG00000269858 | EGLN2 | 96 | 85.000 | ENSSFOG00015005231 | - | 97 | 85.000 | Scleropages_formosus |
ENSG00000269858 | EGLN2 | 86 | 89.720 | ENSSPUG00000018287 | - | 100 | 89.720 | Sphenodon_punctatus |
ENSG00000269858 | EGLN2 | 93 | 79.310 | ENSTNIG00000005924 | - | 96 | 79.310 | Tetraodon_nigroviridis |
ENSG00000269858 | EGLN2 | 100 | 99.200 | ENSUAMG00000013811 | - | 100 | 99.200 | Ursus_americanus |
Go ID | Go_term | PubmedID | Evidence | Category |
---|---|---|---|---|
GO:0001558 | regulation of cell growth | 11850811. | NAS | Process |
GO:0001666 | response to hypoxia | 11595184. | IDA | Process |
GO:0005515 | protein binding | 16511565.17353276.22286099. | IPI | Function |
GO:0005634 | nucleus | 11850811.12615973. | IDA | Component |
GO:0005654 | nucleoplasm | - | IDA | Component |
GO:0005654 | nucleoplasm | - | TAS | Component |
GO:0008198 | ferrous iron binding | 28594552. | IDA | Function |
GO:0008198 | ferrous iron binding | 12039559. | NAS | Function |
GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | 11595184.22955912. | IDA | Function |
GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 11598268.12039559. | IDA | Process |
GO:0019826 | oxygen sensor activity | 11595184. | IDA | Function |
GO:0030520 | intracellular estrogen receptor signaling pathway | 11850811. | NAS | Process |
GO:0031418 | L-ascorbic acid binding | - | IEA | Function |
GO:0031545 | peptidyl-proline 4-dioxygenase activity | 11598268.12039559. | IDA | Function |
GO:0043523 | regulation of neuron apoptotic process | 19587290. | IMP | Process |
GO:0045454 | cell redox homeostasis | 11595184. | IDA | Process |
GO:0045732 | positive regulation of protein catabolic process | 11595184. | IDA | Process |
GO:0055114 | oxidation-reduction process | - | IEA | Process |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | - | TAS | Process |