EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27527252	Tuning Specific Translation in Cancer Metastasis and Synaptic Memory: Control at the MNK-eIF4E Axis.	Trends Biochem Sci	2016 Oct	Bramham CR	doi: 10.1016/j.tibs.2016.07.008
27432794	The WASF3-NCKAP1-CYFIP1 Complex Is Essential for Breast Cancer Metastasis.	Cancer Res	2016 Sep 1	Teng Y	doi: 10.1158/0008-5472.CAN-16-0562
29706651	Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway.	Oncogene	2018 Jul	Chang JW	doi: 10.1038/s41388-018-0253-9

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr15	22917016	Intron	rs184171331		0.43
ACC	chr15	22932242	Missense_Mutation	rs569768747	A364V	0.88
BLCA	chr15	22879943	Silent	rs760077367	I1004I	0.66
BLCA	chr15	22892940	Missense_Mutation	novel	Q876E	0.08
BLCA	chr15	22943220	Silent	rs767926977	L174L	0.16
BLCA	chr15	22943176	Missense_Mutation	novel	K189R	0.42
BLCA	chr15	22870052	Missense_Mutation	novel	I1246M	0.1
BLCA	chr15	22939292	Missense_Mutation	novel	S232C	0.24
BLCA	chr15	22917878	Missense_Mutation	novel	F528L	0.41
BLCA	chr15	22947256	Silent	rs34148834	A10A	0.22
BLCA	chr15	22943220	Silent	rs767926977	L174L	0.12
BLCA	chr15	22882886	Silent	novel	L934L	0.18
BLCA	chr15	22937143	Silent	novel	K287K	0.22
BLCA	chr15	22882910	Silent	novel	I926I	0.8
BLCA	chr15	22910618	Missense_Mutation	novel	D724H	0.27
BLCA	chr15	22869964	3'UTR	novel		0.2
BLCA	chr15	22939257	Silent	novel	L244L	0.19
BLCA	chr15	22947280	Silent	rs748234246	A2A	0.54
BLCA	chr15	22939228	Missense_Mutation	novel	M253I	0.07
BRCA	chr15	22872929	Missense_Mutation	novel	I1165L	0.1
BRCA	chr15	22947257	Missense_Mutation	rs761297983	A10V	0.28
BRCA	chr15	22912275	Missense_Mutation	novel	E662D	0.14
BRCA	chr15	22875259	Missense_Mutation	novel	V1019M	0.06
BRCA	chr15	22947042	Silent	rs745649616	I56I	0.5
BRCA	chr15	22917262	Intron	novel		0.4
BRCA	chr15	22917016	Intron	rs184171331		0.18
BRCA	chr15	22926002	Missense_Mutation	novel	E447K	0.29
BRCA	chr15	22932267	Missense_Mutation	novel	H356N	0.1
BRCA	chr15	22873573	Missense_Mutation	rs748203521	E1123K	0.19
BRCA	chr15	22944594	Silent	novel	P117P	0.19
BRCA	chr15	22916598	Silent	novel	L569L	0.21
BRCA	chr15	22933806	Frame_Shift_Del	novel	*S330Lfs20**	0.17
BRCA	chr15	22939420	Silent	novel	K219K	0.15
BRCA	chr15	22882971	Missense_Mutation	novel	R906L	0.08
BRCA	chr15	22909225	Missense_Mutation	novel	R786Q	0.11
BRCA	chr15	22914832	Missense_Mutation	novel	F627L	0.09
CESC	chr15	22917862	Missense_Mutation	rs747329807	R534W	0.4
CESC	chr15	22927958	Missense_Mutation	rs374831208	A394V	0.31
CESC	chr15	22882964	Silent	rs145238748	F908F	0.28
CESC	chr15	22870103	Silent	rs369837466	G1229G	0.34
CESC	chr15	22879968	Missense_Mutation	novel	N996I	0.13
CESC	chr15	22916938	Intron	novel		0.1
CESC	chr15	22944634	Missense_Mutation	novel	R104K	0.24
CESC	chr15	22883006	Silent	rs752649591	L894L	0.23
CESC	chr15	22875265	Missense_Mutation	rs772883059	E1017K	0.29
CESC	chr15	22944629	Missense_Mutation	novel	E106Q	0.38
CESC	chr15	22882945	Nonsense_Mutation	novel	Q915*	0.31
CESC	chr15	22874599	Missense_Mutation	novel	Y1054F	0.44
COAD	chr15	22918852	Missense_Mutation	rs759931816	A456T	0.13
COAD	chr15	22916724	Intron	rs181928454		0.37
COAD	chr15	22916901	Intron	novel		0.11
COAD	chr15	22874634	Silent	novel	R1042R	0.36
COAD	chr15	22926048	Silent	rs779224600	S431S	0.23
COAD	chr15	22917909	Missense_Mutation	novel	V518A	0.3
COAD	chr15	22928021	Missense_Mutation	novel	T373M	0.57
COAD	chr15	22927987	Silent	novel	D384D	0.11
COAD	chr15	22873612	Missense_Mutation	novel	R1110C	0.28
COAD	chr15	22879916	Silent	novel	S1013S	0.34
COAD	chr15	22918796	Silent	rs768369679	H474H	0.25
COAD	chr15	22873622	Missense_Mutation	novel	D1106E	0.12
COAD	chr15	22944582	Frame_Shift_Del	novel	*K121Nfs2**	0.14
COAD	chr15	22918758	Missense_Mutation	novel	F487C	0.5
COAD	chr15	22939302	Missense_Mutation	rs778270959	E229K	0.09
COAD	chr15	22939220	Missense_Mutation	rs750340297	T256M	0.23
COAD	chr15	22874614	Missense_Mutation	novel	R1049I	0.3
COAD	chr15	22917833	Silent	rs761659015	F543F	0.35
COAD	chr15	22882909	Missense_Mutation	rs763053554	A927T	0.1
COAD	chr15	22912183	Missense_Mutation	novel	A693V	0.5
COAD	chr15	22916856	Intron	rs530831446		0.24
COAD	chr15	22916838	Intron	rs564924311		0.29
COAD	chr15	22939239	Missense_Mutation	novel	E250K	0.13
COAD	chr15	22943181	Silent	rs530221441	A187A	0.17
ESCA	chr15	22916937	Intron	novel		0.1
ESCA	chr15	22873608	Missense_Mutation	novel	G1111E	0.32
ESCA	chr15	22926072	Silent	novel	Y423Y	0.35
GBM	chr15	22947077	Missense_Mutation	novel	N45H	0.05
GBM	chr15	22882979	Silent	novel	G903G	0.09
GBM	chr15	22917817	Missense_Mutation	novel	R549C	0.54
GBM	chr15	22927971	Missense_Mutation	novel	L390F	0.31
GBM	chr15	22914879	Missense_Mutation	novel	T611M	0.25
GBM	chr15	22918729	Missense_Mutation	rs371096368	R497W	0.58
GBM	chr15	22918821	Missense_Mutation	novel	G466A	0.38
GBM	chr15	22870135	Missense_Mutation	novel	I1219F	0.11
GBM	chr15	22916675	Intron	novel		0.17
GBM	chr15	22943179	Missense_Mutation	novel	Y188C	0.53
HNSC	chr15	22870009	3'UTR	rs747295890		0.14
HNSC	chr15	22875262	Missense_Mutation	novel	E1018Q	0.36
HNSC	chr15	22937151	Missense_Mutation	novel	D285N	0.17
HNSC	chr15	22870075	Missense_Mutation	novel	V1239M	0.17
HNSC	chr15	22943227	Missense_Mutation	novel	D172G	0.08
HNSC	chr15	22916574	Missense_Mutation	novel	K577N	0.67
HNSC	chr15	22943199	Silent	novel	V181V	0.16
HNSC	chr15	22937172	Missense_Mutation	novel	V278I	0.14
HNSC	chr15	22947264	Missense_Mutation	novel	E8K	0.16
HNSC	chr15	22882927	Missense_Mutation	novel	L921F	0.45
HNSC	chr15	22926024	Silent	rs765112283	T439T	0.13
HNSC	chr15	22947042	Silent	rs745649616	I56I	0.26
HNSC	chr15	22875213	Missense_Mutation	novel	R1034Q	0.45
HNSC	chr15	22916696	Intron	novel		0.4
HNSC	chr15	22939285	Silent	rs180812136	Y234Y	0.25
HNSC	chr15	22873619	Silent	novel	P1107P	0.22
KICH	chr15	22873612	Missense_Mutation	novel	R1110C	0.25
KIRC	chr15	22917935	Splice_Region	novel	S509S	0.09
KIRP	chr15	22881905	Missense_Mutation	novel	T951M	0.54
KIRP	chr15	22943194	Frame_Shift_Del	novel	*N183Tfs48**	0.19
LAML	chr15	22939476	Missense_Mutation	novel	P201S	0.6
LGG	chr15	22914860	Silent	novel	D617D	0.39
LGG	chr15	22932310	Silent	novel	P341P	0.38
LIHC	chr15	22870035	Missense_Mutation	novel	S1252N	0.44
LIHC	chr15	22917071	Intron	novel		0.27
LIHC	chr15	22912217	Missense_Mutation	novel	F682I	0.36
LIHC	chr15	22932236	Missense_Mutation	novel	Y366C	0.29
LUAD	chr15	22903722	Missense_Mutation	novel	N858Y	0.29
LUAD	chr15	22914806	Silent	novel	R635R	0.12
LUAD	chr15	22917843	Missense_Mutation	novel	K540R	0.4
LUAD	chr15	22872961	Missense_Mutation	novel	G1154A	0.23
LUAD	chr15	22939492	Silent	novel	L195L	0.36
LUAD	chr15	22927957	Silent	novel	A394A	0.32
LUAD	chr15	22914779	Missense_Mutation	novel	M644I	0.42
LUAD	chr15	22933802	Missense_Mutation	novel	R331L	0.16
LUAD	chr15	22933884	Missense_Mutation	novel	V304L	0.35
LUAD	chr15	22909268	Missense_Mutation	novel	V772F	0.58
LUAD	chr15	22939411	Missense_Mutation	novel	Q222H	0.53
LUAD	chr15	22912196	Missense_Mutation	novel	D689Y	0.37
LUAD	chr15	22910588	Missense_Mutation	novel	Q734K	0.25
LUAD	chr15	22947294	Splice_Region	novel		0.24
LUAD	chr15	22947279	Frame_Shift_Del	novel	*A3Pfs3**	0.26
LUAD	chr15	22937159	Missense_Mutation	rs376633086	Y282C	0.13
LUSC	chr15	22933878	Missense_Mutation	novel	P306A	0.07
LUSC	chr15	22879960	Missense_Mutation	novel	E999K	0.19
LUSC	chr15	22903812	Missense_Mutation	novel	A828S	0.14
LUSC	chr15	22910572	Missense_Mutation	novel	H739L	0.47
LUSC	chr15	22873658	Missense_Mutation	novel	E1094D	0.08
LUSC	chr15	22916661	Intron	novel		0.2
LUSC	chr15	22917912	Missense_Mutation	novel	T517I	0.34
LUSC	chr15	22909303	Missense_Mutation	novel	R760T	0.44
LUSC	chr15	22916640	Intron	novel		0.35
LUSC	chr15	22925984	Missense_Mutation	novel	E453Q	0.37
LUSC	chr15	22912229	Missense_Mutation	rs541693635	A678T	0.32
LUSC	chr15	22910798	Missense_Mutation	novel	D700H	0.11
LUSC	chr15	22903899	Missense_Mutation	novel	D799N	0.13
LUSC	chr15	22909226	Nonsense_Mutation	novel	R786*	0.05
LUSC	chr15	22932241	Silent	novel	A364A	0.47
LUSC	chr15	22910531	Missense_Mutation	novel	R753W	0.14
OV	chr15	22903822	Missense_Mutation	novel	M824I	0.25
OV	chr15	22874572	Missense_Mutation	novel	I1063S	0.08
OV	chr15	22917872	Silent	novel	D530D	0.33
OV	chr15	22943296	Missense_Mutation	novel	R149K	0.26
OV	chr15	22873632	Missense_Mutation	novel	F1103S	0.17
OV	chr15	22873644	Missense_Mutation	novel	R1099L	0.66
OV	chr15	22874587	Missense_Mutation	novel	H1058R	0.13
OV	chr15	22932276	Missense_Mutation	rs369156833	R353C	0.42
OV	chr15	22910598	Missense_Mutation	novel	E730D	0.09
OV	chr15	22873719	Missense_Mutation	novel	I1074S	0.06
OV	chr15	22914773	Nonsense_Mutation	novel	W646*	0.38
PRAD	chr15	22927957	Silent	novel	A394A	0.41
PRAD	chr15	22943203	Missense_Mutation	novel	S180I	0.27
PRAD	chr15	22943212	Missense_Mutation	rs750888124	M177T	0.13
PRAD	chr15	22882871	Silent	novel	S939S	0.16
PRAD	chr15	22882964	Silent	rs145238748	F908F	0.46
PRAD	chr15	22937193	Missense_Mutation	novel	L271M	0.11
READ	chr15	22870165	Missense_Mutation	rs371607573	R1209C	0.35
READ	chr15	22943338	Missense_Mutation	rs746030413	R135H	0.27
READ	chr15	22909220	Missense_Mutation	novel	E788K	0.32
SARC	chr15	22933849	Silent	novel	L315L	0.07
SKCM	chr15	22932256	Silent	novel	F359F	0.37
SKCM	chr15	22939468	Silent	novel	S203S	0.16
SKCM	chr15	22917920	Silent	novel	I514I	0.39
SKCM	chr15	22882880	Silent	rs148724829	V936V	0.4
SKCM	chr15	22918813	Missense_Mutation	novel	E469K	0.11
SKCM	chr15	22927999	Silent	novel	A380A	0.4
SKCM	chr15	22879924	Missense_Mutation	rs764318239	E1011K	0.54
SKCM	chr15	22916645	Intron	novel		0.35
SKCM	chr15	22910563	Missense_Mutation	rs139576657	P742L	0.45
SKCM	chr15	22939237	Silent	novel	E250E	0.31
SKCM	chr15	22892970	Missense_Mutation	novel	R866W	0.46
SKCM	chr15	22943325	Silent	rs749388185	E139E	0.37
SKCM	chr15	22944561	Silent	rs377250174	F128F	0.2
SKCM	chr15	22909246	Missense_Mutation	novel	S779F	0.35
SKCM	chr15	22939418	Missense_Mutation	novel	I220T	0.09
SKCM	chr15	22903741	Silent	novel	F851F	0.16
SKCM	chr15	22937193	Splice_Site	novel	X266_splice	0.06
SKCM	chr15	22903783	Silent	novel	G837G	0.22
SKCM	chr15	22903784	Missense_Mutation	novel	G837E	0.23
SKCM	chr15	22912202	Silent	novel	L687L	0.33
SKCM	chr15	22903825	Silent	novel	A823A	0.26
SKCM	chr15	22873616	Silent	novel	I1108I	0.36
SKCM	chr15	22927961	Missense_Mutation	novel	L393Q	0.48
SKCM	chr15	22927928	Nonsense_Mutation	novel	W404*	0.21
SKCM	chr15	22910794	Missense_Mutation	novel	Q701R	0.41
STAD	chr15	22917812	Silent	rs559730613	R550R	0.29
STAD	chr15	22872926	Missense_Mutation	rs182057951	V1166I	0.34
STAD	chr15	22944903	Missense_Mutation	novel	M82V	0.26
STAD	chr15	22873677	Missense_Mutation	novel	C1088Y	0.28
STAD	chr15	22875214	Nonsense_Mutation	novel	R1034*	0.22
STAD	chr15	22870103	Silent	rs369837466	G1229G	0.34
STAD	chr15	22943299	Missense_Mutation	novel	R148M	0.3
STAD	chr15	22869958	3'UTR	novel		0.54
STAD	chr15	22918728	Missense_Mutation	novel	R497Q	0.35
STAD	chr15	22872905	Missense_Mutation	rs374943727	R1173C	0.21
STAD	chr15	22916522	Missense_Mutation	novel	F595I	0.08
STAD	chr15	22932304	Nonsense_Mutation	novel	Y343*	0.16
STAD	chr15	22916785	Intron	rs377212782		0.29
STAD	chr15	22918851	Missense_Mutation	novel	A456V	0.14
STAD	chr15	22944604	Missense_Mutation	novel	V114A	0.25
STAD	chr15	22873677	Missense_Mutation	novel	C1088Y	0.25
STAD	chr15	22870132	Missense_Mutation	rs771581093	T1220P	0.27
STAD	chr15	22926024	Silent	rs765112283	T439T	0.49
STAD	chr15	22947042	Silent	rs745649616	I56I	0.25
STAD	chr15	22918770	Missense_Mutation	novel	A483G	0.21
STAD	chr15	22916586	Silent	novel	K573K	0.05
STAD	chr15	22903759	Missense_Mutation	novel	W845C	0.13
STAD	chr15	22916676	Intron	novel		0.19
STAD	chr15	22917839	Silent	rs764174349	S541S	0.09
STAD	chr15	22873717	Missense_Mutation	novel	A1075T	0.28
STAD	chr15	22875242	Silent	rs762296538	H1024H	0.07
STAD	chr15	22927921	Silent	novel	A406A	0.39
THCA	chr15	22916687	Intron	novel		0.19
UCEC	chr15	22870021	3'UTR	rs199636573		0.41
UCEC	chr15	22869979	3'UTR	novel		0.16
UCEC	chr15	22903751	Missense_Mutation	novel	N848S	0.44
UCEC	chr15	22916561	Missense_Mutation	novel	S582R	0.12
UCEC	chr15	22933801	Splice_Site	novel	X331_splice	0.38
UCEC	chr15	22869980	3'UTR	rs201977921		0.25
UCEC	chr15	22870165	Missense_Mutation	rs371607573	R1209C	0.4
UCEC	chr15	22910542	Missense_Mutation	novel	L749P	0.5
UCEC	chr15	22916807	Intron	novel		0.15
UCEC	chr15	22918853	Silent	rs772849852	I455I	0.4
UCEC	chr15	22939280	Missense_Mutation	novel	E236G	0.47
UCEC	chr15	22943303	Missense_Mutation	novel	E147K	0.27
UCEC	chr15	22881929	Missense_Mutation	novel	G943D	0.12
UCEC	chr15	22873684	Missense_Mutation	novel	L1086I	0.11
UCEC	chr15	22947017	Missense_Mutation	rs751438013	V65I	0.41
UCEC	chr15	22916494	Missense_Mutation	novel	H604R	0.14
UCEC	chr15	22916750	Intron	rs762679316		0.38
UCEC	chr15	22933827	Missense_Mutation	rs778294512	A323T	0.34
UCEC	chr15	22928014	Silent	novel	S375S	0.36
UCEC	chr15	22933819	Silent	rs781319942	Y325Y	0.06
UCEC	chr15	22932251	Missense_Mutation	novel	S361L	0.39
UCEC	chr15	22872827	Missense_Mutation	novel	V1199M	0.39
UCEC	chr15	22937181	Missense_Mutation	novel	D275N	0.4
UCEC	chr15	22926005	Missense_Mutation	rs767686408	E446K	0.22
UCEC	chr15	22873593	Missense_Mutation	novel	N1116S	0.56
UCEC	chr15	22872951	Silent	novel	L1157L	0.04
UCEC	chr15	22909234	Missense_Mutation	rs746357125	A783V	0.08
UCEC	chr15	22918722	Missense_Mutation	novel	A499V	0.26
UCEC	chr15	22944883	Silent	rs367831397	S88S	0.08
UCEC	chr15	22932239	Missense_Mutation	rs771703298	R365H	0.22
UCEC	chr15	22869975	3'UTR	novel		0.1
UCEC	chr15	22909234	Missense_Mutation	rs746357125	A783V	0.2
UCEC	chr15	22910550	Silent	rs141106211	Y746Y	0.39
UCEC	chr15	22917005	Intron	novel		0.23
UCEC	chr15	22870165	Missense_Mutation	rs371607573	R1209C	0.18
UCEC	chr15	22881870	Missense_Mutation	novel	P963T	0.25
UCEC	chr15	22917911	Silent	rs751438422	T517T	0.18
UCEC	chr15	22937119	Silent	novel	I295I	0.44
UCEC	chr15	22870165	Missense_Mutation	rs371607573	R1209C	0.45
UCEC	chr15	22873574	Silent	rs140215868	D1122D	0.46
UCEC	chr15	22916829	Intron	rs532499747		0.15
UCEC	chr15	22918852	Missense_Mutation	rs759931816	A456T	0.19
UCEC	chr15	22870103	Silent	rs369837466	G1229G	0.33
UCEC	chr15	22873612	Missense_Mutation	novel	R1110C	0.61
UCEC	chr15	22881877	Silent	novel	C960C	0.35
UCEC	chr15	22883011	Missense_Mutation	novel	A893T	0.42
UCEC	chr15	22939491	Missense_Mutation	rs759738036	R196C	0.27
UCEC	chr15	22947257	Missense_Mutation	rs761297983	A10V	0.47
UCEC	chr15	22903831	Silent	rs754335429	F821F	0.35
UCEC	chr15	22939302	Missense_Mutation	rs778270959	E229K	0.43
UCEC	chr15	22909283	Missense_Mutation	novel	L767M	0.46
UCEC	chr15	22947259	Silent	rs138799074	D9D	0.46
UCEC	chr15	22910592	Missense_Mutation	novel	K732N	0.61
UCEC	chr15	22943286	Silent	novel	F152F	0.54
UCEC	chr15	22873644	Missense_Mutation	novel	R1099Q	0.14
UCEC	chr15	22903986	Intron	novel		0.46
UCEC	chr15	22875240	Missense_Mutation	rs138063523	A1025V	0.19
UCEC	chr15	22909284	Silent	novel	R766R	0.05
UCEC	chr15	22932327	Missense_Mutation	novel	S336P	0.33
UCEC	chr15	22939211	Missense_Mutation	novel	E259G	0.42
UCEC	chr15	22916528	Nonsense_Mutation	novel	E593*	0.12
UCEC	chr15	22870103	Silent	rs369837466	G1229G	0.46
UCEC	chr15	22873672	Missense_Mutation	novel	L1090V	0.38
UCEC	chr15	22916787	Intron	rs373567009		0.16
UCEC	chr15	22939227	Missense_Mutation	novel	Y254H	0.42
UCEC	chr15	22870009	3'UTR	rs747295890		0.5
UCEC	chr15	22882964	Silent	rs145238748	F908F	0.48
UCEC	chr15	22916516	Nonsense_Mutation	novel	R597*	0.32
UCEC	chr15	22916738	Intron	rs374541910		0.16
UCEC	chr15	22917832	Missense_Mutation	rs767421257	D544N	0.45
UCEC	chr15	22932270	Missense_Mutation	novel	D355N	0.41
UCEC	chr15	22939303	Silent	rs12441795	L228L	0.34
UCEC	chr15	22881913	Silent	rs142271563	Y948Y	0.46
UCEC	chr15	22916861	Intron	novel		0.13
UCEC	chr15	22869910	3'UTR	novel		0.18
UCEC	chr15	22879981	Missense_Mutation	rs769678421	V992L	0.43
UCEC	chr15	22910544	Silent	rs372060948	T748T	0.19
UCEC	chr15	22917043	Intron	novel		0.18
UCEC	chr15	22917815	Silent	novel	R549R	0.19
UCEC	chr15	22910611	Missense_Mutation	novel	R726Q	0.45
UCEC	chr15	22882904	Silent	novel	V928V	0.42
UCEC	chr15	22916656	Intron	novel		0.35
UCEC	chr15	22947205	Silent	novel	P27P	0.36
UCEC	chr15	22914854	Silent	rs147012760	S619S	0.24
UCEC	chr15	22916516	Nonsense_Mutation	novel	R597*	0.39
UCEC	chr15	22937130	Missense_Mutation	novel	L292V	0.45
UCEC	chr15	22943286	Silent	novel	F152F	0.59
UCEC	chr15	22917061	Intron	novel		0.38
UCEC	chr15	22875270	Missense_Mutation	novel	S1015Y	0.13
UCEC	chr15	22872908	Missense_Mutation	rs765442644	R1172W	0.19
UCEC	chr15	22873687	Missense_Mutation	novel	R1085C	0.23
UCEC	chr15	22914740	Missense_Mutation	novel	E657D	0.23
UCEC	chr15	22937119	Silent	novel	I295I	0.17
UCEC	chr15	22873574	Silent	rs140215868	D1122D	0.2
UCEC	chr15	22926006	Silent	rs149205451	S445S	0.25
UCEC	chr15	22870010	3'UTR	rs370764190		0.36
UCEC	chr15	22912177	Splice_Site	novel	X694_splice	0.41
UCEC	chr15	22916640	Intron	novel		0.31
UCEC	chr15	22947198	Missense_Mutation	novel	E30K	0.41
UCS	chr15	22939302	Missense_Mutation	rs778270959	E229K	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2111	0.079424
COAD	DEL	0.3592	1.0065e-06
ESCA	DEL	0.2228	0.035837
HNSC	DEL	0.1475	0.11567
KICH	AMP	0.2576	0.21756
KIRP	DEL	0.1076	0.2062
LUAD	DEL	0.3702	4.137e-10
LUSC	DEL	0.2236	5.9764e-05
PAAD	DEL	0.1033	0.13216
PRAD	AMP	0.0224	0.015423
READ	DEL	0.4	0.025797
SARC	DEL	0.144	0.18974
STAD	DEL	0.195	3.7853e-05

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0072	Kaplan-Meier Survival Analysis
KIRC	0.00011	Kaplan-Meier Survival Analysis
ACC	0.0025	Kaplan-Meier Survival Analysis
LUSC	0.05	Kaplan-Meier Survival Analysis
KIRP	0.0069	Kaplan-Meier Survival Analysis
PAAD	0.0038	Kaplan-Meier Survival Analysis
BLCA	0.0039	Kaplan-Meier Survival Analysis
UCEC	0.0063	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.037	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000273749 (Gene tree)
Gene ID: 23191
Gene Symbol: CYFIP1
Alias: KIAA0068|P140SRA-1|SHYC
Full Name: cytoplasmic FMR1 interacting protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 114,012 bases
Position: chr15:22,867,052-22,981,063
Accession: 13759
RBP type: non-canonical RBP
Summary: This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, May 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18805096	The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.	Cell	2008 Sep 19	Napoli I	doi: 10.1016/j.cell.2008.07.031.
30982501	Neuronal function and dysfunction of CYFIP2: from actin dynamics to early infantile epileptic encephalopathy.	BMB Rep	2019 May	Zhang Y	-

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000612288	CYFIP1-205	553	-	ENSP00000479802	185 (aa)	-	A0A087WVZ5
ENST00000611832	CYFIP1-204	582	-	ENSP00000478377	151 (aa)	-	A0A087WU52
ENST00000621036	CYFIP1-212	585	-	-	- (aa)	-	-
ENST00000619037	CYFIP1-209	575	-	ENSP00000480596	77 (aa)	-	A0A087WWY5
ENST00000561263	CYFIP1-202	707	-	ENSP00000453060	176 (aa)	-	H0YL50
ENST00000622576	CYFIP1-214	583	-	ENSP00000482459	45 (aa)	-	A0A087WZ89
ENST00000621105	CYFIP1-213	514	-	-	- (aa)	-	-
ENST00000617928	CYFIP1-208	6793	XM_011543873	ENSP00000481038	1253 (aa)	XP_011542175	Q7L576
ENST00000613006	CYFIP1-206	544	-	ENSP00000480307	161 (aa)	-	A0A087WWL1
ENST00000610365	CYFIP1-203	4515	XM_017022024	ENSP00000478779	1253 (aa)	XP_016877513	Q7L576
ENST00000617556	CYFIP1-207	5674	-	ENSP00000480525	822 (aa)	-	Q7L576
ENST00000619348	CYFIP1-211	3471	-	-	- (aa)	-	-
ENST00000557890	CYFIP1-201	408	-	-	- (aa)	-	-
ENST00000619290	CYFIP1-210	929	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000273749's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000273749	E-Selectin	4.8903000E-005	19729612
ENSG00000273749	Muscle, Skeletal	8.2200000E-005	-
ENSG00000273749	Muscle, Skeletal	1.8540000E-005	-
ENSG00000273749	Rotator Cuff	9.9240000E-005	-
ENSG00000273749	Muscle, Skeletal	9.1970000E-005	-
ENSG00000273749	Muscle, Skeletal	4.6700000E-005	-
ENSG00000273749	Waist Circumference	6.8980000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000273749	rs7170637	15	22903836	?	Heel bone mineral density	30048462	[0.012-0.023] unit increase	0.0172789	EFO_0009270
ENSG00000273749	rs7170637	15	22903836	G	Heel bone mineral density	30598549	[0.013-0.023] unit increase	0.0180226	EFO_0009270
ENSG00000273749	rs11636046	15	22949326	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000273749	rs7170637	15	22903836	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000273749's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000273749	CYFIP1	100	92.053	ENSG00000055163	CYFIP2	100	93.694	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000340	RNA 7-methylguanosine cap binding	21873635.	IBA	Function
GO:0000902	cell morphogenesis	21873635.	IBA	Process
GO:0001726	ruffle	-	ISS	Component
GO:0005515	protein binding	11438699.15294869.15296760.16260607.18805096.19363480.21107423.24439377.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005845	mRNA cap binding complex	-	ISS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006417	regulation of translation	21873635.	IBA	Process
GO:0007411	axon guidance	21873635.	IBA	Process
GO:0008360	regulation of cell shape	-	IEA	Process
GO:0016601	Rac protein signal transduction	21107423.	IMP	Process
GO:0030027	lamellipodium	-	ISS	Component
GO:0030031	cell projection assembly	21873635.	IBA	Process
GO:0030032	lamellipodium assembly	21873635.	IBA	Process
GO:0030032	lamellipodium assembly	-	ISS	Process
GO:0031209	SCAR complex	21873635.	IBA	Component
GO:0031209	SCAR complex	21107423.	IMP	Component
GO:0031529	ruffle organization	-	ISS	Process
GO:0032433	filopodium tip	-	IEA	Component
GO:0032869	cellular response to insulin stimulus	-	IEA	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0035580	specific granule lumen	-	TAS	Component
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	Process
GO:0043005	neuron projection	21873635.	IBA	Component
GO:0043005	neuron projection	-	ISS	Component
GO:0043025	neuronal cell body	-	IEA	Component
GO:0043195	terminal bouton	-	IEA	Component
GO:0043197	dendritic spine	-	IEA	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0044294	dendritic growth cone	-	IEA	Component
GO:0044295	axonal growth cone	-	IEA	Component
GO:0045182	translation regulator activity	-	IEA	Function
GO:0045202	synapse	21873635.	IBA	Component
GO:0045773	positive regulation of axon extension	-	IEA	Process
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	Process
GO:0048365	Rac GTPase binding	21107423.	IMP	Function
GO:0048365	Rac GTPase binding	-	ISS	Function
GO:0048471	perinuclear region of cytoplasm	-	ISS	Component
GO:0048675	axon extension	16260607.	IMP	Process
GO:0050890	cognition	17519220.	IMP	Process
GO:0051015	actin filament binding	-	ISS	Function
GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway	-	IEA	Process
GO:0051602	response to electrical stimulus	-	IEA	Process
GO:0060076	excitatory synapse	-	IEA	Component
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component
GO:0090724	central region of growth cone	-	IEA	Component
GO:0090725	peripheral region of growth cone	-	IEA	Component
GO:0097484	dendrite extension	-	IEA	Process
GO:0099563	modification of synaptic structure	21873635.	IBA	Process
GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	-	IEA	Process
GO:1900006	positive regulation of dendrite development	-	IEA	Process
GO:1900029	positive regulation of ruffle assembly	-	IEA	Process
GO:1903422	negative regulation of synaptic vesicle recycling	-	IEA	Process
GO:1904724	tertiary granule lumen	-	TAS	Component
GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	-	IEA	Process
GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	21107423.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.